escitalopram 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1053 128196-01-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • escitalopram
  • (+)-(S)-Citalopram
  • (+)-Citalopram
  • (S)-Citalopram
  • S-(+)-Citalopram
  • seroplex
  • escitalopram oxalate
  • Molecular weight: 324.40
  • Formula: C20H21FN2O
  • CLOGP: 3.13
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 36.26
  • ALOGS: -4.74
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.88 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Aug. 14, 2002 FDA FOREST LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Suicide attempt 505.56 9.59 720 160217 57116 56074014
Suicidal ideation 499.10 9.59 715 160222 57027 56074103
Depression 498.64 9.59 1381 159556 178736 55952394
Intentional overdose 488.44 9.59 773 160164 67344 56063786
Anxiety 476.58 9.59 1421 159516 191751 55939379
Electrocardiogram QT prolonged 464.54 9.59 671 160266 53917 56077213
Rheumatoid arthritis 438.49 9.59 277 160660 382327 55748803
Pemphigus 427.19 9.59 4 160933 157208 55973922
Serotonin syndrome 385.91 9.59 426 160511 26064 56105066
Systemic lupus erythematosus 353.63 9.59 48 160889 180030 55951100
Contraindicated product administered 337.94 9.59 62 160875 186224 55944906
Synovitis 331.38 9.59 37 160900 161268 55969862
Hand deformity 331.34 9.59 12 160925 134480 55996650
Sopor 326.65 9.59 349 160588 20573 56110557
Glossodynia 296.09 9.59 42 160895 152416 55978714
Completed suicide 287.59 9.59 939 159998 132894 55998236
Arthropathy 286.78 9.59 107 160830 200168 55930962
Drug interaction 280.30 9.59 1265 159672 208490 55922640
Overdose 273.43 9.59 792 160145 105038 56026092
Somnolence 265.30 9.59 1046 159891 162367 55968763
Treatment failure 264.95 9.59 79 160858 170313 55960817
Joint swelling 252.30 9.59 274 160663 289526 55841604
Drug intolerance 222.13 9.59 258 160679 264560 55866570
Swelling 218.43 9.59 218 160719 239553 55891577
Wound 209.22 9.59 68 160869 138736 55992394
Infusion related reaction 205.59 9.59 177 160760 208754 55922376
Pericarditis 204.58 9.59 33 160904 108890 56022240
Alopecia 200.00 9.59 332 160605 293126 55838004
Tremor 194.70 9.59 773 160164 120316 56010814
Intentional self-injury 183.66 9.59 287 160650 24705 56106425
Rheumatoid factor positive 182.00 9.59 3 160934 69057 56062073
Duodenal ulcer perforation 179.97 9.59 3 160934 68339 56062791
Hyponatraemia 179.71 9.59 671 160266 101468 56029662
Helicobacter infection 178.81 9.59 7 160930 73261 56057869
Drug ineffective 177.00 9.59 1730 159207 917259 55213871
Product substitution issue 161.51 9.59 204 160733 14395 56116735
Abdominal discomfort 144.43 9.59 366 160571 276908 55854222
Agitation 142.33 9.59 417 160520 55619 56075511
Therapeutic product effect decreased 140.98 9.59 166 160771 169286 55961844
Inappropriate antidiuretic hormone secretion 140.85 9.59 185 160752 13571 56117559
Coma 139.33 9.59 431 160506 59224 56071906
Lower respiratory tract infection 131.27 9.59 83 160854 114711 56016419
Akathisia 127.45 9.59 140 160797 8512 56122618
Folliculitis 125.43 9.59 8 160929 54971 56076159
Hepatic enzyme increased 125.08 9.59 185 160752 171199 55959931
Muscle injury 121.70 9.59 7 160930 52493 56078637
Discomfort 115.63 9.59 141 160796 141620 55989510
Arthralgia 114.34 9.59 903 160034 500766 55630364
Peripheral swelling 113.74 9.59 321 160616 234405 55896725
Hypersensitivity 109.81 9.59 371 160566 256037 55875093
Drug abuse 107.28 9.59 430 160507 67180 56063950
Maternal exposure during pregnancy 106.73 9.59 240 160697 189313 55941817
Rash 106.62 9.59 900 160037 492147 55638983
Withdrawal syndrome 104.92 9.59 189 160748 18273 56112857
Impaired healing 103.17 9.59 60 160877 86781 56044349
Seizure 101.03 9.59 658 160279 124461 56006669
Irritability 99.15 9.59 244 160693 29344 56101786
Mania 98.47 9.59 142 160795 11378 56119752
Fall 98.22 9.59 1500 159437 356010 55775120
Tardive dyskinesia 98.15 9.59 118 160819 7913 56123217
Panic attack 94.84 9.59 192 160745 20255 56110875
Drug hypersensitivity 92.62 9.59 438 160499 274767 55856363
Stomatitis 92.48 9.59 126 160811 120684 56010446
Blister 91.24 9.59 106 160831 108781 56022349
Poisoning deliberate 89.97 9.59 126 160811 9827 56121303
Infection 88.90 9.59 285 160652 199921 55931209
Product use issue 88.19 9.59 257 160680 185784 55945346
Torsade de pointes 87.44 9.59 140 160797 12300 56118830
Muscle rigidity 83.24 9.59 126 160811 10545 56120585
Dyskinesia 83.07 9.59 226 160711 28882 56102248
Mental disorder 81.59 9.59 197 160740 23407 56107723
Loss of consciousness 80.43 9.59 562 160375 108787 56022343
Crying 78.50 9.59 183 160754 21257 56109873
Pain 77.19 9.59 1384 159553 661800 55469330
Sympathomimetic effect 76.02 9.59 20 160917 38 56131092
Disturbance in attention 74.93 9.59 234 160703 32306 56098824
C-reactive protein abnormal 74.13 9.59 9 160928 36800 56094330
Depressed mood 72.53 9.59 249 160688 36110 56095020
Long QT syndrome 71.83 9.59 64 160873 3012 56128118
Mydriasis 71.60 9.59 120 160817 10951 56120179
Tonsillar ulcer 70.37 9.59 28 160909 273 56130857
Insomnia 70.24 9.59 848 160089 191012 55940118
Hyperhidrosis 70.03 9.59 485 160452 93603 56037527
Toxicity to various agents 68.96 9.59 961 159976 223603 55907527
Restlessness 68.59 9.59 199 160738 26387 56104743
Extrapyramidal disorder 68.31 9.59 125 160812 12231 56118899
Psychotic disorder 66.32 9.59 182 160755 23376 56107754
Paranoia 64.93 9.59 113 160824 10631 56120499
Irritable bowel syndrome 64.84 9.59 60 160877 68398 56062732
Mobility decreased 64.54 9.59 115 160822 98876 56032254
Dizziness 63.81 9.59 1465 159472 374675 55756455
Neuroleptic malignant syndrome 63.31 9.59 116 160821 11362 56119768
Emotional distress 63.05 9.59 208 160729 29555 56101575
Hallucination, auditory 62.98 9.59 116 160821 11408 56119722
Febrile neutropenia 62.37 9.59 130 160807 105415 56025715
Reversible airways obstruction 61.18 9.59 42 160895 1342 56129788
Bronchial secretion retention 60.56 9.59 47 160890 1821 56129309
Off label use 60.17 9.59 1175 159762 555005 55576125
Apathy 59.34 9.59 92 160845 7862 56123268
Vital capacity decreased 59.10 9.59 40 160897 1248 56129882
Cholecystitis chronic 58.23 9.59 102 160835 9646 56121484
Suicidal behaviour 57.57 9.59 51 160886 2382 56128748
C-reactive protein increased 57.29 9.59 85 160852 78599 56052531
Stiff person syndrome 56.46 9.59 25 160912 325 56130805
Hip arthroplasty 56.28 9.59 20 160917 38603 56092527
Galactorrhoea 55.60 9.59 62 160875 3833 56127297
Hypertonia 54.78 9.59 63 160874 4029 56127101
Multiple sclerosis relapse 54.77 9.59 264 160673 44639 56086491
Reversible cerebral vasoconstriction syndrome 54.60 9.59 49 160888 2328 56128802
Feeling abnormal 53.98 9.59 602 160335 133000 55998130
Ill-defined disorder 53.95 9.59 70 160867 68473 56062657
Drug withdrawal syndrome neonatal 53.25 9.59 45 160892 1971 56129159
Depressed level of consciousness 53.21 9.59 309 160628 56124 56075006
Pregnancy 52.30 9.59 210 160727 32823 56098307
Hallucination, visual 52.23 9.59 138 160799 17330 56113800
Inflammation 51.88 9.59 73 160864 68998 56062132
Abnormal behaviour 50.62 9.59 150 160787 20122 56111008
Knee arthroplasty 50.57 9.59 32 160905 44227 56086903
Psychomotor hyperactivity 50.12 9.59 96 160841 9724 56121406
Hyperreflexia 49.75 9.59 68 160869 5182 56125948
