etofylline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
N-methylated xanthine derivatives	1107	519-37-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

aethophyllinum
ascorphylline
cordalin
dilaphyllin
etophyllin
etophylline
hydroxyethyltheophylline
oxphylline
oxyethophylline
oxyethyltheophylline
oxyphyllin
oxyphylline
oxytheonyl
etofylline

etophyllin appeared once in PubMed: Wien Med Wochenschr. 1986 May 15;136(9):213-8 as a combination drug with theophylline (spelt without e, theophllin)

Molecular weight: 224.22
Formula: C9H12N4O3
CLOGP: -0.87
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 78.67
ALOGS: -1.10
ROTB: 2

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	80 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D019141	Respiratory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.55	acidic
pKa2	1.64	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Adenosine receptor A2b	GPCR	P29275	AA2BR_HUMAN		Ki	4.76		CHEMBL

External reference:

ID	Source
D07933	KEGG_DRUG
C0059871	UMLSCUI
CHEBI:94764	CHEBI
CHEMBL699	ChEMBL_ID
1892	PUBCHEM_CID
C008749	MESH_SUPPLEMENTAL_RECORD_UI
1667	INN_ID
L164909TBI	UNII
24611	RXNORM
005937	NDDF
712689006	SNOMEDCT_US

Pharmaceutical products:

None