Stem definition | Drug id | CAS RN |
---|---|---|
1112 | 33419-42-0 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.22 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 38 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 6.30 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 52 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.18 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.12 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5.70 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 10, 1983 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 2147.52 | 15.50 | 1239 | 41945 | 93388 | 46549490 |
Neutropenia | 915.84 | 15.50 | 875 | 42309 | 142329 | 46500549 |
Bone marrow failure | 727.80 | 15.50 | 410 | 42774 | 29259 | 46613619 |
Mucosal inflammation | 696.23 | 15.50 | 439 | 42745 | 38537 | 46604341 |
Pancytopenia | 610.57 | 15.50 | 555 | 42629 | 84503 | 46558375 |
Acute myeloid leukaemia | 607.38 | 15.50 | 295 | 42889 | 15483 | 46627395 |
Product use in unapproved indication | 516.78 | 15.50 | 520 | 42664 | 89753 | 46553125 |
Haemophagocytic lymphohistiocytosis | 478.79 | 15.50 | 206 | 42978 | 8136 | 46634742 |
Myelodysplastic syndrome | 470.75 | 15.50 | 248 | 42936 | 15463 | 46627415 |
Thrombocytopenia | 462.83 | 15.50 | 577 | 42607 | 126004 | 46516874 |
Haematotoxicity | 403.77 | 15.50 | 173 | 43011 | 6760 | 46636118 |
Ovarian failure | 398.52 | 15.50 | 109 | 43075 | 1023 | 46641855 |
Off label use | 332.52 | 15.50 | 932 | 42252 | 378909 | 46263969 |
Sepsis | 307.69 | 15.50 | 493 | 42691 | 135521 | 46507357 |
Febrile bone marrow aplasia | 278.16 | 15.50 | 133 | 43051 | 6729 | 46636149 |
Second primary malignancy | 271.12 | 15.50 | 129 | 43055 | 6455 | 46636423 |
Disease progression | 264.98 | 15.50 | 372 | 42812 | 90928 | 46551950 |
Tumour lysis syndrome | 239.01 | 15.50 | 122 | 43062 | 7114 | 46635764 |
Multiple organ dysfunction syndrome | 228.54 | 15.50 | 260 | 42924 | 51450 | 46591428 |
Posterior reversible encephalopathy syndrome | 227.05 | 15.50 | 153 | 43031 | 14988 | 46627890 |
Venoocclusive liver disease | 221.18 | 15.50 | 98 | 43086 | 4153 | 46638725 |
Malignant neoplasm progression | 216.33 | 15.50 | 283 | 42901 | 64643 | 46578235 |
Maternal exposure before pregnancy | 203.65 | 15.50 | 94 | 43090 | 4387 | 46638491 |
Septic shock | 201.70 | 15.50 | 258 | 42926 | 57635 | 46585243 |
Neutropenic sepsis | 188.29 | 15.50 | 126 | 43058 | 12198 | 46630680 |
Diffuse large B-cell lymphoma refractory | 185.08 | 15.50 | 58 | 43126 | 906 | 46641972 |
Pain | 183.90 | 15.50 | 107 | 43077 | 476841 | 46166037 |
Arthralgia | 181.63 | 15.50 | 56 | 43128 | 364547 | 46278331 |
Aplasia | 181.43 | 15.50 | 81 | 43103 | 3495 | 46639383 |
Teratoma | 175.08 | 15.50 | 39 | 43145 | 136 | 46642742 |
Encephalopathy | 169.30 | 15.50 | 181 | 43003 | 33408 | 46609470 |
Myelosuppression | 168.74 | 15.50 | 99 | 43085 | 7604 | 46635274 |
Ovarian germ cell teratoma | 168.60 | 15.50 | 35 | 43149 | 78 | 46642800 |
Stem cell transplant | 165.13 | 15.50 | 62 | 43122 | 1704 | 46641174 |
Fall | 164.85 | 15.50 | 50 | 43134 | 329047 | 46313831 |
Pyrexia | 163.37 | 15.50 | 696 | 42488 | 348106 | 46294772 |
Drug hypersensitivity | 148.24 | 15.50 | 24 | 43160 | 243801 | 46399077 |
Hepatosplenic T-cell lymphoma | 142.69 | 15.50 | 43 | 43141 | 585 | 46642293 |
Venoocclusive disease | 141.50 | 15.50 | 57 | 43127 | 1899 | 46640979 |
Neutrophil count decreased | 141.03 | 15.50 | 187 | 42997 | 43239 | 46599639 |
Cytomegalovirus infection | 136.92 | 15.50 | 122 | 43062 | 18022 | 46624856 |
Joint swelling | 135.28 | 15.50 | 4 | 43180 | 166069 | 46476809 |
Diffuse large B-cell lymphoma recurrent | 130.90 | 15.50 | 50 | 43134 | 1442 | 46641436 |
Leukopenia | 129.30 | 15.50 | 229 | 42955 | 68114 | 46574764 |
Headache | 121.68 | 15.50 | 159 | 43025 | 478193 | 46164685 |
Disease recurrence | 121.47 | 15.50 | 115 | 43069 | 18356 | 46624522 |
Drug resistance | 119.72 | 15.50 | 111 | 43073 | 17257 | 46625621 |
Platelet count decreased | 115.30 | 15.50 | 273 | 42911 | 99751 | 46543127 |
Neutropenic colitis | 114.64 | 15.50 | 51 | 43133 | 2181 | 46640697 |
Nasopharyngitis | 114.57 | 15.50 | 7 | 43177 | 153991 | 46488887 |
Product dose omission issue | 113.35 | 15.50 | 12 | 43172 | 168508 | 46474370 |
Cardiotoxicity | 113.07 | 15.50 | 73 | 43111 | 6649 | 46636229 |
Aspergillus infection | 111.43 | 15.50 | 73 | 43111 | 6817 | 46636061 |
Bacteraemia | 110.29 | 15.50 | 97 | 43087 | 14082 | 46628796 |
Peripheral swelling | 109.60 | 15.50 | 10 | 43174 | 158061 | 46484817 |
Ototoxicity | 109.01 | 15.50 | 40 | 43144 | 1029 | 46641849 |
Diffuse large B-cell lymphoma | 98.68 | 15.50 | 64 | 43120 | 5874 | 46637004 |
Pain in extremity | 98.05 | 15.50 | 59 | 43125 | 258621 | 46384257 |
Fatigue | 97.10 | 15.50 | 268 | 42916 | 608429 | 46034449 |
Malignant transformation | 95.58 | 15.50 | 27 | 43157 | 288 | 46642590 |
Acute graft versus host disease | 94.11 | 15.50 | 54 | 43130 | 3976 | 46638902 |
Premature menopause | 92.98 | 15.50 | 32 | 43152 | 679 | 46642199 |
Dizziness | 92.89 | 15.50 | 107 | 43077 | 340307 | 46302571 |
Pruritus | 92.23 | 15.50 | 55 | 43129 | 242297 | 46400581 |
Insomnia | 92.12 | 15.50 | 20 | 43164 | 164904 | 46477974 |
Oesophagitis | 91.68 | 15.50 | 86 | 43098 | 13565 | 46629313 |
Alveolar soft part sarcoma | 91.61 | 15.50 | 21 | 43163 | 86 | 46642792 |
Osteosarcoma | 89.60 | 15.50 | 22 | 43162 | 128 | 46642750 |
Malaise | 89.42 | 15.50 | 105 | 43079 | 331127 | 46311751 |
Graft versus host disease | 87.96 | 15.50 | 62 | 43122 | 6526 | 46636352 |
Neoplasm progression | 86.75 | 15.50 | 115 | 43069 | 26568 | 46616310 |
Pulmonary haemorrhage | 86.35 | 15.50 | 61 | 43123 | 6444 | 46636434 |
Primary hypogonadism | 86.23 | 15.50 | 22 | 43162 | 153 | 46642725 |
Neurotoxicity | 85.63 | 15.50 | 83 | 43101 | 13634 | 46629244 |
Enterococcal infection | 82.43 | 15.50 | 61 | 43123 | 6926 | 46635952 |
Anaemia | 82.35 | 15.50 | 459 | 42725 | 255320 | 46387558 |
Anxiety | 81.75 | 15.50 | 33 | 43151 | 181924 | 46460954 |
Cystitis haemorrhagic | 81.42 | 15.50 | 47 | 43137 | 3500 | 46639378 |
Abdominal discomfort | 81.10 | 15.50 | 20 | 43164 | 151145 | 46491733 |
Weight increased | 78.64 | 15.50 | 27 | 43157 | 164446 | 46478432 |
Acute lymphocytic leukaemia | 78.00 | 15.50 | 42 | 43142 | 2731 | 46640147 |
Nephroblastoma | 77.91 | 15.50 | 19 | 43165 | 107 | 46642771 |
Acute lymphocytic leukaemia recurrent | 77.04 | 15.50 | 38 | 43146 | 2057 | 46640821 |
Injection site pain | 76.39 | 15.50 | 6 | 43178 | 107146 | 46535732 |
Nephropathy toxic | 74.59 | 15.50 | 59 | 43125 | 7395 | 46635483 |
Human herpesvirus 6 infection | 74.42 | 15.50 | 39 | 43145 | 2400 | 46640478 |
Bronchopulmonary aspergillosis | 74.29 | 15.50 | 59 | 43125 | 7437 | 46635441 |
Musculoskeletal stiffness | 74.25 | 15.50 | 4 | 43180 | 97989 | 46544889 |
Colitis | 72.99 | 15.50 | 127 | 43057 | 37220 | 46605658 |
Teratoma benign | 72.45 | 15.50 | 16 | 43168 | 53 | 46642825 |
Complications of bone marrow transplant | 69.25 | 15.50 | 23 | 43161 | 436 | 46642442 |
Cytomegalovirus viraemia | 68.91 | 15.50 | 46 | 43138 | 4432 | 46638446 |
Asthma | 68.54 | 15.50 | 4 | 43180 | 91538 | 46551340 |
Cytopenia | 68.26 | 15.50 | 57 | 43127 | 7711 | 46635167 |
Retinoblastoma | 66.91 | 15.50 | 17 | 43167 | 116 | 46642762 |
Rash | 66.03 | 15.50 | 145 | 43039 | 356367 | 46286511 |
Urticaria | 64.40 | 15.50 | 15 | 43169 | 117877 | 46525001 |
Fungaemia | 64.09 | 15.50 | 33 | 43151 | 1958 | 46640920 |
Leukoencephalopathy | 63.71 | 15.50 | 42 | 43142 | 3962 | 46638916 |
Gene mutation | 63.02 | 15.50 | 27 | 43157 | 1053 | 46641825 |
Enterobacter infection | 62.84 | 15.50 | 32 | 43152 | 1855 | 46641023 |
Muscle spasms | 62.78 | 15.50 | 18 | 43166 | 123095 | 46519783 |
Capillary leak syndrome | 62.68 | 15.50 | 32 | 43152 | 1865 | 46641013 |
White blood cell count decreased | 61.01 | 15.50 | 235 | 42949 | 111996 | 46530882 |
Thrombotic microangiopathy | 60.97 | 15.50 | 55 | 43129 | 8251 | 46634627 |
Clostridium difficile colitis | 60.36 | 15.50 | 80 | 43104 | 18473 | 46624405 |
Acute promyelocytic leukaemia | 60.34 | 15.50 | 25 | 43159 | 896 | 46641982 |
Epstein-Barr virus infection | 60.07 | 15.50 | 50 | 43134 | 6734 | 46636144 |
Choriocarcinoma | 59.21 | 15.50 | 15 | 43169 | 101 | 46642777 |
Feeling abnormal | 58.95 | 15.50 | 21 | 43163 | 125039 | 46517839 |
Gait disturbance | 58.03 | 15.50 | 31 | 43153 | 145232 | 46497646 |
Lymphopenia | 57.73 | 15.50 | 71 | 43113 | 15222 | 46627656 |
Disseminated intravascular coagulation | 57.34 | 15.50 | 79 | 43105 | 18926 | 46623952 |
Cervix disorder | 56.97 | 15.50 | 20 | 43164 | 451 | 46642427 |
Overdose | 55.64 | 15.50 | 13 | 43171 | 101966 | 46540912 |
