salbutamol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 105 18559-94-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • salbutamol
  • albuterol
  • sabumol
  • dl-Albuterol
  • dl-Salbutamol
  • albuterol sulfate
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
  • Molecular weight: 239.32
  • Formula: C13H21NO3
  • CLOGP: 0.06
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 72.72
  • ALOGS: -2.05
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.80 mg Inhal.aerosol
0.80 mg Inhal.powder
10 mg Inhal.solution
12 mg O
12 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.23 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.92 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
May 1, 1981 FDA SCHERING

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 5014.11 10.03 4454 342727 84883 50173060
Wheezing 2989.78 10.03 2843 344338 59204 50198739
Dyspnoea 2062.93 10.03 8296 338885 539312 49718631
Obstructive airways disorder 1572.80 10.03 1102 346079 14550 50243393
Product quality issue 1411.31 10.03 1375 345806 29483 50228460
Poor quality device used 1353.26 10.03 501 346680 1350 50256593
Cough 1215.85 10.03 4026 343155 237238 50020705
Sleep disorder due to a general medical condition 1053.29 10.03 647 346534 6724 50251219
Full blood count abnormal 1007.74 10.03 1009 346172 22379 50235564
Productive cough 945.46 10.03 1463 345718 51231 50206712
Chronic obstructive pulmonary disease 887.43 10.03 1432 345749 52003 50205940
Forced expiratory volume decreased 834.92 10.03 464 346717 3930 50254013
Infective pulmonary exacerbation of cystic fibrosis 696.26 10.03 514 346667 7395 50250548
Sputum discoloured 690.56 10.03 638 346543 12757 50245186
Chest discomfort 681.34 10.03 1772 345409 90950 50166993
Completed suicide 661.85 10.03 68 347113 131821 50126122
Synovitis 626.38 10.03 62 347119 123803 50134140
Systemic lupus erythematosus 604.07 10.03 116 347065 140506 50117437
Hand deformity 600.89 10.03 19 347162 100180 50157763
Pneumonia 543.78 10.03 4440 342741 373961 49883982
Device delivery system issue 543.17 10.03 180 347001 301 50257642
Glossodynia 541.75 10.03 75 347106 115494 50142449
Treatment failure 539.89 10.03 139 347042 137498 50120445
Drug intolerance 537.93 10.03 429 346752 218675 50039268
Drug ineffective 484.03 10.03 3470 343711 815863 49442080
Arthropathy 478.13 10.03 243 346938 157663 50100280
Alopecia 460.55 10.03 604 346577 244443 50013500
Bronchitis 455.88 10.03 1661 345520 102498 50155445
Anti-cyclic citrullinated peptide antibody positive 428.22 10.03 12 347169 70575 50187368
Therapeutic product effect incomplete 422.31 10.03 1485 345696 90030 50167913
Contraindicated product administered 422.21 10.03 249 346932 148709 50109234
Off label use 406.76 10.03 1775 345406 472651 49785292
Pericarditis 385.90 10.03 44 347137 78645 50179298
Product dose omission issue 322.05 10.03 2262 344919 181576 50076367
Wound 316.84 10.03 165 347016 105629 50152314
Respiratory disorder 304.50 10.03 666 346515 30521 50227422
Infusion related reaction 295.27 10.03 441 346740 169116 50088827
Abdominal discomfort 292.37 10.03 730 346451 230911 50027032
Toxicity to various agents 284.58 10.03 649 346532 211850 50046093
Therapeutic product effect decreased 283.35 10.03 309 346872 135741 50122202
No adverse event 262.18 10.03 657 346524 32921 50225022
Hepatic enzyme increased 260.48 10.03 336 346845 137044 50120899
Middle insomnia 257.54 10.03 329 346852 9592 50248351
Nasal congestion 252.66 10.03 849 346332 50271 50207672
Dyspnoea exertional 248.04 10.03 845 346336 50388 50207555
Duodenal ulcer perforation 246.53 10.03 17 347164 45594 50212349
Neutropenia 245.02 10.03 398 346783 147567 50110376
Eosinophil count increased 243.82 10.03 302 346879 8528 50249415
Helicobacter infection 243.14 10.03 28 347153 49674 50208269
Maternal exposure during pregnancy 239.93 10.03 457 346724 159321 50098622
Lower respiratory tract infection 238.31 10.03 1285 345896 93916 50164027
Rheumatoid arthritis 227.23 10.03 676 346505 201874 50056069
Pulmonary function test decreased 224.11 10.03 186 346995 3202 50254741
Nasal polyps 220.32 10.03 164 347017 2390 50255553
Upper respiratory tract infection 219.17 10.03 965 346216 64933 50193010
Loss of personal independence in daily activities 218.15 10.03 1006 346175 69044 50188899
Drug abuse 215.15 10.03 71 347110 59775 50198168
Ear pain 213.09 10.03 546 346635 27737 50230206
Sleep apnoea syndrome 201.19 10.03 481 346700 23387 50234556
Thrombocytopenia 199.78 10.03 356 346825 127317 50130626
Blood immunoglobulin E increased 193.55 10.03 147 347034 2212 50255731
Febrile neutropenia 189.10 10.03 235 346946 97432 50160511
Bronchospasm 183.85 10.03 350 346831 14504 50243439
Discomfort 183.64 10.03 287 346894 108093 50149850
Intentional overdose 183.39 10.03 100 347081 62404 50195539
Sinusitis 180.37 10.03 1876 345305 168682 50089261
Breath sounds abnormal 178.45 10.03 243 346938 7549 50250394
Swelling 176.07 10.03 744 346437 200128 50057815
Cystic fibrosis 172.54 10.03 149 347032 2715 50255228
Joint swelling 168.29 10.03 990 346191 244296 50013647
Pancytopenia 166.03 10.03 199 346982 83831 50174112
Drug interaction 164.87 10.03 756 346425 198865 50059078
Gastrooesophageal reflux disease 160.69 10.03 985 346196 75443 50182500
Bronchiectasis 160.30 10.03 268 346913 10015 50247928
Malignant neoplasm progression 155.17 10.03 143 347038 67981 50189962
Urticaria 153.86 10.03 1460 345721 128101 50129842
Influenza 153.17 10.03 1096 346085 88442 50169501
Body temperature increased 150.85 10.03 516 346665 30825 50227118
Anaemia 147.30 10.03 1070 346111 251386 50006557
Rheumatoid factor positive 145.92 10.03 80 347101 49779 50208164
Dysphonia 145.16 10.03 590 346591 38302 50219641
Rales 144.92 10.03 252 346929 9726 50248217
Device malfunction 144.27 10.03 320 346861 14801 50243142
Oropharyngeal pain 143.46 10.03 970 346211 76831 50181112
Arthralgia 142.03 10.03 2137 345044 436565 49821378
Impaired healing 140.29 10.03 163 347018 69623 50188320
Food allergy 138.95 10.03 221 346960 7916 50250027
Musculoskeletal stiffness 138.83 10.03 436 346745 128045 50129898
Sedation complication 138.71 10.03 230 346951 8536 50249407
Heart rate increased 137.02 10.03 954 346227 76296 50181647
Respiratory tract congestion 134.92 10.03 300 346881 13899 50244044
Chest pain 134.17 10.03 1826 345355 175056 50082887
Secretion discharge 132.83 10.03 240 346941 9551 50248392
Reversible airways obstruction 131.77 10.03 84 347097 936 50257007
Respiratory tract infection 131.04 10.03 500 346681 31517 50226426
Emphysema 129.92 10.03 228 346953 8865 50249078
Rhinitis allergic 129.12 10.03 200 346981 7000 50250943
Folliculitis 128.44 10.03 54 347127 39171 50218772
Peak expiratory flow rate decreased 128.12 10.03 68 347113 520 50257423
Leukopenia 126.01 10.03 167 347014 67361 50190582
Muscle injury 123.28 10.03 50 347131 37061 50220882
Eosinophilic bronchitis 122.92 10.03 62 347119 421 50257522
Oxygen saturation decreased 122.59 10.03 892 346289 72356 50185587
Anxiety 120.91 10.03 1799 345382 175807 50082136
Sensitivity to weather change 120.88 10.03 176 347005 5825 50252118
Eosinophilic granulomatosis with polyangiitis 120.39 10.03 103 347078 1852 50256091
Forced vital capacity decreased 120.33 10.03 77 347104 864 50257079
Asthmatic crisis 119.55 10.03 95 347086 1533 50256410
Sleep disorder due to general medical condition, insomnia type 118.97 10.03 34 347147 31413 50226530
Stomatitis 115.86 10.03 335 346846 101009 50156934
Lung hyperinflation 112.91 10.03 79 347102 1039 50256904
Upper-airway cough syndrome 112.72 10.03 207 346974 8343 50249600
Product container issue 112.58 10.03 87 347094 1345 50256598
General physical health deterioration 112.49 10.03 548 346633 141886 50116057
Eosinophil count abnormal 111.22 10.03 57 347124 402 50257541
Headache 108.30 10.03 4373 342808 502162 49755781
Platelet count decreased 107.95 10.03 343 346838 100383 50157560
Muscle spasticity 105.73 10.03 308 346873 16876 50241067
Respiration abnormal 104.76 10.03 151 347030 4951 50252992
White blood cell count decreased 104.23 10.03 429 346752 116293 50141650
Malaise 103.73 10.03 3024 344157 332508 49925435
Haemoptysis 103.53 10.03 398 346783 25175 50232768
Circumstance or information capable of leading to medication error 101.09 10.03 117 347064 3071 50254872
Creatinine renal clearance decreased 100.72 10.03 240 346941 11641 50246302
Temperature regulation disorder 100.11 10.03 134 347047 4093 50253850
Seasonal allergy 100.04 10.03 273 346908 14403 50243540
Rheumatic fever 98.28 10.03 4 347177 16863 50241080
Hepatic function abnormal 97.74 10.03 51 347130 32630 50225313
Respiratory rate increased 97.62 10.03 231 346950 11154 50246789
Sputum increased 94.41 10.03 88 347093 1779 50256164
Blood test abnormal 94.18 10.03 227 346954 11092 50246851
Hepatocellular injury 92.86 10.03 31 347150 25916 50232027
Bronchopulmonary aspergillosis allergic 92.86 10.03 72 347109 1119 50256824
Respiratory distress 92.75 10.03 435 346746 30054 50227889
Sinus disorder 92.43 10.03 308 346873 18150 50239793
Hypoventilation 92.40 10.03 124 347057 3797 50254146
Sopor 90.53 10.03 14 347167 19865 50238078
Product delivery mechanism issue 90.37 10.03 44 347137 274 50257669
Bronchospasm paradoxical 90.22 10.03 30 347151 51 50257892
Night sweats 89.28 10.03 461 346720 33113 50224830
Status asthmaticus 89.16 10.03 61 347120 772 50257171
Respiratory symptom 87.52 10.03 95 347086 2319 50255624
Hip arthroplasty 87.34 10.03 50 347131 30379 50227564
C-reactive protein increased 87.23 10.03 205 346976 66269 50191674
Lip swelling 86.60 10.03 368 346813 24368 50233575
Bronchial obstruction 85.70 10.03 71 347110 1219 50256724
Hepatotoxicity 83.65 10.03 41 347140 27185 50230758
Sputum purulent 83.43 10.03 62 347119 901 50257042
Knee arthroplasty 81.90 10.03 75 347106 35771 50222172
Bronchial secretion retention 81.74 10.03 74 347107 1439 50256504
Coma 80.71 10.03 168 347013 56711 50201232
Bronchial wall thickening 80.06 10.03 59 347122 846 50257097
Renal impairment 79.42 10.03 260 346921 75401 50182542
Polycystic ovaries 78.49 10.03 91 347090 2393 50255550
Acute respiratory failure 78.48 10.03 398 346783 28384 50229559
Cardio-respiratory arrest 78.32 10.03 157 347024 53735 50204208
Illness 78.25 10.03 355 346826 24185 50233758
Dust allergy 76.90 10.03 48 347133 514 50257429
Liver injury 76.75 10.03 37 347144 24769 50233174
Pulmonary mass 76.44 10.03 292 346889 18413 50239530
Throat clearing 75.58 10.03 64 347117 1134 50256809
Anaphylactic reaction 75.33 10.03 631 346550 53424 50204519
Total lung capacity increased 74.89 10.03 52 347129 675 50257268
Allergy to animal 74.84 10.03 55 347126 785 50257158
Orthostatic hypotension 74.40 10.03 399 346782 29082 50228861
Bone marrow failure 74.27 10.03 49 347132 27575 50230368
Hospitalisation 72.50 10.03 749 346432 67188 50190755
Irritable bowel syndrome 72.10 10.03 153 347028 51288 50206655
Humidity intolerance 71.84 10.03 37 347144 264 50257679
Chronic sinusitis 71.41 10.03 141 347040 6004 50251939
Swollen tongue 71.25 10.03 386 346795 28244 50229699
Rhinorrhoea 70.74 10.03 600 346581 50983 50206960
Cytomegalovirus infection 70.62 10.03 18 347163 17944 50239999
Restrictive pulmonary disease 69.86 10.03 66 347115 1358 50256585
Throat tightness 69.80 10.03 306 346875 20541 50237402
Alanine aminotransferase increased 69.11 10.03 341 346840 88018 50169925
Rhinitis 68.56 10.03 166 347015 8135 50249808
Vital capacity decreased 68.52 10.03 55 347126 901 50257042
Suicide attempt 68.30 10.03 159 347022 51573 50206370
Blood calcium decreased 67.86 10.03 302 346879 20404 50237539
Blister 67.76 10.03 328 346853 85090 50172853
Product cleaning inadequate 66.66 10.03 18 347163 6 50257937
Dermatitis atopic 64.84 10.03 100 347081 3486 50254457
Eczema 64.78 10.03 318 346863 22384 50235559
Pharyngeal swelling 64.60 10.03 114 347067 4452 50253491
Metastases to liver 63.72 10.03 29 347152 20075 50237868
Mucosal inflammation 63.57 10.03 111 347070 40031 50217912
Pulmonary function test abnormal 62.86 10.03 60 347121 1251 50256692
Coeliac disease 62.66 10.03 165 347016 8520 50249423
Choking 61.88 10.03 162 347019 8336 50249607
Product use issue 61.85 10.03 691 346490 148784 50109159
Femur fracture 61.72 10.03 101 347080 37363 50220580
Death 61.41 10.03 1731 345450 323648 49934295
Drug hypersensitivity 60.85 10.03 1286 345895 249724 50008219
Myelosuppression 60.47 10.03 10 347171 13507 50244436
Aspartate aminotransferase increased 60.43 10.03 302 346879 77696 50180247
Sensitisation 60.42 10.03 64 347117 1518 50256425
Back pain 59.84 10.03 1953 345228 218077 50039866
Rhonchi 59.08 10.03 76 347105 2231 50255712
Intentional product use issue 58.92 10.03 299 346882 76619 50181324
Overdose 58.36 10.03 422 346759 99305 50158638
Drug-induced liver injury 58.21 10.03 64 347117 28031 50229912
Hypoxia 58.09 10.03 571 346610 50552 50207391
Multiple organ dysfunction syndrome 57.79 10.03 166 347015 50171 50207772
Neurotoxicity 57.51 10.03 15 347166 14725 50243218
Viral infection 57.12 10.03 377 346804 29609 50228334
Toxic epidermal necrolysis 56.75 10.03 37 347144 20955 50236988
Posterior reversible encephalopathy syndrome 56.72 10.03 16 347165 14912 50243031
Emotional distress 56.21 10.03 363 346818 28300 50229643
Rash 56.15 10.03 2442 344739 435029 49822914
Acute kidney injury 55.97 10.03 1166 346015 226892 50031051
Disease progression 55.94 10.03 406 346775 95460 50162483
Sneezing 54.75 10.03 216 346965 13828 50244115
Perfume sensitivity 54.60 10.03 40 347141 568 50257375
Asthma-chronic obstructive pulmonary disease overlap syndrome 53.74 10.03 36 347145 439 50257504
Product complaint 53.61 10.03 187 346994 11279 50246664
Palpitations 53.60 10.03 929 346252 93577 50164366
Red blood cell sedimentation rate increased 53.59 10.03 74 347107 29342 50228601
Serotonin syndrome 51.53 10.03 56 347125 24657 50233286
Drug reaction with eosinophilia and systemic symptoms 51.29 10.03 72 347109 28352 50229591
Smoke sensitivity 51.28 10.03 31 347150 312 50257631
Agranulocytosis 51.13 10.03 43 347138 21378 50236565
Cholecystitis chronic 50.79 10.03 164 347017 9505 50248438
Total lung capacity decreased 50.68 10.03 53 347128 1238 50256705
Lower respiratory tract congestion 50.46 10.03 66 347115 1970 50255973
Decreased appetite 50.26 10.03 1024 346157 199899 50058044
Altered state of consciousness 49.86 10.03 46 347135 21864 50236079
Therapy non-responder 49.70 10.03 181 347000 50841 50207102
Neoplasm progression 49.55 10.03 77 347104 29080 50228863
Nasopharyngitis 49.52 10.03 1701 345480 191226 50066717
Blood pressure systolic increased 49.48 10.03 414 346767 35035 50222908
Conjunctivitis allergic 48.70 10.03 40 347141 678 50257265
Bronchial hyperreactivity 48.16 10.03 54 347127 1368 50256575
Drug resistance 47.99 10.03 36 347145 18953 50238990
Drug tolerance decreased 47.83 10.03 4 347177 9156 50248787
Respiratory tract inflammation 47.31 10.03 35 347146 505 50257438
Gastrointestinal disorder 47.27 10.03 417 346764 94039 50163904
Prolonged expiration 46.48 10.03 39 347142 682 50257261
Increased upper airway secretion 46.43 10.03 80 347101 3064 50254879
Lung neoplasm malignant 46.41 10.03 220 346961 15264 50242679
Infective exacerbation of chronic obstructive airways disease 46.23 10.03 47 347134 1061 50256882
Cholestasis 46.18 10.03 64 347117 25337 50232606
Polyp 45.69 10.03 111 347070 5451 50252492
Lung disorder 45.48 10.03 489 346692 44310 50213633
Nasal mucosal disorder 45.33 10.03 30 347151 358 50257585
Cerebral infarction 45.00 10.03 49 347132 21555 50236388
Incorrect dose administered 44.84 10.03 519 346662 47895 50210048
Throat irritation 44.82 10.03 358 346823 29881 50228062
Pulmonary embolism 44.80 10.03 962 346219 100742 50157201
Nasal turbinate hypertrophy 44.77 10.03 37 347144 633 50257310
Fluid retention 44.72 10.03 538 346643 50111 50207832
Mite allergy 44.38 10.03 33 347148 480 50257463
Paranasal sinus discomfort 44.13 10.03 76 347105 2910 50255033
Neutrophil count decreased 43.70 10.03 165 347016 45861 50212082
Inhalation therapy 43.24 10.03 15 347166 31 50257912
Depression 43.07 10.03 1461 345720 163962 50093981
Sedation 43.00 10.03 358 346823 30252 50227691
Rheumatoid nodule 42.55 10.03 17 347164 12718 50245225
Palmar-plantar erythrodysaesthesia syndrome 42.51 10.03 45 347136 20053 50237890
Pneumocystis jirovecii pneumonia 42.21 10.03 24 347157 14639 50243304
Insomnia 42.20 10.03 1531 345650 173334 50084609
Nasal discharge discolouration 42.15 10.03 52 347129 1462 50256481
Eosinophilia 42.11 10.03 245 346936 18407 50239536
Aphonia 42.03 10.03 141 347040 8337 50249606
Nasal obstruction 41.51 10.03 43 347138 993 50256950
Bronchial disorder 41.50 10.03 45 347136 1097 50256846
Psoriatic arthropathy 41.24 10.03 174 347007 46858 50211085
Anuria 41.00 10.03 13 347168 11231 50246712
Increased bronchial secretion 40.85 10.03 52 347129 1510 50256433
Shock 40.66 10.03 49 347132 20601 50237342
Osteonecrosis of jaw 40.54 10.03 103 347078 32423 50225520
Multiple allergies 40.41 10.03 139 347042 8324 50249619
Condition aggravated 40.39 10.03 1647 345534 295411 49962532
Wrong technique in device usage process 40.37 10.03 66 347115 2420 50255523
Confusional state 40.07 10.03 970 346211 184958 50072985
Device information output issue 39.59 10.03 15 347166 44 50257899
C-reactive protein abnormal 39.56 10.03 82 347099 27727 50230216
Lung diffusion test decreased 39.38 10.03 33 347148 576 50257367
Burning sensation 39.37 10.03 481 346700 44965 50212978
Product taste abnormal 39.32 10.03 54 347127 1691 50256252
Somnolence 39.00 10.03 789 346392 154196 50103747
Septic shock 38.98 10.03 231 346950 56944 50200999
Blood lactate dehydrogenase increased 38.96 10.03 46 347135 19516 50238427
Injection site reaction 38.59 10.03 194 346987 49838 50208105
Cystic fibrosis respiratory infection suppression 38.53 10.03 24 347157 256 50257687
Metastases to bone 38.39 10.03 40 347141 17955 50239988
Cerebral haemorrhage 38.29 10.03 80 347101 26972 50230971
