escitalopram ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1053 128196-01-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • escitalopram
  • (+)-(S)-Citalopram
  • (+)-Citalopram
  • (S)-Citalopram
  • S-(+)-Citalopram
  • seroplex
  • escitalopram oxalate
  • Molecular weight: 324.40
  • Formula: C20H21FN2O
  • CLOGP: 3.13
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 36.26
  • ALOGS: -4.74
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.88 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Aug. 14, 2002 FDA FOREST LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Suicide attempt 472.04 9.51 674 151096 51058 50402296
Suicidal ideation 463.91 9.51 693 151077 54692 50398662
Electrocardiogram QT prolonged 447.18 9.51 658 151112 51228 50402126
Intentional overdose 444.07 9.51 725 151045 61779 50391575
Serotonin syndrome 370.95 9.51 413 151357 24300 50429054
Pemphigus 338.81 9.51 4 151766 120162 50333192
Sopor 317.05 9.51 343 151427 19536 50433818
Anxiety 279.13 9.51 1163 150607 176443 50276911
Contraindicated product administered 277.04 9.51 55 151715 148903 50304451
Systemic lupus erythematosus 274.28 9.51 46 151724 140576 50312778
Synovitis 266.38 9.51 30 151740 123835 50329519
Completed suicide 256.43 9.51 924 150846 130965 50322389
Hand deformity 250.14 9.51 12 151758 100187 50353167
Drug interaction 246.30 9.51 1217 150553 198404 50254950
Overdose 242.03 9.51 753 151017 98974 50354380
Depression 238.89 9.51 1056 150714 164367 50288987
Somnolence 231.88 9.51 1000 150770 153985 50299369
Treatment failure 228.03 9.51 65 151705 137572 50315782
Arthropathy 224.84 9.51 96 151674 157810 50295544
Glossodynia 218.39 9.51 41 151729 115528 50337826
Joint swelling 211.24 9.51 255 151515 245031 50208323
Drug intolerance 201.44 9.51 216 151554 218888 50234466
Drug ineffective 182.07 9.51 1580 150190 817753 49635601
Swelling 174.82 9.51 207 151563 200665 50252689
Tremor 166.09 9.51 734 151036 114169 50339185
Intentional self-injury 163.87 9.51 268 151502 22844 50430510
Alopecia 159.67 9.51 308 151462 244739 50208615
Infusion related reaction 155.95 9.51 167 151603 169390 50283964
Product substitution issue 153.62 9.51 200 151570 13857 50439497
Wound 152.65 9.51 63 151707 105731 50347623
Hyponatraemia 146.46 9.51 624 151146 95515 50357839
Pericarditis 146.34 9.51 29 151741 78660 50374694
Rheumatoid arthritis 135.04 9.51 251 151519 202299 50251055
Rheumatoid factor positive 134.88 9.51 3 151767 49856 50403498
Coma 131.94 9.51 423 151347 56456 50396898
Agitation 127.47 9.51 401 151369 52983 50400371
Inappropriate antidiuretic hormone secretion 125.33 9.51 175 151595 12968 50440386
Duodenal ulcer perforation 122.39 9.51 3 151767 45608 50407746
Helicobacter infection 120.72 9.51 7 151763 49695 50403659
Akathisia 115.74 9.51 133 151637 8096 50445258
Abdominal discomfort 110.75 9.51 342 151428 231299 50222055
Lower respiratory tract infection 110.40 9.51 75 151695 95126 50358228
Therapeutic product effect decreased 103.21 9.51 155 151615 135895 50317459
Tardive dyskinesia 101.29 9.51 117 151653 7162 50446192
Peripheral swelling 99.89 9.51 302 151468 205634 50247720
Seizure 97.86 9.51 647 151123 117227 50336127
Arthralgia 97.29 9.51 845 150925 437857 50015497
Mania 96.21 9.51 140 151630 10776 50442578
Withdrawal syndrome 96.19 9.51 182 151588 17408 50435946
Hepatic enzyme increased 92.61 9.51 169 151601 137211 50316143
Rash 92.02 9.51 854 150916 436617 50016737
Fall 91.53 9.51 1461 150309 333471 50119883
Maternal exposure during pregnancy 90.51 9.51 217 151553 159561 50293793
Poisoning deliberate 88.68 9.51 114 151656 7798 50445556
Drug hypersensitivity 88.67 9.51 419 151351 250591 50202763
Folliculitis 88.17 9.51 8 151762 39217 50414137
Muscle injury 87.81 9.51 6 151764 37105 50416249
Hypersensitivity 86.46 9.51 342 151428 214819 50238535
Panic attack 86.46 9.51 184 151586 19158 50434196
Irritability 85.58 9.51 232 151538 28194 50425160
Torsade de pointes 82.21 9.51 136 151634 11699 50441655
Impaired healing 80.87 9.51 55 151715 69731 50383623
Discomfort 80.72 9.51 125 151645 108255 50345099
Muscle rigidity 79.38 9.51 121 151649 9708 50443646
Dyskinesia 77.57 9.51 221 151549 27640 50425714
Drug abuse 75.82 9.51 368 151402 59478 50393876
Sympathomimetic effect 75.07 9.51 20 151750 38 50453316
Infection 72.62 9.51 270 151500 172684 50280670
Stomatitis 72.53 9.51 120 151650 101224 50352130
Disturbance in attention 72.36 9.51 232 151538 30954 50422400
Crying 72.16 9.51 177 151593 20239 50433115
Loss of consciousness 69.90 9.51 544 151226 103809 50349545
Mental disorder 68.74 9.51 182 151588 21809 50431545
Insomnia 68.14 9.51 813 150957 174052 50279302
Mydriasis 67.05 9.51 117 151653 10510 50442844
Tonsillar ulcer 66.54 9.51 27 151743 264 50453090
Long QT syndrome 65.33 9.51 61 151709 2906 50450448
Psychotic disorder 64.64 9.51 177 151593 21635 50431719
C-reactive protein abnormal 64.35 9.51 5 151765 27804 50425550
Extrapyramidal disorder 63.39 9.51 121 151649 11649 50441705
Febrile neutropenia 63.28 9.51 123 151647 97544 50355810
Paranoia 62.80 9.51 112 151658 10236 50443118
Blister 62.19 9.51 100 151670 85318 50368036
Neuroleptic malignant syndrome 61.90 9.51 116 151654 11014 50442340
Restlessness 61.82 9.51 191 151579 24982 50428372
Stiff person syndrome 61.78 9.51 24 151746 207 50453147
Hyperhidrosis 60.33 9.51 467 151303 88959 50364395
Product use issue 59.74 9.51 238 151532 149237 50304117
Sepsis 58.78 9.51 203 151567 132722 50320632
Pain 58.67 9.51 1307 150463 577596 49875758
Death 58.07 9.51 660 151110 324719 50128635
Toxicity to various agents 57.56 9.51 926 150844 211573 50241781
Hallucination, auditory 57.42 9.51 110 151660 10618 50442736
Pregnancy 57.16 9.51 207 151563 29370 50423984
Galactorrhoea 55.46 9.51 62 151708 3661 50449693
Cholecystitis chronic 55.31 9.51 102 151668 9567 50443787
Dizziness 55.21 9.51 1394 150376 344975 50108379
Drug withdrawal syndrome neonatal 54.94 9.51 45 151725 1796 50451558
Emotional distress 54.89 9.51 200 151570 28463 50424891
Confusional state 54.45 9.51 821 150949 185107 50268247
Depressed mood 54.22 9.51 224 151546 33799 50419555
Off label use 53.64 9.51 1052 150718 473374 49979980
Apathy 52.78 9.51 87 151683 7461 50445893
Depressed level of consciousness 52.42 9.51 300 151470 51653 50401701
Lower respiratory tract infection viral 50.55 9.51 29 151741 638 50452716
Hypertonia 50.54 9.51 61 151709 3912 50449442
C-reactive protein increased 50.12 9.51 76 151694 66398 50386956
Hyperreflexia 48.57 9.51 68 151702 5050 50448304
Multiple sclerosis relapse 47.97 9.51 255 151515 42709 50410645
Suicidal behaviour 47.61 9.51 46 151724 2288 50451066
Oculogyric crisis 46.87 9.51 37 151733 1400 50451954
Amnesia 46.62 9.51 250 151520 42010 50411344
Electrocardiogram QRS complex prolonged 46.31 9.51 68 151702 5276 50448078
Miosis 45.84 9.51 74 151696 6236 50447118
Delusion 45.46 9.51 99 151671 10470 50442884
Mobility decreased 44.90 9.51 109 151661 79839 50373515
Feeling abnormal 44.76 9.51 574 151196 124918 50328436
Psychomotor hyperactivity 43.33 9.51 90 151680 9211 50444143
Bruxism 42.52 9.51 49 151721 2991 50450363
Hip arthroplasty 42.46 9.51 19 151751 30410 50422944
Pulmonary embolism 42.30 9.51 479 151291 101225 50352129
Foetal exposure during pregnancy 41.93 9.51 178 151592 27181 50426173
Hallucination 41.68 9.51 261 151509 46396 50406958
Congenital absence of vertebra 41.22 9.51 12 151758 36 50453318
Sinus bradycardia 41.09 9.51 109 151661 13074 50440280
Inflammation 41.07 9.51 67 151703 56845 50396509
Drug withdrawal syndrome 40.65 9.51 166 151604 24915 50428439
Irritable bowel syndrome 40.55 9.51 57 151713 51384 50401970
Aggression 40.14 9.51 147 151623 20969 50432385
Abnormal behaviour 40.06 9.51 140 151630 19518 50433836
Deep vein thrombosis 39.96 9.51 365 151405 72939 50380415
Lip ulceration 39.53 9.51 37 151733 1768 50451586
Pyrexia 39.37 9.51 855 150915 379348 50074006
Reversible airways obstruction 39.29 9.51 29 151741 991 50452363
Knee arthroplasty 39.24 9.51 30 151740 35816 50417538
Bronchial secretion retention 39.02 9.51 34 151736 1479 50451875
Ill-defined disorder 38.82 9.51 65 151705 54589 50398765
Memory impairment 38.72 9.51 386 151384 78974 50374380
Sinusitis 38.32 9.51 327 151443 170231 50283123
Hallucination, visual 38.13 9.51 123 151647 16459 50436895
Reversible cerebral vasoconstriction syndrome 38.12 9.51 39 151731 2080 50451274
Psychomotor retardation 37.91 9.51 49 151721 3369 50449985
Acute kidney injury 37.79 9.51 470 151300 227588 50225766
Nasopharyngitis 37.71 9.51 383 151387 192544 50260810
Anger 37.68 9.51 96 151674 11237 50442117
Red blood cell sedimentation rate abnormal 37.64 9.51 3 151767 16340 50437014
Neutropenia 37.26 9.51 275 151495 147690 50305664
Abnormal dreams 37.15 9.51 85 151685 9292 50444062
Pyramidal tract syndrome 37.07 9.51 19 151751 331 50453023
Vital capacity decreased 36.42 9.51 27 151743 929 50452425
Muscle twitching 35.97 9.51 115 151655 15316 50438038
Mucosal inflammation 35.25 9.51 41 151729 40101 50413253
Clonus 34.57 9.51 52 151718 4123 50449231
Adjustment disorder with mixed anxiety and depressed mood 34.34 9.51 12 151758 74 50453280
Anhedonia 34.11 9.51 83 151687 9441 50443913
Mental status changes 33.71 9.51 205 151565 36067 50417287
Cardiac arrest 33.00 9.51 390 151380 83261 50370093
Syncope 32.95 9.51 462 151308 102540 50350814
Pneumocystis jirovecii pneumonia 32.93 9.51 3 151767 14660 50438694
Multiple sclerosis 32.71 9.51 135 151635 20358 50432996
Hostility 32.42 9.51 33 151737 1749 50451605
Small for dates baby 32.42 9.51 46 151724 3459 50449895
Nightmare 32.29 9.51 114 151656 15972 50437382
Bundle branch block left 32.26 9.51 63 151707 6167 50447187
Osteoporosis 32.22 9.51 53 151717 44826 50408528
Arthritis 31.59 9.51 143 151627 86578 50366776
Slow speech 31.44 9.51 28 151742 1254 50452100
Alcoholism 31.31 9.51 31 151739 1589 50451765
Self-injurious ideation 31.30 9.51 36 151734 2193 50451161
Multiple organ dysfunction syndrome 31.22 9.51 65 151705 50272 50403082
Renal impairment 31.15 9.51 119 151651 75542 50377812
Pancytopenia 30.95 9.51 138 151632 83892 50369462
Subdural hygroma 30.81 9.51 15 151755 233 50453121
Tachycardia 30.52 9.51 444 151326 99319 50354035
Bradyphrenia 30.40 9.51 61 151709 6091 50447263
Disease progression 30.38 9.51 166 151604 95700 50357654
Libido increased 30.19 9.51 27 151743 1216 50452138
Activation syndrome 30.11 9.51 14 151756 195 50453159
Derealisation 30.03 9.51 25 151745 1021 50452333