BK virus infection | 55.60 | 15.50 | 34 | 43150 | 2815 | 46640063 |
Drug intolerance | 55.00 | 15.50 | 34 | 43150 | 147015 | 46495863 |
Bronchitis | 54.95 | 15.50 | 15 | 43169 | 105964 | 46536914 |
Depression | 54.92 | 15.50 | 46 | 43138 | 170058 | 46472820 |
Human bocavirus infection | 54.91 | 15.50 | 18 | 43166 | 327 | 46642551 |
Candida infection | 54.80 | 15.50 | 84 | 43100 | 22156 | 46620722 |
Large intestinal ulcer perforation | 54.76 | 15.50 | 13 | 43171 | 64 | 46642814 |
Acute myeloid leukaemia recurrent | 53.36 | 15.50 | 26 | 43158 | 1370 | 46641508 |
Arthropathy | 52.15 | 15.50 | 8 | 43176 | 84692 | 46558186 |
JC virus infection | 51.92 | 15.50 | 27 | 43157 | 1635 | 46641243 |
Myeloid leukaemia | 51.60 | 15.50 | 17 | 43167 | 314 | 46642564 |
T-cell lymphoma | 51.33 | 15.50 | 20 | 43164 | 609 | 46642269 |
Graft versus host disease in skin | 50.73 | 15.50 | 30 | 43154 | 2337 | 46640541 |
Neoplasm recurrence | 50.65 | 15.50 | 30 | 43154 | 2343 | 46640535 |
Secondary immunodeficiency | 48.92 | 15.50 | 22 | 43162 | 965 | 46641913 |
Progressive multifocal leukoencephalopathy | 48.29 | 15.50 | 56 | 43128 | 11290 | 46631588 |
Injection site erythema | 48.25 | 15.50 | 6 | 43178 | 74421 | 46568457 |
Deafness | 47.29 | 15.50 | 66 | 43118 | 16002 | 46626876 |
Systemic candida | 46.81 | 15.50 | 30 | 43154 | 2697 | 46640181 |
Hospitalisation | 46.75 | 15.50 | 3 | 43181 | 63382 | 46579496 |
Myalgia | 46.66 | 15.50 | 28 | 43156 | 123060 | 46519818 |
Leukaemia | 46.30 | 15.50 | 32 | 43152 | 3263 | 46639615 |
Post transplant lymphoproliferative disorder | 46.24 | 15.50 | 34 | 43150 | 3822 | 46639056 |
Pleural effusion | 46.13 | 15.50 | 175 | 43009 | 82777 | 46560101 |
Epstein-Barr virus associated lymphoproliferative disorder | 46.13 | 15.50 | 24 | 43160 | 1455 | 46641423 |
Acute respiratory distress syndrome | 46.06 | 15.50 | 77 | 43107 | 21845 | 46621033 |
Abdominal pain upper | 46.03 | 15.50 | 40 | 43144 | 145265 | 46497613 |
Herpes simplex | 45.63 | 15.50 | 44 | 43140 | 7179 | 46635699 |
Klebsiella sepsis | 45.60 | 15.50 | 23 | 43161 | 1306 | 46641572 |
Renal tubular disorder | 44.51 | 15.50 | 28 | 43156 | 2437 | 46640441 |
Acute graft versus host disease in skin | 44.36 | 15.50 | 30 | 43154 | 2952 | 46639926 |
Drug abuse | 43.95 | 15.50 | 4 | 43180 | 63404 | 46579474 |
Encephalitis viral | 43.93 | 15.50 | 24 | 43160 | 1606 | 46641272 |
Arthritis | 43.91 | 15.50 | 9 | 43175 | 77307 | 46565571 |
Blood culture positive | 43.62 | 15.50 | 35 | 43149 | 4477 | 46638401 |
Adenovirus infection | 43.37 | 15.50 | 29 | 43155 | 2801 | 46640077 |
Refractory anaemia with an excess of blasts | 43.33 | 15.50 | 16 | 43168 | 419 | 46642459 |
Varicella zoster virus infection | 43.28 | 15.50 | 27 | 43157 | 2316 | 46640562 |
Amenorrhoea | 43.15 | 15.50 | 47 | 43137 | 8848 | 46634030 |
Leukaemia recurrent | 43.01 | 15.50 | 22 | 43162 | 1287 | 46641591 |
Mesenteric abscess | 42.45 | 15.50 | 11 | 43173 | 82 | 46642796 |
Ascites | 42.24 | 15.50 | 100 | 43084 | 36484 | 46606394 |
Migraine | 42.24 | 15.50 | 7 | 43177 | 70019 | 46572859 |
Superior vena cava syndrome | 42.15 | 15.50 | 17 | 43167 | 568 | 46642310 |
Neuropathy peripheral | 41.97 | 15.50 | 181 | 43003 | 90712 | 46552166 |
Renal salt-wasting syndrome | 41.97 | 15.50 | 13 | 43171 | 195 | 46642683 |
Cutaneous calcification | 41.55 | 15.50 | 11 | 43173 | 90 | 46642788 |
Blood pressure increased | 41.18 | 15.50 | 34 | 43150 | 126632 | 46516246 |
Dyspnoea | 41.07 | 15.50 | 294 | 42890 | 515254 | 46127624 |
Suicidal ideation | 40.61 | 15.50 | 3 | 43181 | 56379 | 46586499 |
Encephalitis cytomegalovirus | 40.50 | 15.50 | 16 | 43168 | 506 | 46642372 |
Hypokalaemia | 40.42 | 15.50 | 175 | 43009 | 87849 | 46555029 |
Hypersensitivity | 40.09 | 15.50 | 48 | 43136 | 150273 | 46492605 |
Hepatitis B reactivation | 40.00 | 15.50 | 22 | 43162 | 1492 | 46641386 |
Memory impairment | 39.98 | 15.50 | 11 | 43173 | 77326 | 46565552 |
Infection | 39.77 | 15.50 | 235 | 42949 | 133357 | 46509521 |
Sweat gland tumour | 39.76 | 15.50 | 11 | 43173 | 108 | 46642770 |
T-cell type acute leukaemia | 39.65 | 15.50 | 10 | 43174 | 66 | 46642812 |
Pneumonia fungal | 39.64 | 15.50 | 32 | 43152 | 4128 | 46638750 |
Stomatitis | 39.56 | 15.50 | 146 | 43038 | 68151 | 46574727 |
Recurrent cancer | 39.55 | 15.50 | 23 | 43161 | 1736 | 46641142 |
Urinary tract infection | 39.55 | 15.50 | 91 | 43093 | 220175 | 46422703 |
Gastrooesophageal reflux disease | 39.53 | 15.50 | 10 | 43174 | 74334 | 46568544 |
Fungal oesophagitis | 39.19 | 15.50 | 16 | 43168 | 552 | 46642326 |
Plasma cell leukaemia | 39.05 | 15.50 | 20 | 43164 | 1173 | 46641705 |
Contusion | 39.04 | 15.50 | 16 | 43168 | 87471 | 46555407 |
Influenza like illness | 38.93 | 15.50 | 4 | 43180 | 57566 | 46585312 |
Listeria sepsis | 38.78 | 15.50 | 16 | 43168 | 567 | 46642311 |
Hyperhidrosis | 38.78 | 15.50 | 17 | 43167 | 89291 | 46553587 |
Respiratory failure | 38.68 | 15.50 | 182 | 43002 | 94634 | 46548244 |
Gastrointestinal fungal infection | 38.63 | 15.50 | 13 | 43171 | 257 | 46642621 |
Nail pigmentation | 38.49 | 15.50 | 12 | 43172 | 184 | 46642694 |
Chloroma | 38.43 | 15.50 | 12 | 43172 | 185 | 46642693 |
Medulloblastoma recurrent | 38.31 | 15.50 | 10 | 43174 | 77 | 46642801 |
Bacterial infection | 38.20 | 15.50 | 60 | 43124 | 16156 | 46626722 |
Swelling | 37.38 | 15.50 | 36 | 43148 | 124475 | 46518403 |
Enterococcal sepsis | 36.86 | 15.50 | 20 | 43164 | 1320 | 46641558 |
Nasal abscess | 36.82 | 15.50 | 11 | 43173 | 145 | 46642733 |
Back pain | 36.72 | 15.50 | 88 | 43096 | 209951 | 46432927 |
Epstein Barr virus positive mucocutaneous ulcer | 36.01 | 15.50 | 12 | 43172 | 230 | 46642648 |
Blood glucose increased | 35.84 | 15.50 | 11 | 43173 | 72002 | 46570876 |
Oedema peripheral | 35.59 | 15.50 | 58 | 43126 | 159648 | 46483230 |
Klebsiella infection | 35.50 | 15.50 | 37 | 43147 | 6625 | 46636253 |
Unmasking of previously unidentified disease | 35.30 | 15.50 | 16 | 43168 | 715 | 46642163 |
Angiocentric lymphoma | 35.08 | 15.50 | 14 | 43170 | 455 | 46642423 |
Abdominal compartment syndrome | 34.99 | 15.50 | 15 | 43169 | 586 | 46642292 |
Myocardial infarction | 34.48 | 15.50 | 24 | 43160 | 97504 | 46545374 |
Clostridium bacteraemia | 34.29 | 15.50 | 11 | 43173 | 186 | 46642692 |
Palpitations | 34.27 | 15.50 | 23 | 43161 | 95236 | 46547642 |
Hair follicle tumour benign | 34.22 | 15.50 | 13 | 43171 | 369 | 46642509 |
Staphylococcal infection | 34.19 | 15.50 | 91 | 43093 | 35680 | 46607198 |
Pneumatosis intestinalis | 34.07 | 15.50 | 22 | 43162 | 2003 | 46640875 |
Therapeutic product effect decreased | 33.90 | 15.50 | 17 | 43167 | 82584 | 46560294 |
Klebsiella bacteraemia | 33.60 | 15.50 | 18 | 43166 | 1158 | 46641720 |
Oesophageal candidiasis | 33.46 | 15.50 | 32 | 43152 | 5168 | 46637710 |
Alopecia | 33.45 | 15.50 | 62 | 43122 | 162352 | 46480526 |
Staphylococcal sepsis | 33.44 | 15.50 | 38 | 43146 | 7494 | 46635384 |
Bone marrow transplant | 33.42 | 15.50 | 15 | 43169 | 655 | 46642223 |
Pulmonary alveolar haemorrhage | 33.42 | 15.50 | 29 | 43155 | 4133 | 46638745 |
Vision blurred | 33.32 | 15.50 | 16 | 43168 | 79692 | 46563186 |
Weight decreased | 33.28 | 15.50 | 93 | 43091 | 210756 | 46432122 |
Cardiomyopathy acute | 33.19 | 15.50 | 11 | 43173 | 207 | 46642671 |
Hepatosplenomegaly | 32.91 | 15.50 | 23 | 43161 | 2387 | 46640491 |
Sinus polyp | 32.80 | 15.50 | 12 | 43172 | 306 | 46642572 |
Leukoerythroblastosis | 32.52 | 15.50 | 11 | 43173 | 221 | 46642657 |
Subdural hygroma | 32.52 | 15.50 | 11 | 43173 | 221 | 46642657 |
Escherichia bacteraemia | 32.33 | 15.50 | 24 | 43160 | 2737 | 46640141 |
Hypogammaglobulinaemia | 32.25 | 15.50 | 32 | 43152 | 5406 | 46637472 |
Hepatitis B | 32.24 | 15.50 | 27 | 43157 | 3666 | 46639212 |
Inappropriate schedule of product administration | 32.23 | 15.50 | 10 | 43174 | 65003 | 46577875 |
White blood cell count abnormal | 31.93 | 15.50 | 31 | 43153 | 5101 | 46637777 |
Mucocutaneous ulceration | 31.92 | 15.50 | 10 | 43174 | 156 | 46642722 |
Loss of personal independence in daily activities | 31.76 | 15.50 | 7 | 43177 | 57176 | 46585702 |
Stress | 31.43 | 15.50 | 5 | 43179 | 51546 | 46591332 |
Tumour necrosis | 31.33 | 15.50 | 15 | 43169 | 760 | 46642118 |
Gastroenteritis norovirus | 31.28 | 15.50 | 19 | 43165 | 1554 | 46641324 |
Incorrect dose administered | 31.22 | 15.50 | 3 | 43181 | 45547 | 46597331 |
Staphylococcal bacteraemia | 31.22 | 15.50 | 30 | 43154 | 4874 | 46638004 |
Musculoskeletal pain | 31.00 | 15.50 | 13 | 43171 | 70115 | 46572763 |
Therapy non-responder | 30.91 | 15.50 | 96 | 43088 | 41056 | 46601822 |
Respiratory distress | 30.31 | 15.50 | 81 | 43103 | 31835 | 46611043 |
