etoposide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1112 33419-42-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • etoposide
  • etosid
  • fytosid
  • toposar
  • zuyeyidal
  • VP-16
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
  • Molecular weight: 588.56
  • Formula: C29H32O13
  • CLOGP: -0.11
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 3
  • TPSA: 160.83
  • ALOGS: -2.78
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.22 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 38 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 6.30 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 52 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.18 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 10, 1983 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 2147.52 15.50 1239 41945 93388 46549490
Neutropenia 915.84 15.50 875 42309 142329 46500549
Bone marrow failure 727.80 15.50 410 42774 29259 46613619
Mucosal inflammation 696.23 15.50 439 42745 38537 46604341
Pancytopenia 610.57 15.50 555 42629 84503 46558375
Acute myeloid leukaemia 607.38 15.50 295 42889 15483 46627395
Product use in unapproved indication 516.78 15.50 520 42664 89753 46553125
Haemophagocytic lymphohistiocytosis 478.79 15.50 206 42978 8136 46634742
Myelodysplastic syndrome 470.75 15.50 248 42936 15463 46627415
Thrombocytopenia 462.83 15.50 577 42607 126004 46516874
Haematotoxicity 403.77 15.50 173 43011 6760 46636118
Ovarian failure 398.52 15.50 109 43075 1023 46641855
Off label use 332.52 15.50 932 42252 378909 46263969
Sepsis 307.69 15.50 493 42691 135521 46507357
Febrile bone marrow aplasia 278.16 15.50 133 43051 6729 46636149
Second primary malignancy 271.12 15.50 129 43055 6455 46636423
Disease progression 264.98 15.50 372 42812 90928 46551950
Tumour lysis syndrome 239.01 15.50 122 43062 7114 46635764
Multiple organ dysfunction syndrome 228.54 15.50 260 42924 51450 46591428
Posterior reversible encephalopathy syndrome 227.05 15.50 153 43031 14988 46627890
Venoocclusive liver disease 221.18 15.50 98 43086 4153 46638725
Malignant neoplasm progression 216.33 15.50 283 42901 64643 46578235
Maternal exposure before pregnancy 203.65 15.50 94 43090 4387 46638491
Septic shock 201.70 15.50 258 42926 57635 46585243
Neutropenic sepsis 188.29 15.50 126 43058 12198 46630680
Diffuse large B-cell lymphoma refractory 185.08 15.50 58 43126 906 46641972
Pain 183.90 15.50 107 43077 476841 46166037
Arthralgia 181.63 15.50 56 43128 364547 46278331
Aplasia 181.43 15.50 81 43103 3495 46639383
Teratoma 175.08 15.50 39 43145 136 46642742
Encephalopathy 169.30 15.50 181 43003 33408 46609470
Myelosuppression 168.74 15.50 99 43085 7604 46635274
Ovarian germ cell teratoma 168.60 15.50 35 43149 78 46642800
Stem cell transplant 165.13 15.50 62 43122 1704 46641174
Fall 164.85 15.50 50 43134 329047 46313831
Pyrexia 163.37 15.50 696 42488 348106 46294772
Drug hypersensitivity 148.24 15.50 24 43160 243801 46399077
Hepatosplenic T-cell lymphoma 142.69 15.50 43 43141 585 46642293
Venoocclusive disease 141.50 15.50 57 43127 1899 46640979
Neutrophil count decreased 141.03 15.50 187 42997 43239 46599639
Cytomegalovirus infection 136.92 15.50 122 43062 18022 46624856
Joint swelling 135.28 15.50 4 43180 166069 46476809
Diffuse large B-cell lymphoma recurrent 130.90 15.50 50 43134 1442 46641436
Leukopenia 129.30 15.50 229 42955 68114 46574764
Headache 121.68 15.50 159 43025 478193 46164685
Disease recurrence 121.47 15.50 115 43069 18356 46624522
Drug resistance 119.72 15.50 111 43073 17257 46625621
Platelet count decreased 115.30 15.50 273 42911 99751 46543127
Neutropenic colitis 114.64 15.50 51 43133 2181 46640697
Nasopharyngitis 114.57 15.50 7 43177 153991 46488887
Product dose omission issue 113.35 15.50 12 43172 168508 46474370
Cardiotoxicity 113.07 15.50 73 43111 6649 46636229
Aspergillus infection 111.43 15.50 73 43111 6817 46636061
Bacteraemia 110.29 15.50 97 43087 14082 46628796
Peripheral swelling 109.60 15.50 10 43174 158061 46484817
Ototoxicity 109.01 15.50 40 43144 1029 46641849
Diffuse large B-cell lymphoma 98.68 15.50 64 43120 5874 46637004
Pain in extremity 98.05 15.50 59 43125 258621 46384257
Fatigue 97.10 15.50 268 42916 608429 46034449
Malignant transformation 95.58 15.50 27 43157 288 46642590
Acute graft versus host disease 94.11 15.50 54 43130 3976 46638902
Premature menopause 92.98 15.50 32 43152 679 46642199
Dizziness 92.89 15.50 107 43077 340307 46302571
Pruritus 92.23 15.50 55 43129 242297 46400581
Insomnia 92.12 15.50 20 43164 164904 46477974
Oesophagitis 91.68 15.50 86 43098 13565 46629313
Alveolar soft part sarcoma 91.61 15.50 21 43163 86 46642792
Osteosarcoma 89.60 15.50 22 43162 128 46642750
Malaise 89.42 15.50 105 43079 331127 46311751
Graft versus host disease 87.96 15.50 62 43122 6526 46636352
Neoplasm progression 86.75 15.50 115 43069 26568 46616310
Pulmonary haemorrhage 86.35 15.50 61 43123 6444 46636434
Primary hypogonadism 86.23 15.50 22 43162 153 46642725
Neurotoxicity 85.63 15.50 83 43101 13634 46629244
Enterococcal infection 82.43 15.50 61 43123 6926 46635952
Anaemia 82.35 15.50 459 42725 255320 46387558
Anxiety 81.75 15.50 33 43151 181924 46460954
Cystitis haemorrhagic 81.42 15.50 47 43137 3500 46639378
Abdominal discomfort 81.10 15.50 20 43164 151145 46491733
Weight increased 78.64 15.50 27 43157 164446 46478432
Acute lymphocytic leukaemia 78.00 15.50 42 43142 2731 46640147
Nephroblastoma 77.91 15.50 19 43165 107 46642771
Acute lymphocytic leukaemia recurrent 77.04 15.50 38 43146 2057 46640821
Injection site pain 76.39 15.50 6 43178 107146 46535732
Nephropathy toxic 74.59 15.50 59 43125 7395 46635483
Human herpesvirus 6 infection 74.42 15.50 39 43145 2400 46640478
Bronchopulmonary aspergillosis 74.29 15.50 59 43125 7437 46635441
Musculoskeletal stiffness 74.25 15.50 4 43180 97989 46544889
Colitis 72.99 15.50 127 43057 37220 46605658
Teratoma benign 72.45 15.50 16 43168 53 46642825
Complications of bone marrow transplant 69.25 15.50 23 43161 436 46642442
Cytomegalovirus viraemia 68.91 15.50 46 43138 4432 46638446
Asthma 68.54 15.50 4 43180 91538 46551340
Cytopenia 68.26 15.50 57 43127 7711 46635167
Retinoblastoma 66.91 15.50 17 43167 116 46642762
Rash 66.03 15.50 145 43039 356367 46286511
Urticaria 64.40 15.50 15 43169 117877 46525001
Fungaemia 64.09 15.50 33 43151 1958 46640920
Leukoencephalopathy 63.71 15.50 42 43142 3962 46638916
Gene mutation 63.02 15.50 27 43157 1053 46641825
Enterobacter infection 62.84 15.50 32 43152 1855 46641023
Muscle spasms 62.78 15.50 18 43166 123095 46519783
Capillary leak syndrome 62.68 15.50 32 43152 1865 46641013
White blood cell count decreased 61.01 15.50 235 42949 111996 46530882
Thrombotic microangiopathy 60.97 15.50 55 43129 8251 46634627
Clostridium difficile colitis 60.36 15.50 80 43104 18473 46624405
Acute promyelocytic leukaemia 60.34 15.50 25 43159 896 46641982
Epstein-Barr virus infection 60.07 15.50 50 43134 6734 46636144
Choriocarcinoma 59.21 15.50 15 43169 101 46642777
