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alcuronium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| neuromuscular blocking agents with rigid structure | 109 | 23214-96-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A non-depolarizing skeletal muscle relaxant similar to TUBOCURARINE. It is used as an anesthesia adjuvant, for endotracheal intubation and to produce muscle relaxation in general anesthesia during surgical procedures.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.37 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.32 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 3.60 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1963 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | M03AA01 | MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS Curare alkaloids |
| MeSH PA | D000759 | Adjuvants, Anesthesia |
| MeSH PA | D003473 | Neuromuscular Nondepolarizing Agents |
| MeSH PA | D009465 | Neuromuscular Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D018680 | Cholinergic Antagonists |
| MeSH PA | D018733 | Nicotinic Antagonists |
| CHEBI has role | CHEBI:51371 | muscle relaxant |
Related Drugs by ATC class:
M03AA Curare alkaloids 2 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.87 | acidic |
| pKa2 | 8.61 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | GPCR | ALLOSTERIC MODULATOR | Kd | 5 | IUPHAR | ||||
| Muscarinic acetylcholine receptor M2 | GPCR | ALLOSTERIC MODULATOR | Kd | 6.90 | IUPHAR | ||||
| Muscarinic acetylcholine receptor M3 | GPCR | ALLOSTERIC MODULATOR | Kd | 5.80 | IUPHAR | ||||
| Muscarinic acetylcholine receptor M4 | GPCR | Ki | 5.60 | WOMBAT-PK | |||||
| Neuronal acetylcholine receptor subunit alpha-2 | Ion channel | Ki | 4.72 | WOMBAT-PK | |||||
| Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | Ki | 5.96 | WOMBAT-PK | |||||
| Acetylcholine receptor | Ion channel | WOMBAT-PK | |||||||
| Neuronal acetylcholine receptor; alpha4/beta4 | Ion channel | IC50 | 4.35 | WOMBAT-PK | |||||
| Muscarinic acetylcholine receptor M2 | GPCR | EC50 | 8.70 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000166958 | NUI |
| D01215 | KEGG_DRUG |
| 460 | RXNORM |
| C0001981 | UMLSCUI |
| CHEMBL3305985 | ChEMBL_ID |
| CHEMBL3188339 | ChEMBL_ID |
| D000443 | MESH_DESCRIPTOR_UI |
| DB13648 | DRUGBANK_ID |
| 341 | IUPHAR_LIGAND_ID |
| 15180-03-7 | SECONDARY_CAS_RN |
| S8U3J5W06N | UNII |
| 21158560 | PUBCHEM_CID |
| CHEBI:55313 | CHEBI |
| 2166 | INN_ID |
| 003922 | NDDF |
| 004815 | NDDF |
| 350063006 | SNOMEDCT_US |
| 395958004 | SNOMEDCT_US |
| S8U3J5W06N | INXIGHT DRUGS |
Pharmaceutical products:
None