Fungal infection | 30.16 | 15.50 | 77 | 43107 | 29443 | 46613435 |
Metastases to diaphragm | 30.09 | 15.50 | 7 | 43177 | 31 | 46642847 |
Metastases to lung | 30.09 | 15.50 | 43 | 43141 | 10653 | 46632225 |
Venous thrombosis | 30.07 | 15.50 | 29 | 43155 | 4733 | 46638145 |
Loss of consciousness | 29.45 | 15.50 | 34 | 43150 | 108204 | 46534674 |
Pseudomonal sepsis | 29.45 | 15.50 | 20 | 43164 | 1982 | 46640896 |
Device related infection | 29.32 | 15.50 | 62 | 43122 | 20979 | 46621899 |
Parainfluenzae virus infection | 29.08 | 15.50 | 19 | 43165 | 1765 | 46641113 |
Sinusitis | 29.03 | 15.50 | 47 | 43137 | 129721 | 46513157 |
Streptococcal bacteraemia | 29.01 | 15.50 | 17 | 43167 | 1302 | 46641576 |
Bacterial sepsis | 28.93 | 15.50 | 25 | 43159 | 3542 | 46639336 |
Pneumothorax | 28.90 | 15.50 | 50 | 43134 | 14579 | 46628299 |
Respiratory symptom | 28.84 | 15.50 | 20 | 43164 | 2050 | 46640828 |
Tremor | 28.67 | 15.50 | 39 | 43145 | 115600 | 46527278 |
Epiphyses premature fusion | 28.61 | 15.50 | 7 | 43177 | 40 | 46642838 |
Somnolence | 28.61 | 15.50 | 64 | 43120 | 156457 | 46486421 |
Toxic encephalopathy | 28.57 | 15.50 | 29 | 43155 | 5033 | 46637845 |
Pulmonary toxicity | 28.54 | 15.50 | 28 | 43156 | 4665 | 46638213 |
Metastases to central nervous system | 28.51 | 15.50 | 43 | 43141 | 11178 | 46631700 |
Renal failure | 28.30 | 15.50 | 191 | 42993 | 113403 | 46529475 |
Listeriosis | 28.20 | 15.50 | 16 | 43168 | 1153 | 46641725 |
Chronic graft versus host disease | 28.19 | 15.50 | 22 | 43162 | 2703 | 46640175 |
Dry mouth | 28.04 | 15.50 | 8 | 43176 | 54918 | 46587960 |
Drug clearance increased | 28.01 | 15.50 | 8 | 43176 | 89 | 46642789 |
Respiratory syncytial virus infection | 27.84 | 15.50 | 28 | 43156 | 4807 | 46638071 |
Sinoatrial block | 27.61 | 15.50 | 14 | 43170 | 804 | 46642074 |
Hypoglycaemia | 27.59 | 15.50 | 8 | 43176 | 54341 | 46588537 |
International normalised ratio increased | 27.58 | 15.50 | 5 | 43179 | 46878 | 46596000 |
Ejection fraction decreased | 27.52 | 15.50 | 55 | 43129 | 17882 | 46624996 |
Sleep disorder | 27.51 | 15.50 | 5 | 43179 | 46790 | 46596088 |
Ocular vascular disorder | 27.32 | 15.50 | 11 | 43173 | 366 | 46642512 |
Thymus enlargement | 27.31 | 15.50 | 8 | 43176 | 98 | 46642780 |
Mucormycosis | 27.01 | 15.50 | 20 | 43164 | 2272 | 46640606 |
Cytomegalovirus chorioretinitis | 26.92 | 15.50 | 17 | 43167 | 1490 | 46641388 |
Aplastic anaemia | 26.65 | 15.50 | 33 | 43151 | 7120 | 46635758 |
Chronic obstructive pulmonary disease | 26.60 | 15.50 | 10 | 43174 | 57623 | 46585255 |
Delayed puberty | 26.53 | 15.50 | 8 | 43176 | 109 | 46642769 |
Rhinovirus infection | 26.53 | 15.50 | 24 | 43160 | 3612 | 46639266 |
Small cell lung cancer | 26.49 | 15.50 | 17 | 43167 | 1532 | 46641346 |
Injection site reaction | 26.29 | 15.50 | 6 | 43178 | 47843 | 46595035 |
Injection site pruritus | 26.26 | 15.50 | 3 | 43181 | 39740 | 46603138 |
Tonsillar haemorrhage | 26.10 | 15.50 | 9 | 43175 | 192 | 46642686 |
Paraneoplastic neurological syndrome | 26.00 | 15.50 | 5 | 43179 | 6 | 46642872 |
Acute myelomonocytic leukaemia | 25.59 | 15.50 | 9 | 43175 | 204 | 46642674 |
Injury | 25.25 | 15.50 | 5 | 43179 | 44022 | 46598856 |
Histiocytic sarcoma | 25.10 | 15.50 | 7 | 43177 | 71 | 46642807 |
Enteritis | 24.91 | 15.50 | 31 | 43153 | 6724 | 46636154 |
Acute monocytic leukaemia | 24.84 | 15.50 | 7 | 43177 | 74 | 46642804 |
Gastrointestinal toxicity | 24.79 | 15.50 | 25 | 43159 | 4306 | 46638572 |
Myeloproliferative neoplasm | 24.51 | 15.50 | 11 | 43173 | 480 | 46642398 |
Condition aggravated | 24.50 | 15.50 | 130 | 43054 | 244922 | 46397956 |
Hypophosphataemia | 24.32 | 15.50 | 32 | 43152 | 7335 | 46635543 |
Cerebrovascular accident | 24.12 | 15.50 | 35 | 43149 | 101004 | 46541874 |
Metastases to bone marrow | 24.12 | 15.50 | 9 | 43175 | 243 | 46642635 |
Necrotising gastritis | 24.00 | 15.50 | 6 | 43178 | 38 | 46642840 |
Peripheral sensory neuropathy | 23.86 | 15.50 | 30 | 43154 | 6573 | 46636305 |
Toxic neuropathy | 23.68 | 15.50 | 10 | 43174 | 376 | 46642502 |
Neutrophil count abnormal | 23.67 | 15.50 | 19 | 43165 | 2431 | 46640447 |
Spinal cord paralysis | 23.61 | 15.50 | 6 | 43178 | 41 | 46642837 |
Cytogenetic abnormality | 23.55 | 15.50 | 11 | 43173 | 527 | 46642351 |
Cytokine storm | 23.54 | 15.50 | 9 | 43175 | 260 | 46642618 |
Glossodynia | 23.52 | 15.50 | 6 | 43178 | 44367 | 46598511 |
Adverse drug reaction | 23.51 | 15.50 | 6 | 43178 | 44356 | 46598522 |
Vena cava thrombosis | 23.43 | 15.50 | 18 | 43166 | 2161 | 46640717 |
Pericardial effusion | 23.42 | 15.50 | 64 | 43120 | 25479 | 46617399 |
Stenotrophomonas infection | 23.39 | 15.50 | 16 | 43168 | 1604 | 46641274 |
Lower respiratory tract infection | 23.11 | 15.50 | 11 | 43173 | 55078 | 46587800 |
Unevaluable event | 23.07 | 15.50 | 7 | 43177 | 46168 | 46596710 |
Hypoaesthesia | 23.05 | 15.50 | 47 | 43137 | 118822 | 46524056 |
Abortion spontaneous | 22.95 | 15.50 | 6 | 43178 | 43640 | 46599238 |
Respiratory tract infection fungal | 22.94 | 15.50 | 10 | 43174 | 407 | 46642471 |
Vulvovaginal inflammation | 22.91 | 15.50 | 11 | 43173 | 561 | 46642317 |
Nasal congestion | 22.79 | 15.50 | 8 | 43176 | 48105 | 46594773 |
Adrenocortical carcinoma | 22.78 | 15.50 | 6 | 43178 | 48 | 46642830 |
Listeria encephalitis | 22.64 | 15.50 | 8 | 43176 | 184 | 46642694 |
B-cell lymphoma recurrent | 22.60 | 15.50 | 10 | 43174 | 422 | 46642456 |
Diabetes mellitus | 22.58 | 15.50 | 9 | 43175 | 50056 | 46592822 |
Vertigo | 22.45 | 15.50 | 10 | 43174 | 52038 | 46590840 |
Vulvovaginitis | 22.42 | 15.50 | 9 | 43175 | 297 | 46642581 |
Metastases to lymph nodes | 22.19 | 15.50 | 29 | 43155 | 6602 | 46636276 |
Viral haemorrhagic cystitis | 22.19 | 15.50 | 11 | 43173 | 602 | 46642276 |
Acquired gene mutation | 22.14 | 15.50 | 11 | 43173 | 605 | 46642273 |
Iris atrophy | 22.06 | 15.50 | 6 | 43178 | 55 | 46642823 |
Radiation pneumonitis | 22.00 | 15.50 | 14 | 43170 | 1243 | 46641635 |
Urinary tract infection bacterial | 21.95 | 15.50 | 23 | 43161 | 4142 | 46638736 |
Genotoxicity | 21.91 | 15.50 | 5 | 43179 | 20 | 46642858 |
Ependymoma | 21.87 | 15.50 | 6 | 43178 | 57 | 46642821 |
Metastases to spleen | 21.84 | 15.50 | 7 | 43177 | 118 | 46642760 |
Neck pain | 21.78 | 15.50 | 12 | 43172 | 55294 | 46587584 |
Congenital retinoblastoma | 21.71 | 15.50 | 5 | 43179 | 21 | 46642857 |
Paranasal sinus mucosal hypertrophy | 21.71 | 15.50 | 5 | 43179 | 21 | 46642857 |
Burning sensation | 21.71 | 15.50 | 7 | 43177 | 44404 | 46598474 |
Follicular thyroid cancer | 21.68 | 15.50 | 6 | 43178 | 59 | 46642819 |
Splenomegaly | 21.65 | 15.50 | 35 | 43149 | 9653 | 46633225 |
Plasma cell myeloma | 21.62 | 15.50 | 90 | 43094 | 44388 | 46598490 |
Suicide attempt | 21.58 | 15.50 | 12 | 43172 | 55024 | 46587854 |
Retroperitoneal abscess | 21.57 | 15.50 | 7 | 43177 | 123 | 46642755 |
Pseudomonas infection | 21.47 | 15.50 | 35 | 43149 | 9723 | 46633155 |
Metastasis | 21.29 | 15.50 | 23 | 43161 | 4289 | 46638589 |
Retinal pigment epitheliopathy | 21.23 | 15.50 | 8 | 43176 | 222 | 46642656 |
Primary mediastinal large B-cell lymphoma recurrent | 21.07 | 15.50 | 6 | 43178 | 66 | 46642812 |
Gliosis | 20.93 | 15.50 | 8 | 43176 | 231 | 46642647 |
Depressed mood | 20.84 | 15.50 | 3 | 43181 | 33316 | 46609562 |
Neutropenic infection | 20.73 | 15.50 | 13 | 43171 | 1125 | 46641753 |
Congestive cardiomyopathy | 20.72 | 15.50 | 26 | 43158 | 5687 | 46637191 |
Serum ferritin increased | 20.70 | 15.50 | 25 | 43159 | 5258 | 46637620 |
Trichosporon infection | 20.61 | 15.50 | 8 | 43176 | 241 | 46642637 |
Ganglioneuroma | 20.59 | 15.50 | 7 | 43177 | 143 | 46642735 |
Blood stem cell transplant failure | 20.36 | 15.50 | 7 | 43177 | 148 | 46642730 |
Lung infiltration | 20.29 | 15.50 | 42 | 43142 | 14001 | 46628877 |
Ewing's sarcoma | 20.29 | 15.50 | 4 | 43180 | 6 | 46642872 |
Pneumocystis jirovecii pneumonia | 20.17 | 15.50 | 44 | 43140 | 15204 | 46627674 |
Blood cholesterol increased | 20.11 | 15.50 | 6 | 43178 | 40007 | 46602871 |
VIth nerve paresis | 20.09 | 15.50 | 6 | 43178 | 79 | 46642799 |
Discomfort | 20.07 | 15.50 | 9 | 43175 | 46661 | 46596217 |
Radiation oesophagitis | 20.04 | 15.50 | 8 | 43176 | 260 | 46642618 |
Gastrointestinal mucosal disorder | 20.00 | 15.50 | 11 | 43173 | 746 | 46642132 |
Enterobacter bacteraemia | 19.98 | 15.50 | 8 | 43176 | 262 | 46642616 |
Vaccination failure | 19.88 | 15.50 | 6 | 43178 | 82 | 46642796 |
Wrong technique in product usage process | 19.76 | 15.50 | 13 | 43171 | 54409 | 46588469 |
Therapy partial responder | 19.74 | 15.50 | 23 | 43161 | 4659 | 46638219 |
Central nervous system lymphoma | 19.58 | 15.50 | 13 | 43171 | 1241 | 46641637 |
Metastases to breast | 19.51 | 15.50 | 8 | 43176 | 279 | 46642599 |
