Stem definition | Drug id | CAS RN |
---|---|---|
1112 | 33419-42-0 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.22 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 38 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 6.30 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 52 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.18 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.12 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5.70 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 10, 1983 | FDA | ||
March 26, 2019 | PMDA | BRISTOL-MYERS SQUIBB K.K. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 2525.89 | 15.76 | 1427 | 48779 | 96240 | 50458678 |
Neutropenia | 1074.75 | 15.76 | 1001 | 49205 | 146964 | 50407954 |
Mucosal inflammation | 858.18 | 15.76 | 520 | 49686 | 39622 | 50515296 |
Bone marrow failure | 744.40 | 15.76 | 416 | 49790 | 27208 | 50527710 |
Pancytopenia | 726.45 | 15.76 | 628 | 49578 | 83402 | 50471516 |
Thrombocytopenia | 619.76 | 15.76 | 696 | 49510 | 126977 | 50427941 |
Acute myeloid leukaemia | 597.42 | 15.76 | 294 | 49912 | 14780 | 50540138 |
Product use in unapproved indication | 539.15 | 15.76 | 618 | 49588 | 115201 | 50439717 |
Myelodysplastic syndrome | 517.17 | 15.76 | 267 | 49939 | 14865 | 50540053 |
Haematotoxicity | 414.47 | 15.76 | 187 | 50019 | 7708 | 50547210 |
Ovarian failure | 392.97 | 15.76 | 109 | 50097 | 1002 | 50553916 |
Haemophagocytic lymphohistiocytosis | 343.82 | 15.76 | 169 | 50037 | 8464 | 50546454 |
Off label use | 342.75 | 15.76 | 1139 | 49067 | 473287 | 50081631 |
Disease progression | 341.09 | 15.76 | 447 | 49759 | 95419 | 50459499 |
Sepsis | 328.19 | 15.76 | 521 | 49685 | 132404 | 50422514 |
Myelosuppression | 311.58 | 15.76 | 184 | 50022 | 13333 | 50541585 |
Second primary malignancy | 307.52 | 15.76 | 146 | 50060 | 6768 | 50548150 |
Neutropenic sepsis | 303.82 | 15.76 | 184 | 50022 | 13963 | 50540955 |
Febrile bone marrow aplasia | 279.87 | 15.76 | 133 | 50073 | 6178 | 50548740 |
Multiple organ dysfunction syndrome | 272.41 | 15.76 | 291 | 49915 | 50046 | 50504872 |
Pain | 265.39 | 15.76 | 122 | 50084 | 578781 | 49976137 |
Venoocclusive liver disease | 256.08 | 15.76 | 111 | 50095 | 4150 | 50550768 |
Septic shock | 250.34 | 15.76 | 296 | 49910 | 56879 | 50498039 |
Tumour lysis syndrome | 245.03 | 15.76 | 128 | 50078 | 7293 | 50547625 |
Posterior reversible encephalopathy syndrome | 233.42 | 15.76 | 159 | 50047 | 14769 | 50540149 |
Malignant neoplasm progression | 233.42 | 15.76 | 312 | 49894 | 67812 | 50487106 |
Neutrophil count decreased | 231.42 | 15.76 | 256 | 49950 | 45770 | 50509148 |
Aplasia | 221.56 | 15.76 | 97 | 50109 | 3716 | 50551202 |
Arthralgia | 219.30 | 15.76 | 81 | 50125 | 438621 | 50116297 |
Joint swelling | 215.70 | 15.76 | 6 | 50200 | 245280 | 50309638 |
Diffuse large B-cell lymphoma refractory | 200.87 | 15.76 | 64 | 50142 | 982 | 50553936 |
Pyrexia | 197.50 | 15.76 | 822 | 49384 | 379381 | 50175537 |
Encephalopathy | 182.51 | 15.76 | 195 | 50011 | 33516 | 50521402 |
Anaemia | 178.51 | 15.76 | 603 | 49603 | 251853 | 50303065 |
Maternal exposure before pregnancy | 177.56 | 15.76 | 94 | 50112 | 5503 | 50549415 |
Peripheral swelling | 167.59 | 15.76 | 9 | 50197 | 205927 | 50348991 |
Platelet count decreased | 162.29 | 15.76 | 328 | 49878 | 100398 | 50454520 |
Nasopharyngitis | 161.59 | 15.76 | 7 | 50199 | 192920 | 50361998 |
Stem cell transplant | 160.73 | 15.76 | 61 | 50145 | 1607 | 50553311 |
Leukopenia | 153.19 | 15.76 | 255 | 49951 | 67273 | 50487645 |
Abdominal discomfort | 152.02 | 15.76 | 24 | 50182 | 231617 | 50323301 |
Drug resistance | 149.83 | 15.76 | 135 | 50071 | 18854 | 50536064 |
Diffuse large B-cell lymphoma recurrent | 148.91 | 15.76 | 57 | 50149 | 1538 | 50553380 |
Ototoxicity | 148.80 | 15.76 | 52 | 50154 | 1075 | 50553843 |
Disease recurrence | 147.21 | 15.76 | 137 | 50069 | 19944 | 50534974 |
Venoocclusive disease | 146.21 | 15.76 | 59 | 50147 | 1837 | 50553081 |
Drug hypersensitivity | 145.81 | 15.76 | 35 | 50171 | 250975 | 50303943 |
Product dose omission issue | 138.02 | 15.76 | 12 | 50194 | 183826 | 50371092 |
Fall | 133.39 | 15.76 | 84 | 50122 | 334848 | 50220070 |
Teratoma | 132.05 | 15.76 | 30 | 50176 | 107 | 50554811 |
Cytomegalovirus infection | 130.62 | 15.76 | 122 | 50084 | 17840 | 50537078 |
Contraindicated product administered | 129.55 | 15.76 | 4 | 50202 | 148954 | 50405964 |
Neutropenic colitis | 129.21 | 15.76 | 58 | 50148 | 2359 | 50552559 |
Systemic lupus erythematosus | 125.18 | 15.76 | 3 | 50203 | 140619 | 50414299 |
Pruritus | 123.04 | 15.76 | 64 | 50142 | 283504 | 50271414 |
Bacteraemia | 122.61 | 15.76 | 107 | 50099 | 14326 | 50540592 |
Aspergillus infection | 121.95 | 15.76 | 79 | 50127 | 6742 | 50548176 |
Ovarian germ cell teratoma | 119.53 | 15.76 | 25 | 50181 | 53 | 50554865 |
Weight increased | 117.50 | 15.76 | 28 | 50178 | 201863 | 50353055 |
Hepatosplenic T-cell lymphoma | 117.14 | 15.76 | 37 | 50169 | 551 | 50554367 |
Arthropathy | 116.65 | 15.76 | 11 | 50195 | 157895 | 50397023 |
Rash | 115.11 | 15.76 | 160 | 50046 | 437311 | 50117607 |
Headache | 111.04 | 15.76 | 209 | 49997 | 506326 | 50048592 |
Cardiotoxicity | 110.19 | 15.76 | 75 | 50131 | 6952 | 50547966 |
Fatigue | 109.66 | 15.76 | 350 | 49856 | 707251 | 49847667 |
Malignant transformation | 108.08 | 15.76 | 31 | 50175 | 325 | 50554593 |
Pulmonary haemorrhage | 105.88 | 15.76 | 71 | 50135 | 6421 | 50548497 |
Insomnia | 104.24 | 15.76 | 23 | 50183 | 174842 | 50380076 |
Musculoskeletal stiffness | 103.28 | 15.76 | 6 | 50200 | 128475 | 50426443 |
Oesophagitis | 101.37 | 15.76 | 93 | 50113 | 13290 | 50541628 |
Neoplasm progression | 100.47 | 15.76 | 134 | 50072 | 29023 | 50525895 |
Swelling | 100.25 | 15.76 | 37 | 50169 | 200835 | 50354083 |
Pain in extremity | 99.83 | 15.76 | 75 | 50131 | 272790 | 50282128 |
Malaise | 97.20 | 15.76 | 114 | 50092 | 335418 | 50219500 |
Cytopenia | 95.26 | 15.76 | 75 | 50131 | 8700 | 50546218 |
Graft versus host disease | 94.76 | 15.76 | 65 | 50141 | 6101 | 50548817 |
Drug intolerance | 94.18 | 15.76 | 50 | 50156 | 219054 | 50335864 |
Candida infection | 91.83 | 15.76 | 115 | 50091 | 23408 | 50531510 |
Glossodynia | 91.07 | 15.76 | 6 | 50200 | 115563 | 50439355 |
Primary hypogonadism | 90.23 | 15.76 | 23 | 50183 | 147 | 50554771 |
Alveolar soft part sarcoma | 90.15 | 15.76 | 21 | 50185 | 86 | 50554832 |
Bronchopulmonary aspergillosis | 89.19 | 15.76 | 68 | 50138 | 7524 | 50547394 |
Injection site pain | 86.80 | 15.76 | 6 | 50200 | 111018 | 50443900 |
Acute graft versus host disease | 86.29 | 15.76 | 52 | 50154 | 3906 | 50551012 |
Enterococcal infection | 85.95 | 15.76 | 64 | 50142 | 6834 | 50548084 |
Hypokalaemia | 85.23 | 15.76 | 235 | 49971 | 87757 | 50467161 |
Neurotoxicity | 84.61 | 15.76 | 88 | 50118 | 14652 | 50540266 |
Premature menopause | 83.80 | 15.76 | 31 | 50175 | 759 | 50554159 |
Dizziness | 82.94 | 15.76 | 135 | 50071 | 346234 | 50208684 |
Therapeutic product effect decreased | 82.89 | 15.76 | 17 | 50189 | 136033 | 50418885 |
Colitis | 81.37 | 15.76 | 141 | 50065 | 38388 | 50516530 |
Osteosarcoma | 81.16 | 15.76 | 20 | 50186 | 109 | 50554809 |
Cystitis haemorrhagic | 79.06 | 15.76 | 48 | 50158 | 3654 | 50551264 |
Hypersensitivity | 78.83 | 15.76 | 59 | 50147 | 215102 | 50339816 |
Clostridium difficile colitis | 77.80 | 15.76 | 92 | 50114 | 17650 | 50537268 |
Fungaemia | 75.97 | 15.76 | 38 | 50168 | 1974 | 50552944 |
Anxiety | 75.61 | 15.76 | 41 | 50165 | 177565 | 50377353 |
Urticaria | 75.28 | 15.76 | 18 | 50188 | 129543 | 50425375 |
Human herpesvirus 6 infection | 74.91 | 15.76 | 41 | 50165 | 2565 | 50552353 |
Hepatitis B reactivation | 74.66 | 15.76 | 38 | 50168 | 2049 | 50552869 |
Cervix disorder | 74.60 | 15.76 | 25 | 50181 | 453 | 50554465 |
Discomfort | 73.87 | 15.76 | 10 | 50196 | 108370 | 50446548 |
Asthma | 72.31 | 15.76 | 4 | 50202 | 89333 | 50465585 |
Leukoencephalopathy | 71.95 | 15.76 | 46 | 50160 | 3837 | 50551081 |
Nephropathy toxic | 71.17 | 15.76 | 61 | 50145 | 7968 | 50546950 |
Cytomegalovirus viraemia | 70.85 | 15.76 | 49 | 50157 | 4660 | 50550258 |
Teratoma benign | 70.44 | 15.76 | 16 | 50190 | 57 | 50554861 |
Thrombotic microangiopathy | 70.32 | 15.76 | 63 | 50143 | 8728 | 50546190 |
Muscle spasms | 69.95 | 15.76 | 19 | 50187 | 125534 | 50429384 |
Enterobacter infection | 69.36 | 15.76 | 35 | 50171 | 1853 | 50553065 |
Respiratory failure | 68.84 | 15.76 | 223 | 49983 | 90958 | 50463960 |
Complications of bone marrow transplant | 67.33 | 15.76 | 23 | 50183 | 443 | 50554475 |
Disseminated intravascular coagulation | 67.24 | 15.76 | 84 | 50122 | 17051 | 50537867 |
White blood cell count decreased | 67.11 | 15.76 | 261 | 49945 | 116461 | 50438457 |
Feeling abnormal | 66.23 | 15.76 | 21 | 50185 | 125471 | 50429447 |
Acute lymphocytic leukaemia recurrent | 65.00 | 15.76 | 34 | 50172 | 1941 | 50552977 |
Renal salt-wasting syndrome | 62.88 | 15.76 | 19 | 50187 | 242 | 50554676 |
Capillary leak syndrome | 60.67 | 15.76 | 32 | 50174 | 1858 | 50553060 |
Lymphopenia | 60.38 | 15.76 | 76 | 50130 | 15545 | 50539373 |
Hypomagnesaemia | 60.06 | 15.76 | 93 | 50113 | 23063 | 50531855 |
Human bocavirus infection | 60.01 | 15.76 | 20 | 50186 | 356 | 50554562 |
Acute promyelocytic leukaemia | 59.64 | 15.76 | 25 | 50181 | 859 | 50554059 |
Overdose | 59.63 | 15.76 | 13 | 50193 | 99714 | 50455204 |
Bronchitis | 59.47 | 15.76 | 15 | 50191 | 104144 | 50450774 |
Klebsiella infection | 58.43 | 15.76 | 52 | 50154 | 7142 | 50547776 |
BK virus infection | 58.07 | 15.76 | 36 | 50170 | 2845 | 50552073 |
Sinusitis | 57.19 | 15.76 | 51 | 50155 | 170507 | 50384411 |
Gene mutation | 56.99 | 15.76 | 27 | 50179 | 1244 | 50553674 |
Graft versus host disease in skin | 56.80 | 15.76 | 34 | 50172 | 2522 | 50552396 |
Systemic candida | 56.58 | 15.76 | 35 | 50171 | 2755 | 50552163 |
JC virus infection | 56.20 | 15.76 | 30 | 50176 | 1785 | 50553133 |
Skin candida | 55.91 | 15.76 | 27 | 50179 | 1299 | 50553619 |
Contusion | 55.36 | 15.76 | 21 | 50185 | 112162 | 50442756 |
Hospitalisation | 55.11 | 15.76 | 3 | 50203 | 67934 | 50486984 |
Large intestinal ulcer perforation | 53.86 | 15.76 | 13 | 50193 | 64 | 50554854 |
Injection site erythema | 53.29 | 15.76 | 6 | 50200 | 74930 | 50479988 |
Post transplant lymphoproliferative disorder | 52.37 | 15.76 | 39 | 50167 | 4165 | 50550753 |
Acute respiratory distress syndrome | 52.31 | 15.76 | 83 | 50123 | 21016 | 50533902 |
Therapy partial responder | 52.26 | 15.76 | 47 | 50159 | 6544 | 50548374 |
Epstein-Barr virus infection | 51.77 | 15.76 | 48 | 50158 | 6949 | 50547969 |
Acute myeloid leukaemia recurrent | 51.74 | 15.76 | 26 | 50180 | 1364 | 50553554 |
Progressive multifocal leukoencephalopathy | 51.21 | 15.76 | 60 | 50146 | 11397 | 50543521 |
Deafness | 50.83 | 15.76 | 70 | 50136 | 15621 | 50539297 |
Herpes simplex | 50.82 | 15.76 | 48 | 50158 | 7114 | 50547804 |
Blood pressure increased | 50.69 | 15.76 | 35 | 50171 | 133097 | 50421821 |
Myeloid leukaemia | 50.58 | 15.76 | 17 | 50189 | 311 | 50554607 |
Mucormycosis | 49.98 | 15.76 | 31 | 50175 | 2452 | 50552466 |
Neuropathy peripheral | 49.73 | 15.76 | 209 | 49997 | 96548 | 50458370 |
Aplastic anaemia | 49.71 | 15.76 | 49 | 50157 | 7654 | 50547264 |
Secondary immunodeficiency | 49.51 | 15.76 | 24 | 50182 | 1164 | 50553754 |
Migraine | 48.86 | 15.76 | 8 | 50198 | 75272 | 50479646 |
Impaired healing | 48.60 | 15.76 | 6 | 50200 | 69780 | 50485138 |
Pleural effusion | 48.32 | 15.76 | 184 | 50022 | 81270 | 50473648 |
Staphylococcal bacteraemia | 47.24 | 15.76 | 39 | 50167 | 4838 | 50550080 |
Superior vena cava syndrome | 47.10 | 15.76 | 19 | 50187 | 591 | 50554327 |
Loss of personal independence in daily activities | 46.47 | 15.76 | 7 | 50199 | 70043 | 50484875 |
Ascites | 46.45 | 15.76 | 107 | 50099 | 35754 | 50519164 |
Peripheral sensory neuropathy | 46.44 | 15.76 | 44 | 50162 | 6547 | 50548371 |
Klebsiella sepsis | 46.43 | 15.76 | 23 | 50183 | 1170 | 50553748 |
Neoplasm recurrence | 46.23 | 15.76 | 29 | 50177 | 2340 | 50552578 |
Hepatic enzyme increased | 46.14 | 15.76 | 41 | 50165 | 137339 | 50417579 |
Encephalitis viral | 45.56 | 15.76 | 25 | 50181 | 1572 | 50553346 |
Pericarditis | 45.56 | 15.76 | 11 | 50195 | 78678 | 50476240 |
Arthritis | 44.89 | 15.76 | 15 | 50191 | 86706 | 50468212 |
Leukaemia | 44.79 | 15.76 | 33 | 50173 | 3466 | 50551452 |
Staphylococcal infection | 44.74 | 15.76 | 105 | 50101 | 35511 | 50519407 |
Acute graft versus host disease in skin | 44.46 | 15.76 | 31 | 50175 | 2987 | 50551931 |
Epstein-Barr virus associated lymphoproliferative disorder | 44.25 | 15.76 | 25 | 50181 | 1664 | 50553254 |
Memory impairment | 44.20 | 15.76 | 12 | 50194 | 79348 | 50475570 |
Amenorrhoea | 44.00 | 15.76 | 48 | 50158 | 8436 | 50546482 |
Suicidal ideation | 43.25 | 15.76 | 3 | 50203 | 55382 | 50499536 |
Refractory anaemia with an excess of blasts | 43.20 | 15.76 | 16 | 50190 | 393 | 50554525 |
Renal tubular disorder | 43.01 | 15.76 | 28 | 50178 | 2409 | 50552509 |
Blood culture positive | 42.88 | 15.76 | 35 | 50171 | 4273 | 50550645 |
Pneumonia fungal | 42.80 | 15.76 | 35 | 50171 | 4285 | 50550633 |
Acute lymphocytic leukaemia | 42.64 | 15.76 | 27 | 50179 | 2214 | 50552704 |
Unmasking of previously unidentified disease | 42.64 | 15.76 | 19 | 50187 | 759 | 50554159 |
Influenza like illness | 42.41 | 15.76 | 4 | 50202 | 57455 | 50497463 |
Streptococcal bacteraemia | 42.08 | 15.76 | 23 | 50183 | 1435 | 50553483 |
Mesenteric abscess | 41.68 | 15.76 | 11 | 50195 | 82 | 50554836 |
Inappropriate schedule of product administration | 41.66 | 15.76 | 10 | 50196 | 71821 | 50483097 |
Cutaneous calcification | 41.11 | 15.76 | 11 | 50195 | 87 | 50554831 |
Congestive cardiomyopathy | 41.11 | 15.76 | 38 | 50168 | 5480 | 50549438 |
Adenovirus infection | 40.83 | 15.76 | 30 | 50176 | 3138 | 50551780 |
Bacterial infection | 40.29 | 15.76 | 64 | 50142 | 16217 | 50538701 |
Diffuse large B-cell lymphoma | 40.27 | 15.76 | 38 | 50168 | 5624 | 50549294 |
Gait disturbance | 40.17 | 15.76 | 54 | 50152 | 149951 | 50404967 |
Varicella zoster virus infection | 40.06 | 15.76 | 27 | 50179 | 2462 | 50552456 |
Sweat gland tumour | 40.05 | 15.76 | 11 | 50195 | 97 | 50554821 |
Leukaemia recurrent | 39.60 | 15.76 | 21 | 50185 | 1233 | 50553685 |
Medulloblastoma recurrent | 39.49 | 15.76 | 10 | 50196 | 62 | 50554856 |
Encephalitis cytomegalovirus | 38.83 | 15.76 | 16 | 50190 | 526 | 50554392 |
Abdominal compartment syndrome | 38.71 | 15.76 | 16 | 50190 | 530 | 50554388 |
Pneumothorax | 38.70 | 15.76 | 58 | 50148 | 13976 | 50540942 |
Respiratory distress | 38.42 | 15.76 | 90 | 50116 | 30399 | 50524519 |
Oedema peripheral | 38.25 | 15.76 | 61 | 50145 | 157900 | 50397018 |
Nail pigmentation | 38.16 | 15.76 | 12 | 50194 | 176 | 50554742 |
Recurrent cancer | 38.08 | 15.76 | 23 | 50183 | 1734 | 50553184 |
Clostridium bacteraemia | 37.97 | 15.76 | 12 | 50194 | 179 | 50554739 |
Weight decreased | 37.95 | 15.76 | 104 | 50102 | 221141 | 50333777 |
Gastrointestinal fungal infection | 37.83 | 15.76 | 13 | 50193 | 255 | 50554663 |
Fungal oesophagitis | 37.73 | 15.76 | 16 | 50190 | 566 | 50554352 |
Blister | 37.38 | 15.76 | 19 | 50187 | 85399 | 50469519 |
Abdominal pain upper | 37.20 | 15.76 | 63 | 50143 | 159246 | 50395672 |
Listeria sepsis | 37.13 | 15.76 | 16 | 50190 | 589 | 50554329 |
Incorrect dose administered | 36.73 | 15.76 | 3 | 50203 | 48411 | 50506507 |
Pneumatosis intestinalis | 36.71 | 15.76 | 24 | 50182 | 2079 | 50552839 |
Nasal abscess | 36.70 | 15.76 | 11 | 50195 | 136 | 50554782 |