Optic nerve injury 29.24 9.51 19 151751 526 50452828
Affective disorder 28.81 9.51 54 151716 5127 50448227
Generalised tonic-clonic seizure 28.58 9.51 155 151615 26155 50427199
Homicidal ideation 28.24 9.51 30 151740 1672 50451682
Respiratory arrest 28.14 9.51 170 151600 29839 50423515
Cerebral haematoma 28.03 9.51 41 151729 3170 50450184
Restless legs syndrome 28.00 9.51 108 151662 15789 50437565
Dystonia 27.91 9.51 89 151681 11837 50441517
Congenital pulmonary valve atresia 27.79 9.51 10 151760 68 50453286
Gestational diabetes 27.75 9.51 66 151704 7399 50445955
Dyspnoea 27.41 9.51 1353 150417 546255 49907099
Sputum culture positive 27.22 9.51 27 151743 1387 50451967
Cytomegalovirus infection 27.04 9.51 10 151760 17952 50435402
Skin ulcer 26.98 9.51 40 151730 35278 50418076
Nausea 26.87 9.51 2459 149311 702939 49750415
Sight disability 26.80 9.51 11 151759 111 50453243
Thermohypoaesthesia 26.72 9.51 11 151759 112 50453242
Treatment noncompliance 26.51 9.51 168 151602 29982 50423372
Disorientation 26.00 9.51 189 151581 35295 50418059
Screaming 25.96 9.51 38 151732 2940 50450414
Gun shot wound 25.66 9.51 10 151760 87 50453267
Platelet aggregation inhibition 25.65 9.51 11 151759 125 50453229
Bone marrow failure 25.59 9.51 27 151743 27597 50425757
Morose 25.53 9.51 8 151762 33 50453321
Angle closure glaucoma 25.50 9.51 31 151739 2003 50451351
Obsessive-compulsive disorder 25.40 9.51 40 151730 3300 50450054
Depressive symptom 25.28 9.51 39 151731 3161 50450193
Head injury 25.08 9.51 140 151630 23880 50429474
Gastroschisis 24.89 9.51 13 151757 236 50453118
Tongue biting 24.88 9.51 25 151745 1305 50452049
Behaviour disorder 24.67 9.51 33 151737 2347 50451007
Initial insomnia 24.42 9.51 50 151720 5065 50448289
Musculoskeletal stiffness 24.29 9.51 257 151513 128224 50325130
Euphoric mood 23.47 9.51 43 151727 4012 50449342
Moaning 23.27 9.51 19 151751 755 50452599
Bipolar disorder 23.26 9.51 58 151712 6699 50446655
Sepsis neonatal 23.10 9.51 15 151755 415 50452939
Rheumatoid nodule 23.03 9.51 5 151765 12730 50440624
Hypersomnia 22.97 9.51 99 151671 15215 50438139
Conversion disorder 22.79 9.51 26 151744 1570 50451784
Ventricular dyskinesia 22.69 9.51 10 151760 122 50453232
Dysarthria 22.32 9.51 190 151580 37213 50416141
Large intestine anastomosis 22.31 9.51 7 151763 29 50453325
Bradypnoea 22.26 9.51 36 151734 3038 50450316
Mental impairment 22.18 9.51 83 151687 11961 50441393
Hepatic function abnormal 22.18 9.51 40 151730 32641 50420713
Drug screen positive 22.17 9.51 38 151732 3364 50449990
Adverse drug reaction 21.99 9.51 88 151682 55134 50398220
Nervousness 21.84 9.51 150 151620 27501 50425853
Immobilisation prolonged 21.49 9.51 9 151761 96 50453258
Negative thoughts 21.41 9.51 19 151751 847 50452507
Hyperthermia 21.37 9.51 61 151709 7635 50445719
Sinus tachycardia 21.33 9.51 123 151647 21231 50432123
Myoclonus 21.29 9.51 93 151677 14377 50438977
Pruritus 21.25 9.51 668 151102 282900 50170454
Extradural haematoma 21.23 9.51 25 151745 1562 50451792
Paraesthesia 21.21 9.51 491 151279 119752 50333602
Maternal drugs affecting foetus 21.20 9.51 47 151723 5030 50448324
Head banging 21.13 9.51 14 151756 401 50452953
Neutropenic sepsis 21.09 9.51 8 151762 14139 50439215
Somnambulism 21.04 9.51 46 151724 4878 50448476
Intermenstrual bleeding 20.89 9.51 56 151714 6758 50446596
Osteoarthritis 20.54 9.51 121 151649 68485 50384869
Disseminated intravascular coagulation 20.53 9.51 13 151757 17122 50436232
Emotional disorder 20.51 9.51 80 151690 11756 50441598
Antiphospholipid antibodies 20.50 9.51 10 151760 156 50453198
Pneumonia 20.46 9.51 927 150843 377474 50075880
Sexual dysfunction 20.45 9.51 36 151734 3256 50450098
Blood creatinine increased 20.40 9.51 139 151631 76021 50377333
Bradycardia 20.20 9.51 288 151482 64138 50389216
Pain in extremity 20.15 9.51 644 151126 272221 50181133
Epilepsy 20.11 9.51 122 151648 21445 50431909
Platelet count decreased 20.06 9.51 199 151571 100527 50352827
Postictal state 19.90 9.51 19 151751 931 50452423
Neutrophil count decreased 19.85 9.51 71 151699 45955 50407399
Dysphoria 19.72 9.51 44 151726 4730 50448624
Partner stress 19.55 9.51 12 151758 300 50453054
Cytotoxic oedema 19.51 9.51 9 151761 123 50453231
Bundle branch block right 19.40 9.51 43 151727 4602 50448752
Thinking abnormal 19.37 9.51 68 151702 9499 50443855
Polydipsia 19.20 9.51 34 151736 3090 50450264
Hypervigilance 19.14 9.51 12 151758 312 50453042
Retinal ischaemia 19.10 9.51 12 151758 313 50453041
Cardiogenic shock 19.09 9.51 95 151675 15504 50437850
Post-traumatic neck syndrome 19.06 9.51 26 151744 1884 50451470
Tracheal atresia 18.91 9.51 6 151764 26 50453328
Parkinsonism 18.89 9.51 64 151706 8783 50444571
Libido decreased 18.83 9.51 29 151741 2347 50451007
Bipolar I disorder 18.81 9.51 23 151747 1495 50451859
Band sensation 18.80 9.51 16 151754 674 50452680
Hypertensive cardiomyopathy 18.74 9.51 10 151760 190 50453164
Ocular hypertension 18.69 9.51 17 151753 783 50452571
Foot deformity 18.68 9.51 18 151752 19192 50434162
Rhabdomyolysis 18.63 9.51 189 151581 38838 50414516
Major depression 18.57 9.51 54 151716 6830 50446524
Drowning 18.52 9.51 13 151757 410 50452944
Hepatitis chronic active 18.48 9.51 7 151763 56 50453298
Hyperdynamic left ventricle 18.36 9.51 9 151761 142 50453212
Blood lactic acid 18.34 9.51 8 151762 95 50453259
Cardiac failure 18.33 9.51 143 151627 75897 50377457
Retroplacental haematoma 18.25 9.51 9 151761 144 50453210
Gastrointestinal disorder 18.23 9.51 188 151582 94268 50359086
Learning disorder 18.22 9.51 15 151755 603 50452751
Feeling jittery 18.19 9.51 74 151696 11086 50442268
Hyperventilation 18.17 9.51 46 151724 5363 50447991
Cardio-respiratory arrest 18.15 9.51 244 151526 53648 50399706
Blood prolactin increased 18.11 9.51 33 151737 3066 50450288
Fear 18.08 9.51 89 151681 14460 50438894
Road traffic accident 18.00 9.51 130 151640 24222 50429132
Acute myocardial infarction 17.98 9.51 38 151732 29235 50424119
Product administered to patient of inappropriate age 17.97 9.51 30 151740 2600 50450754
Feeling of despair 17.95 9.51 26 151744 1992 50451362
Amaurosis 17.82 9.51 14 151756 526 50452828
Psychomotor skills impaired 17.51 9.51 26 151744 2038 50451316
Unresponsive to stimuli 17.48 9.51 154 151616 30455 50422899
Biliary dyskinesia 17.30 9.51 29 151741 2521 50450833
Rectal ulcer 17.24 9.51 19 151751 1104 50452250
Injury 17.09 9.51 223 151547 48702 50404652
Hyperphagia 17.05 9.51 22 151748 1510 50451844
Bradykinesia 17.03 9.51 37 151733 3906 50449448
Psoriasis 16.91 9.51 296 151474 68704 50384650
Caesarean section 16.89 9.51 92 151678 15547 50437807
Left ventricle outflow tract obstruction 16.88 9.51 10 151760 234 50453120
Poisoning 16.87 9.51 78 151692 12351 50441003
Bone erosion 16.78 9.51 7 151763 11680 50441674
Vertigo 16.77 9.51 233 151537 51599 50401755
Anaemia 16.73 9.51 604 151166 251852 50201502
Product substitution error 16.71 9.51 5 151765 17 50453337
Cerebral thrombosis 16.65 9.51 22 151748 1546 50451808
Intentional product use issue 16.58 9.51 149 151621 76769 50376585
Barotrauma 16.54 9.51 9 151761 178 50453176
Decreased interest 16.53 9.51 31 151739 2945 50450409
Therapeutic product effect incomplete 16.51 9.51 185 151585 91330 50362024
Heavy menstrual bleeding 16.51 9.51 91 151679 15446 50437908
Colitis microscopic 16.50 9.51 50 151720 6470 50446884
Trunk injury 16.49 9.51 5 151765 18 50453336
Malignant neoplasm progression 16.48 9.51 128 151642 67996 50385358
Sedation 16.46 9.51 152 151618 30458 50422896
Tearfulness 16.39 9.51 35 151735 3652 50449702
Sleep disorder 16.36 9.51 252 151518 57031 50396323
Middle insomnia 16.34 9.51 66 151704 9855 50443499
Impulsive behaviour 16.33 9.51 21 151749 1437 50451917
Balance disorder 16.31 9.51 300 151470 70290 50383064
Oral candidiasis 16.27 9.51 16 151754 16899 50436455
Orgasm abnormal 16.13 9.51 7 151763 82 50453272
Victim of sexual abuse 16.11 9.51 13 151757 508 50452846
Panniculitis 16.08 9.51 3 151767 8500 50444854
Uterine perforation 16.05 9.51 49 151721 6366 50446988
Drug resistance 16.03 9.51 20 151750 18969 50434385
Breast swelling 16.02 9.51 18 151752 1069 50452285
Femur fracture 16.02 9.51 58 151712 37406 50415948
Persecutory delusion 16.00 9.51 27 151743 2360 50450994
Cogwheel rigidity 15.96 9.51 23 151747 1754 50451600
Magnetic resonance imaging head abnormal 15.96 9.51 23 151747 1754 50451600
Hepatitis infectious mononucleosis 15.91 9.51 7 151763 85 50453269
Dermatitis atopic 15.89 9.51 34 151736 3552 50449802
Red blood cell sedimentation rate increased 15.81 9.51 41 151729 29375 50423979
Interstitial lung disease 15.80 9.51 94 151676 53082 50400272
Ventricular fibrillation 15.64 9.51 68 151702 10491 50442863
Respiratory disorder 15.62 9.51 45 151725 31142 50422212
Exercise lack of 15.56 9.51 11 151759 351 50453003
Osteonecrosis of jaw 15.52 9.51 48 151722 32478 50420876
Septic shock 15.49 9.51 104 151666 57071 50396283
Hemianopia 15.44 9.51 16 151754 866 50452488
Self-medication 15.41 9.51 26 151744 2273 50451081
Concussion 15.26 9.51 54 151716 7574 50445780
Dry mouth 15.24 9.51 245 151525 55933 50397421
Gallbladder disorder 15.16 9.51 94 151676 16648 50436706
Orthostatic hypotension 15.16 9.51 145 151625 29336 50424018
Transplant rejection 15.06 9.51 5 151765 9604 50443750
Musculoskeletal pain 15.04 9.51 141 151629 72036 50381318
Congenital diaphragmatic eventration 14.88 9.51 4 151766 8 50453346
Anti-actin antibody positive 14.88 9.51 4 151766 8 50453346
Panic reaction 14.86 9.51 33 151737 3536 50449818
Hypokalaemia 14.80 9.51 357 151413 87635 50365719
Alcohol abuse 14.78 9.51 23 151747 1878 50451476
Tinnitus 14.78 9.51 139 151631 27993 50425361
Hypertension 14.75 9.51 502 151268 210701 50242653
Fibromyalgia 14.73 9.51 77 151693 44901 50408453
Hypocoagulable state 14.65 9.51 16 151754 920 50452434
Carcinoid syndrome 14.59 9.51 7 151763 105 50453249
Transposition of the great vessels 14.54 9.51 8 151762 162 50453192
Prothrombin level increased 14.52 9.51 9 151761 229 50453125
Soft tissue injury 14.51 9.51 20 151750 1464 50451890
Neuromyelitis optica spectrum disorder 14.49 9.51 15 151755 811 50452543
Psychiatric symptom 14.46 9.51 38 151732 4532 50448822
Cellulitis 14.46 9.51 139 151631 70659 50382695
Weight increased 14.41 9.51 742 151028 201149 50252205
Right ventricular dilatation 14.38 9.51 16 151754 940 50452414
Drug dependence 14.33 9.51 105 151665 19654 50433700
Obsessive thoughts 14.27 9.51 12 151758 497 50452857
Bursitis 14.22 9.51 28 151742 22107 50431247