Sepsis 49.69 9.59 218 160719 139622 55991508
Lower respiratory tract infection viral 48.59 9.59 30 160907 797 56130333
Sputum culture positive 48.38 9.59 40 160897 1699 56129431
Death 48.07 9.59 687 160250 340739 55790391
Aggression 47.70 9.59 155 160782 21851 56109279
Electrocardiogram QRS complex prolonged 47.62 9.59 68 160869 5399 56125731
Miosis 47.44 9.59 75 160862 6517 56124613
Sinusitis 47.01 9.59 351 160586 197230 55933900
Amnesia 46.54 9.59 258 160679 46064 56085066
Oculogyric crisis 46.51 9.59 37 160900 1487 56129643
Pulmonary embolism 46.18 9.59 489 160448 106635 56024495
Delusion 45.82 9.59 100 160837 11115 56120015
Hallucination 45.61 9.59 268 160669 48881 56082249
Drug withdrawal syndrome 45.52 9.59 170 160767 25687 56105443
Nasopharyngitis 45.51 9.59 408 160529 220551 55910579
Confusional state 45.16 9.59 841 160096 207314 55923816
Lip ulceration 43.80 9.59 39 160898 1834 56129296
Deep vein thrombosis 42.90 9.59 371 160566 76606 56054524
Bruxism 42.81 9.59 49 160888 3117 56128013
Sinus bradycardia 42.33 9.59 109 160828 13477 56117653
Foetal exposure during pregnancy 42.08 9.59 200 160737 33623 56097507
Congenital absence of vertebra 41.79 9.59 12 160925 36 56131094
Red blood cell sedimentation rate abnormal 41.76 9.59 3 160934 18670 56112460
Abnormal dreams 41.68 9.59 88 160849 9561 56121569
Pyrexia 41.55 9.59 897 160040 417876 55713254
Musculoskeletal stiffness 41.10 9.59 269 160668 155738 55975392
Anger 40.96 9.59 98 160839 11574 56119556
Affective disorder 40.67 9.59 64 160873 5539 56125591
Memory impairment 40.58 9.59 402 160535 86155 56044975
Muscle twitching 40.38 9.59 120 160817 16122 56115008
Arthritis 39.65 9.59 149 160788 99703 56031427
Syncope 38.57 9.59 476 160461 107723 56023407
Osteoporosis 38.11 9.59 56 160881 51996 56079134
Pyramidal tract syndrome 37.68 9.59 19 160918 336 56130794
Psychomotor retardation 37.03 9.59 49 160888 3620 56127510
Nightmare 36.90 9.59 119 160818 16707 56114423
Mental status changes 36.43 9.59 207 160730 37294 56093836
Cardiac arrest 36.26 9.59 392 160545 85922 56045208
Dystonia 36.00 9.59 97 160840 12324 56118806
Clonus 35.77 9.59 52 160885 4197 56126933
Anhedonia 35.61 9.59 84 160853 9830 56121300
Depressive symptom 35.29 9.59 47 160890 3494 56127636
Tachycardia 35.28 9.59 460 160477 105416 56025714
Adjustment disorder with mixed anxiety and depressed mood 34.90 9.59 12 160925 74 56131056
Hostility 34.85 9.59 34 160903 1797 56129333
Bundle branch block left 34.71 9.59 64 160873 6298 56124832
Acute kidney injury 34.00 9.59 484 160453 240279 55890851
Neutropenia 33.90 9.59 289 160648 157878 55973252
Small for dates baby 33.87 9.59 46 160891 3484 56127646
Major depression 33.73 9.59 70 160867 7514 56123616
Nausea 33.59 9.59 2576 158361 761602 55369528
Self-injurious ideation 32.85 9.59 37 160900 2313 56128817
Libido increased 32.04 9.59 28 160909 1284 56129846
Slow speech 31.76 9.59 28 160909 1299 56129831
Generalised tonic-clonic seizure 31.43 9.59 159 160778 27407 56103723
Subdural hygroma 31.32 9.59 15 160922 236 56130894
Pneumocystis jirovecii pneumonia 31.22 9.59 4 160933 15697 56115433
Disorientation 31.02 9.59 195 160742 36418 56094712
Psoriatic arthropathy 30.99 9.59 108 160829 73900 56057230
Respiratory arrest 30.38 9.59 170 160767 30455 56100675
Derealisation 30.36 9.59 25 160912 1056 56130074
Activation syndrome 30.31 9.59 14 160923 202 56130928
Fibromyalgia 29.94 9.59 80 160857 59523 56071607
Optic nerve injury 29.73 9.59 19 160918 537 56130593
Treatment noncompliance 29.69 9.59 177 160760 32446 56098684
Alcoholism 29.55 9.59 34 160903 2175 56128955
Homicidal ideation 29.35 9.59 30 160907 1678 56129452
Bradyphrenia 29.32 9.59 61 160876 6559 56124571
Obsessive-compulsive disorder 29.25 9.59 44 160893 3662 56127468
Skin ulcer 28.79 9.59 41 160896 38567 56092563
Adverse drug reaction 28.67 9.59 93 160844 65039 56066091
Gestational diabetes 28.61 9.59 68 160869 7996 56123134
Cerebral haematoma 28.46 9.59 41 160896 3282 56127848
Congenital pulmonary valve atresia 28.26 9.59 10 160927 68 56131062
Head injury 28.17 9.59 144 160793 24922 56106208
Disease progression 27.86 9.59 181 160756 104992 56026138
Hypersomnia 27.58 9.59 106 160831 16235 56114895
Sight disability 27.31 9.59 11 160926 111 56131019
Intentional product use issue 27.26 9.59 170 160767 99563 56031567
Thermohypoaesthesia 27.23 9.59 11 160926 112 56131018
Product administered to patient of inappropriate age 27.16 9.59 37 160900 2811 56128319
Restless legs syndrome 27.03 9.59 108 160829 16839 56114291
Rheumatoid nodule 26.78 9.59 5 160932 14852 56116278
Conversion disorder 26.76 9.59 28 160909 1610 56129520
Screaming 26.62 9.59 38 160899 3016 56128114
Euphoric mood 26.55 9.59 46 160891 4312 56126818
Pancytopenia 26.49 9.59 147 160790 88568 56042562
Cytomegalovirus infection 26.44 9.59 11 160926 19285 56111845
Multiple organ dysfunction syndrome 26.37 9.59 71 160866 52699 56078431
Angle closure glaucoma 26.24 9.59 31 160906 2040 56129090
Foot deformity 26.17 9.59 18 160919 23807 56107323
Platelet aggregation inhibition 26.16 9.59 11 160926 125 56131005
Sinus tachycardia 25.97 9.59 130 160807 22314 56108816
Morose 25.90 9.59 8 160929 33 56131097
Mucosal inflammation 25.90 9.59 52 160885 42758 56088372
Osteoarthritis 25.67 9.59 130 160807 80166 56050964
Renal impairment 25.62 9.59 131 160806 80582 56050548
Tongue biting 25.51 9.59 25 160912 1329 56129801
Nervousness 25.50 9.59 156 160781 28859 56102271
Initial insomnia 25.41 9.59 52 160885 5527 56125603
Somnambulism 25.03 9.59 49 160888 5043 56126087
Sexual dysfunction 25.01 9.59 39 160898 3349 56127781
Mental impairment 24.39 9.59 86 160851 12636 56118494
Gun shot wound 24.31 9.59 10 160927 107 56131023
Bone marrow failure 24.26 9.59 27 160910 28259 56102871
Gastroschisis 24.21 9.59 13 160924 263 56130867
Bradycardia 24.06 9.59 297 160640 67207 56063923
Behaviour disorder 24.01 9.59 34 160903 2679 56128451
Maternal drugs affecting foetus 23.82 9.59 48 160889 5045 56126085
Dysarthria 23.82 9.59 194 160743 39356 56091774
Bipolar disorder 23.81 9.59 61 160876 7519 56123611
Gastrointestinal disorder 23.66 9.59 207 160730 112495 56018635
Moaning 23.53 9.59 19 160918 780 56130350
Dyspnoea 23.19 9.59 1423 159514 591154 55539976
Sepsis neonatal 23.16 9.59 15 160922 434 56130696
Ventricular dyskinesia 23.15 9.59 10 160927 122 56131008
Bone erosion 23.14 9.59 7 160930 14967 56116163
Psychiatric symptom 23.07 9.59 46 160891 4798 56126332
Drug screen positive 23.01 9.59 38 160899 3426 56127704
Blood cholesterol increased 22.92 9.59 118 160819 72461 56058669
Yawning 22.80 9.59 21 160916 1032 56130098
Rhabdomyolysis 22.66 9.59 196 160741 40462 56090668
Hepatic function abnormal 22.64 9.59 40 160897 34518 56096612
Large intestine anastomosis 22.64 9.59 7 160930 29 56131101
Libido decreased 22.53 9.59 31 160906 2377 56128753
Bradypnoea 22.44 9.59 36 160901 3167 56127963
Multiple sclerosis 22.27 9.59 146 160791 27656 56103474
Fear 22.19 9.59 93 160844 14815 56116315
Polydipsia 22.18 9.59 36 160901 3199 56127931
Extradural haematoma 22.04 9.59 25 160912 1575 56129555
Myoclonus 21.98 9.59 94 160843 15109 56116021
Immobilisation prolonged 21.91 9.59 9 160928 96 56131034
Pruritus 21.90 9.59 714 160223 315909 55815221
Neutropenic sepsis 21.89 9.59 8 160929 15177 56115953