Stress | 36.55 | 15.76 | 5 | 50201 | 53788 | 50501130 |
Pulmonary alveolar haemorrhage | 36.52 | 15.76 | 31 | 50175 | 3996 | 50550922 |
Enterococcal sepsis | 36.48 | 15.76 | 20 | 50186 | 1255 | 50553663 |
Musculoskeletal pain | 36.46 | 15.76 | 13 | 50193 | 72164 | 50482754 |
T-cell lymphoma | 36.41 | 15.76 | 16 | 50190 | 618 | 50554300 |
Alopecia | 35.77 | 15.76 | 124 | 50082 | 244923 | 50309995 |
Blood cholesterol increased | 35.53 | 15.76 | 6 | 50200 | 55209 | 50499709 |
Mucocutaneous ulceration | 35.38 | 15.76 | 11 | 50195 | 155 | 50554763 |
Leukoerythroblastosis | 35.38 | 15.76 | 12 | 50194 | 226 | 50554692 |
Acquired gene mutation | 35.27 | 15.76 | 17 | 50189 | 814 | 50554104 |
Therapy non-responder | 35.12 | 15.76 | 121 | 50085 | 50901 | 50504017 |
Staphylococcal sepsis | 35.09 | 15.76 | 39 | 50167 | 6997 | 50547921 |
Condition aggravated | 34.76 | 15.76 | 164 | 50042 | 296894 | 50258024 |
Escherichia bacteraemia | 34.61 | 15.76 | 27 | 50179 | 3089 | 50551829 |
Palpitations | 34.46 | 15.76 | 26 | 50180 | 94480 | 50460438 |
Gastrointestinal toxicity | 34.44 | 15.76 | 32 | 50174 | 4645 | 50550273 |
Splenomegaly | 34.19 | 15.76 | 45 | 50161 | 9615 | 50545303 |
Necrotising gastritis | 34.12 | 15.76 | 9 | 50197 | 67 | 50554851 |
Venous thrombosis | 33.75 | 15.76 | 31 | 50175 | 4435 | 50550483 |
Klebsiella bacteraemia | 33.72 | 15.76 | 19 | 50187 | 1258 | 50553660 |
Adverse drug reaction | 33.41 | 15.76 | 7 | 50199 | 55215 | 50499703 |
Cardiomyopathy acute | 33.31 | 15.76 | 11 | 50195 | 190 | 50554728 |
Hair follicle tumour benign | 33.17 | 15.76 | 13 | 50193 | 374 | 50554544 |
Bacterial sepsis | 33.15 | 15.76 | 28 | 50178 | 3584 | 50551334 |
Gastroenteritis norovirus | 33.12 | 15.76 | 21 | 50185 | 1726 | 50553192 |
Epstein Barr virus positive mucocutaneous ulcer | 32.92 | 15.76 | 13 | 50193 | 382 | 50554536 |
Chloroma | 32.79 | 15.76 | 11 | 50195 | 200 | 50554718 |
Bone marrow transplant | 32.76 | 15.76 | 15 | 50191 | 639 | 50554279 |
Hypogammaglobulinaemia | 32.66 | 15.76 | 34 | 50172 | 5665 | 50549253 |
Oesophageal candidiasis | 32.66 | 15.76 | 32 | 50174 | 4962 | 50549956 |
Blood glucose increased | 32.52 | 15.76 | 15 | 50191 | 71309 | 50483609 |
Basal ganglion degeneration | 32.51 | 15.76 | 13 | 50193 | 395 | 50554523 |
Hepatosplenomegaly | 32.32 | 15.76 | 23 | 50183 | 2289 | 50552629 |
Dry mouth | 32.23 | 15.76 | 8 | 50198 | 56170 | 50498748 |
Injury | 32.19 | 15.76 | 5 | 50201 | 48920 | 50505998 |
Hepatitis B | 32.09 | 15.76 | 27 | 50179 | 3439 | 50551479 |
Tumour hyperprogression | 32.03 | 15.76 | 9 | 50197 | 87 | 50554831 |
Sinus polyp | 31.98 | 15.76 | 12 | 50194 | 306 | 50554612 |
T-cell type acute leukaemia | 31.96 | 15.76 | 8 | 50198 | 47 | 50554871 |
Peripheral motor neuropathy | 31.71 | 15.76 | 19 | 50187 | 1412 | 50553506 |
Tumour necrosis | 31.11 | 15.76 | 15 | 50191 | 719 | 50554199 |
Tonsillar haemorrhage | 31.09 | 15.76 | 11 | 50195 | 236 | 50554682 |
Subdural hygroma | 31.05 | 15.76 | 11 | 50195 | 237 | 50554681 |
Injection site reaction | 30.98 | 15.76 | 6 | 50200 | 50026 | 50504892 |
Ill-defined disorder | 30.94 | 15.76 | 8 | 50198 | 54646 | 50500272 |
Myocardial infarction | 30.57 | 15.76 | 26 | 50180 | 89001 | 50465917 |
White blood cell count abnormal | 30.36 | 15.76 | 32 | 50174 | 5408 | 50549510 |
Cytokine release syndrome | 30.22 | 15.76 | 40 | 50166 | 8594 | 50546324 |
Metastases to diaphragm | 29.79 | 15.76 | 7 | 50199 | 30 | 50554888 |
Rhinovirus infection | 29.60 | 15.76 | 26 | 50180 | 3508 | 50551410 |
Pseudomonal sepsis | 29.55 | 15.76 | 21 | 50185 | 2086 | 50552832 |
Renal failure | 29.51 | 15.76 | 194 | 50012 | 106439 | 50448479 |
Vision blurred | 29.50 | 15.76 | 21 | 50185 | 78626 | 50476292 |
Injection site pruritus | 29.33 | 15.76 | 3 | 50203 | 40408 | 50514510 |
Tissue infiltration | 28.70 | 15.76 | 13 | 50193 | 540 | 50554378 |
Urinary tract infection | 28.40 | 15.76 | 120 | 50086 | 223900 | 50331018 |
Cytomegalovirus chorioretinitis | 28.29 | 15.76 | 18 | 50188 | 1489 | 50553429 |
Depression | 28.17 | 15.76 | 78 | 50128 | 165345 | 50389573 |
Epiphyses premature fusion | 28.13 | 15.76 | 7 | 50199 | 40 | 50554878 |
Device related infection | 28.10 | 15.76 | 63 | 50143 | 20672 | 50534246 |
Nasal congestion | 27.96 | 15.76 | 8 | 50198 | 51112 | 50503806 |
Chronic graft versus host disease | 27.92 | 15.76 | 23 | 50183 | 2844 | 50552074 |
Gastrooesophageal reflux disease | 27.89 | 15.76 | 21 | 50185 | 76407 | 50478511 |
Drug clearance increased | 27.88 | 15.76 | 8 | 50198 | 84 | 50554834 |
Ocular vascular disorder | 27.80 | 15.76 | 11 | 50195 | 325 | 50554593 |
Sinoatrial block | 27.40 | 15.76 | 14 | 50192 | 761 | 50554157 |
Thymus enlargement | 27.22 | 15.76 | 8 | 50198 | 92 | 50554826 |
Trichosporon infection | 27.22 | 15.76 | 10 | 50196 | 240 | 50554678 |
Bacterial tracheitis | 27.20 | 15.76 | 6 | 50200 | 18 | 50554900 |
International normalised ratio increased | 27.09 | 15.76 | 5 | 50201 | 43147 | 50511771 |
Parainfluenzae virus infection | 27.01 | 15.76 | 19 | 50187 | 1856 | 50553062 |
Fungal infection | 26.99 | 15.76 | 78 | 50128 | 29887 | 50525031 |
Delayed puberty | 26.99 | 15.76 | 8 | 50198 | 95 | 50554823 |
Enteritis | 26.98 | 15.76 | 34 | 50172 | 6961 | 50547957 |
Femur fracture | 26.63 | 15.76 | 3 | 50203 | 37461 | 50517457 |
Acute myelomonocytic leukaemia | 26.56 | 15.76 | 9 | 50197 | 169 | 50554749 |
Cardiomyopathy | 26.54 | 15.76 | 52 | 50154 | 15534 | 50539384 |
Toxic encephalopathy | 26.53 | 15.76 | 30 | 50176 | 5485 | 50549433 |
Plasma cell leukaemia | 26.53 | 15.76 | 15 | 50191 | 1000 | 50553918 |
Retinal pigment epitheliopathy | 26.36 | 15.76 | 9 | 50197 | 173 | 50554745 |
Vomiting | 26.35 | 15.76 | 620 | 49586 | 460138 | 50094780 |
Hyperhidrosis | 26.23 | 15.76 | 30 | 50176 | 89396 | 50465522 |
Acute kidney injury | 26.10 | 15.76 | 343 | 49863 | 227715 | 50327203 |
Metastases to central nervous system | 26.08 | 15.76 | 43 | 50163 | 11239 | 50543679 |
Neck pain | 26.02 | 15.76 | 12 | 50194 | 57055 | 50497863 |
Urinary tract infection bacterial | 25.99 | 15.76 | 26 | 50180 | 4133 | 50550785 |
Ejection fraction decreased | 25.92 | 15.76 | 57 | 50149 | 18463 | 50536455 |
Folliculitis | 25.83 | 15.76 | 4 | 50202 | 39221 | 50515697 |
Clostridium colitis | 25.82 | 15.76 | 18 | 50188 | 1734 | 50553184 |
Lower respiratory tract infection | 25.75 | 15.76 | 34 | 50172 | 95167 | 50459751 |
Paraneoplastic neurological syndrome | 25.65 | 15.76 | 5 | 50201 | 6 | 50554912 |
Atypical haemolytic uraemic syndrome | 25.49 | 15.76 | 12 | 50194 | 545 | 50554373 |
Metastases to lung | 25.47 | 15.76 | 42 | 50164 | 10978 | 50543940 |
Enterocolitis | 25.45 | 15.76 | 32 | 50174 | 6535 | 50548383 |
Metastases to lymph nodes | 25.29 | 15.76 | 33 | 50173 | 6991 | 50547927 |
Vertigo | 25.07 | 15.76 | 10 | 50196 | 51822 | 50503096 |
Burning sensation | 25.06 | 15.76 | 7 | 50199 | 45439 | 50509479 |
Respiratory syncytial virus infection | 24.96 | 15.76 | 28 | 50178 | 5074 | 50549844 |
Respiratory symptom | 24.85 | 15.76 | 20 | 50186 | 2394 | 50552524 |
Listeriosis | 24.83 | 15.76 | 16 | 50190 | 1352 | 50553566 |
Back pain | 24.83 | 15.76 | 123 | 50083 | 219907 | 50335011 |
Pseudomonas infection | 24.63 | 15.76 | 38 | 50168 | 9392 | 50545526 |
Spinal cord paralysis | 24.62 | 15.76 | 6 | 50200 | 31 | 50554887 |
Cardiac failure | 24.58 | 15.76 | 144 | 50062 | 75896 | 50479022 |
Cerebellar haemangioma | 24.52 | 15.76 | 7 | 50199 | 72 | 50554846 |
Hypothyroidism | 24.42 | 15.76 | 82 | 50124 | 34043 | 50520875 |
Mobility decreased | 24.35 | 15.76 | 26 | 50180 | 79922 | 50474996 |
Myeloproliferative neoplasm | 24.33 | 15.76 | 11 | 50195 | 455 | 50554463 |
Cytomegalovirus colitis | 24.28 | 15.76 | 18 | 50188 | 1909 | 50553009 |
Somnolence | 24.27 | 15.76 | 76 | 50130 | 154909 | 50400009 |
Myalgia | 23.97 | 15.76 | 55 | 50151 | 124264 | 50430654 |
Retinoblastoma | 23.94 | 15.76 | 7 | 50199 | 79 | 50554839 |
Cytogenetic abnormality | 23.82 | 15.76 | 11 | 50195 | 478 | 50554440 |
Unevaluable event | 23.78 | 15.76 | 8 | 50198 | 46058 | 50508860 |
Drug abuse | 23.76 | 15.76 | 15 | 50191 | 59831 | 50495087 |
Vena cava thrombosis | 23.51 | 15.76 | 18 | 50188 | 2003 | 50552915 |
Depressed mood | 23.50 | 15.76 | 3 | 50203 | 34020 | 50520898 |
Pericardial effusion | 23.42 | 15.76 | 67 | 50139 | 25522 | 50529396 |
Mouth ulceration | 23.39 | 15.76 | 71 | 50135 | 27953 | 50526965 |
Wrong technique in product usage process | 23.32 | 15.76 | 13 | 50193 | 55497 | 50499421 |
Uterine enlargement | 23.22 | 15.76 | 14 | 50192 | 1052 | 50553866 |
Chronic obstructive pulmonary disease | 23.20 | 15.76 | 12 | 50194 | 53423 | 50501495 |
Toxic neuropathy | 23.11 | 15.76 | 10 | 50196 | 372 | 50554546 |
Pulmonary toxicity | 23 | 15.76 | 28 | 50178 | 5534 | 50549384 |
Hypoxia | 22.89 | 15.76 | 106 | 50100 | 51017 | 50503901 |
Radiation pneumonitis | 22.73 | 15.76 | 15 | 50191 | 1320 | 50553598 |
Tachycardia | 22.64 | 15.76 | 173 | 50033 | 99590 | 50455328 |
Respiratory tract infection fungal | 22.62 | 15.76 | 10 | 50196 | 392 | 50554526 |
Dyspnoea | 22.60 | 15.76 | 395 | 49811 | 547213 | 50007705 |
B-cell lymphoma recurrent | 22.59 | 15.76 | 10 | 50196 | 393 | 50554525 |
Hepatic failure | 22.59 | 15.76 | 77 | 50129 | 32206 | 50522712 |
Cytokine storm | 22.58 | 15.76 | 9 | 50197 | 271 | 50554647 |
Metastases to bone marrow | 22.46 | 15.76 | 9 | 50197 | 275 | 50554643 |
Neutrophil count abnormal | 22.44 | 15.76 | 19 | 50187 | 2440 | 50552478 |
Hypophosphataemia | 22.10 | 15.76 | 34 | 50172 | 8380 | 50546538 |
Abortion spontaneous | 22.01 | 15.76 | 7 | 50199 | 41765 | 50513153 |
Stenotrophomonas infection | 21.95 | 15.76 | 16 | 50190 | 1653 | 50553265 |
Suicide attempt | 21.90 | 15.76 | 12 | 50194 | 51720 | 50503198 |
Hypoglycaemia | 21.87 | 15.76 | 13 | 50193 | 53568 | 50501350 |
Iris atrophy | 21.74 | 15.76 | 6 | 50200 | 54 | 50554864 |
Vulvovaginal inflammation | 21.65 | 15.76 | 11 | 50195 | 591 | 50554327 |
Streptococcal sepsis | 21.63 | 15.76 | 16 | 50190 | 1691 | 50553227 |
Genotoxicity | 21.56 | 15.76 | 5 | 50201 | 20 | 50554898 |
Vulvovaginitis | 21.56 | 15.76 | 9 | 50197 | 306 | 50554612 |
Follicular thyroid cancer | 21.54 | 15.76 | 6 | 50200 | 56 | 50554862 |
Paranasal sinus mucosal hypertrophy | 21.36 | 15.76 | 5 | 50201 | 21 | 50554897 |
Hepatic lesion | 21.35 | 15.76 | 23 | 50183 | 3985 | 50550933 |
Serum ferritin increased | 21.21 | 15.76 | 26 | 50180 | 5176 | 50549742 |
Metastases to spleen | 21.19 | 15.76 | 7 | 50199 | 121 | 50554797 |
Renal impairment | 21.13 | 15.76 | 138 | 50068 | 75523 | 50479395 |
Retroperitoneal abscess | 20.83 | 15.76 | 7 | 50199 | 128 | 50554790 |
Primary mediastinal large B-cell lymphoma recurrent | 20.82 | 15.76 | 6 | 50200 | 64 | 50554854 |
Schistocytosis | 20.82 | 15.76 | 5 | 50201 | 24 | 50554894 |
Exposure during pregnancy | 20.64 | 15.76 | 57 | 50149 | 120958 | 50433960 |
Acute monocytic leukaemia | 20.58 | 15.76 | 6 | 50200 | 67 | 50554851 |
Sleep disorder | 20.57 | 15.76 | 16 | 50190 | 57267 | 50497651 |
Pulmonary vascular disorder | 20.52 | 15.76 | 9 | 50197 | 346 | 50554572 |
Ganglioneuroma | 20.48 | 15.76 | 7 | 50199 | 135 | 50554783 |
Neutropenic infection | 20.44 | 15.76 | 13 | 50193 | 1074 | 50553844 |
Blood pressure systolic increased | 20.43 | 15.76 | 5 | 50201 | 35444 | 50519474 |
Anaesthesia | 20.40 | 15.76 | 9 | 50197 | 351 | 50554567 |
Gliosis | 20.26 | 15.76 | 8 | 50198 | 235 | 50554683 |
Loss of consciousness | 20.25 | 15.76 | 46 | 50160 | 104307 | 50450611 |
Viral haemorrhagic cystitis | 20.19 | 15.76 | 11 | 50195 | 682 | 50554236 |
Gastrointestinal mucosal disorder | 20.13 | 15.76 | 11 | 50195 | 686 | 50554232 |
Alpha haemolytic streptococcal infection | 20.11 | 15.76 | 12 | 50194 | 885 | 50554033 |
Enterobacter bacteraemia | 20.10 | 15.76 | 8 | 50198 | 240 | 50554678 |
Surgery | 20.07 | 15.76 | 3 | 50203 | 30202 | 50524716 |
Rectal fissure | 20.05 | 15.76 | 10 | 50196 | 516 | 50554402 |
Diabetes mellitus | 19.86 | 15.76 | 12 | 50194 | 49021 | 50505897 |
Myelopathy | 19.79 | 15.76 | 18 | 50188 | 2543 | 50552375 |
Blood stem cell transplant failure | 19.75 | 15.76 | 7 | 50199 | 151 | 50554767 |
Fungal sepsis | 19.73 | 15.76 | 13 | 50193 | 1141 | 50553777 |
Metastasis | 19.70 | 15.76 | 23 | 50183 | 4352 | 50550566 |
VIth nerve paresis | 19.67 | 15.76 | 6 | 50200 | 79 | 50554839 |
Neurological decompensation | 19.62 | 15.76 | 17 | 50189 | 2253 | 50552665 |
Listeria encephalitis | 19.62 | 15.76 | 8 | 50198 | 256 | 50554662 |
Infusion related reaction | 19.57 | 15.76 | 94 | 50112 | 169463 | 50385455 |
Dry eye | 19.55 | 15.76 | 4 | 50202 | 32091 | 50522827 |
Nervous system disorder | 19.47 | 15.76 | 47 | 50159 | 16176 | 50538742 |
Odynophagia | 19.46 | 15.76 | 28 | 50178 | 6504 | 50548414 |
Radiation oesophagitis | 19.39 | 15.76 | 8 | 50198 | 264 | 50554654 |
Cytomegalovirus infection reactivation | 19.37 | 15.76 | 18 | 50188 | 2613 | 50552305 |
Pneumocystis jirovecii pneumonia | 19.25 | 15.76 | 44 | 50162 | 14619 | 50540299 |
Wheezing | 19.09 | 15.76 | 20 | 50186 | 62027 | 50492891 |
Amnesia | 19.09 | 15.76 | 9 | 50197 | 42251 | 50512667 |
Metastases to breast | 19.08 | 15.76 | 8 | 50198 | 275 | 50554643 |
Rash pruritic | 18.98 | 15.76 | 12 | 50194 | 47834 | 50507084 |
Confusional state | 18.71 | 15.76 | 108 | 50098 | 185820 | 50369098 |
Adrenocortical carcinoma | 18.64 | 15.76 | 5 | 50201 | 40 | 50554878 |
Cerebral salt-wasting syndrome | 18.53 | 15.76 | 5 | 50201 | 41 | 50554877 |
Mesenteric haemorrhage | 18.53 | 15.76 | 5 | 50201 | 41 | 50554877 |
Lung infiltration | 18.49 | 15.76 | 41 | 50165 | 13352 | 50541566 |
Mucosal erosion | 18.45 | 15.76 | 13 | 50193 | 1274 | 50553644 |
Choriocarcinoma | 18.42 | 15.76 | 5 | 50201 | 42 | 50554876 |
Fluid retention | 18.37 | 15.76 | 14 | 50192 | 50635 | 50504283 |
Stomatitis | 18.32 | 15.76 | 167 | 50039 | 101177 | 50453741 |
Drug ineffective | 18.26 | 15.76 | 648 | 49558 | 818685 | 49736233 |
Oral fungal infection | 18.23 | 15.76 | 17 | 50189 | 2478 | 50552440 |
Embolism | 18.08 | 15.76 | 28 | 50178 | 6940 | 50547978 |
Pneumonia respiratory syncytial viral | 18.06 | 15.76 | 10 | 50196 | 640 | 50554278 |
Hypoglossal nerve paresis | 18.05 | 15.76 | 6 | 50200 | 106 | 50554812 |
Intra-abdominal haemorrhage | 17.93 | 15.76 | 16 | 50190 | 2204 | 50552714 |
Left ventricular dysfunction | 17.83 | 15.76 | 35 | 50171 | 10471 | 50544447 |
Ewing's sarcoma | 17.75 | 15.76 | 3 | 50203 | 0 | 50554918 |
Transdifferentiation of neoplasm | 17.66 | 15.76 | 4 | 50202 | 14 | 50554904 |
Hot flush | 17.63 | 15.76 | 11 | 50195 | 44158 | 50510760 |
Agranulocytosis | 17.62 | 15.76 | 54 | 50152 | 21367 | 50533551 |
Product administered to patient of inappropriate age | 17.47 | 15.76 | 17 | 50189 | 2613 | 50552305 |
Vascular compression | 17.45 | 15.76 | 6 | 50200 | 118 | 50554800 |
Cardiopulmonary failure | 17.34 | 15.76 | 19 | 50187 | 3354 | 50551564 |
Haematochezia | 17.25 | 15.76 | 9 | 50197 | 39873 | 50515045 |
Carcinoid crisis | 17.16 | 15.76 | 7 | 50199 | 224 | 50554694 |
Angiocentric lymphoma | 16.68 | 15.76 | 9 | 50197 | 547 | 50554371 |
Aortic thrombosis | 16.57 | 15.76 | 11 | 50195 | 978 | 50553940 |
Hyperkalaemia | 16.56 | 15.76 | 14 | 50192 | 48075 | 50506843 |
Human chorionic gonadotropin increased | 16.47 | 15.76 | 12 | 50194 | 1239 | 50553679 |
Growth hormone deficiency | 16.41 | 15.76 | 6 | 50200 | 142 | 50554776 |
Skin discolouration | 16.37 | 15.76 | 6 | 50200 | 32751 | 50522167 |
Osteosarcoma metastatic | 16.20 | 15.76 | 4 | 50202 | 22 | 50554896 |