Circumstance or information capable of leading to device use error 38.07 10.03 18 347163 104 50257839
Forced expiratory flow decreased 38.00 10.03 14 347167 37 50257906
Ejection fraction 37.98 10.03 44 347137 1156 50256787
Balance disorder 37.91 10.03 688 346493 69902 50188041
Hereditary angioedema 37.86 10.03 102 347079 5340 50252603
Inflammation 37.72 10.03 232 346949 56680 50201263
Drug eruption 37.63 10.03 65 347116 23541 50234402
Vocal cord dysfunction 37.41 10.03 26 347155 338 50257605
Poisoning deliberate 37.36 10.03 5 347176 7907 50250036
Fatigue 37.20 10.03 4270 342911 703331 49554612
Hiatus hernia 37 10.03 234 346947 18110 50239833
Interstitial lung disease 36.70 10.03 214 346967 52962 50204981
Sinus pain 36.68 10.03 60 347121 2201 50255742
Exposure during pregnancy 36.43 10.03 597 346584 120418 50137525
Poisoning 36.28 10.03 20 347161 12409 50245534
Disseminated intravascular coagulation 35.53 10.03 39 347142 17096 50240847
Neuropathy peripheral 35.52 10.03 459 346722 96298 50161645
Hyper IgE syndrome 35.51 10.03 27 347154 407 50257536
Frustration tolerance decreased 35.19 10.03 102 347079 5572 50252371
Blood cholesterol increased 35.09 10.03 228 346953 54987 50202956
Idiopathic intracranial hypertension 34.99 10.03 60 347121 2289 50255654
Immunodeficiency 34.94 10.03 197 346984 14631 50243312
Pruritus 34.68 10.03 2323 344858 281245 49976698
Panniculitis 34.45 10.03 8 347173 8495 50249448
Cardiotoxicity 34.26 10.03 4 347177 7023 50250920
Lung opacity 34.26 10.03 54 347127 1919 50256024
Spirometry abnormal 33.79 10.03 20 347161 193 50257750
Transplant rejection 33.49 10.03 12 347169 9597 50248346
Bronchial neoplasm 33.37 10.03 26 347155 407 50257536
Foot deformity 33.34 10.03 50 347131 19160 50238783
Eye pruritus 33.24 10.03 172 347009 12362 50245581
Sputum retention 33.15 10.03 27 347154 452 50257491
Embolism venous 33.12 10.03 61 347120 2464 50255479
Myelodysplastic syndrome 33 10.03 33 347148 15099 50242844
Forced expiratory volume abnormal 32.95 10.03 14 347167 60 50257883
Respiratory failure 32.63 10.03 838 346343 90343 50167600
Progressive multifocal leukoencephalopathy 32.63 10.03 19 347162 11438 50246505
Blood parathyroid hormone decreased 32.42 10.03 5 347176 7109 50250834
Febrile bone marrow aplasia 32.29 10.03 3 347178 6308 50251635
Nausea 32.16 10.03 4296 342885 701102 49556841
Injection site pain 32.01 10.03 552 346629 110472 50147471
Paraesthesia oral 31.92 10.03 167 347014 12054 50245889
Breath alcohol test positive 31.91 10.03 8 347173 0 50257943
Lymphopenia 31.91 10.03 36 347145 15585 50242358
Blood creatinine increased 31.90 10.03 351 346830 75809 50182134
Sinus congestion 31.86 10.03 184 346997 13787 50244156
Ulcer 31.85 10.03 56 347125 20144 50237799
Sinusitis fungal 31.85 10.03 42 347139 1264 50256679
Renal failure 31.78 10.03 527 346654 106106 50151837
Device expulsion 31.67 10.03 97 347084 28725 50229218
Gamma-glutamyltransferase increased 31.63 10.03 101 347080 29522 50228421
Intentional self-injury 31.34 10.03 70 347111 23042 50234901
Diarrhoea 31.27 10.03 3548 343633 584928 49673015
Bronchial haemorrhage 31.22 10.03 27 347154 493 50257450
Epilepsy 31.18 10.03 63 347118 21504 50236439
Cognitive disorder 31.15 10.03 450 346731 43673 50214270
Bradycardia 31.10 10.03 287 346894 64139 50193804
Aspirin-exacerbated respiratory disease 31.00 10.03 34 347147 840 50257103
Device ineffective 30.98 10.03 17 347164 140 50257803
Enthesopathy 30.71 10.03 6 347175 7187 50250756
Status epilepticus 30.68 10.03 28 347153 13378 50244565
Thrombotic microangiopathy 30.60 10.03 11 347170 8780 50249163
Cardiac failure 30.45 10.03 354 346827 75686 50182257
Exposure to allergen 30.21 10.03 18 347163 176 50257767
Extrapyramidal disorder 30.15 10.03 22 347159 11748 50246195
Lung diffusion test abnormal 29.81 10.03 17 347164 152 50257791
Herpes zoster 29.74 10.03 326 346855 70460 50187483
Haemophagocytic lymphohistiocytosis 29.71 10.03 11 347170 8622 50249321
Acute myeloid leukaemia 29.43 10.03 36 347145 15038 50242905
Respiratory gas exchange disorder 29.36 10.03 22 347159 324 50257619
Drug dependence 29.32 10.03 234 346947 19525 50238418
Swelling face 29.08 10.03 515 346666 52080 50205863
Acute hepatic failure 29.00 10.03 39 347142 15638 50242305
Foreign body in reproductive tract 28.57 10.03 25 347156 464 50257479
Hypercapnia 28.52 10.03 83 347098 4544 50253399
Infusion site swelling 28.48 10.03 111 347070 7065 50250878
Salpingo-oophorectomy unilateral 28.33 10.03 26 347155 515 50257428
Distal intestinal obstruction syndrome 28.31 10.03 22 347159 343 50257600
Ascites 28.25 10.03 138 347043 35723 50222220
Prescribed underdose 28.18 10.03 41 347140 15908 50242035
Ventricular failure 28.15 10.03 22 347159 346 50257597
Pulmonary congestion 28.02 10.03 190 346991 15057 50242886
Feeling abnormal 27.92 10.03 1089 346092 124403 50133540
Broncholithiasis 27.78 10.03 16 347165 146 50257797
Rash erythematous 27.68 10.03 363 346818 34489 50223454
Impaired quality of life 27.65 10.03 98 347083 5958 50251985
Infusion site erythema 27.63 10.03 126 347055 8601 50249342
Migraine 27.56 10.03 694 346487 74586 50183357
Sinus operation 27.50 10.03 45 347136 1651 50256292
Rhinovirus infection 27.41 10.03 69 347112 3465 50254478
Hypertensive crisis 27.21 10.03 30 347151 13124 50244819
Tubulointerstitial nephritis 26.98 10.03 39 347142 15172 50242771
Rash maculo-papular 26.95 10.03 93 347088 26548 50231395
Constipation 26.87 10.03 1544 345637 184164 50073779
Exercise tolerance decreased 26.82 10.03 84 347097 4790 50253153
Hepatic failure 26.74 10.03 122 347059 32161 50225782
Respiratory tract irritation 26.73 10.03 23 347158 417 50257526
Rubber sensitivity 26.68 10.03 46 347135 1763 50256180
Stress cardiomyopathy 26.57 10.03 116 347065 7771 50250172
Rebound nasal congestion 26.14 10.03 9 347172 18 50257925
Device deposit issue 25.94 10.03 8 347173 9 50257934
Nicotine dependence 25.91 10.03 27 347154 628 50257315
Encephalopathy 25.83 10.03 131 347050 33580 50224363
Drug level increased 25.60 10.03 59 347122 19209 50238734
Nasal oedema 25.55 10.03 30 347151 800 50257143
Skin candida 25.42 10.03 38 347143 1288 50256655
Hypothyroidism 25.28 10.03 351 346830 33774 50224169
Musculoskeletal pain 25.18 10.03 346 346835 71831 50186112
Haemoglobin decreased 25.16 10.03 672 346509 126544 50131399
Sinus tachycardia 24.98 10.03 240 346941 21114 50236829
Haemorrhage intracranial 24.75 10.03 29 347152 12345 50245598
Device defective 24.67 10.03 37 347144 1258 50256685
Generalised tonic-clonic seizure 24.54 10.03 95 347086 26215 50231728
Lymph node calcification 24.46 10.03 17 347164 221 50257722
Multiple drug therapy 24.41 10.03 46 347135 1891 50256052
Infection 24.31 10.03 955 346226 171999 50085944
Intentional device misuse 24.30 10.03 27 347154 677 50257266
Seizure 24.28 10.03 619 346562 117255 50140688
Chronic respiratory failure 24.17 10.03 42 347139 1620 50256323
Cardiac arrest 24.08 10.03 416 346765 83235 50174708
Hypercalcaemia 23.97 10.03 81 347100 23271 50234672
Injury 23.91 10.03 470 346711 48455 50209488
Nasal inflammation 23.81 10.03 21 347160 394 50257549
Polyneuropathy 23.66 10.03 29 347152 12102 50245841
Fracture 23.64 10.03 50 347131 16783 50241160
Ejection fraction decreased 23.58 10.03 58 347123 18462 50239481
Proteinuria 23.56 10.03 49 347132 16548 50241395
Blood pressure increased 23.51 10.03 1128 346053 132004 50125939
Cardiac disorder 23.46 10.03 420 346761 42559 50215384
Bronchitis bacterial 23.41 10.03 27 347154 706 50257237
Vocal cord disorder 23.40 10.03 36 347145 1252 50256691
Tuberculosis 23.14 10.03 21 347160 10062 50247881
Pyrexia 23.14 10.03 2270 344911 377933 49880010
Uveitis 23.08 10.03 18 347163 9292 50248651
Live birth 22.82 10.03 49 347132 16359 50241584
Expired product administered 22.80 10.03 85 347096 5297 50252646
Graft versus host disease 22.71 10.03 7 347174 6159 50251784
Ischaemic stroke 22.70 10.03 47 347134 15901 50242042
Rectal prolapse 22.62 10.03 42 347139 1707 50256236
Painful respiration 22.36 10.03 50 347131 2325 50255618
Unintentional medical device removal 22.24 10.03 5 347176 5430 50252513
Asthma exercise induced 22.21 10.03 17 347164 259 50257684
Tracheomalacia 21.92 10.03 13 347168 126 50257817
Gallbladder injury 21.89 10.03 35 347146 1259 50256684
Anosmia 21.86 10.03 68 347113 3863 50254080
Animal scratch 21.86 10.03 29 347152 878 50257065
Toxic skin eruption 21.83 10.03 27 347154 11224 50246719
Pharyngeal oedema 21.82 10.03 160 347021 13005 50244938
Respiratory arrest 21.66 10.03 119 347062 29890 50228053
Respiratory tract infection viral 21.61 10.03 42 347139 1767 50256176
FEV1/FVC ratio decreased 21.55 10.03 10 347171 55 50257888
Injection site erythema 21.46 10.03 373 346808 74563 50183380
Crepitations 21.36 10.03 92 347089 6127 50251816
Accidental exposure to product 21.03 10.03 84 347097 22973 50234970
Blood insulin abnormal 20.99 10.03 8 347173 24 50257919
Pulmonary pain 20.97 10.03 48 347133 2267 50255676
Metastases to central nervous system 20.93 10.03 28 347153 11254 50246689
Urosepsis 20.84 10.03 47 347134 15418 50242525
Bronchomalacia 20.83 10.03 15 347166 207 50257736
Transaminases increased 20.82 10.03 109 347072 27715 50230228
Bursitis 20.81 10.03 238 346943 21897 50236046
Dermatitis allergic 20.74 10.03 154 347027 12566 50245377
Foreign body aspiration 20.69 10.03 13 347168 141 50257802
Choking sensation 20.53 10.03 58 347123 3122 50254821
Akathisia 20.28 10.03 16 347165 8213 50249730
Peripheral sensory neuropathy 20.13 10.03 10 347171 6581 50251362
Airway remodelling 20.08 10.03 9 347172 45 50257898
Urinary tract discomfort 20.07 10.03 15 347166 220 50257723
Nasal pruritus 20.04 10.03 17 347164 302 50257641
Neutrophilia 20.03 10.03 62 347119 3513 50254430
Thunderclap headache 19.94 10.03 13 347168 151 50257792
Endometrial ablation 19.89 10.03 27 347154 836 50257107
Hypoalbuminaemia 19.84 10.03 23 347158 9837 50248106
Drug ineffective for unapproved indication 19.74 10.03 77 347104 21204 50236739
Pneumonia aspiration 19.71 10.03 128 347053 30876 50227067
Bacterial disease carrier 19.65 10.03 26 347155 785 50257158
Sputum culture positive 19.61 10.03 35 347146 1379 50256564
Pregnancy 19.37 10.03 121 347060 29456 50228487
Bradyphrenia 19.30 10.03 9 347172 6143 50251800
Nystagmus 19.28 10.03 7 347174 5554 50252389
Limb injury 19.16 10.03 218 346963 20032 50237911
Skin necrosis 19.14 10.03 28 347153 10839 50247104
Soft tissue disorder 19.12 10.03 3 347178 4211 50253732
Cervix neoplasm 19.04 10.03 14 347167 200 50257743
Tobacco abuse 18.99 10.03 22 347159 578 50257365
Aphthous ulcer 18.96 10.03 27 347154 10570 50247373
Colitis 18.87 10.03 171 347010 38358 50219585
Magnetic resonance imaging thoracic abnormal 18.87 10.03 7 347174 19 50257924
Osteomyelitis 18.80 10.03 84 347097 22269 50235674
Multiple sclerosis relapse 18.80 10.03 196 346985 42768 50215175
Grip strength decreased 18.75 10.03 34 347147 12087 50245856
Muscle rigidity 18.64 10.03 24 347157 9805 50248138
Product prescribing issue 18.60 10.03 32 347149 1224 50256719
Pre-existing condition improved 18.55 10.03 97 347084 7000 50250943
Enterocolitis 18.55 10.03 11 347170 6556 50251387
Disorientation 18.48 10.03 155 347026 35329 50222614
Mouth swelling 18.42 10.03 64 347117 3852 50254091
Cardiac murmur 18.41 10.03 132 347049 10652 50247291
Haemolytic anaemia 18.35 10.03 22 347159 9270 50248673
Rhabdomyolysis 18.34 10.03 175 347006 38852 50219091
Dehydration 18.24 10.03 857 346324 151592 50106351
Diffuse large B-cell lymphoma 18.21 10.03 8 347173 5654 50252289
Suspected suicide 18.15 10.03 7 347174 5350 50252593
Oropharyngeal discomfort 18.10 10.03 63 347118 3795 50254148
Abortion spontaneous 18.10 10.03 191 346990 41581 50216362
PCO2 increased 18.10 10.03 30 347151 1113 50256830
Nasal septum deviation 18.09 10.03 31 347150 1182 50256761
Electrocardiogram QRS complex prolonged 18.07 10.03 7 347174 5337 50252606
Brain oedema 18.00 10.03 36 347145 12334 50245609
Purpura 17.98 10.03 25 347156 9886 50248057
Separation anxiety disorder 17.89 10.03 7 347174 23 50257920
Occupational asthma 17.76 10.03 11 347170 116 50257827
Decreased bronchial secretion 17.74 10.03 9 347172 62 50257881
Oxygen consumption increased 17.70 10.03 59 347122 3477 50254466
Pulmonary toxicity 17.66 10.03 8 347173 5554 50252389
Inappropriate antidiuretic hormone secretion 17.66 10.03 40 347141 13103 50244840
Hepatitis cholestatic 17.63 10.03 10 347171 6107 50251836
Use of accessory respiratory muscles 17.46 10.03 12 347169 153 50257790
Hyperkalaemia 17.32 10.03 229 346952 47860 50210083
Ill-defined disorder 17.31 10.03 267 346914 54387 50203556
Therapy partial responder 17.30 10.03 12 347169 6579 50251364
Hepatic cytolysis 17.30 10.03 18 347163 8085 50249858
Shock haemorrhagic 17.29 10.03 19 347162 8325 50249618
Pneumonia pseudomonal 17.29 10.03 41 347140 1982 50255961
Dizziness 17.22 10.03 2667 344514 343702 49914241
Lupus-like syndrome 17.16 10.03 24 347157 9467 50248476
Venous pressure jugular increased 17.16 10.03 20 347161 529 50257414
Impaired work ability 17.15 10.03 43 347138 13597 50244346
Bronchitis chronic 17.07 10.03 62 347119 3815 50254128
Functional residual capacity increased 17.05 10.03 9 347172 68 50257875
Product use in unapproved indication 17.03 10.03 636 346545 115183 50142760
Chills 17.02 10.03 819 346362 95868 50162075
Uterine perforation 16.99 10.03 88 347093 6327 50251616
Oesophageal spasm 16.95 10.03 44 347137 2252 50255691
Rib deformity 16.95 10.03 12 347169 161 50257782
Biliary dyskinesia 16.94 10.03 47 347134 2503 50255440
Alveolar osteitis 16.92 10.03 18 347163 429 50257514
Tongue pruritus 16.89 10.03 18 347163 430 50257513
Joint stiffness 16.88 10.03 130 347051 30178 50227765
Nervousness 16.82 10.03 275 346906 27376 50230567
Gait disturbance 16.82 10.03 849 346332 149156 50108787
Red cell distribution width abnormal 16.78 10.03 11 347170 129 50257814
Angioedema 16.78 10.03 357 346824 37319 50220624
Enteritis 16.74 10.03 14 347167 6981 50250962
Stress urinary incontinence 16.74 10.03 41 347140 2024 50255919
Hyposmia 16.69 10.03 18 347163 436 50257507
Blood bilirubin increased 16.66 10.03 140 347041 31898 50226045
Cardiac failure congestive 16.64 10.03 723 346458 83659 50174284
Increased viscosity of bronchial secretion 16.58 10.03 14 347167 247 50257696
Psychotic disorder 16.57 10.03 85 347096 21727 50236216
Sinus headache 16.55 10.03 69 347112 4529 50253414
Neuroleptic malignant syndrome 16.53 10.03 32 347149 11098 50246845
Cytokine release syndrome 16.46 10.03 21 347160 8613 50249330
Sarcoidosis 16.31 10.03 73 347108 4944 50252999
Cytomegalovirus viraemia 16.21 10.03 6 347175 4703 50253240
Respiratory acidosis 16.18 10.03 83 347098 5945 50251998
Obstruction 16.15 10.03 41 347140 2070 50255873
Neurosensory hypoacusis 16.14 10.03 13 347168 214 50257729
Nephrectomy 16.11 10.03 24 347157 811 50257132
Basal cell carcinoma 16.11 10.03 94 347087 23262 50234681
Metastases to lung 16.09 10.03 32 347149 10988 50246955
Duodenal ulcer repair 16.02 10.03 8 347173 53 50257890
Depressed mood 16.00 10.03 325 346856 33698 50224245
Thyroid atrophy 15.99 10.03 6 347175 17 50257926
Pneumonectomy 15.96 10.03 4 347177 0 50257943
Joint range of motion decreased 15.91 10.03 69 347112 18443 50239500
Lip discolouration 15.91 10.03 19 347162 516 50257427
Osteonecrosis 15.86 10.03 90 347091 22427 50235516
Sputum abnormal 15.81 10.03 18 347163 464 50257479
Oxygen therapy 15.79 10.03 37 347144 1775 50256168
Bacterial tracheitis 15.74 10.03 6 347175 18 50257925
Sleep terror 15.73 10.03 22 347159 701 50257242
Pharyngitis streptococcal 15.73 10.03 109 347072 8699 50249244
Bacterial infection 15.73 10.03 176 347005 16105 50241838
Metastases to lymph nodes 15.68 10.03 15 347166 7009 50250934
Incorrect dose administered by device 15.66 10.03 56 347125 3419 50254524
Nasal mucosal discolouration 15.62 10.03 5 347176 7 50257936
Epstein-Barr virus infection 15.56 10.03 15 347166 6982 50250961
Breast cancer 15.54 10.03 204 346977 42686 50215257
Pickwickian syndrome 15.47 10.03 14 347167 272 50257671
Candida infection 15.47 10.03 237 346944 23286 50234657
Essential hypertension 15.46 10.03 66 347115 4378 50253565
Aplastic anaemia 15.46 10.03 18 347163 7685 50250258
Oral pruritus 15.43 10.03 35 347146 1643 50256300
Pathogen resistance 15.41 10.03 10 347171 5679 50252264
Macular degeneration 15.40 10.03 49 347132 14339 50243604
Infusion site urticaria 15.33 10.03 26 347155 983 50256960
Postural orthostatic tachycardia syndrome 15.32 10.03 24 347157 848 50257095
Oropharyngitis fungal 15.31 10.03 7 347174 37 50257906
Nocturnal dyspnoea 15.20 10.03 26 347155 990 50256953
Pemphigoid 15.18 10.03 11 347170 5896 50252047
Aplasia pure red cell 15.14 10.03 5 347176 4210 50253733
Adverse drug reaction 15.13 10.03 277 346904 54945 50202998
Lung operation 15.08 10.03 12 347169 194 50257749
Heart sounds 14.96 10.03 20 347161 610 50257333
Dyspnoea at rest 14.95 10.03 57 347124 3590 50254353
Erysipelas 14.89 10.03 14 347167 6594 50251349
Alanine aminotransferase abnormal 14.81 10.03 5 347176 4151 50253792
Functional residual capacity decreased 14.77 10.03 8 347173 64 50257879
Self-injurious ideation 14.73 10.03 41 347140 2188 50255755
Aplasia 14.65 10.03 4 347177 3809 50254134
Breast cancer recurrent 14.62 10.03 4 347177 3804 50254139
Eosinophilic pneumonia chronic 14.57 10.03 11 347170 164 50257779
Pneumococcal infection 14.56 10.03 16 347165 396 50257547
Immune reconstitution inflammatory syndrome 14.54 10.03 10 347171 5506 50252437
Small airways disease 14.52 10.03 5 347176 10 50257933
Hypocalcaemia 14.48 10.03 116 347065 26700 50231243
Pulmonary thrombosis 14.47 10.03 95 347086 7446 50250497
Carbon dioxide increased 14.46 10.03 27 347154 1102 50256841
Administration site erythema 14.29 10.03 18 347163 517 50257426
Intentional product misuse 14.23 10.03 230 346951 46504 50211439
Ear discomfort 14.21 10.03 87 347094 6657 50251286
Forced expiratory volume increased 14.20 10.03 5 347176 11 50257932
