esmolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 1054 81147-92-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • esmolol
  • brevibloc
  • esmolol hydrochloride
  • esmolol HCl
a beta1-selective (cardioselective) adrenergic receptor blocking agent with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilizing activity at therapeutic dosages
  • Molecular weight: 295.38
  • Formula: C16H25NO4
  • CLOGP: 1.72
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 67.79
  • ALOGS: -3.31
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 20 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.68 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 290 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.59 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.15 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 31, 1986 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 84.87 69.19 72 523 1044693 62443734

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 78.62 42.83 75 817 456676 34499363
Bradycardia 57.56 42.83 31 861 75387 34880652
Cardiac arrest 53.13 42.83 32 860 96127 34859912
Pulseless electrical activity 46.94 42.83 14 878 7197 34948842
Hypotension 46.59 42.83 41 851 221608 34734431

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 129.43 42.88 125 1331 1080788 78662144
Cardiac arrest 83.96 42.88 47 1409 172049 79570883
Bradycardia 63.25 42.88 36 1420 135521 79607411
Neuromuscular block prolonged 52.82 42.88 10 1446 1020 79741912
Pulseless electrical activity 50.35 42.88 16 1440 14144 79728788
Hypotension 50.04 42.88 50 1406 440267 79302665

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AB09 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
FDA MoA N0000000161 Adrenergic beta-Antagonists
FDA EPC N0000175556 beta-Adrenergic Blocker
CHEBI has role CHEBI:35530 beta-adrenergic blockers
CHEBI has role CHEBI:38070 antiarrhythmic agent
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Supraventricular tachycardia indication 6456007
Atrial fibrillation indication 49436004 DOID:0060224
Perioperative hypertension indication 434711000124103
Perioperative Tachycardia indication
Malignant essential hypertension off-label use 78975002 DOID:10823
Dissection of aorta off-label use 308546005
Acute coronary syndrome off-label use 394659003
Hypertensive urgency off-label use 443482000
Prevention of Hypertension in Pheochromocytoma off-label use
Bronchospasm contraindication 4386001
Anaphylaxis contraindication 39579001
Sinus bradycardia contraindication 49710005
Diabetes mellitus contraindication 73211009 DOID:9351
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Kidney disease contraindication 90708001 DOID:557
Decompensated cardiac failure contraindication 195111005
Heart block contraindication 233916004
Acute exacerbation of asthma contraindication 708038006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 6.90 IUPHAR IUPHAR
Beta-2 adrenergic receptor GPCR Kd 5.20 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 7 CHEMBL

External reference:

IDSource
4019746 VUID
N0000147837 NUI
D00644 KEGG_DRUG
81161-17-3 SECONDARY_CAS_RN
4019349 VANDF
4019746 VANDF
C0116569 UMLSCUI
CHEBI:4856 CHEBI
CHEMBL768 ChEMBL_ID
CHEMBL1201115 ChEMBL_ID
DB00187 DRUGBANK_ID
C036604 MESH_SUPPLEMENTAL_RECORD_UI
59768 PUBCHEM_CID
7178 IUPHAR_LIGAND_ID
5365 INN_ID
MDY902UXSR UNII
151448 RXNORM
3762 MMSL
4681 MMSL
47065 MMSL
d00224 MMSL
001861 NDDF
004745 NDDF
35318005 SNOMEDCT_US
372847006 SNOMEDCT_US
77856005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Brevibloc HUMAN PRESCRIPTION DRUG LABEL 1 0404-9825 INJECTION 10 mg INTRAVENOUS NDA 25 sections
Brevibloc HUMAN PRESCRIPTION DRUG LABEL 1 0404-9825 INJECTION 10 mg INTRAVENOUS NDA 25 sections
Brevibloc HUMAN PRESCRIPTION DRUG LABEL 1 0404-9825 INJECTION 10 mg INTRAVENOUS NDA 25 sections
ESMOLOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9858 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 17 sections
ESMOLOL HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9858 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 17 sections
Esmolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0641-2965 INJECTION 10 mg INTRAVENOUS NDA 17 sections
Brevibloc HUMAN PRESCRIPTION DRUG LABEL 1 10019-055 INJECTION 10 mg INTRAVENOUS NDA 25 sections
Brevibloc HUMAN PRESCRIPTION DRUG LABEL 1 10019-055 INJECTION 10 mg INTRAVENOUS NDA 25 sections
Brevibloc HUMAN PRESCRIPTION DRUG LABEL 1 10019-055 INJECTION 10 mg INTRAVENOUS NDA 25 sections
Brevibloc HUMAN PRESCRIPTION DRUG LABEL 1 10019-075 INJECTION 20 mg INTRAVENOUS NDA 25 sections
Brevibloc HUMAN PRESCRIPTION DRUG LABEL 1 10019-075 INJECTION 20 mg INTRAVENOUS NDA 25 sections
Brevibloc HUMAN PRESCRIPTION DRUG LABEL 1 10019-075 INJECTION 20 mg INTRAVENOUS NDA 25 sections
Brevibloc HUMAN PRESCRIPTION DRUG LABEL 1 10019-115 INJECTION 10 mg INTRAVENOUS NDA 25 sections
Brevibloc HUMAN PRESCRIPTION DRUG LABEL 1 10019-115 INJECTION 10 mg INTRAVENOUS NDA 25 sections
Brevibloc HUMAN PRESCRIPTION DRUG LABEL 1 10019-115 INJECTION 10 mg INTRAVENOUS NDA 25 sections
Esmolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10019-120 INJECTION 10 mg INTRAVENOUS NDA 26 sections
Esmolol Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10019-120 INJECTION 10 mg INTRAVENOUS NDA 26 sections
BREVIBLOC HUMAN PRESCRIPTION DRUG LABEL 1 10019-666 INJECTION 20 mg INTRAVENOUS NDA 26 sections
BREVIBLOC HUMAN PRESCRIPTION DRUG LABEL 1 10019-666 INJECTION 20 mg INTRAVENOUS NDA 26 sections
BREVIBLOC HUMAN PRESCRIPTION DRUG LABEL 1 10019-666 INJECTION 20 mg INTRAVENOUS NDA 26 sections
BREVIBLOC HUMAN PRESCRIPTION DRUG LABEL 1 10019-668 INJECTION 20 mg INTRAVENOUS NDA 26 sections
BREVIBLOC HUMAN PRESCRIPTION DRUG LABEL 1 10019-668 INJECTION 20 mg INTRAVENOUS NDA 26 sections
BREVIBLOC HUMAN PRESCRIPTION DRUG LABEL 1 10019-668 INJECTION 20 mg INTRAVENOUS NDA 26 sections
BREVIBLOC HUMAN PRESCRIPTION DRUG LABEL 1 10019-670 INJECTION 10 mg INTRAVENOUS NDA 26 sections
BREVIBLOC HUMAN PRESCRIPTION DRUG LABEL 1 10019-670 INJECTION 10 mg INTRAVENOUS NDA 26 sections
BREVIBLOC HUMAN PRESCRIPTION DRUG LABEL 1 10019-670 INJECTION 10 mg INTRAVENOUS NDA 26 sections
BREVIBLOC HUMAN PRESCRIPTION DRUG LABEL 1 10019-672 INJECTION 10 mg INTRAVENOUS NDA 26 sections
BREVIBLOC HUMAN PRESCRIPTION DRUG LABEL 1 10019-672 INJECTION 10 mg INTRAVENOUS NDA 26 sections
BREVIBLOC HUMAN PRESCRIPTION DRUG LABEL 1 10019-672 INJECTION 10 mg INTRAVENOUS NDA 26 sections
esmolol hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 25021-308 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 26 sections