Osteonecrosis of jaw | 16.18 | 15.76 | 6 | 50200 | 32520 | 50522398 |
Meningoencephalitis bacterial | 16.18 | 15.76 | 5 | 50201 | 69 | 50554849 |
B precursor type acute leukaemia | 16.06 | 15.76 | 6 | 50200 | 151 | 50554767 |
Rhabdomyosarcoma recurrent | 15.91 | 15.76 | 4 | 50202 | 24 | 50554894 |
Acute graft versus host disease in liver | 15.90 | 15.76 | 9 | 50197 | 601 | 50554317 |
Low cardiac output syndrome | 15.89 | 15.76 | 7 | 50199 | 272 | 50554646 |
Immune-mediated enterocolitis | 15.88 | 15.76 | 11 | 50195 | 1049 | 50553869 |
Pharyngeal inflammation | 15.87 | 15.76 | 9 | 50197 | 603 | 50554315 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 2877.07 | 14.68 | 2243 | 66348 | 109997 | 29395939 |
Neutropenia | 950.15 | 14.68 | 1337 | 67254 | 130374 | 29375562 |
Mucosal inflammation | 692.97 | 14.68 | 579 | 68012 | 31016 | 29474920 |
Bone marrow failure | 662.74 | 14.68 | 532 | 68059 | 26917 | 29479019 |
Pancytopenia | 588.89 | 14.68 | 838 | 67753 | 82330 | 29423606 |
Acute myeloid leukaemia | 575.33 | 14.68 | 399 | 68192 | 16114 | 29489822 |
Product use in unapproved indication | 569.49 | 14.68 | 844 | 67747 | 86031 | 29419905 |
Myelodysplastic syndrome | 534.88 | 14.68 | 393 | 68198 | 17401 | 29488535 |
Thrombocytopenia | 509.53 | 14.68 | 1026 | 67565 | 133797 | 29372139 |
Myelosuppression | 482.05 | 14.68 | 319 | 68272 | 11908 | 29494028 |
Off label use | 450.47 | 14.68 | 1622 | 66969 | 299178 | 29206758 |
Haematotoxicity | 347.43 | 14.68 | 208 | 68383 | 6491 | 29499445 |
Venoocclusive liver disease | 346.41 | 14.68 | 210 | 68381 | 6707 | 29499229 |
Second primary malignancy | 308.87 | 14.68 | 193 | 68398 | 6512 | 29499424 |
Malignant neoplasm progression | 290.15 | 14.68 | 572 | 68019 | 73287 | 29432649 |
Disease progression | 265.19 | 14.68 | 586 | 68005 | 81330 | 29424606 |
Sepsis | 261.36 | 14.68 | 825 | 67766 | 141857 | 29364079 |
Tumour lysis syndrome | 250.76 | 14.68 | 228 | 68363 | 13656 | 29492280 |
Septic shock | 246.22 | 14.68 | 485 | 68106 | 62075 | 29443861 |
Febrile bone marrow aplasia | 245.10 | 14.68 | 173 | 68418 | 7178 | 29498758 |
Neutrophil count decreased | 226.30 | 14.68 | 381 | 68210 | 43186 | 29462750 |
Neutropenic sepsis | 214.56 | 14.68 | 194 | 68397 | 11533 | 29494403 |
Fall | 210.89 | 14.68 | 74 | 68517 | 177104 | 29328832 |
Diffuse large B-cell lymphoma recurrent | 209.84 | 14.68 | 108 | 68483 | 2489 | 29503447 |
Neoplasm progression | 189.89 | 14.68 | 225 | 68366 | 18387 | 29487549 |
Haemophagocytic lymphohistiocytosis | 186.74 | 14.68 | 171 | 68420 | 10333 | 29495603 |
Leukopenia | 184.25 | 14.68 | 400 | 68191 | 54803 | 29451133 |
Cytopenia | 180.16 | 14.68 | 163 | 68428 | 9696 | 29496240 |
Product dose omission issue | 171.07 | 14.68 | 14 | 68577 | 96369 | 29409567 |
Malignant transformation | 161.91 | 14.68 | 64 | 68527 | 770 | 29505166 |
Therapy partial responder | 158.75 | 14.68 | 116 | 68475 | 5083 | 29500853 |
Posterior reversible encephalopathy syndrome | 147.74 | 14.68 | 140 | 68451 | 8836 | 29497100 |
Pyrexia | 141.27 | 14.68 | 1143 | 67448 | 286479 | 29219457 |
Dizziness | 140.29 | 14.68 | 140 | 68451 | 189544 | 29316392 |
Cardiotoxicity | 136.20 | 14.68 | 102 | 68489 | 4642 | 29501294 |
Diffuse large B-cell lymphoma refractory | 135.59 | 14.68 | 58 | 68533 | 864 | 29505072 |
Fatigue | 134.70 | 14.68 | 339 | 68252 | 316482 | 29189454 |
Venoocclusive disease | 132.05 | 14.68 | 79 | 68512 | 2460 | 29503476 |
Stomatitis | 130.76 | 14.68 | 275 | 68316 | 36838 | 29469098 |
Bronchopulmonary aspergillosis | 130.50 | 14.68 | 152 | 68439 | 12192 | 29493744 |
Cystitis haemorrhagic | 129.95 | 14.68 | 100 | 68491 | 4742 | 29501194 |
Aplasia | 129.39 | 14.68 | 93 | 68498 | 3970 | 29501966 |
Overdose | 123.07 | 14.68 | 19 | 68572 | 79800 | 29426136 |
Aspergillus infection | 121.51 | 14.68 | 136 | 68455 | 10445 | 29495491 |
Stem cell transplant | 119.67 | 14.68 | 68 | 68523 | 1919 | 29504017 |
Bacteraemia | 115.88 | 14.68 | 165 | 68426 | 16158 | 29489778 |
Arthralgia | 113.93 | 14.68 | 94 | 68497 | 139523 | 29366413 |
Insomnia | 112.67 | 14.68 | 33 | 68558 | 88728 | 29417208 |
Depression | 109.28 | 14.68 | 31 | 68560 | 85116 | 29420820 |
Neoplasm recurrence | 106.69 | 14.68 | 63 | 68528 | 1914 | 29504022 |
Encephalopathy | 104.69 | 14.68 | 226 | 68365 | 30817 | 29475119 |
Fungal infection | 104.09 | 14.68 | 143 | 68448 | 13542 | 29492394 |
Neutropenic colitis | 102.53 | 14.68 | 66 | 68525 | 2345 | 29503591 |
Drug interaction | 102.12 | 14.68 | 189 | 68402 | 197196 | 29308740 |
Joint swelling | 101.26 | 14.68 | 3 | 68588 | 49627 | 29456309 |
Anaemia | 100.76 | 14.68 | 803 | 67788 | 200148 | 29305788 |
Malaise | 100.41 | 14.68 | 134 | 68457 | 159468 | 29346468 |
Tremor | 99.65 | 14.68 | 24 | 68567 | 73514 | 29432422 |
Peripheral swelling | 98.64 | 14.68 | 15 | 68576 | 63724 | 29442212 |
Blood pressure increased | 98.23 | 14.68 | 25 | 68566 | 73778 | 29432158 |
Acute graft versus host disease | 98.06 | 14.68 | 92 | 68499 | 5732 | 29500204 |
Pain | 97.02 | 14.68 | 155 | 68436 | 171277 | 29334659 |
Respiratory failure | 94.80 | 14.68 | 461 | 68130 | 96670 | 29409266 |
Anxiety | 94.19 | 14.68 | 40 | 68551 | 85325 | 29420611 |
Rash | 92.74 | 14.68 | 188 | 68403 | 189631 | 29316305 |
Disease recurrence | 90.40 | 14.68 | 145 | 68446 | 15769 | 29490167 |
Multiple organ dysfunction syndrome | 81.64 | 14.68 | 326 | 68265 | 62790 | 29443146 |
Drug resistance | 81 | 14.68 | 164 | 68427 | 21376 | 29484560 |
Hepatitis B reactivation | 80.82 | 14.68 | 64 | 68527 | 3165 | 29502771 |
Cytomegalovirus infection | 78.25 | 14.68 | 169 | 68422 | 23046 | 29482890 |
Death | 77.55 | 14.68 | 471 | 68120 | 341613 | 29164323 |
Anaplastic lymphoma kinase gene mutation | 74.79 | 14.68 | 22 | 68569 | 96 | 29505840 |
Sweat gland tumour | 74.36 | 14.68 | 30 | 68561 | 382 | 29505554 |
Progressive multifocal leukoencephalopathy | 73.79 | 14.68 | 96 | 68495 | 8623 | 29497313 |
Enterococcal bacteraemia | 72.79 | 14.68 | 45 | 68546 | 1488 | 29504448 |
White blood cell count decreased | 71.05 | 14.68 | 381 | 68210 | 82981 | 29422955 |
Renal salt-wasting syndrome | 69.88 | 14.68 | 23 | 68568 | 155 | 29505781 |
Inappropriate schedule of product administration | 69.87 | 14.68 | 10 | 68581 | 44462 | 29461474 |
Cardiac failure congestive | 69.59 | 14.68 | 46 | 68545 | 76535 | 29429401 |
Neurotoxicity | 68.21 | 14.68 | 122 | 68469 | 14491 | 29491445 |
Musculoskeletal stiffness | 67.65 | 14.68 | 5 | 68586 | 37453 | 29468483 |
Colitis | 67.64 | 14.68 | 192 | 68399 | 31056 | 29474880 |
Nasopharyngitis | 67.35 | 14.68 | 27 | 68564 | 59638 | 29446298 |
Weight increased | 67.08 | 14.68 | 48 | 68543 | 76619 | 29429317 |
Coronary artery disease | 67.00 | 14.68 | 11 | 68580 | 44179 | 29461757 |
Nephropathy toxic | 66.63 | 14.68 | 102 | 68489 | 10654 | 29495282 |
Somnolence | 66.33 | 14.68 | 72 | 68519 | 93883 | 29412053 |
Systemic mycosis | 65.84 | 14.68 | 40 | 68551 | 1281 | 29504655 |
Pruritus | 65.70 | 14.68 | 106 | 68485 | 116743 | 29389193 |
Clostridium difficile colitis | 65.16 | 14.68 | 113 | 68478 | 13099 | 29492837 |
Pulmonary toxicity | 65.16 | 14.68 | 68 | 68523 | 4822 | 29501114 |
Lymphopenia | 64.48 | 14.68 | 114 | 68477 | 13419 | 29492517 |
Aggression | 63.46 | 14.68 | 5 | 68586 | 35536 | 29470400 |
Candida infection | 62.16 | 14.68 | 120 | 68471 | 15105 | 29490831 |
Cytomegalovirus chorioretinitis | 62.04 | 14.68 | 55 | 68536 | 3183 | 29502753 |
Muscle spasms | 62.02 | 14.68 | 37 | 68554 | 65045 | 29440891 |
Hepatitis B | 61.99 | 14.68 | 70 | 68521 | 5427 | 29500509 |
Weight decreased | 61.92 | 14.68 | 164 | 68427 | 150741 | 29355195 |
Acute promyelocytic leukaemia | 61.54 | 14.68 | 27 | 68564 | 429 | 29505507 |
Adenovirus infection | 61.34 | 14.68 | 63 | 68528 | 4384 | 29501552 |
Platelet count decreased | 61.17 | 14.68 | 434 | 68157 | 104238 | 29401698 |
Oedema peripheral | 61.02 | 14.68 | 91 | 68500 | 103466 | 29402470 |
Feeling abnormal | 60.86 | 14.68 | 25 | 68566 | 54420 | 29451516 |
Epstein-Barr virus infection | 60.85 | 14.68 | 76 | 68515 | 6553 | 29499383 |
Chest pain | 60.70 | 14.68 | 104 | 68487 | 111869 | 29394067 |
BK virus infection | 60.13 | 14.68 | 64 | 68527 | 4643 | 29501293 |
Blood glucose increased | 59.86 | 14.68 | 31 | 68560 | 58953 | 29446983 |
Enterococcal infection | 59.29 | 14.68 | 84 | 68507 | 8184 | 29497752 |
Osteosarcoma | 59.23 | 14.68 | 21 | 68570 | 182 | 29505754 |
Renal tubular disorder | 58.85 | 14.68 | 61 | 68530 | 4291 | 29501645 |
Myocardial infarction | 58.37 | 14.68 | 104 | 68487 | 110192 | 29395744 |
Headache | 57.98 | 14.68 | 208 | 68383 | 173799 | 29332137 |
Myalgia | 56.48 | 14.68 | 53 | 68538 | 73966 | 29431970 |
Chronic graft versus host disease | 55.43 | 14.68 | 57 | 68534 | 3972 | 29501964 |
Staphylococcal bacteraemia | 55.38 | 14.68 | 75 | 68516 | 7004 | 29498932 |
Lymphadenopathy | 55.27 | 14.68 | 155 | 68436 | 24894 | 29481042 |
Neuropathy peripheral | 54.75 | 14.68 | 316 | 68275 | 70711 | 29435225 |
Asthma | 54.62 | 14.68 | 7 | 68584 | 33842 | 29472094 |
Pneumonitis | 53.72 | 14.68 | 165 | 68426 | 27879 | 29478057 |
Chloroma | 53.61 | 14.68 | 25 | 68566 | 461 | 29505475 |
Rhabdomyolysis | 53.27 | 14.68 | 38 | 68553 | 60770 | 29445166 |
Hospitalisation | 53.24 | 14.68 | 20 | 68571 | 45968 | 29459968 |
Cerebrovascular accident | 53.11 | 14.68 | 60 | 68531 | 76851 | 29429085 |
Hypogammaglobulinaemia | 53.07 | 14.68 | 67 | 68524 | 5840 | 29500096 |
Pneumonia klebsiella | 52.84 | 14.68 | 46 | 68545 | 2598 | 29503338 |
Thrombotic microangiopathy | 51.92 | 14.68 | 81 | 68510 | 8600 | 29497336 |
Pneumocystis jirovecii pneumonia | 51.86 | 14.68 | 118 | 68473 | 16661 | 29489275 |
Vena cava thrombosis | 51.19 | 14.68 | 31 | 68560 | 987 | 29504949 |
Incorrect dose administered | 50.47 | 14.68 | 8 | 68583 | 32976 | 29472960 |
Acute graft versus host disease in skin | 50.23 | 14.68 | 58 | 68533 | 4606 | 29501330 |
Drug hypersensitivity | 49.86 | 14.68 | 51 | 68540 | 68355 | 29437581 |
Bacterial sepsis | 49.84 | 14.68 | 58 | 68533 | 4645 | 29501291 |
Pulmonary vascular disorder | 49.53 | 14.68 | 25 | 68566 | 552 | 29505384 |
Hyperkalaemia | 49.18 | 14.68 | 42 | 68549 | 61350 | 29444586 |
Epstein-Barr virus associated lymphoproliferative disorder | 49.07 | 14.68 | 37 | 68554 | 1701 | 29504235 |
Ameloblastoma | 48.69 | 14.68 | 15 | 68576 | 79 | 29505857 |
Retinal haemorrhage | 48.49 | 14.68 | 56 | 68535 | 4448 | 29501488 |
Diffuse large B-cell lymphoma | 48.35 | 14.68 | 66 | 68525 | 6210 | 29499726 |
Azoospermia | 48.32 | 14.68 | 22 | 68569 | 383 | 29505553 |
Blood stem cell transplant failure | 47.66 | 14.68 | 22 | 68569 | 396 | 29505540 |
Pain in extremity | 47.60 | 14.68 | 117 | 68474 | 110316 | 29395620 |
Papillary thyroid cancer | 46.43 | 14.68 | 24 | 68567 | 558 | 29505378 |
Klebsiella sepsis | 45.67 | 14.68 | 35 | 68556 | 1649 | 29504287 |
Influenza like illness | 44.95 | 14.68 | 3 | 68588 | 24467 | 29481469 |
B-cell lymphoma recurrent | 44.89 | 14.68 | 24 | 68567 | 599 | 29505337 |
Gait disturbance | 44.62 | 14.68 | 63 | 68528 | 73286 | 29432650 |
Agranulocytosis | 44.03 | 14.68 | 125 | 68466 | 20215 | 29485721 |
Arthritis | 43.35 | 14.68 | 4 | 68587 | 25015 | 29480921 |
Refractory cancer | 43.14 | 14.68 | 15 | 68576 | 122 | 29505814 |
Escherichia infection | 43.10 | 14.68 | 65 | 68526 | 6699 | 29499237 |
Balance disorder | 43.10 | 14.68 | 15 | 68576 | 36155 | 29469781 |
Salivary gland cancer | 43.08 | 14.68 | 18 | 68573 | 252 | 29505684 |
Chronic obstructive pulmonary disease | 42.33 | 14.68 | 21 | 68570 | 40934 | 29465002 |
Acute respiratory distress syndrome | 42.13 | 14.68 | 133 | 68458 | 22802 | 29483134 |
Blood creatine phosphokinase increased | 41.77 | 14.68 | 21 | 68570 | 40623 | 29465313 |
Fusarium infection | 41.67 | 14.68 | 27 | 68564 | 970 | 29504966 |
Acute lymphocytic leukaemia | 41.32 | 14.68 | 40 | 68551 | 2591 | 29503345 |
Bradycardia | 41.29 | 14.68 | 55 | 68536 | 65574 | 29440362 |
Pulmonary arteriopathy | 41.06 | 14.68 | 13 | 68578 | 76 | 29505860 |
Bacterial infection | 41.06 | 14.68 | 92 | 68499 | 12856 | 29493080 |
Vision blurred | 40.93 | 14.68 | 21 | 68570 | 40155 | 29465781 |
Graft versus host disease | 40.67 | 14.68 | 77 | 68514 | 9551 | 29496385 |
Hallucination | 40.41 | 14.68 | 27 | 68564 | 44685 | 29461251 |
Hypoglycaemia | 40.05 | 14.68 | 32 | 68559 | 48314 | 29457622 |
Sleep disorder | 39.45 | 14.68 | 5 | 68586 | 24381 | 29481555 |
Abdominal discomfort | 39.32 | 14.68 | 32 | 68559 | 47871 | 29458065 |
Loss of personal independence in daily activities | 39.31 | 14.68 | 6 | 68585 | 25434 | 29480502 |
Nephrolithiasis | 39.09 | 14.68 | 6 | 68585 | 25328 | 29480608 |
Central nervous system fungal infection | 39.04 | 14.68 | 18 | 68573 | 323 | 29505613 |
Rheumatoid arthritis | 38.89 | 14.68 | 13 | 68578 | 32139 | 29473797 |
Diaphragm muscle weakness | 38.54 | 14.68 | 14 | 68577 | 131 | 29505805 |
Urinary tract infection | 38.46 | 14.68 | 68 | 68523 | 72286 | 29433650 |
Unevaluable event | 38.02 | 14.68 | 11 | 68580 | 29840 | 29476096 |
Recurrent cancer | 37.86 | 14.68 | 27 | 68564 | 1138 | 29504798 |
Hyperhidrosis | 37.72 | 14.68 | 57 | 68534 | 64483 | 29441453 |
Psoriasis | 37.32 | 14.68 | 14 | 68577 | 32213 | 29473723 |
Ototoxicity | 37.00 | 14.68 | 30 | 68561 | 1535 | 29504401 |
Drug reaction with eosinophilia and systemic symptoms | 36.24 | 14.68 | 10 | 68581 | 27982 | 29477954 |
Diabetes mellitus | 36.06 | 14.68 | 24 | 68567 | 39807 | 29466129 |
Heart rate decreased | 36.02 | 14.68 | 7 | 68584 | 24905 | 29481031 |
Systemic candida | 35.86 | 14.68 | 38 | 68553 | 2742 | 29503194 |
Metastasis | 35.86 | 14.68 | 42 | 68549 | 3387 | 29502549 |
Medulloblastoma recurrent | 35.54 | 14.68 | 11 | 68580 | 59 | 29505877 |
Loss of consciousness | 35.52 | 14.68 | 74 | 68517 | 73982 | 29431954 |
Teratoma | 35.45 | 14.68 | 9 | 68582 | 19 | 29505917 |
Osteonecrosis | 35.23 | 14.68 | 89 | 68502 | 13430 | 29492506 |
Urticaria | 35.21 | 14.68 | 45 | 68546 | 54615 | 29451321 |
Escherichia bacteraemia | 34.99 | 14.68 | 38 | 68553 | 2820 | 29503116 |
Metastases to meninges | 34.79 | 14.68 | 26 | 68565 | 1179 | 29504757 |
Pseudomonas infection | 34.29 | 14.68 | 77 | 68514 | 10775 | 29495161 |
Leukaemia recurrent | 34.26 | 14.68 | 28 | 68563 | 1449 | 29504487 |
Back pain | 34.19 | 14.68 | 122 | 68469 | 102162 | 29403774 |
Klebsiella infection | 33.84 | 14.68 | 61 | 68530 | 7288 | 29498648 |
Juvenile melanoma benign | 33.83 | 14.68 | 11 | 68580 | 71 | 29505865 |
Electrocardiogram QT prolonged | 33.78 | 14.68 | 21 | 68570 | 36116 | 29469820 |
Angioedema | 33.54 | 14.68 | 16 | 68575 | 31899 | 29474037 |
Dyspnoea | 33.48 | 14.68 | 545 | 68046 | 326187 | 29179749 |
Viral haemorrhagic cystitis | 33.37 | 14.68 | 23 | 68568 | 917 | 29505019 |
Retinopathy proliferative | 33.31 | 14.68 | 11 | 68580 | 75 | 29505861 |
Extravasation | 33.23 | 14.68 | 29 | 68562 | 1643 | 29504293 |
Therapy non-responder | 33.22 | 14.68 | 151 | 68440 | 30760 | 29475176 |
Ganglioneuroblastoma | 33.21 | 14.68 | 9 | 68582 | 27 | 29505909 |
Metastases to liver | 32.95 | 14.68 | 80 | 68511 | 11776 | 29494160 |
Aortic thrombosis | 32.36 | 14.68 | 20 | 68571 | 661 | 29505275 |
Fanconi syndrome | 32.33 | 14.68 | 28 | 68563 | 1570 | 29504366 |
Neuroblastoma | 31.81 | 14.68 | 12 | 68579 | 126 | 29505810 |
Memory impairment | 31.66 | 14.68 | 23 | 68568 | 36447 | 29469489 |
Pulmonary veno-occlusive disease | 31.48 | 14.68 | 17 | 68574 | 433 | 29505503 |
Cellulitis gangrenous | 31.24 | 14.68 | 13 | 68578 | 180 | 29505756 |
Delayed puberty | 30.92 | 14.68 | 13 | 68578 | 185 | 29505751 |
