etoposide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1112	33419-42-0

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: etoposide etosid fytosid toposar zuyeyidal VP-16

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. Molecular weight: 588.56 Formula: C29H32O13 CLOGP: -0.11 LIPINSKI: 2 HAC: 13 HDO: 3 TPSA: 160.83 ALOGS: -2.78 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.22 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	38 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	6.30 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	52 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.18 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.50 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.12 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	5.70 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Nov. 10, 1983	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	2147.52	15.50	1239	41945	93388	46549490
Neutropenia	915.84	15.50	875	42309	142329	46500549
Bone marrow failure	727.80	15.50	410	42774	29259	46613619
Mucosal inflammation	696.23	15.50	439	42745	38537	46604341
Pancytopenia	610.57	15.50	555	42629	84503	46558375
Acute myeloid leukaemia	607.38	15.50	295	42889	15483	46627395
Product use in unapproved indication	516.78	15.50	520	42664	89753	46553125
Haemophagocytic lymphohistiocytosis	478.79	15.50	206	42978	8136	46634742
Myelodysplastic syndrome	470.75	15.50	248	42936	15463	46627415
Thrombocytopenia	462.83	15.50	577	42607	126004	46516874
Haematotoxicity	403.77	15.50	173	43011	6760	46636118
Ovarian failure	398.52	15.50	109	43075	1023	46641855
Off label use	332.52	15.50	932	42252	378909	46263969
Sepsis	307.69	15.50	493	42691	135521	46507357
Febrile bone marrow aplasia	278.16	15.50	133	43051	6729	46636149
Second primary malignancy	271.12	15.50	129	43055	6455	46636423
Disease progression	264.98	15.50	372	42812	90928	46551950
Tumour lysis syndrome	239.01	15.50	122	43062	7114	46635764
Multiple organ dysfunction syndrome	228.54	15.50	260	42924	51450	46591428
Posterior reversible encephalopathy syndrome	227.05	15.50	153	43031	14988	46627890
Venoocclusive liver disease	221.18	15.50	98	43086	4153	46638725
Malignant neoplasm progression	216.33	15.50	283	42901	64643	46578235
Maternal exposure before pregnancy	203.65	15.50	94	43090	4387	46638491
Septic shock	201.70	15.50	258	42926	57635	46585243
Neutropenic sepsis	188.29	15.50	126	43058	12198	46630680
Diffuse large B-cell lymphoma refractory	185.08	15.50	58	43126	906	46641972
Pain	183.90	15.50	107	43077	476841	46166037
Arthralgia	181.63	15.50	56	43128	364547	46278331
Aplasia	181.43	15.50	81	43103	3495	46639383
Teratoma	175.08	15.50	39	43145	136	46642742
Encephalopathy	169.30	15.50	181	43003	33408	46609470
Myelosuppression	168.74	15.50	99	43085	7604	46635274
Ovarian germ cell teratoma	168.60	15.50	35	43149	78	46642800
Stem cell transplant	165.13	15.50	62	43122	1704	46641174
Fall	164.85	15.50	50	43134	329047	46313831
Pyrexia	163.37	15.50	696	42488	348106	46294772
Drug hypersensitivity	148.24	15.50	24	43160	243801	46399077
Hepatosplenic T-cell lymphoma	142.69	15.50	43	43141	585	46642293
Venoocclusive disease	141.50	15.50	57	43127	1899	46640979
Neutrophil count decreased	141.03	15.50	187	42997	43239	46599639
Cytomegalovirus infection	136.92	15.50	122	43062	18022	46624856
Joint swelling	135.28	15.50	4	43180	166069	46476809
Diffuse large B-cell lymphoma recurrent	130.90	15.50	50	43134	1442	46641436
Leukopenia	129.30	15.50	229	42955	68114	46574764
Headache	121.68	15.50	159	43025	478193	46164685
Disease recurrence	121.47	15.50	115	43069	18356	46624522
Drug resistance	119.72	15.50	111	43073	17257	46625621
Platelet count decreased	115.30	15.50	273	42911	99751	46543127
Neutropenic colitis	114.64	15.50	51	43133	2181	46640697
Nasopharyngitis	114.57	15.50	7	43177	153991	46488887
Product dose omission issue	113.35	15.50	12	43172	168508	46474370
Cardiotoxicity	113.07	15.50	73	43111	6649	46636229
Aspergillus infection	111.43	15.50	73	43111	6817	46636061
Bacteraemia	110.29	15.50	97	43087	14082	46628796
Peripheral swelling	109.60	15.50	10	43174	158061	46484817
Ototoxicity	109.01	15.50	40	43144	1029	46641849
Diffuse large B-cell lymphoma	98.68	15.50	64	43120	5874	46637004
Pain in extremity	98.05	15.50	59	43125	258621	46384257
Fatigue	97.10	15.50	268	42916	608429	46034449
Malignant transformation	95.58	15.50	27	43157	288	46642590
Acute graft versus host disease	94.11	15.50	54	43130	3976	46638902
Premature menopause	92.98	15.50	32	43152	679	46642199
Dizziness	92.89	15.50	107	43077	340307	46302571
Pruritus	92.23	15.50	55	43129	242297	46400581
Insomnia	92.12	15.50	20	43164	164904	46477974
Oesophagitis	91.68	15.50	86	43098	13565	46629313
Alveolar soft part sarcoma	91.61	15.50	21	43163	86	46642792
Osteosarcoma	89.60	15.50	22	43162	128	46642750
Malaise	89.42	15.50	105	43079	331127	46311751
Graft versus host disease	87.96	15.50	62	43122	6526	46636352
Neoplasm progression	86.75	15.50	115	43069	26568	46616310
Pulmonary haemorrhage	86.35	15.50	61	43123	6444	46636434
Primary hypogonadism	86.23	15.50	22	43162	153	46642725
Neurotoxicity	85.63	15.50	83	43101	13634	46629244
Enterococcal infection	82.43	15.50	61	43123	6926	46635952
Anaemia	82.35	15.50	459	42725	255320	46387558
Anxiety	81.75	15.50	33	43151	181924	46460954
Cystitis haemorrhagic	81.42	15.50	47	43137	3500	46639378
Abdominal discomfort	81.10	15.50	20	43164	151145	46491733
Weight increased	78.64	15.50	27	43157	164446	46478432
Acute lymphocytic leukaemia	78.00	15.50	42	43142	2731	46640147
Nephroblastoma	77.91	15.50	19	43165	107	46642771
Acute lymphocytic leukaemia recurrent	77.04	15.50	38	43146	2057	46640821
Injection site pain	76.39	15.50	6	43178	107146	46535732
Nephropathy toxic	74.59	15.50	59	43125	7395	46635483
Human herpesvirus 6 infection	74.42	15.50	39	43145	2400	46640478
Bronchopulmonary aspergillosis	74.29	15.50	59	43125	7437	46635441
Musculoskeletal stiffness	74.25	15.50	4	43180	97989	46544889
Colitis	72.99	15.50	127	43057	37220	46605658
Teratoma benign	72.45	15.50	16	43168	53	46642825
Complications of bone marrow transplant	69.25	15.50	23	43161	436	46642442
Cytomegalovirus viraemia	68.91	15.50	46	43138	4432	46638446
Asthma	68.54	15.50	4	43180	91538	46551340
Cytopenia	68.26	15.50	57	43127	7711	46635167
Retinoblastoma	66.91	15.50	17	43167	116	46642762
Rash	66.03	15.50	145	43039	356367	46286511
Urticaria	64.40	15.50	15	43169	117877	46525001
Fungaemia	64.09	15.50	33	43151	1958	46640920
Leukoencephalopathy	63.71	15.50	42	43142	3962	46638916
Gene mutation	63.02	15.50	27	43157	1053	46641825
Enterobacter infection	62.84	15.50	32	43152	1855	46641023
Muscle spasms	62.78	15.50	18	43166	123095	46519783
Capillary leak syndrome	62.68	15.50	32	43152	1865	46641013
White blood cell count decreased	61.01	15.50	235	42949	111996	46530882
Thrombotic microangiopathy	60.97	15.50	55	43129	8251	46634627
Clostridium difficile colitis	60.36	15.50	80	43104	18473	46624405
Acute promyelocytic leukaemia	60.34	15.50	25	43159	896	46641982
Epstein-Barr virus infection	60.07	15.50	50	43134	6734	46636144
Choriocarcinoma	59.21	15.50	15	43169	101	46642777