Feeling abnormal 58.95 15.50 21 43163 125039 46517839
Gait disturbance 58.03 15.50 31 43153 145232 46497646
Lymphopenia 57.73 15.50 71 43113 15222 46627656
Disseminated intravascular coagulation 57.34 15.50 79 43105 18926 46623952
Cervix disorder 56.97 15.50 20 43164 451 46642427
Overdose 55.64 15.50 13 43171 101966 46540912
BK virus infection 55.60 15.50 34 43150 2815 46640063
Drug intolerance 55.00 15.50 34 43150 147015 46495863
Bronchitis 54.95 15.50 15 43169 105964 46536914
Depression 54.92 15.50 46 43138 170058 46472820
Human bocavirus infection 54.91 15.50 18 43166 327 46642551
Candida infection 54.80 15.50 84 43100 22156 46620722
Large intestinal ulcer perforation 54.76 15.50 13 43171 64 46642814
Acute myeloid leukaemia recurrent 53.36 15.50 26 43158 1370 46641508
Arthropathy 52.15 15.50 8 43176 84692 46558186
JC virus infection 51.92 15.50 27 43157 1635 46641243
Myeloid leukaemia 51.60 15.50 17 43167 314 46642564
T-cell lymphoma 51.33 15.50 20 43164 609 46642269
Graft versus host disease in skin 50.73 15.50 30 43154 2337 46640541
Neoplasm recurrence 50.65 15.50 30 43154 2343 46640535
Secondary immunodeficiency 48.92 15.50 22 43162 965 46641913
Progressive multifocal leukoencephalopathy 48.29 15.50 56 43128 11290 46631588
Injection site erythema 48.25 15.50 6 43178 74421 46568457
Deafness 47.29 15.50 66 43118 16002 46626876
Systemic candida 46.81 15.50 30 43154 2697 46640181
Hospitalisation 46.75 15.50 3 43181 63382 46579496
Myalgia 46.66 15.50 28 43156 123060 46519818
Leukaemia 46.30 15.50 32 43152 3263 46639615
Post transplant lymphoproliferative disorder 46.24 15.50 34 43150 3822 46639056
Pleural effusion 46.13 15.50 175 43009 82777 46560101
Epstein-Barr virus associated lymphoproliferative disorder 46.13 15.50 24 43160 1455 46641423
Acute respiratory distress syndrome 46.06 15.50 77 43107 21845 46621033
Abdominal pain upper 46.03 15.50 40 43144 145265 46497613
Herpes simplex 45.63 15.50 44 43140 7179 46635699
Klebsiella sepsis 45.60 15.50 23 43161 1306 46641572
Renal tubular disorder 44.51 15.50 28 43156 2437 46640441
Acute graft versus host disease in skin 44.36 15.50 30 43154 2952 46639926
Drug abuse 43.95 15.50 4 43180 63404 46579474
Encephalitis viral 43.93 15.50 24 43160 1606 46641272
Arthritis 43.91 15.50 9 43175 77307 46565571
Blood culture positive 43.62 15.50 35 43149 4477 46638401
Adenovirus infection 43.37 15.50 29 43155 2801 46640077
Refractory anaemia with an excess of blasts 43.33 15.50 16 43168 419 46642459
Varicella zoster virus infection 43.28 15.50 27 43157 2316 46640562
Amenorrhoea 43.15 15.50 47 43137 8848 46634030
Leukaemia recurrent 43.01 15.50 22 43162 1287 46641591
Mesenteric abscess 42.45 15.50 11 43173 82 46642796
Ascites 42.24 15.50 100 43084 36484 46606394
Migraine 42.24 15.50 7 43177 70019 46572859
Superior vena cava syndrome 42.15 15.50 17 43167 568 46642310
Neuropathy peripheral 41.97 15.50 181 43003 90712 46552166
Renal salt-wasting syndrome 41.97 15.50 13 43171 195 46642683
Cutaneous calcification 41.55 15.50 11 43173 90 46642788
Blood pressure increased 41.18 15.50 34 43150 126632 46516246
Dyspnoea 41.07 15.50 294 42890 515254 46127624
Suicidal ideation 40.61 15.50 3 43181 56379 46586499
Encephalitis cytomegalovirus 40.50 15.50 16 43168 506 46642372
Hypokalaemia 40.42 15.50 175 43009 87849 46555029
Hypersensitivity 40.09 15.50 48 43136 150273 46492605
Hepatitis B reactivation 40.00 15.50 22 43162 1492 46641386
Memory impairment 39.98 15.50 11 43173 77326 46565552
Infection 39.77 15.50 235 42949 133357 46509521
Sweat gland tumour 39.76 15.50 11 43173 108 46642770
T-cell type acute leukaemia 39.65 15.50 10 43174 66 46642812
Pneumonia fungal 39.64 15.50 32 43152 4128 46638750
Stomatitis 39.56 15.50 146 43038 68151 46574727
Recurrent cancer 39.55 15.50 23 43161 1736 46641142
Urinary tract infection 39.55 15.50 91 43093 220175 46422703
Gastrooesophageal reflux disease 39.53 15.50 10 43174 74334 46568544
Fungal oesophagitis 39.19 15.50 16 43168 552 46642326
Plasma cell leukaemia 39.05 15.50 20 43164 1173 46641705
Contusion 39.04 15.50 16 43168 87471 46555407
Influenza like illness 38.93 15.50 4 43180 57566 46585312
Listeria sepsis 38.78 15.50 16 43168 567 46642311
Hyperhidrosis 38.78 15.50 17 43167 89291 46553587
Respiratory failure 38.68 15.50 182 43002 94634 46548244
Gastrointestinal fungal infection 38.63 15.50 13 43171 257 46642621
Nail pigmentation 38.49 15.50 12 43172 184 46642694
Chloroma 38.43 15.50 12 43172 185 46642693
Medulloblastoma recurrent 38.31 15.50 10 43174 77 46642801
Bacterial infection 38.20 15.50 60 43124 16156 46626722
Swelling 37.38 15.50 36 43148 124475 46518403
Enterococcal sepsis 36.86 15.50 20 43164 1320 46641558
Nasal abscess 36.82 15.50 11 43173 145 46642733
Back pain 36.72 15.50 88 43096 209951 46432927
Epstein Barr virus positive mucocutaneous ulcer 36.01 15.50 12 43172 230 46642648
Blood glucose increased 35.84 15.50 11 43173 72002 46570876
Oedema peripheral 35.59 15.50 58 43126 159648 46483230
Klebsiella infection 35.50 15.50 37 43147 6625 46636253
Unmasking of previously unidentified disease 35.30 15.50 16 43168 715 46642163
Angiocentric lymphoma 35.08 15.50 14 43170 455 46642423
Abdominal compartment syndrome 34.99 15.50 15 43169 586 46642292
Myocardial infarction 34.48 15.50 24 43160 97504 46545374
Clostridium bacteraemia 34.29 15.50 11 43173 186 46642692
Palpitations 34.27 15.50 23 43161 95236 46547642
Hair follicle tumour benign 34.22 15.50 13 43171 369 46642509
Staphylococcal infection 34.19 15.50 91 43093 35680 46607198
Pneumatosis intestinalis 34.07 15.50 22 43162 2003 46640875
Therapeutic product effect decreased 33.90 15.50 17 43167 82584 46560294
Klebsiella bacteraemia 33.60 15.50 18 43166 1158 46641720
Oesophageal candidiasis 33.46 15.50 32 43152 5168 46637710
Alopecia 33.45 15.50 62 43122 162352 46480526
Staphylococcal sepsis 33.44 15.50 38 43146 7494 46635384
Bone marrow transplant 33.42 15.50 15 43169 655 46642223
Pulmonary alveolar haemorrhage 33.42 15.50 29 43155 4133 46638745
Vision blurred 33.32 15.50 16 43168 79692 46563186
Weight decreased 33.28 15.50 93 43091 210756 46432122
Cardiomyopathy acute 33.19 15.50 11 43173 207 46642671
Hepatosplenomegaly 32.91 15.50 23 43161 2387 46640491
Sinus polyp 32.80 15.50 12 43172 306 46642572
Leukoerythroblastosis 32.52 15.50 11 43173 221 46642657
Subdural hygroma 32.52 15.50 11 43173 221 46642657
Escherichia bacteraemia 32.33 15.50 24 43160 2737 46640141
Hypogammaglobulinaemia 32.25 15.50 32 43152 5406 46637472
Hepatitis B 32.24 15.50 27 43157 3666 46639212
Inappropriate schedule of product administration 32.23 15.50 10 43174 65003 46577875
White blood cell count abnormal 31.93 15.50 31 43153 5101 46637777
Mucocutaneous ulceration 31.92 15.50 10 43174 156 46642722
Loss of personal independence in daily activities 31.76 15.50 7 43177 57176 46585702
Stress 31.43 15.50 5 43179 51546 46591332
Tumour necrosis 31.33 15.50 15 43169 760 46642118
Gastroenteritis norovirus 31.28 15.50 19 43165 1554 46641324
Incorrect dose administered 31.22 15.50 3 43181 45547 46597331