Dissociation 14.16 9.51 25 151745 2266 50451088
Haemoglobin urine 14.14 9.51 7 151763 113 50453241
Alcohol use 13.96 9.51 23 151747 1972 50451382
Cardiac hypertrophy 13.93 9.51 16 151754 973 50452381
Fracture 13.92 9.51 18 151752 16815 50436539
Pupil fixed 13.81 9.51 20 151750 1532 50451822
Flight of ideas 13.80 9.51 10 151760 332 50453022
Stoma site discharge 13.71 9.51 18 151752 1257 50452097
Spinal cord oedema 13.71 9.51 7 151763 121 50453233
Attention-seeking behaviour 13.56 9.51 6 151764 74 50453280
Extensor plantar response 13.52 9.51 17 151753 1137 50452217
Torticollis 13.49 9.51 21 151749 1715 50451639
Wheezing 13.45 9.51 120 151650 61927 50391427
Myocardial infarction 13.42 9.51 187 151583 88840 50364514
Focal dyscognitive seizures 13.39 9.51 27 151743 2705 50450649
White blood cell count decreased 13.36 9.51 258 151512 116464 50336890
Brain injury 13.28 9.51 44 151726 5970 50447384
Dextrocardia 13.28 9.51 4 151766 14 50453340
Vision blurred 13.20 9.51 319 151451 78328 50375026
Lethargy 13.19 9.51 215 151555 49217 50404137
Staring 13.13 9.51 19 151751 1455 50451899
Cerebellar syndrome 13.10 9.51 30 151740 3281 50450073
Atrioventricular block 13.08 9.51 46 151724 6432 50446922
Pulmonary contusion 13.06 9.51 4 151766 15 50453339
Cough 13.02 9.51 591 151179 240673 50212681
Colour blindness 12.99 9.51 9 151761 278 50453076
Disinhibition 12.95 9.51 14 151756 796 50452558
Bundle branch block 12.92 9.51 14 151756 798 50452556
Mood swings 12.87 9.51 87 151683 15867 50437487
Apnoea 12.82 9.51 48 151722 6918 50446436
Joint hyperextension 12.76 9.51 9 151761 286 50453068
Substance abuse 12.75 9.51 34 151736 4090 50449264
Superior sagittal sinus thrombosis 12.69 9.51 13 151757 694 50452660
Tonsillitis 12.69 9.51 38 151732 4885 50448469
Haemophagocytic lymphohistiocytosis 12.67 9.51 5 151765 8628 50444726
Snoring 12.67 9.51 30 151740 3354 50450000
Ovarian vein thrombosis 12.59 9.51 5 151765 46 50453308
Narrow anterior chamber angle 12.59 9.51 5 151765 46 50453308
Haematotoxicity 12.57 9.51 4 151766 7891 50445463
Suspected suicide 12.56 9.51 40 151730 5317 50448037
Nuchal rigidity 12.42 9.51 12 151758 597 50452757
Anterograde amnesia 12.38 9.51 11 151759 491 50452863
Cerebral arteriovenous malformation haemorrhagic 12.37 9.51 3 151767 3 50453351
Wrong product procured 12.37 9.51 3 151767 3 50453351
Metamyelocyte count increased 12.27 9.51 8 151762 223 50453131
Mucosal ulceration 12.26 9.51 14 151756 846 50452508
Bile acid malabsorption 12.24 9.51 7 151763 153 50453201
Haemorrhagic stroke 12.22 9.51 39 151731 5189 50448165
Immunodeficiency 12.12 9.51 16 151754 14812 50438542
Multimorbidity 11.89 9.51 11 151759 518 50452836
Cor pulmonale acute 11.86 9.51 9 151761 321 50453033
Social avoidant behaviour 11.80 9.51 26 151744 2771 50450583
Sleep-related eating disorder 11.80 9.51 13 151757 755 50452599
Holoprosencephaly 11.68 9.51 4 151766 23 50453331
Creatinine urine decreased 11.66 9.51 7 151763 168 50453186
Migraine 11.64 9.51 302 151468 74978 50378376
Impaired driving ability 11.59 9.51 32 151738 3929 50449425
Gambling disorder 11.53 9.51 16 151754 1178 50452176
Coma scale abnormal 11.53 9.51 36 151734 4735 50448619
Retching 11.51 9.51 72 151698 12790 50440564
Convulsive threshold lowered 11.50 9.51 9 151761 336 50453018
Laryngectomy 11.40 9.51 4 151766 25 50453329
Metastases to bone 11.36 9.51 23 151747 17972 50435382
Choroidal effusion 11.30 9.51 10 151760 444 50452910
Sternal fracture 11.30 9.51 21 151749 1981 50451373
Enterococcus test positive 11.30 9.51 15 151755 1059 50452295
Neonatal respiratory depression 11.27 9.51 5 151765 62 50453292
Lung diffusion disorder 11.27 9.51 5 151765 62 50453292
Poor quality sleep 11.25 9.51 87 151683 16559 50436795
Xerophthalmia 11.17 9.51 9 151761 351 50453003
Wound healing normal 11.16 9.51 3 151767 6 50453348
Meningocele 11.16 9.51 3 151767 6 50453348
Atrophy of globe 11.16 9.51 3 151767 6 50453348
Tonic clonic movements 11.10 9.51 16 151754 1221 50452133
Antipsychotic drug level increased 11.03 9.51 27 151743 3082 50450272
Tachyphrenia 11.02 9.51 16 151754 1229 50452125
Head titubation 10.98 9.51 12 151758 691 50452663
Blood pressure diastolic decreased 10.98 9.51 21 151749 16760 50436594
Sialoadenitis 10.97 9.51 17 151753 1383 50451971
Pulseless electrical activity 10.86 9.51 45 151725 6796 50446558
Aphasia 10.86 9.51 132 151638 28362 50424992
Post concussion syndrome 10.84 9.51 10 151760 469 50452885
Enthesopathy 10.83 9.51 4 151766 7189 50446165
Optic atrophy 10.79 9.51 15 151755 1107 50452247
General physical health deterioration 10.78 9.51 335 151435 142099 50311255
Compulsive shopping 10.77 9.51 12 151758 706 50452648
Menometrorrhagia 10.74 9.51 13 151757 836 50452518
Periorbital haemorrhage 10.67 9.51 5 151765 71 50453283
CSF pressure increased 10.66 9.51 6 151764 127 50453227
Acute myeloid leukaemia 10.63 9.51 18 151752 15056 50438298
Blood cholesterol increased 10.61 9.51 110 151660 55105 50398249
Mitochondrial myopathy 10.61 9.51 5 151765 72 50453282
Ejection fraction decreased 10.59 9.51 25 151745 18495 50434859
Creatinine renal clearance decreased 10.57 9.51 12 151758 11869 50441485
Exposure via breast milk 10.53 9.51 18 151752 1590 50451764
Electrocardiogram P wave abnormal 10.49 9.51 7 151763 203 50453151
Flat affect 10.44 9.51 16 151754 1289 50452065
Compulsions 10.43 9.51 7 151763 205 50453149
Upper-airway cough syndrome 10.41 9.51 52 151718 8498 50444856
Sluggishness 10.39 9.51 33 151737 4380 50448974
Hypernatraemia 10.37 9.51 42 151728 6279 50447075
Live birth 10.33 9.51 21 151749 16387 50436967
Macular degeneration 10.32 9.51 17 151753 14371 50438983
Incoherent 10.29 9.51 32 151738 4198 50449156
Feeling hot 10.27 9.51 170 151600 39032 50414322
Logorrhoea 10.26 9.51 22 151748 2302 50451052
Pancreatic carcinoma recurrent 10.25 9.51 5 151765 78 50453276
Essential tremor 10.24 9.51 13 151757 878 50452476
Apallic syndrome 10.22 9.51 11 151759 622 50452732
Haematoma 10.21 9.51 138 151632 30372 50422982
Biliary colic 10.21 9.51 27 151743 3232 50450122
Neonatal asphyxia 10.19 9.51 7 151763 213 50453141
Therapeutic response unexpected 10.11 9.51 82 151688 15833 50437521
Immune-mediated myositis 10.09 9.51 14 151756 1031 50452323
Disturbance in sexual arousal 10.08 9.51 5 151765 81 50453273
Neoplasm progression 10.07 9.51 49 151721 29108 50424246
Congenital tracheomalacia 10.05 9.51 4 151766 37 50453317
Diplopia 10.03 9.51 95 151675 19165 50434189
Oesophageal atresia 10.03 9.51 10 151760 517 50452837
Housebound 10.02 9.51 7 151763 219 50453135
Tubulointerstitial nephritis 9.98 9.51 19 151751 15192 50438162
Multiple allergies 9.97 9.51 51 151719 8412 50444942
Endometrial disorder 9.93 9.51 11 151759 643 50452711
Amenorrhoea 9.91 9.51 51 151719 8433 50444921
Cluster headache 9.90 9.51 10 151760 525 50452829
Tic 9.85 9.51 15 151755 1202 50452152
Belligerence 9.85 9.51 6 151764 148 50453206
Psychotic disorder due to a general medical condition 9.80 9.51 7 151763 227 50453127
Micturition disorder 9.79 9.51 19 151751 1852 50451502
Catatonia 9.78 9.51 29 151741 3707 50449647
Yawning 9.77 9.51 13 151757 920 50452434
Erythema 9.75 9.51 350 151420 146064 50307290
Sleep talking 9.73 9.51 13 151757 923 50452431
Electrocardiogram U wave present 9.71 9.51 5 151765 88 50453266
Splenic thrombosis 9.65 9.51 3 151767 12 50453342
Skin necrosis 9.65 9.51 11 151759 10856 50442498
Blood osmolarity increased 9.64 9.51 6 151764 154 50453200
Inappropriate affect 9.63 9.51 12 151758 795 50452559
Speech disorder 9.63 9.51 155 151615 35393 50417961
Basilar migraine 9.61 9.51 4 151766 42 50453312
Anorgasmia 9.60 9.51 10 151760 545 50452809
Osteonecrosis 9.53 9.51 35 151735 22482 50430872
Device placement issue 9.53 9.51 12 151758 804 50452550
Polyarthritis 9.51 9.51 6 151764 7921 50445433

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 423.62 10.02 340 68270 17172 29488745
Completed suicide 293.76 10.02 647 67963 89599 29416318
Suicidal ideation 284.54 10.02 376 68234 34340 29471577
Suicide attempt 247.08 10.02 348 68262 33762 29472155
Intentional overdose 227.29 10.02 357 68253 38171 29467746
Agitation 172.56 10.02 373 68237 50931 29454986
Anxiety 151.67 10.02 489 68121 84876 29421041
Aggression 132.99 10.02 270 68340 35271 29470646
Somnolence 128.71 10.02 494 68116 93461 29412456
Foetal exposure during pregnancy 124.01 10.02 255 68355 33612 29472305
Depression 115.21 10.02 446 68164 84701 29421216
Tremor 114.42 10.02 403 68207 73135 29432782
Sopor 106.25 10.02 129 68481 10805 29495112
Intentional self-injury 100.51 10.02 134 68476 12327 29493590
Overdose 90.51 10.02 396 68214 79423 29426494
Electrocardiogram QT prolonged 90.20 10.02 234 68376 35903 29470014
Paranoia 88.69 10.02 112 68498 9765 29496152
Poisoning deliberate 87.89 10.02 86 68524 5645 29500272
Mania 87.10 10.02 104 68506 8559 29497358
Sexual dysfunction 79.53 10.02 82 68528 5732 29500185
Withdrawal syndrome 79.29 10.02 112 68498 10880 29495037
Drug interaction 75.62 10.02 744 67866 196641 29309276
Febrile neutropenia 69.80 10.02 95 68515 112145 29393772
Intrusive thoughts 69.19 10.02 25 68585 230 29505687
Restlessness 66.52 10.02 154 68456 21991 29483926
Maternal drugs affecting foetus 66.49 10.02 62 68548 3831 29502086
Drug withdrawal syndrome 65.31 10.02 135 68475 17849 29488068
Muscle rigidity 65.10 10.02 94 68516 9317 29496600
Insomnia 63.34 10.02 387 68223 88374 29417543
Disturbance in attention 63.27 10.02 148 68462 21276 29484641
Fall 62.62 10.02 657 67953 176521 29329396
Coma 61.12 10.02 216 68394 39234 29466683
Dyskinesia 60.79 10.02 140 68470 19921 29485996
Confusional state 60.62 10.02 505 68105 127372 29378545
Irritability 57.90 10.02 146 68464 22006 29483911
Activation syndrome 56.41 10.02 17 68593 82 29505835
Major depression 55.93 10.02 56 68554 3779 29502138
Erectile dysfunction 54.92 10.02 126 68484 17883 29488034
Loss of libido 54.24 10.02 44 68566 2252 29503665
Apathy 53.86 10.02 69 68541 6102 29499815
Anger 53.50 10.02 93 68517 10797 29495120
Interstitial lung disease 53.37 10.02 34 68576 57684 29448233
Panic attack 53.03 10.02 80 68530 8246 29497671
Hyperhidrosis 52.91 10.02 292 68318 64248 29441669
Thrombocytopenia 52.74 10.02 150 68460 134673 29371244
Sedation 52.22 10.02 121 68489 17284 29488633
Product substitution issue 51.28 10.02 83 68527 9089 29496828
Libido decreased 50.62 10.02 56 68554 4242 29501675
Pyrexia 50.07 10.02 427 68183 287195 29218722
Neutropenia 49.73 10.02 149 68461 131562 29374355