Feeling abnormal	58.95	15.50	21	43163	125039	46517839
Gait disturbance	58.03	15.50	31	43153	145232	46497646
Lymphopenia	57.73	15.50	71	43113	15222	46627656
Disseminated intravascular coagulation	57.34	15.50	79	43105	18926	46623952
Cervix disorder	56.97	15.50	20	43164	451	46642427
Overdose	55.64	15.50	13	43171	101966	46540912
BK virus infection	55.60	15.50	34	43150	2815	46640063
Drug intolerance	55.00	15.50	34	43150	147015	46495863
Bronchitis	54.95	15.50	15	43169	105964	46536914
Depression	54.92	15.50	46	43138	170058	46472820
Human bocavirus infection	54.91	15.50	18	43166	327	46642551
Candida infection	54.80	15.50	84	43100	22156	46620722
Large intestinal ulcer perforation	54.76	15.50	13	43171	64	46642814
Acute myeloid leukaemia recurrent	53.36	15.50	26	43158	1370	46641508
Arthropathy	52.15	15.50	8	43176	84692	46558186
JC virus infection	51.92	15.50	27	43157	1635	46641243
Myeloid leukaemia	51.60	15.50	17	43167	314	46642564
T-cell lymphoma	51.33	15.50	20	43164	609	46642269
Graft versus host disease in skin	50.73	15.50	30	43154	2337	46640541
Neoplasm recurrence	50.65	15.50	30	43154	2343	46640535
Secondary immunodeficiency	48.92	15.50	22	43162	965	46641913
Progressive multifocal leukoencephalopathy	48.29	15.50	56	43128	11290	46631588
Injection site erythema	48.25	15.50	6	43178	74421	46568457
Deafness	47.29	15.50	66	43118	16002	46626876
Systemic candida	46.81	15.50	30	43154	2697	46640181
Hospitalisation	46.75	15.50	3	43181	63382	46579496
Myalgia	46.66	15.50	28	43156	123060	46519818
Leukaemia	46.30	15.50	32	43152	3263	46639615
Post transplant lymphoproliferative disorder	46.24	15.50	34	43150	3822	46639056
Pleural effusion	46.13	15.50	175	43009	82777	46560101
Epstein-Barr virus associated lymphoproliferative disorder	46.13	15.50	24	43160	1455	46641423
Acute respiratory distress syndrome	46.06	15.50	77	43107	21845	46621033
Abdominal pain upper	46.03	15.50	40	43144	145265	46497613
Herpes simplex	45.63	15.50	44	43140	7179	46635699
Klebsiella sepsis	45.60	15.50	23	43161	1306	46641572
Renal tubular disorder	44.51	15.50	28	43156	2437	46640441
Acute graft versus host disease in skin	44.36	15.50	30	43154	2952	46639926
Drug abuse	43.95	15.50	4	43180	63404	46579474
Encephalitis viral	43.93	15.50	24	43160	1606	46641272
Arthritis	43.91	15.50	9	43175	77307	46565571
Blood culture positive	43.62	15.50	35	43149	4477	46638401
Adenovirus infection	43.37	15.50	29	43155	2801	46640077
Refractory anaemia with an excess of blasts	43.33	15.50	16	43168	419	46642459
Varicella zoster virus infection	43.28	15.50	27	43157	2316	46640562
Amenorrhoea	43.15	15.50	47	43137	8848	46634030
Leukaemia recurrent	43.01	15.50	22	43162	1287	46641591
Mesenteric abscess	42.45	15.50	11	43173	82	46642796
Ascites	42.24	15.50	100	43084	36484	46606394
Migraine	42.24	15.50	7	43177	70019	46572859
Superior vena cava syndrome	42.15	15.50	17	43167	568	46642310
Neuropathy peripheral	41.97	15.50	181	43003	90712	46552166
Renal salt-wasting syndrome	41.97	15.50	13	43171	195	46642683
Cutaneous calcification	41.55	15.50	11	43173	90	46642788
Blood pressure increased	41.18	15.50	34	43150	126632	46516246
Dyspnoea	41.07	15.50	294	42890	515254	46127624
Suicidal ideation	40.61	15.50	3	43181	56379	46586499
Encephalitis cytomegalovirus	40.50	15.50	16	43168	506	46642372
Hypokalaemia	40.42	15.50	175	43009	87849	46555029
Hypersensitivity	40.09	15.50	48	43136	150273	46492605
Hepatitis B reactivation	40.00	15.50	22	43162	1492	46641386
Memory impairment	39.98	15.50	11	43173	77326	46565552
Infection	39.77	15.50	235	42949	133357	46509521
Sweat gland tumour	39.76	15.50	11	43173	108	46642770
T-cell type acute leukaemia	39.65	15.50	10	43174	66	46642812
Pneumonia fungal	39.64	15.50	32	43152	4128	46638750
Stomatitis	39.56	15.50	146	43038	68151	46574727
Recurrent cancer	39.55	15.50	23	43161	1736	46641142
Urinary tract infection	39.55	15.50	91	43093	220175	46422703
Gastrooesophageal reflux disease	39.53	15.50	10	43174	74334	46568544
Fungal oesophagitis	39.19	15.50	16	43168	552	46642326
Plasma cell leukaemia	39.05	15.50	20	43164	1173	46641705
Contusion	39.04	15.50	16	43168	87471	46555407
Influenza like illness	38.93	15.50	4	43180	57566	46585312
Listeria sepsis	38.78	15.50	16	43168	567	46642311
Hyperhidrosis	38.78	15.50	17	43167	89291	46553587
Respiratory failure	38.68	15.50	182	43002	94634	46548244
Gastrointestinal fungal infection	38.63	15.50	13	43171	257	46642621
Nail pigmentation	38.49	15.50	12	43172	184	46642694
Chloroma	38.43	15.50	12	43172	185	46642693
Medulloblastoma recurrent	38.31	15.50	10	43174	77	46642801
Bacterial infection	38.20	15.50	60	43124	16156	46626722
Swelling	37.38	15.50	36	43148	124475	46518403
Enterococcal sepsis	36.86	15.50	20	43164	1320	46641558
Nasal abscess	36.82	15.50	11	43173	145	46642733
Back pain	36.72	15.50	88	43096	209951	46432927
Epstein Barr virus positive mucocutaneous ulcer	36.01	15.50	12	43172	230	46642648
Blood glucose increased	35.84	15.50	11	43173	72002	46570876
Oedema peripheral	35.59	15.50	58	43126	159648	46483230
Klebsiella infection	35.50	15.50	37	43147	6625	46636253
Unmasking of previously unidentified disease	35.30	15.50	16	43168	715	46642163
Angiocentric lymphoma	35.08	15.50	14	43170	455	46642423
Abdominal compartment syndrome	34.99	15.50	15	43169	586	46642292
Myocardial infarction	34.48	15.50	24	43160	97504	46545374
Clostridium bacteraemia	34.29	15.50	11	43173	186	46642692
Palpitations	34.27	15.50	23	43161	95236	46547642
Hair follicle tumour benign	34.22	15.50	13	43171	369	46642509
Staphylococcal infection	34.19	15.50	91	43093	35680	46607198
Pneumatosis intestinalis	34.07	15.50	22	43162	2003	46640875
Therapeutic product effect decreased	33.90	15.50	17	43167	82584	46560294
Klebsiella bacteraemia	33.60	15.50	18	43166	1158	46641720
Oesophageal candidiasis	33.46	15.50	32	43152	5168	46637710
Alopecia	33.45	15.50	62	43122	162352	46480526
Staphylococcal sepsis	33.44	15.50	38	43146	7494	46635384
Bone marrow transplant	33.42	15.50	15	43169	655	46642223
Pulmonary alveolar haemorrhage	33.42	15.50	29	43155	4133	46638745
Vision blurred	33.32	15.50	16	43168	79692	46563186
Weight decreased	33.28	15.50	93	43091	210756	46432122
Cardiomyopathy acute	33.19	15.50	11	43173	207	46642671
Hepatosplenomegaly	32.91	15.50	23	43161	2387	46640491
Sinus polyp	32.80	15.50	12	43172	306	46642572
Leukoerythroblastosis	32.52	15.50	11	43173	221	46642657
Subdural hygroma	32.52	15.50	11	43173	221	46642657
Escherichia bacteraemia	32.33	15.50	24	43160	2737	46640141
Hypogammaglobulinaemia	32.25	15.50	32	43152	5406	46637472
Hepatitis B	32.24	15.50	27	43157	3666	46639212
Inappropriate schedule of product administration	32.23	15.50	10	43174	65003	46577875
White blood cell count abnormal	31.93	15.50	31	43153	5101	46637777
Mucocutaneous ulceration	31.92	15.50	10	43174	156	46642722
Loss of personal independence in daily activities	31.76	15.50	7	43177	57176	46585702
Stress	31.43	15.50	5	43179	51546	46591332
Tumour necrosis	31.33	15.50	15	43169	760	46642118
Gastroenteritis norovirus	31.28	15.50	19	43165	1554	46641324
Incorrect dose administered	31.22	15.50	3	43181	45547	46597331
Staphylococcal bacteraemia	31.22	15.50	30	43154	4874	46638004
Musculoskeletal pain	31.00	15.50	13	43171	70115	46572763