Plasmacytoma | 19.36 | 15.50 | 17 | 43167 | 2460 | 46640418 |
Enterocolitis | 19.14 | 15.50 | 26 | 43158 | 6142 | 46636736 |
Clostridium colitis | 19.05 | 15.50 | 15 | 43169 | 1867 | 46641011 |
Oral fungal infection | 19.03 | 15.50 | 17 | 43167 | 2517 | 46640361 |
Balance disorder | 18.95 | 15.50 | 19 | 43165 | 64502 | 46578376 |
Fluid retention | 18.79 | 15.50 | 12 | 43172 | 51034 | 46591844 |
Hypomagnesaemia | 18.74 | 15.50 | 54 | 43130 | 22156 | 46620722 |
B precursor type acute leukaemia | 18.69 | 15.50 | 7 | 43177 | 191 | 46642687 |
Lymphoma | 18.68 | 15.50 | 33 | 43151 | 9780 | 46633098 |
Pulmonary vascular disorder | 18.58 | 15.50 | 8 | 43176 | 316 | 46642562 |
Gestational trophoblastic tumour | 18.56 | 15.50 | 5 | 43179 | 44 | 46642834 |
Product quality issue | 18.55 | 15.50 | 5 | 43179 | 35643 | 46607235 |
Mucosal erosion | 18.30 | 15.50 | 13 | 43171 | 1385 | 46641493 |
Refractory cancer | 18.17 | 15.50 | 5 | 43179 | 48 | 46642830 |
Transdifferentiation of neoplasm | 18.17 | 15.50 | 4 | 43180 | 13 | 46642865 |
Vascular compression | 18.05 | 15.50 | 6 | 43178 | 114 | 46642764 |
Amnesia | 17.95 | 15.50 | 8 | 43176 | 41623 | 46601255 |
Neuroblastoma | 17.90 | 15.50 | 5 | 43179 | 51 | 46642827 |
Peripheral motor neuropathy | 17.66 | 15.50 | 13 | 43171 | 1463 | 46641415 |
Impaired healing | 17.59 | 15.50 | 6 | 43178 | 36737 | 46606141 |
Engraft failure | 17.56 | 15.50 | 8 | 43176 | 362 | 46642516 |
Hypoglossal nerve paresis | 17.49 | 15.50 | 6 | 43178 | 126 | 46642752 |
Rectal fissure | 17.49 | 15.50 | 9 | 43175 | 533 | 46642345 |
Cardiopulmonary failure | 17.12 | 15.50 | 19 | 43165 | 3650 | 46639228 |
Respiratory arrest | 17.12 | 15.50 | 5 | 43179 | 33811 | 46609067 |
Carcinoid crisis | 17.10 | 15.50 | 7 | 43177 | 243 | 46642635 |
Surgery | 17.08 | 15.50 | 3 | 43181 | 28782 | 46614096 |
Coronary artery disease | 17.07 | 15.50 | 5 | 43179 | 33747 | 46609131 |
Constipation | 17.03 | 15.50 | 93 | 43091 | 174004 | 46468874 |
B-cell lymphoma | 17.02 | 15.50 | 18 | 43166 | 3276 | 46639602 |
Myelopathy | 16.98 | 15.50 | 16 | 43168 | 2536 | 46640342 |
Salivary gland cancer | 16.98 | 15.50 | 6 | 43178 | 138 | 46642740 |
Lung consolidation | 16.71 | 15.50 | 19 | 43165 | 3748 | 46639130 |
Rhabdomyolysis | 16.63 | 15.50 | 9 | 43175 | 41900 | 46600978 |
Cardiomyopathy | 16.49 | 15.50 | 42 | 43142 | 16031 | 46626847 |
Drug clearance decreased | 16.35 | 15.50 | 11 | 43173 | 1073 | 46641805 |
Schistocytosis | 16.33 | 15.50 | 4 | 43180 | 23 | 46642855 |
Streptococcal sepsis | 16.27 | 15.50 | 13 | 43171 | 1652 | 46641226 |
Chest pain | 16.27 | 15.50 | 96 | 43088 | 176228 | 46466650 |
Meningoencephalitis bacterial | 16.27 | 15.50 | 5 | 43179 | 73 | 46642805 |
Dry eye | 16.26 | 15.50 | 4 | 43180 | 30318 | 46612560 |
Intra-abdominal haemorrhage | 16.26 | 15.50 | 15 | 43169 | 2315 | 46640563 |
Product administered to patient of inappropriate age | 16.24 | 15.50 | 16 | 43168 | 2680 | 46640198 |
Blood creatine phosphokinase increased | 16.21 | 15.50 | 3 | 43181 | 27721 | 46615157 |
Gastroenteritis cryptosporidial | 16.20 | 15.50 | 5 | 43179 | 74 | 46642804 |
Rhabdomyosarcoma recurrent | 16.19 | 15.50 | 4 | 43180 | 24 | 46642854 |
Odynophagia | 16.18 | 15.50 | 25 | 43159 | 6637 | 46636241 |
Flagellate dermatitis | 16.15 | 15.50 | 6 | 43178 | 160 | 46642718 |
Hyperkalaemia | 15.99 | 15.50 | 14 | 43170 | 50695 | 46592183 |
Low cardiac output syndrome | 15.99 | 15.50 | 7 | 43177 | 288 | 46642590 |
Glioblastoma multiforme | 15.94 | 15.50 | 10 | 43174 | 866 | 46642012 |
Hypoxia | 15.92 | 15.50 | 92 | 43092 | 51746 | 46591132 |
Sinusitis fungal | 15.92 | 15.50 | 10 | 43174 | 868 | 46642010 |
Osteosarcoma metastatic | 15.91 | 15.50 | 4 | 43180 | 26 | 46642852 |
Platelet count abnormal | 15.86 | 15.50 | 16 | 43168 | 2756 | 46640122 |
Pneumonia klebsiella | 15.83 | 15.50 | 14 | 43170 | 2045 | 46640833 |
Osteonecrosis of jaw | 15.82 | 15.50 | 6 | 43178 | 34396 | 46608482 |
Traumatic lung injury | 15.79 | 15.50 | 12 | 43172 | 1418 | 46641460 |
Vomiting | 15.71 | 15.50 | 538 | 42646 | 452256 | 46190622 |
Pneumonia respiratory syncytial viral | 15.62 | 15.50 | 9 | 43175 | 668 | 46642210 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 2438.96 | 13.73 | 1883 | 58563 | 104810 | 29787222 |
Neutropenia | 877.11 | 13.73 | 1182 | 59264 | 127358 | 29764674 |
Bone marrow failure | 661.70 | 13.73 | 519 | 59927 | 29266 | 29862766 |
Mucosal inflammation | 644.50 | 13.73 | 516 | 59930 | 29978 | 29862054 |
Acute myeloid leukaemia | 601.70 | 13.73 | 402 | 60044 | 17604 | 29874428 |
Product use in unapproved indication | 571.79 | 13.73 | 723 | 59723 | 72970 | 29819062 |
Pancytopenia | 560.38 | 13.73 | 770 | 59676 | 84282 | 29807750 |
Myelodysplastic syndrome | 489.22 | 13.73 | 360 | 60086 | 18418 | 29873614 |
Thrombocytopenia | 435.83 | 13.73 | 895 | 59551 | 136149 | 29755883 |
Off label use | 433.95 | 13.73 | 1291 | 59155 | 247999 | 29644033 |
Venoocclusive liver disease | 333.54 | 13.73 | 192 | 60254 | 6421 | 29885611 |
Haematotoxicity | 305.49 | 13.73 | 177 | 60269 | 5993 | 29886039 |
Second primary malignancy | 284.95 | 13.73 | 171 | 60275 | 6185 | 29885847 |
Myelosuppression | 272.55 | 13.73 | 175 | 60271 | 7147 | 29884885 |
Malignant neoplasm progression | 259.13 | 13.73 | 497 | 59949 | 71790 | 29820242 |
Febrile bone marrow aplasia | 240.03 | 13.73 | 168 | 60278 | 7929 | 29884103 |
Sepsis | 229.19 | 13.73 | 732 | 59714 | 145663 | 29746369 |
Haemophagocytic lymphohistiocytosis | 222.31 | 13.73 | 173 | 60273 | 9618 | 29882414 |
Tumour lysis syndrome | 218.10 | 13.73 | 192 | 60254 | 12693 | 29879339 |
Septic shock | 209.32 | 13.73 | 422 | 60024 | 63185 | 29828847 |
Leukopenia | 187.63 | 13.73 | 375 | 60071 | 55784 | 29836248 |
Fall | 178.48 | 13.73 | 72 | 60374 | 181800 | 29710232 |
Neoplasm progression | 165.67 | 13.73 | 193 | 60253 | 17830 | 29874202 |
Neutropenic sepsis | 165.65 | 13.73 | 156 | 60290 | 11253 | 29880779 |
Disease progression | 158.66 | 13.73 | 435 | 60011 | 79439 | 29812593 |
Diffuse large B-cell lymphoma recurrent | 150.84 | 13.73 | 77 | 60369 | 2015 | 29890017 |
Neutrophil count decreased | 144.76 | 13.73 | 286 | 60160 | 42168 | 29849864 |
Pyrexia | 140.79 | 13.73 | 1045 | 59401 | 293444 | 29598588 |
Product dose omission issue | 137.65 | 13.73 | 13 | 60433 | 91618 | 29800414 |
Diffuse large B-cell lymphoma | 137.01 | 13.73 | 119 | 60327 | 7722 | 29884310 |
Malignant transformation | 136.00 | 13.73 | 52 | 60394 | 661 | 29891371 |
Fatigue | 135.38 | 13.73 | 278 | 60168 | 320395 | 29571637 |
Bronchopulmonary aspergillosis | 132.50 | 13.73 | 143 | 60303 | 12141 | 29879891 |
Cardiotoxicity | 131.77 | 13.73 | 92 | 60354 | 4322 | 29887710 |
Diffuse large B-cell lymphoma refractory | 131.66 | 13.73 | 52 | 60394 | 725 | 29891307 |
Posterior reversible encephalopathy syndrome | 130.13 | 13.73 | 121 | 60325 | 8586 | 29883446 |
Venoocclusive disease | 127.39 | 13.73 | 74 | 60372 | 2516 | 29889516 |
Aspergillus infection | 126.45 | 13.73 | 128 | 60318 | 10086 | 29881946 |
Aplasia | 124.87 | 13.73 | 86 | 60360 | 3951 | 29888081 |
Dizziness | 124.50 | 13.73 | 126 | 60320 | 194783 | 29697249 |
Stem cell transplant | 124.07 | 13.73 | 68 | 60378 | 2063 | 29889969 |
Stomatitis | 122.11 | 13.73 | 247 | 60199 | 37032 | 29855000 |
Cytopenia | 121.98 | 13.73 | 114 | 60332 | 8142 | 29883890 |
Neoplasm recurrence | 109.87 | 13.73 | 60 | 60386 | 1807 | 29890225 |
Overdose | 109.73 | 13.73 | 19 | 60427 | 84318 | 29807714 |
Acute graft versus host disease | 108.56 | 13.73 | 92 | 60354 | 5772 | 29886260 |
Depression | 108.02 | 13.73 | 25 | 60421 | 90412 | 29801620 |
Therapy partial responder | 108.01 | 13.73 | 76 | 60370 | 3615 | 29888417 |
Insomnia | 107.20 | 13.73 | 28 | 60418 | 93308 | 29798724 |
Malaise | 98.73 | 13.73 | 115 | 60331 | 166847 | 29725185 |
Cystitis haemorrhagic | 96.71 | 13.73 | 79 | 60367 | 4708 | 29887324 |
Encephalopathy | 95.65 | 13.73 | 205 | 60241 | 32000 | 29860032 |
Acute lymphocytic leukaemia | 89.30 | 13.73 | 63 | 60383 | 3009 | 29889023 |
Arthralgia | 88.66 | 13.73 | 86 | 60360 | 135705 | 29756327 |
Drug interaction | 88.31 | 13.73 | 168 | 60278 | 199400 | 29692632 |
Disease recurrence | 85.18 | 13.73 | 123 | 60323 | 14038 | 29877994 |
Death | 85.02 | 13.73 | 402 | 60044 | 356881 | 29535151 |
Neutropenic colitis | 84.70 | 13.73 | 54 | 60392 | 2176 | 29889856 |
Neurotoxicity | 84.46 | 13.73 | 118 | 60328 | 13064 | 29878968 |
Pain | 83.90 | 13.73 | 137 | 60309 | 172504 | 29719528 |
Rash | 83.62 | 13.73 | 163 | 60283 | 191726 | 29700306 |
Peripheral swelling | 83.40 | 13.73 | 12 | 60434 | 61062 | 29830970 |
Tremor | 82.08 | 13.73 | 25 | 60421 | 75338 | 29816694 |