Staphylococcal bacteraemia 31.22 15.50 30 43154 4874 46638004
Musculoskeletal pain 31.00 15.50 13 43171 70115 46572763
Therapy non-responder 30.91 15.50 96 43088 41056 46601822
Respiratory distress 30.31 15.50 81 43103 31835 46611043
Fungal infection 30.16 15.50 77 43107 29443 46613435
Metastases to diaphragm 30.09 15.50 7 43177 31 46642847
Metastases to lung 30.09 15.50 43 43141 10653 46632225
Venous thrombosis 30.07 15.50 29 43155 4733 46638145
Loss of consciousness 29.45 15.50 34 43150 108204 46534674
Pseudomonal sepsis 29.45 15.50 20 43164 1982 46640896
Device related infection 29.32 15.50 62 43122 20979 46621899
Parainfluenzae virus infection 29.08 15.50 19 43165 1765 46641113
Sinusitis 29.03 15.50 47 43137 129721 46513157
Streptococcal bacteraemia 29.01 15.50 17 43167 1302 46641576
Bacterial sepsis 28.93 15.50 25 43159 3542 46639336
Pneumothorax 28.90 15.50 50 43134 14579 46628299
Respiratory symptom 28.84 15.50 20 43164 2050 46640828
Tremor 28.67 15.50 39 43145 115600 46527278
Epiphyses premature fusion 28.61 15.50 7 43177 40 46642838
Somnolence 28.61 15.50 64 43120 156457 46486421
Toxic encephalopathy 28.57 15.50 29 43155 5033 46637845
Pulmonary toxicity 28.54 15.50 28 43156 4665 46638213
Metastases to central nervous system 28.51 15.50 43 43141 11178 46631700
Renal failure 28.30 15.50 191 42993 113403 46529475
Listeriosis 28.20 15.50 16 43168 1153 46641725
Chronic graft versus host disease 28.19 15.50 22 43162 2703 46640175
Dry mouth 28.04 15.50 8 43176 54918 46587960
Drug clearance increased 28.01 15.50 8 43176 89 46642789
Respiratory syncytial virus infection 27.84 15.50 28 43156 4807 46638071
Sinoatrial block 27.61 15.50 14 43170 804 46642074
Hypoglycaemia 27.59 15.50 8 43176 54341 46588537
International normalised ratio increased 27.58 15.50 5 43179 46878 46596000
Ejection fraction decreased 27.52 15.50 55 43129 17882 46624996
Sleep disorder 27.51 15.50 5 43179 46790 46596088
Ocular vascular disorder 27.32 15.50 11 43173 366 46642512
Thymus enlargement 27.31 15.50 8 43176 98 46642780
Mucormycosis 27.01 15.50 20 43164 2272 46640606
Cytomegalovirus chorioretinitis 26.92 15.50 17 43167 1490 46641388
Aplastic anaemia 26.65 15.50 33 43151 7120 46635758
Chronic obstructive pulmonary disease 26.60 15.50 10 43174 57623 46585255
Delayed puberty 26.53 15.50 8 43176 109 46642769
Rhinovirus infection 26.53 15.50 24 43160 3612 46639266
Small cell lung cancer 26.49 15.50 17 43167 1532 46641346
Injection site reaction 26.29 15.50 6 43178 47843 46595035
Injection site pruritus 26.26 15.50 3 43181 39740 46603138
Tonsillar haemorrhage 26.10 15.50 9 43175 192 46642686
Paraneoplastic neurological syndrome 26.00 15.50 5 43179 6 46642872
Acute myelomonocytic leukaemia 25.59 15.50 9 43175 204 46642674
Injury 25.25 15.50 5 43179 44022 46598856
Histiocytic sarcoma 25.10 15.50 7 43177 71 46642807
Enteritis 24.91 15.50 31 43153 6724 46636154
Acute monocytic leukaemia 24.84 15.50 7 43177 74 46642804
Gastrointestinal toxicity 24.79 15.50 25 43159 4306 46638572
Myeloproliferative neoplasm 24.51 15.50 11 43173 480 46642398
Condition aggravated 24.50 15.50 130 43054 244922 46397956
Hypophosphataemia 24.32 15.50 32 43152 7335 46635543
Cerebrovascular accident 24.12 15.50 35 43149 101004 46541874
Metastases to bone marrow 24.12 15.50 9 43175 243 46642635
Necrotising gastritis 24.00 15.50 6 43178 38 46642840
Peripheral sensory neuropathy 23.86 15.50 30 43154 6573 46636305
Toxic neuropathy 23.68 15.50 10 43174 376 46642502
Neutrophil count abnormal 23.67 15.50 19 43165 2431 46640447
Spinal cord paralysis 23.61 15.50 6 43178 41 46642837
Cytogenetic abnormality 23.55 15.50 11 43173 527 46642351
Cytokine storm 23.54 15.50 9 43175 260 46642618
Glossodynia 23.52 15.50 6 43178 44367 46598511
Adverse drug reaction 23.51 15.50 6 43178 44356 46598522
Vena cava thrombosis 23.43 15.50 18 43166 2161 46640717
Pericardial effusion 23.42 15.50 64 43120 25479 46617399
Stenotrophomonas infection 23.39 15.50 16 43168 1604 46641274
Lower respiratory tract infection 23.11 15.50 11 43173 55078 46587800
Unevaluable event 23.07 15.50 7 43177 46168 46596710
Hypoaesthesia 23.05 15.50 47 43137 118822 46524056
Abortion spontaneous 22.95 15.50 6 43178 43640 46599238
Respiratory tract infection fungal 22.94 15.50 10 43174 407 46642471
Vulvovaginal inflammation 22.91 15.50 11 43173 561 46642317
Nasal congestion 22.79 15.50 8 43176 48105 46594773
Adrenocortical carcinoma 22.78 15.50 6 43178 48 46642830
Listeria encephalitis 22.64 15.50 8 43176 184 46642694
B-cell lymphoma recurrent 22.60 15.50 10 43174 422 46642456
Diabetes mellitus 22.58 15.50 9 43175 50056 46592822
Vertigo 22.45 15.50 10 43174 52038 46590840
Vulvovaginitis 22.42 15.50 9 43175 297 46642581
Metastases to lymph nodes 22.19 15.50 29 43155 6602 46636276
Viral haemorrhagic cystitis 22.19 15.50 11 43173 602 46642276
Acquired gene mutation 22.14 15.50 11 43173 605 46642273
Iris atrophy 22.06 15.50 6 43178 55 46642823
Radiation pneumonitis 22.00 15.50 14 43170 1243 46641635
Urinary tract infection bacterial 21.95 15.50 23 43161 4142 46638736
Genotoxicity 21.91 15.50 5 43179 20 46642858
Ependymoma 21.87 15.50 6 43178 57 46642821
Metastases to spleen 21.84 15.50 7 43177 118 46642760
Neck pain 21.78 15.50 12 43172 55294 46587584
Congenital retinoblastoma 21.71 15.50 5 43179 21 46642857
Paranasal sinus mucosal hypertrophy 21.71 15.50 5 43179 21 46642857
Burning sensation 21.71 15.50 7 43177 44404 46598474
Follicular thyroid cancer 21.68 15.50 6 43178 59 46642819
Splenomegaly 21.65 15.50 35 43149 9653 46633225
Plasma cell myeloma 21.62 15.50 90 43094 44388 46598490
Suicide attempt 21.58 15.50 12 43172 55024 46587854
Retroperitoneal abscess 21.57 15.50 7 43177 123 46642755
Pseudomonas infection 21.47 15.50 35 43149 9723 46633155
Metastasis 21.29 15.50 23 43161 4289 46638589
Retinal pigment epitheliopathy 21.23 15.50 8 43176 222 46642656
Primary mediastinal large B-cell lymphoma recurrent 21.07 15.50 6 43178 66 46642812
Gliosis 20.93 15.50 8 43176 231 46642647
Depressed mood 20.84 15.50 3 43181 33316 46609562
Neutropenic infection 20.73 15.50 13 43171 1125 46641753
Congestive cardiomyopathy 20.72 15.50 26 43158 5687 46637191
Serum ferritin increased 20.70 15.50 25 43159 5258 46637620
Trichosporon infection 20.61 15.50 8 43176 241 46642637
Ganglioneuroma 20.59 15.50 7 43177 143 46642735
Blood stem cell transplant failure 20.36 15.50 7 43177 148 46642730
Lung infiltration 20.29 15.50 42 43142 14001 46628877
Ewing's sarcoma 20.29 15.50 4 43180 6 46642872
Pneumocystis jirovecii pneumonia 20.17 15.50 44 43140 15204 46627674
Blood cholesterol increased 20.11 15.50 6 43178 40007 46602871
VIth nerve paresis 20.09 15.50 6 43178 79 46642799
Discomfort 20.07 15.50 9 43175 46661 46596217
Radiation oesophagitis 20.04 15.50 8 43176 260 46642618
Gastrointestinal mucosal disorder 20.00 15.50 11 43173 746 46642132
Enterobacter bacteraemia 19.98 15.50 8 43176 262 46642616
Vaccination failure 19.88 15.50 6 43178 82 46642796