Septic shock 48.70 10.02 44 68566 62516 29443401
Pneumonia 48.57 10.02 492 68118 319680 29186237
Hypomania 47.87 10.02 40 68570 2135 29503782
Akathisia 47.60 10.02 68 68542 6674 29499243
Renal impairment 47.42 10.02 72 68538 81261 29424656
Anorgasmia 45.47 10.02 24 68586 583 29505334
Gun shot wound 44.40 10.02 29 68581 1056 29504861
Hallucination 44.07 10.02 213 68397 44499 29461418
Parkinsonism 43.64 10.02 68 68542 7210 29498707
Hallucination, visual 43.54 10.02 103 68507 14912 29491005
Mycotic allergy 43.47 10.02 18 68592 246 29505671
Abulia 43.45 10.02 22 68588 489 29505428
Tardive dyskinesia 43.09 10.02 57 68553 5201 29500716
Tachyphrenia 42.44 10.02 29 68581 1140 29504777
Respiratory disorder neonatal 41.70 10.02 31 68579 1394 29504523
Chest injury 41.54 10.02 31 68579 1402 29504515
Sepsis 40.91 10.02 181 68429 142501 29363416
Homicidal ideation 40.82 10.02 39 68571 2485 29503432
Bipolar disorder 40.67 10.02 44 68566 3251 29502666
Mite allergy 40.30 10.02 18 68592 299 29505618
Renal failure 40.01 10.02 141 68469 118458 29387459
Mood swings 39.70 10.02 65 68545 7186 29498731
Neuroleptic malignant syndrome 39.69 10.02 104 68506 16044 29489873
Mydriasis 39.51 10.02 59 68551 6026 29499891
Malignant neoplasm progression 38.76 10.02 70 68540 73789 29432128
Acute kidney injury 38.39 10.02 412 68198 264855 29241062
Spirometry abnormal 37.32 10.02 18 68592 359 29505558
Sleep disorder 37.31 10.02 133 68477 24253 29481664
Alcoholism 37.24 10.02 38 68572 2623 29503294
Hallucination, auditory 37.19 10.02 74 68536 9519 29496398
Drug withdrawal syndrome neonatal 36.19 10.02 42 68568 3353 29502564
Memory impairment 36.13 10.02 174 68436 36296 29469621
Anaemia 35.95 10.02 296 68314 200655 29305262
Multiple organ dysfunction syndrome 35.71 10.02 57 68553 63059 29442858
Foetal malformation 35.47 10.02 13 68597 125 29505792
Abnormal behaviour 35.26 10.02 126 68484 23001 29482916
Infusion related reaction 35.19 10.02 30 68580 43856 29462061
Amnesia 35.07 10.02 124 68486 22519 29483398
Seizure 34.56 10.02 349 68261 92774 29413143
Trisomy 18 34.44 10.02 14 68596 182 29505735
Hyperreflexia 34.18 10.02 37 68573 2735 29503182
Resting tremor 34.18 10.02 20 68590 597 29505320
Social avoidant behaviour 34.08 10.02 38 68572 2904 29503013
Homicide 33.64 10.02 23 68587 905 29505012
Bone marrow failure 33.38 10.02 11 68599 27438 29478479
Impulsive behaviour 33.29 10.02 31 68579 1912 29504005
Conjunctivitis allergic 33.21 10.02 20 68590 630 29505287
Dust allergy 32.89 10.02 18 68592 471 29505446
Small for dates baby 32.79 10.02 41 68569 3538 29502379
Walking aid user 32.17 10.02 27 68583 1450 29504467
Electrocardiogram QT interval 31.83 10.02 9 68601 33 29505884
Anencephaly 31.72 10.02 12 68598 127 29505790
Loss of consciousness 31.66 10.02 286 68324 73770 29432147
Painful respiration 30.95 10.02 24 68586 1150 29504767
Skin dystrophy 30.64 10.02 7 68603 7 29505910
Dyspnoea 30.61 10.02 554 68056 326178 29179739
Delusion 30.43 10.02 75 68535 11141 29494776
Postural orthostatic tachycardia syndrome 30.28 10.02 9 68601 41 29505876
Psychotic disorder 30.27 10.02 110 68500 20244 29485673
Prescribed overdose 30.14 10.02 64 68546 8619 29497298
Electrocardiogram QRS complex prolonged 29.82 10.02 42 68568 4068 29501849
Rheumatoid arthritis 29.63 10.02 19 68591 32133 29473784
Depressed mood 28.93 10.02 94 68516 16354 29489563
Cerebral haematoma 28.39 10.02 42 68568 4254 29501663
Delirium 28.20 10.02 172 68438 39225 29466692
Craniosynostosis 28.16 10.02 14 68596 299 29505618
Blood creatinine increased 28.13 10.02 102 68508 85000 29420917
Clonus 28.03 10.02 31 68579 2347 29503570
Feeling abnormal 27.90 10.02 219 68391 54226 29451691
Drug screen positive 27.81 10.02 39 68571 3762 29502155
Consciousness fluctuating 27.74 10.02 21 68589 971 29504946
Congenital ureteropelvic junction obstruction 27.30 10.02 9 68601 61 29505856
Alcohol use 27.30 10.02 35 68575 3097 29502820
Psychomotor retardation 27.11 10.02 34 68576 2942 29502975
Reversible cerebral vasoconstriction syndrome 27.10 10.02 13 68597 256 29505661
Psychomotor hyperactivity 26.75 10.02 59 68551 8154 29497763
Self esteem decreased 26.65 10.02 16 68594 501 29505416
Lactic acidosis 26.37 10.02 19 68591 30228 29475689
Disorientation 25.83 10.02 136 68474 29379 29476538
Myoclonus 25.18 10.02 78 68532 13231 29492686
Depressed level of consciousness 25.01 10.02 159 68451 36783 29469134
Depressive symptom 24.91 10.02 25 68585 1692 29504225
Extrapyramidal disorder 24.84 10.02 68 68542 10763 29495154
Bradypnoea 24.72 10.02 29 68581 2342 29503575
Bruxism 24.68 10.02 24 68586 1563 29504354
Hyperthermia 24.48 10.02 62 68548 9368 29496549
Catatonia 24.39 10.02 40 68570 4428 29501489
Apraxia 24.25 10.02 21 68589 1177 29504740
Platelet count decreased 24.18 10.02 143 68467 104529 29401388
Libido increased 24.09 10.02 17 68593 704 29505213
Emotional disorder 24.07 10.02 42 68568 4889 29501028
Respiratory failure 23.89 10.02 130 68480 97001 29408916
Anhedonia 23.77 10.02 52 68558 7148 29498769
Cogwheel rigidity 23.58 10.02 21 68589 1222 29504695
Gynaecomastia 23.42 10.02 56 68554 8161 29497756
Cardiac failure 23.05 10.02 100 68510 79187 29426730
Torsade de pointes 23.01 10.02 49 68561 6612 29499305
Gambling disorder 22.97 10.02 23 68587 1552 29504365
Derealisation 22.54 10.02 15 68595 564 29505353
Agitation neonatal 22.37 10.02 19 68591 1037 29504880
Hypersomnia 22.20 10.02 65 68545 10689 29495228
Legal problem 22.18 10.02 10 68600 170 29505747
Feeling guilty 22.14 10.02 12 68598 308 29505609
Reduced facial expression 22.11 10.02 16 68594 690 29505227
Gastrointestinal hypermotility 21.93 10.02 9 68601 120 29505797
Orgasm abnormal 21.67 10.02 9 68601 124 29505793
Priapism 21.61 10.02 38 68572 4450 29501467
Neonatal respiratory distress 21.58 10.02 14 68596 504 29505413
Neonatal pneumonia 21.54 10.02 9 68601 126 29505791
Total lung capacity abnormal 21.54 10.02 9 68601 126 29505791
Pregnancy 21.50 10.02 11 68599 250 29505667
Electrocardiogram QT interval abnormal 21.46 10.02 8 68602 81 29505836
Negative thoughts 21.46 10.02 15 68595 612 29505305
Cardiac failure congestive 21.41 10.02 98 68512 76483 29429434
Off label use 21.14 10.02 534 68076 300266 29205651
Contraindicated product administered 21.05 10.02 8 68602 18258 29487659
Disseminated intravascular coagulation 21.03 10.02 10 68600 19970 29485947
Cytomegalovirus infection 21.01 10.02 14 68596 23201 29482716
Disinhibition 20.96 10.02 28 68582 2579 29503338
Tension 20.95 10.02 24 68586 1889 29504028
Burnout syndrome 20.74 10.02 9 68601 139 29505778
Physical deconditioning 20.67 10.02 16 68594 765 29505152
Abnormal dreams 20.63 10.02 48 68562 6872 29499045
Inhibitory drug interaction 20.59 10.02 21 68589 1449 29504468
Crying 20.41 10.02 41 68569 5310 29500607
Congenital hearing disorder 20.40 10.02 8 68602 94 29505823
Persecutory delusion 20.37 10.02 25 68585 2116 29503801
Parkinsonian gait 20.36 10.02 13 68597 455 29505462
Poor quality sleep 20.30 10.02 49 68561 7184 29498733
Urinary retention 20.19 10.02 135 68475 31763 29474154
Muscle necrosis 20.17 10.02 16 68594 793 29505124
Condition aggravated 19.99 10.02 462 68148 145833 29360084
Judgement impaired 19.88 10.02 14 68596 578 29505339
Cognitive disorder 19.69 10.02 107 68503 23392 29482525
Ejaculation disorder 19.66 10.02 17 68593 951 29504966
Hypoglycaemia neonatal 19.51 10.02 22 68588 1702 29504215
Trisomy 21 19.41 10.02 13 68597 494 29505423
Poisoning 19.31 10.02 59 68551 9934 29495983
Septum pellucidum agenesis 19.22 10.02 7 68603 66 29505851
Atrial septal defect 19.06 10.02 46 68564 6743 29499174
Infantile apnoea 18.91 10.02 16 68594 869 29505048
Retrograde amnesia 18.89 10.02 8 68602 116 29505801
Bronchopulmonary aspergillosis 18.87 10.02 3 68607 12341 29493576
Infection 18.72 10.02 103 68507 76648 29429269
Brain stem haematoma 18.65 10.02 8 68602 120 29505797
Mental disorder 18.56 10.02 69 68541 12836 29493081
Rash 18.30 10.02 320 68290 189499 29316418
Dysgraphia 18.12 10.02 23 68587 2015 29503902
Reactive psychosis 18.04 10.02 4 68606 3 29505914
Physical assault 18.00 10.02 17 68593 1067 29504850
Pancytopenia 17.96 10.02 116 68494 83052 29422865
Stomatitis 17.87 10.02 37 68573 37076 29468841
Pruritus 17.85 10.02 179 68431 116670 29389247
Toxic epidermal necrolysis 17.74 10.02 10 68600 18143 29487774
Bradykinesia 17.67 10.02 30 68580 3417 29502500
Congenital pulmonary hypertension 17.56 10.02 6 68604 46 29505871
Neonatal seizure 17.55 10.02 12 68598 472 29505445
Electrocardiogram QT shortened 17.48 10.02 8 68602 141 29505776
Persistent depressive disorder 17.47 10.02 10 68600 286 29505631
Death 17.44 10.02 634 67976 341450 29164467
Obsessive-compulsive disorder 17.38 10.02 35 68575 4541 29501376
Pain in extremity 17.36 10.02 168 68442 110265 29395652
Neutrophil count decreased 17.35 10.02 48 68562 43519 29462398
Ascites 17.22 10.02 37 68573 36582 29469335
Gastrointestinal haemorrhage 17.14 10.02 111 68499 79422 29426495
Inappropriate antidiuretic hormone secretion 17.04 10.02 60 68550 10872 29495045
Pelvic kidney 17.01 10.02 7 68603 94 29505823
Exposure during pregnancy 16.99 10.02 51 68559 8503 29497414
Oedema peripheral 16.94 10.02 156 68454 103401 29402516
Drug resistance 16.93 10.02 15 68595 21525 29484392
Mental impairment 16.76 10.02 53 68557 9088 29496829
Drug eruption 16.69 10.02 9 68601 16732 29489185
Hypertonia 16.63 10.02 31 68579 3798 29502119
Erythema 16.56 10.02 105 68505 75501 29430416
Urticaria 16.46 10.02 68 68542 54592 29451325
Nightmare 16.38 10.02 61 68549 11356 29494561
Feeling of despair 16.36 10.02 15 68595 907 29505010
Orthostatic hypotension 16.32 10.02 99 68511 22530 29483387
Postictal psychosis 16.25 10.02 8 68602 167 29505750
Toxic encephalopathy 16.01 10.02 34 68576 4578 29501339
Renal dysplasia 15.83 10.02 8 68602 177 29505740
Bradyphrenia 15.73 10.02 32 68578 4182 29501735
Feelings of worthlessness 15.71 10.02 9 68601 258 29505659
Personality disorder 15.65 10.02 16 68594 1107 29504810
Congenital hydronephrosis 15.62 10.02 13 68597 690 29505227
Depersonalisation/derealisation disorder 15.59 10.02 12 68598 569 29505348
Neutropenic sepsis 15.54 10.02 4 68606 11723 29494194
Cough 15.50 10.02 204 68406 126523 29379394
Stress 15.48 10.02 94 68516 21396 29484521
Medication error 15.42 10.02 93 68517 21118 29484799
Helplessness 15.42 10.02 6 68604 69 29505848
Neuropathy peripheral 15.37 10.02 99 68511 70928 29434989
Aspergillus infection 15.24 10.02 3 68607 10578 29495339
