ethisterone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids, progestogens | 1084 | 434-03-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
17 alpha-Hydroxypregn-4-en-20-yn-3-one. A synthetic steroid hormone with progestational effects.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 5 | mg | O |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G03DC04 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS Estren derivatives |
| ATC | G03FA03 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS AND ESTROGENS IN COMBINATION Progestogens and estrogens, fixed combinations |
| CHEBI has role | CHEBI:49103 | drug metabolites |
| CHEBI has role | CHEBI:59826 | progestins |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | Ki | 7.02 | DRUG MATRIX | |||||
| Sex hormone-binding globulin | Secreted | Kd | 8.78 | CHEMBL | |||||
| Androgen receptor | Transcription factor | Ki | 7.36 | DRUG MATRIX | |||||
| Progesterone receptor | Transcription factor | Ki | 8.11 | DRUG MATRIX | |||||
| Polyphenol oxidase 2 | Enzyme | IC50 | 5.58 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167418 | NUI |
| C0015025 | UMLSCUI |
| CHEBI:34749 | CHEBI |
| CHEMBL241694 | ChEMBL_ID |
| D005003 | MESH_DESCRIPTOR_UI |
| 5284557 | PUBCHEM_CID |
| 374 | INN_ID |
| P201BVY1MJ | UNII |
| 4129 | RXNORM |
| 001302 | NDDF |
| 126094004 | SNOMEDCT_US |
| 28841002 | SNOMEDCT_US |
Pharmaceutical products:
None