Wrong technique in product usage process 19.76 15.50 13 43171 54409 46588469
Therapy partial responder 19.74 15.50 23 43161 4659 46638219
Central nervous system lymphoma 19.58 15.50 13 43171 1241 46641637
Metastases to breast 19.51 15.50 8 43176 279 46642599
Plasmacytoma 19.36 15.50 17 43167 2460 46640418
Enterocolitis 19.14 15.50 26 43158 6142 46636736
Clostridium colitis 19.05 15.50 15 43169 1867 46641011
Oral fungal infection 19.03 15.50 17 43167 2517 46640361
Balance disorder 18.95 15.50 19 43165 64502 46578376
Fluid retention 18.79 15.50 12 43172 51034 46591844
Hypomagnesaemia 18.74 15.50 54 43130 22156 46620722
B precursor type acute leukaemia 18.69 15.50 7 43177 191 46642687
Lymphoma 18.68 15.50 33 43151 9780 46633098
Pulmonary vascular disorder 18.58 15.50 8 43176 316 46642562
Gestational trophoblastic tumour 18.56 15.50 5 43179 44 46642834
Product quality issue 18.55 15.50 5 43179 35643 46607235
Mucosal erosion 18.30 15.50 13 43171 1385 46641493
Refractory cancer 18.17 15.50 5 43179 48 46642830
Transdifferentiation of neoplasm 18.17 15.50 4 43180 13 46642865
Vascular compression 18.05 15.50 6 43178 114 46642764
Amnesia 17.95 15.50 8 43176 41623 46601255
Neuroblastoma 17.90 15.50 5 43179 51 46642827
Peripheral motor neuropathy 17.66 15.50 13 43171 1463 46641415
Impaired healing 17.59 15.50 6 43178 36737 46606141
Engraft failure 17.56 15.50 8 43176 362 46642516
Hypoglossal nerve paresis 17.49 15.50 6 43178 126 46642752
Rectal fissure 17.49 15.50 9 43175 533 46642345
Cardiopulmonary failure 17.12 15.50 19 43165 3650 46639228
Respiratory arrest 17.12 15.50 5 43179 33811 46609067
Carcinoid crisis 17.10 15.50 7 43177 243 46642635
Surgery 17.08 15.50 3 43181 28782 46614096
Coronary artery disease 17.07 15.50 5 43179 33747 46609131
Constipation 17.03 15.50 93 43091 174004 46468874
B-cell lymphoma 17.02 15.50 18 43166 3276 46639602
Myelopathy 16.98 15.50 16 43168 2536 46640342
Salivary gland cancer 16.98 15.50 6 43178 138 46642740
Lung consolidation 16.71 15.50 19 43165 3748 46639130
Rhabdomyolysis 16.63 15.50 9 43175 41900 46600978
Cardiomyopathy 16.49 15.50 42 43142 16031 46626847
Drug clearance decreased 16.35 15.50 11 43173 1073 46641805
Schistocytosis 16.33 15.50 4 43180 23 46642855
Streptococcal sepsis 16.27 15.50 13 43171 1652 46641226
Chest pain 16.27 15.50 96 43088 176228 46466650
Meningoencephalitis bacterial 16.27 15.50 5 43179 73 46642805
Dry eye 16.26 15.50 4 43180 30318 46612560
Intra-abdominal haemorrhage 16.26 15.50 15 43169 2315 46640563
Product administered to patient of inappropriate age 16.24 15.50 16 43168 2680 46640198
Blood creatine phosphokinase increased 16.21 15.50 3 43181 27721 46615157
Gastroenteritis cryptosporidial 16.20 15.50 5 43179 74 46642804
Rhabdomyosarcoma recurrent 16.19 15.50 4 43180 24 46642854
Odynophagia 16.18 15.50 25 43159 6637 46636241
Flagellate dermatitis 16.15 15.50 6 43178 160 46642718
Hyperkalaemia 15.99 15.50 14 43170 50695 46592183
Low cardiac output syndrome 15.99 15.50 7 43177 288 46642590
Glioblastoma multiforme 15.94 15.50 10 43174 866 46642012
Hypoxia 15.92 15.50 92 43092 51746 46591132
Sinusitis fungal 15.92 15.50 10 43174 868 46642010
Osteosarcoma metastatic 15.91 15.50 4 43180 26 46642852
Platelet count abnormal 15.86 15.50 16 43168 2756 46640122
Pneumonia klebsiella 15.83 15.50 14 43170 2045 46640833
Osteonecrosis of jaw 15.82 15.50 6 43178 34396 46608482
Traumatic lung injury 15.79 15.50 12 43172 1418 46641460
Vomiting 15.71 15.50 538 42646 452256 46190622
Pneumonia respiratory syncytial viral 15.62 15.50 9 43175 668 46642210

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 2438.96 13.73 1883 58563 104810 29787222
Neutropenia 877.11 13.73 1182 59264 127358 29764674
Bone marrow failure 661.70 13.73 519 59927 29266 29862766
Mucosal inflammation 644.50 13.73 516 59930 29978 29862054
Acute myeloid leukaemia 601.70 13.73 402 60044 17604 29874428
Product use in unapproved indication 571.79 13.73 723 59723 72970 29819062
Pancytopenia 560.38 13.73 770 59676 84282 29807750
Myelodysplastic syndrome 489.22 13.73 360 60086 18418 29873614
Thrombocytopenia 435.83 13.73 895 59551 136149 29755883
Off label use 433.95 13.73 1291 59155 247999 29644033
Venoocclusive liver disease 333.54 13.73 192 60254 6421 29885611
Haematotoxicity 305.49 13.73 177 60269 5993 29886039
Second primary malignancy 284.95 13.73 171 60275 6185 29885847
Myelosuppression 272.55 13.73 175 60271 7147 29884885
Malignant neoplasm progression 259.13 13.73 497 59949 71790 29820242
Febrile bone marrow aplasia 240.03 13.73 168 60278 7929 29884103
Sepsis 229.19 13.73 732 59714 145663 29746369
Haemophagocytic lymphohistiocytosis 222.31 13.73 173 60273 9618 29882414
Tumour lysis syndrome 218.10 13.73 192 60254 12693 29879339
Septic shock 209.32 13.73 422 60024 63185 29828847
Leukopenia 187.63 13.73 375 60071 55784 29836248
Fall 178.48 13.73 72 60374 181800 29710232
Neoplasm progression 165.67 13.73 193 60253 17830 29874202
Neutropenic sepsis 165.65 13.73 156 60290 11253 29880779
Disease progression 158.66 13.73 435 60011 79439 29812593
Diffuse large B-cell lymphoma recurrent 150.84 13.73 77 60369 2015 29890017
Neutrophil count decreased 144.76 13.73 286 60160 42168 29849864
Pyrexia 140.79 13.73 1045 59401 293444 29598588
Product dose omission issue 137.65 13.73 13 60433 91618 29800414
Diffuse large B-cell lymphoma 137.01 13.73 119 60327 7722 29884310
Malignant transformation 136.00 13.73 52 60394 661 29891371
Fatigue 135.38 13.73 278 60168 320395 29571637
Bronchopulmonary aspergillosis 132.50 13.73 143 60303 12141 29879891
Cardiotoxicity 131.77 13.73 92 60354 4322 29887710
Diffuse large B-cell lymphoma refractory 131.66 13.73 52 60394 725 29891307
Posterior reversible encephalopathy syndrome 130.13 13.73 121 60325 8586 29883446
Venoocclusive disease 127.39 13.73 74 60372 2516 29889516
Aspergillus infection 126.45 13.73 128 60318 10086 29881946
Aplasia 124.87 13.73 86 60360 3951 29888081
Dizziness 124.50 13.73 126 60320 194783 29697249
Stem cell transplant 124.07 13.73 68 60378 2063 29889969
Stomatitis 122.11 13.73 247 60199 37032 29855000
Cytopenia 121.98 13.73 114 60332 8142 29883890
Neoplasm recurrence 109.87 13.73 60 60386 1807 29890225
Overdose 109.73 13.73 19 60427 84318 29807714
Acute graft versus host disease 108.56 13.73 92 60354 5772 29886260
Depression 108.02 13.73 25 60421 90412 29801620
Therapy partial responder 108.01 13.73 76 60370 3615 29888417
Insomnia 107.20 13.73 28 60418 93308 29798724
Malaise 98.73 13.73 115 60331 166847 29725185
Cystitis haemorrhagic 96.71 13.73 79 60367 4708 29887324
Encephalopathy 95.65 13.73 205 60241 32000 29860032
Acute lymphocytic leukaemia 89.30 13.73 63 60383 3009 29889023
Arthralgia 88.66 13.73 86 60360 135705 29756327
Drug interaction 88.31 13.73 168 60278 199400 29692632
Disease recurrence 85.18 13.73 123 60323 14038 29877994
Death 85.02 13.73 402 60044 356881 29535151
Neutropenic colitis 84.70 13.73 54 60392 2176 29889856
Neurotoxicity 84.46 13.73 118 60328 13064 29878968
Pain 83.90 13.73 137 60309 172504 29719528