Bursitis 21.87 9.59 28 160909 27554 56103576
Negative thoughts 21.82 9.59 19 160918 867 56130263
Head banging 21.71 9.59 14 160923 402 56130728
Intermenstrual bleeding 21.50 9.59 56 160881 6971 56124159
Panic reaction 21.49 9.59 39 160898 3791 56127339
Right ventricular dilatation 21.45 9.59 21 160916 1115 56130015
Hyperthermia 21.35 9.59 62 160875 8223 56122907
Bundle branch block right 21.33 9.59 44 160893 4703 56126427
Cardio-respiratory arrest 21.29 9.59 247 160690 55074 56076056
Dermatitis atopic 21.29 9.59 62 160875 8237 56122893
Vertigo 21.16 9.59 244 160693 54328 56076802
Liver injury 21.14 9.59 56 160881 41792 56089338
Wheezing 20.96 9.59 127 160810 74899 56056231
Antiphospholipid antibodies 20.95 9.59 10 160927 156 56130974
Emotional disorder 20.95 9.59 80 160857 12215 56118915
Post-traumatic neck syndrome 20.87 9.59 27 160910 1951 56129179
Dysphoria 20.73 9.59 44 160893 4798 56126332
Paraesthesia 20.71 9.59 504 160433 130010 56001120
Thinking abnormal 20.63 9.59 69 160868 9872 56121258
Hypertension 20.62 9.59 536 160401 243742 55887388
Drowning 20.54 9.59 14 160923 442 56130688
Postictal state 20.46 9.59 19 160918 944 56130186
Unresponsive to stimuli 20.41 9.59 158 160779 31567 56099563
Disseminated intravascular coagulation 20.33 9.59 13 160924 17872 56113258
Pain in extremity 20.27 9.59 672 160265 296759 55834371
Red blood cell sedimentation rate increased 20.07 9.59 47 160890 36576 56094554
Band sensation 20.01 9.59 17 160920 750 56130380
Therapeutic product effect incomplete 20.00 9.59 200 160737 105831 56025299
Concussion 19.63 9.59 60 160877 8186 56122944
Tinnitus 19.54 9.59 150 160787 29892 56101238
Hypervigilance 19.53 9.59 12 160925 316 56130814
Platelet count decreased 19.51 9.59 202 160735 106181 56024949
Serum serotonin 19.44 9.59 4 160933 0 56131130
Bipolar I disorder 19.30 9.59 24 160913 1666 56129464
Partner stress 19.23 9.59 12 160925 325 56130805
Cardiogenic shock 19.20 9.59 95 160842 16230 56114900
Tracheal atresia 19.19 9.59 6 160931 26 56131104
Rectal ulcer 19.17 9.59 20 160917 1146 56129984
Upper-airway cough syndrome 19.13 9.59 65 160872 9373 56121757
Poisoning 19.13 9.59 80 160857 12733 56118397
Retinal ischaemia 19.07 9.59 12 160925 330 56130800
Hypertensive cardiomyopathy 19.05 9.59 10 160927 193 56130937
Breast swelling 19.00 9.59 20 160917 1158 56129972
Vision blurred 18.96 9.59 338 160599 82605 56048525
Musculoskeletal pain 18.88 9.59 145 160792 81007 56050123
Hepatitis chronic active 18.80 9.59 7 160930 56 56131074
Blood lactic acid 18.71 9.59 8 160929 95 56131035
Parkinsonism 18.70 9.59 65 160872 9481 56121649
Learning disorder 18.70 9.59 15 160922 610 56130520
Feeling jittery 18.60 9.59 76 160861 11970 56119160
Retroplacental haematoma 18.54 9.59 9 160928 146 56130984
Cardiac failure 18.48 9.59 148 160789 81945 56049185
Panniculitis 18.42 9.59 3 160934 9839 56121291
Eosinophil count increased 18.35 9.59 65 160872 9572 56121558
Hyperventilation 18.31 9.59 46 160891 5602 56125528
Oral candidiasis 18.29 9.59 16 160921 18747 56112383
Biliary dyskinesia 18.22 9.59 29 160908 2534 56128596
Atrioventricular block 18.19 9.59 52 160885 6835 56124295
Heavy menstrual bleeding 18.13 9.59 93 160844 16116 56115014
Amaurosis 18.09 9.59 14 160923 540 56130590
Road traffic accident 17.92 9.59 139 160798 27788 56103342
Balance disorder 17.91 9.59 313 160624 76207 56054923
Caesarean section 17.77 9.59 92 160845 15999 56115131
Lethargy 17.76 9.59 225 160712 51216 56079914
Alcohol abuse 17.76 9.59 25 160912 1959 56129171
Psychomotor skills impaired 17.74 9.59 26 160911 2114 56129016
Blood prolactin increased 17.69 9.59 33 160904 3276 56127854
Ocular hypertension 17.66 9.59 17 160920 884 56130246
Multiple allergies 17.64 9.59 68 160869 10428 56120702
Middle insomnia 17.64 9.59 70 160867 10880 56120250
Feeling of despair 17.62 9.59 26 160911 2127 56129003
Epilepsy 17.55 9.59 128 160809 25103 56106027
Acute myocardial infarction 17.47 9.59 38 160899 30355 56100775
Cytotoxic oedema 17.36 9.59 9 160928 169 56130961
Hyperdynamic left ventricle 17.36 9.59 9 160928 169 56130961
Cerebral thrombosis 17.24 9.59 22 160915 1568 56129562
Drug resistance 17.19 9.59 20 160917 20522 56110608
Hyperphagia 17.17 9.59 22 160915 1574 56129556
Uterine perforation 17.07 9.59 49 160888 6456 56124674
Decreased interest 17.07 9.59 31 160906 3015 56128115
Pneumonia 17.06 9.59 971 159966 406127 55725003
Gallbladder disorder 17.04 9.59 96 160841 17238 56113892
Left ventricle outflow tract obstruction 17.03 9.59 10 160927 242 56130888
Tearfulness 17.02 9.59 35 160902 3733 56127397
Substance abuse 16.98 9.59 39 160898 4486 56126644
Barotrauma 16.95 9.59 9 160928 178 56130952
Haemoglobin urine 16.93 9.59 8 160929 122 56131008
Victim of sexual abuse 16.89 9.59 14 160923 597 56130533
General physical health deterioration 16.84 9.59 364 160573 169646 55961484
Brain injury 16.80 9.59 48 160889 6307 56124823
Trunk injury 16.72 9.59 5 160932 18 56131112
Impulsive behaviour 16.57 9.59 21 160916 1486 56129644
Blood creatinine increased 16.51 9.59 148 160789 80043 56051087
Orgasm abnormal 16.46 9.59 7 160930 82 56131048
Malignant neoplasm progression 16.41 9.59 133 160804 73454 56057676
Magnetic resonance imaging head abnormal 16.33 9.59 23 160914 1803 56129327
Product substitution error 16.31 9.59 5 160932 20 56131110
Macular degeneration 16.27 9.59 18 160919 18890 56112240
Hepatitis infectious mononucleosis 16.23 9.59 7 160930 85 56131045
Drug dependence 16.07 9.59 115 160822 22418 56108712
Ventricular fibrillation 16.05 9.59 68 160869 10884 56120246
Exercise lack of 16.03 9.59 11 160926 351 56130779
Femur fracture 16.01 9.59 58 160879 39237 56091893
Adverse event 15.86 9.59 93 160844 55283 56075847
Cogwheel rigidity 15.84 9.59 23 160914 1854 56129276
Soft tissue injury 15.59 9.59 21 160916 1578 56129552
Hypocoagulable state 15.55 9.59 17 160920 1028 56130102
Persecutory delusion 15.49 9.59 27 160910 2543 56128587
Septic shock 15.45 9.59 106 160831 60729 56070401
Dissociation 15.37 9.59 27 160910 2558 56128572
Tonsillitis 15.36 9.59 41 160896 5179 56125951
Swollen tongue 15.27 9.59 143 160794 30181 56100949
Interstitial lung disease 15.21 9.59 98 160839 56965 56074165
Disinhibition 15.17 9.59 15 160922 806 56130324
Congenital diaphragmatic eventration 15.07 9.59 4 160933 8 56131122
Anti-actin antibody positive 15.07 9.59 4 160933 8 56131122
Mixed anxiety and depressive disorder 14.92 9.59 9 160928 229 56130901
Self-medication 14.82 9.59 26 160911 2461 56128669
Stoma obstruction 14.74 9.59 7 160930 108 56131022
Transplant rejection 14.72 9.59 5 160932 9929 56121201
Creatinine renal clearance decreased 14.70 9.59 12 160925 14547 56116583
Neutrophil count decreased 14.62 9.59 83 160854 49739 56081391
Respiratory disorder 14.59 9.59 49 160888 33908 56097222
Drug metabolite level high 14.58 9.59 3 160934 0 56131130
Obsessive thoughts 14.55 9.59 12 160925 508 56130622
Alcohol use 14.52 9.59 23 160914 2002 56129128
Sleep disorder 14.51 9.59 273 160664 67390 56063740
Haemorrhagic stroke 14.47 9.59 41 160896 5362 56125768
Hypokalaemia 14.47 9.59 363 160574 94074 56037056
Osteonecrosis of jaw 14.42 9.59 48 160889 33310 56097820
Asthma 14.42 9.59 231 160706 112539 56018591
Prothrombin level increased 14.41 9.59 9 160928 244 56130886