Cockroach allergy 14.19 10.03 7 347174 45 50257898
Factitious disorder 14.17 10.03 8 347173 70 50257873
Influenza B virus test positive 14.10 10.03 13 347168 259 50257684
PO2 decreased 14.05 10.03 30 347151 1351 50256592
Suspected COVID-19 14.03 10.03 31 347150 1430 50256513
Oxygen consumption decreased 14.02 10.03 12 347169 216 50257727
Sepsis 14.01 10.03 757 346424 132168 50125775
Bronchiolitis 14.00 10.03 42 347139 2339 50255604
Hyperprolactinaemia 13.97 10.03 3 347178 3362 50254581
Jaundice 13.96 10.03 115 347066 26314 50231629
Atopy 13.92 10.03 12 347169 218 50257725
Subdural haematoma 13.92 10.03 44 347137 12903 50245040
Skin ulcer 13.91 10.03 165 347016 35153 50222790
Bone density decreased 13.85 10.03 35 347146 11040 50246903
Carbon dioxide abnormal 13.83 10.03 10 347171 139 50257804
Bronchoscopy 13.82 10.03 7 347174 48 50257895
Blood iron decreased 13.81 10.03 131 347050 11484 50246459
Arthritis bacterial 13.81 10.03 11 347170 5618 50252325
Hyperbilirubinaemia 13.80 10.03 28 347153 9542 50248401
Central obesity 13.80 10.03 25 347156 997 50256946
Cor pulmonale 13.77 10.03 36 347145 1851 50256092
Administration site inflammation 13.74 10.03 4 347177 3 50257940
Myalgia 13.69 10.03 1010 346171 123309 50134634
Malignant mediastinal neoplasm 13.54 10.03 18 347163 546 50257397
Diastolic dysfunction 13.54 10.03 72 347109 5230 50252713
Musculoskeletal disorder 13.53 10.03 67 347114 17282 50240661
Deformity 13.46 10.03 21 347160 7919 50250024
Skin toxicity 13.44 10.03 5 347176 3908 50254035
Nasal turbinate abnormality 13.39 10.03 6 347175 30 50257913
Blood electrolytes abnormal 13.39 10.03 24 347157 949 50256994
Nightmare 13.39 10.03 169 347012 15917 50242026
Ataxia 13.36 10.03 49 347132 13737 50244206
Oral candidiasis 13.35 10.03 176 347005 16739 50241204
Deep vein thrombosis 13.34 10.03 623 346558 72681 50185262
Breast cancer stage III 13.32 10.03 3 347178 3253 50254690
Ovarian hyperstimulation syndrome 13.24 10.03 3 347178 3241 50254702
Varicella zoster gastritis 13.23 10.03 6 347175 31 50257912
Therapeutic response decreased 13.23 10.03 236 346945 46995 50210948
Hyperammonaemia 13.22 10.03 8 347173 4716 50253227
Tumour lysis syndrome 13.19 10.03 19 347162 7402 50250541
Allergic sinusitis 13.17 10.03 18 347163 561 50257382
Anhedonia 13.17 10.03 111 347070 9413 50248530
Neuromyotonia 13.14 10.03 7 347174 54 50257889
Diastolic hypotension 13.11 10.03 8 347173 82 50257861
Mucosal discolouration 13.10 10.03 16 347165 445 50257498
Radioallergosorbent test positive 13.08 10.03 6 347175 32 50257911
Kyphosis 13.04 10.03 40 347141 2255 50255688
Crystal arthropathy 13.02 10.03 12 347169 239 50257704
Mydriasis 12.97 10.03 34 347147 10593 50247350
Lactose intolerance 12.97 10.03 43 347138 2527 50255416
Nasal disorder 12.90 10.03 40 347141 2268 50255675
Nephropathy toxic 12.89 10.03 22 347159 8007 50249936
Retching 12.87 10.03 140 347041 12722 50245221
Laryngeal pain 12.83 10.03 60 347121 4139 50253804
Allergic cough 12.83 10.03 16 347165 455 50257488
Muscle spasms 12.82 10.03 1014 346167 124539 50133404
Adverse event 12.79 10.03 217 346964 43546 50214397
Exposure to SARS-CoV-2 12.74 10.03 18 347163 579 50257364
CFTR gene mutation 12.71 10.03 8 347173 87 50257856
Atypical fracture 12.70 10.03 18 347163 581 50257362
Nasal flaring 12.65 10.03 5 347176 17 50257926
Malignant melanoma 12.60 10.03 32 347149 10076 50247867
Loss of consciousness 12.60 10.03 586 346595 103767 50154176
Ileus paralytic 12.59 10.03 6 347175 4044 50253899
Peritonitis 12.54 10.03 59 347122 15427 50242516
Pulmonary hypertension 12.50 10.03 309 346872 33108 50224835
Overweight 12.46 10.03 48 347133 3038 50254905
Hyperhidrosis 12.44 10.03 741 346440 88685 50169258
Labelled drug-drug interaction medication error 12.43 10.03 34 347147 10443 50247500
Caesarean section 12.42 10.03 60 347121 15579 50242364
Liver disorder 12.42 10.03 180 347001 37042 50220901
Tremor 12.40 10.03 932 346249 113971 50143972
Liver function test increased 12.38 10.03 114 347067 25492 50232451
Lipohypertrophy 12.38 10.03 18 347163 595 50257348
Psychomotor retardation 12.38 10.03 4 347177 3414 50254529
Stevens-Johnson syndrome 12.26 10.03 93 347088 21659 50236284
Laboratory test abnormal 12.25 10.03 101 347080 23107 50234836
Kidney transplant rejection 12.25 10.03 6 347175 3981 50253962
Exostosis 12.25 10.03 40 347141 11613 50246330
Oesophagogastroduodenoscopy 12.19 10.03 8 347173 94 50257849
Demyelination 12.18 10.03 14 347167 6012 50251931
Respiratory syncytial virus bronchiolitis 12.18 10.03 13 347168 311 50257632
Injection site scab 12.08 10.03 14 347167 368 50257575
Blood pressure fluctuation 12.04 10.03 173 347008 35650 50222293
Drug delivery system issue 12.03 10.03 5 347176 20 50257923
Panic attack 12.00 10.03 193 346988 19149 50238794
Pharyngeal erythema 11.98 10.03 30 347151 1502 50256441
Noninfective bronchitis 11.97 10.03 3 347178 0 50257943
Paranoia 11.95 10.03 116 347065 10232 50247711
Delirium 11.95 10.03 187 346994 38005 50219938
Trifascicular block 11.91 10.03 8 347173 98 50257845
Oesophageal dilatation 11.89 10.03 13 347168 320 50257623
Tricuspid valve incompetence 11.86 10.03 137 347044 12633 50245310
Blood iron abnormal 11.85 10.03 4 347177 3322 50254621
Wolff-Parkinson-White syndrome 11.84 10.03 8 347173 99 50257844
Cerebellar syndrome 11.77 10.03 4 347177 3307 50254636
Cardiogenic shock 11.73 10.03 61 347120 15538 50242405
Acute sinusitis 11.72 10.03 52 347129 3508 50254435
Influenza like illness 11.70 10.03 494 346687 56965 50200978
Crying 11.67 10.03 201 346980 20215 50237728
Croup infectious 11.67 10.03 15 347166 440 50257503
Premature delivery 11.59 10.03 105 347076 23558 50234385
Pneumonia respiratory syncytial viral 11.58 10.03 18 347163 632 50257311
Pain 11.57 10.03 3674 343507 575229 49682714
Generalised anxiety disorder 11.56 10.03 33 347148 1787 50256156
Tunnel vision 11.56 10.03 19 347162 700 50257243
Lung consolidation 11.54 10.03 54 347127 3726 50254217
Poor quality product administered 11.51 10.03 44 347137 2775 50255168
Chest X-ray abnormal 11.50 10.03 55 347126 3830 50254113
Obstructive pancreatitis 11.46 10.03 11 347170 231 50257712
Sinonasal obstruction 11.45 10.03 10 347171 185 50257758
Pneumothorax spontaneous 11.45 10.03 18 347163 638 50257305
Enterovirus infection 11.44 10.03 19 347162 706 50257237
Metastasis 11.44 10.03 8 347173 4367 50253576
Product label issue 11.41 10.03 18 347163 640 50257303
Breath sounds 11.38 10.03 8 347173 106 50257837
Airway peak pressure increased 11.38 10.03 12 347169 283 50257660
Weight fluctuation 11.35 10.03 86 347095 7062 50250881
Excessive eye blinking 11.35 10.03 22 347159 924 50257019
Incorrect dose administered by product 11.34 10.03 9 347172 145 50257798
Cystic fibrosis lung 11.32 10.03 8 347173 107 50257836
Blood alkaline phosphatase increased 11.32 10.03 185 346996 37341 50220602
Jaundice cholestatic 11.31 10.03 11 347170 5100 50252843
Product expiration date issue 11.30 10.03 4 347177 9 50257934
Scleritis 11.30 10.03 4 347177 3223 50254720
Klebsiella infection 11.29 10.03 20 347161 7174 50250769
Peripheral vascular disorder 11.19 10.03 70 347111 5397 50252546
Disturbance in social behaviour 11.19 10.03 3 347178 2891 50255052
Reversible cerebral vasoconstriction syndrome 11.18 10.03 36 347145 2083 50255860
Injection site bruising 11.18 10.03 181 347000 36587 50221356
Cerebrovascular accident 11.17 10.03 533 346648 94147 50163796
Type 2 diabetes mellitus 11.16 10.03 312 346869 34063 50223880
Red blood cell count decreased 11.16 10.03 164 347017 33671 50224272
Dyspnoea paroxysmal nocturnal 11.15 10.03 20 347161 791 50257152
Hypervolaemia 11.15 10.03 241 346940 25258 50232685
Angle closure glaucoma 11.14 10.03 35 347146 1999 50255944
Gastroenteritis viral 11.12 10.03 186 346995 18600 50239343
Appetite disorder 11.12 10.03 76 347105 6038 50251905
Infusion site extravasation 11.12 10.03 84 347097 6892 50251051
Infusion site mass 11.11 10.03 25 347156 1167 50256776
BK virus infection 11.11 10.03 3 347178 2878 50255065
Blood magnesium increased 11.10 10.03 3 347178 2877 50255066
Cholecystectomy 11.10 10.03 105 347076 9198 50248745
Body temperature decreased 11.09 10.03 166 347015 16229 50241714
Haemolysis 11.09 10.03 15 347166 6001 50251942
Peak expiratory flow rate abnormal 11.06 10.03 7 347174 77 50257866
Oliguria 11.04 10.03 25 347156 8191 50249752
Eye swelling 11.04 10.03 197 346984 19947 50237996
Activated partial thromboplastin time 11.01 10.03 4 347177 10 50257933
Sweating fever 11 10.03 5 347176 26 50257917
Vertigo 10.98 10.03 271 346910 51561 50206382
Stridor 10.98 10.03 47 347134 3122 50254821
Tobacco user 10.95 10.03 19 347162 732 50257211
Hyperventilation 10.91 10.03 69 347112 5340 50252603
Adverse reaction 10.84 10.03 27 347154 8559 50249384
Tachypnoea 10.82 10.03 150 347031 14427 50243516
Mycobacterium avium complex infection 10.75 10.03 40 347141 2490 50255453
Femoral neck fracture 10.72 10.03 22 347159 7468 50250475
Increased viscosity of upper respiratory secretion 10.72 10.03 8 347173 117 50257826
Fungal pharyngitis 10.69 10.03 7 347174 82 50257861
Pneumothorax 10.66 10.03 145 347036 13889 50244054
Subarachnoid haemorrhage 10.64 10.03 38 347143 10738 50247205
Sinus polyp 10.64 10.03 12 347169 306 50257637
Eosinophilic oesophagitis 10.62 10.03 11 347170 254 50257689
COVID-19 10.62 10.03 406 346775 46256 50211687
Toothache 10.61 10.03 70 347111 16824 50241119
Product availability issue 10.59 10.03 35 347146 2053 50255890
Nasal cyst 10.58 10.03 6 347175 53 50257890
Eye paraesthesia 10.58 10.03 6 347175 53 50257890
Product administration error 10.57 10.03 192 346989 19507 50238436
Rib fracture 10.55 10.03 188 346993 19033 50238910
Ejection fraction abnormal 10.53 10.03 20 347161 827 50257116
Graft versus host disease in gastrointestinal tract 10.53 10.03 3 347178 2778 50255165
Exposure to toxic agent 10.51 10.03 6 347175 3652 50254291
Heart block congenital 10.49 10.03 4 347177 12 50257931
Tympanoplasty 10.49 10.03 4 347177 12 50257931
Forced expiratory volume 10.49 10.03 4 347177 12 50257931
Coagulopathy 10.45 10.03 76 347105 17868 50240075
Mania 10.45 10.03 39 347142 10877 50247066
Supraventricular tachycardia 10.44 10.03 134 347047 12667 50245276
Drug administered in wrong device 10.42 10.03 5 347176 30 50257913
Gallbladder disorder 10.37 10.03 167 347014 16575 50241368
Ketoacidosis 10.35 10.03 7 347174 3888 50254055
Symptom recurrence 10.33 10.03 18 347163 696 50257247
Intestinal perforation 10.32 10.03 37 347144 10442 50247501
Asthma late onset 10.29 10.03 5 347176 31 50257912
Abdominal pain upper 10.28 10.03 1246 345935 158063 50099880
Product prescribing error 10.27 10.03 93 347088 20868 50237075
Product adhesion issue 10.26 10.03 9 347172 4383 50253560
Pulmonary oedema 10.25 10.03 422 346759 48516 50209427
Hypothermia 10.20 10.03 45 347136 11971 50245972
Stress 10.18 10.03 459 346722 53334 50204609
Acute respiratory distress syndrome 10.17 10.03 94 347087 21005 50236938
Ventricular arrhythmia 10.14 10.03 5 347176 3304 50254639
PCO2 abnormal 10.13 10.03 6 347175 58 50257885
Thymus disorder 10.12 10.03 10 347171 218 50257725
Body mass index increased 10.11 10.03 22 347159 1004 50256939
Spinal pain 10.08 10.03 39 347142 10764 50247179
Blood creatine phosphokinase increased 10.07 10.03 124 347057 26243 50231700
Body temperature abnormal 10.07 10.03 25 347156 1245 50256698
Feeling jittery 10.05 10.03 119 347062 11041 50246902

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 3134.84 10.61 2158 177195 31691 29363483
Wheezing 2266.43 10.61 1762 177591 31478 29363696
Dyspnoea 1478.97 10.61 4831 174522 321901 29073273
Obstructive airways disorder 1000.68 10.61 695 178658 10321 29384853
Product quality issue 992.83 10.61 801 178552 15094 29380080
Cough 857.56 10.61 2171 177182 124556 29270618
Full blood count abnormal 834.22 10.61 707 178646 14306 29380868
Chronic obstructive pulmonary disease 811.36 10.61 1116 178237 39839 29355335
Sleep disorder due to a general medical condition 806.32 10.61 390 178963 2756 29392418
Poor quality device used 773.89 10.61 260 179093 560 29394614
Therapeutic product effect incomplete 711.68 10.61 1026 178327 38279 29356895
Infective pulmonary exacerbation of cystic fibrosis 634.19 10.61 422 178931 5814 29389360
Productive cough 604.21 10.61 842 178511 30417 29364757
Forced expiratory volume decreased 473.65 10.61 263 179090 2550 29392624
Chest discomfort 419.27 10.61 887 178466 45096 29350078
Device delivery system issue 417.26 10.61 131 179222 203 29394971
Loss of personal independence in daily activities 398.67 10.61 621 178732 24819 29370355
Sputum discoloured 393.31 10.61 323 179030 6240 29388934
Completed suicide 357.54 10.61 59 179294 90187 29304987
Toxicity to various agents 355.87 10.61 318 179035 173343 29221831
No adverse event 337.85 10.61 471 178882 17007 29378167
Pulmonary function test decreased 266.59 10.61 213 179140 3950 29391224
Bronchiectasis 263.42 10.61 258 179095 6327 29388847
Nasal congestion 253.78 10.61 430 178923 18449 29376725
Cystic fibrosis 228.21 10.61 131 179222 1361 29393813
Pneumonia 225.86 10.61 2944 176409 317228 29077946
Lower respiratory tract infection 215.02 10.61 488 178865 26014 29369160
Product dose omission issue 214.34 10.61 1151 178202 95232 29299942
Off label use 203.80 10.61 1036 178317 299764 29095410
Dyspnoea exertional 203.41 10.61 583 178770 35907 29359267
Nasal polyps 195.16 10.61 126 179227 1643 29393531
Drug abuse 193.20 10.61 123 179230 79760 29315414
Bronchitis 178.99 10.61 561 178792 36307 29358867
Drug interaction 176.09 10.61 611 178742 196774 29198400
Respiratory disorder 175.22 10.61 345 179008 16638 29378536
Febrile neutropenia 170.94 10.61 260 179093 111980 29283194
Neutropenia 165.54 10.61 344 179009 131367 29263807
Middle insomnia 159.75 10.61 185 179168 5523 29389651
Breath sounds abnormal 159.70 10.61 181 179172 5276 29389898
Sinusitis 157.90 10.61 513 178840 33837 29361337
Bronchospasm 153.85 10.61 237 179116 9372 29385802
Blood immunoglobulin E increased 149.56 10.61 111 179242 1836 29393338
Eosinophil count increased 149.00 10.61 203 179150 7166 29388008
Eosinophil count abnormal 137.80 10.61 55 179298 226 29394948
Bronchopulmonary aspergillosis allergic 132.06 10.61 64 179289 454 29394720
Influenza 128.41 10.61 549 178804 41332 29353842
Thrombocytopenia 125.78 10.61 409 178944 134414 29260760
Asthma-chronic obstructive pulmonary disease overlap syndrome 123.80 10.61 69 179284 674 29394500
Hepatic function abnormal 123.32 10.61 42 179311 39217 29355957
Anaemia 120.45 10.61 720 178633 200231 29194943
Secretion discharge 117.06 10.61 136 179217 4074 29391100
Bronchial wall thickening 116.22 10.61 75 179278 977 29394197
Pulmonary function test abnormal 113.42 10.61 97 179256 1985 29393189
Pancytopenia 113.26 10.61 207 179146 82961 29312213
Blood test abnormal 105.24 10.61 151 179202 5598 29389576
Bronchial obstruction 103.94 10.61 78 179275 1313 29393861
Reversible airways obstruction 98.86 10.61 42 179311 209 29394965
Nasopharyngitis 96.38 10.61 656 178697 59009 29336165
Bone marrow failure 94.12 10.61 25 179328 27424 29367750
Nasal obstruction 93.90 10.61 52 179301 501 29394673
Sputum increased 91.42 10.61 83 179270 1844 29393330
Bronchial disorder 91 10.61 67 179286 1094 29394080
Mucosal inflammation 90.59 10.61 39 179314 31556 29363618
Upper-airway cough syndrome 90.25 10.61 101 179252 2902 29392272
Diarrhoea 90.18 10.61 1448 177905 331250 29063924
Asthmatic crisis 89.56 10.61 46 179307 375 29394799
Emphysema 89.25 10.61 176 179177 8495 29386679
Respiratory tract congestion 89.03 10.61 133 179220 5116 29390058
Eosinophilic granulomatosis with polyangiitis 88.92 10.61 71 179282 1315 29393859
Malignant neoplasm progression 88.45 10.61 198 179155 73661 29321513
Cytomegalovirus infection 87.89 10.61 17 179336 23198 29371976
Sinus pain 87.22 10.61 51 179302 550 29394624
Vital capacity decreased 84.38 10.61 42 179311 318 29394856
Leukopenia 82.87 10.61 129 179224 55074 29340100
Bronchial secretion retention 82.50 10.61 63 179290 1090 29394084
Obstruction 81.80 10.61 78 179275 1848 29393326
Gastrooesophageal reflux disease 81.67 10.61 393 178960 31103 29364071
Lung consolidation 81.59 10.61 125 179228 4918 29390256
Platelet count decreased 81.50 10.61 342 179011 104330 29290844
Haemoptysis 80.52 10.61 383 178970 30167 29365007
Dust allergy 80.35 10.61 45 179308 444 29394730
Lung hyperinflation 80.25 10.61 54 179299 758 29394416
Malaise 80.03 10.61 1386 177967 158216 29236958
Intentional overdose 78.15 10.61 71 179282 38457 29356717
Bronchial hyperreactivity 77.60 10.61 66 179287 1340 29393834
Chronic sinusitis 74.01 10.61 70 179283 1641 29393533
Hospitalisation 73.87 10.61 505 178848 45483 29349691
Hypoxia 73.00 10.61 515 178838 46864 29348310
Rhinorrhoea 72.94 10.61 291 179062 21228 29373946
Sinus congestion 72.77 10.61 113 179240 4499 29390675
Device malfunction 72.72 10.61 160 179193 8347 29386827
Respiratory rate increased 72.43 10.61 162 179191 8546 29386628
Upper respiratory tract infection 72.17 10.61 343 179010 27006 29368168
Renal impairment 72.17 10.61 252 179101 81081 29314093
Treatment failure 71.50 10.61 71 179282 36868 29358306
Oxygen saturation decreased 71.31 10.61 492 178861 44445 29350729
White blood cell count decreased 70.19 10.61 264 179089 83098 29312076
Coma 69.51 10.61 82 179271 39368 29355806
Drug resistance 69.47 10.61 22 179331 21518 29373656
Forced vital capacity decreased 67.83 10.61 45 179308 616 29394558
Throat irritation 67.07 10.61 158 179195 8627 29386547
Product container issue 67.03 10.61 43 179310 554 29394620
Acute kidney injury 67.01 10.61 1169 178184 264098 29131076
Interstitial lung disease 66.46 10.61 158 179195 57560 29337614
Renal failure 65.73 10.61 435 178918 118164 29277010
Stress 64.52 10.61 280 179073 21210 29373964
Blood creatinine increased 63.81 10.61 282 179071 84820 29310354
Pyrexia 62.96 10.61 1299 178054 286323 29108851
Heart rate increased 62.78 10.61 428 178925 38510 29356664