Therapy non-responder	30.91	15.50	96	43088	41056	46601822
Respiratory distress	30.31	15.50	81	43103	31835	46611043
Fungal infection	30.16	15.50	77	43107	29443	46613435
Metastases to diaphragm	30.09	15.50	7	43177	31	46642847
Metastases to lung	30.09	15.50	43	43141	10653	46632225
Venous thrombosis	30.07	15.50	29	43155	4733	46638145
Loss of consciousness	29.45	15.50	34	43150	108204	46534674
Pseudomonal sepsis	29.45	15.50	20	43164	1982	46640896
Device related infection	29.32	15.50	62	43122	20979	46621899
Parainfluenzae virus infection	29.08	15.50	19	43165	1765	46641113
Sinusitis	29.03	15.50	47	43137	129721	46513157
Streptococcal bacteraemia	29.01	15.50	17	43167	1302	46641576
Bacterial sepsis	28.93	15.50	25	43159	3542	46639336
Pneumothorax	28.90	15.50	50	43134	14579	46628299
Respiratory symptom	28.84	15.50	20	43164	2050	46640828
Tremor	28.67	15.50	39	43145	115600	46527278
Epiphyses premature fusion	28.61	15.50	7	43177	40	46642838
Somnolence	28.61	15.50	64	43120	156457	46486421
Toxic encephalopathy	28.57	15.50	29	43155	5033	46637845
Pulmonary toxicity	28.54	15.50	28	43156	4665	46638213
Metastases to central nervous system	28.51	15.50	43	43141	11178	46631700
Renal failure	28.30	15.50	191	42993	113403	46529475
Listeriosis	28.20	15.50	16	43168	1153	46641725
Chronic graft versus host disease	28.19	15.50	22	43162	2703	46640175
Dry mouth	28.04	15.50	8	43176	54918	46587960
Drug clearance increased	28.01	15.50	8	43176	89	46642789
Respiratory syncytial virus infection	27.84	15.50	28	43156	4807	46638071
Sinoatrial block	27.61	15.50	14	43170	804	46642074
Hypoglycaemia	27.59	15.50	8	43176	54341	46588537
International normalised ratio increased	27.58	15.50	5	43179	46878	46596000
Ejection fraction decreased	27.52	15.50	55	43129	17882	46624996
Sleep disorder	27.51	15.50	5	43179	46790	46596088
Ocular vascular disorder	27.32	15.50	11	43173	366	46642512
Thymus enlargement	27.31	15.50	8	43176	98	46642780
Mucormycosis	27.01	15.50	20	43164	2272	46640606
Cytomegalovirus chorioretinitis	26.92	15.50	17	43167	1490	46641388
Aplastic anaemia	26.65	15.50	33	43151	7120	46635758
Chronic obstructive pulmonary disease	26.60	15.50	10	43174	57623	46585255
Delayed puberty	26.53	15.50	8	43176	109	46642769
Rhinovirus infection	26.53	15.50	24	43160	3612	46639266
Small cell lung cancer	26.49	15.50	17	43167	1532	46641346
Injection site reaction	26.29	15.50	6	43178	47843	46595035
Injection site pruritus	26.26	15.50	3	43181	39740	46603138
Tonsillar haemorrhage	26.10	15.50	9	43175	192	46642686
Paraneoplastic neurological syndrome	26.00	15.50	5	43179	6	46642872
Acute myelomonocytic leukaemia	25.59	15.50	9	43175	204	46642674
Injury	25.25	15.50	5	43179	44022	46598856
Histiocytic sarcoma	25.10	15.50	7	43177	71	46642807
Enteritis	24.91	15.50	31	43153	6724	46636154
Acute monocytic leukaemia	24.84	15.50	7	43177	74	46642804
Gastrointestinal toxicity	24.79	15.50	25	43159	4306	46638572
Myeloproliferative neoplasm	24.51	15.50	11	43173	480	46642398
Condition aggravated	24.50	15.50	130	43054	244922	46397956
Hypophosphataemia	24.32	15.50	32	43152	7335	46635543
Cerebrovascular accident	24.12	15.50	35	43149	101004	46541874
Metastases to bone marrow	24.12	15.50	9	43175	243	46642635
Necrotising gastritis	24.00	15.50	6	43178	38	46642840
Peripheral sensory neuropathy	23.86	15.50	30	43154	6573	46636305
Toxic neuropathy	23.68	15.50	10	43174	376	46642502
Neutrophil count abnormal	23.67	15.50	19	43165	2431	46640447
Spinal cord paralysis	23.61	15.50	6	43178	41	46642837
Cytogenetic abnormality	23.55	15.50	11	43173	527	46642351
Cytokine storm	23.54	15.50	9	43175	260	46642618
Glossodynia	23.52	15.50	6	43178	44367	46598511
Adverse drug reaction	23.51	15.50	6	43178	44356	46598522
Vena cava thrombosis	23.43	15.50	18	43166	2161	46640717
Pericardial effusion	23.42	15.50	64	43120	25479	46617399
Stenotrophomonas infection	23.39	15.50	16	43168	1604	46641274
Lower respiratory tract infection	23.11	15.50	11	43173	55078	46587800
Unevaluable event	23.07	15.50	7	43177	46168	46596710
Hypoaesthesia	23.05	15.50	47	43137	118822	46524056
Abortion spontaneous	22.95	15.50	6	43178	43640	46599238
Respiratory tract infection fungal	22.94	15.50	10	43174	407	46642471
Vulvovaginal inflammation	22.91	15.50	11	43173	561	46642317
Nasal congestion	22.79	15.50	8	43176	48105	46594773
Adrenocortical carcinoma	22.78	15.50	6	43178	48	46642830
Listeria encephalitis	22.64	15.50	8	43176	184	46642694
B-cell lymphoma recurrent	22.60	15.50	10	43174	422	46642456
Diabetes mellitus	22.58	15.50	9	43175	50056	46592822
Vertigo	22.45	15.50	10	43174	52038	46590840
Vulvovaginitis	22.42	15.50	9	43175	297	46642581
Metastases to lymph nodes	22.19	15.50	29	43155	6602	46636276
Viral haemorrhagic cystitis	22.19	15.50	11	43173	602	46642276
Acquired gene mutation	22.14	15.50	11	43173	605	46642273
Iris atrophy	22.06	15.50	6	43178	55	46642823
Radiation pneumonitis	22.00	15.50	14	43170	1243	46641635
Urinary tract infection bacterial	21.95	15.50	23	43161	4142	46638736
Genotoxicity	21.91	15.50	5	43179	20	46642858
Ependymoma	21.87	15.50	6	43178	57	46642821
Metastases to spleen	21.84	15.50	7	43177	118	46642760
Neck pain	21.78	15.50	12	43172	55294	46587584
Congenital retinoblastoma	21.71	15.50	5	43179	21	46642857
Paranasal sinus mucosal hypertrophy	21.71	15.50	5	43179	21	46642857
Burning sensation	21.71	15.50	7	43177	44404	46598474
Follicular thyroid cancer	21.68	15.50	6	43178	59	46642819
Splenomegaly	21.65	15.50	35	43149	9653	46633225
Plasma cell myeloma	21.62	15.50	90	43094	44388	46598490
Suicide attempt	21.58	15.50	12	43172	55024	46587854
Retroperitoneal abscess	21.57	15.50	7	43177	123	46642755
Pseudomonas infection	21.47	15.50	35	43149	9723	46633155
Metastasis	21.29	15.50	23	43161	4289	46638589
Retinal pigment epitheliopathy	21.23	15.50	8	43176	222	46642656
Primary mediastinal large B-cell lymphoma recurrent	21.07	15.50	6	43178	66	46642812
Gliosis	20.93	15.50	8	43176	231	46642647
Depressed mood	20.84	15.50	3	43181	33316	46609562
Neutropenic infection	20.73	15.50	13	43171	1125	46641753
Congestive cardiomyopathy	20.72	15.50	26	43158	5687	46637191
Serum ferritin increased	20.70	15.50	25	43159	5258	46637620
Trichosporon infection	20.61	15.50	8	43176	241	46642637
Ganglioneuroma	20.59	15.50	7	43177	143	46642735
Blood stem cell transplant failure	20.36	15.50	7	43177	148	46642730
Lung infiltration	20.29	15.50	42	43142	14001	46628877
Ewing's sarcoma	20.29	15.50	4	43180	6	46642872
Pneumocystis jirovecii pneumonia	20.17	15.50	44	43140	15204	46627674
Blood cholesterol increased	20.11	15.50	6	43178	40007	46602871
VIth nerve paresis	20.09	15.50	6	43178	79	46642799
Discomfort	20.07	15.50	9	43175	46661	46596217
Radiation oesophagitis	20.04	15.50	8	43176	260	46642618
Gastrointestinal mucosal disorder	20.00	15.50	11	43173	746	46642132
Enterobacter bacteraemia	19.98	15.50	8	43176	262	46642616
Vaccination failure	19.88	15.50	6	43178	82	46642796
Wrong technique in product usage process	19.76	15.50	13	43171	54409	46588469
Therapy partial responder	19.74	15.50	23	43161	4659	46638219
Central nervous system lymphoma	19.58	15.50	13	43171	1241	46641637
Metastases to breast	19.51	15.50	8	43176	279	46642599