Fungal infection | 81.61 | 13.73 | 118 | 60328 | 13482 | 29878550 |
Joint swelling | 81.45 | 13.73 | 3 | 60443 | 46943 | 29845089 |
Cytomegalovirus infection | 81.27 | 13.73 | 160 | 60286 | 23514 | 29868518 |
Colitis | 81.18 | 13.73 | 187 | 60259 | 30633 | 29861399 |
Anxiety | 81.07 | 13.73 | 40 | 60406 | 89831 | 29802201 |
Bacteraemia | 80.55 | 13.73 | 126 | 60320 | 15434 | 29876598 |
Anaemia | 80.48 | 13.73 | 704 | 59742 | 207288 | 29684744 |
Blood pressure increased | 79.91 | 13.73 | 23 | 60423 | 71905 | 29820127 |
Sweat gland tumour | 77.37 | 13.73 | 30 | 60416 | 397 | 29891635 |
Cardiac failure congestive | 76.99 | 13.73 | 37 | 60409 | 84370 | 29807662 |
Multiple organ dysfunction syndrome | 75.24 | 13.73 | 290 | 60156 | 63197 | 29828835 |
Respiratory failure | 73.17 | 13.73 | 398 | 60048 | 100244 | 29791788 |
Anaplastic lymphoma kinase gene mutation | 70.61 | 13.73 | 20 | 60426 | 88 | 29891944 |
Coronary artery disease | 69.69 | 13.73 | 9 | 60437 | 49703 | 29842329 |
Myocardial infarction | 66.47 | 13.73 | 94 | 60352 | 125531 | 29766501 |
Progressive multifocal leukoencephalopathy | 65.83 | 13.73 | 86 | 60360 | 8927 | 29883105 |
Chloroma | 62.35 | 13.73 | 26 | 60420 | 420 | 29891612 |
Pulmonary toxicity | 62.21 | 13.73 | 60 | 60386 | 4456 | 29887576 |
Lymphopenia | 60.50 | 13.73 | 101 | 60345 | 13062 | 29878970 |
Systemic mycosis | 60.48 | 13.73 | 35 | 60411 | 1181 | 29890851 |
Adenovirus infection | 59.35 | 13.73 | 57 | 60389 | 4211 | 29887821 |
Blood glucose increased | 59.18 | 13.73 | 25 | 60421 | 61505 | 29830527 |
Hepatitis B | 59.10 | 13.73 | 67 | 60379 | 6005 | 29886027 |
Candida infection | 59.10 | 13.73 | 109 | 60337 | 15253 | 29876779 |
Acute promyelocytic leukaemia | 59.09 | 13.73 | 27 | 60419 | 549 | 29891483 |
Pruritus | 59.07 | 13.73 | 92 | 60354 | 118112 | 29773920 |
Nasopharyngitis | 58.08 | 13.73 | 23 | 60423 | 58826 | 29833206 |
Enterococcal bacteraemia | 58.07 | 13.73 | 36 | 60410 | 1380 | 29890652 |
Weight decreased | 57.55 | 13.73 | 138 | 60308 | 150783 | 29741249 |
Chronic graft versus host disease | 57.26 | 13.73 | 55 | 60391 | 4064 | 29887968 |
White blood cell count decreased | 57.01 | 13.73 | 326 | 60120 | 83621 | 29808411 |
Epstein-Barr virus infection | 56.96 | 13.73 | 69 | 60377 | 6637 | 29885395 |
Weight increased | 56.78 | 13.73 | 41 | 60405 | 74872 | 29817160 |
Epstein-Barr virus associated lymphoproliferative disorder | 56.26 | 13.73 | 38 | 60408 | 1690 | 29890342 |
Drug resistance | 56.17 | 13.73 | 125 | 60321 | 20008 | 29872024 |
Aggression | 56.02 | 13.73 | 5 | 60441 | 36902 | 29855130 |
Hypoglycaemia | 55.34 | 13.73 | 17 | 60429 | 50964 | 29841068 |
Headache | 55.31 | 13.73 | 186 | 60260 | 182120 | 29709912 |
Osteosarcoma | 54.97 | 13.73 | 19 | 60427 | 177 | 29891855 |
Acute graft versus host disease in skin | 54.81 | 13.73 | 56 | 60390 | 4460 | 29887572 |
Chest pain | 54.64 | 13.73 | 96 | 60350 | 117531 | 29774501 |
Musculoskeletal stiffness | 54.08 | 13.73 | 5 | 60441 | 35876 | 29856156 |
Azoospermia | 53.67 | 13.73 | 23 | 60423 | 399 | 29891633 |
Enterococcal infection | 53.24 | 13.73 | 74 | 60372 | 8150 | 29883882 |
Somnolence | 52.57 | 13.73 | 71 | 60375 | 96692 | 29795340 |
Bacterial sepsis | 52.50 | 13.73 | 57 | 60389 | 4869 | 29887163 |
Oedema peripheral | 52.27 | 13.73 | 83 | 60363 | 105749 | 29786283 |
Myalgia | 51.82 | 13.73 | 47 | 60399 | 76620 | 29815412 |
Renal tubular disorder | 51.75 | 13.73 | 57 | 60389 | 4949 | 29887083 |
Feeling abnormal | 51.55 | 13.73 | 25 | 60421 | 56731 | 29835301 |
Inappropriate schedule of product administration | 51.53 | 13.73 | 9 | 60437 | 39719 | 29852313 |
Vena cava thrombosis | 51.42 | 13.73 | 30 | 60416 | 1028 | 29891004 |
Neuropathy peripheral | 51.37 | 13.73 | 279 | 60167 | 70196 | 29821836 |
Pneumonitis | 50.94 | 13.73 | 146 | 60300 | 27308 | 29864724 |
Ameloblastoma | 50.75 | 13.73 | 15 | 60431 | 79 | 29891953 |
Nephropathy toxic | 50.73 | 13.73 | 83 | 60363 | 10556 | 29881476 |
Blood stem cell transplant failure | 50.24 | 13.73 | 22 | 60424 | 403 | 29891629 |
Psoriasis | 50.22 | 13.73 | 12 | 60434 | 42494 | 29849538 |
Staphylococcal bacteraemia | 50.08 | 13.73 | 65 | 60381 | 6703 | 29885329 |
Cytomegalovirus chorioretinitis | 49.96 | 13.73 | 46 | 60400 | 3222 | 29888810 |
Pulmonary vascular disorder | 49.87 | 13.73 | 21 | 60425 | 348 | 29891684 |
Cerebrovascular accident | 49.80 | 13.73 | 57 | 60389 | 83420 | 29808612 |
Muscle spasms | 49.77 | 13.73 | 35 | 60411 | 64803 | 29827229 |
Asthma | 49.63 | 13.73 | 7 | 60439 | 36167 | 29855865 |
Ependymoma | 48.81 | 13.73 | 14 | 60432 | 65 | 29891967 |
Small cell lung cancer | 48.81 | 13.73 | 36 | 60410 | 1844 | 29890188 |
Neuroblastoma | 48.01 | 13.73 | 18 | 60428 | 216 | 29891816 |
Rheumatoid arthritis | 47.95 | 13.73 | 12 | 60434 | 41185 | 29850847 |
Hyperkalaemia | 47.62 | 13.73 | 38 | 60408 | 65972 | 29826060 |
B-cell lymphoma recurrent | 47.32 | 13.73 | 24 | 60422 | 619 | 29891413 |
Diaphragm muscle weakness | 47.01 | 13.73 | 14 | 60432 | 76 | 29891956 |
Hepatitis B reactivation | 46.93 | 13.73 | 42 | 60404 | 2835 | 29889197 |
Pneumocystis jirovecii pneumonia | 46.31 | 13.73 | 105 | 60341 | 17015 | 29875017 |
Acute respiratory distress syndrome | 45.67 | 13.73 | 127 | 60319 | 23345 | 29868687 |
Graft versus host disease | 45.47 | 13.73 | 77 | 60369 | 10073 | 29881959 |
Rhabdomyolysis | 45.37 | 13.73 | 37 | 60409 | 63543 | 29828489 |
Platelet count decreased | 45.02 | 13.73 | 367 | 60079 | 105762 | 29786270 |
Klebsiella sepsis | 44.85 | 13.73 | 33 | 60413 | 1684 | 29890348 |
Medulloblastoma recurrent | 44.71 | 13.73 | 13 | 60433 | 64 | 29891968 |
Clostridium difficile colitis | 44.66 | 13.73 | 87 | 60359 | 12681 | 29879351 |
Hospitalisation | 44.26 | 13.73 | 17 | 60429 | 44302 | 29847730 |
Retinal haemorrhage | 43.91 | 13.73 | 51 | 60395 | 4692 | 29887340 |
T-cell type acute leukaemia | 43.84 | 13.73 | 16 | 60430 | 177 | 29891855 |
Fusarium infection | 43.51 | 13.73 | 27 | 60419 | 1037 | 29890995 |
Pain in extremity | 43.42 | 13.73 | 99 | 60347 | 110122 | 29781910 |
Pneumonia klebsiella | 42.62 | 13.73 | 38 | 60408 | 2552 | 29889480 |
Chronic obstructive pulmonary disease | 42.37 | 13.73 | 20 | 60426 | 46106 | 29845926 |
Urinary tract infection | 42.11 | 13.73 | 52 | 60394 | 73607 | 29818425 |
Papillary thyroid cancer | 41.67 | 13.73 | 22 | 60424 | 618 | 29891414 |
Refractory cancer | 41.63 | 13.73 | 14 | 60432 | 119 | 29891913 |
Hypogammaglobulinaemia | 41.32 | 13.73 | 52 | 60394 | 5200 | 29886832 |
Drug hypersensitivity | 40.63 | 13.73 | 47 | 60399 | 68472 | 29823560 |
Blood creatine phosphokinase increased | 40.30 | 13.73 | 19 | 60427 | 43829 | 29848203 |
Influenza like illness | 40.15 | 13.73 | 3 | 60443 | 25602 | 29866430 |
Lymphadenopathy | 39.88 | 13.73 | 124 | 60322 | 24252 | 29867780 |
Gait disturbance | 39.47 | 13.73 | 56 | 60390 | 74721 | 29817311 |
Incorrect dose administered | 39.34 | 13.73 | 8 | 60438 | 31678 | 29860354 |
Escherichia bacteraemia | 38.93 | 13.73 | 38 | 60408 | 2864 | 29889168 |
Central nervous system fungal infection | 38.68 | 13.73 | 16 | 60430 | 253 | 29891779 |
Recurrent cancer | 38.62 | 13.73 | 26 | 60420 | 1150 | 29890882 |
Systemic candida | 38.59 | 13.73 | 37 | 60409 | 2727 | 29889305 |
Agranulocytosis | 38.13 | 13.73 | 114 | 60332 | 21828 | 29870204 |
Hallucination | 36.97 | 13.73 | 27 | 60419 | 49032 | 29843000 |
Thrombotic microangiopathy | 36.84 | 13.73 | 64 | 60382 | 8546 | 29883486 |
Metastasis | 36.62 | 13.73 | 39 | 60407 | 3259 | 29888773 |
Engraftment syndrome | 36.26 | 13.73 | 22 | 60424 | 811 | 29891221 |
Haematochezia | 36.09 | 13.73 | 12 | 60434 | 34210 | 29857822 |
Pulmonary arteriopathy | 36.01 | 13.73 | 11 | 60435 | 66 | 29891966 |
Testicular germ cell cancer metastatic | 35.87 | 13.73 | 11 | 60435 | 67 | 29891965 |
Drug reaction with eosinophilia and systemic symptoms | 35.77 | 13.73 | 7 | 60439 | 28481 | 29863551 |
Hyperhidrosis | 35.65 | 13.73 | 50 | 60396 | 67040 | 29824992 |
Sleep disorder | 35.36 | 13.73 | 4 | 60442 | 24475 | 29867557 |
Arthritis | 35.22 | 13.73 | 4 | 60442 | 24397 | 29867635 |
Balance disorder | 34.81 | 13.73 | 15 | 60431 | 36478 | 29855554 |
Cytogenetic abnormality | 34.64 | 13.73 | 21 | 60425 | 773 | 29891259 |
Ganglioneuroblastoma | 34.45 | 13.73 | 9 | 60437 | 27 | 29892005 |
Vision blurred | 34.21 | 13.73 | 21 | 60425 | 41795 | 29850237 |
Peripheral T-cell lymphoma unspecified | 33.98 | 13.73 | 18 | 60428 | 509 | 29891523 |
Delayed puberty | 33.94 | 13.73 | 13 | 60433 | 166 | 29891866 |
Unevaluable event | 33.77 | 13.73 | 11 | 60435 | 31774 | 29860258 |
Nephrolithiasis | 33.57 | 13.73 | 5 | 60441 | 24805 | 29867227 |
Mucormycosis | 33.50 | 13.73 | 47 | 60399 | 5221 | 29886811 |