Gastrointestinal toxicity | 30.87 | 14.68 | 31 | 68560 | 2100 | 29503836 |
Pneumonia aspiration | 30.82 | 14.68 | 24 | 68567 | 36713 | 29469223 |
Stenotrophomonas infection | 30.60 | 14.68 | 28 | 68563 | 1689 | 29504247 |
Injury | 30.58 | 14.68 | 4 | 68587 | 19042 | 29486894 |
Cardiac disorder | 30.44 | 14.68 | 25 | 68566 | 37238 | 29468698 |
Toxic encephalopathy | 30.36 | 14.68 | 45 | 68546 | 4567 | 29501369 |
Aspiration bone marrow abnormal | 30.18 | 14.68 | 11 | 68580 | 104 | 29505832 |
Haematochezia | 29.98 | 14.68 | 25 | 68566 | 36958 | 29468978 |
Carotid artery thrombosis | 29.85 | 14.68 | 15 | 68576 | 328 | 29505608 |
Minimal residual disease | 29.85 | 14.68 | 15 | 68576 | 328 | 29505608 |
Serotonin syndrome | 29.81 | 14.68 | 3 | 68588 | 17509 | 29488427 |
Metastases to muscle | 29.55 | 14.68 | 13 | 68578 | 208 | 29505728 |
Flagellate dermatitis | 29.52 | 14.68 | 8 | 68583 | 24 | 29505912 |
Mucormycosis | 29.28 | 14.68 | 47 | 68544 | 5111 | 29500825 |
Peripheral T-cell lymphoma unspecified | 29.23 | 14.68 | 16 | 68575 | 419 | 29505517 |
Metastases to retroperitoneum | 29.21 | 14.68 | 13 | 68578 | 214 | 29505722 |
Abdominal pain upper | 29.20 | 14.68 | 61 | 68530 | 60932 | 29445004 |
Device related infection | 29.01 | 14.68 | 91 | 68500 | 15545 | 29490391 |
Cytogenetic abnormality | 28.99 | 14.68 | 20 | 68571 | 799 | 29505137 |
Wheezing | 28.81 | 14.68 | 21 | 68570 | 33219 | 29472717 |
Streptococcal bacteraemia | 28.75 | 14.68 | 27 | 68564 | 1684 | 29504252 |
Hepatic candidiasis | 28.66 | 14.68 | 9 | 68582 | 51 | 29505885 |
Human herpesvirus 6 infection | 28.65 | 14.68 | 28 | 68563 | 1835 | 29504101 |
Body height below normal | 28.62 | 14.68 | 13 | 68578 | 225 | 29505711 |
Metastases to lung | 28.56 | 14.68 | 59 | 68532 | 7796 | 29498140 |
Gastrooesophageal reflux disease | 28.48 | 14.68 | 19 | 68572 | 31477 | 29474459 |
Engraftment syndrome | 28.46 | 14.68 | 20 | 68571 | 823 | 29505113 |
Disseminated intravascular coagulation | 28.08 | 14.68 | 106 | 68485 | 19874 | 29486062 |
Rhabdomyosarcoma recurrent | 28.07 | 14.68 | 10 | 68581 | 88 | 29505848 |
Paraneoplastic neurological syndrome | 27.95 | 14.68 | 8 | 68583 | 31 | 29505905 |
Contusion | 27.80 | 14.68 | 19 | 68572 | 31076 | 29474860 |
Refractory anaemia with an excess of blasts | 27.78 | 14.68 | 15 | 68576 | 382 | 29505554 |
Pulmonary haemorrhage | 27.33 | 14.68 | 64 | 68527 | 9206 | 29496730 |
Cytomegalovirus viraemia | 27.26 | 14.68 | 51 | 68540 | 6269 | 29499667 |
Enteritis | 27.07 | 14.68 | 53 | 68538 | 6738 | 29499198 |
Hepatotoxicity | 26.96 | 14.68 | 97 | 68494 | 17770 | 29488166 |
Encephalitis enteroviral | 26.86 | 14.68 | 11 | 68580 | 146 | 29505790 |
Diabetic ketoacidosis | 26.73 | 14.68 | 3 | 68588 | 16070 | 29489866 |
Cardio-respiratory arrest | 26.48 | 14.68 | 48 | 68543 | 50553 | 29455383 |
Influenza | 26.44 | 14.68 | 35 | 68556 | 41846 | 29464090 |
Capillary leak syndrome | 26.37 | 14.68 | 27 | 68564 | 1872 | 29504064 |
Lactic acidosis | 26.35 | 14.68 | 19 | 68572 | 30228 | 29475708 |
Intussusception | 26.24 | 14.68 | 16 | 68575 | 516 | 29505420 |
Erectile dysfunction | 26.16 | 14.68 | 5 | 68586 | 18004 | 29487932 |
Swelling | 26.04 | 14.68 | 26 | 68565 | 35257 | 29470679 |
Intestinal atresia | 26.01 | 14.68 | 9 | 68582 | 72 | 29505864 |
Hypoalbuminaemia | 25.98 | 14.68 | 67 | 68524 | 10238 | 29495698 |
Wrong technique in product usage process | 25.78 | 14.68 | 21 | 68570 | 31407 | 29474529 |
Blood cholesterol increased | 25.71 | 14.68 | 3 | 68588 | 15592 | 29490344 |
Herpes simplex | 25.66 | 14.68 | 43 | 68548 | 4847 | 29501089 |
Mobility decreased | 25.48 | 14.68 | 14 | 68577 | 25766 | 29480170 |
Candida sepsis | 25.44 | 14.68 | 21 | 68570 | 1102 | 29504834 |
Cytomegalovirus infection reactivation | 25.34 | 14.68 | 35 | 68556 | 3329 | 29502607 |
Embolism | 25.31 | 14.68 | 52 | 68539 | 6844 | 29499092 |
Adverse drug reaction | 25.30 | 14.68 | 12 | 68579 | 24008 | 29481928 |
Metastases to central nervous system | 25.27 | 14.68 | 53 | 68538 | 7078 | 29498858 |
Abnormal behaviour | 25.22 | 14.68 | 11 | 68580 | 23116 | 29482820 |
Bronchitis | 25.17 | 14.68 | 29 | 68562 | 36839 | 29469097 |
Eosinophilia | 25.04 | 14.68 | 10 | 68581 | 22151 | 29483785 |
Prostate cancer | 25.03 | 14.68 | 14 | 68577 | 25513 | 29480423 |
Hepatic infection fungal | 25.00 | 14.68 | 11 | 68580 | 176 | 29505760 |
Acute lymphocytic leukaemia recurrent | 24.96 | 14.68 | 30 | 68561 | 2486 | 29503450 |
Blood lactate dehydrogenase increased | 24.62 | 14.68 | 99 | 68492 | 19110 | 29486826 |
Toxicity to various agents | 24.51 | 14.68 | 271 | 68320 | 173390 | 29332546 |
Dyskinesia | 24.45 | 14.68 | 8 | 68583 | 20053 | 29485883 |
Streptococcal infection | 24.26 | 14.68 | 40 | 68551 | 4448 | 29501488 |
Treatment noncompliance | 24.17 | 14.68 | 13 | 68578 | 24214 | 29481722 |
Liver function test abnormal | 24.12 | 14.68 | 19 | 68572 | 28899 | 29477037 |
Gastrointestinal mucosal disorder | 23.90 | 14.68 | 13 | 68578 | 336 | 29505600 |
Blood pressure systolic increased | 23.80 | 14.68 | 5 | 68586 | 16840 | 29489096 |
Therapeutic product effect decreased | 23.76 | 14.68 | 20 | 68571 | 29431 | 29476505 |
Neoplasm | 23.74 | 14.68 | 38 | 68553 | 4123 | 29501813 |
Myelopathy | 23.74 | 14.68 | 26 | 68565 | 1948 | 29503988 |
Myeloid leukaemia | 23.73 | 14.68 | 13 | 68578 | 341 | 29505595 |
Short stature | 23.69 | 14.68 | 8 | 68583 | 59 | 29505877 |
Disturbance in attention | 23.67 | 14.68 | 10 | 68581 | 21414 | 29484522 |
Flatulence | 23.54 | 14.68 | 6 | 68585 | 17703 | 29488233 |
Geotrichum infection | 23.54 | 14.68 | 14 | 68577 | 431 | 29505505 |
Trichosporon infection | 23.53 | 14.68 | 16 | 68575 | 624 | 29505312 |
Hyperbilirubinaemia | 23.32 | 14.68 | 82 | 68509 | 14852 | 29491084 |
Accidental overdose | 23.31 | 14.68 | 6 | 68585 | 17587 | 29488349 |
Graft versus host disease in gastrointestinal tract | 23.21 | 14.68 | 33 | 68558 | 3225 | 29502711 |
Epstein-Barr virus infection reactivation | 23.20 | 14.68 | 15 | 68576 | 537 | 29505399 |
Arrhythmia | 23.20 | 14.68 | 23 | 68568 | 31290 | 29474646 |
Hypertensive hydrocephalus | 23.12 | 14.68 | 8 | 68583 | 64 | 29505872 |
Blood electrolytes abnormal | 22.92 | 14.68 | 18 | 68573 | 879 | 29505057 |
Nervous system disorder | 22.81 | 14.68 | 73 | 68518 | 12601 | 29493335 |
Hypophosphataemia | 22.59 | 14.68 | 54 | 68537 | 7870 | 29498066 |
Transformation to acute myeloid leukaemia | 22.34 | 14.68 | 16 | 68575 | 679 | 29505257 |
Neuroblastoma recurrent | 22.30 | 14.68 | 8 | 68583 | 72 | 29505864 |
Graft versus host disease in skin | 22.29 | 14.68 | 33 | 68558 | 3346 | 29502590 |
Head injury | 22.26 | 14.68 | 5 | 68586 | 16076 | 29489860 |
Syncope | 22.21 | 14.68 | 105 | 68486 | 81266 | 29424670 |
Carbamoyl phosphate synthetase deficiency | 22.14 | 14.68 | 6 | 68585 | 18 | 29505918 |
Mantle cell lymphoma recurrent | 22.09 | 14.68 | 14 | 68577 | 484 | 29505452 |
Papilloedema | 21.94 | 14.68 | 27 | 68564 | 2293 | 29503643 |
Graft versus host disease in liver | 21.91 | 14.68 | 19 | 68572 | 1067 | 29504869 |
Neutrophil count abnormal | 21.87 | 14.68 | 22 | 68569 | 1493 | 29504443 |
Bicytopenia | 21.86 | 14.68 | 24 | 68567 | 1803 | 29504133 |
Dehydration | 21.85 | 14.68 | 166 | 68425 | 114582 | 29391354 |
Cardiac arrest | 21.33 | 14.68 | 114 | 68477 | 85477 | 29420459 |
T-cell type acute leukaemia | 21.29 | 14.68 | 8 | 68583 | 83 | 29505853 |
Aplastic anaemia | 21.22 | 14.68 | 51 | 68540 | 7459 | 29498477 |
Radiation pneumonitis | 21.17 | 14.68 | 26 | 68565 | 2203 | 29503733 |
Stomatitis necrotising | 21.12 | 14.68 | 8 | 68583 | 85 | 29505851 |
Transient ischaemic attack | 21.09 | 14.68 | 14 | 68577 | 23256 | 29482680 |
Escherichia sepsis | 21.09 | 14.68 | 35 | 68556 | 3914 | 29502022 |
Flushing | 21.03 | 14.68 | 127 | 68464 | 28865 | 29477071 |
Faeces discoloured | 20.97 | 14.68 | 3 | 68588 | 13348 | 29492588 |
Autoimmune neutropenia | 20.96 | 14.68 | 11 | 68580 | 264 | 29505672 |
Peripheral sensory neuropathy | 20.88 | 14.68 | 44 | 68547 | 5895 | 29500041 |
Rectal haemorrhage | 20.67 | 14.68 | 30 | 68561 | 34519 | 29471417 |
Nasal congestion | 20.56 | 14.68 | 9 | 68582 | 18870 | 29487066 |
Traumatic lung injury | 20.56 | 14.68 | 19 | 68572 | 1161 | 29504775 |
Gallbladder empyema | 20.23 | 14.68 | 7 | 68584 | 56 | 29505880 |
Metastases to spleen | 20.22 | 14.68 | 12 | 68579 | 368 | 29505568 |
Visceral oedema | 20.22 | 14.68 | 5 | 68586 | 9 | 29505927 |
Adrenocortical carcinoma | 20.07 | 14.68 | 6 | 68585 | 28 | 29505908 |
Skin exfoliation | 20.02 | 14.68 | 14 | 68577 | 22631 | 29483305 |
Diverticulitis | 19.98 | 14.68 | 8 | 68583 | 17696 | 29488240 |
Pneumonia adenoviral | 19.96 | 14.68 | 9 | 68582 | 153 | 29505783 |
Hepatosplenomegaly | 19.92 | 14.68 | 33 | 68558 | 3684 | 29502252 |
Inflammatory pseudotumour | 19.90 | 14.68 | 6 | 68585 | 29 | 29505907 |
International normalised ratio increased | 19.89 | 14.68 | 46 | 68545 | 44326 | 29461610 |
Emotional distress | 19.89 | 14.68 | 4 | 68587 | 13891 | 29492045 |
Dry mouth | 19.89 | 14.68 | 13 | 68578 | 21771 | 29484165 |
Dry skin | 19.84 | 14.68 | 15 | 68576 | 23292 | 29482644 |
Chromaturia | 19.82 | 14.68 | 3 | 68588 | 12799 | 29493137 |
Intestinal perforation | 19.79 | 14.68 | 52 | 68539 | 8034 | 29497902 |
Basal cell naevus syndrome | 19.73 | 14.68 | 6 | 68585 | 30 | 29505906 |
Enterocolitis | 19.62 | 14.68 | 46 | 68545 | 6620 | 29499316 |
Leukoencephalopathy | 19.60 | 14.68 | 33 | 68558 | 3734 | 29502202 |
Testicular malignant teratoma | 19.55 | 14.68 | 5 | 68586 | 11 | 29505925 |
Lung infiltration | 19.55 | 14.68 | 66 | 68525 | 11713 | 29494223 |
Heart rate increased | 19.43 | 14.68 | 38 | 68553 | 38900 | 29467036 |
Osteonecrosis of jaw | 19.40 | 14.68 | 7 | 68584 | 16503 | 29489433 |
Pneumonia fungal | 19.39 | 14.68 | 42 | 68549 | 5735 | 29500201 |
Road traffic accident | 19.33 | 14.68 | 6 | 68585 | 15555 | 29490381 |
Laboratory test abnormal | 19.28 | 14.68 | 9 | 68582 | 18176 | 29487760 |
Staphylococcal infection | 19.28 | 14.68 | 125 | 68466 | 29115 | 29476821 |
Arterial thrombosis | 19.28 | 14.68 | 20 | 68571 | 1408 | 29504528 |
Paternal exposure timing unspecified | 19.26 | 14.68 | 6 | 68585 | 33 | 29505903 |
Small cell lung cancer | 19.22 | 14.68 | 22 | 68569 | 1730 | 29504206 |
Meningitis tuberculous | 19.20 | 14.68 | 14 | 68577 | 611 | 29505325 |
Confusional state | 19.06 | 14.68 | 197 | 68394 | 127680 | 29378256 |
Therapy responder | 19.06 | 14.68 | 9 | 68582 | 171 | 29505765 |
Pneumocystis jirovecii infection | 19.05 | 14.68 | 20 | 68571 | 1428 | 29504508 |
Migraine | 19.05 | 14.68 | 3 | 68588 | 12427 | 29493509 |
Acute myelomonocytic leukaemia | 19.02 | 14.68 | 8 | 68583 | 114 | 29505822 |
Speech disorder | 18.93 | 14.68 | 16 | 68575 | 23500 | 29482436 |
Amnesia | 18.73 | 14.68 | 15 | 68576 | 22628 | 29483308 |
Myoclonus | 18.70 | 14.68 | 4 | 68587 | 13305 | 29492631 |
Chronic myeloid leukaemia | 18.52 | 14.68 | 23 | 68568 | 1971 | 29503965 |
Scedosporium infection | 18.46 | 14.68 | 15 | 68576 | 770 | 29505166 |
Diabetes mellitus inadequate control | 18.43 | 14.68 | 3 | 68588 | 12131 | 29493805 |
Splenic infarction | 18.36 | 14.68 | 22 | 68569 | 1817 | 29504119 |
Spindle cell sarcoma | 18.24 | 14.68 | 8 | 68583 | 127 | 29505809 |
Reticulocytosis | 18.23 | 14.68 | 10 | 68581 | 263 | 29505673 |
Metastases to lymph nodes | 18.06 | 14.68 | 33 | 68558 | 3984 | 29501952 |
Dystrophic calcification | 18.04 | 14.68 | 4 | 68587 | 3 | 29505933 |
Premature ageing | 18.03 | 14.68 | 7 | 68584 | 80 | 29505856 |
Refractory cytopenia with multilineage dysplasia | 17.96 | 14.68 | 8 | 68583 | 132 | 29505804 |
Asthenia | 17.91 | 14.68 | 372 | 68219 | 214878 | 29291058 |
Autoimmune haemolytic anaemia | 17.79 | 14.68 | 32 | 68559 | 3816 | 29502120 |
B-cell lymphoma refractory | 17.74 | 14.68 | 8 | 68583 | 136 | 29505800 |
Subdural haemorrhage | 17.72 | 14.68 | 27 | 68564 | 2808 | 29503128 |
Myelitis transverse | 17.71 | 14.68 | 16 | 68575 | 949 | 29504987 |
Cerebral toxoplasmosis | 17.64 | 14.68 | 19 | 68572 | 1397 | 29504539 |
Medication error | 17.61 | 14.68 | 14 | 68577 | 21197 | 29484739 |
Metastases to bone marrow | 17.60 | 14.68 | 12 | 68579 | 470 | 29505466 |
5q minus syndrome | 17.59 | 14.68 | 8 | 68583 | 139 | 29505797 |
Retinal pigment epitheliopathy | 17.58 | 14.68 | 9 | 68582 | 205 | 29505731 |
Benign prostatic hyperplasia | 17.55 | 14.68 | 3 | 68588 | 11707 | 29494229 |
Mucoepidermoid carcinoma | 17.55 | 14.68 | 5 | 68586 | 19 | 29505917 |
Pneumomediastinum | 17.52 | 14.68 | 21 | 68570 | 1735 | 29504201 |
Musculoskeletal pain | 17.46 | 14.68 | 25 | 68566 | 28928 | 29477008 |
Psychotic disorder | 17.45 | 14.68 | 13 | 68578 | 20341 | 29485595 |
Vertigo | 17.44 | 14.68 | 15 | 68576 | 21846 | 29484090 |
Disorder of orbit | 17.43 | 14.68 | 7 | 68584 | 88 | 29505848 |
Pneumonia cytomegaloviral | 17.41 | 14.68 | 26 | 68565 | 2656 | 29503280 |
Acute myeloid leukaemia recurrent | 17.29 | 14.68 | 21 | 68570 | 1759 | 29504177 |
Agitation | 17.26 | 14.68 | 61 | 68530 | 51243 | 29454693 |
Hyperlipidaemia | 17.25 | 14.68 | 4 | 68587 | 12586 | 29493350 |
Guillain-Barre syndrome | 17.24 | 14.68 | 37 | 68554 | 5021 | 29500915 |
Cardiomyopathy | 17.22 | 14.68 | 74 | 68517 | 14713 | 29491223 |
Prostatic specific antigen increased | 17.20 | 14.68 | 4 | 68587 | 12560 | 29493376 |
Hepatic cirrhosis | 17.19 | 14.68 | 6 | 68585 | 14438 | 29491498 |
Varicella zoster virus infection | 17.07 | 14.68 | 19 | 68572 | 1449 | 29504487 |
Renal infarct | 17.07 | 14.68 | 17 | 68574 | 1140 | 29504796 |
Alpha haemolytic streptococcal infection | 17.05 | 14.68 | 15 | 68576 | 859 | 29505077 |
Granulocyte count decreased | 16.99 | 14.68 | 13 | 68578 | 611 | 29505325 |
Adenomatous polyposis coli | 16.99 | 14.68 | 8 | 68583 | 151 | 29505785 |
Product administration error | 16.93 | 14.68 | 6 | 68585 | 14304 | 29491632 |
Coronary artery thrombosis | 16.84 | 14.68 | 22 | 68569 | 1983 | 29503953 |
CNS ventriculitis | 16.82 | 14.68 | 9 | 68582 | 225 | 29505711 |
Paraesthesia | 16.82 | 14.68 | 66 | 68525 | 53779 | 29452157 |
Lethargy | 16.81 | 14.68 | 39 | 68552 | 37541 | 29468395 |
Cerebral venous thrombosis | 16.73 | 14.68 | 13 | 68578 | 625 | 29505311 |
Gait inability | 16.73 | 14.68 | 11 | 68580 | 18364 | 29487572 |
Pneumothorax | 16.73 | 14.68 | 77 | 68514 | 15765 | 29490171 |
Fanconi syndrome acquired | 16.72 | 14.68 | 21 | 68570 | 1821 | 29504115 |
Acanthamoeba infection | 16.69 | 14.68 | 11 | 68580 | 407 | 29505529 |
Recall phenomenon | 16.47 | 14.68 | 12 | 68579 | 523 | 29505413 |
Poikiloderma | 16.43 | 14.68 | 8 | 68583 | 163 | 29505773 |
Hypoaesthesia | 16.41 | 14.68 | 66 | 68525 | 53401 | 29452535 |
Superior vena cava syndrome | 16.35 | 14.68 | 12 | 68579 | 529 | 29505407 |
Renal disorder | 16.28 | 14.68 | 17 | 68574 | 22578 | 29483358 |
Burns first degree | 16.25 | 14.68 | 4 | 68587 | 7 | 29505929 |
Atypical teratoid/rhabdoid tumour of CNS | 16.25 | 14.68 | 4 | 68587 | 7 | 29505929 |
Skin laceration | 16.22 | 14.68 | 3 | 68588 | 11059 | 29494877 |
Dyspnoea exertional | 16.22 | 14.68 | 38 | 68553 | 36452 | 29469484 |
Blood glucose decreased | 16.21 | 14.68 | 4 | 68587 | 12065 | 29493871 |
Blood culture positive | 16.20 | 14.68 | 34 | 68557 | 4543 | 29501393 |
Testicular germ cell cancer metastatic | 16.17 | 14.68 | 6 | 68585 | 60 | 29505876 |
Neuroendocrine tumour of the lung metastatic | 16.14 | 14.68 | 7 | 68584 | 108 | 29505828 |
Pancreatitis | 16.11 | 14.68 | 35 | 68556 | 34479 | 29471457 |
Chemotherapy | 16.10 | 14.68 | 12 | 68579 | 542 | 29505394 |