Rash 83.62 13.73 163 60283 191726 29700306
Peripheral swelling 83.40 13.73 12 60434 61062 29830970
Tremor 82.08 13.73 25 60421 75338 29816694
Fungal infection 81.61 13.73 118 60328 13482 29878550
Joint swelling 81.45 13.73 3 60443 46943 29845089
Cytomegalovirus infection 81.27 13.73 160 60286 23514 29868518
Colitis 81.18 13.73 187 60259 30633 29861399
Anxiety 81.07 13.73 40 60406 89831 29802201
Bacteraemia 80.55 13.73 126 60320 15434 29876598
Anaemia 80.48 13.73 704 59742 207288 29684744
Blood pressure increased 79.91 13.73 23 60423 71905 29820127
Sweat gland tumour 77.37 13.73 30 60416 397 29891635
Cardiac failure congestive 76.99 13.73 37 60409 84370 29807662
Multiple organ dysfunction syndrome 75.24 13.73 290 60156 63197 29828835
Respiratory failure 73.17 13.73 398 60048 100244 29791788
Anaplastic lymphoma kinase gene mutation 70.61 13.73 20 60426 88 29891944
Coronary artery disease 69.69 13.73 9 60437 49703 29842329
Myocardial infarction 66.47 13.73 94 60352 125531 29766501
Progressive multifocal leukoencephalopathy 65.83 13.73 86 60360 8927 29883105
Chloroma 62.35 13.73 26 60420 420 29891612
Pulmonary toxicity 62.21 13.73 60 60386 4456 29887576
Lymphopenia 60.50 13.73 101 60345 13062 29878970
Systemic mycosis 60.48 13.73 35 60411 1181 29890851
Adenovirus infection 59.35 13.73 57 60389 4211 29887821
Blood glucose increased 59.18 13.73 25 60421 61505 29830527
Hepatitis B 59.10 13.73 67 60379 6005 29886027
Candida infection 59.10 13.73 109 60337 15253 29876779
Acute promyelocytic leukaemia 59.09 13.73 27 60419 549 29891483
Pruritus 59.07 13.73 92 60354 118112 29773920
Nasopharyngitis 58.08 13.73 23 60423 58826 29833206
Enterococcal bacteraemia 58.07 13.73 36 60410 1380 29890652
Weight decreased 57.55 13.73 138 60308 150783 29741249
Chronic graft versus host disease 57.26 13.73 55 60391 4064 29887968
White blood cell count decreased 57.01 13.73 326 60120 83621 29808411
Epstein-Barr virus infection 56.96 13.73 69 60377 6637 29885395
Weight increased 56.78 13.73 41 60405 74872 29817160
Epstein-Barr virus associated lymphoproliferative disorder 56.26 13.73 38 60408 1690 29890342
Drug resistance 56.17 13.73 125 60321 20008 29872024
Aggression 56.02 13.73 5 60441 36902 29855130
Hypoglycaemia 55.34 13.73 17 60429 50964 29841068
Headache 55.31 13.73 186 60260 182120 29709912
Osteosarcoma 54.97 13.73 19 60427 177 29891855
Acute graft versus host disease in skin 54.81 13.73 56 60390 4460 29887572
Chest pain 54.64 13.73 96 60350 117531 29774501
Musculoskeletal stiffness 54.08 13.73 5 60441 35876 29856156
Azoospermia 53.67 13.73 23 60423 399 29891633
Enterococcal infection 53.24 13.73 74 60372 8150 29883882
Somnolence 52.57 13.73 71 60375 96692 29795340
Bacterial sepsis 52.50 13.73 57 60389 4869 29887163
Oedema peripheral 52.27 13.73 83 60363 105749 29786283
Myalgia 51.82 13.73 47 60399 76620 29815412
Renal tubular disorder 51.75 13.73 57 60389 4949 29887083
Feeling abnormal 51.55 13.73 25 60421 56731 29835301
Inappropriate schedule of product administration 51.53 13.73 9 60437 39719 29852313
Vena cava thrombosis 51.42 13.73 30 60416 1028 29891004
Neuropathy peripheral 51.37 13.73 279 60167 70196 29821836
Pneumonitis 50.94 13.73 146 60300 27308 29864724
Ameloblastoma 50.75 13.73 15 60431 79 29891953
Nephropathy toxic 50.73 13.73 83 60363 10556 29881476
Blood stem cell transplant failure 50.24 13.73 22 60424 403 29891629
Psoriasis 50.22 13.73 12 60434 42494 29849538
Staphylococcal bacteraemia 50.08 13.73 65 60381 6703 29885329
Cytomegalovirus chorioretinitis 49.96 13.73 46 60400 3222 29888810
Pulmonary vascular disorder 49.87 13.73 21 60425 348 29891684
Cerebrovascular accident 49.80 13.73 57 60389 83420 29808612
Muscle spasms 49.77 13.73 35 60411 64803 29827229
Asthma 49.63 13.73 7 60439 36167 29855865
Ependymoma 48.81 13.73 14 60432 65 29891967
Small cell lung cancer 48.81 13.73 36 60410 1844 29890188
Neuroblastoma 48.01 13.73 18 60428 216 29891816
Rheumatoid arthritis 47.95 13.73 12 60434 41185 29850847
Hyperkalaemia 47.62 13.73 38 60408 65972 29826060
B-cell lymphoma recurrent 47.32 13.73 24 60422 619 29891413
Diaphragm muscle weakness 47.01 13.73 14 60432 76 29891956
Hepatitis B reactivation 46.93 13.73 42 60404 2835 29889197
Pneumocystis jirovecii pneumonia 46.31 13.73 105 60341 17015 29875017
Acute respiratory distress syndrome 45.67 13.73 127 60319 23345 29868687
Graft versus host disease 45.47 13.73 77 60369 10073 29881959
Rhabdomyolysis 45.37 13.73 37 60409 63543 29828489
Platelet count decreased 45.02 13.73 367 60079 105762 29786270
Klebsiella sepsis 44.85 13.73 33 60413 1684 29890348
Medulloblastoma recurrent 44.71 13.73 13 60433 64 29891968
Clostridium difficile colitis 44.66 13.73 87 60359 12681 29879351
Hospitalisation 44.26 13.73 17 60429 44302 29847730
Retinal haemorrhage 43.91 13.73 51 60395 4692 29887340
T-cell type acute leukaemia 43.84 13.73 16 60430 177 29891855
Fusarium infection 43.51 13.73 27 60419 1037 29890995
Pain in extremity 43.42 13.73 99 60347 110122 29781910
Pneumonia klebsiella 42.62 13.73 38 60408 2552 29889480
Chronic obstructive pulmonary disease 42.37 13.73 20 60426 46106 29845926
Urinary tract infection 42.11 13.73 52 60394 73607 29818425
Papillary thyroid cancer 41.67 13.73 22 60424 618 29891414
Refractory cancer 41.63 13.73 14 60432 119 29891913
Hypogammaglobulinaemia 41.32 13.73 52 60394 5200 29886832
Drug hypersensitivity 40.63 13.73 47 60399 68472 29823560
Blood creatine phosphokinase increased 40.30 13.73 19 60427 43829 29848203
Influenza like illness 40.15 13.73 3 60443 25602 29866430
Lymphadenopathy 39.88 13.73 124 60322 24252 29867780
Gait disturbance 39.47 13.73 56 60390 74721 29817311
Incorrect dose administered 39.34 13.73 8 60438 31678 29860354
Escherichia bacteraemia 38.93 13.73 38 60408 2864 29889168
Central nervous system fungal infection 38.68 13.73 16 60430 253 29891779
Recurrent cancer 38.62 13.73 26 60420 1150 29890882
Systemic candida 38.59 13.73 37 60409 2727 29889305
Agranulocytosis 38.13 13.73 114 60332 21828 29870204
Hallucination 36.97 13.73 27 60419 49032 29843000
Thrombotic microangiopathy 36.84 13.73 64 60382 8546 29883486
Metastasis 36.62 13.73 39 60407 3259 29888773
Engraftment syndrome 36.26 13.73 22 60424 811 29891221
Haematochezia 36.09 13.73 12 60434 34210 29857822
Pulmonary arteriopathy 36.01 13.73 11 60435 66 29891966
Testicular germ cell cancer metastatic 35.87 13.73 11 60435 67 29891965
Drug reaction with eosinophilia and systemic symptoms 35.77 13.73 7 60439 28481 29863551
Hyperhidrosis 35.65 13.73 50 60396 67040 29824992
Sleep disorder 35.36 13.73 4 60442 24475 29867557
Arthritis 35.22 13.73 4 60442 24397 29867635
Balance disorder 34.81 13.73 15 60431 36478 29855554
Cytogenetic abnormality 34.64 13.73 21 60425 773 29891259
Ganglioneuroblastoma 34.45 13.73 9 60437 27 29892005
Vision blurred 34.21 13.73 21 60425 41795 29850237
Peripheral T-cell lymphoma unspecified 33.98 13.73 18 60428 509 29891523
Delayed puberty 33.94 13.73 13 60433 166 29891866
Unevaluable event 33.77 13.73 11 60435 31774 29860258