Lung disorder 61.61 10.61 354 178999 30008 29365166
Bronchospasm paradoxical 59.86 10.61 20 179333 42 29395132
Septic shock 59.49 10.61 188 179165 62372 29332802
Device ineffective 59.23 10.61 17 179336 15 29395159
Seasonal allergy 59.22 10.61 109 179244 4993 29390181
Circumstance or information capable of leading to device use error 58.96 10.61 15 179338 3 29395171
Sleep terror 58.61 10.61 43 179310 698 29394476
Stomatitis 57.36 10.61 85 179268 37028 29358146
Sleep apnoea syndrome 57.26 10.61 235 179118 17364 29377810
Neuropathy peripheral 56.54 10.61 230 179123 70797 29324377
Pneumocystis jirovecii pneumonia 56.18 10.61 16 179337 16763 29378411
Neutrophil count decreased 56.15 10.61 112 179241 43455 29351719
Rhonchi 56.06 10.61 59 179294 1579 29393595
Respiratory distress 56.04 10.61 360 178993 31746 29363428
Inhalation therapy 55.81 10.61 16 179337 14 29395160
Sensitivity to weather change 55.63 10.61 55 179298 1364 29393810
Rhabdomyolysis 54.88 10.61 187 179166 60621 29334553
Lower respiratory tract congestion 53.71 10.61 47 179306 993 29394181
Disseminated intravascular coagulation 53.66 10.61 27 179326 19953 29375221
Lung diffusion test decreased 53.19 10.61 37 179316 550 29394624
Respiratory tract infection 52.52 10.61 211 179142 15440 29379734
Increased bronchial secretion 52.43 10.61 56 179297 1525 29393649
Spirometry abnormal 52.11 10.61 31 179322 346 29394828
Restrictive pulmonary disease 51.59 10.61 47 179306 1049 29394125
Cerebral infarction 50.60 10.61 45 179308 24630 29370544
Oropharyngeal pain 49.06 10.61 325 179028 28960 29366214
Right atrial hypertrophy 48.73 10.61 34 179319 508 29394666
Allergy to animal 48.45 10.61 26 179327 234 29394940
Myelosuppression 48.35 10.61 8 179345 12219 29382955
Dyspnoea at rest 48.29 10.61 77 179276 3137 29392037
Hepatotoxicity 48.20 10.61 24 179329 17843 29377331
Dermatitis atopic 47.71 10.61 63 179290 2156 29393018
Disease progression 47.63 10.61 296 179057 81620 29313554
Throat tightness 47.20 10.61 121 179232 6970 29388204
Bronchiolitis 47 10.61 70 179283 2685 29392489
Body temperature decreased 46.94 10.61 157 179196 10507 29384667
Appendicolith 46.39 10.61 79 179274 3401 29391773
Drug intolerance 46.26 10.61 145 179208 48234 29346940
Drug-induced liver injury 46.23 10.61 38 179315 21617 29373557
Cerebral haemorrhage 45.67 10.61 75 179278 31351 29363823
Rhinitis 45.61 10.61 94 179259 4684 29390490
Respiratory symptom 45.37 10.61 41 179312 905 29394269
Drug reaction with eosinophilia and systemic symptoms 45.34 10.61 62 179291 27930 29367244
Respiratory failure 44.87 10.61 833 178520 96298 29298876
Pulmonary mass 44.47 10.61 155 179198 10593 29384581
Blood lactate dehydrogenase increased 44.47 10.61 31 179322 19178 29375996
Hypoventilation 43.98 10.61 69 179284 2772 29392402
Rales 43.77 10.61 122 179231 7388 29387786
Conjunctivitis allergic 43.20 10.61 34 179319 616 29394558
Peak expiratory flow rate decreased 42.82 10.61 19 179334 107 29395067
Increased viscosity of bronchial secretion 42.16 10.61 22 179331 186 29394988
Death 42.10 10.61 1673 177680 340411 29054763
Overdose 41.59 10.61 298 179055 79521 29315653
Chest X-ray abnormal 41.47 10.61 79 179274 3715 29391459
Anaphylactic reaction 41.45 10.61 298 179055 27275 29367899
Blood cholesterol 41.32 10.61 21 179332 167 29395007
Cardiac failure 40.84 10.61 297 179056 78990 29316184
Forced expiratory flow decreased 40.34 10.61 20 179333 150 29395024
Palmar-plantar erythrodysaesthesia syndrome 38.07 10.61 21 179332 14738 29380436
Painful respiration 37.90 10.61 41 179312 1133 29394041
Crepitations 37.60 10.61 63 179290 2676 29392498
C-reactive protein increased 37.34 10.61 140 179213 44123 29351051
Multiple organ dysfunction syndrome 37.23 10.61 227 179126 62889 29332285
Acute respiratory failure 37.21 10.61 281 179072 26121 29369053
Synovitis 37.17 10.61 10 179343 10880 29384294
Circumstance or information capable of leading to medication error 37.07 10.61 46 179307 1478 29393696
Respiration abnormal 35.94 10.61 61 179292 2619 29392555
Serotonin syndrome 35.83 10.61 32 179321 17480 29377694
Sputum abnormal 35.76 10.61 26 179327 416 29394758
Product complaint 35.73 10.61 92 179261 5313 29389861
Impaired quality of life 35.64 10.61 60 179293 2559 29392615
Atelectasis 35.61 10.61 186 179167 15206 29379968
Sopor 35.56 10.61 11 179342 10923 29384251
Cystic fibrosis respiratory infection suppression 35.48 10.61 20 179333 200 29394974
Status asthmaticus 35.20 10.61 22 179331 270 29394904
Agranulocytosis 35.05 10.61 43 179310 20297 29374877
Choking 34.53 10.61 81 179272 4410 29390764
Cardio-respiratory arrest 34.20 10.61 174 179179 50427 29344747
Airway remodelling 34.01 10.61 17 179336 130 29395044
Acute myeloid leukaemia 33.99 10.61 30 179323 16483 29378691
Progressive multifocal leukoencephalopathy 33.83 10.61 6 179347 8713 29386461
Neuroleptic malignant syndrome 33.65 10.61 29 179324 16119 29379055
Thrombotic microangiopathy 33.62 10.61 6 179347 8675 29386499
Mite allergy 33.55 10.61 22 179331 295 29394879
Hyperthermia 33.46 10.61 8 179345 9422 29385752
Posterior reversible encephalopathy syndrome 33.08 10.61 7 179346 8969 29386205
Spinal muscular atrophy 33.04 10.61 21 179332 266 29394908
Smoke sensitivity 32.84 10.61 16 179337 115 29395059
Vocal cord dysfunction 32.45 10.61 17 179336 145 29395029
Altered state of consciousness 32.26 10.61 44 179309 19845 29375329
Eye pruritus 32.08 10.61 77 179276 4255 29390919
Cytopenia 31.91 10.61 10 179343 9849 29385325
Tubulointerstitial nephritis 31.80 10.61 36 179317 17607 29377567
Osteonecrosis of jaw 31.64 10.61 32 179321 16478 29378696
Blood pressure systolic increased 31.33 10.61 192 179161 16653 29378521
Sneezing 31.13 10.61 77 179276 4337 29390837
Eosinophilic bronchitis 30.95 10.61 17 179336 161 29395013
Hepatitis 30.76 10.61 49 179304 20734 29374440
Depressed level of consciousness 30.41 10.61 118 179235 36824 29358350
Breath alcohol test positive 30.36 10.61 8 179345 3 29395171
Eosinophilia 30.19 10.61 234 179119 21927 29373247
Throat clearing 29.95 10.61 18 179335 205 29394969
Increased upper airway secretion 29.94 10.61 42 179311 1524 29393650
Hormone receptor positive breast cancer 29.93 10.61 10 179343 21 29395153
Forced expiratory volume 29.90 10.61 14 179339 91 29395083
Eosinophil count 29.65 10.61 15 179338 118 29395056
Mycotic allergy 29.60 10.61 19 179334 245 29394929
Nasal disorder 29.41 10.61 40 179313 1409 29393765
Pickwickian syndrome 29.39 10.61 12 179341 53 29395121
Decreased activity 29.37 10.61 68 179285 3670 29391504
Suicide attempt 29.35 10.61 107 179246 34003 29361171
Anxiety 29.28 10.61 701 178652 84664 29310510
Blood immunoglobulin E decreased 29.24 10.61 11 179342 37 29395137
Obesity 29.21 10.61 128 179225 9735 29385439
Poisoning 29.18 10.61 12 179341 9981 29385193
Congenital hiatus hernia 29.12 10.61 23 179330 419 29394755
Product use in unapproved indication 29.08 10.61 362 178991 86513 29308661
Nasal inflammation 29.08 10.61 18 179335 217 29394957
Suffocation feeling 29.01 10.61 25 179328 517 29394657
C-reactive protein abnormal 28.90 10.61 3 179350 6533 29388641
Product delivery mechanism issue 28.83 10.61 15 179338 126 29395048
Respiratory tract irritation 28.43 10.61 15 179338 130 29395044
Wrong technique in device usage process 28.42 10.61 34 179319 1051 29394123
Hepatic failure 28.35 10.61 97 179256 31415 29363759
Rhinitis allergic 28.31 10.61 55 179298 2625 29392549
Right ventricular hypertrophy 28.17 10.61 35 179318 1126 29394048
Victim of child abuse 28.14 10.61 30 179323 815 29394359
Lymph node calcification 27.95 10.61 15 179338 135 29395039
Polyneuropathy 27.62 10.61 20 179333 12132 29383042
Haemoglobin decreased 27.44 10.61 477 178876 107898 29287276
Neoplasm progression 27.43 10.61 44 179309 18568 29376606
Graft versus host disease 27.41 10.61 12 179341 9616 29385558
Factitious disorder 27.41 10.61 11 179342 46 29395128
Chest pain 27.28 10.61 880 178473 111093 29284081
Transplant rejection 27.00 10.61 11 179342 9201 29385973
Peritonitis 26.99 10.61 30 179323 14794 29380380
Pneumonia lipoid 26.98 10.61 12 179341 68 29395106
Rheumatoid arthritis 26.92 10.61 102 179251 32050 29363124
Snoring 26.84 10.61 55 179298 2729 29392445
Haematochezia 26.83 10.61 124 179229 36859 29358315
Pathogen resistance 26.69 10.61 8 179345 8108 29387066
Pancreatitis 26.68 10.61 113 179240 34401 29360773
Viral infection 26.41 10.61 167 179186 14643 29380531
Dysphonia 26.31 10.61 203 179150 18993 29376181
Wolff-Parkinson-White syndrome 26.12 10.61 16 179337 189 29394985
Sleep disorder 26.09 10.61 244 179109 24142 29371032
Food allergy 26.07 10.61 31 179322 952 29394222
Upper respiratory fungal infection 25.90 10.61 14 179339 128 29395046
Multiple allergies 25.78 10.61 46 179307 2056 29393118
Total lung capacity decreased 25.75 10.61 24 179329 552 29394622
Nightmare 25.74 10.61 137 179216 11280 29383894
Mycobacterium avium complex infection 25.74 10.61 48 179305 2221 29392953
Encephalopathy 25.65 10.61 99 179254 30944 29364230
Skin discomfort 25.53 10.61 11 179342 57 29395117
Osteoporosis 25.51 10.61 131 179222 10638 29384536
Perfume sensitivity 25.26 10.61 12 179341 81 29395093
Hypercapnia 25.23 10.61 64 179289 3662 29391512
Rhinitis perennial 25.22 10.61 16 179337 202 29394972
Neurotoxicity 25.07 10.61 31 179322 14582 29380592
Colitis 24.97 10.61 101 179252 31147 29364027
Mean platelet volume increased 24.95 10.61 21 179332 420 29394754
Superinfection 24.81 10.61 44 179309 1957 29393217
Hypopnoea 24.52 10.61 34 179319 1220 29393954
Hyperbilirubinaemia 24.26 10.61 33 179320 14901 29380273
Haemophagocytic lymphohistiocytosis 24.25 10.61 17 179336 10487 29384687
Parathyroid gland enlargement 24.22 10.61 13 179340 117 29395057
Respiratory syncytial virus infection 23.90 10.61 62 179291 3597 29391577
Hepatocellular injury 23.77 10.61 59 179294 21184 29373990
Metabolic acidosis 23.51 10.61 133 179220 37529 29357645
Foetal malformation 23.50 10.61 13 179340 125 29395049
Confusional state 23.48 10.61 593 178760 127284 29267890
Herpes zoster 23.47 10.61 98 179255 29954 29365220
Akathisia 23.38 10.61 6 179347 6736 29388438
Liver disorder 23.25 10.61 88 179265 27661 29367513
Ear infection 23.14 10.61 104 179249 7996 29387178
Shock haemorrhagic 22.66 10.61 15 179338 9536 29385638
Respiratory tract infection bacterial 22.64 10.61 23 179330 590 29394584
Hypotension 22.22 10.61 958 178395 193396 29201778
FEV1/FVC ratio decreased 22.16 10.61 10 179343 59 29395115
Sepsis 21.77 10.61 679 178674 142003 29253171
Alanine aminotransferase increased 21.76 10.61 301 179052 70643 29324531
Eye swelling 21.69 10.61 107 179246 8550 29386624
Product administered to patient of inappropriate age 21.64 10.61 49 179304 2606 29392568
Therapy non-responder 21.62 10.61 105 179248 30806 29364368
Tracheal disorder 21.55 10.61 12 179341 117 29395057
Right atrial enlargement 21.50 10.61 15 179338 224 29394950
Therapy partial responder 21.47 10.61 3 179350 5196 29389978
Product taste abnormal 21.40 10.61 29 179324 1018 29394156
Cytokine release syndrome 21.30 10.61 29 179324 13090 29382084
Tumour lysis syndrome 21.25 10.61 32 179321 13852 29381322
Gamma-glutamyltransferase increased 21.00 10.61 87 179266 26650 29368524
Epstein-Barr virus infection 20.97 10.61 7 179346 6622 29388552
Chronic kidney disease 20.93 10.61 132 179221 36284 29358890
Proteinuria 20.90 10.61 40 179313 15764 29379410
Brain oedema 20.88 10.61 26 179327 12194 29382980
Low birth weight baby 20.86 10.61 7 179346 6601 29388573
Hepatitis B 20.86 10.61 4 179349 5493 29389681
Illness 20.83 10.61 88 179265 6586 29388588
Discomfort 20.73 10.61 157 179196 14606 29380568
Cerebral artery thrombosis 20.68 10.61 24 179329 718 29394456
Nasal oedema 20.51 10.61 16 179337 286 29394888
Hyperkalaemia 20.46 10.61 256 179097 61136 29334038
Swollen tongue 20.46 10.61 136 179217 12130 29383044
Lymphocyte count abnormal 20.42 10.61 22 179331 605 29394569
Aspartate aminotransferase increased 20.30 10.61 248 179105 59477 29335697
Hypersensitivity 20.17 10.61 441 178912 52462 29342712
Soft tissue mass 20.16 10.61 22 179331 614 29394560
Chronic respiratory failure 20.02 10.61 31 179322 1231 29393943
Foetal exposure during pregnancy 19.86 10.61 122 179231 33745 29361429
Tachypnoea 19.70 10.61 158 179195 14957 29380217
Pulmonary congestion 19.62 10.61 136 179217 12300 29382874
Cystitis haemorrhagic 19.52 10.61 3 179350 4839 29390335
Ocular discomfort 19.50 10.61 36 179317 1653 29393521
Cor pulmonale acute 19.47 10.61 14 179339 220 29394954
Fractional exhaled nitric oxide increased 19.43 10.61 17 179336 359 29394815
Disease complication 19.41 10.61 44 179309 2342 29392832
Nasal discharge discolouration 19.36 10.61 14 179339 222 29394952
Lower respiratory tract infection bacterial 19.31 10.61 16 179337 313 29394861
Trisomy 18 19.29 10.61 13 179340 183 29394991
Drug eruption 19.12 10.61 46 179307 16695 29378479
Encephalitis toxic 19.05 10.61 15 179338 272 29394902
Blood alkaline phosphatase increased 19.00 10.61 98 179255 28308 29366866
Seizure 18.98 10.61 425 178928 92698 29302476
Attention-seeking behaviour 18.96 10.61 8 179345 39 29395135
Myelodysplastic syndrome 18.70 10.61 51 179302 17743 29377431
Viral upper respiratory tract infection 18.68 10.61 45 179308 2492 29392682
Swelling face 18.56 10.61 197 179156 20153 29375021
Disorientation 18.54 10.61 104 179249 29411 29365763
Myocardial infarction 18.53 10.61 518 178835 109778 29285396
Metastases to liver 18.46 10.61 27 179326 11829 29383345
Mood swings 18.44 10.61 90 179263 7161 29388013
Total lung capacity abnormal 18.40 10.61 11 179342 124 29395050
Blood bilirubin increased 18.39 10.61 125 179228 33768 29361406
Toxic epidermal necrolysis 18.36 10.61 53 179300 18100 29377074
Accidental exposure to product 18.25 10.61 23 179330 10730 29384444
Paranasal sinus discomfort 18.24 10.61 22 179331 686 29394488
Appendicitis 18.22 10.61 103 179250 8676 29386498
Oesophageal polyp 18.18 10.61 8 179345 44 29395130
Epidural lipomatosis 18.17 10.61 22 179331 689 29394485
Pancreatitis acute 18.14 10.61 81 179272 24304 29370870
Kidney transplant rejection 18.02 10.61 10 179343 6995 29388179
Migraine 17.91 10.61 133 179220 12297 29382877
Cytomegalovirus viraemia 17.80 10.61 8 179345 6312 29388862
Cystic fibrosis related diabetes 17.74 10.61 11 179342 133 29395041
Panic reaction 17.72 10.61 30 179323 1285 29393889
Infective exacerbation of chronic obstructive airways disease 17.60 10.61 34 179319 1616 29393558
Dehydration 17.51 10.61 546 178807 114202 29280972
Oesophageal carcinoma 17.47 10.61 64 179289 4483 29390691
Pharyngeal oedema 17.43 10.61 75 179278 5659 29389515
Somnolence 17.42 10.61 435 178918 93520 29301654
Blood creatine phosphokinase increased 17.37 10.61 160 179193 40484 29354690
Social avoidant behaviour 17.35 10.61 48 179305 2894 29392280
Decreased gait velocity 17.33 10.61 11 179342 139 29395035
Squamous cell carcinoma 17.32 10.61 22 179331 10229 29384945
Rhinalgia 17.31 10.61 16 179337 364 29394810
Sensory integrative dysfunction 17.31 10.61 7 179346 30 29395144
Benign prostatic hyperplasia 17.27 10.61 126 179227 11584 29383590
Blood urine 17.25 10.61 17 179336 420 29394754
Shock 17.21 10.61 69 179284 21335 29373839
Sputum purulent 17.18 10.61 17 179336 422 29394752
Aortic valve stenosis 17.17 10.61 40 179313 2168 29393006
Accessory spleen 17.13 10.61 11 179342 142 29395032
Mucormycosis 17.12 10.61 5 179348 5153 29390021
Polyp 17.07 10.61 50 179303 3115 29392059
Animal scratch 17.05 10.61 12 179341 182 29394992
Enterococcal infection 17.04 10.61 15 179338 8253 29386921
Red cell distribution width increased 17.04 10.61 65 179288 4642 29390532
Transaminases increased 17.02 10.61 75 179278 22587 29372587
Infusion related reaction 16.97 10.61 177 179176 43709 29351465
Fall 16.93 10.61 890 178463 176288 29218886
Lip swelling 16.88 10.61 131 179222 12279 29382895
Urinary tract infection 16.87 10.61 323 179030 72031 29323143
Sinus operation 16.86 10.61 19 179334 550 29394624
Restlessness 16.81 10.61 73 179280 22072 29373102
Nasal discomfort 16.80 10.61 28 179325 1184 29393990
Urinary retention 16.64 10.61 119 179234 31779 29363395
Second primary malignancy 16.64 10.61 10 179343 6695 29388479
Rhinovirus infection 16.58 10.61 50 179303 3166 29392008
Brain scan abnormal 16.55 10.61 23 179330 827 29394347
Extrapyramidal disorder 16.54 10.61 25 179328 10806 29384368
Anger 16.54 10.61 118 179235 10772 29384402
Anosmia 16.51 10.61 37 179316 1954 29393220
Lung opacity 16.48 10.61 30 179323 1362 29393812
Acute graft versus host disease in skin 16.46 10.61 4 179349 4660 29390514
Bed bug infestation 16.45 10.61 4 179349 0 29395174
Aptyalism 16.35 10.61 14 179339 287 29394887
Gait disturbance 16.33 10.61 330 179023 73019 29322155
Device related infection 16.29 10.61 45 179308 15591 29379583
Hypoacusis 16.28 10.61 146 179207 14277 29380897
Haematuria 16.27 10.61 180 179173 43959 29351215
Nephropathy toxic 16.26 10.61 25 179328 10731 29384443
Pneumococcal sepsis 16.22 10.61 23 179330 843 29394331
Blood pressure increased 16.17 10.61 573 178780 73230 29321944
Sarcopenia 16.02 10.61 15 179338 347 29394827
Inspiratory capacity abnormal 15.97 10.61 9 179344 90 29395084
Intentional device misuse 15.96 10.61 11 179342 161 29395013
Pleural thickening 15.95 10.61 14 179339 297 29394877
Ventricular hyperkinesia 15.94 10.61 12 179341 203 29394971
Aspirin-exacerbated respiratory disease 15.88 10.61 15 179338 351 29394823
Product cleaning inadequate 15.83 10.61 5 179348 8 29395166
Acute generalised exanthematous pustulosis 15.83 10.61 7 179346 5576 29389598
Myoclonus 15.65 10.61 36 179317 13273 29381901
Anuria 15.58 10.61 21 179332 9520 29385654
Febrile bone marrow aplasia 15.56 10.61 13 179340 7338 29387836
Drug level increased 15.47 10.61 60 179293 18727 29376447
Jaundice 15.43 10.61 109 179244 29187 29365987
Ileus 15.34 10.61 41 179312 14361 29380813
General physical health deterioration 15.31 10.61 491 178862 102366 29292808
Flour sensitivity 15.16 10.61 6 179347 24 29395150