Expanded disability status scale score increased | 16.09 | 14.68 | 9 | 68582 | 246 | 29505690 |
Terminal ileitis | 16.08 | 14.68 | 7 | 68584 | 109 | 29505827 |
Blindness cortical | 16.06 | 14.68 | 10 | 68581 | 335 | 29505601 |
Blood pressure decreased | 16.02 | 14.68 | 53 | 68538 | 45424 | 29460512 |
Bacillus bacteraemia | 15.99 | 14.68 | 6 | 68585 | 62 | 29505874 |
Delayed engraftment | 15.97 | 14.68 | 7 | 68584 | 111 | 29505825 |
Chronic myelomonocytic leukaemia | 15.96 | 14.68 | 12 | 68579 | 549 | 29505387 |
Pulmonary fibrosis | 15.91 | 14.68 | 75 | 68516 | 15507 | 29490429 |
Clostridium test positive | 15.91 | 14.68 | 22 | 68569 | 2095 | 29503841 |
Procalcitonin decreased | 15.90 | 14.68 | 4 | 68587 | 8 | 29505928 |
Choriocarcinoma | 15.90 | 14.68 | 4 | 68587 | 8 | 29505928 |
Pleuritic pain | 15.85 | 14.68 | 26 | 68565 | 2879 | 29503057 |
Congenital hepatobiliary anomaly | 15.83 | 14.68 | 5 | 68586 | 29 | 29505907 |
Blastic plasmacytoid dendritic cell neoplasia | 15.82 | 14.68 | 6 | 68585 | 64 | 29505872 |
Hypokalaemia | 15.76 | 14.68 | 182 | 68409 | 50021 | 29455915 |
Platelet transfusion | 15.76 | 14.68 | 16 | 68575 | 1098 | 29504838 |
Hirsutism | 15.75 | 14.68 | 8 | 68583 | 179 | 29505757 |
Primitive neuroectodermal tumour | 15.74 | 14.68 | 6 | 68585 | 65 | 29505871 |
Cerebral artery occlusion | 15.70 | 14.68 | 13 | 68578 | 685 | 29505251 |
Lower respiratory tract infection fungal | 15.63 | 14.68 | 12 | 68579 | 567 | 29505369 |
Pulmonary alveolar haemorrhage | 15.59 | 14.68 | 41 | 68550 | 6339 | 29499597 |
Mediastinum neoplasm | 15.58 | 14.68 | 4 | 68587 | 9 | 29505927 |
Gout | 15.56 | 14.68 | 10 | 68581 | 16901 | 29489035 |
Adverse event | 15.56 | 14.68 | 8 | 68583 | 15283 | 29490653 |
Cytokine release syndrome | 15.54 | 14.68 | 66 | 68525 | 13053 | 29492883 |
Tooth hypoplasia | 15.53 | 14.68 | 7 | 68584 | 119 | 29505817 |
Human herpesvirus 8 infection | 15.46 | 14.68 | 14 | 68577 | 833 | 29505103 |
Subcutaneous emphysema | 15.42 | 14.68 | 15 | 68576 | 977 | 29504959 |
Bone sarcoma | 15.34 | 14.68 | 6 | 68585 | 70 | 29505866 |
Ewing's sarcoma recurrent | 15.29 | 14.68 | 4 | 68587 | 10 | 29505926 |
Mucosal toxicity | 15.28 | 14.68 | 8 | 68583 | 191 | 29505745 |
Clostridium difficile infection | 15.26 | 14.68 | 76 | 68515 | 16065 | 29489871 |
Ischaemic cerebral infarction | 15.26 | 14.68 | 15 | 68576 | 990 | 29504946 |
Platelet count abnormal | 15.24 | 14.68 | 23 | 68568 | 2371 | 29503565 |
Erythema ab igne | 15.21 | 14.68 | 3 | 68588 | 0 | 29505936 |
Li-Fraumeni syndrome | 15.21 | 14.68 | 3 | 68588 | 0 | 29505936 |
Abdominal distension | 15.17 | 14.68 | 55 | 68536 | 45856 | 29460080 |
Salivary gland cancer stage IV | 15.15 | 14.68 | 5 | 68586 | 34 | 29505902 |
Clostridium colitis | 15.14 | 14.68 | 16 | 68575 | 1151 | 29504785 |
Primary hypogonadism | 15.12 | 14.68 | 6 | 68585 | 73 | 29505863 |
Hip fracture | 15.06 | 14.68 | 3 | 68588 | 10489 | 29495447 |
Hepatitis D | 15.03 | 14.68 | 5 | 68586 | 35 | 29505901 |
Fibrinous bronchitis | 15.01 | 14.68 | 4 | 68587 | 11 | 29505925 |
Staphylococcal sepsis | 15.01 | 14.68 | 50 | 68541 | 8812 | 29497124 |
Infected neoplasm | 14.97 | 14.68 | 6 | 68585 | 75 | 29505861 |
Sudden death | 14.93 | 14.68 | 7 | 68584 | 14103 | 29491833 |
Oesophagitis | 14.92 | 14.68 | 61 | 68530 | 11862 | 29494074 |
Pleural effusion | 14.91 | 14.68 | 242 | 68349 | 71666 | 29434270 |
Respiratory arrest | 14.90 | 14.68 | 23 | 68568 | 25810 | 29480126 |
Iris atrophy | 14.90 | 14.68 | 6 | 68585 | 76 | 29505860 |
Stevens-Johnson syndrome | 14.85 | 14.68 | 10 | 68581 | 16487 | 29489449 |
Cerebral artery stenosis | 14.85 | 14.68 | 9 | 68582 | 287 | 29505649 |
Ill-defined disorder | 14.82 | 14.68 | 60 | 68531 | 11618 | 29494318 |
Gene mutation | 14.82 | 14.68 | 15 | 68576 | 1026 | 29504910 |
Pelvic mass | 14.81 | 14.68 | 8 | 68583 | 204 | 29505732 |
Thyroid cancer | 14.77 | 14.68 | 17 | 68574 | 1345 | 29504591 |
Swollen tongue | 14.76 | 14.68 | 5 | 68586 | 12261 | 29493675 |
JC virus infection | 14.69 | 14.68 | 20 | 68571 | 1877 | 29504059 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 4869.79 | 14.05 | 3325 | 104887 | 184332 | 64206188 |
Neutropenia | 1745.56 | 14.05 | 2075 | 106137 | 237549 | 64152971 |
Mucosal inflammation | 1299.57 | 14.05 | 972 | 107240 | 61612 | 64328908 |
Pancytopenia | 1299.02 | 14.05 | 1392 | 106820 | 141917 | 64248603 |
Bone marrow failure | 1296.63 | 14.05 | 875 | 107337 | 47077 | 64343443 |
Acute myeloid leukaemia | 1026.25 | 14.05 | 615 | 107597 | 26848 | 64363672 |
Product use in unapproved indication | 1001.71 | 14.05 | 1352 | 106860 | 175266 | 64215254 |
Thrombocytopenia | 999.64 | 14.05 | 1529 | 106683 | 222272 | 64168248 |
Myelodysplastic syndrome | 941.74 | 14.05 | 583 | 107629 | 26996 | 64363524 |
Off label use | 706.39 | 14.05 | 2493 | 105719 | 630313 | 63760207 |
Venoocclusive liver disease | 687.79 | 14.05 | 336 | 107876 | 9679 | 64380841 |
Myelosuppression | 680.14 | 14.05 | 450 | 107762 | 23380 | 64367140 |
Haematotoxicity | 665.96 | 14.05 | 357 | 107855 | 12539 | 64377981 |
Second primary malignancy | 602.16 | 14.05 | 329 | 107883 | 12008 | 64378512 |
Malignant neoplasm progression | 561.28 | 14.05 | 812 | 107400 | 112059 | 64278461 |
Sepsis | 542.38 | 14.05 | 1194 | 107018 | 229147 | 64161373 |
Disease progression | 525.98 | 14.05 | 891 | 107321 | 140789 | 64249731 |
Febrile bone marrow aplasia | 467.42 | 14.05 | 270 | 107942 | 10985 | 64379535 |
Tumour lysis syndrome | 462.12 | 14.05 | 328 | 107884 | 19112 | 64371408 |
Septic shock | 446.56 | 14.05 | 704 | 107508 | 104733 | 64285787 |
Neutropenic sepsis | 433.14 | 14.05 | 339 | 107873 | 22933 | 64367587 |
Neutrophil count decreased | 420.01 | 14.05 | 580 | 107632 | 76616 | 64313904 |
Haemophagocytic lymphohistiocytosis | 402.22 | 14.05 | 290 | 107922 | 17319 | 64373201 |
Pain | 359.37 | 14.05 | 245 | 107967 | 553266 | 63837254 |
Fall | 358.91 | 14.05 | 126 | 108086 | 416700 | 63973820 |
Arthralgia | 347.45 | 14.05 | 154 | 108058 | 442106 | 63948414 |
Posterior reversible encephalopathy syndrome | 346.58 | 14.05 | 296 | 107916 | 22650 | 64367870 |
Stem cell transplant | 346.07 | 14.05 | 151 | 108061 | 3330 | 64387190 |
Aplasia | 329.82 | 14.05 | 182 | 108030 | 6771 | 64383749 |
Joint swelling | 327.33 | 14.05 | 7 | 108205 | 215375 | 64175145 |
Multiple organ dysfunction syndrome | 322.13 | 14.05 | 596 | 107616 | 100817 | 64289703 |
Leukopenia | 301.69 | 14.05 | 579 | 107633 | 100663 | 64289857 |
Diffuse large B-cell lymphoma recurrent | 301.51 | 14.05 | 133 | 108079 | 3013 | 64387507 |
Pyrexia | 290.05 | 14.05 | 1761 | 106451 | 556883 | 63833637 |
Peripheral swelling | 274.12 | 14.05 | 20 | 108192 | 209133 | 64181387 |
Aspergillus infection | 265.29 | 14.05 | 220 | 107992 | 16159 | 64374361 |
Malignant transformation | 258.49 | 14.05 | 90 | 108122 | 1051 | 64389469 |
Encephalopathy | 254.73 | 14.05 | 397 | 107815 | 58422 | 64332098 |
Anaemia | 247.55 | 14.05 | 1271 | 106941 | 377409 | 64013111 |
Product dose omission issue | 243.13 | 14.05 | 23 | 108189 | 194724 | 64195796 |
Bronchopulmonary aspergillosis | 240.05 | 14.05 | 222 | 107990 | 18863 | 64371657 |
Venoocclusive disease | 233.25 | 14.05 | 120 | 108092 | 3865 | 64386655 |
Cytopenia | 226.34 | 14.05 | 196 | 108016 | 15275 | 64375245 |
Fatigue | 224.67 | 14.05 | 587 | 107625 | 748143 | 63642377 |
Cardiotoxicity | 222.80 | 14.05 | 164 | 108048 | 10110 | 64380410 |
Nasopharyngitis | 220.48 | 14.05 | 33 | 108179 | 196040 | 64194480 |
Rheumatoid arthritis | 220.24 | 14.05 | 14 | 108198 | 164280 | 64226240 |
Bacteraemia | 218.09 | 14.05 | 247 | 107965 | 26664 | 64363856 |
Dizziness | 211.99 | 14.05 | 246 | 107966 | 429917 | 63960603 |
Neoplasm progression | 211.07 | 14.05 | 300 | 107912 | 40664 | 64349856 |
Cytomegalovirus infection | 210.49 | 14.05 | 285 | 107927 | 36914 | 64353606 |
Drug hypersensitivity | 204.20 | 14.05 | 72 | 108140 | 237743 | 64152777 |
Acute graft versus host disease | 203.76 | 14.05 | 148 | 108064 | 8936 | 64381584 |
Platelet count decreased | 201.26 | 14.05 | 679 | 107533 | 167032 | 64223488 |
Neutropenic colitis | 201.18 | 14.05 | 114 | 108098 | 4467 | 64386053 |
Malaise | 199.12 | 14.05 | 223 | 107989 | 396024 | 63994496 |
Headache | 196.39 | 14.05 | 369 | 107843 | 529098 | 63861422 |
Cystitis haemorrhagic | 190.79 | 14.05 | 135 | 108077 | 7821 | 64382699 |
Cytogenetic abnormality | 189.28 | 14.05 | 70 | 108142 | 984 | 64389536 |
Pruritus | 188.37 | 14.05 | 149 | 108063 | 312251 | 64078269 |
Therapy partial responder | 187.87 | 14.05 | 148 | 108064 | 10100 | 64380420 |
Insomnia | 185.76 | 14.05 | 51 | 108161 | 197785 | 64192735 |
Weight increased | 180.75 | 14.05 | 66 | 108146 | 213282 | 64177238 |
Abdominal discomfort | 178.84 | 14.05 | 43 | 108169 | 182279 | 64208241 |
Overdose | 176.76 | 14.05 | 28 | 108184 | 159538 | 64230982 |
Respiratory failure | 176.39 | 14.05 | 633 | 107579 | 160550 | 64229970 |
Drug abuse | 175.28 | 14.05 | 12 | 108200 | 132362 | 64258158 |
Musculoskeletal stiffness | 172.88 | 14.05 | 8 | 108204 | 123198 | 64267322 |
Secondary immunodeficiency | 170.99 | 14.05 | 86 | 108126 | 2638 | 64387882 |
Rash | 170.45 | 14.05 | 319 | 107893 | 458230 | 63932290 |
Arthropathy | 169.26 | 14.05 | 8 | 108204 | 120959 | 64269561 |
Bacterial infection | 169.06 | 14.05 | 209 | 108003 | 24741 | 64365779 |
Injection site pain | 167.69 | 14.05 | 4 | 108208 | 111404 | 64279116 |
Drug resistance | 167.61 | 14.05 | 248 | 107964 | 34854 | 64355666 |
Diffuse large B-cell lymphoma refractory | 167.01 | 14.05 | 65 | 108147 | 1059 | 64389461 |
Disease recurrence | 153.88 | 14.05 | 225 | 107987 | 31285 | 64359235 |
Neurotoxicity | 152.05 | 14.05 | 208 | 108004 | 27196 | 64363324 |
Pain in extremity | 151.67 | 14.05 | 171 | 108041 | 302914 | 64087606 |
Ototoxicity | 150.77 | 14.05 | 79 | 108133 | 2644 | 64387876 |
Anxiety | 148.96 | 14.05 | 77 | 108135 | 202572 | 64187948 |
Blood pressure increased | 145.08 | 14.05 | 54 | 108158 | 172498 | 64218022 |
Clostridium difficile colitis | 141.15 | 14.05 | 200 | 108012 | 27023 | 64363497 |
Cytomegalovirus chorioretinitis | 140.66 | 14.05 | 93 | 108119 | 4819 | 64385701 |
Human herpesvirus 6 infection | 140.31 | 14.05 | 91 | 108121 | 4563 | 64385957 |
Colitis | 139.69 | 14.05 | 306 | 107906 | 58368 | 64332152 |
Swelling | 138.34 | 14.05 | 48 | 108164 | 160170 | 64230350 |
Teratoma | 137.75 | 14.05 | 35 | 108177 | 116 | 64390404 |
Nephropathy toxic | 137.24 | 14.05 | 158 | 108054 | 17356 | 64373164 |
Fungal infection | 136.98 | 14.05 | 223 | 107989 | 34028 | 64356492 |
Graft versus host disease | 133.24 | 14.05 | 139 | 108073 | 13674 | 64376846 |
Neoplasm recurrence | 132.51 | 14.05 | 81 | 108131 | 3658 | 64386862 |
White blood cell count decreased | 131.45 | 14.05 | 569 | 107643 | 157268 | 64233252 |
Candida infection | 130.34 | 14.05 | 208 | 108004 | 31211 | 64359309 |
Renal salt-wasting syndrome | 126.29 | 14.05 | 42 | 108170 | 422 | 64390098 |
Enterococcal infection | 125.70 | 14.05 | 135 | 108077 | 13731 | 64376789 |
BK virus infection | 125.12 | 14.05 | 102 | 108110 | 7310 | 64383210 |
Cytomegalovirus viraemia | 122.88 | 14.05 | 119 | 108093 | 10709 | 64379811 |
Lymphopenia | 120.66 | 14.05 | 180 | 108032 | 25477 | 64365043 |
Hepatitis B reactivation | 119.65 | 14.05 | 84 | 108128 | 4805 | 64385715 |
Asthma | 119.43 | 14.05 | 11 | 108201 | 95214 | 64295306 |
Feeling abnormal | 117.11 | 14.05 | 39 | 108173 | 133563 | 64256957 |
Neuropathy peripheral | 116.32 | 14.05 | 447 | 107765 | 117078 | 64273442 |
Muscle spasms | 115.43 | 14.05 | 46 | 108166 | 140977 | 64249543 |
Sweat gland tumour | 114.73 | 14.05 | 40 | 108172 | 469 | 64390051 |
Pneumocystis jirovecii pneumonia | 111.97 | 14.05 | 181 | 108031 | 27453 | 64363067 |
Staphylococcal bacteraemia | 110.43 | 14.05 | 110 | 108102 | 10245 | 64380275 |
Mycobacterium chelonae infection | 109.84 | 14.05 | 59 | 108153 | 2078 | 64388442 |
Contraindicated product administered | 106.54 | 14.05 | 25 | 108187 | 107804 | 64282716 |
Ovarian germ cell teratoma | 106.45 | 14.05 | 25 | 108187 | 53 | 64390467 |
Renal tubular disorder | 104.47 | 14.05 | 84 | 108128 | 5903 | 64384617 |
Primary hypogonadism | 104.16 | 14.05 | 29 | 108183 | 148 | 64390372 |
Wound | 104.00 | 14.05 | 6 | 108206 | 76471 | 64314049 |
Contusion | 103.92 | 14.05 | 31 | 108181 | 113934 | 64276586 |
Epstein-Barr virus infection | 103.51 | 14.05 | 116 | 108096 | 12372 | 64378148 |
Acute promyelocytic leukaemia | 102.62 | 14.05 | 49 | 108163 | 1339 | 64389181 |
Urticaria | 102.38 | 14.05 | 60 | 108152 | 147257 | 64243263 |
Thrombotic microangiopathy | 100.94 | 14.05 | 132 | 108080 | 16523 | 64373997 |
Inappropriate schedule of product administration | 100.36 | 14.05 | 17 | 108195 | 92269 | 64298251 |
Progressive multifocal leukoencephalopathy | 96.07 | 14.05 | 135 | 108077 | 18097 | 64372423 |
Pseudomonal sepsis | 95.46 | 14.05 | 75 | 108137 | 5097 | 64385423 |
Parainfluenzae virus infection | 94.56 | 14.05 | 72 | 108140 | 4671 | 64385849 |
Suicidal ideation | 94.38 | 14.05 | 4 | 108208 | 66538 | 64323982 |
Stomatitis | 93.41 | 14.05 | 398 | 107814 | 109207 | 64281313 |
Depression | 93.15 | 14.05 | 102 | 108110 | 183189 | 64207331 |
Chronic graft versus host disease | 92.78 | 14.05 | 80 | 108132 | 6196 | 64384324 |
Therapeutic product effect decreased | 92.17 | 14.05 | 39 | 108173 | 115312 | 64275208 |
Arthritis | 92.12 | 14.05 | 15 | 108197 | 83799 | 64306721 |
Somnolence | 91.19 | 14.05 | 125 | 108087 | 203520 | 64187000 |
Injection site erythema | 89.26 | 14.05 | 8 | 108204 | 70792 | 64319728 |
Pulmonary haemorrhage | 89.10 | 14.05 | 110 | 108102 | 12999 | 64377521 |
Osteosarcoma | 88.50 | 14.05 | 29 | 108183 | 277 | 64390243 |
Bronchitis | 88.12 | 14.05 | 36 | 108176 | 108707 | 64281813 |
Stress | 88.04 | 14.05 | 3 | 108209 | 60531 | 64329989 |
Klebsiella sepsis | 85.63 | 14.05 | 54 | 108158 | 2578 | 64387942 |
Discomfort | 85.55 | 14.05 | 16 | 108196 | 80862 | 64309658 |
Chloroma | 84.75 | 14.05 | 35 | 108177 | 670 | 64389850 |
Oedema peripheral | 84.58 | 14.05 | 139 | 108073 | 210178 | 64180342 |
Hepatitis B | 83.93 | 14.05 | 83 | 108129 | 7662 | 64382858 |
Psoriasis | 83.04 | 14.05 | 11 | 108201 | 71692 | 64318828 |
Drug interaction | 82.75 | 14.05 | 320 | 107892 | 361763 | 64028757 |
Tremor | 82.73 | 14.05 | 76 | 108136 | 148154 | 64242366 |
Acute respiratory distress syndrome | 81.49 | 14.05 | 193 | 108019 | 38742 | 64351778 |
Oesophagitis | 81.33 | 14.05 | 137 | 108075 | 21493 | 64369027 |
Adenovirus infection | 80.95 | 14.05 | 79 | 108133 | 7176 | 64383344 |
Myalgia | 80.88 | 14.05 | 88 | 108124 | 158529 | 64231991 |
Anaplastic lymphoma kinase gene mutation | 80.75 | 14.05 | 22 | 108190 | 102 | 64390418 |
Pulmonary toxicity | 80.52 | 14.05 | 85 | 108127 | 8476 | 64382044 |
Influenza like illness | 80.48 | 14.05 | 6 | 108206 | 61696 | 64328824 |
Teratoma benign | 79.97 | 14.05 | 20 | 108192 | 61 | 64390459 |
Urinary tract infection | 79.92 | 14.05 | 168 | 108044 | 231428 | 64159092 |
Gait disturbance | 79.79 | 14.05 | 103 | 108109 | 172052 | 64218468 |
Epstein-Barr virus associated lymphoproliferative disorder | 79.63 | 14.05 | 55 | 108157 | 3064 | 64387456 |
Loss of personal independence in daily activities | 79.55 | 14.05 | 13 | 108199 | 72441 | 64318079 |
Suicide attempt | 77.39 | 14.05 | 13 | 108199 | 70994 | 64319526 |
Acute graft versus host disease in skin | 77.15 | 14.05 | 75 | 108137 | 6780 | 64383740 |
Peripheral sensory neuropathy | 76.57 | 14.05 | 95 | 108117 | 11283 | 64379237 |