Leukopenia 15.21 10.02 71 68539 55132 29450785
Sleep-related eating disorder 15.13 10.02 9 68601 277 29505640
Neonatal hyponatraemia 15.12 10.02 6 68604 73 29505844
Alcohol abuse 15.11 10.02 32 68578 4301 29501616
Haemophagocytic lymphohistiocytosis 15.09 10.02 3 68607 10501 29495416
Head discomfort 15.03 10.02 27 68583 3215 29502702
Hyperglycaemia 15.02 10.02 36 68574 34251 29471666
Family stress 14.92 10.02 7 68603 131 29505786
Atrial fibrillation 14.85 10.02 165 68445 105481 29400436
Weight increased 14.77 10.02 255 68355 76412 29429505
Ejaculation failure 14.63 10.02 13 68597 754 29505163
Palmar-plantar erythrodysaesthesia syndrome 14.61 10.02 8 68602 14751 29491166
Dementia with Lewy bodies 14.59 10.02 12 68598 626 29505291
Hepatotoxicity 14.58 10.02 12 68598 17855 29488062
Inflammation 14.34 10.02 19 68591 22709 29483208
Muscle twitching 14.23 10.02 46 68564 7980 29497937
Sperm concentration decreased 14.14 10.02 7 68603 148 29505769
Somatic symptom disorder 14.06 10.02 11 68599 534 29505383
Pneumocystis jirovecii pneumonia 14.03 10.02 11 68599 16768 29489149
Hypersensitivity 14.02 10.02 69 68541 52834 29453083
Renal haemorrhage 13.96 10.02 16 68594 1260 29504657
Swelling 13.95 10.02 39 68571 35244 29470673
White blood cell count decreased 13.88 10.02 125 68485 83237 29422680
Tearfulness 13.82 10.02 18 68592 1618 29504299
Personality change 13.64 10.02 32 68578 4606 29501311
Stress at work 13.61 10.02 7 68603 161 29505756
Illness anxiety disorder 13.49 10.02 7 68603 164 29505753
Pneumonitis 13.46 10.02 28 68582 28016 29477901
Human herpesvirus 6 infection 13.46 10.02 19 68591 1844 29504073
Rabbit syndrome 13.32 10.02 4 68606 19 29505898
Graft versus host disease 13.32 10.02 3 68607 9625 29496292
Dementia 13.30 10.02 58 68552 11600 29494317
Panic disorder 13.15 10.02 15 68595 1175 29504742
Delusional disorder, erotomanic type 13.13 10.02 3 68607 3 29505914
Rapid eye movements sleep abnormal 13.12 10.02 7 68603 174 29505743
Tumour lysis syndrome 13.07 10.02 8 68602 13876 29492041
Device dislocation 13.06 10.02 31 68579 4496 29501421
Joint swelling 12.99 10.02 65 68545 49565 29456352
Nasopharyngitis 12.99 10.02 83 68527 59582 29446335
Loss of employment 12.94 10.02 10 68600 477 29505440
Ureteric haemorrhage 12.90 10.02 6 68604 110 29505807
Epilepsy 12.88 10.02 80 68530 18352 29487565
Yawning 12.88 10.02 10 68600 480 29505437
Feeling jittery 12.87 10.02 27 68583 3606 29502311
Social fear 12.67 10.02 3 68607 4 29505913
Arthralgia 12.61 10.02 238 68372 139379 29366538
Myocardial infarction 12.61 10.02 180 68430 110116 29395801
Somnambulism 12.59 10.02 23 68587 2775 29503142
Dizziness 12.58 10.02 549 68061 189135 29316782
Hyperammonaemic encephalopathy 12.50 10.02 19 68591 1971 29503946
Premature ejaculation 12.42 10.02 6 68604 120 29505797
Treatment failure 12.38 10.02 44 68566 36895 29469022
Symptom recurrence 12.26 10.02 8 68602 291 29505626
Thinking abnormal 12.13 10.02 33 68577 5203 29500714
Electrocardiogram abnormal 12.12 10.02 41 68569 7281 29498636
Frustration tolerance decreased 12.07 10.02 20 68590 2232 29503685
Selective eating disorder 12.07 10.02 17 68593 1646 29504271
Paresis 12.07 10.02 18 68592 1836 29504081
Congenital megaureter 12.03 10.02 6 68604 129 29505788
Carbon dioxide increased 12.01 10.02 13 68597 961 29504956
Haemoglobin decreased 11.99 10.02 178 68432 108197 29397720
Delusion of grandeur 11.85 10.02 9 68601 418 29505499
Logorrhoea 11.84 10.02 20 68590 2268 29503649
Acute myocardial infarction 11.81 10.02 65 68545 48373 29457544
Grandiosity 11.72 10.02 8 68602 314 29505603
Mucosal inflammation 11.71 10.02 36 68574 31559 29474358
Cleft lip and palate 11.69 10.02 8 68602 315 29505602
Exposure via breast milk 11.69 10.02 17 68593 1695 29504222
Hepatic failure 11.61 10.02 36 68574 31476 29474441
Sprue-like enteropathy 11.61 10.02 9 68601 431 29505486
Pleural effusion 11.46 10.02 109 68501 71799 29434118
Prescription form tampering 11.40 10.02 9 68601 443 29505474
Mood altered 11.36 10.02 43 68567 8068 29497849
Obsessive-compulsive personality disorder 11.32 10.02 6 68604 147 29505770
Back pain 11.31 10.02 168 68442 102116 29403801
Anaphylactic reaction 11.26 10.02 30 68580 27543 29478374
Chronic kidney disease 11.15 10.02 45 68565 36371 29469546
Suture rupture 11.09 10.02 8 68602 343 29505574
Attention deficit hyperactivity disorder 10.97 10.02 19 68591 2198 29503719
Post-traumatic stress disorder 10.92 10.02 16 68594 1606 29504311
Theft 10.86 10.02 7 68603 249 29505668
Obsessive thoughts 10.80 10.02 10 68600 612 29505305
Multiple drug therapy 10.77 10.02 8 68602 359 29505558
Screaming 10.77 10.02 14 68596 1256 29504661
Urogenital haemorrhage 10.76 10.02 9 68601 481 29505436
Imprisonment 10.76 10.02 9 68601 481 29505436
Behaviour disorder 10.69 10.02 25 68585 3591 29502326
Onycholysis 10.66 10.02 9 68601 487 29505430
Neonatal tachypnoea 10.63 10.02 6 68604 167 29505750
Impaired work ability 10.62 10.02 33 68577 5607 29500310
Diffuse alopecia 10.61 10.02 3 68607 11 29505906
Microvascular coronary artery disease 10.60 10.02 4 68606 42 29505875
Affect lability 10.59 10.02 24 68586 3378 29502539
Urinary incontinence 10.58 10.02 70 68540 16411 29489506
Skin exfoliation 10.54 10.02 23 68587 22622 29483295
Congenital diaphragmatic hernia 10.52 10.02 7 68603 263 29505654
Flat affect 10.52 10.02 11 68599 781 29505136
Hypocalcaemia 10.46 10.02 20 68590 20645 29485272
Dissociation 10.45 10.02 13 68597 1116 29504801
Tinnitus 10.44 10.02 67 68543 15547 29490370
Hyponatriuria 10.41 10.02 3 68607 12 29505905
Nephropathy toxic 10.40 10.02 6 68604 10750 29495167
Coronary artery disease 10.39 10.02 60 68550 44130 29461787
Feminisation acquired 10.36 10.02 4 68606 45 29505872
Hypospadias 10.27 10.02 22 68588 2980 29502937
Posterior reversible encephalopathy syndrome 10.23 10.02 4 68606 8972 29496945
Male orgasmic disorder 10.22 10.02 5 68605 103 29505814
Cerebrospinal fluid circulation disorder 10.21 10.02 3 68607 13 29505904
Soft tissue disorder 10.15 10.02 10 68600 662 29505255
Fluid retention 10.11 10.02 25 68585 23535 29482382
Compulsions 10.11 10.02 6 68604 184 29505733
Cryptorchism 10.08 10.02 17 68593 1925 29503992
Hallucination, olfactory 10.08 10.02 6 68604 185 29505732
Renal tubular necrosis 10.06 10.02 11 68599 14304 29491613
Autonomic nervous system imbalance 10.03 10.02 19 68591 2357 29503560

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 613.75 9.67 636 172305 38646 64287145
Suicide attempt 580.67 9.67 828 172113 70179 64255612
Suicidal ideation 576.91 9.67 798 172143 65744 64260047
Intentional overdose 526.32 9.67 899 172042 89045 64236746
Completed suicide 514.32 9.67 1543 171398 222871 64102920
Electrocardiogram QT prolonged 415.45 9.67 756 172185 78692 64247099
Sopor 404.63 9.67 447 172494 29214 64296577
Anxiety 324.57 9.67 1236 171705 201413 64124378
Somnolence 293.73 9.67 1202 171739 202443 64123348
Overdose 271.00 9.67 992 171949 158574 64167217
Drug interaction 232.71 9.67 1714 171227 360369 63965422
Depression 226.67 9.67 1033 171908 182258 64143533
Agitation 225.44 9.67 632 172309 87735 64238056
Tremor 216.00 9.67 878 172063 147352 64178439
Intentional self-injury 192.15 9.67 307 172634 28737 64297054
Coma 183.09 9.67 584 172357 87031 64238760
Synovitis 174.85 9.67 28 172913 99062 64226729
Poisoning deliberate 153.53 9.67 185 172756 13273 64312518
Pemphigus 147.85 9.67 3 172938 60698 64265093
Product substitution issue 146.91 9.67 209 172732 17652 64308139
Contraindicated product administered 146.37 9.67 53 172888 107776 64218015
Withdrawal syndrome 144.12 9.67 240 172701 23252 64302539
Mania 142.03 9.67 196 172745 16090 64309701
Drug intolerance 133.93 9.67 185 172756 187807 64137984
Fall 132.90 9.67 1703 171238 415123 63910668
Joint swelling 132.45 9.67 234 172707 215148 64110643
Hand deformity 130.15 9.67 10 172931 62761 64263030
Febrile neutropenia 128.41 9.67 190 172751 187467 64138324
Akathisia 124.45 9.67 154 172787 11356 64314435
Aggression 123.13 9.67 336 172605 45896 64279895
Arthropathy 123.03 9.67 87 172854 120880 64204911
Treatment failure 122.83 9.67 81 172860 116735 64209056
Inappropriate antidiuretic hormone secretion 122.66 9.67 217 172724 22072 64303719
Infusion related reaction 119.00 9.67 160 172781 164307 64161484
Paranoia 118.11 9.67 180 172761 16172 64309619
Hyponatraemia 116.89 9.67 739 172202 147600 64178191
Irritability 111.07 9.67 280 172661 36466 64289325
Panic attack 108.92 9.67 199 172742 20754 64305037
Muscle rigidity 107.84 9.67 179 172762 17294 64308497
Seizure 104.58 9.67 786 172155 166106 64159685
Torsade de pointes 103.33 9.67 175 172766 17188 64308603
Systemic lupus erythematosus 102.22 9.67 40 172901 77572 64248219
Mydriasis 100.10 9.67 161 172780 15151 64310640
Tardive dyskinesia 97.95 9.67 122 172819 9056 64316735
Acute kidney injury 94.19 9.67 762 172179 448478 63877313
Confusional state 93.48 9.67 1091 171850 260053 64065738
Disturbance in attention 90.55 9.67 279 172662 40795 64284996
Swelling 88.91 9.67 185 172756 160033 64165758
Insomnia 87.78 9.67 863 172078 196973 64128818
Sepsis 87.46 9.67 320 172621 230021 64095770
Mental disorder 86.80 9.67 208 172733 26237 64299554
Hyperhidrosis 86.68 9.67 603 172338 124317 64201474
Neutropenia 86.39 9.67 340 172601 239284 64086507
Dyskinesia 86.33 9.67 267 172674 39121 64286670
Apathy 83.05 9.67 125 172816 11107 64314684
Restlessness 82.88 9.67 265 172676 39520 64286271
Loss of consciousness 81.53 9.67 678 172263 147687 64178104
Duodenal ulcer perforation 79.57 9.67 3 172938 34622 64291169
Crying 79.28 9.67 170 172771 19920 64305871
Multiple organ dysfunction syndrome 79.23 9.67 93 172848 101320 64224471
Drug withdrawal syndrome 78.95 9.67 223 172718 31068 64294723
Helicobacter infection 77.08 9.67 7 172934 38355 64287436
Glossodynia 76.32 9.67 39 172902 64657 64261134
Neuroleptic malignant syndrome 76.09 9.67 191 172750 24805 64300986
Electrocardiogram QRS complex prolonged 75.77 9.67 108 172833 9136 64316655
Drug ineffective 75.39 9.67 1699 171242 838548 63487243
Renal impairment 73.14 9.67 158 172783 134859 64190932
Hyperreflexia 73.07 9.67 93 172848 7055 64318736
Pyrexia 72.61 9.67 1058 171883 557586 63768205
Rheumatoid arthritis 71.45 9.67 215 172726 164079 64161712
Anger 70.10 9.67 140 172801 15601 64310190
Sexual dysfunction 69.03 9.67 86 172855 6385 64319406
Peripheral swelling 69.02 9.67 307 172634 208846 64116945
Sympathomimetic effect 68.65 9.67 19 172922 52 64325739
Pericarditis 67.54 9.67 42 172899 62474 64263317