Cellulitis gangrenous | 33.39 | 13.73 | 13 | 60433 | 174 | 29891858 |
Fanconi syndrome | 33.16 | 13.73 | 28 | 60418 | 1747 | 29890285 |
Loss of consciousness | 33.14 | 13.73 | 69 | 60377 | 79306 | 29812726 |
Osteonecrosis | 33.08 | 13.73 | 89 | 60357 | 16046 | 29875986 |
Metastases to liver | 33.04 | 13.73 | 74 | 60372 | 11891 | 29880141 |
Angioedema | 33.01 | 13.73 | 14 | 60432 | 34370 | 29857662 |
Abdominal discomfort | 32.85 | 13.73 | 30 | 60416 | 48761 | 29843271 |
Human herpesvirus 6 infection | 32.76 | 13.73 | 29 | 60417 | 1929 | 29890103 |
Medulloblastoma | 32.46 | 13.73 | 10 | 60436 | 62 | 29891970 |
Juvenile melanoma benign | 32.06 | 13.73 | 10 | 60436 | 65 | 29891967 |
Escherichia infection | 31.94 | 13.73 | 51 | 60395 | 6354 | 29885678 |
Bradycardia | 31.76 | 13.73 | 52 | 60394 | 65474 | 29826558 |
Dyspnoea | 31.32 | 13.73 | 479 | 59967 | 332816 | 29559216 |
Stenotrophomonas infection | 31.13 | 13.73 | 26 | 60420 | 1598 | 29890434 |
Urticaria | 30.73 | 13.73 | 39 | 60407 | 54567 | 29837465 |
Primitive neuroectodermal tumour | 30.71 | 13.73 | 10 | 60436 | 76 | 29891956 |
Toxic encephalopathy | 30.63 | 13.73 | 42 | 60404 | 4567 | 29887465 |
Carotid artery thrombosis | 30.60 | 13.73 | 15 | 60431 | 359 | 29891673 |
Pancreatic neuroendocrine tumour metastatic | 30.47 | 13.73 | 12 | 60434 | 166 | 29891866 |
Therapy non-responder | 30.44 | 13.73 | 129 | 60317 | 29324 | 29862708 |
Extravasation | 30.44 | 13.73 | 27 | 60419 | 1801 | 29890231 |
Acute lymphocytic leukaemia recurrent | 30.43 | 13.73 | 32 | 60414 | 2635 | 29889397 |
Injury | 30.29 | 13.73 | 4 | 60442 | 21727 | 29870305 |
Minimal residual disease | 30.26 | 13.73 | 13 | 60433 | 227 | 29891805 |
Leukaemia recurrent | 29.94 | 13.73 | 25 | 60421 | 1536 | 29890496 |
Salivary gland cancer | 29.85 | 13.73 | 13 | 60433 | 235 | 29891797 |
Aortic thrombosis | 29.58 | 13.73 | 18 | 60428 | 667 | 29891365 |
Back pain | 29.50 | 13.73 | 107 | 60339 | 102489 | 29789543 |
Hepatotoxicity | 29.40 | 13.73 | 92 | 60354 | 18053 | 29873979 |
Body height below normal | 29.35 | 13.73 | 13 | 60433 | 245 | 29891787 |
Enteritis | 29.22 | 13.73 | 50 | 60396 | 6595 | 29885437 |
Cardio-respiratory arrest | 29.17 | 13.73 | 44 | 60402 | 57262 | 29834770 |
Rhabdomyosarcoma recurrent | 29.14 | 13.73 | 10 | 60436 | 91 | 29891941 |
Teratoma | 29.13 | 13.73 | 7 | 60439 | 13 | 29892019 |
Renal salt-wasting syndrome | 29.04 | 13.73 | 11 | 60435 | 136 | 29891896 |
Eosinophilia | 28.78 | 13.73 | 5 | 60441 | 22155 | 29869877 |
Nervous system disorder | 28.74 | 13.73 | 74 | 60372 | 12995 | 29879037 |
Memory impairment | 28.60 | 13.73 | 20 | 60426 | 37154 | 29854878 |
Embolism | 28.56 | 13.73 | 51 | 60395 | 6958 | 29885074 |
Capillary leak syndrome | 28.45 | 13.73 | 25 | 60421 | 1647 | 29890385 |
Aspiration bone marrow abnormal | 28.21 | 13.73 | 10 | 60436 | 101 | 29891931 |
Metastases to retroperitoneum | 28.11 | 13.73 | 12 | 60434 | 206 | 29891826 |
Electrocardiogram QT prolonged | 27.95 | 13.73 | 19 | 60427 | 35816 | 29856216 |
Diabetes mellitus | 27.87 | 13.73 | 26 | 60420 | 41839 | 29850193 |
Encephalitis enteroviral | 27.87 | 13.73 | 11 | 60435 | 153 | 29891879 |
Metastases to lung | 27.86 | 13.73 | 54 | 60392 | 7841 | 29884191 |
Hepatic infection fungal | 27.81 | 13.73 | 11 | 60435 | 154 | 29891878 |
High-grade B-cell lymphoma | 27.74 | 13.73 | 11 | 60435 | 155 | 29891877 |
Loss of personal independence in daily activities | 27.66 | 13.73 | 5 | 60441 | 21530 | 29870502 |
Cardiac disorder | 27.49 | 13.73 | 24 | 60422 | 39869 | 29852163 |
Intestinal atresia | 27.24 | 13.73 | 9 | 60437 | 72 | 29891960 |
Pulmonary haemorrhage | 26.96 | 13.73 | 59 | 60387 | 9333 | 29882699 |
Refractory anaemia with an excess of blasts | 26.89 | 13.73 | 14 | 60432 | 382 | 29891650 |
Short stature | 26.78 | 13.73 | 8 | 60438 | 44 | 29891988 |
Hepatic candidiasis | 26.48 | 13.73 | 8 | 60438 | 46 | 29891986 |
Neutrophil count abnormal | 26.33 | 13.73 | 22 | 60424 | 1353 | 29890679 |
Bacterial infection | 26.30 | 13.73 | 70 | 60376 | 12540 | 29879492 |
Hypophosphataemia | 26.22 | 13.73 | 54 | 60392 | 8191 | 29883841 |
Candida sepsis | 26.20 | 13.73 | 20 | 60426 | 1079 | 29890953 |
Mantle cell lymphoma recurrent | 26.02 | 13.73 | 14 | 60432 | 409 | 29891623 |
Cardiac arrest | 25.92 | 13.73 | 98 | 60348 | 92752 | 29799280 |
Cytokine release syndrome | 25.84 | 13.73 | 60 | 60386 | 9873 | 29882159 |
Abdominal pain upper | 25.58 | 13.73 | 55 | 60391 | 62496 | 29829536 |
Device related infection | 25.50 | 13.73 | 84 | 60362 | 16931 | 29875101 |
Bicytopenia | 25.39 | 13.73 | 24 | 60422 | 1738 | 29890294 |
Trichosporon infection | 25.27 | 13.73 | 16 | 60430 | 637 | 29891395 |
Pulmonary veno-occlusive disease | 25.18 | 13.73 | 14 | 60432 | 437 | 29891595 |
Intussusception | 25.14 | 13.73 | 15 | 60431 | 536 | 29891496 |
Graft versus host disease in gastrointestinal tract | 25.12 | 13.73 | 31 | 60415 | 3038 | 29888994 |
Metastases to muscle | 25.10 | 13.73 | 11 | 60435 | 202 | 29891830 |
Lactic acidosis | 25.08 | 13.73 | 16 | 60430 | 31197 | 29860835 |
Metastases to central nervous system | 24.71 | 13.73 | 49 | 60397 | 7235 | 29884797 |
Pneumocystis jirovecii infection | 24.68 | 13.73 | 21 | 60425 | 1324 | 29890708 |
Hypoalbuminaemia | 24.59 | 13.73 | 63 | 60383 | 11029 | 29881003 |
Pneumonia aspiration | 24.52 | 13.73 | 24 | 60422 | 37756 | 29854276 |
Disseminated intravascular coagulation | 24.39 | 13.73 | 99 | 60347 | 22072 | 29869960 |
Geotrichum infection | 24.36 | 13.73 | 14 | 60432 | 466 | 29891566 |
Swelling | 24.36 | 13.73 | 22 | 60424 | 35953 | 29856079 |
Hypertensive hydrocephalus | 24.21 | 13.73 | 8 | 60438 | 64 | 29891968 |
Klebsiella infection | 24.17 | 13.73 | 47 | 60399 | 6840 | 29885192 |
Gastrooesophageal reflux disease | 23.97 | 13.73 | 18 | 60428 | 32237 | 29859795 |
Blood cholesterol increased | 23.95 | 13.73 | 3 | 60443 | 16967 | 29875065 |
Contusion | 23.84 | 13.73 | 17 | 60429 | 31263 | 29860769 |
Abnormal behaviour | 23.70 | 13.73 | 11 | 60435 | 25612 | 29866420 |
Liver function test abnormal | 23.35 | 13.73 | 17 | 60429 | 30933 | 29861099 |
Wheezing | 23.34 | 13.73 | 17 | 60429 | 30921 | 29861111 |
Serotonin syndrome | 23.31 | 13.73 | 4 | 60442 | 17887 | 29874145 |
Graft versus host disease in skin | 23.29 | 13.73 | 31 | 60415 | 3276 | 29888756 |
Toxicity to various agents | 23.22 | 13.73 | 237 | 60209 | 176946 | 29715086 |
Anaplastic large-cell lymphoma | 23.10 | 13.73 | 10 | 60436 | 178 | 29891854 |
Carbamoyl phosphate synthetase deficiency | 22.97 | 13.73 | 6 | 60440 | 18 | 29892014 |
Leukoencephalopathy | 22.95 | 13.73 | 34 | 60412 | 3968 | 29888064 |
Papilloedema | 22.93 | 13.73 | 26 | 60420 | 2330 | 29889702 |
Streptococcal bacteraemia | 22.65 | 13.73 | 22 | 60424 | 1648 | 29890384 |
Dyskinesia | 22.42 | 13.73 | 8 | 60438 | 21826 | 29870206 |
Plasma cell leukaemia | 22.42 | 13.73 | 17 | 60429 | 908 | 29891124 |
Abdominal distension | 22.40 | 13.73 | 36 | 60410 | 45673 | 29846359 |
Delayed engraftment | 22.38 | 13.73 | 8 | 60438 | 83 | 29891949 |
Syncope | 22.18 | 13.73 | 92 | 60354 | 84811 | 29807221 |
BK virus infection | 22.11 | 13.73 | 35 | 60411 | 4329 | 29887703 |
Bronchitis | 21.95 | 13.73 | 28 | 60418 | 39097 | 29852935 |
Gastrointestinal mucosal disorder | 21.92 | 13.73 | 12 | 60434 | 363 | 29891669 |
Stomatitis necrotising | 21.80 | 13.73 | 8 | 60438 | 90 | 29891942 |
Gallbladder empyema | 21.64 | 13.73 | 7 | 60439 | 52 | 29891980 |
Erectile dysfunction | 21.60 | 13.73 | 5 | 60441 | 18097 | 29873935 |
Lung infiltration | 21.58 | 13.73 | 65 | 60381 | 12494 | 29879538 |
Myelopathy | 21.58 | 13.73 | 23 | 60423 | 1924 | 29890108 |
Herpes simplex | 21.52 | 13.73 | 35 | 60411 | 4429 | 29887603 |
Disturbance in attention | 21.25 | 13.73 | 9 | 60437 | 22120 | 29869912 |
Heart rate decreased | 21.04 | 13.73 | 8 | 60438 | 20986 | 29871046 |
Metastases to bone marrow | 21.02 | 13.73 | 13 | 60433 | 496 | 29891536 |
Gastrointestinal toxicity | 20.99 | 13.73 | 23 | 60423 | 1985 | 29890047 |
Visceral oedema | 20.91 | 13.73 | 5 | 60441 | 9 | 29892023 |
Respiratory arrest | 20.89 | 13.73 | 17 | 60429 | 29241 | 29862791 |
Traumatic lung injury | 20.78 | 13.73 | 18 | 60428 | 1163 | 29890869 |
Seminoma | 20.76 | 13.73 | 10 | 60436 | 230 | 29891802 |
Adrenocortical carcinoma | 20.72 | 13.73 | 6 | 60440 | 29 | 29892003 |
Osteonecrosis of jaw | 20.57 | 13.73 | 6 | 60440 | 18612 | 29873420 |
Basal cell naevus syndrome | 20.56 | 13.73 | 6 | 60440 | 30 | 29892002 |
Paternal exposure timing unspecified | 20.56 | 13.73 | 6 | 60440 | 30 | 29892002 |
Transformation to acute myeloid leukaemia | 20.54 | 13.73 | 14 | 60432 | 632 | 29891400 |
Arrhythmia | 20.47 | 13.73 | 22 | 60424 | 33147 | 29858885 |