Cardiac hypertrophy 14.27 9.59 16 160921 995 56130135
Mood swings 14.06 9.59 89 160848 16658 56114472
Convulsive threshold lowered 14.05 9.59 10 160927 339 56130791
Orthostatic hypotension 14.03 9.59 151 160786 33048 56098082
Carcinoid syndrome 14.02 9.59 7 160930 121 56131009
Spinal cord oedema 14.02 9.59 7 160930 121 56131009
Haemophagocytic lymphohistiocytosis 13.87 9.59 5 160932 9567 56121563
Extensor plantar response 13.87 9.59 17 160920 1163 56129967
Attention-seeking behaviour 13.83 9.59 6 160931 74 56131056
Torticollis 13.83 9.59 21 160916 1762 56129368
Hemianopia 13.83 9.59 16 160921 1030 56130100
Dissociative disorder 13.76 9.59 9 160928 265 56130865
Feeling hot 13.68 9.59 181 160756 41606 56089524
Focal dyscognitive seizures 13.66 9.59 27 160910 2798 56128332
Staring 13.59 9.59 19 160918 1479 56129651
Snoring 13.58 9.59 31 160906 3550 56127580
Fracture 13.57 9.59 19 160918 17999 56113131
Pulmonary fibrosis 13.44 9.59 42 160895 29716 56101414
Neonatal tachycardia 13.25 9.59 4 160933 15 56131115
Transposition of the great vessels 13.25 9.59 8 160929 204 56130926
Pupil fixed 13.24 9.59 20 160917 1670 56129460
Suspected suicide 13.22 9.59 40 160897 5426 56125704
Compulsions 13.18 9.59 8 160929 206 56130924
Bradykinesia 13.16 9.59 37 160900 4817 56126313
Post concussion syndrome 13.15 9.59 11 160926 475 56130655
Cerebellar syndrome 13.14 9.59 30 160907 3437 56127693
Colour blindness 13.12 9.59 9 160928 287 56130843
Apnoea 13.07 9.59 48 160889 7194 56123936
Bundle branch block 13.06 9.59 14 160923 828 56130302
Stoma site discharge 13.05 9.59 18 160919 1384 56129746
Flight of ideas 12.94 9.59 10 160927 385 56130745
Hypomania 12.94 9.59 37 160900 4865 56126265
Joint hyperextension 12.93 9.59 9 160928 294 56130836
Superior sagittal sinus thrombosis 12.91 9.59 13 160924 714 56130416
Neonatal anuria 12.82 9.59 5 160932 46 56131084
Narrow anterior chamber angle 12.82 9.59 5 160932 46 56131084
Haematotoxicity 12.81 9.59 4 160933 8379 56122751
Illusion 12.80 9.59 15 160922 979 56130151
Nuchal rigidity 12.79 9.59 12 160925 604 56130526
Sebaceous gland infection 12.72 9.59 7 160930 149 56130981
Sedation 12.70 9.59 154 160783 34700 56096430
Pulmonary contusion 12.67 9.59 4 160933 18 56131112
Sternal fracture 12.65 9.59 22 160915 2068 56129062
Lip dry 12.64 9.59 6 160931 9734 56121396
Weight increased 12.56 9.59 789 160148 228914 55902216
Metamyelocyte count increased 12.52 9.59 8 160929 226 56130904
Wrong product procured 12.51 9.59 3 160934 3 56131127
Cerebral arteriovenous malformation haemorrhagic 12.51 9.59 3 160934 3 56131127
Mood altered 12.50 9.59 73 160864 13282 56117848
Essential tremor 12.45 9.59 15 160922 1008 56130122
Colitis microscopic 12.41 9.59 50 160887 7825 56123305
Diplopia 12.31 9.59 100 160837 20269 56110861
Poor quality sleep 12.31 9.59 90 160847 17665 56113465
Social avoidant behaviour 12.31 9.59 26 160911 2826 56128304
Blunted affect 12.27 9.59 8 160929 234 56130896
Multimorbidity 12.27 9.59 11 160926 522 56130608
Anxiety disorder 12.26 9.59 31 160906 3789 56127341
Psychotic disorder due to a general medical condition 12.24 9.59 8 160929 235 56130895
Aphasia 12.24 9.59 137 160800 30278 56100852
Exposure via breast milk 12.20 9.59 20 160917 1792 56129338
Hypotension 12.19 9.59 852 160085 249656 55881474
Therapeutic response unexpected 12.16 9.59 87 160850 16957 56114173
Coma scale abnormal 12.16 9.59 36 160901 4827 56126303
Mucosal ulceration 12.15 9.59 14 160923 897 56130233
Sputum culture 12.12 9.59 7 160930 164 56130966
Blood pressure diastolic decreased 12.09 9.59 23 160914 19300 56111830
Anterograde amnesia 12.07 9.59 11 160926 533 56130597
Constricted affect 12.05 9.59 3 160934 4 56131126
Retching 12.05 9.59 73 160864 13457 56117673
Logorrhoea 12.01 9.59 23 160914 2329 56128801
Gambling disorder 11.95 9.59 16 160921 1195 56129935
Flat affect 11.95 9.59 17 160920 1345 56129785
Myocardial infarction 11.95 9.59 190 160747 92680 56038450
Impaired driving ability 11.88 9.59 32 160905 4064 56127066
Holoprosencephaly 11.87 9.59 4 160933 23 56131107
Sleep-related eating disorder 11.82 9.59 13 160924 791 56130339
Ovarian vein thrombosis 11.80 9.59 5 160932 58 56131072
Sleep talking 11.71 9.59 14 160923 933 56130197
Acute myeloid leukaemia 11.71 9.59 19 160918 16953 56114177
Neuromyelitis optica spectrum disorder 11.69 9.59 15 160922 1075 56130055
Laryngectomy 11.59 9.59 4 160933 25 56131105
Cellulitis 11.52 9.59 148 160789 74801 56056329
Enterococcus test positive 11.52 9.59 15 160922 1091 56130039
Creatinine urine decreased 11.51 9.59 7 160930 181 56130949
Skin necrosis 11.50 9.59 11 160926 12350 56118780
Gastrointestinal procedural complication 11.47 9.59 7 160930 182 56130948
Haematoma 11.46 9.59 141 160796 31878 56099252
Choroidal effusion 11.45 9.59 10 160927 458 56130672
Migraine 11.40 9.59 327 160610 86470 56044660
Pulseless electrical activity 11.39 9.59 45 160892 6979 56124151
Tonic clonic movements 11.36 9.59 16 160921 1254 56129876
Atrophy of globe 11.30 9.59 3 160934 6 56131124
Wound healing normal 11.30 9.59 3 160934 6 56131124
Meningocele 11.30 9.59 3 160934 6 56131124
Respiratory tract infection 11.29 9.59 155 160782 35916 56095214
Neonatal respiratory depression 11.29 9.59 5 160932 65 56131065
Cyanosis neonatal 11.24 9.59 8 160929 271 56130859
Tachyphrenia 11.23 9.59 16 160921 1268 56129862
Hypernatraemia 11.22 9.59 43 160894 6577 56124553
Anaemia 11.20 9.59 638 160299 266873 55864257
Antipsychotic drug level increased 11.14 9.59 27 160910 3215 56127915
Compulsive shopping 11.12 9.59 12 160925 715 56130415
Cor pulmonale acute 11.12 9.59 9 160928 371 56130759
Dry mouth 11.12 9.59 251 160686 63954 56067176
Cyclic vomiting syndrome 11.09 9.59 5 160932 68 56131062
Dextrocardia 11.08 9.59 4 160933 29 56131101
Headache 11.07 9.59 1789 159148 557255 55573875
Stress 11.06 9.59 233 160704 58677 56072453
Incoherent 11.05 9.59 32 160905 4237 56126893
Lung diffusion disorder 10.96 9.59 5 160932 70 56131060
Impaired gastric emptying 10.96 9.59 54 160883 9209 56121921
Periorbital haemorrhage 10.90 9.59 5 160932 71 56131059
Menometrorrhagia 10.89 9.59 13 160924 865 56130265
Bile acid malabsorption 10.89 9.59 7 160930 200 56130930
Subdural haematoma 10.88 9.59 71 160866 13428 56117702
Cluster headache 10.75 9.59 11 160926 616 56130514
Oedema 10.74 9.59 167 160770 81753 56049377
CSF pressure increased 10.73 9.59 6 160931 132 56130998
Metastases to bone 10.72 9.59 25 160912 19483 56111647
Mitochondrial myopathy 10.59 9.59 5 160932 76 56131054
Electrocardiogram P wave abnormal 10.58 9.59 7 160930 210 56130920
Bone swelling 10.58 9.59 17 160920 1498 56129632
Hypotonia 10.57 9.59 51 160886 8626 56122504
Peripheral venous disease 10.57 9.59 8 160929 10071 56121059
Coordination abnormal 10.55 9.59 67 160870 12554 56118576
Catatonia 10.54 9.59 30 160907 3934 56127196
White blood cell count decreased 10.47 9.59 277 160660 125713 56005417
Apallic syndrome 10.45 9.59 11 160926 637 56130493
Ejection fraction decreased 10.45 9.59 26 160911 19815 56111315
Optic atrophy 10.41 9.59 15 160922 1201 56129929
Polyarthritis 10.40 9.59 6 160931 8722 56122408
Bronchial hyperreactivity 10.39 9.59 17 160920 1520 56129610
Sialoadenitis 10.39 9.59 17 160920 1521 56129609
Oesophageal atresia 10.39 9.59 10 160927 520 56130610
Amenorrhoea 10.36 9.59 52 160885 8934 56122196