Infection 67.45 9.67 261 172680 184619 64141172
Arthralgia 67.12 9.67 811 172130 441449 63884342
Rash 66.54 9.67 849 172092 457700 63868091
Hallucination 66.48 9.67 377 172564 72411 64253380
Lower respiratory tract infection 66.44 9.67 94 172847 94520 64231271
Wound 65.44 9.67 65 172876 76412 64249379
Stomatitis 62.97 9.67 124 172817 109481 64216310
Long QT syndrome 62.50 9.67 73 172868 5066 64320725
Clonus 62.12 9.67 79 172862 5988 64319803
Psychotic disorder 62.00 9.67 219 172722 34359 64291432
Depressed mood 61.29 9.67 245 172696 40767 64285024
Interstitial lung disease 61.09 9.67 105 172836 97627 64228164
Activation syndrome 60.67 9.67 24 172917 247 64325544
Off label use 60.54 9.67 1266 171675 631540 63694251
Depressed level of consciousness 59.98 9.67 399 172542 81037 64244754
Bruxism 58.95 9.67 60 172881 3564 64322227
Septic shock 58.26 9.67 122 172819 105315 64220476
Gun shot wound 58.12 9.67 36 172905 1028 64324763
Reversible cerebral vasoconstriction syndrome 57.96 9.67 49 172892 2293 64323498
Intrusive thoughts 56.86 9.67 25 172916 342 64325449
Multiple sclerosis relapse 56.16 9.67 239 172702 40896 64284895
Derealisation 56.03 9.67 40 172901 1455 64324336
Hypersensitivity 55.79 9.67 304 172637 196148 64129643
Pancytopenia 55.74 9.67 197 172744 143112 64182679
Pneumonia 55.72 9.67 1112 171829 558464 63767327
Hallucination, auditory 55.34 9.67 133 172808 16806 64308985
Drug hypersensitivity 55.11 9.67 392 172549 237423 64088368
Extrapyramidal disorder 54.97 9.67 145 172796 19407 64306384
Cytomegalovirus infection 54.48 9.67 16 172925 37183 64288608
Abnormal behaviour 54.43 9.67 206 172735 33416 64292375
C-reactive protein abnormal 54.03 9.67 7 172934 29040 64296751
Libido decreased 53.32 9.67 65 172876 4719 64321072
Psychomotor hyperactivity 53.29 9.67 119 172822 14332 64311459
Thrombocytopenia 52.78 9.67 367 172574 223434 64102357
Hallucination, visual 52.26 9.67 179 172762 27655 64298136
Folliculitis 51.93 9.67 9 172932 30068 64295723
Anhedonia 51.82 9.67 114 172827 13592 64312199
Alopecia 51.80 9.67 248 172693 165442 64160349
Myelosuppression 51.73 9.67 3 172938 23827 64301964
Alcoholism 50.96 9.67 54 172887 3363 64322428
Inflammation 50.87 9.67 60 172881 65240 64260551
Amnesia 50.85 9.67 260 172681 48009 64277782
Cardiac failure 50.79 9.67 183 172758 132190 64193601
Platelet count decreased 50.71 9.67 254 172687 167457 64158334
Hypertonia 50.52 9.67 73 172868 6252 64319539
Muscle injury 50.08 9.67 6 172935 26431 64299360
Delusion 50.04 9.67 133 172808 17881 64307910
Homicidal ideation 49.51 9.67 52 172889 3205 64322586
Memory impairment 49.43 9.67 396 172545 85286 64240505
Bone marrow failure 49.38 9.67 34 172907 47918 64277873
Cholecystitis chronic 49.27 9.67 89 172852 9198 64316593
Impaired healing 48.81 9.67 54 172887 60419 64265372
Galactorrhoea 48.24 9.67 51 172890 3168 64322623
C-reactive protein increased 48.19 9.67 115 172826 94794 64230997
Cerebral haematoma 47.58 9.67 76 172865 7109 64318682
Libido increased 47.51 9.67 39 172902 1751 64324040
Mucosal inflammation 47.17 9.67 59 172882 62525 64263266
Loss of libido 46.96 9.67 44 172897 2360 64323431
Bipolar disorder 45.44 9.67 72 172869 6689 64319102
Psychomotor retardation 45.00 9.67 62 172879 5081 64320710
Dyspnoea 44.26 9.67 1531 171410 717143 63608648
Toxicity to various agents 44.03 9.67 1281 171660 362232 63963559
Parkinsonism 43.92 9.67 110 172831 14263 64311528
Abnormal dreams 43.61 9.67 90 172851 10266 64315525
Feeling abnormal 43.29 9.67 548 172393 133054 64192737
Major depression 42.87 9.67 76 172865 7740 64318051
Muscle twitching 42.75 9.67 130 172811 18868 64306923
Emotional distress 42.15 9.67 200 172741 35838 64289953
Anaemia 42.12 9.67 738 172203 377942 63947849
Blood creatinine increased 41.98 9.67 204 172737 135578 64190213
Tachyphrenia 41.87 9.67 37 172904 1839 64323952
Death 41.42 9.67 982 171959 481723 63844068
Hepatic enzyme increased 40.89 9.67 194 172747 129749 64196042
Hypomania 40.49 9.67 62 172879 5592 64320199
Suicidal behaviour 40.20 9.67 44 172897 2843 64322948
Dizziness 39.99 9.67 1469 171472 428694 63897097
Pregnancy 39.89 9.67 135 172806 20730 64305061
Drug screen positive 39.88 9.67 62 172879 5667 64320124
Adjustment disorder with mixed anxiety and depressed mood 39.50 9.67 13 172928 74 64325717
Disseminated intravascular coagulation 38.90 9.67 19 172922 32329 64293462
Tonsillar ulcer 38.71 9.67 20 172921 399 64325392
Pneumocystis jirovecii pneumonia 38.48 9.67 13 172928 27621 64298170
Abulia 38.46 9.67 26 172915 865 64324926
Hyperthermia 38.42 9.67 110 172831 15440 64310351
Sleep disorder 38.36 9.67 283 172658 59426 64266365
Spirometry abnormal 37.99 9.67 22 172919 554 64325237
Screaming 37.80 9.67 47 172894 3482 64322309
Bradypnoea 37.55 9.67 57 172884 5102 64320689
Malignant neoplasm progression 37.00 9.67 166 172775 112705 64213086
Multiple sclerosis 36.60 9.67 123 172818 18818 64306973
Alcohol use 36.59 9.67 53 172888 4549 64321242
Bradyphrenia 36.43 9.67 79 172862 9327 64316464
Impulsive behaviour 36.07 9.67 40 172901 2623 64323168
Neutrophil count decreased 35.75 9.67 98 172843 77098 64248693
Social avoidant behaviour 35.53 9.67 52 172889 4505 64321286
Hypersomnia 35.45 9.67 125 172816 19592 64306199
Blister 35.14 9.67 106 172835 80861 64244930
Nightmare 35.12 9.67 130 172811 20863 64304928
Hepatic function abnormal 35.03 9.67 75 172866 64238 64261553
Reversible airways obstruction 34.92 9.67 27 172914 1111 64324680
Therapeutic product effect decreased 34.11 9.67 176 172765 115175 64210616
Neutropenic sepsis 34.10 9.67 10 172931 23262 64302529
Disorientation 33.83 9.67 261 172680 55567 64270224
Abdominal discomfort 33.77 9.67 319 172622 182003 64143788
Self esteem decreased 33.14 9.67 24 172917 893 64324898
Myocardial infarction 32.95 9.67 285 172656 165536 64160255
Discomfort 32.91 9.67 109 172832 80769 64245022
Sinus bradycardia 32.80 9.67 135 172806 22758 64303033
Optic nerve injury 32.61 9.67 20 172921 561 64325230
Drug abuse 32.46 9.67 517 172424 131857 64193934
Sedation 32.26 9.67 206 172735 41256 64284535
Vital capacity decreased 31.95 9.67 25 172916 1047 64324744
Negative thoughts 31.44 9.67 27 172914 1291 64324500
Myoclonus 31.29 9.67 142 172799 24976 64300815
Emotional disorder 30.97 9.67 89 172852 12518 64313273
Oculogyric crisis 30.78 9.67 36 172905 2502 64323289
Mobility decreased 30.76 9.67 122 172819 85718 64240073
Orgasm abnormal 30.44 9.67 13 172928 165 64325626
Aspergillus infection 30.34 9.67 4 172937 16375 64309416
Anorgasmia 30.18 9.67 23 172918 926 64324865
Pain in extremity 29.86 9.67 603 172338 302482 64023309
Resting tremor 29.80 9.67 27 172914 1387 64324404
Acute myocardial infarction 29.74 9.67 92 172849 69626 64256165
Hostility 29.63 9.67 33 172908 2174 64323617
Osteoporosis 29.34 9.67 42 172899 42038 64283753
Depressive symptom 29.01 9.67 47 172894 4449 64321342
Erectile dysfunction 28.97 9.67 87 172854 12540 64313251
Generalised tonic-clonic seizure 28.56 9.67 194 172747 39663 64286128
Renal failure 28.31 9.67 331 172610 181357 64144434
Arthritis 28.23 9.67 122 172819 83692 64242099
Nasopharyngitis 27.99 9.67 364 172577 195709 64130082
Obsessive-compulsive disorder 27.92 9.67 48 172893 4770 64321021
Red blood cell sedimentation rate abnormal 27.88 9.67 5 172936 16301 64309490
Lower respiratory tract infection viral 27.88 9.67 22 172919 933 64324858
Drug resistance 27.61 9.67 32 172909 35070 64290721
Legal problem 27.44 9.67 12 172929 162 64325629
Cogwheel rigidity 27.41 9.67 36 172905 2817 64322974
Poor quality sleep 27.34 9.67 112 172829 18839 64306952
Head injury 27.32 9.67 166 172775 32676 64293115
Miosis 27.29 9.67 88 172853 13178 64312613
Pulmonary embolism 27.16 9.67 547 172394 145809 64179982
Feeling jittery 27.02 9.67 76 172865 10559 64315232
Skin ulcer 26.78 9.67 48 172893 43926 64281865
Pruritus 26.61 9.67 636 172305 311764 64014027
Behaviour disorder 26.58 9.67 45 172896 4417 64321374
Bronchopulmonary aspergillosis 26.54 9.67 9 172932 19076 64306715
Gestational diabetes 26.44 9.67 51 172890 5539 64320252
Alcohol abuse 26.38 9.67 47 172894 4805 64320986
Affective disorder 26.33 9.67 56 172885 6524 64319267
Feeling guilty 26.29 9.67 20 172921 803 64324988
Morose 26.22 9.67 8 172933 34 64325757
Persecutory delusion 26.20 9.67 43 172898 4115 64321676
Disease progression 26.18 9.67 248 172693 141432 64184359
Syncope 25.96 9.67 579 172362 157056 64168735
Electrocardiogram QT interval 25.94 9.67 11 172930 137 64325654
Disinhibition 25.85 9.67 31 172910 2212 64323579
Platelet aggregation inhibition 25.73 9.67 11 172930 140 64325651
Stiff person syndrome 25.64 9.67 13 172928 249 64325542
Feeling of despair 25.60 9.67 33 172908 2535 64323256
White blood cell count decreased 25.58 9.67 285 172656 157552 64168239
Restless legs syndrome 25.37 9.67 102 172839 17014 64308777
Thermohypoaesthesia 25.36 9.67 10 172931 102 64325689
Catatonia 25.07 9.67 60 172881 7560 64318231
Sinusitis 25.06 9.67 260 172681 145668 64180123
Haemophagocytic lymphohistiocytosis 25.02 9.67 8 172933 17601 64308190
Mood swings 25.02 9.67 103 172838 17365 64308426
Sepsis neonatal 24.85 9.67 8 172933 42 64325749
Moaning 24.61 9.67 21 172920 995 64324796
Sight disability 24.53 9.67 10 172931 112 64325679
Epilepsy 24.50 9.67 164 172777 33367 64292424
Somnambulism 24.44 9.67 47 172894 5094 64320697
Bradykinesia 24.16 9.67 54 172887 6506 64319285
Mite allergy 24.05 9.67 18 172923 705 64325086
Haemoglobin decreased 24.00 9.67 373 172568 194690 64131101
Initial insomnia 23.92 9.67 50 172891 5754 64320037
Respiratory arrest 23.87 9.67 232 172709 52753 64273038
Bundle branch block left 23.84 9.67 70 172871 9964 64315827
Poisoning 23.84 9.67 119 172822 21760 64304031
Learning disorder 23.73 9.67 16 172925 530 64325261
Pyramidal tract syndrome 23.67 9.67 16 172925 532 64325259
Bradycardia 23.67 9.67 447 172494 117772 64208019
Judgement impaired 23.62 9.67 21 172920 1052 64324739
Dysgraphia 23.38 9.67 37 172904 3434 64322357
Tachycardia 23.26 9.67 545 172396 149034 64176757
Dysphoria 23.21 9.67 42 172899 4346 64321445
Angle closure glaucoma 23.20 9.67 32 172909 2625 64323166
Maternal exposure during pregnancy 23.19 9.67 156 172785 95728 64230063
Weight increased 23.14 9.67 742 172199 212606 64113185
Knee arthroplasty 23.03 9.67 23 172918 26976 64298815
Product use issue 23.01 9.67 278 172663 151437 64174354
Device dislocation 22.95 9.67 115 172826 21063 64304728
Mental status changes 22.93 9.67 258 172683 60904 64264887