Peripheral sensory neuropathy | 20.38 | 13.73 | 40 | 60406 | 5861 | 29886171 |
Subdural haemorrhage | 20.34 | 13.73 | 27 | 60419 | 2845 | 29889187 |
Treatment noncompliance | 20.21 | 13.73 | 13 | 60433 | 25240 | 29866792 |
Streptococcal infection | 20.15 | 13.73 | 35 | 60411 | 4673 | 29887359 |
Transient ischaemic attack | 20.14 | 13.73 | 13 | 60433 | 25187 | 29866845 |
Neuroblastoma recurrent | 20.08 | 13.73 | 7 | 60439 | 67 | 29891965 |
Mobility decreased | 19.98 | 13.73 | 14 | 60432 | 25985 | 29866047 |
Burkitt's lymphoma | 19.92 | 13.73 | 9 | 60437 | 178 | 29891854 |
Road traffic accident | 19.81 | 13.73 | 5 | 60441 | 17066 | 29874966 |
Therapy responder | 19.79 | 13.73 | 9 | 60437 | 181 | 29891851 |
Flatulence | 19.75 | 13.73 | 6 | 60440 | 18123 | 29873909 |
Head injury | 19.72 | 13.73 | 5 | 60441 | 17015 | 29875017 |
Influenza | 19.60 | 13.73 | 36 | 60410 | 43362 | 29848670 |
Staphylococcal infection | 19.59 | 13.73 | 116 | 60330 | 30108 | 29861924 |
Emotional distress | 19.53 | 13.73 | 4 | 60442 | 15761 | 29876271 |
Intestinal perforation | 19.52 | 13.73 | 49 | 60397 | 8470 | 29883562 |
Renal infarct | 19.45 | 13.73 | 17 | 60429 | 1112 | 29890920 |
Flagellate dermatitis | 19.39 | 13.73 | 5 | 60441 | 14 | 29892018 |
Atypical teratoid/rhabdoid tumour of CNS | 19.39 | 13.73 | 5 | 60441 | 14 | 29892018 |
Pneumonia cytomegaloviral | 19.37 | 13.73 | 26 | 60420 | 2770 | 29889262 |
Expanded disability status scale score increased | 19.35 | 13.73 | 9 | 60437 | 191 | 29891841 |
Myeloid leukaemia | 19.31 | 13.73 | 11 | 60435 | 360 | 29891672 |
Splenic infarction | 19.24 | 13.73 | 21 | 60425 | 1804 | 29890228 |
Enterocolitis | 19.19 | 13.73 | 42 | 60404 | 6645 | 29885387 |
Graft versus host disease in liver | 19.12 | 13.73 | 16 | 60430 | 986 | 29891046 |
Staphylococcal sepsis | 19.10 | 13.73 | 52 | 60394 | 9439 | 29882593 |
Blood culture positive | 19.04 | 13.73 | 35 | 60411 | 4884 | 29887148 |
Autoimmune neutropenia | 18.94 | 13.73 | 10 | 60436 | 281 | 29891751 |
Cerebral venous thrombosis | 18.93 | 13.73 | 13 | 60433 | 594 | 29891438 |
Wrong technique in product usage process | 18.86 | 13.73 | 21 | 60425 | 31134 | 29860898 |
Clostridium test positive | 18.85 | 13.73 | 22 | 60424 | 2034 | 29889998 |
Escherichia sepsis | 18.82 | 13.73 | 31 | 60415 | 3963 | 29888069 |
Premature ageing | 18.67 | 13.73 | 7 | 60439 | 84 | 29891948 |
Peripheral T-cell lymphoma unspecified stage III | 18.61 | 13.73 | 6 | 60440 | 44 | 29891988 |
Diverticulitis | 18.60 | 13.73 | 6 | 60440 | 17439 | 29874593 |
Metastases to meninges | 18.56 | 13.73 | 17 | 60429 | 1182 | 29890850 |
Acute myelomonocytic leukaemia | 18.45 | 13.73 | 8 | 60438 | 143 | 29891889 |
Faeces discoloured | 18.43 | 13.73 | 3 | 60443 | 13943 | 29878089 |
Dehydration | 18.41 | 13.73 | 160 | 60286 | 123379 | 29768653 |
Adverse drug reaction | 18.41 | 13.73 | 12 | 60434 | 23133 | 29868899 |
Blood pressure systolic increased | 18.37 | 13.73 | 4 | 60442 | 15106 | 29876926 |
Cerebral venous sinus thrombosis | 18.37 | 13.73 | 10 | 60436 | 299 | 29891733 |
Hyperlipidaemia | 18.36 | 13.73 | 3 | 60443 | 13904 | 29878128 |
Blindness cortical | 18.31 | 13.73 | 10 | 60436 | 301 | 29891731 |
Chromaturia | 18.29 | 13.73 | 3 | 60443 | 13862 | 29878170 |
Therapeutic product effect decreased | 18.27 | 13.73 | 19 | 60427 | 29057 | 29862975 |
Epstein-Barr viraemia | 18.26 | 13.73 | 15 | 60431 | 901 | 29891131 |
Accidental overdose | 18.26 | 13.73 | 7 | 60439 | 18268 | 29873764 |
Reticulocytosis | 18.25 | 13.73 | 10 | 60436 | 303 | 29891729 |
Refractory cytopenia with multilineage dysplasia | 18.10 | 13.73 | 8 | 60438 | 150 | 29891882 |
Arterial thrombosis | 18.09 | 13.73 | 18 | 60428 | 1388 | 29890644 |
Ischaemic cerebral infarction | 18.07 | 13.73 | 15 | 60431 | 914 | 29891118 |
Burns first degree | 18.07 | 13.73 | 4 | 60442 | 4 | 29892028 |
Dry mouth | 17.97 | 13.73 | 12 | 60434 | 22838 | 29869194 |
Vomiting | 17.92 | 13.73 | 575 | 59871 | 219243 | 29672789 |
Chemotherapy | 17.88 | 13.73 | 12 | 60434 | 528 | 29891504 |
Pneumomediastinum | 17.83 | 13.73 | 20 | 60426 | 1771 | 29890261 |
Hypokalaemia | 17.83 | 13.73 | 167 | 60279 | 50025 | 29842007 |
Pseudomonas infection | 17.77 | 13.73 | 54 | 60392 | 10428 | 29881604 |
Lethargy | 17.65 | 13.73 | 33 | 60413 | 39486 | 29852546 |
Pancreatitis | 17.63 | 13.73 | 29 | 60417 | 36461 | 29855571 |
Metastases to lymph nodes | 17.59 | 13.73 | 30 | 60416 | 3947 | 29888085 |
Gene mutation | 17.54 | 13.73 | 14 | 60432 | 807 | 29891225 |
Amnesia | 17.53 | 13.73 | 14 | 60432 | 24307 | 29867725 |
Pulmonary fibrosis | 17.51 | 13.73 | 71 | 60375 | 15819 | 29876213 |
Human herpesvirus 8 infection | 17.45 | 13.73 | 13 | 60433 | 676 | 29891356 |
Cerebral toxoplasmosis | 17.40 | 13.73 | 18 | 60428 | 1454 | 29890578 |
Metastases to spleen | 17.40 | 13.73 | 10 | 60436 | 333 | 29891699 |
Hyperbilirubinaemia | 17.34 | 13.73 | 74 | 60372 | 16868 | 29875164 |
Psychotic disorder | 17.32 | 13.73 | 11 | 60435 | 21504 | 29870528 |
Hirsutism | 17.27 | 13.73 | 8 | 60438 | 168 | 29891864 |
Adenomatous polyposis coli | 17.23 | 13.73 | 8 | 60438 | 169 | 29891863 |
Asthenia | 17.17 | 13.73 | 329 | 60117 | 220961 | 29671071 |
Autoimmune haemolytic anaemia | 17.14 | 13.73 | 30 | 60416 | 4029 | 29888003 |
Platelet transfusion | 17.13 | 13.73 | 15 | 60431 | 983 | 29891049 |
Myelitis transverse | 17.11 | 13.73 | 15 | 60431 | 985 | 29891047 |
International normalised ratio increased | 17.11 | 13.73 | 45 | 60401 | 47694 | 29844338 |
Neuroendocrine tumour of the lung metastatic | 17.08 | 13.73 | 7 | 60439 | 108 | 29891924 |
Swollen tongue | 17.08 | 13.73 | 3 | 60443 | 13189 | 29878843 |
Guillain-Barre syndrome | 17.01 | 13.73 | 34 | 60412 | 5049 | 29886983 |
Cardiomyopathy | 16.96 | 13.73 | 68 | 60378 | 15075 | 29876957 |
Neoplasm | 16.94 | 13.73 | 30 | 60416 | 4066 | 29887966 |
Laboratory test abnormal | 16.90 | 13.73 | 7 | 60439 | 17435 | 29874597 |
Infected neoplasm | 16.89 | 13.73 | 6 | 60440 | 61 | 29891971 |
Poikiloderma | 16.89 | 13.73 | 8 | 60438 | 177 | 29891855 |
Angiodysplasia | 16.82 | 13.73 | 11 | 60435 | 463 | 29891569 |
Inflammatory pseudotumour | 16.66 | 13.73 | 5 | 60441 | 28 | 29892004 |
Speech disorder | 16.58 | 13.73 | 15 | 60431 | 24497 | 29867535 |
Acanthamoeba infection | 16.55 | 13.73 | 11 | 60435 | 476 | 29891556 |
Radiation oesophagitis | 16.52 | 13.73 | 10 | 60436 | 367 | 29891665 |
Congenital hepatobiliary anomaly | 16.51 | 13.73 | 5 | 60441 | 29 | 29892003 |
Herpes simplex reactivation | 16.51 | 13.73 | 5 | 60441 | 29 | 29892003 |
Migraine | 16.51 | 13.73 | 3 | 60443 | 12871 | 29879161 |
Intentional product use issue | 16.50 | 13.73 | 128 | 60318 | 36312 | 29855720 |
Musculoskeletal pain | 16.48 | 13.73 | 23 | 60423 | 30917 | 29861115 |
Renal disorder | 16.47 | 13.73 | 14 | 60432 | 23570 | 29868462 |
Chronic myeloid leukaemia | 16.40 | 13.73 | 23 | 60423 | 2554 | 29889478 |
Ototoxicity | 16.38 | 13.73 | 17 | 60429 | 1379 | 29890653 |
Retinoblastoma | 16.37 | 13.73 | 5 | 60441 | 30 | 29892002 |
Diabetes mellitus inadequate control | 16.31 | 13.73 | 3 | 60443 | 12759 | 29879273 |
Pulmonary alveolar haemorrhage | 16.30 | 13.73 | 39 | 60407 | 6542 | 29885490 |
Ewing's sarcoma | 16.23 | 13.73 | 5 | 60441 | 31 | 29892001 |
Mucosal toxicity | 16.22 | 13.73 | 8 | 60438 | 194 | 29891838 |
Chest discomfort | 16.20 | 13.73 | 43 | 60403 | 45437 | 29846595 |
Hepatic cirrhosis | 16.20 | 13.73 | 6 | 60440 | 15993 | 29876039 |
Pneumonia fungal | 16.16 | 13.73 | 35 | 60411 | 5498 | 29886534 |
Cerebral artery occlusion | 16.14 | 13.73 | 13 | 60433 | 759 | 29891273 |
Choriocarcinoma | 15.96 | 13.73 | 5 | 60441 | 33 | 29891999 |
Product quality issue | 15.96 | 13.73 | 9 | 60437 | 18765 | 29873267 |
Neuroendocrine carcinoma | 15.95 | 13.73 | 10 | 60436 | 391 | 29891641 |
Paraparesis | 15.81 | 13.73 | 19 | 60427 | 1812 | 29890220 |
Prostate cancer | 15.80 | 13.73 | 15 | 60431 | 23942 | 29868090 |
Chronic myelomonocytic leukaemia | 15.78 | 13.73 | 12 | 60434 | 644 | 29891388 |
Rectal haemorrhage | 15.76 | 13.73 | 29 | 60417 | 34910 | 29857122 |
Iris atrophy | 15.64 | 13.73 | 6 | 60440 | 77 | 29891955 |
Nasal congestion | 15.64 | 13.73 | 9 | 60437 | 18557 | 29873475 |
Erythema ab igne | 15.62 | 13.73 | 3 | 60443 | 0 | 29892032 |
Li-Fraumeni syndrome | 15.62 | 13.73 | 3 | 60443 | 0 | 29892032 |
Decreased appetite | 15.57 | 13.73 | 211 | 60235 | 149699 | 29742333 |
Delirium | 15.57 | 13.73 | 37 | 60409 | 40594 | 29851438 |
Procalcitonin decreased | 15.57 | 13.73 | 4 | 60442 | 11 | 29892021 |
Fibrinous bronchitis | 15.57 | 13.73 | 4 | 60442 | 11 | 29892021 |
Histiocytic sarcoma | 15.57 | 13.73 | 4 | 60442 | 11 | 29892021 |