Pancreatic carcinoma recurrent 10.31 9.59 5 160932 81 56131049
Finger deformity 10.30 9.59 3 160934 6574 56124556
Biliary colic 10.30 9.59 27 160910 3375 56127755
Housebound 10.27 9.59 7 160930 221 56130909
Endometrial disorder 10.24 9.59 11 160926 652 56130478
Congenital tracheomalacia 10.24 9.59 4 160933 37 56131093
Sluggishness 10.22 9.59 33 160904 4635 56126495
Convulsions local 10.21 9.59 3 160934 10 56131120
Fatigue 10.18 9.59 2045 158892 786507 55344623
Head titubation 10.17 9.59 12 160925 789 56130341
Speech disorder 10.12 9.59 157 160780 37336 56093794
Belligerence 10.11 9.59 6 160931 148 56130982
Live birth 10.08 9.59 26 160911 19579 56111551
Urinary incontinence 10.04 9.59 129 160808 29456 56101674
Device placement issue 10.02 9.59 13 160924 942 56130188
Tic 9.90 9.59 15 160922 1256 56129874
Movement disorder 9.90 9.59 91 160846 19107 56112023
Sputum discoloured 9.86 9.59 16 160921 14276 56116854
Anorgasmia 9.85 9.59 10 160927 555 56130575
Hot flush 9.83 9.59 188 160749 46538 56084592
Basilar migraine 9.79 9.59 4 160933 42 56131088
Neoplasm malignant 9.71 9.59 42 160895 27013 56104117
Angina pectoris 9.69 9.59 44 160893 27932 56103198
Electrocardiogram U wave present 9.69 9.59 5 160932 93 56131037
Gallbladder injury 9.65 9.59 15 160922 1285 56129845
Hepatotoxicity 9.64 9.59 51 160886 31102 56100028
Emotional poverty 9.63 9.59 8 160929 342 56130788
Inappropriate affect 9.61 9.59 12 160925 837 56130293
Pneumoconiosis 9.60 9.59 3 160934 13 56131117
Pulmonary arterial hypertension 9.60 9.59 41 160896 26462 56104668

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 432.58 10.32 352 72049 18421 31606522
Completed suicide 301.23 10.32 653 71748 90861 31534082
Suicidal ideation 301.19 10.32 393 72008 36013 31588930
Suicide attempt 269.89 10.32 377 72024 36871 31588072
Intentional overdose 242.35 10.32 379 72022 41010 31583933
Depression 228.91 10.32 584 71817 90231 31534712
Anxiety 213.65 10.32 570 71831 90463 31534480
Agitation 191.26 10.32 398 72003 53771 31571172
Aggression 145.88 10.32 286 72115 37005 31587938
Somnolence 135.94 10.32 517 71884 98928 31526015
Intentional self-injury 129.58 10.32 156 72245 13159 31611784
Tremor 121.11 10.32 417 71984 76003 31548940
Foetal exposure during pregnancy 115.66 10.32 275 72126 40601 31584342
Sopor 102.18 10.32 129 72272 11423 31613520
Overdose 97.93 10.32 418 71983 84246 31540697
Withdrawal syndrome 96.04 10.32 126 72275 11591 31613352
Electrocardiogram QT prolonged 93.16 10.32 242 72159 37745 31587198
Paranoia 91.98 10.32 117 72284 10438 31614505
Mania 91.72 10.32 109 72292 9068 31615875
Poisoning deliberate 88.29 10.32 96 72305 7248 31617695
Intrusive thoughts 84.96 10.32 30 72371 261 31624682
Sexual dysfunction 84.24 10.32 85 72316 5883 31619060
Drug interaction 82.65 10.32 782 71619 207761 31417182
Disturbance in attention 80.37 10.32 166 72235 22284 31602659
Major depression 77.98 10.32 70 72331 4183 31620760
Febrile neutropenia 74.15 10.32 102 72299 121747 31503196
Sedation 73.57 10.32 145 72256 18820 31606123
Insomnia 73.01 10.32 417 71984 94419 31530524
Muscle rigidity 68.39 10.32 98 72303 9799 31615144
Coma 68.16 10.32 228 72173 40922 31584021
Maternal drugs affecting foetus 67.18 10.32 62 72339 3841 31621102
Loss of libido 66.12 10.32 50 72351 2345 31622598
Confusional state 65.23 10.32 524 71877 132810 31492133
Drug withdrawal syndrome 65.19 10.32 137 72264 18613 31606330
Fall 65.02 10.32 680 71721 185409 31439534
Irritability 64.72 10.32 154 72247 22735 31602208
Restlessness 63.72 10.32 155 72246 23206 31601737
Dyskinesia 62.74 10.32 144 72257 20766 31604177
Anger 60.90 10.32 99 72302 11054 31613889
Panic attack 56.97 10.32 84 72317 8619 31616324
Activation syndrome 56.67 10.32 17 72384 82 31624861
Tachyphrenia 56.44 10.32 35 72366 1182 31623761
Erectile dysfunction 56.10 10.32 131 72270 19104 31605839
Interstitial lung disease 55.37 10.32 36 72365 61367 31563576
Thrombocytopenia 53.78 10.32 158 72243 142589 31482354
Pyrexia 53.49 10.32 441 71960 303399 31321544
Hyperhidrosis 52.93 10.32 298 72103 67095 31557848
Septic shock 52.90 10.32 44 72357 66114 31558829
Neutropenia 52.42 10.32 156 72245 140208 31484735
Apathy 52.02 10.32 69 72332 6413 31618530
Mood swings 52.01 10.32 74 72327 7350 31617593
Rheumatoid arthritis 52.01 10.32 22 72379 47787 31577156
Hypomania 51.63 10.32 42 72359 2193 31622750
Mycotic allergy 50.84 10.32 22 72379 343 31624600
Product substitution issue 50.52 10.32 83 72318 9349 31615594
Pneumonia 50.21 10.32 507 71894 334805 31290138
Homicidal ideation 50.20 10.32 44 72357 2547 31622396
Libido decreased 49.89 10.32 56 72345 4380 31620563
Hallucination 49.69 10.32 224 72177 46186 31578757
Akathisia 48.91 10.32 71 72330 7182 31617761
Renal impairment 48.86 10.32 76 72325 86273 31538670
Mite allergy 47.73 10.32 22 72379 401 31624542
Hallucination, visual 47.64 10.32 109 72292 15685 31609258
Anorgasmia 46.76 10.32 26 72375 714 31624229
Drug withdrawal syndrome neonatal 46.14 10.32 48 72353 3444 31621499
Sepsis 45.84 10.32 185 72216 151744 31473199
Bipolar disorder 45.32 10.32 49 72352 3675 31621268
Spirometry abnormal 45.30 10.32 22 72379 453 31624490
Gun shot wound 44.60 10.32 29 72372 1065 31623878
Hallucination, auditory 43.60 10.32 82 72319 10278 31614665
Tardive dyskinesia 42.82 10.32 58 72343 5501 31619442
Abulia 42.70 10.32 22 72379 516 31624427
Parkinsonism 41.98 10.32 68 72333 7568 31617375
Mydriasis 41.11 10.32 62 72339 6490 31618453
Chest injury 41.04 10.32 31 72370 1451 31623492
Sleep disorder 40.99 10.32 143 72258 26205 31598738
Dust allergy 40.83 10.32 22 72379 567 31624376
Respiratory disorder neonatal 40.80 10.32 31 72370 1464 31623479
Malignant neoplasm progression 40.56 10.32 74 72327 78924 31546019
Multiple organ dysfunction syndrome 40.55 10.32 58 72343 68145 31556798
Conjunctivitis allergic 40.54 10.32 24 72377 744 31624199
Depressed mood 40.06 10.32 109 72292 17466 31607477
Renal failure 39.87 10.32 146 72255 123184 31501759
Catatonia 39.80 10.32 52 72349 4762 31620181
Hyperreflexia 39.80 10.32 41 72360 2908 31622035
Infusion related reaction 39.61 10.32 31 72370 48024 31576919
Amnesia 39.03 10.32 130 72271 23272 31601671
Acute kidney injury 38.94 10.32 430 71971 279284 31345659
Neuroleptic malignant syndrome 38.82 10.32 105 72296 16764 31608179
Memory impairment 38.56 10.32 181 72220 37949 31586994
Anaemia 37.91 10.32 309 72092 213213 31411730
Abnormal behaviour 35.93 10.32 128 72273 23700 31601243
Foetal malformation 35.67 10.32 13 72388 125 31624818
Alcoholism 35 10.32 41 72360 3358 31621585
Impulsive behaviour 34.69 10.32 32 72369 1981 31622962
Homicide 33.87 10.32 23 72378 909 31624034
Social avoidant behaviour 33.82 10.32 38 72363 2975 31621968
Bone marrow failure 33.63 10.32 11 72390 27997 31596946
Myoclonus 33.12 10.32 88 72313 13902 31611041
Resting tremor 33.05 10.32 20 72381 646 31624297
Extrapyramidal disorder 33.02 10.32 79 72322 11699 31613244
Feeling abnormal 32.87 10.32 233 72168 56769 31568174
Small for dates baby 32.61 10.32 41 72360 3614 31621329
Clonus 32.16 10.32 34 72367 2485 31622458
Electrocardiogram QT interval 31.97 10.32 9 72392 33 31624910
Anencephaly 31.91 10.32 12 72389 127 31624816
Psychotic disorder 31.28 10.32 117 72284 22176 31602767
Painful respiration 30.96 10.32 24 72377 1168 31623775