Plasmacytoma	19.36	15.50	17	43167	2460	46640418
Enterocolitis	19.14	15.50	26	43158	6142	46636736
Clostridium colitis	19.05	15.50	15	43169	1867	46641011
Oral fungal infection	19.03	15.50	17	43167	2517	46640361
Balance disorder	18.95	15.50	19	43165	64502	46578376
Fluid retention	18.79	15.50	12	43172	51034	46591844
Hypomagnesaemia	18.74	15.50	54	43130	22156	46620722
B precursor type acute leukaemia	18.69	15.50	7	43177	191	46642687
Lymphoma	18.68	15.50	33	43151	9780	46633098
Pulmonary vascular disorder	18.58	15.50	8	43176	316	46642562
Gestational trophoblastic tumour	18.56	15.50	5	43179	44	46642834
Product quality issue	18.55	15.50	5	43179	35643	46607235
Mucosal erosion	18.30	15.50	13	43171	1385	46641493
Refractory cancer	18.17	15.50	5	43179	48	46642830
Transdifferentiation of neoplasm	18.17	15.50	4	43180	13	46642865
Vascular compression	18.05	15.50	6	43178	114	46642764
Amnesia	17.95	15.50	8	43176	41623	46601255
Neuroblastoma	17.90	15.50	5	43179	51	46642827
Peripheral motor neuropathy	17.66	15.50	13	43171	1463	46641415
Impaired healing	17.59	15.50	6	43178	36737	46606141
Engraft failure	17.56	15.50	8	43176	362	46642516
Hypoglossal nerve paresis	17.49	15.50	6	43178	126	46642752
Rectal fissure	17.49	15.50	9	43175	533	46642345
Cardiopulmonary failure	17.12	15.50	19	43165	3650	46639228
Respiratory arrest	17.12	15.50	5	43179	33811	46609067
Carcinoid crisis	17.10	15.50	7	43177	243	46642635
Surgery	17.08	15.50	3	43181	28782	46614096
Coronary artery disease	17.07	15.50	5	43179	33747	46609131
Constipation	17.03	15.50	93	43091	174004	46468874
B-cell lymphoma	17.02	15.50	18	43166	3276	46639602
Myelopathy	16.98	15.50	16	43168	2536	46640342
Salivary gland cancer	16.98	15.50	6	43178	138	46642740
Lung consolidation	16.71	15.50	19	43165	3748	46639130
Rhabdomyolysis	16.63	15.50	9	43175	41900	46600978
Cardiomyopathy	16.49	15.50	42	43142	16031	46626847
Drug clearance decreased	16.35	15.50	11	43173	1073	46641805
Schistocytosis	16.33	15.50	4	43180	23	46642855
Streptococcal sepsis	16.27	15.50	13	43171	1652	46641226
Chest pain	16.27	15.50	96	43088	176228	46466650
Meningoencephalitis bacterial	16.27	15.50	5	43179	73	46642805
Dry eye	16.26	15.50	4	43180	30318	46612560
Intra-abdominal haemorrhage	16.26	15.50	15	43169	2315	46640563
Product administered to patient of inappropriate age	16.24	15.50	16	43168	2680	46640198
Blood creatine phosphokinase increased	16.21	15.50	3	43181	27721	46615157
Gastroenteritis cryptosporidial	16.20	15.50	5	43179	74	46642804
Rhabdomyosarcoma recurrent	16.19	15.50	4	43180	24	46642854
Odynophagia	16.18	15.50	25	43159	6637	46636241
Flagellate dermatitis	16.15	15.50	6	43178	160	46642718
Hyperkalaemia	15.99	15.50	14	43170	50695	46592183
Low cardiac output syndrome	15.99	15.50	7	43177	288	46642590
Glioblastoma multiforme	15.94	15.50	10	43174	866	46642012
Hypoxia	15.92	15.50	92	43092	51746	46591132
Sinusitis fungal	15.92	15.50	10	43174	868	46642010
Osteosarcoma metastatic	15.91	15.50	4	43180	26	46642852
Platelet count abnormal	15.86	15.50	16	43168	2756	46640122
Pneumonia klebsiella	15.83	15.50	14	43170	2045	46640833
Osteonecrosis of jaw	15.82	15.50	6	43178	34396	46608482
Traumatic lung injury	15.79	15.50	12	43172	1418	46641460
Vomiting	15.71	15.50	538	42646	452256	46190622
Pneumonia respiratory syncytial viral	15.62	15.50	9	43175	668	46642210

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Febrile neutropenia	2438.96	13.73	1883	58563	104810	29787222
Neutropenia	877.11	13.73	1182	59264	127358	29764674
Bone marrow failure	661.70	13.73	519	59927	29266	29862766
Mucosal inflammation	644.50	13.73	516	59930	29978	29862054
Acute myeloid leukaemia	601.70	13.73	402	60044	17604	29874428
Product use in unapproved indication	571.79	13.73	723	59723	72970	29819062
Pancytopenia	560.38	13.73	770	59676	84282	29807750
Myelodysplastic syndrome	489.22	13.73	360	60086	18418	29873614
Thrombocytopenia	435.83	13.73	895	59551	136149	29755883
Off label use	433.95	13.73	1291	59155	247999	29644033
Venoocclusive liver disease	333.54	13.73	192	60254	6421	29885611
Haematotoxicity	305.49	13.73	177	60269	5993	29886039
Second primary malignancy	284.95	13.73	171	60275	6185	29885847
Myelosuppression	272.55	13.73	175	60271	7147	29884885
Malignant neoplasm progression	259.13	13.73	497	59949	71790	29820242
Febrile bone marrow aplasia	240.03	13.73	168	60278	7929	29884103
Sepsis	229.19	13.73	732	59714	145663	29746369
Haemophagocytic lymphohistiocytosis	222.31	13.73	173	60273	9618	29882414
Tumour lysis syndrome	218.10	13.73	192	60254	12693	29879339
Septic shock	209.32	13.73	422	60024	63185	29828847
Leukopenia	187.63	13.73	375	60071	55784	29836248
Fall	178.48	13.73	72	60374	181800	29710232
Neoplasm progression	165.67	13.73	193	60253	17830	29874202
Neutropenic sepsis	165.65	13.73	156	60290	11253	29880779
Disease progression	158.66	13.73	435	60011	79439	29812593
Diffuse large B-cell lymphoma recurrent	150.84	13.73	77	60369	2015	29890017
Neutrophil count decreased	144.76	13.73	286	60160	42168	29849864
Pyrexia	140.79	13.73	1045	59401	293444	29598588
Product dose omission issue	137.65	13.73	13	60433	91618	29800414
Diffuse large B-cell lymphoma	137.01	13.73	119	60327	7722	29884310
Malignant transformation	136.00	13.73	52	60394	661	29891371
Fatigue	135.38	13.73	278	60168	320395	29571637
Bronchopulmonary aspergillosis	132.50	13.73	143	60303	12141	29879891
Cardiotoxicity	131.77	13.73	92	60354	4322	29887710
Diffuse large B-cell lymphoma refractory	131.66	13.73	52	60394	725	29891307
Posterior reversible encephalopathy syndrome	130.13	13.73	121	60325	8586	29883446
Venoocclusive disease	127.39	13.73	74	60372	2516	29889516
Aspergillus infection	126.45	13.73	128	60318	10086	29881946
Aplasia	124.87	13.73	86	60360	3951	29888081
Dizziness	124.50	13.73	126	60320	194783	29697249
Stem cell transplant	124.07	13.73	68	60378	2063	29889969
Stomatitis	122.11	13.73	247	60199	37032	29855000
Cytopenia	121.98	13.73	114	60332	8142	29883890
Neoplasm recurrence	109.87	13.73	60	60386	1807	29890225
Overdose	109.73	13.73	19	60427	84318	29807714
Acute graft versus host disease	108.56	13.73	92	60354	5772	29886260
Depression	108.02	13.73	25	60421	90412	29801620
Therapy partial responder	108.01	13.73	76	60370	3615	29888417
Insomnia	107.20	13.73	28	60418	93308	29798724
Malaise	98.73	13.73	115	60331	166847	29725185
Cystitis haemorrhagic	96.71	13.73	79	60367	4708	29887324
Encephalopathy	95.65	13.73	205	60241	32000	29860032
Acute lymphocytic leukaemia	89.30	13.73	63	60383	3009	29889023
Arthralgia	88.66	13.73	86	60360	135705	29756327
Drug interaction	88.31	13.73	168	60278	199400	29692632
Disease recurrence	85.18	13.73	123	60323	14038	29877994
Death	85.02	13.73	402	60044	356881	29535151
Neutropenic colitis	84.70	13.73	54	60392	2176	29889856
Neurotoxicity	84.46	13.73	118	60328	13064	29878968
Pain	83.90	13.73	137	60309	172504	29719528
Rash	83.62	13.73	163	60283	191726	29700306
Peripheral swelling	83.40	13.73	12	60434	61062	29830970
Tremor	82.08	13.73	25	60421	75338	29816694
Fungal infection	81.61	13.73	118	60328	13482	29878550
Joint swelling	81.45	13.73	3	60443	46943	29845089
Cytomegalovirus infection	81.27	13.73	160	60286	23514	29868518
Colitis	81.18	13.73	187	60259	30633	29861399