Mycobacterium test positive 15.11 10.61 15 179338 374 29394800
Cholestasis 15.10 10.61 82 179271 23380 29371794
Renal tubular necrosis 15.06 10.61 41 179312 14274 29380900
Subdural haematoma 15.04 10.61 58 179295 18135 29377039
Neurodevelopmental disorder 14.88 10.61 14 179339 326 29394848
Hepatitis cholestatic 14.83 10.61 12 179341 6881 29388293
Post-tussive vomiting 14.81 10.61 5 179348 11 29395163
Social problem 14.81 10.61 21 179332 770 29394404
Psoriatic arthropathy 14.77 10.61 43 179310 14648 29380526
Device information output issue 14.63 10.61 8 179345 75 29395099
Oliguria 14.62 10.61 14 179339 7398 29387776
Lung neoplasm malignant 14.53 10.61 142 179211 14215 29380959
Renal disorder 14.53 10.61 79 179274 22516 29372658
End stage renal disease 14.52 10.61 15 179338 7649 29387525
Musculoskeletal stiffness 14.51 10.61 151 179202 37307 29357867
Withdrawal syndrome 14.38 10.61 28 179325 10964 29384210
Substance abuse 14.37 10.61 12 179341 6775 29388399
Klebsiella infection 14.36 10.61 14 179339 7335 29387839
Haemophilus infection 14.30 10.61 23 179330 944 29394230
Cystic fibrosis lung 14.29 10.61 7 179346 51 29395123
Lung diffusion disorder 14.28 10.61 8 179345 79 29395095
Small airways disease 14.26 10.61 6 179347 29 29395145
Haemorrhage 14.26 10.61 190 179163 44882 29350292
Blood pressure fluctuation 14.25 10.61 67 179286 19827 29375347
Foreign body aspiration 14.24 10.61 10 179343 151 29395023
Intentional product use issue 14.24 10.61 177 179176 42321 29352853
Stoma closure 14.23 10.61 9 179344 113 29395061
Renal injury 14.22 10.61 25 179328 10177 29384997
Metastases to lung 14.18 10.61 16 179337 7839 29387335
Carbon dioxide increased 14.17 10.61 23 179330 951 29394223
Bradyphrenia 14.14 10.61 4 179349 4210 29390964
Influenza B virus test positive 14.03 10.61 8 179345 82 29395092
Infective exacerbation of bronchiectasis 14.03 10.61 15 179338 409 29394765
Alveolar bone resorption 13.97 10.61 5 179348 14 29395160
Aplastic anaemia 13.89 10.61 15 179338 7495 29387679
Hypercalcaemia 13.84 10.61 36 179317 12723 29382451
Sinus disorder 13.80 10.61 72 179281 5883 29389291
Atopy 13.77 10.61 9 179344 120 29395054
Dry skin 13.72 10.61 208 179145 23099 29372075
Diastolic dysfunction 13.71 10.61 64 179289 5000 29390174
Blood urea increased 13.65 10.61 107 179246 28005 29367169
Acute myocardial infarction 13.63 10.61 209 179144 48229 29346945
Lacrimal disorder 13.56 10.61 13 179340 310 29394864
Rubber sensitivity 13.52 10.61 9 179344 124 29395050
Joint injury 13.51 10.61 80 179273 6853 29388321
Bradycardia 13.51 10.61 299 179054 65330 29329844
Emotional disorder of childhood 13.49 10.61 6 179347 34 29395140
Squamous cell carcinoma of skin 13.45 10.61 23 179330 9463 29385711
Hepatic steatosis 13.45 10.61 46 179307 14900 29380274
Lymphopenia 13.33 10.61 40 179313 13493 29381681
Basal cell carcinoma 13.29 10.61 55 179298 16855 29378319
Bronchial irritation 13.25 10.61 5 179348 17 29395157
Ataxia 13.24 10.61 34 179319 12069 29383105
Incorrect dose administered by device 13.21 10.61 29 179324 1510 29393664
BK virus infection 13.19 10.61 6 179347 4701 29390473
Lung hernia 13.14 10.61 7 179346 62 29395112
Palpitations 13.13 10.61 274 179079 32330 29362844
Personal relationship issue 13.13 10.61 12 179341 269 29394905
Brain injury 13.02 10.61 67 179286 5445 29389729
Resuscitation 12.96 10.61 25 179328 1187 29393987
Parkinsonism 12.95 10.61 15 179338 7263 29387911
Lacunar stroke 12.87 10.61 9 179344 135 29395039
Encephalitis 12.85 10.61 12 179341 6418 29388756
Deep vein thrombosis 12.84 10.61 258 179095 57141 29338033
Gastroenteritis viral 12.83 10.61 69 179284 5703 29389471
Humidity intolerance 12.83 10.61 5 179348 19 29395155
Vascular shunt 12.83 10.61 5 179348 19 29395155
Exposure to fungus 12.82 10.61 4 179349 6 29395168
Blebitis 12.82 10.61 4 179349 6 29395168
Hemiparesis 12.75 10.61 45 179308 14441 29380733
Toxic encephalopathy 12.73 10.61 6 179347 4606 29390568
Miosis 12.71 10.61 18 179335 7991 29387183
Chronic respiratory disease 12.69 10.61 6 179347 40 29395134
Hypertriglyceridaemia 12.67 10.61 16 179337 7459 29387715
Toxic skin eruption 12.64 10.61 25 179328 9732 29385442
Electrocardiogram QT shortened 12.59 10.61 9 179344 140 29395034
Expiratory reserve volume decreased 12.57 10.61 6 179347 41 29395133
Multiple sclerosis relapse 12.55 10.61 32 179321 11387 29383787
Rash maculo-papular 12.48 10.61 91 179262 24198 29370976
Hyperuricaemia 12.47 10.61 14 179339 6875 29388299
Stridor 12.44 10.61 36 179317 2227 29392947
Malpositioned teeth 12.44 10.61 5 179348 21 29395153
Aphasia 12.41 10.61 67 179286 19131 29376043
Physical product label issue 12.33 10.61 3 179350 0 29395174
Flail chest 12.33 10.61 3 179350 0 29395174
Emergency care examination 12.33 10.61 3 179350 0 29395174
Ventricular pre-excitation 12.33 10.61 3 179350 0 29395174
Occupational asthma 12.33 10.61 3 179350 0 29395174
Haemolytic anaemia 12.31 10.61 24 179329 9395 29385779
Multimorbidity 12.31 10.61 16 179337 539 29394635
Limb injury 12.31 10.61 98 179255 9257 29385917
Poisoning deliberate 12.30 10.61 10 179343 5721 29389453
Tracheomalacia 12.27 10.61 9 179344 146 29395028
Contraindicated product administered 12.23 10.61 63 179290 18203 29376971
Diffuse large B-cell lymphoma 12.21 10.61 12 179341 6264 29388910
Nervous system neoplasm 12.17 10.61 9 179344 148 29395026
Hypochromasia 12.16 10.61 12 179341 297 29394877
Psychotic disorder 12.10 10.61 73 179280 20281 29374893
Nervous system disorder 12.10 10.61 38 179315 12636 29382538
Apnoeic attack 12.06 10.61 12 179341 300 29394874
Hypoalbuminaemia 12.02 10.61 28 179325 10277 29384897
Cerebrovascular accident 11.96 10.61 365 178988 76546 29318628
Melaena 11.94 10.61 126 179227 31050 29364124
Panic attack 11.94 10.61 89 179264 8237 29386937
Factor V Leiden mutation 11.88 10.61 6 179347 47 29395127
Exercise tolerance decreased 11.84 10.61 54 179299 4177 29390997
Sinus polyp 11.77 10.61 9 179344 156 29395018
Hernia pain 11.73 10.61 11 179342 255 29394919
Graft versus host disease in skin 11.73 10.61 3 179350 3376 29391798
Mouth swelling 11.66 10.61 28 179325 1548 29393626
Urticaria 11.63 10.61 423 178930 54237 29340937
Paraneoplastic rash 11.63 10.61 7 179346 80 29395094
Frustration tolerance decreased 11.60 10.61 35 179318 2217 29392957
Tracheitis 11.53 10.61 17 179336 646 29394528
Adrenocortical insufficiency acute 11.48 10.61 25 179328 1295 29393879
Communication disorder 11.47 10.61 36 179317 2329 29392845
Anal abscess 11.47 10.61 9 179344 5242 29389932
Cardiac arrest 11.46 10.61 414 178939 85177 29309997
Incorrect dose administered by product 11.44 10.61 5 179348 27 29395147
Asthenia 11.44 10.61 1137 178216 214113 29181061
Pancreatic carcinoma 11.41 10.61 16 179337 7134 29388040
Dyskinesia 11.38 10.61 73 179280 19988 29375186
Transposition of the great vessels 11.37 10.61 14 179339 446 29394728
Pharyngeal paraesthesia 11.37 10.61 14 179339 446 29394728
Stiff person syndrome 11.34 10.61 7 179346 84 29395090
Headache 11.31 10.61 1213 178140 172794 29222380
Weaning failure 11.28 10.61 10 179343 215 29394959
Aplasia pure red cell 11.27 10.61 10 179343 5481 29389693
Immune thrombocytopenia 11.26 10.61 19 179334 7858 29387316
Crying 11.25 10.61 63 179290 5288 29389886
Pigment dispersion syndrome 11.23 10.61 4 179349 11 29395163
Chest injury 11.18 10.61 26 179327 1407 29393767
Tracheostomy malfunction 11.18 10.61 6 179347 54 29395120
Bone deformity 11.18 10.61 6 179347 54 29395120
Pulmonary toxicity 11.18 10.61 8 179345 4882 29390292
Hypokalaemia 11.13 10.61 226 179127 49977 29345197
Joint swelling 11.13 10.61 223 179130 49407 29345767
Bronchopulmonary aspergillosis 11.10 10.61 38 179315 12306 29382868
Carcinoid tumour of the gastrointestinal tract 11.09 10.61 6 179347 55 29395119
Coronary artery stenosis 11.07 10.61 22 179331 8551 29386623
Atypical mycobacterial lower respiratory tract infection 11.01 10.61 5 179348 30 29395144
Drug level decreased 10.98 10.61 13 179340 6234 29388940
Electrocardiogram PR shortened 10.97 10.61 4 179349 12 29395162
Adrenal cortex necrosis 10.97 10.61 4 179349 12 29395162
Papule 10.96 10.61 3 179350 3226 29391948
Escherichia infection 10.93 10.61 15 179338 6749 29388425
Nocturnal dyspnoea 10.92 10.61 14 179339 465 29394709
Abnormal behaviour 10.88 10.61 199 179154 22928 29372246
Multiple-drug resistance 10.88 10.61 5 179348 3895 29391279
Osteopenia 10.79 10.61 52 179301 4116 29391058
Drug hypersensitivity 10.79 10.61 324 179029 68082 29327092
Retinal haemorrhage 10.79 10.61 7 179346 4497 29390677
Intentional self-injury 10.78 10.61 39 179314 12422 29382752
Central nervous system lesion 10.76 10.61 11 179342 5637 29389537
Product distribution issue 10.74 10.61 12 179341 344 29394830
Wrong technique in product usage process 10.73 10.61 258 179095 31170 29364004
Lupus pneumonitis 10.73 10.61 6 179347 59 29395115
Accelerated idioventricular rhythm 10.73 10.61 7 179346 93 29395081
Drug ineffective 10.72 10.61 1990 177363 361180 29033994
Drug ineffective for unapproved indication 10.70 10.61 47 179306 14167 29381007
Mycobacterial infection 10.67 10.61 30 179323 1826 29393348
Walking aid user 10.67 10.61 26 179327 1451 29393723
Sputum retention 10.64 10.61 13 179340 411 29394763
Endotracheal intubation 10.62 10.61 38 179315 2631 29392543
Complicated appendicitis 10.62 10.61 5 179348 33 29395141

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 6019.05 10.08 4997 420225 90228 63983282
Wheezing 3923.41 10.08 3648 421574 76931 63996579
Dyspnoea 2667.21 10.08 10542 414680 708132 63365378
Obstructive airways disorder 1980.64 10.08 1456 423766 21729 64051781
Cough 1691.37 10.08 5093 420129 297055 63776455
Poor quality device used 1513.59 10.08 550 424672 1457 64072053
Full blood count abnormal 1442.02 10.08 1345 423877 28412 64045098
Productive cough 1358.76 10.08 2021 423201 71182 64002328
Chronic obstructive pulmonary disease 1306.49 10.08 1953 423269 69095 64004415
Product quality issue 1238.66 10.08 1238 423984 28561 64044949
Forced expiratory volume decreased 1227.15 10.08 687 424535 6180 64067330
Infective pulmonary exacerbation of cystic fibrosis 1110.56 10.08 786 424436 11010 64062500
Completed suicide 1078.06 10.08 113 425109 224301 63849209
Sleep disorder due to a general medical condition 993.72 10.08 640 424582 7594 64065916
Sputum discoloured 962.62 10.08 857 424365 16999 64056511
Chest discomfort 901.13 10.08 2210 423012 113896 63959614
Toxicity to various agents 597.34 10.08 921 424301 362592 63710918
Pneumonia 595.61 10.08 5963 419259 553613 63519897
Bronchitis 493.70 10.08 1709 423513 107034 63966476
Synovitis 467.58 10.08 53 425169 99037 63974473
Off label use 464.43 10.08 2372 422850 630434 63443076
Drug abuse 433.46 10.08 165 425057 132209 63941301
Therapeutic product effect incomplete 432.62 10.08 1583 423639 101899 63971611
Nasal congestion 417.00 10.08 1092 424130 58566 64014944
Lower respiratory tract infection 407.91 10.08 1462 423760 93152 63980358
Middle insomnia 407.46 10.08 463 424759 12414 64061096
Dyspnoea exertional 388.48 10.08 1219 424003 72511 64000999
Pulmonary function test decreased 384.23 10.08 328 424894 6133 64067377
Pemphigus 382.69 10.08 3 425219 60698 64012812
Neutropenia 375.37 10.08 626 424596 238998 63834512
Treatment failure 362.31 10.08 158 425064 116658 63956852
Drug intolerance 354.96 10.08 430 424792 187562 63885948
Cystic fibrosis 354.05 10.08 242 424980 3192 64070318
Respiratory disorder 352.46 10.08 753 424469 35358 64038152
Bronchiectasis 350.22 10.08 449 424773 13691 64059819
Febrile neutropenia 339.95 10.08 443 424779 187214 63886296
Hand deformity 333.42 10.08 20 425202 62751 64010759
Nasal polyps 328.16 10.08 236 424986 3393 64070117
Drug interaction 312.09 10.08 1278 423944 360805 63712705
Thrombocytopenia 309.32 10.08 631 424591 223170 63850340
Loss of personal independence in daily activities 301.56 10.08 1107 424115 71347 64002163
Bronchospasm 301.11 10.08 525 424697 21157 64052353
Anti-cyclic citrullinated peptide antibody positive 300.97 10.08 5 425217 49557 64023953
Breath sounds abnormal 294.46 10.08 374 424848 11295 64062215
Systemic lupus erythematosus 279.75 10.08 82 425140 77530 63995980
Blood immunoglobulin E increased 274.38 10.08 217 425005 3627 64069883
Product dose omission issue 269.16 10.08 2199 423023 192548 63880962
Device delivery system issue 268.37 10.08 101 425121 305 64073205
Eosinophil count increased 259.21 10.08 388 424834 13724 64059786
Pancytopenia 253.67 10.08 344 424878 142965 63930545
Drug ineffective 250.21 10.08 3969 421253 836278 63237232
Influenza 249.58 10.08 1372 423850 105159 63968351
Arthropathy 246.43 10.08 260 424962 120707 63952803
Anaemia 235.60 10.08 1496 423726 377184 63696326
Upper respiratory tract infection 231.63 10.08 1023 424199 71762 64001748
Intentional overdose 230.23 10.08 155 425067 89789 63983721
Sleep apnoea syndrome 223.86 10.08 561 424661 29271 64044239
Pericarditis 214.67 10.08 72 425150 62444 64011066
Hepatic function abnormal 212.40 10.08 79 425143 64234 64009276
Gastrooesophageal reflux disease 207.76 10.08 1090 424132 82053 63991457
Infusion related reaction 206.31 10.08 489 424733 163978 63909532
Glossodynia 202.95 10.08 86 425136 64610 64008900
Secretion discharge 202.90 10.08 317 424905 11647 64061863
Therapeutic product effect decreased 198 10.08 283 424939 115068 63958442
Sinusitis 195.73 10.08 1637 423585 144291 63929219
Heart rate increased 194.30 10.08 1214 424008 97461 63976049
Platelet count decreased 191.54 10.08 523 424699 167188 63906322
Blood test abnormal 191.02 10.08 322 424900 12621 64060889
Malignant neoplasm progression 190.70 10.08 280 424942 112591 63960919
Respiratory tract congestion 189.77 10.08 364 424858 15801 64057709
Alopecia 184.54 10.08 523 424699 165167 63908343
Bronchopulmonary aspergillosis allergic 183.27 10.08 121 425101 1501 64072009
Malaise 183.12 10.08 3646 421576 392601 63680909
Oropharyngeal pain 176.62 10.08 1096 424126 87771 63985739
Oxygen saturation decreased 175.18 10.08 1259 423963 105917 63967593
Leukopenia 174.14 10.08 248 424974 100994 63972516
Sensitivity to weather change 169.10 10.08 215 425007 6499 64067011
Forced vital capacity decreased 168.65 10.08 112 425110 1404 64072106
Helicobacter infection 167.82 10.08 26 425196 38336 64035174
Upper-airway cough syndrome 166.63 10.08 245 424977 8525 64064985
Contraindicated product administered 164.69 10.08 286 424936 107543 63965967
Reversible airways obstruction 163.92 10.08 99 425123 1039 64072471
Bronchial wall thickening 163.31 10.08 120 425102 1787 64071723
Rales 163.14 10.08 330 424892 14899 64058611
Haemoptysis 161.83 10.08 697 424525 48351 64025159
Respiratory rate increased 161.59 10.08 367 424855 17964 64055546
Eosinophilic granulomatosis with polyangiitis 160.63 10.08 141 425081 2741 64070769
Emphysema 160.50 10.08 313 424909 13756 64059754
Food allergy 157.43 10.08 225 424997 7626 64065884
Coma 154.29 10.08 211 425011 87404 63986106
Stomatitis 153.01 10.08 307 424915 109298 63964212
Cytomegalovirus infection 152.27 10.08 30 425192 37169 64036341
White blood cell count decreased 151.30 10.08 533 424689 157304 63916206
Pulmonary function test abnormal 149.32 10.08 141 425081 3023 64070487
Anxiety 149.17 10.08 2014 423208 200635 63872875
Sputum increased 149.09 10.08 150 425072 3485 64070025
Seasonal allergy 148.80 10.08 273 424949 11453 64062057
Lung hyperinflation 148.44 10.08 106 425116 1506 64072004
Bone marrow failure 148.39 10.08 65 425157 47887 64025623
Duodenal ulcer perforation 148.03 10.08 25 425197 34600 64038910
Asthmatic crisis 147.00 10.08 109 425113 1647 64071863
Peak expiratory flow rate decreased 146.40 10.08 75 425147 553 64072957
Respiratory tract infection 145.99 10.08 560 424662 36847 64036663
Bronchial secretion retention 143.59 10.08 125 425097 2402 64071108
Hepatic enzyme increased 142.58 10.08 413 424809 129530 63943980
Renal impairment 140.35 10.08 440 424782 134577 63938933
Dust allergy 139.91 10.08 87 425135 966 64072544
Ear pain 139.19 10.08 423 424799 24713 64048797
Bronchial obstruction 138.07 10.08 119 425103 2255 64071255
Chest pain 137.62 10.08 2253 422969 233727 63839783
Bronchospasm paradoxical 135.78 10.08 47 425175 102 64073408
Sedation complication 135.11 10.08 244 424978 10110 64063400
Asthma-chronic obstructive pulmonary disease overlap syndrome 134.63 10.08 87 425135 1038 64072472
Rhinorrhoea 132.19 10.08 760 424462 59209 64014301
Hypoventilation 130.67 10.08 179 425043 5827 64067683
Eosinophil count abnormal 130.24 10.08 68 425154 524 64072986
Muscle injury 130.21 10.08 12 425210 26425 64047085
Respiration abnormal 129.61 10.08 183 425039 6132 64067378
Dysphonia 126.27 10.08 623 424599 45759 64027751
Mucosal inflammation 123.55 10.08 138 425084 62446 64011064
Rhinitis allergic 123.26 10.08 204 425018 7874 64065636
Rheumatoid arthritis 122.02 10.08 612 424610 163682 63909828
Respiratory distress 121.15 10.08 672 424550 51659 64021851
Bronchial disorder 120.94 10.08 105 425117 2010 64071500
Urticaria 120.52 10.08 1493 423729 145824 63927686
Overdose 120.45 10.08 591 424631 158975 63914535
Acute kidney injury 120.02 10.08 2162 423060 447078 63626432
Sopor 119.16 10.08 25 425197 29636 64043874
Cardio-respiratory arrest 118.25 10.08 299 424923 98094 63975416
Headache 118.15 10.08 4433 420789 525034 63548476
Product delivery mechanism issue 116.72 10.08 42 425180 107 64073403
Hepatotoxicity 116.22 10.08 59 425163 39903 64033607
Respiratory symptom 116.18 10.08 121 425101 2932 64070578
Musculoskeletal stiffness 115.43 10.08 420 424802 122786 63950724
Impaired healing 113.30 10.08 139 425083 60334 64013176
Nasopharyngitis 112.42 10.08 1867 423355 194206 63879304
Sleep disorder due to general medical condition, insomnia type 112.23 10.08 19 425203 26251 64047259
Restrictive pulmonary disease 108.68 10.08 100 425122 2072 64071438
Wound 106.90 10.08 214 425008 76263 63997247
Vital capacity decreased 106.87 10.08 74 425148 998 64072512
Temperature regulation disorder 104.72 10.08 134 425088 4077 64069433