Nephrolithiasis 33.57 13.73 5 60441 24805 29867227
Mucormycosis 33.50 13.73 47 60399 5221 29886811
Cellulitis gangrenous 33.39 13.73 13 60433 174 29891858
Fanconi syndrome 33.16 13.73 28 60418 1747 29890285
Loss of consciousness 33.14 13.73 69 60377 79306 29812726
Osteonecrosis 33.08 13.73 89 60357 16046 29875986
Metastases to liver 33.04 13.73 74 60372 11891 29880141
Angioedema 33.01 13.73 14 60432 34370 29857662
Abdominal discomfort 32.85 13.73 30 60416 48761 29843271
Human herpesvirus 6 infection 32.76 13.73 29 60417 1929 29890103
Medulloblastoma 32.46 13.73 10 60436 62 29891970
Juvenile melanoma benign 32.06 13.73 10 60436 65 29891967
Escherichia infection 31.94 13.73 51 60395 6354 29885678
Bradycardia 31.76 13.73 52 60394 65474 29826558
Dyspnoea 31.32 13.73 479 59967 332816 29559216
Stenotrophomonas infection 31.13 13.73 26 60420 1598 29890434
Urticaria 30.73 13.73 39 60407 54567 29837465
Primitive neuroectodermal tumour 30.71 13.73 10 60436 76 29891956
Toxic encephalopathy 30.63 13.73 42 60404 4567 29887465
Carotid artery thrombosis 30.60 13.73 15 60431 359 29891673
Pancreatic neuroendocrine tumour metastatic 30.47 13.73 12 60434 166 29891866
Therapy non-responder 30.44 13.73 129 60317 29324 29862708
Extravasation 30.44 13.73 27 60419 1801 29890231
Acute lymphocytic leukaemia recurrent 30.43 13.73 32 60414 2635 29889397
Injury 30.29 13.73 4 60442 21727 29870305
Minimal residual disease 30.26 13.73 13 60433 227 29891805
Leukaemia recurrent 29.94 13.73 25 60421 1536 29890496
Salivary gland cancer 29.85 13.73 13 60433 235 29891797
Aortic thrombosis 29.58 13.73 18 60428 667 29891365
Back pain 29.50 13.73 107 60339 102489 29789543
Hepatotoxicity 29.40 13.73 92 60354 18053 29873979
Body height below normal 29.35 13.73 13 60433 245 29891787
Enteritis 29.22 13.73 50 60396 6595 29885437
Cardio-respiratory arrest 29.17 13.73 44 60402 57262 29834770
Rhabdomyosarcoma recurrent 29.14 13.73 10 60436 91 29891941
Teratoma 29.13 13.73 7 60439 13 29892019
Renal salt-wasting syndrome 29.04 13.73 11 60435 136 29891896
Eosinophilia 28.78 13.73 5 60441 22155 29869877
Nervous system disorder 28.74 13.73 74 60372 12995 29879037
Memory impairment 28.60 13.73 20 60426 37154 29854878
Embolism 28.56 13.73 51 60395 6958 29885074
Capillary leak syndrome 28.45 13.73 25 60421 1647 29890385
Aspiration bone marrow abnormal 28.21 13.73 10 60436 101 29891931
Metastases to retroperitoneum 28.11 13.73 12 60434 206 29891826
Electrocardiogram QT prolonged 27.95 13.73 19 60427 35816 29856216
Diabetes mellitus 27.87 13.73 26 60420 41839 29850193
Encephalitis enteroviral 27.87 13.73 11 60435 153 29891879
Metastases to lung 27.86 13.73 54 60392 7841 29884191
Hepatic infection fungal 27.81 13.73 11 60435 154 29891878
High-grade B-cell lymphoma 27.74 13.73 11 60435 155 29891877
Loss of personal independence in daily activities 27.66 13.73 5 60441 21530 29870502
Cardiac disorder 27.49 13.73 24 60422 39869 29852163
Intestinal atresia 27.24 13.73 9 60437 72 29891960
Pulmonary haemorrhage 26.96 13.73 59 60387 9333 29882699
Refractory anaemia with an excess of blasts 26.89 13.73 14 60432 382 29891650
Short stature 26.78 13.73 8 60438 44 29891988
Hepatic candidiasis 26.48 13.73 8 60438 46 29891986
Neutrophil count abnormal 26.33 13.73 22 60424 1353 29890679
Bacterial infection 26.30 13.73 70 60376 12540 29879492
Hypophosphataemia 26.22 13.73 54 60392 8191 29883841
Candida sepsis 26.20 13.73 20 60426 1079 29890953
Mantle cell lymphoma recurrent 26.02 13.73 14 60432 409 29891623
Cardiac arrest 25.92 13.73 98 60348 92752 29799280
Cytokine release syndrome 25.84 13.73 60 60386 9873 29882159
Abdominal pain upper 25.58 13.73 55 60391 62496 29829536
Device related infection 25.50 13.73 84 60362 16931 29875101
Bicytopenia 25.39 13.73 24 60422 1738 29890294
Trichosporon infection 25.27 13.73 16 60430 637 29891395
Pulmonary veno-occlusive disease 25.18 13.73 14 60432 437 29891595
Intussusception 25.14 13.73 15 60431 536 29891496
Graft versus host disease in gastrointestinal tract 25.12 13.73 31 60415 3038 29888994
Metastases to muscle 25.10 13.73 11 60435 202 29891830
Lactic acidosis 25.08 13.73 16 60430 31197 29860835
Metastases to central nervous system 24.71 13.73 49 60397 7235 29884797
Pneumocystis jirovecii infection 24.68 13.73 21 60425 1324 29890708
Hypoalbuminaemia 24.59 13.73 63 60383 11029 29881003
Pneumonia aspiration 24.52 13.73 24 60422 37756 29854276
Disseminated intravascular coagulation 24.39 13.73 99 60347 22072 29869960
Geotrichum infection 24.36 13.73 14 60432 466 29891566
Swelling 24.36 13.73 22 60424 35953 29856079
Hypertensive hydrocephalus 24.21 13.73 8 60438 64 29891968
Klebsiella infection 24.17 13.73 47 60399 6840 29885192
Gastrooesophageal reflux disease 23.97 13.73 18 60428 32237 29859795
Blood cholesterol increased 23.95 13.73 3 60443 16967 29875065
Contusion 23.84 13.73 17 60429 31263 29860769
Abnormal behaviour 23.70 13.73 11 60435 25612 29866420
Liver function test abnormal 23.35 13.73 17 60429 30933 29861099
Wheezing 23.34 13.73 17 60429 30921 29861111
Serotonin syndrome 23.31 13.73 4 60442 17887 29874145
Graft versus host disease in skin 23.29 13.73 31 60415 3276 29888756
Toxicity to various agents 23.22 13.73 237 60209 176946 29715086
Anaplastic large-cell lymphoma 23.10 13.73 10 60436 178 29891854
Carbamoyl phosphate synthetase deficiency 22.97 13.73 6 60440 18 29892014
Leukoencephalopathy 22.95 13.73 34 60412 3968 29888064
Papilloedema 22.93 13.73 26 60420 2330 29889702
Streptococcal bacteraemia 22.65 13.73 22 60424 1648 29890384
Dyskinesia 22.42 13.73 8 60438 21826 29870206
Plasma cell leukaemia 22.42 13.73 17 60429 908 29891124
Abdominal distension 22.40 13.73 36 60410 45673 29846359
Delayed engraftment 22.38 13.73 8 60438 83 29891949
Syncope 22.18 13.73 92 60354 84811 29807221
BK virus infection 22.11 13.73 35 60411 4329 29887703
Bronchitis 21.95 13.73 28 60418 39097 29852935
Gastrointestinal mucosal disorder 21.92 13.73 12 60434 363 29891669
Stomatitis necrotising 21.80 13.73 8 60438 90 29891942
Gallbladder empyema 21.64 13.73 7 60439 52 29891980
Erectile dysfunction 21.60 13.73 5 60441 18097 29873935
Lung infiltration 21.58 13.73 65 60381 12494 29879538
Myelopathy 21.58 13.73 23 60423 1924 29890108
Herpes simplex 21.52 13.73 35 60411 4429 29887603
Disturbance in attention 21.25 13.73 9 60437 22120 29869912
Heart rate decreased 21.04 13.73 8 60438 20986 29871046
Metastases to bone marrow 21.02 13.73 13 60433 496 29891536
Gastrointestinal toxicity 20.99 13.73 23 60423 1985 29890047
Visceral oedema 20.91 13.73 5 60441 9 29892023
Respiratory arrest 20.89 13.73 17 60429 29241 29862791
Traumatic lung injury 20.78 13.73 18 60428 1163 29890869
Seminoma 20.76 13.73 10 60436 230 29891802
Adrenocortical carcinoma 20.72 13.73 6 60440 29 29892003
Osteonecrosis of jaw 20.57 13.73 6 60440 18612 29873420
Basal cell naevus syndrome 20.56 13.73 6 60440 30 29892002
Paternal exposure timing unspecified 20.56 13.73 6 60440 30 29892002