Seizure 30.81 10.32 356 72045 99412 31525531
Skin dystrophy 30.75 10.32 7 72394 7 31624936
Walking aid user 30.14 10.32 27 72374 1609 31623334
Delusion 29.97 10.32 77 72324 11920 31613023
Depressive symptom 29.63 10.32 30 72371 2084 31622859
Loss of consciousness 29.48 10.32 288 72113 77067 31547876
Electrocardiogram QRS complex prolonged 29.40 10.32 42 72359 4187 31620756
Postural orthostatic tachycardia syndrome 29.10 10.32 9 72392 49 31624894
Reduced facial expression 28.72 10.32 20 72381 824 31624119
Persecutory delusion 28.71 10.32 31 72370 2321 31622622
Lactic acidosis 28.41 10.32 19 72382 31918 31593025
Prescribed overdose 28.34 10.32 64 72337 9128 31615815
Cardiac failure 28.26 10.32 101 72300 85852 31539091
Cerebral haematoma 28.16 10.32 42 72359 4353 31620590
Consciousness fluctuating 28.06 10.32 22 72379 1089 31623854
Drug screen positive 27.88 10.32 39 72362 3813 31621130
Blood creatinine increased 27.77 10.32 107 72294 88971 31535972
Dyspnoea 27.54 10.32 587 71814 342892 31282051
Congenital ureteropelvic junction obstruction 27.44 10.32 9 72392 61 31624882
Alcohol use 27.42 10.32 35 72366 3132 31621811
Cogwheel rigidity 27.06 10.32 23 72378 1277 31623666
Craniosynostosis 27.00 10.32 14 72387 333 31624610
Device dislocation 26.98 10.32 45 72356 5131 31619812
Psychomotor hyperactivity 26.89 10.32 61 72340 8726 31616217
Self esteem decreased 26.88 10.32 16 72385 501 31624442
Hyperthermia 26.87 10.32 66 72335 9938 31615005
Off label use 26.83 10.32 597 71804 346677 31278266
Emotional disorder 26.52 10.32 45 72356 5204 31619739
Cognitive disorder 26.44 10.32 120 72281 24803 31600140
Reversible cerebral vasoconstriction syndrome 26.44 10.32 14 72387 348 31624595
Disorientation 26.16 10.32 139 72262 30605 31594338
Delirium 26.06 10.32 173 72228 41248 31583695
Trisomy 18 25.97 10.32 14 72387 361 31624582
Platelet count decreased 25.95 10.32 147 72254 110288 31514655
Psychomotor retardation 25.15 10.32 34 72367 3218 31621725
Mental disorder 25.00 10.32 79 72322 13755 31611188
Infantile apnoea 24.68 10.32 19 72382 915 31624028
Bruxism 24.45 10.32 24 72377 1606 31623337
Poor quality sleep 24.28 10.32 54 72347 7624 31617319
Depressed level of consciousness 24.15 10.32 161 72240 38440 31586503
Libido increased 24.02 10.32 17 72384 719 31624224
Urinary retention 23.78 10.32 145 72256 33580 31591363
Torsade de pointes 23.74 10.32 50 72351 6800 31618143
Apraxia 23.53 10.32 21 72380 1245 31623698
Bradypnoea 23.41 10.32 29 72372 2518 31622425
Anhedonia 23.15 10.32 52 72349 7390 31617553
Cardiac failure congestive 23.07 10.32 98 72303 79289 31545654
Gambling disorder 22.94 10.32 23 72378 1579 31623364
Derealisation 22.61 10.32 15 72386 570 31624373
Orthostatic hypotension 22.58 10.32 112 72289 24007 31600936
Priapism 22.54 10.32 39 72362 4581 31620362
Toxic encephalopathy 22.44 10.32 40 72361 4810 31620133
Legal problem 22.33 10.32 10 72391 170 31624773
Feeling guilty 22.28 10.32 12 72389 309 31624634
Agitation neonatal 22.21 10.32 19 72382 1064 31623879
Gynaecomastia 22.09 10.32 58 72343 9096 31615847
Inhibitory drug interaction 21.83 10.32 22 72379 1520 31623423
Orgasm abnormal 21.80 10.32 9 72392 124 31624819
Respiratory failure 21.74 10.32 139 72262 101310 31523633
Neonatal pneumonia 21.67 10.32 9 72392 126 31624817
Cytomegalovirus infection 21.57 10.32 15 72386 24692 31600251
Pregnancy 21.51 10.32 11 72390 254 31624689
Hypersomnia 21.49 10.32 65 72336 11054 31613889
Disseminated intravascular coagulation 21.46 10.32 10 72391 20527 31604416
Ascites 21.41 10.32 38 72363 40975 31583968
Negative thoughts 21.41 10.32 15 72386 624 31624319
Total lung capacity abnormal 21.36 10.32 9 72392 131 31624812
Gastrointestinal hypermotility 21.30 10.32 9 72392 132 31624811
Neonatal respiratory distress 21.27 10.32 14 72387 525 31624418
Bronchopulmonary aspergillosis 21.13 10.32 3 72398 13631 31611312
Burnout syndrome 20.82 10.32 9 72392 140 31624803
Crying 20.75 10.32 42 72359 5555 31619388
Obsessive-compulsive disorder 20.67 10.32 39 72362 4898 31620045
Disinhibition 20.59 10.32 28 72373 2665 31622278
Congenital hearing disorder 20.52 10.32 8 72393 94 31624849
Electrocardiogram QT interval abnormal 20.52 10.32 8 72393 94 31624849
Tension 20.38 10.32 24 72377 1977 31622966
Abnormal dreams 20.27 10.32 48 72353 7060 31617883
Rash 20.24 10.32 331 72070 201155 31423788
Stomatitis 20.18 10.32 37 72364 39401 31585542
Judgement impaired 20.05 10.32 14 72387 579 31624364
Pruritus 20.01 10.32 186 72215 124981 31499962
Persistent depressive disorder 19.85 10.32 11 72390 300 31624643
Parkinsonian gait 19.76 10.32 13 72388 487 31624456
Death 19.71 10.32 651 71750 359918 31265025
Ejaculation disorder 19.56 10.32 17 72384 973 31623970
Myelosuppression 19.49 10.32 5 72396 14915 31610028
Muscle necrosis 19.48 10.32 16 72385 847 31624096
Oedema peripheral 19.43 10.32 159 72242 109680 31515263
Poisoning 19.39 10.32 60 72341 10331 31614612
Septum pellucidum agenesis 19.33 10.32 7 72394 66 31624877
Hypoglycaemia neonatal 19.19 10.32 22 72379 1760 31623183
Retrograde amnesia 18.95 10.32 8 72393 117 31624826
Atrial septal defect 18.92 10.32 46 72355 6881 31618062
Plasma cell myeloma 18.86 10.32 66 72335 56465 31568478
Brain stem haematoma 18.77 10.32 8 72393 120 31624823
Inappropriate antidiuretic hormone secretion 18.75 10.32 63 72338 11324 31613619
Bradyphrenia 18.70 10.32 35 72366 4369 31620574
Contraindicated product administered 18.63 10.32 11 72390 19761 31605182
Urticaria 18.62 10.32 68 72333 57449 31567494
Condition aggravated 18.50 10.32 498 71903 163511 31461432
Neutrophil count decreased 18.44 10.32 50 72351 46344 31578599
Bradykinesia 18.42 10.32 31 72370 3561 31621382
Physical deconditioning 18.33 10.32 16 72385 921 31624022
Drug resistance 18.25 10.32 16 72385 23437 31601506
Post-traumatic stress disorder 18.24 10.32 21 72380 1688 31623255
Trisomy 21 18.22 10.32 13 72388 557 31624386
Toxic epidermal necrolysis 18.21 10.32 11 72390 19513 31605430
Infection 18.20 10.32 111 72290 81820 31543123
Physical assault 17.99 10.32 17 72384 1085 31623858
Mental impairment 17.75 10.32 55 72346 9477 31615466
Neonatal seizure 17.72 10.32 12 72389 472 31624471
Congenital pulmonary hypertension 17.65 10.32 6 72395 46 31624897
Pain in extremity 17.59 10.32 175 72226 116028 31508915
Inflammation 17.57 10.32 19 72382 25222 31599721
Reactive psychosis 17.57 10.32 4 72397 4 31624939
Electrocardiogram QT shortened 17.40 10.32 8 72393 145 31624798
Exposure during pregnancy 17.32 10.32 51 72350 8547 31616396
Drug eruption 17.31 10.32 10 72391 18177 31606766
Dysgraphia 17.15 10.32 23 72378 2160 31622783
Pelvic kidney 17.12 10.32 7 72394 94 31624849
Leukopenia 17.04 10.32 71 72330 57757 31567186
Aspergillus infection 16.82 10.32 3 72398 11525 31613418
Behaviour disorder 16.57 10.32 33 72368 4314 31620629
Neuropathy peripheral 16.54 10.32 103 72298 75546 31549397
Panic disorder 16.51 10.32 17 72384 1205 31623738
Neutropenic sepsis 16.46 10.32 4 72397 12375 31612568
Hyperglycaemia 16.30 10.32 37 72364 36439 31588504
Feeling of despair 16.28 10.32 15 72386 927 31624016
Hypertonia 16.19 10.32 31 72370 3937 31621006
Medication error 16.11 10.32 98 72303 22674 31602269
Postictal psychosis 16.07 10.32 8 72393 174 31624769
Pneumocystis jirovecii pneumonia 16.04 10.32 11 72390 18240 31606703