Thyroid cancer | 15.50 | 13.73 | 16 | 60430 | 1289 | 29890743 |
Clostridium colitis | 15.50 | 13.73 | 16 | 60430 | 1289 | 29890743 |
Clostridium difficile infection | 15.44 | 13.73 | 68 | 60378 | 15715 | 29876317 |
Angiocentric lymphoma | 15.41 | 13.73 | 9 | 60437 | 309 | 29891723 |
Burning sensation | 15.35 | 13.73 | 7 | 60439 | 16467 | 29875565 |
Cytomegalovirus viraemia | 15.33 | 13.73 | 35 | 60411 | 5694 | 29886338 |
Mediastinum neoplasm | 15.31 | 13.73 | 4 | 60442 | 12 | 29892020 |
Adenocarcinoma gastric | 15.30 | 13.73 | 15 | 60431 | 1136 | 29890896 |
Myoclonus | 15.25 | 13.73 | 4 | 60442 | 13308 | 29878724 |
Salivary gland cancer stage IV | 15.24 | 13.73 | 5 | 60441 | 39 | 29891993 |
Cytomegalovirus infection reactivation | 15.14 | 13.73 | 18 | 60428 | 1697 | 29890335 |
Vertigo | 15.13 | 13.73 | 14 | 60432 | 22621 | 29869411 |
Cerebral artery stenosis | 15.10 | 13.73 | 9 | 60437 | 321 | 29891711 |
Superior vena cava syndrome | 15.08 | 13.73 | 10 | 60436 | 431 | 29891601 |
Testicular germ cell cancer | 15.07 | 13.73 | 4 | 60442 | 13 | 29892019 |
Rash pruritic | 15.04 | 13.73 | 14 | 60432 | 22558 | 29869474 |
Platelet count abnormal | 14.94 | 13.73 | 21 | 60425 | 2336 | 29889696 |
Primary hypogonadism | 14.91 | 13.73 | 6 | 60440 | 88 | 29891944 |
Acute myeloid leukaemia recurrent | 14.89 | 13.73 | 17 | 60429 | 1535 | 29890497 |
Dry skin | 14.88 | 13.73 | 14 | 60432 | 22440 | 29869592 |
Oesophagitis | 14.86 | 13.73 | 53 | 60393 | 11118 | 29880914 |
Blastic plasmacytoid dendritic cell neoplasia | 14.85 | 13.73 | 6 | 60440 | 89 | 29891943 |
Electrolyte imbalance | 14.82 | 13.73 | 54 | 60392 | 11446 | 29880586 |
Blood glucose decreased | 14.81 | 13.73 | 4 | 60442 | 13049 | 29878983 |
Neutropenic infection | 14.78 | 13.73 | 14 | 60432 | 1016 | 29891016 |
Arachnoiditis | 14.78 | 13.73 | 9 | 60437 | 334 | 29891698 |
Fungal sepsis | 14.78 | 13.73 | 12 | 60434 | 709 | 29891323 |
5q minus syndrome | 14.73 | 13.73 | 7 | 60439 | 156 | 29891876 |
Pneumonia adenoviral | 14.73 | 13.73 | 7 | 60439 | 156 | 29891876 |
Non-Hodgkin's lymphoma unspecified histology aggressive | 14.72 | 13.73 | 5 | 60441 | 44 | 29891988 |
Skin exfoliation | 14.72 | 13.73 | 15 | 60431 | 23157 | 29868875 |
Hepatitis D | 14.62 | 13.73 | 5 | 60441 | 45 | 29891987 |
Bone sarcoma | 14.61 | 13.73 | 6 | 60440 | 93 | 29891939 |
Deafness | 14.61 | 13.73 | 50 | 60396 | 10275 | 29881757 |
Recall phenomenon | 14.50 | 13.73 | 11 | 60435 | 588 | 29891444 |
Lymphoma transformation | 14.49 | 13.73 | 7 | 60439 | 162 | 29891870 |
Agitation | 14.49 | 13.73 | 58 | 60388 | 54015 | 29838017 |
Mucoepidermoid carcinoma | 14.43 | 13.73 | 4 | 60442 | 16 | 29892016 |
Adenoviral hepatitis | 14.38 | 13.73 | 7 | 60439 | 165 | 29891867 |
Hepatic necrosis | 14.34 | 13.73 | 27 | 60419 | 3836 | 29888196 |
Colony stimulating factor therapy | 14.34 | 13.73 | 7 | 60439 | 166 | 29891866 |
Fungal endocarditis | 14.26 | 13.73 | 7 | 60439 | 168 | 29891864 |
Hepatic steatosis | 14.23 | 13.73 | 6 | 60440 | 14787 | 29877245 |
Meningioma | 14.17 | 13.73 | 16 | 60430 | 1427 | 29890605 |
Surgery | 14.16 | 13.73 | 3 | 60443 | 11548 | 29880484 |
Pleural effusion | 14.16 | 13.73 | 219 | 60227 | 73847 | 29818185 |
Lower respiratory tract infection | 14.09 | 13.73 | 20 | 60426 | 26694 | 29865338 |
Varicella zoster virus infection | 14.09 | 13.73 | 15 | 60431 | 1253 | 29890779 |
Ewing's sarcoma recurrent | 14.05 | 13.73 | 4 | 60442 | 18 | 29892014 |
Decorticate posture | 14.05 | 13.73 | 4 | 60442 | 18 | 29892014 |
Hypertension | 14.01 | 13.73 | 167 | 60279 | 121187 | 29770845 |
Confusional state | 13.92 | 13.73 | 190 | 60256 | 134644 | 29757388 |
Sudden death | 13.79 | 13.73 | 7 | 60439 | 15485 | 29876547 |
Source | Code | Description |
---|---|---|
ATC | L01CB01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Podophyllotoxin derivatives |
FDA MoA | N0000000176 | Topoisomerase Inhibitors |
FDA EPC | N0000175609 | Topoisomerase Inhibitor |
CHEBI has role | CHEBI:35610 | cytostatic |
CHEBI has role | CHEBI:59517 | dna synthesis inhibitors |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D000972 | Antineoplastic Agents, Phytogenic |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D059005 | Topoisomerase II Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Small cell carcinoma of lung | indication | 254632001 | DOID:5409 |
Malignant tumor of testis | indication | 363449006 | DOID:2998 |
Allogeneic bone marrow transplantation | off-label use | 58390007 | |
Ewing's sarcoma | off-label use | 76909002 | DOID:3369 |
Acute myeloid leukemia, disease | off-label use | 91861009 | |
Kaposi's sarcoma | off-label use | 109385007 | |
Diffuse non-Hodgkin's lymphoma, large cell | off-label use | 109969005 | |
Multiple myeloma | off-label use | 109989006 | DOID:9538 |
Hodgkin's disease | off-label use | 118599009 | |
Burkitt's lymphoma | off-label use | 118617000 | |
Non-small cell lung cancer | off-label use | 254637007 | DOID:3908 |
Osteosarcoma of bone | off-label use | 307576001 | DOID:3376 |
Malignant tumor of ovary | off-label use | 363443007 | DOID:2394 |
Neuroblastoma | off-label use | 432328008 | DOID:769 |
Neuroendocrine Prostate Carcinoma | off-label use | ||
Progressive Diffuse Large B-Cell Lymphoma | off-label use | ||
Testicular Germ Cell Tumor | off-label use | ||
Ovarian Germ Cell Tumor Carcinoma | off-label use | ||
Acute hemorrhage | contraindication | 8573003 | |
Fibrosis of lung | contraindication | 51615001 | DOID:3770 |
Metabolic acidosis | contraindication | 59455009 | |
Acute infectious disease | contraindication | 63171007 | |
Interstitial pneumonia | contraindication | 64667001 | |
Leukopenia | contraindication | 84828003 | DOID:615 |
Hypoalbuminemia | contraindication | 119247004 | |
Impaired renal function disorder | contraindication | 197663003 | |
Drug-induced hepatitis | contraindication | 235876009 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Breastfeeding (mother) | contraindication | 413712001 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.96 | acidic |
pKa2 | 13.08 | acidic |
pKa3 | 13.86 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase 2-alpha | Enzyme | INHIBITOR | IC50 | 7.30 | IUPHAR | CHEMBL | |||
Nuclear receptor subfamily 1 group I member 2 | Nuclear hormone receptor | WOMBAT-PK | |||||||
Canalicular multispecific organic anion transporter 2 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 6 | Transporter | WOMBAT-PK | |||||||
ATP-binding cassette sub-family G member 2 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 1 | Transporter | WOMBAT-PK | |||||||
Canalicular multispecific organic anion transporter 1 | Transporter | Km | 3.21 | WOMBAT-PK | |||||
Multidrug resistance protein 1 | Transporter | Ki | 3.28 | WOMBAT-PK | |||||
Arachidonate 15-lipoxygenase | Enzyme | IC50 | 5.50 | DRUG MATRIX |
ID | Source |
---|---|
4018141 | VUID |
N0000146478 | NUI |
D00125 | KEGG_DRUG |
4018141 | VANDF |
C0015133 | UMLSCUI |
CHEBI:4911 | CHEBI |
EVP | PDB_CHEM_ID |
CHEMBL44657 | ChEMBL_ID |
DB00773 | DRUGBANK_ID |
CHEMBL1200645 | ChEMBL_ID |
D005047 | MESH_DESCRIPTOR_UI |
36462 | PUBCHEM_CID |
6815 | IUPHAR_LIGAND_ID |
3835 | INN_ID |
6PLQ3CP4P3 | UNII |
220347 | RXNORM |
4209 | MMSL |
4709 | MMSL |
6665 | MMSL |
d00230 | MMSL |
002674 | NDDF |
387316009 | SNOMEDCT_US |
56928005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9376 | INJECTION | 20 mg | INTRAVENOUS | ANDA | 22 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9510 | INJECTION | 20 mg | INTRAVENOUS | ANDA | 22 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9511 | INJECTION | 20 mg | INTRAVENOUS | ANDA | 22 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9512 | INJECTION | 20 mg | INTRAVENOUS | ANDA | 22 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3266 | CAPSULE | 50 mg | ORAL | ANDA | 24 sections |
Toposar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5653 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | ANDA | 24 sections |
Toposar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5656 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | ANDA | 24 sections |
Toposar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5657 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | ANDA | 24 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-114 | INJECTION | 20 mg | INTRAVENOUS | ANDA | 22 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-262 | INJECTION | 20 mg | INTRAVENOUS | ANDA | 22 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-104 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | ANDA | 14 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-265 | INJECTION | 20 mg | INTRAVENOUS | ANDA | 22 sections |