Transformation to acute myeloid leukaemia 20.54 13.73 14 60432 632 29891400
Arrhythmia 20.47 13.73 22 60424 33147 29858885
Peripheral sensory neuropathy 20.38 13.73 40 60406 5861 29886171
Subdural haemorrhage 20.34 13.73 27 60419 2845 29889187
Treatment noncompliance 20.21 13.73 13 60433 25240 29866792
Streptococcal infection 20.15 13.73 35 60411 4673 29887359
Transient ischaemic attack 20.14 13.73 13 60433 25187 29866845
Neuroblastoma recurrent 20.08 13.73 7 60439 67 29891965
Mobility decreased 19.98 13.73 14 60432 25985 29866047
Burkitt's lymphoma 19.92 13.73 9 60437 178 29891854
Road traffic accident 19.81 13.73 5 60441 17066 29874966
Therapy responder 19.79 13.73 9 60437 181 29891851
Flatulence 19.75 13.73 6 60440 18123 29873909
Head injury 19.72 13.73 5 60441 17015 29875017
Influenza 19.60 13.73 36 60410 43362 29848670
Staphylococcal infection 19.59 13.73 116 60330 30108 29861924
Emotional distress 19.53 13.73 4 60442 15761 29876271
Intestinal perforation 19.52 13.73 49 60397 8470 29883562
Renal infarct 19.45 13.73 17 60429 1112 29890920
Flagellate dermatitis 19.39 13.73 5 60441 14 29892018
Atypical teratoid/rhabdoid tumour of CNS 19.39 13.73 5 60441 14 29892018
Pneumonia cytomegaloviral 19.37 13.73 26 60420 2770 29889262
Expanded disability status scale score increased 19.35 13.73 9 60437 191 29891841
Myeloid leukaemia 19.31 13.73 11 60435 360 29891672
Splenic infarction 19.24 13.73 21 60425 1804 29890228
Enterocolitis 19.19 13.73 42 60404 6645 29885387
Graft versus host disease in liver 19.12 13.73 16 60430 986 29891046
Staphylococcal sepsis 19.10 13.73 52 60394 9439 29882593
Blood culture positive 19.04 13.73 35 60411 4884 29887148
Autoimmune neutropenia 18.94 13.73 10 60436 281 29891751
Cerebral venous thrombosis 18.93 13.73 13 60433 594 29891438
Wrong technique in product usage process 18.86 13.73 21 60425 31134 29860898
Clostridium test positive 18.85 13.73 22 60424 2034 29889998
Escherichia sepsis 18.82 13.73 31 60415 3963 29888069
Premature ageing 18.67 13.73 7 60439 84 29891948
Peripheral T-cell lymphoma unspecified stage III 18.61 13.73 6 60440 44 29891988
Diverticulitis 18.60 13.73 6 60440 17439 29874593
Metastases to meninges 18.56 13.73 17 60429 1182 29890850
Acute myelomonocytic leukaemia 18.45 13.73 8 60438 143 29891889
Faeces discoloured 18.43 13.73 3 60443 13943 29878089
Dehydration 18.41 13.73 160 60286 123379 29768653
Adverse drug reaction 18.41 13.73 12 60434 23133 29868899
Blood pressure systolic increased 18.37 13.73 4 60442 15106 29876926
Cerebral venous sinus thrombosis 18.37 13.73 10 60436 299 29891733
Hyperlipidaemia 18.36 13.73 3 60443 13904 29878128
Blindness cortical 18.31 13.73 10 60436 301 29891731
Chromaturia 18.29 13.73 3 60443 13862 29878170
Therapeutic product effect decreased 18.27 13.73 19 60427 29057 29862975
Epstein-Barr viraemia 18.26 13.73 15 60431 901 29891131
Accidental overdose 18.26 13.73 7 60439 18268 29873764
Reticulocytosis 18.25 13.73 10 60436 303 29891729
Refractory cytopenia with multilineage dysplasia 18.10 13.73 8 60438 150 29891882
Arterial thrombosis 18.09 13.73 18 60428 1388 29890644
Ischaemic cerebral infarction 18.07 13.73 15 60431 914 29891118
Burns first degree 18.07 13.73 4 60442 4 29892028
Dry mouth 17.97 13.73 12 60434 22838 29869194
Vomiting 17.92 13.73 575 59871 219243 29672789
Chemotherapy 17.88 13.73 12 60434 528 29891504
Pneumomediastinum 17.83 13.73 20 60426 1771 29890261
Hypokalaemia 17.83 13.73 167 60279 50025 29842007
Pseudomonas infection 17.77 13.73 54 60392 10428 29881604
Lethargy 17.65 13.73 33 60413 39486 29852546
Pancreatitis 17.63 13.73 29 60417 36461 29855571
Metastases to lymph nodes 17.59 13.73 30 60416 3947 29888085
Gene mutation 17.54 13.73 14 60432 807 29891225
Amnesia 17.53 13.73 14 60432 24307 29867725
Pulmonary fibrosis 17.51 13.73 71 60375 15819 29876213
Human herpesvirus 8 infection 17.45 13.73 13 60433 676 29891356
Cerebral toxoplasmosis 17.40 13.73 18 60428 1454 29890578
Metastases to spleen 17.40 13.73 10 60436 333 29891699
Hyperbilirubinaemia 17.34 13.73 74 60372 16868 29875164
Psychotic disorder 17.32 13.73 11 60435 21504 29870528
Hirsutism 17.27 13.73 8 60438 168 29891864
Adenomatous polyposis coli 17.23 13.73 8 60438 169 29891863
Asthenia 17.17 13.73 329 60117 220961 29671071
Autoimmune haemolytic anaemia 17.14 13.73 30 60416 4029 29888003
Platelet transfusion 17.13 13.73 15 60431 983 29891049
Myelitis transverse 17.11 13.73 15 60431 985 29891047
International normalised ratio increased 17.11 13.73 45 60401 47694 29844338
Neuroendocrine tumour of the lung metastatic 17.08 13.73 7 60439 108 29891924
Swollen tongue 17.08 13.73 3 60443 13189 29878843
Guillain-Barre syndrome 17.01 13.73 34 60412 5049 29886983
Cardiomyopathy 16.96 13.73 68 60378 15075 29876957
Neoplasm 16.94 13.73 30 60416 4066 29887966
Laboratory test abnormal 16.90 13.73 7 60439 17435 29874597
Infected neoplasm 16.89 13.73 6 60440 61 29891971
Poikiloderma 16.89 13.73 8 60438 177 29891855
Angiodysplasia 16.82 13.73 11 60435 463 29891569
Inflammatory pseudotumour 16.66 13.73 5 60441 28 29892004
Speech disorder 16.58 13.73 15 60431 24497 29867535
Acanthamoeba infection 16.55 13.73 11 60435 476 29891556
Radiation oesophagitis 16.52 13.73 10 60436 367 29891665
Congenital hepatobiliary anomaly 16.51 13.73 5 60441 29 29892003
Herpes simplex reactivation 16.51 13.73 5 60441 29 29892003
Migraine 16.51 13.73 3 60443 12871 29879161
Intentional product use issue 16.50 13.73 128 60318 36312 29855720
Musculoskeletal pain 16.48 13.73 23 60423 30917 29861115
Renal disorder 16.47 13.73 14 60432 23570 29868462
Chronic myeloid leukaemia 16.40 13.73 23 60423 2554 29889478
Ototoxicity 16.38 13.73 17 60429 1379 29890653
Retinoblastoma 16.37 13.73 5 60441 30 29892002
Diabetes mellitus inadequate control 16.31 13.73 3 60443 12759 29879273
Pulmonary alveolar haemorrhage 16.30 13.73 39 60407 6542 29885490
Ewing's sarcoma 16.23 13.73 5 60441 31 29892001
Mucosal toxicity 16.22 13.73 8 60438 194 29891838
Chest discomfort 16.20 13.73 43 60403 45437 29846595
Hepatic cirrhosis 16.20 13.73 6 60440 15993 29876039
Pneumonia fungal 16.16 13.73 35 60411 5498 29886534
Cerebral artery occlusion 16.14 13.73 13 60433 759 29891273
Choriocarcinoma 15.96 13.73 5 60441 33 29891999
Product quality issue 15.96 13.73 9 60437 18765 29873267
Neuroendocrine carcinoma 15.95 13.73 10 60436 391 29891641
Paraparesis 15.81 13.73 19 60427 1812 29890220
Prostate cancer 15.80 13.73 15 60431 23942 29868090
Chronic myelomonocytic leukaemia 15.78 13.73 12 60434 644 29891388
Rectal haemorrhage 15.76 13.73 29 60417 34910 29857122
Iris atrophy 15.64 13.73 6 60440 77 29891955
Nasal congestion 15.64 13.73 9 60437 18557 29873475
Erythema ab igne 15.62 13.73 3 60443 0 29892032
Li-Fraumeni syndrome 15.62 13.73 3 60443 0 29892032
Decreased appetite 15.57 13.73 211 60235 149699 29742333
Delirium 15.57 13.73 37 60409 40594 29851438
Procalcitonin decreased 15.57 13.73 4 60442 11 29892021
Fibrinous bronchitis 15.57 13.73 4 60442 11 29892021
Histiocytic sarcoma 15.57 13.73 4 60442 11 29892021