Myelosuppression 104.58 10.08 16 425206 23814 64049696
Chronic sinusitis 104.32 10.08 165 425057 6127 64067383
Device malfunction 103.56 10.08 303 424919 17330 64056180
C-reactive protein increased 103.11 10.08 303 424919 94606 63978904
Hepatocellular injury 102.87 10.08 88 425134 45147 64028363
Hypoxia 102.67 10.08 959 424263 87190 63986320
Swollen tongue 102 10.08 479 424743 34475 64039035
Creatinine renal clearance decreased 100.73 10.08 264 424958 14157 64059353
Hospitalisation 100.39 10.08 843 424379 74364 63999146
Cerebral infarction 99.40 10.08 75 425147 40969 64032541
Drug resistance 98.87 10.08 54 425168 35048 64038462
Folliculitis 97.54 10.08 38 425184 30039 64043471
Rhonchi 97.03 10.08 117 425105 3346 64070164
Interstitial lung disease 97.02 10.08 325 424897 97407 63976103
Status asthmaticus 96.92 10.08 67 425155 901 64072609
Drug reaction with eosinophilia and systemic symptoms 96.01 10.08 130 425092 54087 64019423
Allergy to animal 96.00 10.08 68 425154 953 64072557
Septic shock 95.12 10.08 365 424857 105072 63968438
Acute respiratory failure 94.92 10.08 609 424613 49325 64024185
Drug-induced liver injury 94.10 10.08 105 425117 47538 64025972
Nasal obstruction 93.32 10.08 75 425147 1284 64072226
Joint swelling 93.31 10.08 938 424284 214444 63859066
Neuropathy peripheral 91.75 10.08 430 424792 117095 63956415
Lip swelling 91.47 10.08 435 424787 31472 64042038
Renal failure 91.38 10.08 762 424460 180926 63892584
Lower respiratory tract congestion 91.19 10.08 105 425117 2856 64070654
Anaphylactic reaction 90.76 10.08 768 424454 67896 64005614
Neutrophil count decreased 90.13 10.08 238 424984 76958 63996552
Altered state of consciousness 89.58 10.08 71 425151 37831 64035679
Polycystic ovaries 88.52 10.08 89 425133 2066 64071444
Suicide attempt 88.27 10.08 212 425010 70795 64002715
Multiple organ dysfunction syndrome 87.08 10.08 358 424864 101055 63972455
Posterior reversible encephalopathy syndrome 86.88 10.08 22 425200 22924 64050586
Serotonin syndrome 86.22 10.08 79 425143 39203 64034307
Throat clearing 85.90 10.08 71 425151 1267 64072243
Bronchial hyperreactivity 85.78 10.08 94 425128 2418 64071092
Illness 85.25 10.08 328 424894 21610 64051900
Pneumocystis jirovecii pneumonia 84.65 10.08 38 425184 27596 64045914
Rhinitis 84.51 10.08 206 425016 10559 64062951
Throat tightness 84.12 10.08 339 424883 22821 64050689
Pulmonary mass 83.64 10.08 347 424875 23669 64049841
Disease progression 82.69 10.08 570 424652 141110 63932400
Pyrexia 82.58 10.08 2934 422288 555710 63517800
Disseminated intravascular coagulation 81.08 10.08 57 425165 32291 64041219
Blood pressure systolic increased 80.79 10.08 581 424641 48872 64024638
Humidity intolerance 79.84 10.08 41 425181 304 64073206
Sinus disorder 79.48 10.08 269 424953 16639 64056871
Cerebral haemorrhage 79.36 10.08 134 425088 50956 64022554
Smoke sensitivity 79.32 10.08 46 425176 445 64073065
Agranulocytosis 79.12 10.08 81 425141 38148 64035362
Alanine aminotransferase increased 78.86 10.08 564 424658 138467 63935043
Obstruction 78.64 10.08 102 425120 3146 64070364
Death 78.13 10.08 2506 422716 480199 63593311
Total lung capacity increased 78.02 10.08 52 425170 656 64072854
Blood creatinine increased 77.90 10.08 549 424673 135233 63938277
Sinus pain 76.71 10.08 90 425132 2499 64071011
Eosinophilic bronchitis 76.62 10.08 41 425181 334 64073176
Increased bronchial secretion 76.35 10.08 94 425128 2748 64070762
Lung diffusion test decreased 75.81 10.08 63 425159 1133 64072377
Diarrhoea 75.34 10.08 3947 421275 718757 63354753
Coeliac disease 75.13 10.08 157 425065 7255 64066255
Lung consolidation 74.78 10.08 161 425061 7597 64065913
Viral infection 74.46 10.08 450 424772 35690 64037820
Blood lactate dehydrogenase increased 74.42 10.08 65 425157 33013 64040497
General physical health deterioration 74.41 10.08 926 424296 203499 63870011
Maternal exposure during pregnancy 74.14 10.08 352 424870 95532 63977978
Toxic epidermal necrolysis 73.30 10.08 82 425140 37084 64036426
Abdominal discomfort 73.26 10.08 808 424414 181514 63891996
Neurotoxicity 73.14 10.08 45 425177 27359 64046151
Circumstance or information capable of leading to medication error 71.84 10.08 99 425123 3241 64070269
Diastolic hypotension 71.31 10.08 29 425193 114 64073396
Aspartate aminotransferase increased 70.85 10.08 480 424742 119308 63954202
Sputum purulent 70.38 10.08 61 425161 1165 64072345
Sinus congestion 70.27 10.08 243 424979 15196 64058314
Rhabdomyolysis 70.18 10.08 338 424884 91388 63982122
Sleep terror 69.61 10.08 60 425162 1137 64072373
Palmar-plantar erythrodysaesthesia syndrome 69.35 10.08 53 425169 28766 64044744
Conjunctivitis allergic 68.94 10.08 56 425166 974 64072536
Poisoning 68.74 10.08 29 425193 21850 64051660
Body temperature increased 67.73 10.08 444 424778 36222 64037288
Mite allergy 67.63 10.08 48 425174 675 64072835
Spirometry abnormal 67.59 10.08 44 425178 532 64072978
Intentional product use issue 67.51 10.08 361 424861 95003 63978507
Throat irritation 67.20 10.08 407 424815 32304 64041206
Thrombotic microangiopathy 66.98 10.08 14 425208 16641 64056869
Perfume sensitivity 66.89 10.08 46 425176 613 64072897
Total lung capacity decreased 66.88 10.08 69 425153 1653 64071857
Choking 66.66 10.08 186 425036 10352 64063158
Cardiac failure 66.61 10.08 555 424667 131818 63941692
Eye pruritus 66.34 10.08 209 425013 12450 64061060
No adverse event 66.25 10.08 367 424855 28194 64045316
Neoplasm progression 65.90 10.08 105 425117 40859 64032651
Rheumatoid factor positive 65.76 10.08 80 425142 34858 64038652
Inhalation therapy 64.60 10.08 21 425201 34 64073476
Transplant rejection 63.39 10.08 18 425204 17383 64056127
Tubulointerstitial nephritis 63.39 10.08 66 425156 30843 64042667
Hepatic failure 62.98 10.08 173 425049 55221 64018289
Forced expiratory flow decreased 62.81 10.08 31 425191 209 64073301
Sneezing 62.55 10.08 232 424990 15019 64058491
Lung disorder 62.18 10.08 643 424579 60057 64013453
Arthralgia 62.05 10.08 2337 422885 439923 63633587
Palpitations 61.69 10.08 1000 424222 103488 63970022
Metastases to liver 61.59 10.08 41 425181 23900 64049610
Sensitisation 61.25 10.08 66 425156 1665 64071845
Bronchiolitis 61.08 10.08 96 425126 3545 64069965
Cystic fibrosis respiratory infection suppression 59.83 10.08 36 425186 375 64073135
Anuria 59.80 10.08 25 425197 18939 64054571
Night sweats 59.75 10.08 425 424797 35621 64037889
Swelling face 59.31 10.08 624 424598 58542 64014968
Progressive multifocal leukoencephalopathy 59.18 10.08 23 425199 18209 64055301
Pharyngeal swelling 58.99 10.08 120 425102 5439 64068071
Product container issue 58.93 10.08 49 425173 882 64072628
Osteonecrosis of jaw 58.64 10.08 108 425114 39717 64033793
Orthostatic hypotension 58.22 10.08 516 424706 46222 64027288
Acute myeloid leukaemia 58.20 10.08 57 425165 27406 64046104
Nasal turbinate hypertrophy 58.04 10.08 40 425182 535 64072975
Nasal mucosal disorder 57.99 10.08 33 425189 307 64073203
Stress 57.69 10.08 632 424590 59902 64013608
Product use in unapproved indication 57.35 10.08 819 424403 175799 63897711
Nasal discharge discolouration 57.07 10.08 64 425158 1690 64071820
Irritable bowel syndrome 56.23 10.08 100 425122 37269 64036241
Vocal cord dysfunction 56.18 10.08 35 425187 390 64073120
Blood calcium decreased 55.09 10.08 322 424900 25232 64048278
Muscle spasticity 55.06 10.08 237 424985 16432 64057078
Haemophagocytic lymphohistiocytosis 54.27 10.08 24 425198 17585 64055925
Myelodysplastic syndrome 54.22 10.08 61 425161 27518 64045992
Drug eruption 54.10 10.08 97 425125 36039 64037471
Dermatitis atopic 54.00 10.08 94 425128 3782 64069728
Venoocclusive liver disease 53.76 10.08 3 425219 10012 64063498
Fluid retention 53.48 10.08 615 424607 58991 64014519
Cholestasis 53.40 10.08 137 425085 44735 64028775
Immune reconstitution inflammatory syndrome 53.31 10.08 9 425213 12461 64061049
Respiratory failure 53.01 10.08 1415 423807 159768 63913742
Encephalopathy 52.79 10.08 204 425018 58615 64014895
Shock 52.58 10.08 108 425114 38132 64035378
Lymph node calcification 51.84 10.08 30 425192 289 64073221
Decreased appetite 50.92 10.08 1438 423784 279851 63793659
Eczema 50.77 10.08 353 424869 29367 64044143
Crepitations 50.36 10.08 140 425082 7775 64065735
Frustration tolerance decreased 50 10.08 119 425103 6006 64067504
Increased upper airway secretion 49.74 10.08 86 425136 3441 64070069
Therapy non-responder 49.73 10.08 244 424978 65655 64007855
Cardiotoxicity 49.71 10.08 5 425217 10269 64063241
Neuroleptic malignant syndrome 49.45 10.08 55 425167 24941 64048569
Hypersensitivity 49.32 10.08 1668 423554 194784 63878726
Graft versus host disease 49.02 10.08 15 425207 13798 64059712
Respiratory tract inflammation 48.81 10.08 41 425181 749 64072761
Depression 47.99 10.08 1564 423658 181727 63891783
Swelling 47.86 10.08 755 424467 159463 63914047
Infective exacerbation of chronic obstructive airways disease 47.61 10.08 69 425153 2369 64071141
Cardiac arrest 47.38 10.08 722 424500 153342 63920168
Somnolence 47.24 10.08 1003 424219 202642 63870868
Poisoning deliberate 47.07 10.08 15 425207 13443 64060067
Confusional state 46.76 10.08 1337 423885 259807 63813703
Eosinophilia 46.72 10.08 419 424803 37657 64035853
Rheumatic fever 46.36 10.08 4 425218 9290 64064220
Paranasal sinus discomfort 45.90 10.08 78 425144 3077 64070433
Migraine 45.65 10.08 622 424600 62055 64011455
Dyspnoea at rest 45.37 10.08 117 425105 6212 64067298
Multiple allergies 45.36 10.08 111 425111 5703 64067807
C-reactive protein abnormal 45.28 10.08 76 425146 28971 64044539
Liver injury 45.12 10.08 80 425142 29852 64043658
Nasal inflammation 45.06 10.08 35 425187 569 64072941
Rubber sensitivity 44.02 10.08 49 425173 1283 64072227
Right atrial hypertrophy 43.77 10.08 33 425189 512 64072998
Gamma-glutamyltransferase increased 43.69 10.08 168 425054 48342 64025168
Polyneuropathy 43.67 10.08 40 425182 19854 64053656
Burning sensation 43.47 10.08 510 424712 49154 64024356
Enthesopathy 43.39 10.08 6 425216 9632 64063878
Extrapyramidal disorder 43.29 10.08 39 425183 19513 64053997
Proteinuria 42.79 10.08 73 425149 27650 64045860
Blister 42.77 10.08 335 424887 80632 63992878
Increased viscosity of bronchial secretion 42.62 10.08 31 425191 454 64073056
Type 2 diabetes mellitus 42.58 10.08 376 424846 33644 64039866
Body temperature decreased 42.56 10.08 305 424917 25623 64047887
Balance disorder 42.25 10.08 783 424439 83143 63990367
Herpes zoster 42.13 10.08 327 424895 78860 63994650
Appendicolith 41.80 10.08 79 425143 3390 64070120
Lung neoplasm malignant 41.62 10.08 263 424959 21185 64052325
Shock haemorrhagic 41.54 10.08 30 425192 16761 64056749
Hyperkalaemia 41.46 10.08 446 424776 100683 63972827
Prolonged expiration 41.39 10.08 38 425184 785 64072725
Gastrointestinal disorder 41.20 10.08 385 424837 89324 63984186
Rash maculo-papular 40.99 10.08 165 425057 46861 64026649
Knee arthroplasty 40.84 10.08 72 425150 26927 64046583
Paraesthesia oral 40.56 10.08 183 425039 12948 64060562
Chest X-ray abnormal 40.38 10.08 116 425106 6565 64066945
Febrile bone marrow aplasia 40.34 10.08 12 425210 11243 64062267
Hypercapnia 40.29 10.08 127 425095 7567 64065943
Blood pressure increased 40.28 10.08 1453 423769 171099 63902411
FEV1/FVC ratio decreased 40.18 10.08 19 425203 115 64073395
Seizure 40.17 10.08 817 424405 166075 63907435
Cytokine release syndrome 39.94 10.08 47 425175 20782 64052728
Psoriatic arthropathy 39.55 10.08 149 425073 43132 64030378
Product complaint 39.51 10.08 170 425052 11784 64061726
Painful respiration 39.43 10.08 72 425150 3009 64070501
Drug hypersensitivity 39.23 10.08 1231 423991 236584 63836926
Haemoglobin decreased 38.99 10.08 983 424239 194080 63879430
Aspirin-exacerbated respiratory disease 38.90 10.08 43 425179 1117 64072393
Panniculitis 38.87 10.08 6 425216 8873 64064637
Limb injury 38.87 10.08 277 424945 23228 64050282
Chronic respiratory failure 38.67 10.08 65 425157 2541 64070969
Hyperammonaemia 38.46 10.08 9 425213 9895 64063615
Emotional distress 38.46 10.08 385 424837 35653 64037857
Back pain 38.20 10.08 2016 423206 248155 63825355
Airway remodelling 38.10 10.08 20 425202 156 64073354
Bradycardia 38.07 10.08 549 424673 117670 63955840
Brain oedema 38.01 10.08 54 425168 22021 64051489
Cytomegalovirus viraemia 37.99 10.08 12 425210 10816 64062694
Impaired quality of life 37.81 10.08 111 425111 6360 64067150
Colitis 37.80 10.08 229 424993 58445 64015065
Lymphopenia 37.40 10.08 70 425152 25587 64047923
Sputum abnormal 37.35 10.08 39 425183 948 64072562
Pathogen resistance 37.25 10.08 18 425204 12525 64060985
Drug level increased 37.25 10.08 109 425113 34087 64039423
Tumour lysis syndrome 37.13 10.08 44 425178 19396 64054114
Ejection fraction 36.93 10.08 44 425178 1242 64072268
Product taste abnormal 36.68 10.08 55 425167 1948 64071562
Red blood cell sedimentation rate increased 36.68 10.08 96 425126 31139 64042371
Respiratory tract irritation 36.50 10.08 30 425192 531 64072979
Hyperbilirubinaemia 36.38 10.08 52 425170 21153 64052357
Anosmia 36.26 10.08 86 425136 4331 64069179
Sinus operation 36.10 10.08 50 425172 1645 64071865
Incorrect dose administered 36.02 10.08 582 424640 60183 64013327
Hip arthroplasty 36.00 10.08 53 425169 21298 64052212
Bradyphrenia 35.64 10.08 9 425213 9397 64064113
Epstein-Barr virus infection 35.48 10.08 19 425203 12469 64061041
Factitious disorder 35.45 10.08 18 425204 130 64073380
Disorientation 35.39 10.08 219 425003 55609 64017901
Suspected suicide 35.37 10.08 7 425215 8647 64064863
Hepatitis cholestatic 35.26 10.08 18 425204 12137 64061373
Insomnia 35.14 10.08 1618 423604 196218 63877292
Hypercalcaemia 35.05 10.08 99 425123 31317 64042193
Drug ineffective for unapproved indication 34.82 10.08 98 425124 31035 64042475
Aplasia 34.66 10.08 3 425219 6950 64066560
Cholecystitis chronic 34.57 10.08 137 425085 9150 64064360
Nightmare 34.49 10.08 247 424975 20746 64052764
Hyperthermia 34.45 10.08 31 425191 15519 64057991
Pharyngeal oedema 34.32 10.08 197 425025 15334 64058176
Ulcer 34.16 10.08 62 425160 22928 64050582
Nasal disorder 33.92 10.08 65 425157 2819 64070691
Bronchomalacia 33.76 10.08 20 425202 202 64073308
Pulmonary congestion 33.63 10.08 271 424951 23609 64049901
Tenosynovitis 33.62 10.08 18 425204 11815 64061695
Rash erythematous 33.54 10.08 478 424744 48155 64025355
Rhinovirus infection 33.52 10.08 103 425119 6053 64067457
Discomfort 33.43 10.08 356 424866 80522 63992988
Transplant dysfunction 33.15 10.08 3 425219 6705 64066805
Transaminases increased 33.13 10.08 166 425056 44428 64029082
Eye swelling 33.11 10.08 256 424966 22025 64051485
Exercise tolerance decreased 33.06 10.08 119 425103 7591 64065919
Wolff-Parkinson-White syndrome 33.04 10.08 21 425201 243 64073267
Polyp 32.99 10.08 108 425114 6565 64066945
Aphonia 32.95 10.08 129 425093 8568 64064942
Immunodeficiency 32.72 10.08 200 425022 15924 64057586
Status epilepticus 32.56 10.08 58 425164 21605 64051905
Acute hepatic failure 32.41 10.08 78 425144 26034 64047476
Feeling abnormal 32.40 10.08 1130 424092 132472 63941038
Infection 32.20 10.08 950 424272 183930 63889580
Blood parathyroid hormone decreased 32.20 10.08 5 425217 7361 64066149
Neurodevelopmental disorder 32.19 10.08 12 425210 35 64073475
Leukoencephalopathy 32.17 10.08 4 425218 6963 64066547
Prescribed underdose 32.09 10.08 43 425179 17972 64055538
Akathisia 31.99 10.08 18 425204 11492 64062018
Pruritus 31.97 10.08 2432 422790 309968 63763542
Liver disorder 31.92 10.08 213 425009 53138 64020372
Animal scratch 31.91 10.08 36 425186 957 64072553
Bronchial neoplasm 31.60 10.08 25 425197 418 64073092
Metabolic acidosis 31.53 10.08 307 424915 70651 64002859
Acute graft versus host disease in skin 31.50 10.08 4 425218 6851 64066659
Atelectasis 31.40 10.08 296 424926 26970 64046540
Hyper IgE syndrome 31.22 10.08 26 425196 469 64073041
Lung diffusion test abnormal 31.21 10.08 17 425205 144 64073366
Idiopathic intracranial hypertension 31.18 10.08 59 425163 2534 64070976
Hypertensive crisis 31.06 10.08 45 425177 18203 64055307
Spinal muscular atrophy 30.98 10.08 21 425201 273 64073237
Peritonitis 30.86 10.08 75 425147 24948 64048562
Exposure to allergen 30.62 10.08 18 425204 179 64073331
Intentional product misuse 30.37 10.08 317 424905 71978 64001532
Sedation 30.00 10.08 411 424811 41051 64032459
Intentional self-injury 29.90 10.08 95 425127 28949 64044561
Mucormycosis 29.87 10.08 6 425216 7335 64066175
Hypoalbuminaemia 29.68 10.08 44 425178 17630 64055880
Blood creatine phosphokinase increased 29.67 10.08 245 424977 58313 64015197
Toxic skin eruption 29.56 10.08 51 425171 19233 64054277
Multiple-drug resistance 29.38 10.08 4 425218 6498 64067012
Enteritis 29.33 10.08 22 425200 12055 64061455
Forced expiratory volume abnormal 29.31 10.08 14 425208 87 64073423
Mouth swelling 29.26 10.08 87 425135 5020 64068490
Lung opacity 29.26 10.08 65 425157 3134 64070376
Kidney transplant rejection 29.25 10.08 13 425209 9498 64064012
Broncholithiasis 29.23 10.08 16 425206 137 64073373
Injury 29.09 10.08 525 424697 55467 64018043
Blood bilirubin increased 29.07 10.08 241 424981 57312 64016198
Hiatus hernia 28.94 10.08 228 424994 19729 64053781
Unintentional medical device removal 28.48 10.08 5 425217 6729 64066781
Sputum retention 28.47 10.08 33 425189 904 64072606
Multiple sclerosis relapse 28.39 10.08 157 425065 40978 64032532
Hepatitis B 28.23 10.08 8 425214 7737 64065773
Aplastic anaemia 28.23 10.08 30 425192 13890 64059620
Ataxia 28.18 10.08 65 425157 22019 64051491
Nasal oedema 28.15 10.08 34 425188 974 64072536
Ejection fraction decreased 28.11 10.08 96 425126 28611 64044899
Nephropathy toxic 28.07 10.08 45 425177 17469 64056041
Cognitive disorder 27.74 10.08 514 424708 54573 64018937
Pickwickian syndrome 27.65 10.08 22 425200 371 64073139
Klebsiella infection 27.64 10.08 28 425194 13253 64060257
Nasal septum deviation 27.63 10.08 42 425180 1506 64072004
Osteoporosis 27.60 10.08 410 424812 41670 64031840
Cystitis haemorrhagic 27.59 10.08 9 425213 7947 64065563