Disseminated intravascular coagulation | 76.17 | 14.05 | 168 | 108044 | 32180 | 64358340 |
Oesophageal candidiasis | 76.11 | 14.05 | 80 | 108132 | 7937 | 64382583 |
Drug intolerance | 75.81 | 14.05 | 124 | 108088 | 187868 | 64202652 |
Alveolar soft part sarcoma | 75.79 | 14.05 | 20 | 108192 | 80 | 64390440 |
Klebsiella infection | 75.47 | 14.05 | 102 | 108110 | 13179 | 64377341 |
Diffuse large B-cell lymphoma | 75.40 | 14.05 | 90 | 108122 | 10271 | 64380249 |
Weight decreased | 75.01 | 14.05 | 238 | 107974 | 285501 | 64105019 |
Systemic candida | 74.89 | 14.05 | 66 | 108146 | 5263 | 64385257 |
Fungaemia | 74.45 | 14.05 | 57 | 108155 | 3728 | 64386792 |
Blood pressure fluctuation | 73.96 | 14.05 | 3 | 108209 | 51868 | 64338652 |
Bacterial sepsis | 73.64 | 14.05 | 76 | 108136 | 7381 | 64383139 |
Gene mutation | 73.52 | 14.05 | 45 | 108167 | 2037 | 64388483 |
Acute lymphocytic leukaemia | 71.37 | 14.05 | 59 | 108153 | 4312 | 64386208 |
Enterococcal bacteraemia | 70.69 | 14.05 | 47 | 108165 | 2458 | 64388062 |
Recurrent cancer | 70.55 | 14.05 | 46 | 108166 | 2327 | 64388193 |
Chest pain | 70.36 | 14.05 | 185 | 108027 | 235795 | 64154725 |
Capillary leak syndrome | 70.06 | 14.05 | 52 | 108160 | 3245 | 64387275 |
Abdominal pain upper | 70.06 | 14.05 | 116 | 108096 | 174914 | 64215606 |
Blood glucose increased | 69.47 | 14.05 | 39 | 108173 | 98034 | 64292486 |
Migraine | 69.36 | 14.05 | 11 | 108201 | 62666 | 64327854 |
Pulmonary vascular disorder | 69.30 | 14.05 | 33 | 108179 | 896 | 64389624 |
Hypoglycaemia | 69.27 | 14.05 | 32 | 108180 | 89860 | 64300660 |
Injury | 68.80 | 14.05 | 7 | 108205 | 55985 | 64334535 |
Hospitalisation | 67.57 | 14.05 | 21 | 108191 | 75186 | 64315334 |
Human bocavirus infection | 67.47 | 14.05 | 28 | 108184 | 543 | 64389977 |
Leukaemia recurrent | 66.83 | 14.05 | 46 | 108166 | 2548 | 64387972 |
Incorrect dose administered | 66.49 | 14.05 | 11 | 108201 | 60754 | 64329766 |
Myeloid leukaemia | 65.77 | 14.05 | 28 | 108184 | 580 | 64389940 |
Hypersensitivity | 65.69 | 14.05 | 145 | 108067 | 196307 | 64194213 |
Leukoencephalopathy | 65.21 | 14.05 | 69 | 108143 | 6898 | 64383622 |
Graft versus host disease in skin | 64.91 | 14.05 | 61 | 108151 | 5286 | 64385234 |
Complications of bone marrow transplant | 64.60 | 14.05 | 28 | 108184 | 607 | 64389913 |
Streptococcal bacteraemia | 64.34 | 14.05 | 48 | 108164 | 3019 | 64387501 |
Systemic mycosis | 64.14 | 14.05 | 43 | 108169 | 2280 | 64388240 |
Metastasis | 63.51 | 14.05 | 62 | 108150 | 5633 | 64384887 |
Refractory anaemia with an excess of blasts | 62.95 | 14.05 | 30 | 108182 | 816 | 64389704 |
Acute lymphocytic leukaemia recurrent | 62.95 | 14.05 | 53 | 108159 | 3973 | 64386547 |
Staphylococcal infection | 62.28 | 14.05 | 207 | 108005 | 50471 | 64340049 |
Memory impairment | 62.25 | 14.05 | 33 | 108179 | 85649 | 64304871 |
Pneumonitis | 62.14 | 14.05 | 206 | 108006 | 50159 | 64340361 |
Pleural effusion | 62.06 | 14.05 | 394 | 107818 | 126165 | 64264355 |
Dyspnoea | 62.02 | 14.05 | 842 | 107370 | 717832 | 63672688 |
Ovarian failure | 61.96 | 14.05 | 26 | 108186 | 519 | 64390001 |
Aplastic anaemia | 61.67 | 14.05 | 95 | 108117 | 13825 | 64376695 |
Post transplant lymphoproliferative disorder | 61.53 | 14.05 | 78 | 108134 | 9466 | 64381054 |
Herpes simplex | 61.52 | 14.05 | 82 | 108130 | 10454 | 64380066 |
Enteritis | 61.52 | 14.05 | 88 | 108124 | 11989 | 64378531 |
Vision blurred | 61.03 | 14.05 | 38 | 108174 | 90278 | 64300242 |
Hepatic enzyme increased | 60.97 | 14.05 | 77 | 108135 | 129866 | 64260654 |
Myocardial infarction | 60.85 | 14.05 | 116 | 108096 | 165705 | 64224815 |
Fusarium infection | 60.80 | 14.05 | 36 | 108176 | 1533 | 64388987 |
Hepatosplenic T-cell lymphoma | 60.71 | 14.05 | 29 | 108183 | 793 | 64389727 |
Mucormycosis | 60.51 | 14.05 | 68 | 108144 | 7273 | 64383247 |
Pneumothorax | 60.41 | 14.05 | 129 | 108083 | 24169 | 64366351 |
Glossodynia | 60.07 | 14.05 | 17 | 108195 | 64679 | 64325841 |
Agranulocytosis | 59.90 | 14.05 | 170 | 108042 | 38059 | 64352461 |
Back pain | 59.76 | 14.05 | 217 | 107995 | 249954 | 64140566 |
Coronary artery disease | 59.71 | 14.05 | 14 | 108198 | 60419 | 64330101 |
Cardiac failure congestive | 59.59 | 14.05 | 79 | 108133 | 130501 | 64260019 |
Musculoskeletal pain | 59.51 | 14.05 | 31 | 108181 | 81263 | 64309257 |
Salivary gland cancer | 59.02 | 14.05 | 23 | 108189 | 376 | 64390144 |
Nasal congestion | 58.59 | 14.05 | 14 | 108198 | 59644 | 64330876 |
Hypokalaemia | 58.22 | 14.05 | 377 | 107835 | 121526 | 64268994 |
Condition aggravated | 57.64 | 14.05 | 377 | 107835 | 372049 | 64018471 |
Lymphadenopathy | 57.64 | 14.05 | 191 | 108021 | 46495 | 64344025 |
Viral haemorrhagic cystitis | 56.87 | 14.05 | 35 | 108177 | 1600 | 64388920 |
Pneumonia klebsiella | 56.74 | 14.05 | 50 | 108162 | 3987 | 64386533 |
Palpitations | 56.62 | 14.05 | 55 | 108157 | 104433 | 64286087 |
Depressed mood | 56.43 | 14.05 | 3 | 108209 | 41009 | 64349511 |
Blood pressure systolic increased | 56.28 | 14.05 | 8 | 108204 | 49445 | 64341075 |
Hyperkalaemia | 56.24 | 14.05 | 52 | 108160 | 101077 | 64289443 |
Superior vena cava syndrome | 56.15 | 14.05 | 30 | 108182 | 1045 | 64389475 |
Pulmonary arteriopathy | 55.88 | 14.05 | 16 | 108196 | 92 | 64390428 |
Thymus hypoplasia | 55.85 | 14.05 | 24 | 108188 | 509 | 64390011 |
Balance disorder | 55.76 | 14.05 | 36 | 108176 | 83890 | 64306630 |
Hyperhidrosis | 55.56 | 14.05 | 77 | 108135 | 124843 | 64265677 |
Hypogammaglobulinaemia | 55.36 | 14.05 | 77 | 108135 | 10222 | 64380298 |
Acute myeloid leukaemia recurrent | 54.92 | 14.05 | 42 | 108170 | 2742 | 64387778 |
Blood cholesterol increased | 54.92 | 14.05 | 9 | 108203 | 50057 | 64340463 |
B-cell lymphoma recurrent | 54.38 | 14.05 | 27 | 108185 | 805 | 64389715 |
Ameloblastoma | 53.49 | 14.05 | 15 | 108197 | 79 | 64390441 |
Loss of consciousness | 53.38 | 14.05 | 105 | 108107 | 148260 | 64242260 |
Wheezing | 52.94 | 14.05 | 35 | 108177 | 80544 | 64309976 |
Sinusitis | 52.74 | 14.05 | 103 | 108109 | 145825 | 64244695 |
Blood stem cell transplant failure | 52.50 | 14.05 | 23 | 108189 | 512 | 64390008 |
Rhabdomyolysis | 52.40 | 14.05 | 46 | 108166 | 91680 | 64298840 |
Enterobacter infection | 52.39 | 14.05 | 46 | 108166 | 3650 | 64386870 |
Cardiomyopathy | 52.30 | 14.05 | 125 | 108087 | 25231 | 64365289 |
Premature menopause | 52.13 | 14.05 | 23 | 108189 | 521 | 64389999 |
Pneumonia fungal | 51.70 | 14.05 | 69 | 108143 | 8808 | 64381712 |
Psoriatic arthropathy | 51.67 | 14.05 | 6 | 108206 | 43275 | 64347245 |
Cerebrovascular accident | 51.57 | 14.05 | 95 | 108117 | 137488 | 64253032 |
Injection site pruritus | 51.32 | 14.05 | 3 | 108209 | 37823 | 64352697 |
Sleep disorder | 51.31 | 14.05 | 18 | 108194 | 59691 | 64330829 |
Metastases to lung | 51.28 | 14.05 | 92 | 108120 | 15172 | 64375348 |
Refractory cancer | 51.10 | 14.05 | 18 | 108194 | 218 | 64390302 |
Gastrooesophageal reflux disease | 50.84 | 14.05 | 39 | 108173 | 83104 | 64307416 |
Metastases to central nervous system | 50.83 | 14.05 | 87 | 108125 | 13825 | 64376695 |
Device related infection | 50.75 | 14.05 | 139 | 108073 | 30487 | 64360033 |
Dry mouth | 50.59 | 14.05 | 19 | 108193 | 60399 | 64330121 |
Paraneoplastic neurological syndrome | 50.51 | 14.05 | 13 | 108199 | 46 | 64390474 |
Varicella zoster virus infection | 50.38 | 14.05 | 46 | 108166 | 3842 | 64386678 |
Medulloblastoma recurrent | 50.37 | 14.05 | 15 | 108197 | 101 | 64390419 |
Gastrointestinal toxicity | 50.33 | 14.05 | 53 | 108159 | 5269 | 64385251 |
Mobility decreased | 50.31 | 14.05 | 42 | 108170 | 85798 | 64304722 |
Retinal haemorrhage | 50.15 | 14.05 | 62 | 108150 | 7336 | 64383184 |
Nephrolithiasis | 49.87 | 14.05 | 7 | 108205 | 43676 | 64346844 |
Trichosporon infection | 49.73 | 14.05 | 26 | 108186 | 866 | 64389654 |
Escherichia bacteraemia | 49.67 | 14.05 | 53 | 108159 | 5350 | 64385170 |
Blister | 49.48 | 14.05 | 38 | 108174 | 80929 | 64309591 |
Pneumatosis intestinalis | 49.32 | 14.05 | 52 | 108160 | 5177 | 64385343 |
T-cell type acute leukaemia | 49.29 | 14.05 | 16 | 108196 | 148 | 64390372 |
Chronic obstructive pulmonary disease | 49.25 | 14.05 | 29 | 108183 | 71019 | 64319501 |
Aortic thrombosis | 49.10 | 14.05 | 31 | 108181 | 1483 | 64389037 |
Deafness | 48.58 | 14.05 | 100 | 108112 | 18259 | 64372261 |
Rash pruritic | 48.15 | 14.05 | 18 | 108194 | 57386 | 64333134 |
Metastases to lymph nodes | 48.10 | 14.05 | 66 | 108146 | 8651 | 64381869 |
Pseudomonas infection | 48.02 | 14.05 | 98 | 108114 | 17785 | 64372735 |
Lymphoid tissue hypoplasia | 47.83 | 14.05 | 21 | 108191 | 470 | 64390050 |
Angioedema | 47.64 | 14.05 | 22 | 108190 | 61799 | 64328721 |
Impaired healing | 47.41 | 14.05 | 21 | 108191 | 60452 | 64330068 |
Large intestinal ulcer perforation | 47.08 | 14.05 | 13 | 108199 | 64 | 64390456 |
Therapy non-responder | 46.92 | 14.05 | 227 | 107985 | 65672 | 64324848 |
Osteonecrosis | 46.65 | 14.05 | 128 | 108084 | 28101 | 64362419 |
Hepatosplenomegaly | 46.64 | 14.05 | 51 | 108161 | 5292 | 64385228 |
Heart rate decreased | 46.64 | 14.05 | 17 | 108195 | 55050 | 64335470 |
Sedation | 46.51 | 14.05 | 7 | 108205 | 41455 | 64349065 |
Electrocardiogram QT prolonged | 46.40 | 14.05 | 39 | 108173 | 79409 | 64311111 |
Delayed puberty | 46.18 | 14.05 | 15 | 108197 | 139 | 64390381 |
Renal failure | 46.15 | 14.05 | 487 | 107725 | 181201 | 64209319 |
Myelopathy | 45.70 | 14.05 | 44 | 108168 | 3930 | 64386590 |
Vertigo | 45.47 | 14.05 | 21 | 108191 | 58990 | 64331530 |
Embolism | 45.34 | 14.05 | 77 | 108135 | 12158 | 64378362 |
Aggression | 45.10 | 14.05 | 11 | 108201 | 46221 | 64344299 |
Stenotrophomonas infection | 45.00 | 14.05 | 39 | 108173 | 3041 | 64387479 |
Mesenteric abscess | 44.59 | 14.05 | 14 | 108198 | 115 | 64390405 |
Wrong technique in product usage process | 44.36 | 14.05 | 27 | 108185 | 64947 | 64325573 |
Drug dependence | 44.13 | 14.05 | 3 | 108209 | 33309 | 64357211 |
Nail pigmentation | 43.23 | 14.05 | 17 | 108195 | 285 | 64390235 |
Subdural hygroma | 42.72 | 14.05 | 19 | 108193 | 439 | 64390081 |
Hypomagnesaemia | 42.70 | 14.05 | 149 | 108063 | 37227 | 64353293 |
Burning sensation | 42.63 | 14.05 | 15 | 108197 | 49649 | 64340871 |
Blood culture positive | 42.55 | 14.05 | 59 | 108153 | 7809 | 64382711 |
Gastrointestinal fungal infection | 42.41 | 14.05 | 18 | 108194 | 370 | 64390150 |
Toxic encephalopathy | 42.11 | 14.05 | 66 | 108146 | 9749 | 64380771 |
Leukaemia | 41.72 | 14.05 | 47 | 108165 | 5041 | 64385479 |
Metastases to bone marrow | 41.66 | 14.05 | 21 | 108191 | 647 | 64389873 |
Nervous system disorder | 41.53 | 14.05 | 108 | 108104 | 22970 | 64367550 |
Bicytopenia | 41.46 | 14.05 | 40 | 108172 | 3582 | 64386938 |
Ejection fraction decreased | 41.46 | 14.05 | 124 | 108088 | 28583 | 64361937 |
Encephalitis cytomegalovirus | 41.42 | 14.05 | 24 | 108188 | 981 | 64389539 |
Lactic acidosis | 41.26 | 14.05 | 26 | 108186 | 61384 | 64329136 |
Klebsiella bacteraemia | 41.18 | 14.05 | 33 | 108179 | 2307 | 64388213 |
Metastases to spleen | 40.91 | 14.05 | 19 | 108193 | 487 | 64390033 |
Diaphragm muscle weakness | 40.48 | 14.05 | 14 | 108198 | 160 | 64390360 |
Cytomegalovirus infection reactivation | 40.25 | 14.05 | 49 | 108163 | 5707 | 64384813 |
JC virus infection | 40.20 | 14.05 | 38 | 108174 | 3317 | 64387203 |
Myelitis | 39.76 | 14.05 | 31 | 108181 | 2083 | 64388437 |
Cardiomyopathy acute | 39.55 | 14.05 | 15 | 108197 | 227 | 64390293 |
Haematochezia | 39.48 | 14.05 | 32 | 108180 | 66341 | 64324179 |
Abscess bacterial | 39.08 | 14.05 | 21 | 108191 | 740 | 64389780 |
Rhabdomyosarcoma recurrent | 39.06 | 14.05 | 12 | 108200 | 91 | 64390429 |
Streptococcal infection | 38.83 | 14.05 | 55 | 108157 | 7424 | 64383096 |
Plasma cell leukaemia | 38.74 | 14.05 | 27 | 108185 | 1526 | 64388994 |
Influenza | 38.65 | 14.05 | 75 | 108137 | 106456 | 64284064 |
Adverse drug reaction | 38.56 | 14.05 | 14 | 108198 | 45450 | 64345070 |
Hypoaesthesia | 38.49 | 14.05 | 113 | 108099 | 138995 | 64251525 |
Cytokine release syndrome | 38.02 | 14.05 | 98 | 108114 | 20731 | 64369789 |
Hyperbilirubinaemia | 37.92 | 14.05 | 99 | 108113 | 21106 | 64369414 |
Blood creatine phosphokinase increased | 37.71 | 14.05 | 26 | 108186 | 58532 | 64331988 |
Road traffic accident | 37.37 | 14.05 | 4 | 108208 | 30741 | 64359779 |
Peripheral T-cell lymphoma unspecified | 37.32 | 14.05 | 19 | 108193 | 598 | 64389922 |
Flagellate dermatitis | 37.27 | 14.05 | 14 | 108198 | 206 | 64390314 |
Fanconi syndrome | 37.21 | 14.05 | 32 | 108180 | 2469 | 64388051 |
Acquired gene mutation | 37.08 | 14.05 | 29 | 108183 | 1957 | 64388563 |
Hepatotoxicity | 37.06 | 14.05 | 149 | 108063 | 39813 | 64350707 |
Serotonin syndrome | 37.06 | 14.05 | 10 | 108202 | 39272 | 64351248 |
Blood lactate dehydrogenase increased | 37.04 | 14.05 | 131 | 108081 | 32947 | 64357573 |
Pulmonary alveolar haemorrhage | 37.03 | 14.05 | 62 | 108150 | 9676 | 64380844 |
International normalised ratio increased | 37.03 | 14.05 | 47 | 108165 | 79120 | 64311400 |
Neuroblastoma | 37.01 | 14.05 | 13 | 108199 | 156 | 64390364 |
Clostridium colitis | 36.95 | 14.05 | 32 | 108180 | 2493 | 64388027 |
Acute myelomonocytic leukaemia | 36.92 | 14.05 | 15 | 108197 | 275 | 64390245 |
Viraemia | 36.88 | 14.05 | 31 | 108181 | 2318 | 64388202 |
Lung infiltration | 36.81 | 14.05 | 97 | 108115 | 20792 | 64369728 |
Swollen tongue | 36.78 | 14.05 | 7 | 108205 | 34947 | 64355573 |
Radiation pneumonitis | 36.68 | 14.05 | 36 | 108176 | 3292 | 64387228 |
Hallucination | 36.40 | 14.05 | 41 | 108171 | 72747 | 64317773 |
Respiratory distress | 36.35 | 14.05 | 179 | 108033 | 52152 | 64338368 |
Focal nodular hyperplasia | 36.20 | 14.05 | 19 | 108193 | 638 | 64389882 |
Extravasation | 36.18 | 14.05 | 35 | 108177 | 3145 | 64387375 |
Metastases to liver | 36.08 | 14.05 | 105 | 108107 | 23836 | 64366684 |
Osteonecrosis of jaw | 35.99 | 14.05 | 11 | 108201 | 39814 | 64350706 |
Radiation oesophagitis | 35.76 | 14.05 | 18 | 108194 | 553 | 64389967 |
Lower respiratory tract infection | 35.74 | 14.05 | 65 | 108147 | 94549 | 64295971 |
Ganglioneuroblastoma | 35.61 | 14.05 | 9 | 108203 | 29 | 64390491 |
Small cell lung cancer | 35.50 | 14.05 | 32 | 108180 | 2629 | 64387891 |
Fungal oesophagitis | 35.40 | 14.05 | 20 | 108192 | 779 | 64389741 |
Heart rate increased | 35.34 | 14.05 | 70 | 108142 | 98605 | 64291915 |
Therapy cessation | 35.28 | 14.05 | 6 | 108206 | 32483 | 64358037 |
Epstein Barr virus positive mucocutaneous ulcer | 35.14 | 14.05 | 19 | 108193 | 678 | 64389842 |
Vena cava thrombosis | 35.08 | 14.05 | 31 | 108181 | 2481 | 64388039 |
Staphylococcal sepsis | 35.01 | 14.05 | 71 | 108141 | 12828 | 64377692 |
Diabetes mellitus | 34.85 | 14.05 | 36 | 108176 | 66438 | 64324082 |
Venous thrombosis | 34.73 | 14.05 | 48 | 108164 | 6333 | 64384187 |
Encephalitis viral | 34.50 | 14.05 | 30 | 108182 | 2350 | 64388170 |
Amnesia | 34.45 | 14.05 | 19 | 108193 | 48250 | 64342270 |
Chronic myeloid leukaemia | 34.43 | 14.05 | 35 | 108177 | 3339 | 64387181 |
Skin candida | 34.27 | 14.05 | 26 | 108186 | 1677 | 64388843 |
Engraftment syndrome | 34.13 | 14.05 | 22 | 108190 | 1091 | 64389429 |
Fluid retention | 33.91 | 14.05 | 30 | 108182 | 59576 | 64330944 |
Adrenocortical carcinoma | 33.88 | 14.05 | 10 | 108202 | 65 | 64390455 |
Traumatic lung injury | 33.62 | 14.05 | 29 | 108183 | 2247 | 64388273 |
Bone marrow transplant | 33.57 | 14.05 | 23 | 108189 | 1264 | 64389256 |
Femur fracture | 33.53 | 14.05 | 8 | 108204 | 34127 | 64356393 |
Exposure during pregnancy | 33.42 | 14.05 | 49 | 108163 | 77626 | 64312894 |