Anxiety	81.07	13.73	40	60406	89831	29802201
Bacteraemia	80.55	13.73	126	60320	15434	29876598
Anaemia	80.48	13.73	704	59742	207288	29684744
Blood pressure increased	79.91	13.73	23	60423	71905	29820127
Sweat gland tumour	77.37	13.73	30	60416	397	29891635
Cardiac failure congestive	76.99	13.73	37	60409	84370	29807662
Multiple organ dysfunction syndrome	75.24	13.73	290	60156	63197	29828835
Respiratory failure	73.17	13.73	398	60048	100244	29791788
Anaplastic lymphoma kinase gene mutation	70.61	13.73	20	60426	88	29891944
Coronary artery disease	69.69	13.73	9	60437	49703	29842329
Myocardial infarction	66.47	13.73	94	60352	125531	29766501
Progressive multifocal leukoencephalopathy	65.83	13.73	86	60360	8927	29883105
Chloroma	62.35	13.73	26	60420	420	29891612
Pulmonary toxicity	62.21	13.73	60	60386	4456	29887576
Lymphopenia	60.50	13.73	101	60345	13062	29878970
Systemic mycosis	60.48	13.73	35	60411	1181	29890851
Adenovirus infection	59.35	13.73	57	60389	4211	29887821
Blood glucose increased	59.18	13.73	25	60421	61505	29830527
Hepatitis B	59.10	13.73	67	60379	6005	29886027
Candida infection	59.10	13.73	109	60337	15253	29876779
Acute promyelocytic leukaemia	59.09	13.73	27	60419	549	29891483
Pruritus	59.07	13.73	92	60354	118112	29773920
Nasopharyngitis	58.08	13.73	23	60423	58826	29833206
Enterococcal bacteraemia	58.07	13.73	36	60410	1380	29890652
Weight decreased	57.55	13.73	138	60308	150783	29741249
Chronic graft versus host disease	57.26	13.73	55	60391	4064	29887968
White blood cell count decreased	57.01	13.73	326	60120	83621	29808411
Epstein-Barr virus infection	56.96	13.73	69	60377	6637	29885395
Weight increased	56.78	13.73	41	60405	74872	29817160
Epstein-Barr virus associated lymphoproliferative disorder	56.26	13.73	38	60408	1690	29890342
Drug resistance	56.17	13.73	125	60321	20008	29872024
Aggression	56.02	13.73	5	60441	36902	29855130
Hypoglycaemia	55.34	13.73	17	60429	50964	29841068
Headache	55.31	13.73	186	60260	182120	29709912
Osteosarcoma	54.97	13.73	19	60427	177	29891855
Acute graft versus host disease in skin	54.81	13.73	56	60390	4460	29887572
Chest pain	54.64	13.73	96	60350	117531	29774501
Musculoskeletal stiffness	54.08	13.73	5	60441	35876	29856156
Azoospermia	53.67	13.73	23	60423	399	29891633
Enterococcal infection	53.24	13.73	74	60372	8150	29883882
Somnolence	52.57	13.73	71	60375	96692	29795340
Bacterial sepsis	52.50	13.73	57	60389	4869	29887163
Oedema peripheral	52.27	13.73	83	60363	105749	29786283
Myalgia	51.82	13.73	47	60399	76620	29815412
Renal tubular disorder	51.75	13.73	57	60389	4949	29887083
Feeling abnormal	51.55	13.73	25	60421	56731	29835301
Inappropriate schedule of product administration	51.53	13.73	9	60437	39719	29852313
Vena cava thrombosis	51.42	13.73	30	60416	1028	29891004
Neuropathy peripheral	51.37	13.73	279	60167	70196	29821836
Pneumonitis	50.94	13.73	146	60300	27308	29864724
Ameloblastoma	50.75	13.73	15	60431	79	29891953
Nephropathy toxic	50.73	13.73	83	60363	10556	29881476
Blood stem cell transplant failure	50.24	13.73	22	60424	403	29891629
Psoriasis	50.22	13.73	12	60434	42494	29849538
Staphylococcal bacteraemia	50.08	13.73	65	60381	6703	29885329
Cytomegalovirus chorioretinitis	49.96	13.73	46	60400	3222	29888810
Pulmonary vascular disorder	49.87	13.73	21	60425	348	29891684
Cerebrovascular accident	49.80	13.73	57	60389	83420	29808612
Muscle spasms	49.77	13.73	35	60411	64803	29827229
Asthma	49.63	13.73	7	60439	36167	29855865
Ependymoma	48.81	13.73	14	60432	65	29891967
Small cell lung cancer	48.81	13.73	36	60410	1844	29890188
Neuroblastoma	48.01	13.73	18	60428	216	29891816
Rheumatoid arthritis	47.95	13.73	12	60434	41185	29850847
Hyperkalaemia	47.62	13.73	38	60408	65972	29826060
B-cell lymphoma recurrent	47.32	13.73	24	60422	619	29891413
Diaphragm muscle weakness	47.01	13.73	14	60432	76	29891956
Hepatitis B reactivation	46.93	13.73	42	60404	2835	29889197
Pneumocystis jirovecii pneumonia	46.31	13.73	105	60341	17015	29875017
Acute respiratory distress syndrome	45.67	13.73	127	60319	23345	29868687
Graft versus host disease	45.47	13.73	77	60369	10073	29881959
Rhabdomyolysis	45.37	13.73	37	60409	63543	29828489
Platelet count decreased	45.02	13.73	367	60079	105762	29786270
Klebsiella sepsis	44.85	13.73	33	60413	1684	29890348
Medulloblastoma recurrent	44.71	13.73	13	60433	64	29891968
Clostridium difficile colitis	44.66	13.73	87	60359	12681	29879351
Hospitalisation	44.26	13.73	17	60429	44302	29847730
Retinal haemorrhage	43.91	13.73	51	60395	4692	29887340
T-cell type acute leukaemia	43.84	13.73	16	60430	177	29891855
Fusarium infection	43.51	13.73	27	60419	1037	29890995
Pain in extremity	43.42	13.73	99	60347	110122	29781910
Pneumonia klebsiella	42.62	13.73	38	60408	2552	29889480
Chronic obstructive pulmonary disease	42.37	13.73	20	60426	46106	29845926
Urinary tract infection	42.11	13.73	52	60394	73607	29818425
Papillary thyroid cancer	41.67	13.73	22	60424	618	29891414
Refractory cancer	41.63	13.73	14	60432	119	29891913
Hypogammaglobulinaemia	41.32	13.73	52	60394	5200	29886832
Drug hypersensitivity	40.63	13.73	47	60399	68472	29823560
Blood creatine phosphokinase increased	40.30	13.73	19	60427	43829	29848203
Influenza like illness	40.15	13.73	3	60443	25602	29866430
Lymphadenopathy	39.88	13.73	124	60322	24252	29867780
Gait disturbance	39.47	13.73	56	60390	74721	29817311
Incorrect dose administered	39.34	13.73	8	60438	31678	29860354
Escherichia bacteraemia	38.93	13.73	38	60408	2864	29889168
Central nervous system fungal infection	38.68	13.73	16	60430	253	29891779
Recurrent cancer	38.62	13.73	26	60420	1150	29890882
Systemic candida	38.59	13.73	37	60409	2727	29889305
Agranulocytosis	38.13	13.73	114	60332	21828	29870204
Hallucination	36.97	13.73	27	60419	49032	29843000
Thrombotic microangiopathy	36.84	13.73	64	60382	8546	29883486
Metastasis	36.62	13.73	39	60407	3259	29888773
Engraftment syndrome	36.26	13.73	22	60424	811	29891221
Haematochezia	36.09	13.73	12	60434	34210	29857822
Pulmonary arteriopathy	36.01	13.73	11	60435	66	29891966
Testicular germ cell cancer metastatic	35.87	13.73	11	60435	67	29891965
Drug reaction with eosinophilia and systemic symptoms	35.77	13.73	7	60439	28481	29863551
Hyperhidrosis	35.65	13.73	50	60396	67040	29824992
Sleep disorder	35.36	13.73	4	60442	24475	29867557
Arthritis	35.22	13.73	4	60442	24397	29867635
Balance disorder	34.81	13.73	15	60431	36478	29855554
Cytogenetic abnormality	34.64	13.73	21	60425	773	29891259
Ganglioneuroblastoma	34.45	13.73	9	60437	27	29892005
Vision blurred	34.21	13.73	21	60425	41795	29850237
Peripheral T-cell lymphoma unspecified	33.98	13.73	18	60428	509	29891523
Delayed puberty	33.94	13.73	13	60433	166	29891866
Unevaluable event	33.77	13.73	11	60435	31774	29860258
Nephrolithiasis	33.57	13.73	5	60441	24805	29867227
Mucormycosis	33.50	13.73	47	60399	5221	29886811
Cellulitis gangrenous	33.39	13.73	13	60433	174	29891858
Fanconi syndrome	33.16	13.73	28	60418	1747	29890285
Loss of consciousness	33.14	13.73	69	60377	79306	29812726
Osteonecrosis	33.08	13.73	89	60357	16046	29875986
Metastases to liver	33.04	13.73	74	60372	11891	29880141
Angioedema	33.01	13.73	14	60432	34370	29857662