Dementia with Lewy bodies 15.91 10.32 13 72388 683 31624260
Cough 15.76 10.32 215 72186 134599 31490344
Personality disorder 15.69 10.32 16 72385 1121 31623822
Depersonalisation/derealisation disorder 15.66 10.32 12 72389 574 31624369
Nightmare 15.63 10.32 62 72339 12075 31612868
Pancytopenia 15.62 10.32 126 72275 87190 31537753
Congenital hydronephrosis 15.54 10.32 13 72388 706 31624237
Helplessness 15.51 10.32 6 72395 69 31624874
Dissociation 15.51 10.32 17 72384 1295 31623648
Feelings of worthlessness 15.50 10.32 9 72392 269 31624674
Palmar-plantar erythrodysaesthesia syndrome 15.48 10.32 8 72393 15475 31609468
Arthralgia 15.44 10.32 248 72153 151176 31473767
Atrial fibrillation 15.34 10.32 176 72225 113607 31511336
Erythema 15.33 10.32 114 72287 80291 31544652
Tumour lysis syndrome 15.31 10.32 8 72393 15377 31609566
White blood cell count decreased 15.23 10.32 127 72274 87271 31537672
Neonatal hyponatraemia 15.21 10.32 6 72395 73 31624870
Family stress 15.02 10.32 7 72394 131 31624812
Dementia 15.01 10.32 62 72339 12298 31612645
Hypersensitivity 14.88 10.32 71 72330 55672 31569271
Somatic symptom disorder 14.82 10.32 12 72389 622 31624321
Sleep-related eating disorder 14.78 10.32 9 72392 294 31624649
Ejaculation failure 14.75 10.32 13 72388 758 31624185
Chemical submission 14.75 10.32 5 72396 38 31624905
Renal dysplasia 14.75 10.32 8 72393 209 31624734
Graft versus host disease 14.64 10.32 3 72398 10444 31614499
Weight increased 14.45 10.32 268 72133 82679 31542264
Gastrointestinal haemorrhage 14.36 10.32 120 72281 82429 31542514
Personality change 14.35 10.32 33 72368 4762 31620181
Alcohol abuse 14.32 10.32 32 72369 4532 31620411
Joint swelling 14.29 10.32 68 72333 53363 31571580
Swelling 14.29 10.32 41 72360 37317 31587626
Dizziness 14.26 10.32 573 71828 198574 31426369
Sperm concentration decreased 14.24 10.32 7 72394 148 31624795
Thinking abnormal 14.16 10.32 36 72365 5537 31619406
Muscle twitching 13.97 10.32 46 72355 8184 31616759
Head discomfort 13.79 10.32 28 72373 3711 31621232
Hepatotoxicity 13.76 10.32 14 72387 19112 31605831
Sexually inappropriate behaviour 13.60 10.32 10 72391 449 31624494
Illness anxiety disorder 13.44 10.32 7 72394 168 31624775
Rabbit syndrome 13.38 10.32 4 72397 19 31624924
Abnormal clotting factor 13.37 10.32 5 72396 52 31624891
Nasopharyngitis 13.37 10.32 87 72314 63158 31561785
Back pain 13.32 10.32 173 72228 109240 31515703
Male orgasmic disorder 13.29 10.32 6 72395 104 31624839
Renal haemorrhage 13.24 10.32 16 72385 1354 31623589
Myocardial infarction 13.23 10.32 181 72220 113273 31511670
Delusional disorder, erotomanic type 13.18 10.32 3 72398 3 31624940
Rapid eye movements sleep abnormal 13.07 10.32 7 72394 178 31624765
Loss of employment 13.06 10.32 10 72391 478 31624465
Mucosal inflammation 13.01 10.32 38 72363 34389 31590554
Ureteric haemorrhage 12.99 10.32 6 72395 110 31624833
Pneumonitis 12.97 10.32 32 72369 30620 31594323
Human herpesvirus 6 infection 12.97 10.32 19 72382 1938 31623005
Social fear 12.72 10.32 3 72398 4 31624939
Yawning 12.70 10.32 10 72391 498 31624445
Stress 12.69 10.32 99 72302 24842 31600101
Suicidal behaviour 12.67 10.32 16 72385 1416 31623527
Hypokinesia 12.65 10.32 44 72357 8048 31616895
Affective disorder 12.64 10.32 27 72374 3709 31621234
Somnambulism 12.53 10.32 23 72378 2829 31622114
Premature ejaculation 12.47 10.32 6 72395 121 31624822
Feeling jittery 12.43 10.32 27 72374 3750 31621193
Hepatic failure 12.43 10.32 36 72365 32666 31592277
Haemoglobin decreased 12.34 10.32 182 72219 112493 31512450
Hypospadias 12.29 10.32 24 72377 3092 31621851
Chronic kidney disease 12.22 10.32 45 72356 37930 31587013
Venous angioma of brain 12.08 10.32 4 72397 28 31624915
Stress at work 12.03 10.32 7 72394 210 31624733
Acute myeloid leukaemia 11.98 10.32 15 72386 18657 31606286
Multiple drug therapy 11.98 10.32 9 72392 418 31624525
Electrocardiogram abnormal 11.97 10.32 43 72358 7993 31616950
Logorrhoea 11.87 10.32 20 72381 2299 31622644
Selective eating disorder 11.83 10.32 17 72384 1703 31623240
Liver disorder 11.81 10.32 32 72369 29675 31595268
Prostate cancer 11.81 10.32 45 72356 37556 31587387
Grandiosity 11.78 10.32 8 72393 316 31624627
Tearfulness 11.75 10.32 18 72383 1909 31623034
Acute myocardial infarction 11.73 10.32 68 72333 50755 31574188
Haemophagocytic lymphohistiocytosis 11.73 10.32 6 72395 11672 31613271
Carbon dioxide increased 11.69 10.32 13 72388 1006 31623937
Pleural effusion 11.67 10.32 112 72289 74808 31550135
Affect lability 11.67 10.32 25 72376 3440 31621503
Generalised anxiety disorder 11.62 10.32 11 72390 704 31624239
Frustration tolerance decreased 11.56 10.32 20 72381 2348 31622595
Lung neoplasm malignant 11.54 10.32 12 72389 16218 31608725
Prescription form tampering 11.52 10.32 9 72392 443 31624500
Bladder cancer 11.51 10.32 10 72391 14715 31610228
Treatment failure 11.45 10.32 51 72350 40741 31584202
Obsessive-compulsive personality disorder 11.41 10.32 6 72395 147 31624796
Congenital megaureter 11.41 10.32 6 72395 147 31624796
Attention deficit hyperactivity disorder 11.38 10.32 20 72381 2378 31622565
Autoscopy 11.37 10.32 6 72395 148 31624795
Paresis 11.34 10.32 18 72383 1969 31622974
C-reactive protein increased 11.28 10.32 65 72336 48585 31576358
Fluid retention 11.21 10.32 25 72376 24777 31600166
Generalised tonic-clonic seizure 11.21 10.32 81 72320 19850 31605093
Colitis microscopic 11.19 10.32 18 72383 1992 31622951
Suture rupture 11.17 10.32 8 72393 345 31624598
Nephropathy toxic 11.15 10.32 6 72395 11347 31613596
Hyperammonaemic encephalopathy 11.13 10.32 19 72382 2207 31622736
Pulmonary fibrosis 11.10 10.32 13 72388 16647 31608296
Sprue-like enteropathy 11.08 10.32 9 72392 469 31624474
Normochromic normocytic anaemia 11.06 10.32 26 72375 3806 31621137
Mood altered 11.05 10.32 43 72358 8303 31616640
Impaired work ability 11.02 10.32 34 72367 5843 31619100
Theft 10.91 10.32 7 72394 251 31624692
Hypocalcaemia 10.91 10.32 21 72380 21957 31602986
Herpes zoster 10.90 10.32 37 72364 31956 31592987
Anaphylactic reaction 10.89 10.32 33 72368 29520 31595423
Tinnitus 10.86 10.32 69 72332 16206 31608737
Balance disorder 10.85 10.32 132 72269 37290 31587653
Imprisonment 10.83 10.32 9 72392 484 31624459
Exposure via breast milk 10.82 10.32 17 72384 1843 31623100
Sleep disorder due to a general medical condition 10.75 10.32 26 72375 3876 31621067
Telangiectasia 10.74 10.32 11 72390 775 31624168
Neonatal tachypnoea 10.72 10.32 6 72395 167 31624776
Posterior reversible encephalopathy syndrome 10.69 10.32 4 72397 9363 31615580
Urinary incontinence 10.68 10.32 72 72329 17248 31607695
Obsessive thoughts 10.65 10.32 10 72391 633 31624310
Steroid dependence 10.64 10.32 9 72392 496 31624447
Congenital diaphragmatic hernia 10.60 10.32 7 72394 264 31624679
Anaphylactic shock 10.59 10.32 10 72391 14135 31610808
Pulmonary oedema 10.57 10.32 59 72342 44443 31580500
Flat affect 10.54 10.32 11 72390 792 31624151
Tuberculosis 10.51 10.32 3 72398 8338 31616605
Hyponatriuria 10.45 10.32 3 72398 12 31624931
Feminisation acquired 10.42 10.32 4 72397 45 31624898
Renal tubular necrosis 10.40 10.32 11 72390 14748 31610195
Lens dislocation 10.38 10.32 5 72396 101 31624842
Hypervolaemia 10.37 10.32 16 72385 18235 31606708