Sepsis 27.57 10.08 1239 423983 229102 63844408
Constipation 27.54 10.08 1809 423413 227528 63845982
Distal intestinal obstruction syndrome 27.41 10.08 27 425195 611 64072899
Eosinophil count 27.24 10.08 14 425208 104 64073406
Salpingo-oophorectomy unilateral 27.11 10.08 24 425198 472 64073038
Therapy partial responder 27.11 10.08 17 425205 10231 64063279
Metastases to bone 27.01 10.08 59 425163 20376 64053134
Panic attack 26.96 10.08 233 424989 20720 64052790
Diastolic dysfunction 26.90 10.08 123 425099 8752 64064758
Enterococcal infection 26.90 10.08 31 425191 13835 64059675
Blood cholesterol 26.85 10.08 21 425201 345 64073165
Blood iron decreased 26.82 10.08 154 425068 11988 64061522
Decreased activity 26.79 10.08 106 425116 7074 64066436
Skin necrosis 26.76 10.08 33 425189 14296 64059214
Right ventricular hypertrophy 26.72 10.08 38 425184 1282 64072228
Renal tubular necrosis 26.69 10.08 67 425155 22043 64051467
Subdural haematoma 26.67 10.08 95 425127 27959 64045551
Metastases to lung 26.62 10.08 37 425185 15227 64058283
Dehydration 26.55 10.08 1163 424059 215600 63857910
Dizziness 26.51 10.08 3231 421991 426932 63646578
BK virus infection 26.39 10.08 8 425214 7404 64066106
Diffuse large B-cell lymphoma 26.31 10.08 18 425204 10343 64063167
Joint range of motion decreased 26.28 10.08 55 425167 19288 64054222
Congenital hiatus hernia 26.28 10.08 22 425200 400 64073110
Rebound nasal congestion 26.17 10.08 9 425213 19 64073491
Psychotic disorder 26.10 10.08 128 425094 34450 64039060
Epilepsy 25.96 10.08 123 425099 33408 64040102
Sinusitis fungal 25.92 10.08 43 425179 1663 64071847
Atopy 25.79 10.08 18 425204 246 64073264
Oliguria 25.75 10.08 35 425187 14541 64058969
Subarachnoid haemorrhage 25.41 10.08 52 425170 18386 64055124
Rhinitis perennial 25.40 10.08 17 425205 216 64073294
Victim of child abuse 25.34 10.08 30 425192 841 64072669
Accidental exposure to product 25.25 10.08 89 425133 26275 64047235
Hypertransaminasaemia 25.18 10.08 8 425214 7183 64066327
Exposure to toxic agent 25.13 10.08 5 425217 6154 64067356
Influenza B virus test positive 24.95 10.08 20 425202 341 64073169
Dermatitis allergic 24.95 10.08 178 425044 14931 64058579
Respiratory arrest 24.92 10.08 226 424996 52759 64020751
Carbon dioxide increased 24.85 10.08 46 425176 1943 64071567
Femur fracture 24.83 10.08 128 425094 34007 64039503
Bursitis 24.62 10.08 233 424989 21252 64052258
Foreign body in reproductive tract 24.59 10.08 22 425200 439 64073071
Blood pressure fluctuation 24.51 10.08 221 425001 51650 64021860
Blood alkaline phosphatase increased 24.37 10.08 245 424977 56034 64017476
Muscle rigidity 24.31 10.08 49 425173 17424 64056086
Rectal prolapse 24.23 10.08 42 425180 1684 64071826
Pulmonary pain 24.19 10.08 53 425169 2531 64070979
Drug tolerance decreased 24.12 10.08 8 425214 6990 64066520
Haemolytic anaemia 24.11 10.08 43 425179 16010 64057500
Lung diffusion disorder 24.08 10.08 13 425209 108 64073402
Haematochezia 23.98 10.08 301 424921 66072 64007438
Haemorrhage intracranial 23.98 10.08 79 425143 23805 64049705
Basal cell carcinoma 23.95 10.08 113 425109 30725 64042785
Generalised tonic-clonic seizure 23.90 10.08 159 425063 39698 64033812
Nausea 23.78 10.08 4695 420527 781105 63292405
Urinary tract discomfort 23.75 10.08 19 425203 323 64073187
Skin toxicity 23.74 10.08 7 425215 6595 64066915
Sinus tachycardia 23.66 10.08 320 424902 31868 64041642
Depressed mood 23.63 10.08 391 424831 40621 64032889
Alanine aminotransferase abnormal 23.52 10.08 8 425214 6880 64066630
Oxygen consumption increased 23.42 10.08 75 425147 4506 64069004
Weight decreased 23.30 10.08 2187 423035 283552 63789958
Respiratory acidosis 23.10 10.08 127 425095 9728 64063782
Osteonecrosis 22.78 10.08 102 425120 28127 64045383
Oesophageal spasm 22.75 10.08 51 425171 2474 64071036
Cytopenia 22.74 10.08 42 425180 15429 64058081
Rheumatoid nodule 22.73 10.08 30 425192 12621 64060889
Nystagmus 22.70 10.08 16 425206 9052 64064458
Lower respiratory tract infection bacterial 22.63 10.08 25 425197 649 64072861
Uterine perforation 22.59 10.08 87 425135 5733 64067777
Ventricular failure 22.58 10.08 22 425200 491 64073019
Inflammation 22.54 10.08 299 424923 65001 64008509
Cardiac disorder 22.53 10.08 504 424718 55312 64018198
Fracture 22.51 10.08 57 425165 18698 64054812
Forced expiratory volume increased 22.40 10.08 9 425213 34 64073476
Injection site reaction 22.40 10.08 198 425024 46466 64027044
Delirium 22.39 10.08 321 424901 68873 64004637
Jaundice 22.35 10.08 208 425014 48304 64025206
Respiratory syncytial virus bronchiolitis 22.32 10.08 21 425201 448 64073062
Alveolar osteitis 22.23 10.08 20 425202 402 64073108
Hepatitis B reactivation 22.11 10.08 3 425219 4886 64068624
Osteomyelitis 22.07 10.08 100 425122 27487 64046023
Drug dependence 22.01 10.08 325 424897 32987 64040523
Graft versus host disease in gastrointestinal tract 21.99 10.08 5 425217 5607 64067903
Uveitis 21.96 10.08 31 425191 12677 64060833
Pulmonary hypertension 21.88 10.08 403 424819 42736 64030774
Skin ulcer 21.82 10.08 185 425037 43789 64029721
Nephrectomy 21.81 10.08 36 425186 1386 64072124
Aphthous ulcer 21.80 10.08 32 425190 12874 64060636
Cockroach allergy 21.71 10.08 11 425211 79 64073431
Cystic fibrosis related diabetes 21.67 10.08 14 425208 167 64073343
Crying 21.61 10.08 215 425007 19875 64053635
Forced expiratory volume 21.60 10.08 11 425211 80 64073430
Stridor 21.56 10.08 76 425146 4798 64068712
Oral candidiasis 21.49 10.08 241 424981 22971 64050539
Pulmonary embolism 21.43 10.08 1175 424047 145181 63928329
Retinal haemorrhage 21.39 10.08 11 425211 7387 64066123
Anger 21.29 10.08 177 425045 15564 64057946
Cervix neoplasm 21.05 10.08 14 425208 176 64073334
Ileus 21.02 10.08 79 425143 22887 64050623
Blood immunoglobulin E decreased 20.93 10.08 11 425211 86 64073424
Stress cardiomyopathy 20.84 10.08 118 425104 9139 64064371
Decreased bronchial secretion 20.82 10.08 10 425212 63 64073447
Jaundice cholestatic 20.79 10.08 16 425206 8654 64064856
Labelled drug-drug interaction medication error 20.78 10.08 75 425147 21987 64051523
Endometrial ablation 20.73 10.08 26 425196 775 64072735
Eosinophilic oesophagitis 20.61 10.08 20 425202 444 64073066
Nervousness 20.58 10.08 291 424931 29265 64044245
Hyposmia 20.57 10.08 22 425200 550 64072960
Injection site pain 20.51 10.08 568 424654 110840 63962670
Squamous cell carcinoma of skin 20.50 10.08 29 425193 11847 64061663
Incorrect dose administered by product 20.48 10.08 13 425209 150 64073360
Suffocation feeling 20.42 10.08 37 425185 1537 64071973
Pulmonary toxicity 20.27 10.08 16 425206 8545 64064965
Respiratory tract infection bacterial 20.17 10.08 26 425196 797 64072713
Respiratory syncytial virus infection 20.04 10.08 98 425124 7170 64066340
Cytomegalovirus chorioretinitis 20.02 10.08 4 425218 4908 64068602
Foreign body aspiration 20.00 10.08 16 425206 272 64073238
Dermatitis exfoliative generalised 19.98 10.08 7 425215 5909 64067601
Angle closure glaucoma 19.96 10.08 50 425172 2607 64070903
Central obesity 19.90 10.08 35 425187 1420 64072090
Metastases to lymph nodes 19.76 10.08 17 425205 8700 64064810
Multiple drug therapy 19.72 10.08 45 425177 2209 64071301
Product administered to patient of inappropriate age 19.72 10.08 71 425151 4530 64068980
Respiratory tract infection viral 19.57 10.08 49 425173 2554 64070956
Inappropriate antidiuretic hormone secretion 19.55 10.08 78 425144 22211 64051299
Hyperuricaemia 19.53 10.08 23 425199 10168 64063342
Myoclonus 19.53 10.08 92 425130 25026 64048484
Device related infection 19.48 10.08 120 425102 30506 64043004
Aplasia pure red cell 19.45 10.08 11 425211 7003 64066507
Arthritis bacterial 19.40 10.08 14 425208 7825 64065685
Embolism venous 19.39 10.08 59 425163 3448 64070062
Psychomotor retardation 19.34 10.08 5 425217 5138 64068372
Bronchitis bacterial 19.33 10.08 32 425190 1235 64072275
Coagulopathy 19.31 10.08 127 425095 31793 64041717
Pemphigoid 19.31 10.08 35 425187 12951 64060559
Urinary tract infection 19.30 10.08 1291 423931 230305 63843205
Oropharyngeal discomfort 19.30 10.08 78 425144 5257 64068253
Obesity 19.27 10.08 214 425008 20348 64053162
Vocal cord disorder 19.27 10.08 33 425189 1310 64072200
Cardiac failure congestive 19.24 10.08 1049 424173 129531 63943979
Oxygen therapy 19.21 10.08 45 425177 2248 64071262
Haemophilus infection 19.19 10.08 40 425182 1845 64071665
Lymphoproliferative disorder 19.11 10.08 5 425217 5098 64068412
Attention-seeking behaviour 19.09 10.08 11 425211 105 64073405
Temperature intolerance 19.09 10.08 106 425116 8149 64065361
Hepatic cytolysis 19.04 10.08 40 425182 14009 64059501
Device defective 19.04 10.08 32 425190 1251 64072259
Haemolysis 19.01 10.08 27 425195 11012 64062498
Toxic encephalopathy 18.98 10.08 22 425200 9793 64063717
Gallbladder injury 18.89 10.08 30 425192 1118 64072392
Use of accessory respiratory muscles 18.85 10.08 17 425205 343 64073167
Mydriasis 18.80 10.08 46 425176 15266 64058244
Pneumonia pseudomonal 18.80 10.08 73 425149 4830 64068680
Eosinophilic pneumonia chronic 18.64 10.08 17 425205 348 64073162
Graft versus host disease in skin 18.63 10.08 6 425216 5341 64068169
Lip discolouration 18.61 10.08 22 425200 616 64072894
Respiratory gas exchange disorder 18.48 10.08 24 425198 741 64072769
Superinfection 18.42 10.08 62 425160 3824 64069686
Stevens-Johnson syndrome 18.41 10.08 141 425081 34108 64039402
Cor pulmonale 18.36 10.08 41 425181 1984 64071526
Acute respiratory distress syndrome 18.34 10.08 166 425056 38769 64034741
Familial periodic paralysis 18.30 10.08 12 425210 147 64073363
Dyskinesia 18.09 10.08 169 425053 39219 64034291
Total lung capacity abnormal 18.03 10.08 12 425210 151 64073359
Increased viscosity of upper respiratory secretion 18.00 10.08 14 425208 228 64073282
Hypocalcaemia 17.98 10.08 182 425040 41571 64031939
Small airways disease 17.94 10.08 7 425215 24 64073486
Right atrial enlargement 17.89 10.08 16 425206 319 64073191
Anal abscess 17.82 10.08 14 425208 7494 64066016
Rash 17.81 10.08 2702 422520 455847 63617663
Substance abuse 17.78 10.08 21 425201 9271 64064239
Gastric haemorrhage 17.76 10.08 39 425183 13442 64060068
Nasal mucosal discolouration 17.73 10.08 7 425215 25 64073485
Hypothermia 17.72 10.08 69 425153 19787 64053723
Encephalitis 17.71 10.08 35 425187 12536 64060974
Intentional device misuse 17.69 10.08 22 425200 650 64072860
Pregnancy 17.68 10.08 74 425148 20791 64052719
Bacterial disease carrier 17.68 10.08 27 425195 972 64072538
Pneumonia lipoid 17.57 10.08 12 425210 158 64073352
Electrocardiogram QRS complex prolonged 17.57 10.08 21 425201 9223 64064287
Ascites 17.56 10.08 295 424927 61706 64011804
Snoring 17.37 10.08 69 425153 4613 64068897
Enterocolitis 17.33 10.08 33 425189 11985 64061525
Separation anxiety disorder 17.31 10.08 7 425215 27 64073483
Skin candida 17.17 10.08 36 425186 1667 64071843
International normalised ratio increased 17.16 10.08 394 424828 78773 63994737
Erythema multiforme 17.13 10.08 50 425172 15651 64057859
Drug level decreased 17.11 10.08 31 425191 11472 64062038
Alcohol interaction 17.09 10.08 4 425218 4397 64069113
Hepatitis toxic 17.08 10.08 4 425218 4396 64069114
Appetite disorder 17.02 10.08 86 425136 6375 64067135
Acute lymphocytic leukaemia recurrent 17.00 10.08 3 425219 4023 64069487
Functional residual capacity increased 16.96 10.08 9 425213 72 64073438
Cerebellar syndrome 16.83 10.08 6 425216 5010 64068500
Ischaemic stroke 16.83 10.08 117 425105 28918 64044592
Blood urea increased 16.80 10.08 198 425024 43955 64029555
Hereditary angioedema 16.77 10.08 60 425162 3816 64069694
Parathyroid gland enlargement 16.76 10.08 11 425211 135 64073375
Magnetic resonance imaging thoracic abnormal 16.75 10.08 6 425216 15 64073495
Croup infectious 16.72 10.08 20 425202 567 64072943
Lupus-like syndrome 16.68 10.08 20 425202 8771 64064739
Thunderclap headache 16.65 10.08 13 425209 213 64073297
Hypotension 16.63 10.08 2229 422993 378745 63694765
Peripheral sensory neuropathy 16.62 10.08 31 425191 11347 64062163
Pulmonary tuberculosis 16.58 10.08 14 425208 7230 64066280
Gastroenteritis viral 16.56 10.08 201 425021 19528 64053982
PCO2 increased 16.53 10.08 35 425187 1632 64071878
Injection site scab 16.49 10.08 15 425207 306 64073204
Wrong technique in device usage process 16.42 10.08 49 425173 2833 64070677
Pharyngeal erythema 16.38 10.08 36 425186 1723 64071787
Injection site erythema 16.31 10.08 349 424873 70451 64003059
Tachypnoea 16.31 10.08 256 424966 26315 64047195
Sarcopenia 16.28 10.08 16 425206 361 64073149
Bed bug infestation 16.24 10.08 5 425217 6 64073504
Tongue pruritus 16.21 10.08 18 425204 470 64073040
Neutropenic colitis 16.21 10.08 5 425217 4576 64068934
Bronchial haemorrhage 16.20 10.08 29 425193 1193 64072317
Nasal pruritus 16.17 10.08 16 425206 364 64073146
Biliary dyskinesia 16.13 10.08 43 425179 2329 64071181
Ileus paralytic 16.12 10.08 19 425203 8396 64065114
Influenza immunisation 16.11 10.08 4 425218 0 64073510
Self-injurious ideation 16.04 10.08 52 425170 3145 64070365
Disease complication 16.03 10.08 63 425159 4192 64069318
Pseudomonal sepsis 16.02 10.08 7 425215 5165 64068345
Mood swings 16.01 10.08 181 425041 17287 64056223
Expired product administered 15.99 10.08 80 425142 5907 64067603
Bronchopulmonary aspergillosis 15.98 10.08 68 425154 19017 64054493
Hypertriglyceridaemia 15.96 10.08 31 425191 11174 64062336
Visual acuity reduced 15.91 10.08 109 425113 27032 64046478
Bacterial tracheitis 15.89 10.08 7 425215 35 64073475
Cytomegalovirus test positive 15.87 10.08 7 425215 5137 64068373
Ear discomfort 15.86 10.08 92 425130 7188 64066322
Nicotine dependence 15.84 10.08 23 425199 791 64072719
Infective exacerbation of bronchiectasis 15.83 10.08 22 425200 726 64072784
Electrocardiogram U-wave abnormality 15.79 10.08 9 425213 84 64073426
Encephalitis toxic 15.74 10.08 14 425208 277 64073233
Tooth disorder 15.74 10.08 85 425137 22317 64051193
Sleep disorder 15.73 10.08 510 424712 59199 64014311
Gait disturbance 15.65 10.08 952 424270 171203 63902307
Decreased gait velocity 15.60 10.08 11 425211 153 64073357
Rib deformity 15.57 10.08 10 425212 118 64073392
Nocturnal dyspnoea 15.48 10.08 30 425192 1312 64072198
Sinus polyp 15.46 10.08 17 425205 439 64073071
Exposure to fungus 15.44 10.08 9 425213 88 64073422
Vascular shunt 15.42 10.08 7 425215 38 64073472
Hydronephrosis 15.40 10.08 45 425177 14080 64059430
Pancreatic carcinoma 15.39 10.08 28 425194 10345 64063165
Escherichia infection 15.35 10.08 50 425172 15118 64058392
Ear infection 15.33 10.08 228 424994 23176 64050334
Bacteraemia 15.32 10.08 109 425113 26802 64046708
Squamous cell carcinoma 15.25 10.08 44 425178 13825 64059685
Hepatic cirrhosis 15.23 10.08 106 425116 26192 64047318
Second primary malignancy 15.19 10.08 37 425185 12300 64061210
Dermatitis acneiform 15.19 10.08 20 425202 8423 64065087
Emergency care examination 15.18 10.08 8 425214 63 64073447
Device ineffective 15.15 10.08 10 425212 124 64073386
Cerebral haematoma 15.12 10.08 15 425207 7170 64066340
Product prescribing issue 15.07 10.08 40 425182 2161 64071349
Product cleaning inadequate 15.05 10.08 5 425217 9 64073501
Mycobacterium test positive 15.03 10.08 16 425206 398 64073112
Hemiparesis 15.01 10.08 125 425097 29702 64043808
Urinary retention 14.96 10.08 231 424991 48970 64024540
Mycotic allergy 14.95 10.08 25 425197 973 64072537
Functional residual capacity decreased 14.87 10.08 8 425214 66 64073444
Pharyngitis streptococcal 14.83 10.08 103 425119 8565 64064945
Cystic fibrosis lung 14.75 10.08 10 425212 130 64073380
Bronchial irritation 14.72 10.08 7 425215 43 64073467
Asthma exercise induced 14.70 10.08 9 425213 97 64073413
Heart sounds 14.70 10.08 19 425203 584 64072926
Hypoacusis 14.67 10.08 246 424976 25621 64047889
Autoimmune haemolytic anaemia 14.63 10.08 15 425207 7061 64066449
Neurosensory hypoacusis 14.62 10.08 12 425210 212 64073298
Acute graft versus host disease in intestine 14.58 10.08 3 425219 3606 64069904
Haematuria 14.54 10.08 296 424926 60175 64013335
Feeling cold 14.48 10.08 228 424994 23450 64050060
Reversible cerebral vasoconstriction syndrome 14.48 10.08 41 425181 2301 64071209
Haematoma 14.46 10.08 216 425006 46034 64027476
Vertigo 14.45 10.08 288 424934 58723 64014787
Cytomegalovirus colitis 14.43 10.08 4 425218 3924 64069586
Accessory spleen 14.41 10.08 11 425211 174 64073336
Complications of transplanted kidney 14.40 10.08 9 425213 5426 64068084
Immune thrombocytopenia 14.33 10.08 51 425171 15015 64058495
Gingival bleeding 14.32 10.08 50 425172 14804 64058706
Product use issue 14.32 10.08 836 424386 150879 63922631
Adenovirus infection 14.31 10.08 16 425206 7239 64066271
Hypopnoea 14.30 10.08 50 425172 3144 64070366
Pneumonia aspiration 14.29 10.08 290 424932 58981 64014529
Duodenal ulcer repair 14.28 10.08 8 425214 72 64073438
Renal injury 14.17 10.08 53 425169 15376 64058134
Cerebrovascular accident 14.11 10.08 752 424470 136831 63936679
Nephrotic syndrome 14.03 10.08 26 425196 9541 64063969
Intervertebral discitis 14.03 10.08 4 425218 3853 64069657
Hepatocellular carcinoma 14.03 10.08 21 425201 8382 64065128
Brain abscess 14.03 10.08 5 425217 4176 64069334
Hyperpyrexia 14.02 10.08 8 425214 5069 64068441
Brain injury 13.98 10.08 113 425109 9852 64063658
Hepatosplenomegaly 13.95 10.08 9 425213 5334 64068176
Kyphosis 13.94 10.08 41 425181 2352 64071158
Soft tissue mass 13.93 10.08 23 425199 886 64072624
Cerebral artery thrombosis 13.87 10.08 25 425197 1034 64072476
Oesophageal carcinoma 13.83 10.08 65 425157 4678 64068832
Tunnel vision 13.77 10.08 25 425197 1040 64072470
Acute generalised exanthematous pustulosis 13.77 10.08 47 425175 14011 64059499
Clostridium difficile colitis 13.74 10.08 114 425108 27109 64046401
Joint stiffness 13.73 10.08 131 425091 30273 64043237
Oesophageal polyp 13.62 10.08 7 425215 52 64073458
Cardiac murmur 13.55 10.08 126 425096 11437 64062073
Wrong patient received product 13.50 10.08 4 425218 3758 64069752