Abdominal discomfort	32.85	13.73	30	60416	48761	29843271
Human herpesvirus 6 infection	32.76	13.73	29	60417	1929	29890103
Medulloblastoma	32.46	13.73	10	60436	62	29891970
Juvenile melanoma benign	32.06	13.73	10	60436	65	29891967
Escherichia infection	31.94	13.73	51	60395	6354	29885678
Bradycardia	31.76	13.73	52	60394	65474	29826558
Dyspnoea	31.32	13.73	479	59967	332816	29559216
Stenotrophomonas infection	31.13	13.73	26	60420	1598	29890434
Urticaria	30.73	13.73	39	60407	54567	29837465
Primitive neuroectodermal tumour	30.71	13.73	10	60436	76	29891956
Toxic encephalopathy	30.63	13.73	42	60404	4567	29887465
Carotid artery thrombosis	30.60	13.73	15	60431	359	29891673
Pancreatic neuroendocrine tumour metastatic	30.47	13.73	12	60434	166	29891866
Therapy non-responder	30.44	13.73	129	60317	29324	29862708
Extravasation	30.44	13.73	27	60419	1801	29890231
Acute lymphocytic leukaemia recurrent	30.43	13.73	32	60414	2635	29889397
Injury	30.29	13.73	4	60442	21727	29870305
Minimal residual disease	30.26	13.73	13	60433	227	29891805
Leukaemia recurrent	29.94	13.73	25	60421	1536	29890496
Salivary gland cancer	29.85	13.73	13	60433	235	29891797
Aortic thrombosis	29.58	13.73	18	60428	667	29891365
Back pain	29.50	13.73	107	60339	102489	29789543
Hepatotoxicity	29.40	13.73	92	60354	18053	29873979
Body height below normal	29.35	13.73	13	60433	245	29891787
Enteritis	29.22	13.73	50	60396	6595	29885437
Cardio-respiratory arrest	29.17	13.73	44	60402	57262	29834770
Rhabdomyosarcoma recurrent	29.14	13.73	10	60436	91	29891941
Teratoma	29.13	13.73	7	60439	13	29892019
Renal salt-wasting syndrome	29.04	13.73	11	60435	136	29891896
Eosinophilia	28.78	13.73	5	60441	22155	29869877
Nervous system disorder	28.74	13.73	74	60372	12995	29879037
Memory impairment	28.60	13.73	20	60426	37154	29854878
Embolism	28.56	13.73	51	60395	6958	29885074
Capillary leak syndrome	28.45	13.73	25	60421	1647	29890385
Aspiration bone marrow abnormal	28.21	13.73	10	60436	101	29891931
Metastases to retroperitoneum	28.11	13.73	12	60434	206	29891826
Electrocardiogram QT prolonged	27.95	13.73	19	60427	35816	29856216
Diabetes mellitus	27.87	13.73	26	60420	41839	29850193
Encephalitis enteroviral	27.87	13.73	11	60435	153	29891879
Metastases to lung	27.86	13.73	54	60392	7841	29884191
Hepatic infection fungal	27.81	13.73	11	60435	154	29891878
High-grade B-cell lymphoma	27.74	13.73	11	60435	155	29891877
Loss of personal independence in daily activities	27.66	13.73	5	60441	21530	29870502
Cardiac disorder	27.49	13.73	24	60422	39869	29852163
Intestinal atresia	27.24	13.73	9	60437	72	29891960
Pulmonary haemorrhage	26.96	13.73	59	60387	9333	29882699
Refractory anaemia with an excess of blasts	26.89	13.73	14	60432	382	29891650
Short stature	26.78	13.73	8	60438	44	29891988
Hepatic candidiasis	26.48	13.73	8	60438	46	29891986
Neutrophil count abnormal	26.33	13.73	22	60424	1353	29890679
Bacterial infection	26.30	13.73	70	60376	12540	29879492
Hypophosphataemia	26.22	13.73	54	60392	8191	29883841
Candida sepsis	26.20	13.73	20	60426	1079	29890953
Mantle cell lymphoma recurrent	26.02	13.73	14	60432	409	29891623
Cardiac arrest	25.92	13.73	98	60348	92752	29799280
Cytokine release syndrome	25.84	13.73	60	60386	9873	29882159
Abdominal pain upper	25.58	13.73	55	60391	62496	29829536
Device related infection	25.50	13.73	84	60362	16931	29875101
Bicytopenia	25.39	13.73	24	60422	1738	29890294
Trichosporon infection	25.27	13.73	16	60430	637	29891395
Pulmonary veno-occlusive disease	25.18	13.73	14	60432	437	29891595
Intussusception	25.14	13.73	15	60431	536	29891496
Graft versus host disease in gastrointestinal tract	25.12	13.73	31	60415	3038	29888994
Metastases to muscle	25.10	13.73	11	60435	202	29891830
Lactic acidosis	25.08	13.73	16	60430	31197	29860835
Metastases to central nervous system	24.71	13.73	49	60397	7235	29884797
Pneumocystis jirovecii infection	24.68	13.73	21	60425	1324	29890708
Hypoalbuminaemia	24.59	13.73	63	60383	11029	29881003
Pneumonia aspiration	24.52	13.73	24	60422	37756	29854276
Disseminated intravascular coagulation	24.39	13.73	99	60347	22072	29869960
Geotrichum infection	24.36	13.73	14	60432	466	29891566
Swelling	24.36	13.73	22	60424	35953	29856079
Hypertensive hydrocephalus	24.21	13.73	8	60438	64	29891968
Klebsiella infection	24.17	13.73	47	60399	6840	29885192
Gastrooesophageal reflux disease	23.97	13.73	18	60428	32237	29859795
Blood cholesterol increased	23.95	13.73	3	60443	16967	29875065
Contusion	23.84	13.73	17	60429	31263	29860769
Abnormal behaviour	23.70	13.73	11	60435	25612	29866420
Liver function test abnormal	23.35	13.73	17	60429	30933	29861099
Wheezing	23.34	13.73	17	60429	30921	29861111
Serotonin syndrome	23.31	13.73	4	60442	17887	29874145
Graft versus host disease in skin	23.29	13.73	31	60415	3276	29888756
Toxicity to various agents	23.22	13.73	237	60209	176946	29715086
Anaplastic large-cell lymphoma	23.10	13.73	10	60436	178	29891854
Carbamoyl phosphate synthetase deficiency	22.97	13.73	6	60440	18	29892014
Leukoencephalopathy	22.95	13.73	34	60412	3968	29888064
Papilloedema	22.93	13.73	26	60420	2330	29889702
Streptococcal bacteraemia	22.65	13.73	22	60424	1648	29890384
Dyskinesia	22.42	13.73	8	60438	21826	29870206
Plasma cell leukaemia	22.42	13.73	17	60429	908	29891124
Abdominal distension	22.40	13.73	36	60410	45673	29846359
Delayed engraftment	22.38	13.73	8	60438	83	29891949
Syncope	22.18	13.73	92	60354	84811	29807221
BK virus infection	22.11	13.73	35	60411	4329	29887703
Bronchitis	21.95	13.73	28	60418	39097	29852935
Gastrointestinal mucosal disorder	21.92	13.73	12	60434	363	29891669
Stomatitis necrotising	21.80	13.73	8	60438	90	29891942
Gallbladder empyema	21.64	13.73	7	60439	52	29891980
Erectile dysfunction	21.60	13.73	5	60441	18097	29873935
Lung infiltration	21.58	13.73	65	60381	12494	29879538
Myelopathy	21.58	13.73	23	60423	1924	29890108
Herpes simplex	21.52	13.73	35	60411	4429	29887603
Disturbance in attention	21.25	13.73	9	60437	22120	29869912
Heart rate decreased	21.04	13.73	8	60438	20986	29871046
Metastases to bone marrow	21.02	13.73	13	60433	496	29891536
Gastrointestinal toxicity	20.99	13.73	23	60423	1985	29890047
Visceral oedema	20.91	13.73	5	60441	9	29892023
Respiratory arrest	20.89	13.73	17	60429	29241	29862791
Traumatic lung injury	20.78	13.73	18	60428	1163	29890869
Seminoma	20.76	13.73	10	60436	230	29891802
Adrenocortical carcinoma	20.72	13.73	6	60440	29	29892003
Osteonecrosis of jaw	20.57	13.73	6	60440	18612	29873420
Basal cell naevus syndrome	20.56	13.73	6	60440	30	29892002
Paternal exposure timing unspecified	20.56	13.73	6	60440	30	29892002
Transformation to acute myeloid leukaemia	20.54	13.73	14	60432	632	29891400
Arrhythmia	20.47	13.73	22	60424	33147	29858885
Peripheral sensory neuropathy	20.38	13.73	40	60406	5861	29886171
Subdural haemorrhage	20.34	13.73	27	60419	2845	29889187
Treatment noncompliance	20.21	13.73	13	60433	25240	29866792
Streptococcal infection	20.15	13.73	35	60411	4673	29887359
Transient ischaemic attack	20.14	13.73	13	60433	25187	29866845
Neuroblastoma recurrent	20.08	13.73	7	60439	67	29891965
Mobility decreased	19.98	13.73	14	60432	25985	29866047
Burkitt's lymphoma	19.92	13.73	9	60437	178	29891854
