estramustine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antineoplastic, alkylating agents, (beta-chloroethyl)amine derivatives	1065	2998-57-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: estramustine estracty	A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties. Molecular weight: 440.41 Formula: C23H31Cl2NO3 CLOGP: 4.92 LIPINSKI: 0 HAC: 4 HDO: 1 TPSA: 49.77 ALOGS: -6.06 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

estramustine
estracty

A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.

Molecular weight: 440.41
Formula: C23H31Cl2NO3
CLOGP: 4.92
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 49.77
ALOGS: -6.06
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

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Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Bocci G, Oprea TI, Benet LZ
S (Water solubility)	0.00 mg/mL	Bocci G, Oprea TI, Benet LZ

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Approvals:

None

FDA Adverse Event Reporting System (Female)

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Osteonecrosis of jaw	40.66	38.12	10	119	17879	34938923

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FDA Adverse Event Reporting System (Geriatric)

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FDA Adverse Event Reporting System (Pediatric)

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Pharmacologic Action:

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Source	Code	Description
ATC	L01XX11	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Other antineoplastic agents
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:66987	radiation protective drugs
FDA CS	M0007772	Estradiol
FDA CS	M0014901	Nitrogen Mustard Compounds
FDA EPC	N0000175558	Alkylating Drug
FDA MoA	N0000000236	Alkylating Activity
MeSH PA	D000477	Alkylating Agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D018906	Antineoplastic Agents, Alkylating

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Neoplasm of prostate	indication	126906006	DOID:10283
Gynecomastia	contraindication	4754008	DOID:12698
Hypocalcemia	contraindication	5291005
Hyperbilirubinemia	contraindication	14783006	DOID:2741
Myocardial infarction	contraindication	22298006	DOID:5844
Migraine	contraindication	37796009	DOID:6364
Immunosuppression	contraindication	38013005
Hypertensive disorder	contraindication	38341003	DOID:10763
Body fluid retention	contraindication	43498006
Chronic heart failure	contraindication	48447003

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

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Acid dissociation constants calculated using MoKa v3.0.0

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Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

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Bioactivity Summary:

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External reference:

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ID	Source
004824	NDDF
108768000	SNOMEDCT_US
259331	PUBCHEM_CID
2877	INN_ID
35LT29625A	UNII
386909008	SNOMEDCT_US
4022118	VUID
4022118	VANDF
4089	RXNORM
9076	IUPHAR_LIGAND_ID

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Pharmaceutical products:

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