Varicella zoster gastritis 13.46 10.08 6 425216 31 64073479
Herpes simplex 13.45 10.08 31 425191 10505 64063005
Burns third degree 13.44 10.08 15 425207 394 64073116
Oxygen saturation 13.43 10.08 12 425210 239 64073271
Sinus bradycardia 13.39 10.08 92 425130 22801 64050709
Tracheal disorder 13.38 10.08 15 425207 396 64073114
Allergic cough 13.37 10.08 16 425206 454 64073056
Cell death 13.35 10.08 5 425217 4049 64069461
Accidental overdose 13.34 10.08 149 425073 33408 64040102
Brain scan abnormal 13.34 10.08 26 425196 1142 64072368
Inspiratory capacity abnormal 13.32 10.08 8 425214 83 64073427
Nasal turbinate abnormality 13.31 10.08 5 425217 15 64073495
Atypical mycobacterial lower respiratory tract infection 13.29 10.08 7 425215 55 64073455
Malignant mediastinal neoplasm 13.29 10.08 17 425205 517 64072993
Mixed liver injury 13.29 10.08 10 425212 5471 64068039
Miosis 13.23 10.08 44 425178 13222 64060288
Upper respiratory fungal infection 13.20 10.08 13 425209 294 64073216
Haemodynamic instability 13.20 10.08 52 425170 14860 64058650
Spinal pain 13.19 10.08 41 425181 12580 64060930
Renal tubular disorder 13.18 10.08 12 425210 5975 64067535
Epidural lipomatosis 13.18 10.08 22 425200 855 64072655
Tuberculosis 13.18 10.08 43 425179 12995 64060515
Allergic sinusitis 13.15 10.08 16 425206 462 64073048
Granulocytopenia 13.10 10.08 31 425191 10409 64063101
Panic reaction 13.10 10.08 57 425165 3970 64069540
Foot deformity 13.10 10.08 60 425162 16444 64057066
Suicidal ideation 13.07 10.08 550 424672 65992 64007518
Procedural pain 13.02 10.08 158 425064 15350 64058160
Overweight 12.98 10.08 50 425172 3296 64070214
Blood cholesterol increased 12.97 10.08 242 424980 49824 64023686
Muscle spasms 12.95 10.08 1089 424133 139934 63933576
Pyelonephritis acute 12.93 10.08 9 425213 5125 64068385
Benign prostatic hyperplasia 12.90 10.08 104 425118 9061 64064449
Hypoglycaemic coma 12.90 10.08 6 425216 4268 64069242
Tremor 12.89 10.08 1140 424082 147090 63926420
Musculoskeletal pain 12.85 10.08 423 424799 80871 63992639
Hypomania 12.85 10.08 11 425211 5643 64067867
Acute sinusitis 12.82 10.08 58 425164 4108 64069402
Capillary leak syndrome 12.80 10.08 3 425219 3294 64070216
Endophthalmitis 12.74 10.08 10 425212 5355 64068155
Restlessness 12.72 10.08 185 425037 39600 64033910
Mucosal discolouration 12.68 10.08 20 425202 741 64072769
Enterovirus infection 12.65 10.08 29 425193 1428 64072082
Stoma closure 12.60 10.08 9 425213 128 64073382
Chest injury 12.59 10.08 40 425182 2393 64071117
Lung hernia 12.59 10.08 7 425215 62 64073448
Incorrect dose administered by device 12.58 10.08 57 425165 4040 64069470
Ventricular hyperkinesia 12.57 10.08 12 425210 261 64073249
Oral pruritus 12.56 10.08 33 425189 1772 64071738
Personal relationship issue 12.55 10.08 10 425212 169 64073341
Bladder prolapse 12.55 10.08 25 425197 1116 64072394
Sinus headache 12.53 10.08 58 425164 4149 64069361
Pneumothorax spontaneous 12.50 10.08 24 425198 1042 64072468
Hilar lymphadenopathy 12.49 10.08 30 425192 1523 64071987
Breath alcohol test positive 12.49 10.08 4 425218 6 64073504
Vaccination site warmth 12.49 10.08 4 425218 6 64073504
Nocardiosis 12.48 10.08 8 425214 4759 64068751
Musculoskeletal chest pain 12.45 10.08 205 425017 21274 64052236
Skin erosion 12.40 10.08 5 425217 3871 64069639
Cholecystectomy 12.33 10.08 93 425129 7939 64065571
Urosepsis 12.33 10.08 90 425132 22004 64051506
Hypoglycaemia 12.33 10.08 476 424746 89416 63984094
Metastases to peritoneum 12.32 10.08 4 425218 3543 64069967
Carcinoid tumour pulmonary 12.32 10.08 13 425209 320 64073190
Oropharyngitis fungal 12.31 10.08 7 425215 65 64073445
Oxygen consumption decreased 12.30 10.08 14 425208 376 64073134
Impaired work ability 12.27 10.08 55 425167 15164 64058346
Choking sensation 12.25 10.08 51 425171 3484 64070026
Neurological decompensation 12.24 10.08 7 425215 4429 64069081
Tracheomalacia 12.23 10.08 11 425211 221 64073289
Flour sensitivity 12.23 10.08 5 425217 20 64073490
Mood altered 12.22 10.08 160 425062 15819 64057691
Anal fistula 12.21 10.08 10 425212 5243 64068267
Loss of consciousness 12.19 10.08 828 424394 147537 63925973
Subileus 12.17 10.08 9 425213 4968 64068542
Myalgia 12.16 10.08 1209 424013 157408 63916102
Coronary artery stenosis 12.14 10.08 36 425186 11212 64062298
Lacrimation increased 12.12 10.08 179 425043 18167 64055343
Influenza like illness 12.12 10.08 510 424712 61192 64012318
Aptyalism 12.12 10.08 19 425203 700 64072810
Noninfective bronchitis 12.09 10.08 3 425219 0 64073510
Ventricular pre-excitation 12.09 10.08 3 425219 0 64073510
Breath sounds 12.08 10.08 9 425213 137 64073373
Peritonitis bacterial 12.04 10.08 26 425196 9017 64064493
Central nervous system lesion 12.03 10.08 39 425183 11810 64061700
Cortisol decreased 12.02 10.08 31 425191 1646 64071864
Dermatitis exfoliative 12.01 10.08 32 425190 10320 64063190
Metastases to central nervous system 12.00 10.08 49 425173 13863 64059647
Colitis microscopic 12.00 10.08 19 425203 7413 64066097
Pancreatitis 12.00 10.08 300 424922 59307 64014203
Mitral valve thickening 11.98 10.08 14 425208 387 64073123
Stem cell transplant 11.96 10.08 4 425218 3477 64070033
Dysarthria 11.95 10.08 299 424923 59107 64014403
Acute lymphocytic leukaemia 11.91 10.08 7 425215 4364 64069146
Complication of device removal 11.90 10.08 48 425174 3232 64070278
Meningitis 11.90 10.08 23 425199 8306 64065204
Pneumonectomy 11.88 10.08 7 425215 70 64073440
Infusion site swelling 11.87 10.08 69 425153 5396 64068114
Metastasis 11.86 10.08 12 425210 5683 64067827
Aortic dissection 11.80 10.08 4 425218 3448 64070062
Bronchoscopy 11.79 10.08 7 425215 71 64073439
Ear congestion 11.73 10.08 36 425186 2114 64071396
Ageusia 11.71 10.08 141 425081 13672 64059838
Macular oedema 11.65 10.08 9 425213 4858 64068652
Breast conserving surgery 11.64 10.08 17 425205 588 64072922
Nephrogenic systemic fibrosis 11.62 10.08 13 425209 5879 64067631
Trifascicular block 11.60 10.08 9 425213 146 64073364
Accidental death 11.60 10.08 5 425217 3720 64069790
Cyanosis 11.60 10.08 208 425014 21947 64051563
Deafness neurosensory 11.57 10.08 15 425207 6359 64067151
Grunting 11.57 10.08 14 425208 402 64073108
Bronchitis chronic 11.55 10.08 54 425168 3878 64069632
Cervicogenic headache 11.51 10.08 5 425217 24 64073486
Gastrointestinal haemorrhage 11.44 10.08 735 424487 131577 63941933
Tongue disorder 11.42 10.08 41 425181 12039 64061471
Staphylococcal sepsis 11.40 10.08 45 425177 12854 64060656
Infusion site mass 11.40 10.08 22 425200 959 64072551
CFTR gene mutation 11.39 10.08 7 425215 76 64073434
Erysipelas 11.37 10.08 27 425195 9054 64064456
Infusion site erythema 11.37 10.08 81 425141 6792 64066718
Blood immunoglobulin E abnormal 11.35 10.08 5 425217 25 64073485
Post-tussive vomiting 11.35 10.08 5 425217 25 64073485
Bradykinesia 11.34 10.08 16 425206 6544 64066966
Gastrointestinal toxicity 11.33 10.08 11 425211 5311 64068199
Tobacco abuse 11.29 10.08 20 425202 816 64072694
Product administration error 11.28 10.08 250 424972 27393 64046117
Drug use disorder 11.25 10.08 14 425208 6040 64067470
Delusion 11.24 10.08 71 425151 17943 64055567
Peak expiratory flow rate abnormal 11.24 10.08 7 425215 78 64073432
Lactose intolerance 11.23 10.08 34 425188 1982 64071528
Musculoskeletal discomfort 11.23 10.08 160 425062 16117 64057393
Hyperhidrosis 11.21 10.08 963 424259 123957 63949553
Weaning failure 11.19 10.08 17 425205 609 64072901
Meningitis cryptococcal 11.17 10.08 3 425219 3006 64070504
Device failure 11.17 10.08 70 425152 5622 64067888
Paraneoplastic rash 11.09 10.08 7 425215 80 64073430
Gastric cancer 11.06 10.08 16 425206 6477 64067033
Endometriosis 11.06 10.08 42 425180 2750 64070760
Feeling jittery 11.05 10.08 113 425109 10522 64062988
Herpes virus infection 11.02 10.08 15 425207 6229 64067281
Hypermetropia 11.01 10.08 14 425208 423 64073087
Blood culture positive 11.00 10.08 22 425200 7846 64065664
Paranasal sinus hypersecretion 10.99 10.08 45 425177 3051 64070459
Cutaneous vasculitis 10.98 10.08 16 425206 6457 64067053
Sexual dysfunction 10.97 10.08 16 425206 6455 64067055
Communication disorder 10.97 10.08 51 425171 3655 64069855
Hyperventilation 10.96 10.08 80 425142 6760 64066750
Thrombotic thrombocytopenic purpura 10.95 10.08 14 425208 5970 64067540
Orthopnoea 10.94 10.08 100 425122 9034 64064476
Hernia pain 10.94 10.08 14 425208 426 64073084
Melaena 10.91 10.08 269 424953 53279 64020231
Essential hypertension 10.90 10.08 65 425157 5129 64068381
Device expulsion 10.90 10.08 88 425134 21048 64052462
Vaccination site erythema 10.90 10.08 6 425216 52 64073458
Blebitis 10.90 10.08 4 425218 11 64073499
Otitis media 10.89 10.08 67 425155 5346 64068164
Renal artery stent placement 10.89 10.08 5 425217 28 64073482
Electrocardiogram QT shortened 10.84 10.08 10 425212 208 64073302
Adverse event 10.82 10.08 189 425033 39300 64034210
Intestinal perforation 10.81 10.08 58 425164 15255 64058255
Red cell distribution width abnormal 10.80 10.08 10 425212 209 64073301
Thoracic haemorrhage 10.80 10.08 10 425212 209 64073301
Nasal dryness 10.79 10.08 49 425173 3477 64070033
Pleural effusion 10.78 10.08 704 424518 125855 63947655
Lymphocyte count decreased 10.77 10.08 196 425026 40503 64033007
Lipohypertrophy 10.76 10.08 19 425203 773 64072737
Sputum culture positive 10.75 10.08 44 425178 2982 64070528
Monoparesis 10.75 10.08 3 425219 2931 64070579
Aortic aneurysm 10.69 10.08 86 425136 7488 64066022
Upper respiratory tract congestion 10.68 10.08 36 425186 2222 64071288
Neuromyotonia 10.66 10.08 7 425215 86 64073424
Gastrointestinal perforation 10.66 10.08 12 425210 5412 64068098
Pseudomembranous colitis 10.65 10.08 10 425212 4906 64068604
Acute coronary syndrome 10.61 10.08 79 425143 19231 64054279
Atypical fracture 10.60 10.08 17 425205 639 64072871
Nasal septal operation 10.59 10.08 7 425215 87 64073423
Retinal artery occlusion 10.58 10.08 3 425219 2900 64070610
Tobacco user 10.54 10.08 17 425205 642 64072868
Wrong technique in product usage process 10.53 10.08 337 424885 64637 64008873
School refusal 10.48 10.08 5 425217 31 64073479
Peripheral swelling 10.47 10.08 1552 423670 207601 63865909
Airway peak pressure increased 10.46 10.08 12 425210 325 64073185
Meralgia paraesthetica 10.45 10.08 11 425211 270 64073240
Cardiac tamponade 10.44 10.08 24 425198 8140 64065370
Product packaging quantity issue 10.43 10.08 21 425201 945 64072565
Thymus disorder 10.42 10.08 10 425212 219 64073291
Pneumonia cytomegaloviral 10.41 10.08 8 425214 4331 64069179
Generalised anxiety disorder 10.39 10.08 32 425190 1883 64071627
Dyskinesia oesophageal 10.35 10.08 6 425216 58 64073452
Radioallergosorbent test positive 10.35 10.08 5 425217 32 64073478
Hypervolaemia 10.34 10.08 328 424894 37957 64035553
Oesophagogastroduodenoscopy 10.34 10.08 9 425213 173 64073337
Quadriparesis 10.32 10.08 3 425219 2854 64070656
Grip strength decreased 10.30 10.08 41 425181 11683 64061827
Colon cancer 10.30 10.08 46 425176 12693 64060817
Pneumococcal sepsis 10.28 10.08 25 425197 1279 64072231
Prothrombin time shortened 10.28 10.08 3 425219 2846 64070664
Eye allergy 10.26 10.08 14 425208 454 64073056
Ovarian hyperstimulation syndrome 10.26 10.08 3 425219 2842 64070668
Hypothyroidism 10.26 10.08 344 424878 40113 64033397
Fungal disease carrier 10.25 10.08 11 425211 276 64073234
Postural orthostatic tachycardia syndrome 10.22 10.08 15 425207 521 64072989
Social avoidant behaviour 10.20 10.08 58 425164 4499 64069011
Caesarean section 10.18 10.08 39 425183 11235 64062275
Neoplasm recurrence 10.17 10.08 6 425216 3733 64069777
Hepatitis fulminant 10.17 10.08 16 425206 6258 64067252
Diffuse large B-cell lymphoma recurrent 10.16 10.08 4 425218 3142 64070368
Red blood cell count decreased 10.15 10.08 242 424980 48144 64025366
Guillain-Barre syndrome 10.13 10.08 22 425200 7613 64065897
Body mass index increased 10.12 10.08 28 425194 1551 64071959
Femoral neck fracture 10.10 10.08 27 425195 8697 64064813
PO2 decreased 10.08 10.08 40 425182 2673 64070837

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03AC02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
ATC R03AK04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AK13 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AL02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC R03CC02 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
FDA MoA N0000009922 Adrenergic beta2-Agonists
CHEBI has role CHEBI:35522 beta-adrenergic agonists
CHEBI has role CHEBI:35523 bronchodilator
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058666 Adrenergic beta-2 Receptor Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D012102 Reproductive Control Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D015149 Tocolytic Agents
FDA EPC N0000175779 beta2-Adrenergic Agonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Bronchospasm indication 4386001
Acute exacerbation of asthma indication 708038006
Bronchospasm Prevention indication
Exercise-Induced Bronchospasm Prevention indication
Chronic Obstructive Pulmonary Disease with Bronchospasms indication
Chronic obstructive lung disease off-label use 13645005 DOID:3083
Ocular hypertension contraindication 4210003 DOID:9282
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Ketoacidosis contraindication 56051008
Metabolic acidosis contraindication 59455009
Diabetes mellitus contraindication 73211009 DOID:9351
Paradoxical bronchospasm contraindication 102578005
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Myocardial ischemia contraindication 414795007 DOID:3393
Congenital long QT syndrome contraindication 442917000




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Horses Immediate relief of bronchospasm and bronchoconstriction associated with reversible airway obstruction Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Torpex Boehringer lngelheim Animal Health USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.07 acidic
pKa2 9.46 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST Ki 5.95 WOMBAT-PK CHEMBL
Beta-1 adrenergic receptor GPCR Ki 5.61 PDSP
Beta-2 adrenergic receptor GPCR Kd 5.94 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 6.28 CHEMBL

External reference:

IDSource
4018796 VUID
N0000147099 NUI
D02147 KEGG_DRUG
51022-70-9 SECONDARY_CAS_RN
142153 RXNORM
C0001927 UMLSCUI
CHEBI:2549 CHEBI
68H PDB_CHEM_ID
CHEMBL714 ChEMBL_ID
DB01001 DRUGBANK_ID
CHEMBL1441059 ChEMBL_ID
CHEMBL1201026 ChEMBL_ID
2083 PUBCHEM_CID
558 IUPHAR_LIGAND_ID
QF8SVZ843E UNII
3007 MMSL
30960 MMSL
4143 MMSL
4144 MMSL
46702 MMSL
d00749 MMSL
001814 NDDF
001815 NDDF
4018796 VANDF
4018797 VANDF
D000420 MESH_DESCRIPTOR_UI
2585 INN_ID
372897005 SNOMEDCT_US
48474002 SNOMEDCT_US
91143003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0742 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) ANDA 14 sections
Proventil HFA HUMAN PRESCRIPTION DRUG LABEL 1 0085-1132 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 22 sections
Proventil HFA HUMAN PRESCRIPTION DRUG LABEL 1 0085-1132 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 22 sections
Albuterol SulfateHFA HUMAN PRESCRIPTION DRUG LABEL 1 0093-3174 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 26 sections
VENTOLINHFA HUMAN PRESCRIPTION DRUG LABEL 1 0173-0682 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 25 sections
VENTOLINHFA HUMAN PRESCRIPTION DRUG LABEL 1 0173-0682 AEROSOL, METERED 90 ug RESPIRATORY (INHALATION) NDA 25 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0254-1007 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA authorized generic 24 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0255 TABLET 2 mg ORAL ANDA 23 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0572 TABLET 4 mg ORAL ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6991 SOLUTION 0.63 mg RESPIRATORY (INHALATION) NDA authorized generic 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-6992 SOLUTION 1.25 mg RESPIRATORY (INHALATION) NDA authorized generic 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-8270 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 24 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0378-9671 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 28 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0472-0825 SYRUP 2 mg ORAL ANDA 22 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0487-0201 SOLUTION 3 mg RESPIRATORY (INHALATION) ANDA 28 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-0301 SOLUTION 0.63 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9501 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9901 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0487-9904 SOLUTION 1.25 mg RESPIRATORY (INHALATION) ANDA 26 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3467 SOLUTION 0.63 mg INTRABRONCHIAL ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3468 SOLUTION 1.25 mg INTRABRONCHIAL ANDA 23 sections
Combivent Respimat HUMAN PRESCRIPTION DRUG LABEL 2 0597-0024 SPRAY, METERED 100 ug RESPIRATORY (INHALATION) NDA 27 sections
Ipratropium Bromide and Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 2 0781-7146 SOLUTION 3 mg RESPIRATORY (INHALATION) ANDA 28 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-7155 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 23 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-7296 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA authorized generic 24 sections
VENTOLINHFA HUMAN PRESCRIPTION DRUG LABEL 1 16590-339 AEROSOL, METERED 108 ug RESPIRATORY (INHALATION) NDA 27 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 17856-0740 SYRUP 2 mg ORAL ANDA 19 sections
Albuterol HUMAN PRESCRIPTION DRUG LABEL 1 21695-198 AEROSOL, METERED 90 ug ORAL ANDA 24 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 21695-245 SOLUTION 5 mg RESPIRATORY (INHALATION) ANDA 18 sections
Albuterol Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 21695-332 SOLUTION 2.50 mg RESPIRATORY (INHALATION) ANDA 23 sections