Road traffic accident	19.81	13.73	5	60441	17066	29874966
Therapy responder	19.79	13.73	9	60437	181	29891851
Flatulence	19.75	13.73	6	60440	18123	29873909
Head injury	19.72	13.73	5	60441	17015	29875017
Influenza	19.60	13.73	36	60410	43362	29848670
Staphylococcal infection	19.59	13.73	116	60330	30108	29861924
Emotional distress	19.53	13.73	4	60442	15761	29876271
Intestinal perforation	19.52	13.73	49	60397	8470	29883562
Renal infarct	19.45	13.73	17	60429	1112	29890920
Flagellate dermatitis	19.39	13.73	5	60441	14	29892018
Atypical teratoid/rhabdoid tumour of CNS	19.39	13.73	5	60441	14	29892018
Pneumonia cytomegaloviral	19.37	13.73	26	60420	2770	29889262
Expanded disability status scale score increased	19.35	13.73	9	60437	191	29891841
Myeloid leukaemia	19.31	13.73	11	60435	360	29891672
Splenic infarction	19.24	13.73	21	60425	1804	29890228
Enterocolitis	19.19	13.73	42	60404	6645	29885387
Graft versus host disease in liver	19.12	13.73	16	60430	986	29891046
Staphylococcal sepsis	19.10	13.73	52	60394	9439	29882593
Blood culture positive	19.04	13.73	35	60411	4884	29887148
Autoimmune neutropenia	18.94	13.73	10	60436	281	29891751
Cerebral venous thrombosis	18.93	13.73	13	60433	594	29891438
Wrong technique in product usage process	18.86	13.73	21	60425	31134	29860898
Clostridium test positive	18.85	13.73	22	60424	2034	29889998
Escherichia sepsis	18.82	13.73	31	60415	3963	29888069
Premature ageing	18.67	13.73	7	60439	84	29891948
Peripheral T-cell lymphoma unspecified stage III	18.61	13.73	6	60440	44	29891988
Diverticulitis	18.60	13.73	6	60440	17439	29874593
Metastases to meninges	18.56	13.73	17	60429	1182	29890850
Acute myelomonocytic leukaemia	18.45	13.73	8	60438	143	29891889
Faeces discoloured	18.43	13.73	3	60443	13943	29878089
Dehydration	18.41	13.73	160	60286	123379	29768653
Adverse drug reaction	18.41	13.73	12	60434	23133	29868899
Blood pressure systolic increased	18.37	13.73	4	60442	15106	29876926
Cerebral venous sinus thrombosis	18.37	13.73	10	60436	299	29891733
Hyperlipidaemia	18.36	13.73	3	60443	13904	29878128
Blindness cortical	18.31	13.73	10	60436	301	29891731
Chromaturia	18.29	13.73	3	60443	13862	29878170
Therapeutic product effect decreased	18.27	13.73	19	60427	29057	29862975
Epstein-Barr viraemia	18.26	13.73	15	60431	901	29891131
Accidental overdose	18.26	13.73	7	60439	18268	29873764
Reticulocytosis	18.25	13.73	10	60436	303	29891729
Refractory cytopenia with multilineage dysplasia	18.10	13.73	8	60438	150	29891882
Arterial thrombosis	18.09	13.73	18	60428	1388	29890644
Ischaemic cerebral infarction	18.07	13.73	15	60431	914	29891118
Burns first degree	18.07	13.73	4	60442	4	29892028
Dry mouth	17.97	13.73	12	60434	22838	29869194
Vomiting	17.92	13.73	575	59871	219243	29672789
Chemotherapy	17.88	13.73	12	60434	528	29891504
Pneumomediastinum	17.83	13.73	20	60426	1771	29890261
Hypokalaemia	17.83	13.73	167	60279	50025	29842007
Pseudomonas infection	17.77	13.73	54	60392	10428	29881604
Lethargy	17.65	13.73	33	60413	39486	29852546
Pancreatitis	17.63	13.73	29	60417	36461	29855571
Metastases to lymph nodes	17.59	13.73	30	60416	3947	29888085
Gene mutation	17.54	13.73	14	60432	807	29891225
Amnesia	17.53	13.73	14	60432	24307	29867725
Pulmonary fibrosis	17.51	13.73	71	60375	15819	29876213
Human herpesvirus 8 infection	17.45	13.73	13	60433	676	29891356
Cerebral toxoplasmosis	17.40	13.73	18	60428	1454	29890578
Metastases to spleen	17.40	13.73	10	60436	333	29891699
Hyperbilirubinaemia	17.34	13.73	74	60372	16868	29875164
Psychotic disorder	17.32	13.73	11	60435	21504	29870528
Hirsutism	17.27	13.73	8	60438	168	29891864
Adenomatous polyposis coli	17.23	13.73	8	60438	169	29891863
Asthenia	17.17	13.73	329	60117	220961	29671071
Autoimmune haemolytic anaemia	17.14	13.73	30	60416	4029	29888003
Platelet transfusion	17.13	13.73	15	60431	983	29891049
Myelitis transverse	17.11	13.73	15	60431	985	29891047
International normalised ratio increased	17.11	13.73	45	60401	47694	29844338
Neuroendocrine tumour of the lung metastatic	17.08	13.73	7	60439	108	29891924
Swollen tongue	17.08	13.73	3	60443	13189	29878843
Guillain-Barre syndrome	17.01	13.73	34	60412	5049	29886983
Cardiomyopathy	16.96	13.73	68	60378	15075	29876957
Neoplasm	16.94	13.73	30	60416	4066	29887966
Laboratory test abnormal	16.90	13.73	7	60439	17435	29874597
Infected neoplasm	16.89	13.73	6	60440	61	29891971
Poikiloderma	16.89	13.73	8	60438	177	29891855
Angiodysplasia	16.82	13.73	11	60435	463	29891569
Inflammatory pseudotumour	16.66	13.73	5	60441	28	29892004
Speech disorder	16.58	13.73	15	60431	24497	29867535
Acanthamoeba infection	16.55	13.73	11	60435	476	29891556
Radiation oesophagitis	16.52	13.73	10	60436	367	29891665
Congenital hepatobiliary anomaly	16.51	13.73	5	60441	29	29892003
Herpes simplex reactivation	16.51	13.73	5	60441	29	29892003
Migraine	16.51	13.73	3	60443	12871	29879161
Intentional product use issue	16.50	13.73	128	60318	36312	29855720
Musculoskeletal pain	16.48	13.73	23	60423	30917	29861115
Renal disorder	16.47	13.73	14	60432	23570	29868462
Chronic myeloid leukaemia	16.40	13.73	23	60423	2554	29889478
Ototoxicity	16.38	13.73	17	60429	1379	29890653
Retinoblastoma	16.37	13.73	5	60441	30	29892002
Diabetes mellitus inadequate control	16.31	13.73	3	60443	12759	29879273
Pulmonary alveolar haemorrhage	16.30	13.73	39	60407	6542	29885490
Ewing's sarcoma	16.23	13.73	5	60441	31	29892001
Mucosal toxicity	16.22	13.73	8	60438	194	29891838
Chest discomfort	16.20	13.73	43	60403	45437	29846595
Hepatic cirrhosis	16.20	13.73	6	60440	15993	29876039
Pneumonia fungal	16.16	13.73	35	60411	5498	29886534
Cerebral artery occlusion	16.14	13.73	13	60433	759	29891273
Choriocarcinoma	15.96	13.73	5	60441	33	29891999
Product quality issue	15.96	13.73	9	60437	18765	29873267
Neuroendocrine carcinoma	15.95	13.73	10	60436	391	29891641
Paraparesis	15.81	13.73	19	60427	1812	29890220
Prostate cancer	15.80	13.73	15	60431	23942	29868090
Chronic myelomonocytic leukaemia	15.78	13.73	12	60434	644	29891388
Rectal haemorrhage	15.76	13.73	29	60417	34910	29857122
Iris atrophy	15.64	13.73	6	60440	77	29891955
Nasal congestion	15.64	13.73	9	60437	18557	29873475
Erythema ab igne	15.62	13.73	3	60443	0	29892032
Li-Fraumeni syndrome	15.62	13.73	3	60443	0	29892032
Decreased appetite	15.57	13.73	211	60235	149699	29742333
Delirium	15.57	13.73	37	60409	40594	29851438
Procalcitonin decreased	15.57	13.73	4	60442	11	29892021
Fibrinous bronchitis	15.57	13.73	4	60442	11	29892021
Histiocytic sarcoma	15.57	13.73	4	60442	11	29892021
Thyroid cancer	15.50	13.73	16	60430	1289	29890743
Clostridium colitis	15.50	13.73	16	60430	1289	29890743
Clostridium difficile infection	15.44	13.73	68	60378	15715	29876317
Angiocentric lymphoma	15.41	13.73	9	60437	309	29891723
Burning sensation	15.35	13.73	7	60439	16467	29875565
Cytomegalovirus viraemia	15.33	13.73	35	60411	5694	29886338
Mediastinum neoplasm	15.31	13.73	4	60442	12	29892020
Adenocarcinoma gastric	15.30	13.73	15	60431	1136	29890896
Myoclonus	15.25	13.73	4	60442	13308	29878724
Salivary gland cancer stage IV	15.24	13.73	5	60441	39	29891993
Cytomegalovirus infection reactivation	15.14	13.73	18	60428	1697	29890335
Vertigo	15.13	13.73	14	60432	22621	29869411
