etidocaine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
local anaesthetics	1097	36637-18-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

etidocaine
etidocaine hydrochloride
etidocaine HCl

A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.

Molecular weight: 276.42
Formula: C17H28N2O
CLOGP: 3.32
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 32.34
ALOGS: -3.16
ROTB: 7

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	24.13 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	0 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Aug. 30, 1976	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N01BB07	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, LOCAL Amides
ATC	N01BB57	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, LOCAL Amides
CHEBI has role	CHEBI:36333	local anesthetics
MeSH PA	D000777	Anesthetics
MeSH PA	D000779	Anesthetics, Local
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Sinus tachycardia	contraindication	11092001
Myocardial infarction	contraindication	22298006	DOID:5844
Parkinsonism	contraindication	32798002
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Conduction disorder of the heart	contraindication	44808001
Cerebral arteriosclerosis	contraindication	65312002
Diabetes mellitus	contraindication	73211009	DOID:9351
Cardiogenic shock	contraindication	89138009
Bleeding	contraindication	131148009
Angina pectoris	contraindication	194828000
Primary dilated cardiomyopathy	contraindication	195021004
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Disorder of coronary artery	contraindication	414024009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.24	acidic
pKa2	7.84	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium channel protein type 5 subunit alpha	Ion channel	Q14524	SCN5A_HUMAN	BLOCKER				WOMBAT-PK	CHEMBL
Sodium channel protein type 2 subunit alpha	Ion channel	Q99250	SCN2A_HUMAN	BLOCKER				UNKNOWN	CHEMBL
Sodium channel protein type 4 subunit alpha	Ion channel	P35499	SCN4A_HUMAN	BLOCKER				WOMBAT-PK	CHEMBL
Potassium channel subfamily K member 3	Ion channel	O14649	KCNK3_HUMAN		IC50	4.41		CHEMBL
Sodium channel protein type 2 subunit alpha	Ion channel		SCN2A_RAT	BLOCKER	IC50	6		IUPHAR

External reference:

ID	Source
4019752	VUID
N0000147843	NUI
D04095	KEGG_DRUG
36637-19-1	SECONDARY_CAS_RN
4018912	VANDF
4019752	VANDF
C0015120	UMLSCUI
CHEBI:4904	CHEBI
CHEMBL492	ChEMBL_ID
DB08987	DRUGBANK_ID
D005041	MESH_DESCRIPTOR_UI
37497	PUBCHEM_CID
2621	IUPHAR_LIGAND_ID
3419	INN_ID
I6CQM0F31V	UNII
227221	RXNORM
4705	MMSL
d01400	MMSL
001339	NDDF
005119	NDDF
370282009	SNOMEDCT_US
4043008	SNOMEDCT_US
88485001	SNOMEDCT_US
CHEMBL1200597	ChEMBL_ID

Pharmaceutical products:

None