Neuropathy peripheral 22.89 9.67 203 172738 117322 64208469
Transplant rejection 22.85 9.67 9 172932 17392 64308399
Cardiac failure congestive 22.69 9.67 232 172709 130348 64195443
Postictal state 22.68 9.67 25 172916 1628 64324163
Nervousness 22.47 9.67 146 172795 29410 64296381
Orthostatic hypotension 22.22 9.67 207 172734 46531 64279260
Cough 21.80 9.67 630 172311 301518 64024273
Ejaculation failure 21.74 9.67 13 172928 348 64325443
Erythema 21.59 9.67 362 172579 186708 64139083
Blood prolactin increased 21.58 9.67 36 172905 3492 64322299
Uterine perforation 21.54 9.67 48 172893 5772 64320019
Atrial fibrillation 21.44 9.67 326 172615 170763 64155028
Self-injurious ideation 21.42 9.67 34 172907 3163 64322628
Bronchial secretion retention 21.41 9.67 30 172911 2497 64323294
Thinking abnormal 21.41 9.67 74 172867 11482 64314309
Rheumatoid nodule 21.37 9.67 4 172937 12647 64313144
Tearfulness 21.33 9.67 42 172899 4631 64321160
Tumour lysis syndrome 21.08 9.67 13 172928 19427 64306364
Middle insomnia 20.92 9.67 79 172862 12798 64312993
Sinus tachycardia 20.92 9.67 153 172788 32035 64293756
Irritable bowel syndrome 20.83 9.67 43 172898 37326 64288465
Band sensation 20.81 9.67 16 172925 653 64325138
Antiphospholipid antibodies 20.74 9.67 9 172932 119 64325672
Tension 20.63 9.67 37 172904 3803 64321988
Sleep-related eating disorder 20.53 9.67 16 172925 666 64325125
Tubulointerstitial nephritis 20.43 9.67 32 172909 30877 64294914
Anaphylactic shock 20.43 9.67 31 172910 30297 64295494
Ascites 20.42 9.67 91 172850 61910 64263881
Cellulitis 20.41 9.67 157 172784 93500 64232291
Lip ulceration 20.40 9.67 26 172915 1975 64323816
Heavy menstrual bleeding 20.38 9.67 75 172866 12002 64313789
Hyperglycaemia 20.38 9.67 89 172852 60879 64264912
Victim of sexual abuse 20.30 9.67 13 172928 394 64325397
Conversion disorder 20.21 9.67 24 172917 1695 64324096
Pain 20.21 9.67 1247 171694 552264 63773527
Foetal exposure during pregnancy 20.16 9.67 40 172901 4436 64321355
Dystonia 20.13 9.67 102 172839 18763 64307028
Mental impairment 20.06 9.67 92 172849 16251 64309540
Slow speech 20.03 9.67 26 172915 2011 64323780
Delirium 19.98 9.67 278 172663 68916 64256875
Headache 19.93 9.67 1663 171278 527804 63797987
Gambling disorder 19.93 9.67 25 172916 1869 64323922
Respiratory failure 19.89 9.67 308 172633 160875 64164916
Post-traumatic neck syndrome 19.84 9.67 25 172916 1877 64323914
Bipolar I disorder 19.64 9.67 24 172917 1747 64324044
Device expulsion 19.63 9.67 110 172831 21026 64304765
Migraine 19.40 9.67 255 172686 62422 64263369
Treatment noncompliance 19.40 9.67 190 172751 43292 64282499
Hypertension 19.35 9.67 538 172403 258723 64067068
Chest injury 19.32 9.67 28 172913 2405 64323386
Reduced facial expression 19.28 9.67 26 172915 2087 64323704
Logorrhoea 19.16 9.67 37 172904 4022 64321769
Family stress 19.01 9.67 15 172926 636 64325155
Bone erosion 18.89 9.67 4 172937 11591 64314200
Carcinoid syndrome 18.82 9.67 9 172932 151 64325640
Hypervigilance 18.80 9.67 13 172928 449 64325342
Fear 18.75 9.67 105 172836 20066 64305725
Immobilisation prolonged 18.70 9.67 8 172933 102 64325689
Euphoric mood 18.65 9.67 49 172892 6542 64319249
Self-medication 18.62 9.67 37 172904 4108 64321683
Acute myeloid leukaemia 18.57 9.67 28 172913 27435 64298356
Conjunctivitis allergic 18.50 9.67 18 172923 1012 64324779
Biliary dyskinesia 18.40 9.67 27 172914 2345 64323446
Graft versus host disease 18.38 9.67 7 172934 13806 64311985
Gynaecomastia 18.34 9.67 46 172895 5970 64319821
Nausea 18.32 9.67 2389 170552 783411 63542380
Painful respiration 18.26 9.67 31 172910 3050 64322741
Breast swelling 18.24 9.67 18 172923 1030 64324761
Red blood cell sedimentation rate increased 18.22 9.67 35 172906 31200 64294591
Tongue biting 18.15 9.67 23 172918 1737 64324054
Retroplacental haematoma 18.03 9.67 8 172933 112 64325679
Dry mouth 17.96 9.67 244 172697 60174 64265617
Illness anxiety disorder 17.77 9.67 10 172931 238 64325553
Drug withdrawal syndrome neonatal 17.62 9.67 10 172931 242 64325549
Personality disorder 17.60 9.67 39 172902 4672 64321119
Head banging 17.60 9.67 13 172928 499 64325292
Hepatotoxicity 17.56 9.67 52 172889 39910 64285881
Intermenstrual bleeding 17.56 9.67 41 172900 5084 64320707
Leukopenia 17.53 9.67 180 172761 101062 64224729
Parkinsonian gait 17.48 9.67 16 172925 833 64324958
Obsessive-compulsive personality disorder 17.42 9.67 8 172933 122 64325669
Injury 17.42 9.67 228 172713 55764 64270027
Hip arthroplasty 17.30 9.67 19 172922 21332 64304459
Nephropathy toxic 17.27 9.67 13 172928 17501 64308290
Torticollis 17.20 9.67 25 172916 2152 64323639
Mycotic allergy 17.11 9.67 17 172924 981 64324810
Palmar-plantar erythrodysaesthesia syndrome 17.07 9.67 32 172909 28787 64297004
Barotrauma 17.01 9.67 9 172932 189 64325602
Colitis microscopic 16.86 9.67 51 172890 7381 64318410
Obsessive thoughts 16.84 9.67 17 172924 1000 64324791
Ill-defined disorder 16.82 9.67 61 172880 43991 64281800
Skin dystrophy 16.71 9.67 6 172935 46 64325745
Deep vein thrombosis 16.58 9.67 384 172557 104798 64220993
Suspected suicide 16.55 9.67 56 172885 8598 64317193
Grandiosity 16.46 9.67 13 172928 552 64325239
Enthesopathy 16.38 9.67 3 172938 9635 64316156
Dust allergy 16.34 9.67 17 172924 1036 64324755
Decreased interest 16.32 9.67 31 172910 3329 64322462
Male orgasmic disorder 16.28 9.67 6 172935 50 64325741
Trunk injury 16.25 9.67 5 172936 22 64325769
Pleural effusion 16.24 9.67 240 172701 126319 64199472
Speech disorder 16.23 9.67 200 172741 48241 64277550
Enterocolitis 16.14 9.67 6 172935 12012 64313779
Neoplasm progression 16.12 9.67 56 172885 40908 64284883
Kidney transplant rejection 16.08 9.67 3 172938 9508 64316283
Colitis 15.98 9.67 92 172849 58582 64267209
Pneumonitis 15.95 9.67 75 172866 50290 64275501
Bundle branch block right 15.86 9.67 62 172879 10207 64315584
Large intestine anastomosis 15.84 9.67 7 172934 97 64325694
Partner stress 15.83 9.67 10 172931 296 64325495
Cerebral thrombosis 15.73 9.67 24 172917 2158 64323633
Hemianopia 15.69 9.67 20 172921 1519 64324272
Retrograde amnesia 15.66 9.67 12 172929 487 64325304
Freezing phenomenon 15.62 9.67 20 172921 1526 64324265
Road traffic accident 15.55 9.67 138 172803 30607 64295184
Epstein-Barr virus infection 15.53 9.67 7 172934 12481 64313310
Ocular hypertension 15.48 9.67 18 172923 1243 64324548
Coma scale abnormal 15.48 9.67 51 172890 7723 64318068
Rectal ulcer 15.47 9.67 22 172919 1857 64323934
Left ventricle outflow tract obstruction 15.44 9.67 10 172931 309 64325482
Neuromyelitis optica spectrum disorder 15.44 9.67 15 172926 842 64324949
Gallbladder disorder 15.40 9.67 88 172853 16942 64308849
Soft tissue injury 15.29 9.67 20 172921 1559 64324232
Schizoaffective disorder 15.21 9.67 20 172921 1567 64324224
Inappropriate affect 15.17 9.67 18 172923 1270 64324521
Drug screen false positive 15.10 9.67 16 172925 996 64324795
Sleep talking 15.06 9.67 16 172925 999 64324792
Anterograde amnesia 15.04 9.67 13 172928 627 64325164
Reactive psychosis 15.01 9.67 4 172937 9 64325782
Angina pectoris 14.95 9.67 66 172875 45015 64280776
Cerebellar syndrome 14.92 9.67 38 172903 4978 64320813
Postural orthostatic tachycardia syndrome 14.90 9.67 12 172929 524 64325267
Neurotoxicity 14.88 9.67 32 172909 27372 64298419
Imprisonment 14.87 9.67 12 172929 526 64325265
Brain stem haematoma 14.72 9.67 7 172934 116 64325675
Compulsions 14.70 9.67 10 172931 336 64325455
Pneumonia fungal 14.59 9.67 3 172938 8874 64316917
Psychomotor skills impaired 14.56 9.67 32 172909 3813 64321978
Spinal cord oedema 14.50 9.67 10 172931 344 64325447
Hypophosphataemia 14.42 9.67 11 172930 14709 64311082
Focal dyscognitive seizures 14.34 9.67 29 172912 3261 64322530
Urinary retention 14.33 9.67 198 172743 49003 64276788
Coronary artery disease 14.27 9.67 99 172842 60334 64265457
Caesarean section 14.24 9.67 64 172877 11210 64314581
Haemoglobin urine 14.20 9.67 7 172934 126 64325665
Foot deformity 14.14 9.67 14 172927 16490 64309301
Diarrhoea 14.10 9.67 1710 171231 720994 63604797
Autonomic nervous system imbalance 14.10 9.67 33 172908 4099 64321692
Hepatitis infectious mononucleosis 14.10 9.67 7 172934 128 64325663
Ovarian vein thrombosis 14.08 9.67 5 172936 37 64325754
Hydrops foetalis 14.06 9.67 6 172935 76 64325715
Osteonecrosis of jaw 14.01 9.67 57 172884 39768 64286023
Gastrointestinal haemorrhage 13.99 9.67 260 172681 132052 64193739
Intraventricular haemorrhage 13.99 9.67 33 172908 4120 64321671
Hyperphagia 13.96 9.67 23 172918 2208 64323583
Myositis 13.91 9.67 14 172927 16363 64309428
Hypokinesia 13.87 9.67 84 172857 16512 64309279
Flight of ideas 13.86 9.67 13 172928 698 64325093
Electrocardiogram QT interval abnormal 13.85 9.67 9 172932 280 64325511
Apnoea 13.80 9.67 60 172881 10362 64315429
Delusion of grandeur 13.72 9.67 12 172929 588 64325203
Product substitution error 13.64 9.67 5 172936 41 64325750
Sputum culture positive 13.58 9.67 27 172914 2999 64322792
Dysarthria 13.43 9.67 229 172712 59177 64266614
Extradural haematoma 13.38 9.67 25 172916 2651 64323140
Musculoskeletal stiffness 13.37 9.67 241 172700 122965 64202826
Device related infection 13.35 9.67 40 172901 30586 64295205
Cardio-respiratory arrest 13.35 9.67 352 172589 98041 64227750
Device placement issue 13.33 9.67 13 172928 733 64325058
Abortion spontaneous 13.31 9.67 114 172827 25029 64300762
Belligerence 13.27 9.67 9 172932 301 64325490
Neoplasm malignant 13.27 9.67 29 172912 24659 64301132
Psychiatric symptom 13.26 9.67 42 172899 6231 64319560
Drug use disorder 13.22 9.67 41 172900 6013 64319778
Ventricular dyskinesia 13.22 9.67 10 172931 398 64325393
Peripheral sensory neuropathy 13.21 9.67 7 172934 11371 64314420
Metabolic acidosis 13.19 9.67 124 172817 70834 64254957
Drug eruption 13.17 9.67 51 172890 36085 64289706
Concussion 13.15 9.67 49 172892 7889 64317902
Respiratory disorder 13.14 9.67 51 172890 36060 64289731
Electrocardiogram abnormal 13.08 9.67 71 172870 13410 64312381
Pulmonary fibrosis 13.04 9.67 39 172902 29839 64295952
Lethargy 13.02 9.67 270 172671 72324 64253467
Cytotoxic oedema 12.96 9.67 9 172932 313 64325478
Compulsive shopping 12.89 9.67 13 172928 764 64325027
Atrial flutter 12.87 9.67 20 172921 19360 64306431
Total lung capacity abnormal 12.85 9.67 7 172934 156 64325635
Hyperventilation 12.85 9.67 44 172897 6796 64318995
Menometrorrhagia 12.80 9.67 12 172929 644 64325147
Cardiogenic shock 12.70 9.67 138 172803 32289 64293502
Muscle necrosis 12.64 9.67 16 172925 1207 64324584
