Stem definition | Drug id | CAS RN |
---|---|---|
antiepileptics, hydantoin derivatives | 1088 | 86-35-1 |
Dose | Unit | Route |
---|---|---|
2.50 | g | O |
None
Date | Agency | Company | Orphan |
---|---|---|---|
April 22, 1957 | FDA | RECORDATI RARE |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | N03AB01 | NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Hydantoin derivatives |
FDA PE | N0000008486 | Decreased Central Nervous System Disorganized Electrical Activity |
CHEBI has role | CHEBI:35623 | anticonvulsants |
MeSH PA | D000927 | Anticonvulsants |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D026941 | Sodium Channel Blockers |
MeSH PA | D061567 | Voltage-Gated Sodium Channel Blockers |
FDA EPC | N0000175753 | Anti-epileptic Agent |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Tonic-clonic epilepsy | indication | 352818000 | DOID:7725 |
Epilepsy characterized by intractable complex partial seizures | indication | 442481002 | |
Suicidal thoughts | contraindication | 6471006 | |
Mood swings | contraindication | 18963009 | |
Lymphadenopathy | contraindication | 30746006 | |
Depressive disorder | contraindication | 35489007 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Megaloblastic anemia due to folate deficiency | contraindication | 85649008 | DOID:14026 |
Disease of blood AND/OR blood-forming organ | contraindication | 191124002 | DOID:74 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pregnancy, function | contraindication | 289908002 | |
Porphyria | contraindication | 418470004 | |
Fever greater than 100.4 Fahrenheit | contraindication | 426000000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.69 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium channel alpha subunit | Ion channel | BLOCKER | CHEMBL | CHEMBL |
ID | Source |
---|---|
4018735 | VUID |
N0000147040 | NUI |
D00708 | KEGG_DRUG |
4018735 | VANDF |
C0015046 | UMLSCUI |
CHEBI:4888 | CHEBI |
CHEMBL1095 | ChEMBL_ID |
DB00754 | DRUGBANK_ID |
3292 | PUBCHEM_CID |
C084606 | MESH_SUPPLEMENTAL_RECORD_UI |
7183 | IUPHAR_LIGAND_ID |
660 | INN_ID |
46QG38NC4U | UNII |
204319 | RXNORM |
2970 | MMSL |
4702 | MMSL |
d00942 | MMSL |
001620 | NDDF |
371384002 | SNOMEDCT_US |
64463006 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Peganone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55292-601 | TABLET | 250 mg | ORAL | NDA | 12 sections |
Peganone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55292-602 | TABLET | 250 mg | ORAL | NDA | 12 sections |