Cutaneous calcification | 33.39 | 14.05 | 11 | 108201 | 107 | 64390413 |
Retinopathy proliferative | 33.39 | 14.05 | 11 | 108201 | 107 | 64390413 |
Epstein-Barr virus infection reactivation | 33.20 | 14.05 | 22 | 108190 | 1144 | 64389376 |
Unevaluable event | 33.07 | 14.05 | 22 | 108190 | 50467 | 64340053 |
Necrotising gastritis | 32.76 | 14.05 | 10 | 108202 | 74 | 64390446 |
T-cell lymphoma | 32.69 | 14.05 | 22 | 108190 | 1174 | 64389346 |
Hepatic candidiasis | 32.53 | 14.05 | 10 | 108202 | 76 | 64390444 |
Peripheral motor neuropathy | 32.50 | 14.05 | 32 | 108180 | 2938 | 64387582 |
Emotional distress | 32.48 | 14.05 | 10 | 108202 | 36028 | 64354492 |
Respiratory arrest | 32.20 | 14.05 | 25 | 108187 | 52960 | 64337560 |
Faeces discoloured | 32.18 | 14.05 | 3 | 108209 | 25726 | 64364794 |
Graft versus host disease in liver | 32.06 | 14.05 | 24 | 108188 | 1517 | 64389003 |
Diffuse alveolar damage | 32.00 | 14.05 | 33 | 108179 | 3202 | 64387318 |
Eosinophilia | 31.83 | 14.05 | 12 | 108200 | 38064 | 64352456 |
Graft versus host disease in gastrointestinal tract | 31.73 | 14.05 | 43 | 108169 | 5569 | 64384951 |
Encephalitis | 31.54 | 14.05 | 67 | 108145 | 12504 | 64378016 |
Lower respiratory tract infection fungal | 31.53 | 14.05 | 19 | 108193 | 836 | 64389684 |
Cystitis bacterial | 31.48 | 14.05 | 15 | 108197 | 408 | 64390112 |
Enterocolitis | 31.26 | 14.05 | 65 | 108147 | 11953 | 64378567 |
Drug reaction with eosinophilia and systemic symptoms | 31.19 | 14.05 | 27 | 108185 | 54190 | 64336330 |
Recall phenomenon | 31.14 | 14.05 | 20 | 108192 | 986 | 64389534 |
Confusional state | 31.12 | 14.05 | 284 | 107928 | 260860 | 64129660 |
Azoospermia | 30.88 | 14.05 | 11 | 108201 | 138 | 64390382 |
Accidental overdose | 30.81 | 14.05 | 9 | 108203 | 33548 | 64356972 |
Choriocarcinoma | 30.69 | 14.05 | 9 | 108203 | 57 | 64390463 |
Encephalitis enteroviral | 30.59 | 14.05 | 11 | 108201 | 142 | 64390378 |
Pneumonia | 30.53 | 14.05 | 1187 | 107025 | 558389 | 63832131 |
Escherichia infection | 30.45 | 14.05 | 74 | 108138 | 15094 | 64375426 |
Nasal abscess | 30.25 | 14.05 | 11 | 108201 | 147 | 64390373 |
Retinal pigment epitheliopathy | 30.06 | 14.05 | 14 | 108198 | 361 | 64390159 |
Hypoalbuminaemia | 30.06 | 14.05 | 81 | 108131 | 17593 | 64372927 |
Paraesthesia | 29.94 | 14.05 | 120 | 108092 | 134402 | 64256118 |
Injection site haemorrhage | 29.91 | 14.05 | 3 | 108209 | 24275 | 64366245 |
Iris atrophy | 29.59 | 14.05 | 10 | 108202 | 106 | 64390414 |
Mantle cell lymphoma recurrent | 29.38 | 14.05 | 15 | 108197 | 475 | 64390045 |
Diabetic ketoacidosis | 29.31 | 14.05 | 7 | 108205 | 29838 | 64360682 |
Sopor | 29.04 | 14.05 | 7 | 108205 | 29654 | 64360866 |
Intestinal perforation | 28.94 | 14.05 | 73 | 108139 | 15240 | 64375280 |
Blood electrolytes abnormal | 28.88 | 14.05 | 24 | 108188 | 1767 | 64388753 |
Plasmacytoma | 28.79 | 14.05 | 34 | 108178 | 3836 | 64386684 |
Listeria sepsis | 28.75 | 14.05 | 16 | 108196 | 605 | 64389915 |
Metastases to muscle | 28.74 | 14.05 | 13 | 108199 | 313 | 64390207 |
Hypophosphataemia | 28.68 | 14.05 | 71 | 108141 | 14649 | 64375871 |
Leukoerythroblastosis | 28.48 | 14.05 | 12 | 108200 | 242 | 64390278 |
Metastases to diaphragm | 28.39 | 14.05 | 8 | 108204 | 43 | 64390477 |
Injection site reaction | 28.38 | 14.05 | 22 | 108190 | 46642 | 64343878 |
Neck pain | 28.29 | 14.05 | 37 | 108175 | 61496 | 64329024 |
Hepatic cirrhosis | 28.24 | 14.05 | 5 | 108207 | 26293 | 64364227 |
Disturbance in attention | 28.13 | 14.05 | 17 | 108195 | 41057 | 64349463 |
Blood glucose decreased | 28.12 | 14.05 | 3 | 108209 | 23120 | 64367400 |
Acne | 28.06 | 14.05 | 3 | 108209 | 23078 | 64367442 |
Head injury | 28.04 | 14.05 | 10 | 108202 | 32832 | 64357688 |
Toxicity to various agents | 28.03 | 14.05 | 435 | 107777 | 363078 | 64027442 |
Cardio-respiratory arrest | 27.89 | 14.05 | 79 | 108133 | 98314 | 64292206 |
Localised infection | 27.85 | 14.05 | 8 | 108204 | 30153 | 64360367 |
Geotrichum infection | 27.79 | 14.05 | 18 | 108194 | 900 | 64389620 |
Escherichia sepsis | 27.76 | 14.05 | 46 | 108166 | 7119 | 64383401 |
Norovirus test positive | 27.61 | 14.05 | 14 | 108198 | 437 | 64390083 |
Alpha haemolytic streptococcal infection | 27.57 | 14.05 | 23 | 108189 | 1702 | 64388818 |
Red blood cell sedimentation rate increased | 27.56 | 14.05 | 9 | 108203 | 31226 | 64359294 |
Underdose | 27.54 | 14.05 | 5 | 108207 | 25824 | 64364696 |
Papillary thyroid cancer | 27.48 | 14.05 | 26 | 108186 | 2272 | 64388248 |
Cellulitis gangrenous | 27.36 | 14.05 | 12 | 108200 | 268 | 64390252 |
Metastases to retroperitoneum | 27.06 | 14.05 | 13 | 108199 | 360 | 64390160 |
Flatulence | 27.00 | 14.05 | 13 | 108199 | 35653 | 64354867 |
Pneumonia aspiration | 26.88 | 14.05 | 36 | 108176 | 59235 | 64331285 |
Myelitis transverse | 26.69 | 14.05 | 22 | 108190 | 1601 | 64388919 |
Tumour hyperprogression | 26.63 | 14.05 | 10 | 108202 | 147 | 64390373 |
Infection | 26.60 | 14.05 | 447 | 107765 | 184433 | 64206087 |
Gliosis | 26.48 | 14.05 | 13 | 108199 | 378 | 64390142 |
Type 2 diabetes mellitus | 26.37 | 14.05 | 12 | 108200 | 34008 | 64356512 |
Splenomegaly | 26.33 | 14.05 | 78 | 108134 | 17883 | 64372637 |
Fungal sepsis | 26.28 | 14.05 | 22 | 108190 | 1636 | 64388884 |
Accidental exposure to product | 26.25 | 14.05 | 6 | 108206 | 26358 | 64364162 |
Li-Fraumeni syndrome | 26.12 | 14.05 | 6 | 108206 | 11 | 64390509 |
Odynophagia | 26.08 | 14.05 | 53 | 108159 | 9588 | 64380932 |
Lymphoma | 25.86 | 14.05 | 66 | 108146 | 13875 | 64376645 |
Abdominal distension | 25.81 | 14.05 | 79 | 108133 | 95915 | 64294605 |
Enterococcal sepsis | 25.68 | 14.05 | 26 | 108186 | 2468 | 64388052 |
Intestinal atresia | 25.67 | 14.05 | 8 | 108204 | 64 | 64390456 |
Cerebral salt-wasting syndrome | 25.55 | 14.05 | 9 | 108203 | 109 | 64390411 |
Central nervous system fungal infection | 25.54 | 14.05 | 13 | 108199 | 409 | 64390111 |
Cataract | 25.49 | 14.05 | 29 | 108183 | 51233 | 64339287 |
Genotoxicity | 25.43 | 14.05 | 7 | 108205 | 34 | 64390486 |
Transient ischaemic attack | 25.42 | 14.05 | 22 | 108190 | 44160 | 64346360 |
Hip fracture | 25.38 | 14.05 | 7 | 108205 | 27092 | 64363428 |
Hair follicle tumour benign | 25.17 | 14.05 | 13 | 108199 | 422 | 64390098 |
Diverticulitis | 25.06 | 14.05 | 17 | 108195 | 38601 | 64351919 |
Therapy responder | 25.00 | 14.05 | 13 | 108199 | 428 | 64390092 |
Device issue | 25.00 | 14.05 | 4 | 108208 | 22644 | 64367876 |
Dyspnoea exertional | 24.96 | 14.05 | 54 | 108158 | 73676 | 64316844 |
Respiratory tract infection fungal | 24.96 | 14.05 | 18 | 108194 | 1074 | 64389446 |
Electrolyte imbalance | 24.93 | 14.05 | 96 | 108116 | 25147 | 64365373 |
Streptococcal sepsis | 24.75 | 14.05 | 25 | 108187 | 2367 | 64388153 |
Bradycardia | 24.73 | 14.05 | 108 | 108104 | 118111 | 64272409 |
Carcinoid crisis | 24.65 | 14.05 | 13 | 108199 | 441 | 64390079 |
Dyspepsia | 24.64 | 14.05 | 62 | 108150 | 80250 | 64310270 |
Hypoxia | 24.62 | 14.05 | 241 | 107971 | 87908 | 64302612 |
Rhinovirus infection | 24.49 | 14.05 | 40 | 108172 | 6116 | 64384404 |
Abortion spontaneous | 24.49 | 14.05 | 6 | 108206 | 25137 | 64365383 |
Abnormal behaviour | 24.34 | 14.05 | 13 | 108199 | 33609 | 64356911 |
Ewing's sarcoma recurrent | 24.32 | 14.05 | 6 | 108206 | 17 | 64390503 |
Neutrophil count abnormal | 24.17 | 14.05 | 27 | 108185 | 2869 | 64387651 |
Carbamoyl phosphate synthetase deficiency | 24.07 | 14.05 | 6 | 108206 | 18 | 64390502 |
Medication error | 24.06 | 14.05 | 29 | 108183 | 49937 | 64340583 |
Amenorrhoea | 24.03 | 14.05 | 41 | 108171 | 6498 | 64384022 |
Ear infection | 23.97 | 14.05 | 5 | 108207 | 23399 | 64367121 |
Viral infection | 23.95 | 14.05 | 122 | 108090 | 36018 | 64354502 |
Clostridium bacteraemia | 23.79 | 14.05 | 11 | 108201 | 279 | 64390241 |
Chest discomfort | 23.73 | 14.05 | 107 | 108105 | 115999 | 64274521 |
Maternal exposure during pregnancy | 23.64 | 14.05 | 82 | 108130 | 95802 | 64294718 |
Hypoacusis | 23.63 | 14.05 | 96 | 108116 | 25771 | 64364749 |
Adverse event | 23.53 | 14.05 | 19 | 108193 | 39470 | 64351050 |
Coronavirus infection | 23.46 | 14.05 | 37 | 108175 | 5493 | 64385027 |
Treatment noncompliance | 23.41 | 14.05 | 23 | 108189 | 43459 | 64347061 |
Hyperlipidaemia | 23.34 | 14.05 | 5 | 108207 | 22971 | 64367549 |
Dry skin | 23.28 | 14.05 | 31 | 108181 | 51130 | 64339390 |
Osteosarcoma metastatic | 23.27 | 14.05 | 7 | 108205 | 49 | 64390471 |
Paraparesis | 23.18 | 14.05 | 29 | 108183 | 3473 | 64387047 |
Throat irritation | 23.17 | 14.05 | 13 | 108199 | 32698 | 64357822 |
Breast cancer | 23.04 | 14.05 | 10 | 108202 | 29138 | 64361382 |
Diabetes mellitus inadequate control | 23.01 | 14.05 | 4 | 108208 | 21317 | 64369203 |
Alopecia | 22.99 | 14.05 | 173 | 108039 | 165517 | 64225003 |
Human herpesvirus 8 infection | 22.97 | 14.05 | 17 | 108195 | 1056 | 64389464 |
Osteoporosis | 22.96 | 14.05 | 22 | 108190 | 42058 | 64348462 |
Hypertension | 22.87 | 14.05 | 302 | 107910 | 258959 | 64131561 |
Chromaturia | 22.81 | 14.05 | 5 | 108207 | 22606 | 64367914 |
Autoimmune neutropenia | 22.78 | 14.05 | 12 | 108200 | 406 | 64390114 |
Transdifferentiation of neoplasm | 22.78 | 14.05 | 8 | 108204 | 96 | 64390424 |
Scedosporium infection | 22.74 | 14.05 | 18 | 108194 | 1236 | 64389284 |
Folliculitis | 22.71 | 14.05 | 11 | 108201 | 30066 | 64360454 |
Fanconi syndrome acquired | 22.70 | 14.05 | 24 | 108188 | 2397 | 64388123 |
Pericarditis | 22.68 | 14.05 | 44 | 108168 | 62472 | 64328048 |
Arterial thrombosis | 22.62 | 14.05 | 24 | 108188 | 2406 | 64388114 |
Toxic neuropathy | 22.62 | 14.05 | 15 | 108197 | 781 | 64389739 |
Cerebral venous thrombosis | 22.53 | 14.05 | 24 | 108188 | 2417 | 64388103 |
Candida sepsis | 22.53 | 14.05 | 23 | 108189 | 2205 | 64388315 |
Disseminated aspergillosis | 22.47 | 14.05 | 14 | 108198 | 654 | 64389866 |
Skin toxicity | 22.44 | 14.05 | 40 | 108172 | 6562 | 64383958 |
Blood pressure diastolic decreased | 22.36 | 14.05 | 5 | 108207 | 22296 | 64368224 |
Pregnancy | 22.33 | 14.05 | 4 | 108208 | 20861 | 64369659 |
Mucocutaneous ulceration | 22.28 | 14.05 | 11 | 108201 | 324 | 64390196 |
Liver function test abnormal | 22.26 | 14.05 | 41 | 108171 | 59360 | 64331160 |
Eczema | 22.24 | 14.05 | 11 | 108201 | 29709 | 64360811 |
Dyskinesia | 22.19 | 14.05 | 20 | 108192 | 39368 | 64351152 |
Acute monocytic leukaemia | 22.12 | 14.05 | 12 | 108200 | 431 | 64390089 |
Mucosal infection | 22.07 | 14.05 | 12 | 108200 | 433 | 64390087 |
Sinus polyp | 21.80 | 14.05 | 12 | 108200 | 444 | 64390076 |
Iron deficiency anaemia | 21.76 | 14.05 | 5 | 108207 | 21884 | 64368636 |
Dysstasia | 21.73 | 14.05 | 6 | 108206 | 23209 | 64367311 |
Multiple sclerosis | 21.70 | 14.05 | 3 | 108209 | 18938 | 64371582 |
Basal cell naevus syndrome | 21.65 | 14.05 | 6 | 108206 | 30 | 64390490 |
Primitive neuroectodermal tumour | 21.49 | 14.05 | 6 | 108206 | 31 | 64390489 |
Hypertensive hydrocephalus | 21.48 | 14.05 | 5 | 108207 | 10 | 64390510 |
Gastroenteritis adenovirus | 21.43 | 14.05 | 10 | 108202 | 259 | 64390261 |
Metastases to meninges | 21.39 | 14.05 | 25 | 108187 | 2790 | 64387730 |
Cholelithiasis | 21.29 | 14.05 | 27 | 108185 | 45479 | 64345041 |
Disorder of orbit | 21.22 | 14.05 | 8 | 108204 | 119 | 64390401 |
Testicular malignant teratoma | 21.16 | 14.05 | 5 | 108207 | 11 | 64390509 |
Right ventricular failure | 21.15 | 14.05 | 5 | 108207 | 21466 | 64369054 |
Drug clearance decreased | 21.14 | 14.05 | 24 | 108188 | 2595 | 64387925 |
Therapy interrupted | 21.10 | 14.05 | 4 | 108208 | 20032 | 64370488 |
Epiphyses premature fusion | 21.08 | 14.05 | 7 | 108205 | 70 | 64390450 |
Hot flush | 21.05 | 14.05 | 28 | 108184 | 46207 | 64344313 |
Cerebellar tumour | 20.99 | 14.05 | 7 | 108205 | 71 | 64390449 |
Administration related reaction | 20.98 | 14.05 | 8 | 108204 | 123 | 64390397 |
Adenocarcinoma gastric | 20.92 | 14.05 | 19 | 108193 | 1576 | 64388944 |
Cerebellar haemangioma | 20.90 | 14.05 | 7 | 108205 | 72 | 64390448 |
Ileus | 20.79 | 14.05 | 85 | 108127 | 22881 | 64367639 |
Pneumomediastinum | 20.79 | 14.05 | 25 | 108187 | 2875 | 64387645 |
Bacterial tracheitis | 20.74 | 14.05 | 6 | 108206 | 36 | 64390484 |
Guillain-Barre syndrome | 20.69 | 14.05 | 42 | 108170 | 7593 | 64382927 |
Cardiac disorder | 20.50 | 14.05 | 39 | 108173 | 55777 | 64334743 |
Terminal ileitis | 20.49 | 14.05 | 13 | 108199 | 627 | 64389893 |
Autoimmune haemolytic anaemia | 20.46 | 14.05 | 40 | 108172 | 7036 | 64383484 |
Pain in jaw | 20.33 | 14.05 | 23 | 108189 | 40732 | 64349788 |
Haematopoietic stem cell mobilisation | 20.27 | 14.05 | 9 | 108203 | 207 | 64390313 |
Basal ganglion degeneration | 20.23 | 14.05 | 11 | 108201 | 397 | 64390123 |
Upper respiratory tract infection | 20.22 | 14.05 | 59 | 108153 | 72726 | 64317794 |
Agitation | 20.19 | 14.05 | 78 | 108134 | 88289 | 64302231 |
Small cell carcinoma | 20.15 | 14.05 | 10 | 108202 | 298 | 64390222 |
Acute lymphocytic leukaemia refractory | 20.13 | 14.05 | 8 | 108204 | 138 | 64390382 |
Sputum discoloured | 20.06 | 14.05 | 3 | 108209 | 17853 | 64372667 |
Gait inability | 19.97 | 14.05 | 25 | 108187 | 42343 | 64348177 |
Lymphoma transformation | 19.92 | 14.05 | 9 | 108203 | 216 | 64390304 |
Skin laceration | 19.90 | 14.05 | 8 | 108204 | 24409 | 64366111 |
Depressed level of consciousness | 19.84 | 14.05 | 70 | 108142 | 81366 | 64309154 |
Product administered to patient of inappropriate age | 19.82 | 14.05 | 31 | 108181 | 4570 | 64385950 |
Tumour necrosis | 19.80 | 14.05 | 19 | 108193 | 1690 | 64388830 |
Premature ageing | 19.78 | 14.05 | 7 | 108205 | 86 | 64390434 |
Respiratory syncytial virus infection | 19.72 | 14.05 | 40 | 108172 | 7228 | 64383292 |
Peripheral sensorimotor neuropathy | 19.71 | 14.05 | 23 | 108189 | 2562 | 64387958 |
Ocular vascular disorder | 19.69 | 14.05 | 11 | 108201 | 419 | 64390101 |
Pneumocystis jirovecii infection | 19.68 | 14.05 | 22 | 108190 | 2339 | 64388181 |
Central nervous system lymphoma | 19.61 | 14.05 | 20 | 108192 | 1915 | 64388605 |
Drug clearance increased | 19.51 | 14.05 | 9 | 108203 | 227 | 64390293 |
Full blood count abnormal | 19.44 | 14.05 | 13 | 108199 | 29744 | 64360776 |
Retinopathy | 19.36 | 14.05 | 26 | 108186 | 3339 | 64387181 |
Gallbladder empyema | 19.35 | 14.05 | 7 | 108205 | 92 | 64390428 |
Hepatic failure | 19.34 | 14.05 | 159 | 108053 | 55235 | 64335285 |
Visceral oedema | 19.15 | 14.05 | 5 | 108207 | 19 | 64390501 |
Ascites | 19.05 | 14.05 | 173 | 108039 | 61828 | 64328692 |
Epstein-Barr viraemia | 18.99 | 14.05 | 19 | 108193 | 1778 | 64388742 |
Hiatus hernia | 18.98 | 14.05 | 5 | 108207 | 19952 | 64370568 |
Enterobacter bacteraemia | 18.93 | 14.05 | 12 | 108200 | 578 | 64389942 |
Radiation injury | 18.87 | 14.05 | 13 | 108199 | 721 | 64389799 |
Platelet transfusion | 18.87 | 14.05 | 19 | 108193 | 1792 | 64388728 |
Tooth disorder | 18.82 | 14.05 | 7 | 108205 | 22395 | 64368125 |
Abdominal compartment syndrome | 18.71 | 14.05 | 17 | 108195 | 1411 | 64389109 |
Clostridial infection | 18.68 | 14.05 | 32 | 108180 | 5087 | 64385433 |
Withdrawal syndrome | 18.66 | 14.05 | 8 | 108204 | 23484 | 64367036 |
Lacrimation increased | 18.62 | 14.05 | 4 | 108208 | 18342 | 64372178 |
Blood urine present | 18.61 | 14.05 | 4 | 108208 | 18336 | 64372184 |
Vulvovaginal inflammation | 18.56 | 14.05 | 11 | 108201 | 469 | 64390051 |
Frequent bowel movements | 18.56 | 14.05 | 4 | 108208 | 18301 | 64372219 |
Engraft failure | 18.55 | 14.05 | 12 | 108200 | 599 | 64389921 |
Hepatic function abnormal | 18.53 | 14.05 | 177 | 108035 | 64136 | 64326384 |