Creatinine renal clearance decreased 12.63 9.67 12 172929 14409 64311382
Hypermetropia 12.61 9.67 10 172931 427 64325364
Bacteraemia 12.58 9.67 34 172907 26877 64298914
Impaired driving ability 12.56 9.67 34 172907 4620 64321171
Osteoarthritis 12.50 9.67 109 172832 63227 64262564
Vertigo 12.46 9.67 225 172716 58786 64267005
Alcohol poisoning 12.41 9.67 32 172909 4223 64321568
Inhibitory drug interaction 12.41 9.67 29 172912 3598 64322193
Pelvic pain 12.36 9.67 60 172881 10850 64314941
Ileus 12.32 9.67 27 172914 22939 64302852
Basal cell carcinoma 12.24 9.67 42 172899 30796 64294995
Arthritis bacterial 12.18 9.67 3 172938 7836 64317955
Bile acid malabsorption 12.17 9.67 7 172934 174 64325617
Superior sagittal sinus thrombosis 12.10 9.67 14 172927 962 64324829
Electroencephalogram abnormal 12.08 9.67 36 172905 5167 64320624
Aphasia 12.07 9.67 165 172776 40741 64285050
Attention-seeking behaviour 12.07 9.67 6 172935 110 64325681
Joint hyperextension 12.05 9.67 8 172933 258 64325533
Fibromyalgia 12.04 9.67 52 172889 35679 64290112
Retching 11.99 9.67 76 172865 15180 64310611
Pulmonary toxicity 11.97 9.67 4 172937 8557 64317234
Hepatitis chronic active 11.96 9.67 7 172934 180 64325611
Complication of device insertion 11.94 9.67 35 172906 4977 64320814
Xerophthalmia 11.86 9.67 10 172931 466 64325325
Retinal ischaemia 11.86 9.67 12 172929 708 64325083
Sialoadenitis 11.83 9.67 18 172923 1615 64324176
Extensor plantar response 11.77 9.67 18 172923 1622 64324169
Priapism 11.73 9.67 30 172911 3940 64321851
Unresponsive to stimuli 11.66 9.67 195 172746 50198 64275593
Rash maculo-papular 11.62 9.67 76 172865 46950 64278841
Sperm concentration decreased 11.60 9.67 5 172936 65 64325726
Nephropathy 11.58 9.67 4 172937 8382 64317409
Mood altered 11.58 9.67 78 172863 15901 64309890
Laryngectomy 11.58 9.67 4 172937 27 64325764
Hyperkalaemia 11.56 9.67 196 172745 100933 64224858
Anti-actin antibody positive 11.49 9.67 3 172938 6 64325785
Wound healing normal 11.49 9.67 3 172938 6 64325785
Tinnitus 11.47 9.67 141 172800 33992 64291799
Ejection fraction decreased 11.46 9.67 39 172902 28668 64297123
Panic reaction 11.46 9.67 30 172911 3997 64321794
Gambling 11.45 9.67 8 172933 281 64325510
Stoma site discharge 11.42 9.67 18 172923 1664 64324127
Hyperdynamic left ventricle 11.40 9.67 8 172933 283 64325508
Psoriasis 11.36 9.67 262 172679 71441 64254350
Female orgasmic disorder 11.33 9.67 4 172937 29 64325762
Ejaculation disorder 11.30 9.67 10 172931 498 64325293
Drug-induced liver injury 11.27 9.67 78 172863 47565 64278226
General physical health deterioration 11.26 9.67 441 172500 203984 64121807
Optic atrophy 11.26 9.67 18 172923 1685 64324106
Endometrial disorder 11.25 9.67 10 172931 501 64325290
Thrombotic microangiopathy 11.24 9.67 17 172924 16638 64309153
Upper-airway cough syndrome 11.24 9.67 50 172891 8720 64317071
Angina unstable 11.22 9.67 15 172926 15452 64310339
Prescribed overdose 11.19 9.67 93 172848 20238 64305553
Paraesthesia 11.17 9.67 454 172487 134068 64191723
Yawning 11.15 9.67 15 172926 1201 64324590
Diffuse large B-cell lymphoma 11.13 9.67 7 172934 10354 64315437
Anaphylactic reaction 11.11 9.67 124 172817 68540 64257251
Hot flush 11.10 9.67 180 172761 46055 64279736
Product use in unapproved indication 11.08 9.67 375 172566 176243 64149548
Mucormycosis 11.04 9.67 3 172938 7338 64318453
Balance disorder 11.02 9.67 299 172642 83627 64242164
Hypogammaglobulinaemia 11.01 9.67 7 172934 10292 64315499
Burnout syndrome 10.99 9.67 8 172933 300 64325491
Nephrotic syndrome 10.94 9.67 6 172935 9561 64316230
Merycism 10.91 9.67 7 172934 213 64325578
Carboxyhaemoglobin increased 10.89 9.67 4 172937 33 64325758
Metastases to lung 10.87 9.67 15 172926 15249 64310542
Intentional product use issue 10.84 9.67 185 172756 95179 64230612
Musculoskeletal pain 10.83 9.67 153 172788 81141 64244650
Pulmonary tuberculosis 10.82 9.67 3 172938 7241 64318550
Cytokine release syndrome 10.76 9.67 25 172916 20804 64304987
Creatinine urine decreased 10.73 9.67 7 172934 219 64325572
Posterior reversible encephalopathy syndrome 10.72 9.67 29 172912 22917 64302874
Nuchal rigidity 10.68 9.67 13 172928 942 64324849
Cholangitis 10.67 9.67 8 172933 10794 64314997
Cataract 10.67 9.67 87 172854 51175 64274616
Cardiac arrest 10.60 9.67 510 172431 153554 64172237
Delusional disorder, erotomanic type 10.58 9.67 4 172937 36 64325755
Cognitive disorder 10.58 9.67 207 172734 54880 64270911
Amenorrhoea 10.53 9.67 40 172901 6499 64319292
Pseudomonas infection 10.46 9.67 20 172921 17863 64307928
Liver disorder 10.45 9.67 92 172849 53259 64272532
Hypercalcaemia 10.41 9.67 46 172895 31370 64294421
Blood urea nitrogen/creatinine ratio decreased 10.40 9.67 5 172936 85 64325706
Blood gases abnormal 10.38 9.67 13 172928 970 64324821
Suture rupture 10.34 9.67 10 172931 558 64325233
Lymphadenopathy 10.29 9.67 78 172863 46608 64279183
Homicide 10.26 9.67 14 172927 1137 64324654
Cytopenia 10.24 9.67 16 172925 15455 64310336
Dissociation 10.22 9.67 24 172917 2987 64322804
Staring 10.21 9.67 21 172920 2389 64323402
Emotional poverty 10.21 9.67 11 172930 698 64325093
Lung consolidation 10.21 9.67 4 172937 7754 64318037
Dermatitis atopic 10.14 9.67 28 172913 3848 64321943
Shoulder deformity 10.13 9.67 4 172937 41 64325750
Flat affect 10.11 9.67 18 172923 1839 64323952
Inflammatory marker increased 10.11 9.67 5 172936 8446 64317345
Foreign body in reproductive tract 10.10 9.67 9 172932 452 64325339
Drug dependence 10.09 9.67 135 172806 33177 64292614
Oedema peripheral 10.05 9.67 461 172480 209856 64115935
Sternal fracture 10.02 9.67 20 172921 2227 64323564
Hypochloraemia 9.99 9.67 19 172922 2042 64323749
Blood alcohol increased 9.97 9.67 14 172927 1168 64324623
Cerebellar haematoma 9.95 9.67 10 172931 585 64325206
Wheezing 9.93 9.67 154 172787 80425 64245366
Lactic acidosis 9.90 9.67 111 172830 61299 64264492
Polyarthritis 9.85 9.67 7 172934 9708 64316083
Erection increased 9.85 9.67 8 172933 354 64325437
Choroidal effusion 9.71 9.67 10 172931 602 64325189
Polydipsia 9.70 9.67 36 172905 5785 64320006

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Human herpesvirus 6 infection 34.35 33.45 15 812 45 83806

Pharmacologic Action:

SourceCodeDescription
ATC N06AB10 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:76779 post-proline endopeptidase inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Major depressive disorder indication 370143000
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Obsessive-compulsive disorder off-label use 191736004 DOID:10933
Menopausal flushing off-label use 198436008
Panic disorder off-label use 371631005 DOID:594
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Upper gastrointestinal hemorrhage contraindication 37372002
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Heart disease contraindication 56265001 DOID:114
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Epilepsy contraindication 84757009 DOID:1826
Hyponatremia contraindication 89627008
Disease of liver contraindication 235856003 DOID:409
Serotonin syndrome contraindication 371089000
Myocardial infarction in recovery phase contraindication 418044006




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Ki 8.96 WOMBAT-PK CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.19 PDSP
5-hydroxytryptamine receptor 2C GPCR Ki 5.60 PDSP
Alpha-1A adrenergic receptor GPCR Ki 5.41 PDSP
Histamine H1 receptor GPCR Ki 5.71 PDSP
Muscarinic acetylcholine receptor M1 GPCR Ki 5.91 PDSP
Sodium-dependent serotonin transporter Transporter Ki 9.05 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.09 CHEMBL
Transporter Transporter Ki 4.98 CHEMBL

External reference:

IDSource
4024285 VUID
N0000022289 NUI
D02567 KEGG_DRUG
219861-08-2 SECONDARY_CAS_RN
4021356 VANDF
4024285 VANDF
C1099456 UMLSCUI
CHEBI:36791 CHEBI
68P PDB_CHEM_ID
CHEMBL1508 ChEMBL_ID
DB01175 DRUGBANK_ID
CHEMBL1200322 ChEMBL_ID
D000089983 MESH_DESCRIPTOR_UI
146570 PUBCHEM_CID
7177 IUPHAR_LIGAND_ID
7953 INN_ID
4O4S742ANY UNII
321988 RXNORM
158618 MMSL
16927 MMSL
187848 MMSL
d04812 MMSL
009709 NDDF
009710 NDDF
395246009 SNOMEDCT_US
400447003 SNOMEDCT_US
412384000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0121-0852 SOLUTION 10 mg ORAL ANDA 36 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2005 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2005 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2010 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2010 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2020 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2020 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2101 SOLUTION 5 mg ORAL NDA 32 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2101 SOLUTION 5 mg ORAL NDA 32 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7953 TABLET 5 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7954 TABLET 10 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7955 TABLET 20 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8348 TABLET, FILM COATED 5 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8349 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8350 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8365 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8366 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6426 TABLET 10 mg ORAL ANDA 30 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6426 TABLET 10 mg ORAL ANDA 30 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6427 TABLET 20 mg ORAL ANDA 30 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6427 TABLET 20 mg ORAL ANDA 30 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-224 TABLET 5 mg ORAL ANDA 29 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-225 TABLET 10 mg ORAL ANDA 29 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-230 TABLET 20 mg ORAL ANDA 29 sections
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-968 TABLET, FILM COATED 10 mg ORAL NDA authorized generic 32 sections
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-969 TABLET, FILM COATED 20 mg ORAL NDA authorized generic 32 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 13668-135 TABLET 5 mg ORAL ANDA 28 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 13668-135 TABLET 5 mg ORAL ANDA 28 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 13668-136 TABLET 10 mg ORAL ANDA 28 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 13668-136 TABLET 10 mg ORAL ANDA 28 sections