Thyroid cancer 15.50 13.73 16 60430 1289 29890743
Clostridium colitis 15.50 13.73 16 60430 1289 29890743
Clostridium difficile infection 15.44 13.73 68 60378 15715 29876317
Angiocentric lymphoma 15.41 13.73 9 60437 309 29891723
Burning sensation 15.35 13.73 7 60439 16467 29875565
Cytomegalovirus viraemia 15.33 13.73 35 60411 5694 29886338
Mediastinum neoplasm 15.31 13.73 4 60442 12 29892020
Adenocarcinoma gastric 15.30 13.73 15 60431 1136 29890896
Myoclonus 15.25 13.73 4 60442 13308 29878724
Salivary gland cancer stage IV 15.24 13.73 5 60441 39 29891993
Cytomegalovirus infection reactivation 15.14 13.73 18 60428 1697 29890335
Vertigo 15.13 13.73 14 60432 22621 29869411
Cerebral artery stenosis 15.10 13.73 9 60437 321 29891711
Superior vena cava syndrome 15.08 13.73 10 60436 431 29891601
Testicular germ cell cancer 15.07 13.73 4 60442 13 29892019
Rash pruritic 15.04 13.73 14 60432 22558 29869474
Platelet count abnormal 14.94 13.73 21 60425 2336 29889696
Primary hypogonadism 14.91 13.73 6 60440 88 29891944
Acute myeloid leukaemia recurrent 14.89 13.73 17 60429 1535 29890497
Dry skin 14.88 13.73 14 60432 22440 29869592
Oesophagitis 14.86 13.73 53 60393 11118 29880914
Blastic plasmacytoid dendritic cell neoplasia 14.85 13.73 6 60440 89 29891943
Electrolyte imbalance 14.82 13.73 54 60392 11446 29880586
Blood glucose decreased 14.81 13.73 4 60442 13049 29878983
Neutropenic infection 14.78 13.73 14 60432 1016 29891016
Arachnoiditis 14.78 13.73 9 60437 334 29891698
Fungal sepsis 14.78 13.73 12 60434 709 29891323
5q minus syndrome 14.73 13.73 7 60439 156 29891876
Pneumonia adenoviral 14.73 13.73 7 60439 156 29891876
Non-Hodgkin's lymphoma unspecified histology aggressive 14.72 13.73 5 60441 44 29891988
Skin exfoliation 14.72 13.73 15 60431 23157 29868875
Hepatitis D 14.62 13.73 5 60441 45 29891987
Bone sarcoma 14.61 13.73 6 60440 93 29891939
Deafness 14.61 13.73 50 60396 10275 29881757
Recall phenomenon 14.50 13.73 11 60435 588 29891444
Lymphoma transformation 14.49 13.73 7 60439 162 29891870
Agitation 14.49 13.73 58 60388 54015 29838017
Mucoepidermoid carcinoma 14.43 13.73 4 60442 16 29892016
Adenoviral hepatitis 14.38 13.73 7 60439 165 29891867
Hepatic necrosis 14.34 13.73 27 60419 3836 29888196
Colony stimulating factor therapy 14.34 13.73 7 60439 166 29891866
Fungal endocarditis 14.26 13.73 7 60439 168 29891864
Hepatic steatosis 14.23 13.73 6 60440 14787 29877245
Meningioma 14.17 13.73 16 60430 1427 29890605
Surgery 14.16 13.73 3 60443 11548 29880484
Pleural effusion 14.16 13.73 219 60227 73847 29818185
Lower respiratory tract infection 14.09 13.73 20 60426 26694 29865338
Varicella zoster virus infection 14.09 13.73 15 60431 1253 29890779
Ewing's sarcoma recurrent 14.05 13.73 4 60442 18 29892014
Decorticate posture 14.05 13.73 4 60442 18 29892014
Hypertension 14.01 13.73 167 60279 121187 29770845
Confusional state 13.92 13.73 190 60256 134644 29757388
Sudden death 13.79 13.73 7 60439 15485 29876547

Pharmacologic Action:

SourceCodeDescription
ATC L01CB01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Podophyllotoxin derivatives
FDA MoA N0000000176 Topoisomerase Inhibitors
FDA EPC N0000175609 Topoisomerase Inhibitor
CHEBI has role CHEBI:35610 cytostatic
CHEBI has role CHEBI:59517 dna synthesis inhibitors
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000972 Antineoplastic Agents, Phytogenic
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Small cell carcinoma of lung indication 254632001 DOID:5409
Malignant tumor of testis indication 363449006 DOID:2998
Allogeneic bone marrow transplantation off-label use 58390007
Ewing's sarcoma off-label use 76909002 DOID:3369
Acute myeloid leukemia, disease off-label use 91861009
Kaposi's sarcoma off-label use 109385007
Diffuse non-Hodgkin's lymphoma, large cell off-label use 109969005
Multiple myeloma off-label use 109989006 DOID:9538
Hodgkin's disease off-label use 118599009
Burkitt's lymphoma off-label use 118617000
Non-small cell lung cancer off-label use 254637007 DOID:3908
Osteosarcoma of bone off-label use 307576001 DOID:3376
Malignant tumor of ovary off-label use 363443007 DOID:2394
Neuroblastoma off-label use 432328008 DOID:769
Neuroendocrine Prostate Carcinoma off-label use
Progressive Diffuse Large B-Cell Lymphoma off-label use
Testicular Germ Cell Tumor off-label use
Ovarian Germ Cell Tumor Carcinoma off-label use
Acute hemorrhage contraindication 8573003
Fibrosis of lung contraindication 51615001 DOID:3770
Metabolic acidosis contraindication 59455009
Acute infectious disease contraindication 63171007
Interstitial pneumonia contraindication 64667001
Leukopenia contraindication 84828003 DOID:615
Hypoalbuminemia contraindication 119247004
Impaired renal function disorder contraindication 197663003
Drug-induced hepatitis contraindication 235876009
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Breastfeeding (mother) contraindication 413712001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.96 acidic
pKa2 13.08 acidic
pKa3 13.86 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA topoisomerase 2-alpha Enzyme INHIBITOR IC50 7.30 IUPHAR CHEMBL
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor WOMBAT-PK
Canalicular multispecific organic anion transporter 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 6 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
Canalicular multispecific organic anion transporter 1 Transporter Km 3.21 WOMBAT-PK
Multidrug resistance protein 1 Transporter Ki 3.28 WOMBAT-PK
Arachidonate 15-lipoxygenase Enzyme IC50 5.50 DRUG MATRIX

External reference:

IDSource
4018141 VUID
N0000146478 NUI
D00125 KEGG_DRUG
4018141 VANDF
C0015133 UMLSCUI
CHEBI:4911 CHEBI
EVP PDB_CHEM_ID
CHEMBL44657 ChEMBL_ID
DB00773 DRUGBANK_ID
CHEMBL1200645 ChEMBL_ID
D005047 MESH_DESCRIPTOR_UI
36462 PUBCHEM_CID
6815 IUPHAR_LIGAND_ID
3835 INN_ID
6PLQ3CP4P3 UNII
220347 RXNORM
4209 MMSL
4709 MMSL
6665 MMSL
d00230 MMSL
002674 NDDF
387316009 SNOMEDCT_US
56928005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9376 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9510 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9511 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9512 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0378-3266 CAPSULE 50 mg ORAL ANDA 24 sections
Toposar HUMAN PRESCRIPTION DRUG LABEL 1 0703-5653 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS ANDA 24 sections
Toposar HUMAN PRESCRIPTION DRUG LABEL 1 0703-5656 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS ANDA 24 sections
Toposar HUMAN PRESCRIPTION DRUG LABEL 1 0703-5657 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS ANDA 24 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 16729-114 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 16729-262 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 63323-104 INJECTION, SOLUTION 20 mg INTRAVENOUS ANDA 14 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 68001-265 INJECTION 20 mg INTRAVENOUS ANDA 22 sections