Acanthamoeba infection | 18.44 | 14.05 | 11 | 108201 | 475 | 64390045 |
Peripheral artery thrombosis | 18.43 | 14.05 | 24 | 108188 | 2991 | 64387529 |
Atypical teratoid/rhabdoid tumour of CNS | 18.39 | 14.05 | 5 | 108207 | 23 | 64390497 |
Pneumonia cytomegaloviral | 18.37 | 14.05 | 29 | 108183 | 4310 | 64386210 |
Inflammatory pseudotumour | 18.34 | 14.05 | 6 | 108206 | 57 | 64390463 |
Mucosal toxicity | 18.31 | 14.05 | 11 | 108201 | 481 | 64390039 |
Neuroendocrine tumour of the lung metastatic | 18.27 | 14.05 | 7 | 108205 | 109 | 64390411 |
Inappropriate antidiuretic hormone secretion | 18.24 | 14.05 | 80 | 108132 | 22209 | 64368311 |
Sleep apnoea syndrome | 18.22 | 14.05 | 14 | 108198 | 29818 | 64360702 |
Ewing's sarcoma | 18.21 | 14.05 | 5 | 108207 | 24 | 64390496 |
Flushing | 18.19 | 14.05 | 207 | 108005 | 78441 | 64312079 |
Testicular germ cell cancer metastatic | 18.16 | 14.05 | 6 | 108206 | 59 | 64390461 |
Cardiac arrest | 18.13 | 14.05 | 168 | 108044 | 153896 | 64236624 |
Bone marrow infiltration | 18.11 | 14.05 | 11 | 108201 | 491 | 64390029 |
Colitis ulcerative | 18.04 | 14.05 | 8 | 108204 | 23020 | 64367500 |
Asthenia | 17.98 | 14.05 | 564 | 107648 | 427480 | 63963040 |
Lethargy | 17.95 | 14.05 | 62 | 108150 | 72532 | 64317988 |
Vulvovaginitis | 17.92 | 14.05 | 9 | 108203 | 275 | 64390245 |
Neurological decompensation | 17.89 | 14.05 | 29 | 108183 | 4407 | 64386113 |
Kidney infection | 17.88 | 14.05 | 4 | 108208 | 17834 | 64372686 |
Heart rate irregular | 17.87 | 14.05 | 12 | 108200 | 27401 | 64363119 |
Subdural haemorrhage | 17.86 | 14.05 | 32 | 108180 | 5271 | 64385249 |
Adenomatous polyposis coli | 17.82 | 14.05 | 8 | 108204 | 189 | 64390331 |
Glioblastoma multiforme | 17.76 | 14.05 | 15 | 108197 | 1129 | 64389391 |
Serum ferritin increased | 17.74 | 14.05 | 42 | 108170 | 8426 | 64382094 |
Blindness cortical | 17.67 | 14.05 | 13 | 108199 | 800 | 64389720 |
Hemianopia | 17.62 | 14.05 | 17 | 108195 | 1522 | 64388998 |
Stomatitis necrotising | 17.56 | 14.05 | 8 | 108204 | 196 | 64390324 |
Hepatic infection fungal | 17.56 | 14.05 | 8 | 108204 | 196 | 64390324 |
Neuroblastoma recurrent | 17.55 | 14.05 | 6 | 108206 | 66 | 64390454 |
B precursor type acute leukaemia | 17.49 | 14.05 | 9 | 108203 | 290 | 64390230 |
Skin discolouration | 17.47 | 14.05 | 20 | 108192 | 35235 | 64355285 |
Hepatorenal failure | 17.45 | 14.05 | 15 | 108197 | 1157 | 64389363 |
Pyomyositis | 17.37 | 14.05 | 11 | 108201 | 529 | 64389991 |
Mood swings | 17.34 | 14.05 | 4 | 108208 | 17464 | 64373056 |
Minimal residual disease | 17.30 | 14.05 | 10 | 108202 | 407 | 64390113 |
Viral hepatitis carrier | 17.28 | 14.05 | 5 | 108207 | 30 | 64390490 |
Fracture | 17.27 | 14.05 | 5 | 108207 | 18750 | 64371770 |
Dry eye | 17.24 | 14.05 | 14 | 108198 | 29005 | 64361515 |
Scrotal abscess | 17.21 | 14.05 | 10 | 108202 | 411 | 64390109 |
Atypical haemolytic uraemic syndrome | 17.19 | 14.05 | 12 | 108200 | 680 | 64389840 |
Procalcitonin decreased | 17.19 | 14.05 | 4 | 108208 | 8 | 64390512 |
Primary mediastinal large B-cell lymphoma recurrent | 17.16 | 14.05 | 6 | 108206 | 71 | 64390449 |
Human polyomavirus infection | 17.15 | 14.05 | 14 | 108198 | 1005 | 64389515 |
Rhinorrhoea | 17.10 | 14.05 | 48 | 108164 | 59921 | 64330599 |
Arteriosclerosis | 17.09 | 14.05 | 3 | 108209 | 15874 | 64374646 |
Renal tubular dysfunction | 17.07 | 14.05 | 12 | 108200 | 688 | 64389832 |
Transformation to acute myeloid leukaemia | 17.01 | 14.05 | 13 | 108199 | 848 | 64389672 |
Splenic infarction | 16.98 | 14.05 | 24 | 108188 | 3233 | 64387287 |
Blastic plasmacytoid dendritic cell neoplasia | 16.79 | 14.05 | 6 | 108206 | 76 | 64390444 |
Pulmonary veno-occlusive disease | 16.78 | 14.05 | 16 | 108196 | 1412 | 64389108 |
Retinal ischaemia | 16.76 | 14.05 | 12 | 108200 | 708 | 64389812 |
Pneumonia respiratory syncytial viral | 16.75 | 14.05 | 16 | 108196 | 1415 | 64389105 |
Clostridium test positive | 16.73 | 14.05 | 27 | 108185 | 4088 | 64386432 |
Spindle cell sarcoma | 16.67 | 14.05 | 8 | 108204 | 221 | 64390299 |
Aspiration bone marrow abnormal | 16.67 | 14.05 | 7 | 108205 | 140 | 64390380 |
Follicular thyroid cancer | 16.65 | 14.05 | 6 | 108206 | 78 | 64390442 |
Schistocytosis | 16.62 | 14.05 | 5 | 108207 | 35 | 64390485 |
Extrapyramidal disorder | 16.61 | 14.05 | 6 | 108206 | 19546 | 64370974 |
Pharyngeal oedema | 16.57 | 14.05 | 3 | 108209 | 15528 | 64374992 |
Hypertensive crisis | 16.56 | 14.05 | 5 | 108207 | 18243 | 64372277 |
Procedural pain | 16.54 | 14.05 | 3 | 108209 | 15505 | 64375015 |
Medulloblastoma | 16.51 | 14.05 | 6 | 108206 | 80 | 64390440 |
Ganglioneuroma | 16.49 | 14.05 | 7 | 108205 | 144 | 64390376 |
Vitreous haemorrhage | 16.48 | 14.05 | 23 | 108189 | 3062 | 64387458 |
Tissue infiltration | 16.43 | 14.05 | 11 | 108201 | 582 | 64389938 |
Cerebral fungal infection | 16.42 | 14.05 | 9 | 108203 | 330 | 64390190 |
Granulocyte count decreased | 16.35 | 14.05 | 15 | 108197 | 1261 | 64389259 |
Intussusception | 16.33 | 14.05 | 13 | 108199 | 900 | 64389620 |
Joint range of motion decreased | 16.33 | 14.05 | 6 | 108206 | 19337 | 64371183 |
CNS ventriculitis | 16.32 | 14.05 | 9 | 108203 | 334 | 64390186 |
Hydrocephalus | 16.28 | 14.05 | 38 | 108174 | 7553 | 64382967 |
Hepatitis D | 16.27 | 14.05 | 5 | 108207 | 38 | 64390482 |
Chronic myelomonocytic leukaemia | 16.25 | 14.05 | 12 | 108200 | 743 | 64389777 |
Coronary artery thrombosis | 16.25 | 14.05 | 22 | 108190 | 2847 | 64387673 |
Pneumocephalus | 16.16 | 14.05 | 8 | 108204 | 237 | 64390283 |
Sneezing | 16.16 | 14.05 | 3 | 108209 | 15248 | 64375272 |
Metastases to breast | 16.16 | 14.05 | 8 | 108204 | 237 | 64390283 |
Growth hormone deficiency | 16.13 | 14.05 | 9 | 108203 | 342 | 64390178 |
Meningitis tuberculous | 16.09 | 14.05 | 14 | 108198 | 1097 | 64389423 |
Musculoskeletal disorder | 16.08 | 14.05 | 5 | 108207 | 17901 | 64372619 |
Body temperature decreased | 16.05 | 14.05 | 12 | 108200 | 25916 | 64364604 |
Renal infarct | 16.01 | 14.05 | 20 | 108192 | 2391 | 64388129 |
Mucosal ulceration | 15.98 | 14.05 | 17 | 108195 | 1710 | 64388810 |
Uterine enlargement | 15.89 | 14.05 | 12 | 108200 | 769 | 64389751 |
Cold sweat | 15.88 | 14.05 | 4 | 108208 | 16451 | 64374069 |
Tonsillar haemorrhage | 15.86 | 14.05 | 8 | 108204 | 247 | 64390273 |
Neutropenic infection | 15.85 | 14.05 | 18 | 108194 | 1947 | 64388573 |
Feeling hot | 15.83 | 14.05 | 33 | 108179 | 45630 | 64344890 |
Retinal toxicity | 15.81 | 14.05 | 15 | 108197 | 1315 | 64389205 |
Papilloedema | 15.78 | 14.05 | 31 | 108181 | 5474 | 64385046 |
Dystonia | 15.68 | 14.05 | 6 | 108206 | 18859 | 64371661 |
Mania | 15.64 | 14.05 | 4 | 108208 | 16282 | 64374238 |
Musculoskeletal discomfort | 15.63 | 14.05 | 4 | 108208 | 16273 | 64374247 |
Brain sarcoma | 15.58 | 14.05 | 4 | 108208 | 14 | 64390506 |
Autologous bone marrow transplantation therapy | 15.58 | 14.05 | 4 | 108208 | 14 | 64390506 |
Bone sarcoma | 15.57 | 14.05 | 6 | 108206 | 95 | 64390425 |
Clostridium difficile infection | 15.54 | 14.05 | 109 | 108103 | 36054 | 64354466 |
Peripheral T-cell lymphoma unspecified recurrent | 15.43 | 14.05 | 5 | 108207 | 46 | 64390474 |
Appendicitis | 15.41 | 14.05 | 54 | 108158 | 13515 | 64377005 |
Nightmare | 15.37 | 14.05 | 8 | 108204 | 20985 | 64369535 |
Urinary bladder haematoma | 15.36 | 14.05 | 4 | 108208 | 15 | 64390505 |
Colony stimulating factor therapy | 15.35 | 14.05 | 10 | 108202 | 505 | 64390015 |
Restlessness | 15.32 | 14.05 | 27 | 108185 | 39758 | 64350762 |
Angina pectoris | 15.27 | 14.05 | 33 | 108179 | 45048 | 64345472 |
Platelet disorder | 15.23 | 14.05 | 19 | 108193 | 2268 | 64388252 |
Anti-platelet antibody positive | 15.18 | 14.05 | 8 | 108204 | 271 | 64390249 |
Subcutaneous emphysema | 15.17 | 14.05 | 16 | 108196 | 1593 | 64388927 |
Noctiphobia | 15.16 | 14.05 | 4 | 108208 | 16 | 64390504 |
Cerebral artery occlusion | 15.16 | 14.05 | 16 | 108196 | 1595 | 64388925 |
Pneumonia adenoviral | 15.12 | 14.05 | 7 | 108205 | 178 | 64390342 |
Central nervous system necrosis | 15.04 | 14.05 | 8 | 108204 | 276 | 64390244 |
Psychomotor hyperactivity | 14.98 | 14.05 | 3 | 108209 | 14448 | 64376072 |
Hepatomegaly | 14.90 | 14.05 | 62 | 108150 | 16820 | 64373700 |
Fusobacterium infection | 14.87 | 14.05 | 6 | 108206 | 108 | 64390412 |
Sarcoma | 14.84 | 14.05 | 11 | 108201 | 685 | 64389835 |
Hypoglossal nerve paresis | 14.82 | 14.05 | 6 | 108206 | 109 | 64390411 |
Idiopathic pneumonia syndrome | 14.77 | 14.05 | 10 | 108202 | 539 | 64389981 |
Gastrointestinal disorder | 14.77 | 14.05 | 89 | 108123 | 89620 | 64300900 |
Photosensitivity reaction | 14.74 | 14.05 | 6 | 108206 | 18167 | 64372353 |
B-cell lymphoma refractory | 14.72 | 14.05 | 6 | 108206 | 111 | 64390409 |
Bacillus bacteraemia | 14.72 | 14.05 | 6 | 108206 | 111 | 64390409 |
Pulmonary fibrosis | 14.61 | 14.05 | 93 | 108119 | 29785 | 64360735 |
VIth nerve paralysis | 14.58 | 14.05 | 15 | 108197 | 1451 | 64389069 |
Hepatic lesion | 14.56 | 14.05 | 31 | 108181 | 5793 | 64384727 |
Infected neoplasm | 14.56 | 14.05 | 8 | 108204 | 295 | 64390225 |
Human chorionic gonadotropin increased | 14.55 | 14.05 | 12 | 108200 | 874 | 64389646 |
Acute graft versus host disease in liver | 14.55 | 14.05 | 16 | 108196 | 1671 | 64388849 |
Prescribed underdose | 14.53 | 14.05 | 6 | 108206 | 18009 | 64372511 |
Myeloproliferative neoplasm | 14.51 | 14.05 | 12 | 108200 | 877 | 64389643 |
Rectal haemorrhage | 14.48 | 14.05 | 54 | 108158 | 61763 | 64328757 |
Testicular cancer metastatic | 14.47 | 14.05 | 5 | 108207 | 57 | 64390463 |
Opportunistic infection | 14.45 | 14.05 | 20 | 108192 | 2642 | 64387878 |
Thymus enlargement | 14.43 | 14.05 | 6 | 108206 | 117 | 64390403 |
Listeria encephalitis | 14.41 | 14.05 | 8 | 108204 | 301 | 64390219 |
Blast cell count increased | 14.40 | 14.05 | 14 | 108198 | 1265 | 64389255 |
Spinal cord infarction | 14.37 | 14.05 | 10 | 108202 | 564 | 64389956 |
Oesophageal fistula | 14.36 | 14.05 | 8 | 108204 | 303 | 64390217 |
Hyperadrenocorticism | 14.24 | 14.05 | 8 | 108204 | 308 | 64390212 |
Paraneoplastic syndrome | 14.23 | 14.05 | 12 | 108200 | 901 | 64389619 |
Crying | 14.20 | 14.05 | 8 | 108204 | 20082 | 64370438 |
Listeriosis | 14.15 | 14.05 | 17 | 108195 | 1953 | 64388567 |
Hodgkin's disease recurrent | 14.12 | 14.05 | 4 | 108208 | 22 | 64390498 |
Tooth hypoplasia | 14.06 | 14.05 | 7 | 108205 | 210 | 64390310 |
None
Source | Code | Description |
---|---|---|
ATC | L01CB01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Podophyllotoxin derivatives |
FDA MoA | N0000000176 | Topoisomerase Inhibitors |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:59517 | DNA synthesis inhibitors |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D000972 | Antineoplastic Agents, Phytogenic |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D059005 | Topoisomerase II Inhibitors |
FDA EPC | N0000175609 | Topoisomerase Inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Small cell carcinoma of lung | indication | 254632001 | DOID:5409 |
Malignant tumor of testis | indication | 363449006 | DOID:2998 |
Treatment prior to tumor-specific T-cell infusion therapy | indication | ||
Allogeneic bone marrow transplantation | off-label use | 58390007 | |
Ewing's sarcoma | off-label use | 76909002 | DOID:3369 |
Acute myeloid leukemia, disease | off-label use | 91861009 | |
Kaposi's sarcoma | off-label use | 109385007 | |
Diffuse non-Hodgkin's lymphoma, large cell | off-label use | 109969005 | |
Multiple myeloma | off-label use | 109989006 | DOID:9538 |
Hodgkin's disease | off-label use | 118599009 | |
Burkitt's lymphoma | off-label use | 118617000 | |
Non-small cell lung cancer | off-label use | 254637007 | DOID:3908 |
Osteosarcoma of bone | off-label use | 307576001 | DOID:3376 |
Malignant tumor of ovary | off-label use | 363443007 | DOID:2394 |
Neuroblastoma | off-label use | 432328008 | DOID:769 |
Ovarian Germ Cell Tumor Carcinoma | off-label use | ||
Neuroendocrine Prostate Carcinoma | off-label use | ||
Progressive Diffuse Large B-Cell Lymphoma | off-label use | ||
Testicular Germ Cell Tumor | off-label use | ||
Acute hemorrhage | contraindication | 8573003 | |
Fibrosis of lung | contraindication | 51615001 | DOID:3770 |
Metabolic acidosis | contraindication | 59455009 | |
Acute infectious disease | contraindication | 63171007 | |
Interstitial pneumonia | contraindication | 64667001 | |
Leukopenia | contraindication | 84828003 | DOID:615 |
Hypoalbuminemia | contraindication | 119247004 | |
Impaired renal function disorder | contraindication | 197663003 | |
Drug-induced hepatitis | contraindication | 235876009 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Breastfeeding (mother) | contraindication | 413712001 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.96 | acidic |
pKa2 | 13.08 | acidic |
pKa3 | 13.86 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase 2-alpha | Enzyme | INHIBITOR | IC50 | 7.30 | IUPHAR | CHEMBL | |||
Canalicular multispecific organic anion transporter 1 | Transporter | Km | 3.21 | WOMBAT-PK | |||||
Nuclear receptor subfamily 1 group I member 2 | Nuclear hormone receptor | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 1 | Transporter | WOMBAT-PK | |||||||
ATP-binding cassette sub-family G member 2 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 6 | Transporter | WOMBAT-PK | |||||||
Canalicular multispecific organic anion transporter 2 | Transporter | WOMBAT-PK | |||||||
DNA topoisomerase 2-beta | Enzyme | IC50 | 7.16 | CHEMBL | |||||
Multidrug resistance protein 1 | Transporter | Ki | 3.28 | WOMBAT-PK | |||||
Arachidonate 15-lipoxygenase | Enzyme | IC50 | 5.50 | DRUG MATRIX |
ID | Source |
---|---|
4018141 | VUID |
N0000146478 | NUI |
D00125 | KEGG_DRUG |
4018141 | VANDF |
C0015133 | UMLSCUI |
CHEBI:4911 | CHEBI |
EVP | PDB_CHEM_ID |
CHEMBL44657 | ChEMBL_ID |
D005047 | MESH_DESCRIPTOR_UI |
DB00773 | DRUGBANK_ID |
6815 | IUPHAR_LIGAND_ID |
3835 | INN_ID |
6PLQ3CP4P3 | UNII |
36462 | PUBCHEM_CID |
220347 | RXNORM |
4209 | MMSL |
4709 | MMSL |
6665 | MMSL |
d00230 | MMSL |
002674 | NDDF |
387316009 | SNOMEDCT_US |
56928005 | SNOMEDCT_US |
CHEMBL1200645 | ChEMBL_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9376 | INJECTION | 20 mg | INTRAVENOUS | ANDA | 22 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9510 | INJECTION | 20 mg | INTRAVENOUS | ANDA | 22 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9511 | INJECTION | 20 mg | INTRAVENOUS | ANDA | 22 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9512 | INJECTION | 20 mg | INTRAVENOUS | ANDA | 22 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3266 | CAPSULE | 50 mg | ORAL | ANDA | 24 sections |
Toposar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5653 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | ANDA | 24 sections |
Toposar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5656 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | ANDA | 24 sections |
Toposar | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-5657 | INJECTION, SOLUTION, CONCENTRATE | 20 mg | INTRAVENOUS | ANDA | 24 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-114 | INJECTION | 20 mg | INTRAVENOUS | ANDA | 22 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-104 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | ANDA | 14 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-104 | INJECTION, SOLUTION | 20 mg | INTRAVENOUS | ANDA | 14 sections |
Etoposide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-265 | INJECTION | 20 mg | INTRAVENOUS | ANDA | 22 sections |