Cerebral artery stenosis	15.10	13.73	9	60437	321	29891711
Superior vena cava syndrome	15.08	13.73	10	60436	431	29891601
Testicular germ cell cancer	15.07	13.73	4	60442	13	29892019
Rash pruritic	15.04	13.73	14	60432	22558	29869474
Platelet count abnormal	14.94	13.73	21	60425	2336	29889696
Primary hypogonadism	14.91	13.73	6	60440	88	29891944
Acute myeloid leukaemia recurrent	14.89	13.73	17	60429	1535	29890497
Dry skin	14.88	13.73	14	60432	22440	29869592
Oesophagitis	14.86	13.73	53	60393	11118	29880914
Blastic plasmacytoid dendritic cell neoplasia	14.85	13.73	6	60440	89	29891943
Electrolyte imbalance	14.82	13.73	54	60392	11446	29880586
Blood glucose decreased	14.81	13.73	4	60442	13049	29878983
Neutropenic infection	14.78	13.73	14	60432	1016	29891016
Arachnoiditis	14.78	13.73	9	60437	334	29891698
Fungal sepsis	14.78	13.73	12	60434	709	29891323
5q minus syndrome	14.73	13.73	7	60439	156	29891876
Pneumonia adenoviral	14.73	13.73	7	60439	156	29891876
Non-Hodgkin's lymphoma unspecified histology aggressive	14.72	13.73	5	60441	44	29891988
Skin exfoliation	14.72	13.73	15	60431	23157	29868875
Hepatitis D	14.62	13.73	5	60441	45	29891987
Bone sarcoma	14.61	13.73	6	60440	93	29891939
Deafness	14.61	13.73	50	60396	10275	29881757
Recall phenomenon	14.50	13.73	11	60435	588	29891444
Lymphoma transformation	14.49	13.73	7	60439	162	29891870
Agitation	14.49	13.73	58	60388	54015	29838017
Mucoepidermoid carcinoma	14.43	13.73	4	60442	16	29892016
Adenoviral hepatitis	14.38	13.73	7	60439	165	29891867
Hepatic necrosis	14.34	13.73	27	60419	3836	29888196
Colony stimulating factor therapy	14.34	13.73	7	60439	166	29891866
Fungal endocarditis	14.26	13.73	7	60439	168	29891864
Hepatic steatosis	14.23	13.73	6	60440	14787	29877245
Meningioma	14.17	13.73	16	60430	1427	29890605
Surgery	14.16	13.73	3	60443	11548	29880484
Pleural effusion	14.16	13.73	219	60227	73847	29818185
Lower respiratory tract infection	14.09	13.73	20	60426	26694	29865338
Varicella zoster virus infection	14.09	13.73	15	60431	1253	29890779
Ewing's sarcoma recurrent	14.05	13.73	4	60442	18	29892014
Decorticate posture	14.05	13.73	4	60442	18	29892014
Hypertension	14.01	13.73	167	60279	121187	29770845
Confusional state	13.92	13.73	190	60256	134644	29757388
Sudden death	13.79	13.73	7	60439	15485	29876547

Pharmacologic Action:

Source	Code	Description
ATC	L01CB01	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Podophyllotoxin derivatives
FDA MoA	N0000000176	Topoisomerase Inhibitors
FDA EPC	N0000175609	Topoisomerase Inhibitor
CHEBI has role	CHEBI:35610	cytostatic
CHEBI has role	CHEBI:59517	dna synthesis inhibitors
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D000972	Antineoplastic Agents, Phytogenic
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D059005	Topoisomerase II Inhibitors

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Small cell carcinoma of lung	indication	254632001	DOID:5409
Malignant tumor of testis	indication	363449006	DOID:2998
Allogeneic bone marrow transplantation	off-label use	58390007
Ewing's sarcoma	off-label use	76909002	DOID:3369
Acute myeloid leukemia, disease	off-label use	91861009
Kaposi's sarcoma	off-label use	109385007
Diffuse non-Hodgkin's lymphoma, large cell	off-label use	109969005
Multiple myeloma	off-label use	109989006	DOID:9538
Hodgkin's disease	off-label use	118599009
Burkitt's lymphoma	off-label use	118617000
Non-small cell lung cancer	off-label use	254637007	DOID:3908
Osteosarcoma of bone	off-label use	307576001	DOID:3376
Malignant tumor of ovary	off-label use	363443007	DOID:2394
Neuroblastoma	off-label use	432328008	DOID:769
Neuroendocrine Prostate Carcinoma	off-label use
Progressive Diffuse Large B-Cell Lymphoma	off-label use
Testicular Germ Cell Tumor	off-label use
Ovarian Germ Cell Tumor Carcinoma	off-label use
Acute hemorrhage	contraindication	8573003
Fibrosis of lung	contraindication	51615001	DOID:3770
Metabolic acidosis	contraindication	59455009
Acute infectious disease	contraindication	63171007
Interstitial pneumonia	contraindication	64667001
Leukopenia	contraindication	84828003	DOID:615
Hypoalbuminemia	contraindication	119247004
Impaired renal function disorder	contraindication	197663003
Drug-induced hepatitis	contraindication	235876009
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Neutropenic disorder	contraindication	303011007	DOID:1227
Bone marrow depression	contraindication	307762000
Breastfeeding (mother)	contraindication	413712001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.96	acidic
pKa2	13.08	acidic
pKa3	13.86	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
DNA topoisomerase 2-alpha	Enzyme	P11388	TOP2A_HUMAN	INHIBITOR	IC50	7.30		IUPHAR	CHEMBL
Nuclear receptor subfamily 1 group I member 2	Nuclear hormone receptor	O75469	NR1I2_HUMAN					WOMBAT-PK
Canalicular multispecific organic anion transporter 2	Transporter	O15438	MRP3_HUMAN					WOMBAT-PK
Multidrug resistance-associated protein 6	Transporter	O95255	MRP6_HUMAN					WOMBAT-PK
ATP-binding cassette sub-family G member 2	Transporter	Q9UNQ0	ABCG2_HUMAN					WOMBAT-PK
Multidrug resistance-associated protein 1	Transporter	P33527	MRP1_HUMAN					WOMBAT-PK
Canalicular multispecific organic anion transporter 1	Transporter	Q92887	MRP2_HUMAN		Km	3.21		WOMBAT-PK
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		Ki	3.28		WOMBAT-PK
Arachidonate 15-lipoxygenase	Enzyme		LOX15_RABIT		IC50	5.50		DRUG MATRIX

External reference:

ID	Source
4018141	VUID
N0000146478	NUI
D00125	KEGG_DRUG
4018141	VANDF
C0015133	UMLSCUI
CHEBI:4911	CHEBI
EVP	PDB_CHEM_ID
CHEMBL44657	ChEMBL_ID
DB00773	DRUGBANK_ID
CHEMBL1200645	ChEMBL_ID
D005047	MESH_DESCRIPTOR_UI
36462	PUBCHEM_CID
6815	IUPHAR_LIGAND_ID
3835	INN_ID
6PLQ3CP4P3	UNII
220347	RXNORM
4209	MMSL
4709	MMSL
6665	MMSL
d00230	MMSL
002674	NDDF
387316009	SNOMEDCT_US
56928005	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Etoposide	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9376	INJECTION	20 mg	INTRAVENOUS	ANDA	22 sections
Etoposide	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9510	INJECTION	20 mg	INTRAVENOUS	ANDA	22 sections
Etoposide	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9511	INJECTION	20 mg	INTRAVENOUS	ANDA	22 sections
Etoposide	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9512	INJECTION	20 mg	INTRAVENOUS	ANDA	22 sections
Etoposide	HUMAN PRESCRIPTION DRUG LABEL	1	0378-3266	CAPSULE	50 mg	ORAL	ANDA	24 sections
Toposar	HUMAN PRESCRIPTION DRUG LABEL	1	0703-5653	INJECTION, SOLUTION, CONCENTRATE	20 mg	INTRAVENOUS	ANDA	24 sections
Toposar	HUMAN PRESCRIPTION DRUG LABEL	1	0703-5656	INJECTION, SOLUTION, CONCENTRATE	20 mg	INTRAVENOUS	ANDA	24 sections
Toposar	HUMAN PRESCRIPTION DRUG LABEL	1	0703-5657	INJECTION, SOLUTION, CONCENTRATE	20 mg	INTRAVENOUS	ANDA	24 sections
Etoposide	HUMAN PRESCRIPTION DRUG LABEL	1	16729-114	INJECTION	20 mg	INTRAVENOUS	ANDA	22 sections
Etoposide	HUMAN PRESCRIPTION DRUG LABEL	1	16729-262	INJECTION	20 mg	INTRAVENOUS	ANDA	22 sections
Etoposide	HUMAN PRESCRIPTION DRUG LABEL	1	63323-104	INJECTION, SOLUTION	20 mg	INTRAVENOUS	ANDA	14 sections
Etoposide	HUMAN PRESCRIPTION DRUG LABEL	1	68001-265	INJECTION	20 mg	INTRAVENOUS	ANDA	22 sections