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 635.51 9.63 658 182687 41456 70703643
Suicide attempt 618.29 9.63 888 182457 78622 70666477
Suicidal ideation 606.40 9.63 821 182524 68775 70676324
Intentional overdose 566.54 9.63 957 182388 97478 70647621
Completed suicide 554.15 9.63 1560 181785 225575 70519524
Anxiety 517.71 9.63 1493 181852 218837 70526262
Depression 508.35 9.63 1390 181955 197584 70547515
Electrocardiogram QT prolonged 433.56 9.63 776 182569 82741 70662358
Sopor 409.01 9.63 453 182892 30814 70714285
Somnolence 329.77 9.63 1264 182081 214342 70530757
Overdose 292.95 9.63 1035 182310 168710 70576389
Drug interaction 260.99 9.63 1783 181562 379658 70365441
Agitation 246.76 9.63 661 182684 92714 70652385
Tremor 242.41 9.63 918 182427 154706 70590393
Rheumatoid arthritis 235.63 9.63 244 183101 291561 70453538
Intentional self-injury 234.94 9.63 346 182999 31304 70713795
Synovitis 222.60 9.63 34 183311 129194 70615905
Pemphigus 198.95 9.63 3 183342 83033 70662066
Coma 194.98 9.63 601 182744 91243 70653856
Hand deformity 182.60 9.63 10 183335 86472 70658627
Contraindicated product administered 179.24 9.63 62 183283 134550 70610549
Withdrawal syndrome 167.43 9.63 260 183085 24644 70720455
Joint swelling 161.49 9.63 253 183092 252958 70492141
Arthropathy 156.68 9.63 97 183248 149960 70595139
Infusion related reaction 155.07 9.63 169 183176 197365 70547734
Product substitution issue 151.47 9.63 212 183133 18301 70726798
Mania 148.53 9.63 202 183143 16972 70728127
Poisoning deliberate 148.06 9.63 201 183144 16859 70728240
Drug intolerance 147.25 9.63 222 183123 225465 70519634
Systemic lupus erythematosus 146.28 9.63 41 183304 101861 70643238
Treatment failure 143.92 9.63 98 183247 144044 70601055
Aggression 139.23 9.63 354 182991 48092 70697007
Fall 137.23 9.63 1751 181594 442345 70302754
Hyponatraemia 136.33 9.63 792 182553 159295 70585804
Inappropriate antidiuretic hormone secretion 135.99 9.63 228 183117 23048 70722051
Febrile neutropenia 132.29 9.63 202 183143 204116 70540983
Akathisia 130.45 9.63 160 183185 12133 70732966
Irritability 129.88 9.63 298 183047 37927 70707172
Paranoia 123.99 9.63 186 183159 17102 70727997
Panic attack 117.85 9.63 208 183137 21911 70723188
Duodenal ulcer perforation 117.81 9.63 3 183342 51109 70693990
Glossodynia 116.56 9.63 39 183306 86448 70658651
Muscle rigidity 116.11 9.63 188 183157 18462 70726637
Helicobacter infection 115.76 9.63 7 183338 55649 70689450
Swelling 113.06 9.63 196 183149 188343 70556756
Torsade de pointes 107.90 9.63 179 183166 17937 70727162
Mydriasis 106.29 9.63 167 183178 15986 70729113
Seizure 102.46 9.63 799 182546 177163 70567936
Disturbance in attention 101.72 9.63 292 183053 42602 70702497
Mental disorder 101.34 9.63 225 183120 28015 70717084
Pericarditis 101.27 9.63 46 183299 84659 70660440
Tardive dyskinesia 97.01 9.63 124 183221 9805 70735294
Wound 96.06 9.63 69 183276 98663 70646436
Hyperhidrosis 95.61 9.63 625 182720 130961 70614138
Insomnia 90.27 9.63 910 182435 216896 70528203
Acute kidney injury 90.09 9.63 789 182556 473835 70271264
Confusional state 89.64 9.63 1126 182219 283272 70461827
Dyskinesia 89.19 9.63 271 183074 40803 70704296
Loss of consciousness 88.44 9.63 697 182648 155019 70590080
Restlessness 86.88 9.63 273 183072 41855 70703244
Crying 85.37 9.63 177 183168 21022 70724077
Apathy 85.22 9.63 128 183217 11780 70733319
Neutropenia 84.82 9.63 359 182986 256797 70488302
Sepsis 84.66 9.63 335 183010 244210 70500889
Drug withdrawal syndrome 83.75 9.63 229 183116 32486 70712613
Arthralgia 81.50 9.63 870 182475 502520 70242579
Peripheral swelling 81.30 9.63 325 183020 236238 70508861
Stomatitis 81.28 9.63 129 183216 128382 70616717
Lower respiratory tract infection 81.05 9.63 102 183243 111811 70633288
Depressed mood 80.50 9.63 273 183072 43547 70701552
Electrocardiogram QRS complex prolonged 79.78 9.63 112 183233 9694 70735405
Hyperreflexia 79.19 9.63 97 183248 7345 70737754
Sexual dysfunction 79.19 9.63 92 183253 6589 70738510
Anger 78.68 9.63 146 183199 15986 70729113
Folliculitis 78.54 9.63 9 183336 42561 70702538
Pyrexia 77.87 9.63 1103 182242 605849 70139250
Rash 77.66 9.63 895 182450 509667 70235432
Multiple organ dysfunction syndrome 77.45 9.63 100 183245 108415 70636684
Infection 77.32 9.63 282 183063 210503 70534596
Neuroleptic malignant syndrome 76.76 9.63 192 183153 25815 70719284
Muscle injury 76.68 9.63 6 183339 38488 70706611
Hallucination 75.39 9.63 393 182952 75867 70669232
Major depression 74.37 9.63 101 183244 8473 70736626
Reversible cerebral vasoconstriction syndrome 74.22 9.63 59 183286 2626 70742473
Hypersensitivity 72.62 9.63 326 183019 229486 70515613
Alopecia 71.19 9.63 268 183077 198222 70546877
Long QT syndrome 71.05 9.63 78 183267 5249 70739850
Intrusive thoughts 70.87 9.63 30 183315 387 70744712
Hallucination, visual 69.83 9.63 200 183145 29137 70715962
Sympathomimetic effect 69.34 9.63 19 183326 52 70745047
Drug ineffective 69.25 9.63 1876 181469 937876 69807223
Off label use 69.21 9.63 1431 181914 741629 70003470
Renal impairment 67.47 9.63 172 183173 143765 70601334
Clonus 67.18 9.63 82 183263 6186 70738913
Psychotic disorder 65.86 9.63 231 183114 37470 70707629
Hallucination, auditory 65.72 9.63 146 183199 18182 70726917
Impaired healing 64.80 9.63 58 183287 74316 70670783
C-reactive protein abnormal 64.50 9.63 11 183334 38568 70706531
Inflammation 64.26 9.63 65 183280 78600 70666499
Drug hypersensitivity 62.65 9.63 409 182936 262050 70483049
Multiple sclerosis relapse 62.18 9.63 248 183097 42769 70702330
Abnormal behaviour 61.79 9.63 214 183131 34495 70710604
Interstitial lung disease 61.66 9.63 110 183235 104575 70640524
Extrapyramidal disorder 61.04 9.63 153 183192 20597 70724502
Activation syndrome 60.92 9.63 24 183321 254 70744845
Septic shock 60.83 9.63 124 183221 112134 70632965
Depressed level of consciousness 60.30 9.63 410 182935 87021 70658078
Psychomotor hyperactivity 59.98 9.63 127 183218 15306 70729793
Homicidal ideation 59.47 9.63 57 183288 3266 70741833
Bruxism 59.36 9.63 60 183285 3669 70741430
Hepatic enzyme increased 58.90 9.63 208 183137 156782 70588317
Loss of libido 58.82 9.63 50 183295 2447 70742652
Drug abuse 57.99 9.63 609 182736 146647 70598452
Libido decreased 57.10 9.63 67 183278 4849 70740250
Gun shot wound 56.96 9.63 36 183309 1107 70743992
Myelosuppression 56.55 9.63 6 183339 30139 70714960
Derealisation 56.37 9.63 40 183305 1496 70743603
Therapeutic product effect decreased 56.02 9.63 186 183159 142832 70602267
C-reactive protein increased 55.79 9.63 127 183218 110390 70634709
Cardiac failure 55.32 9.63 188 183157 143353 70601746
Cytomegalovirus infection 55.20 9.63 17 183328 39741 70705358
Vital capacity decreased 54.76 9.63 38 183307 1371 70743728
Reversible airways obstruction 54.75 9.63 40 183305 1567 70743532
Blister 54.50 9.63 111 183234 100415 70644684
Amnesia 54.49 9.63 273 183072 51882 70693217
Tachyphrenia 54.20 9.63 43 183302 1908 70743191
Hypertonia 54.03 9.63 75 183270 6423 70738676
Feeling abnormal 53.44 9.63 583 182762 141736 70603363
Anhedonia 52.98 9.63 115 183230 14098 70731001
Toxicity to various agents 52.81 9.63 1327 182018 380845 70364254
Platelet count decreased 52.64 9.63 259 183086 177963 70567136
Discomfort 52.55 9.63 122 183223 105314 70639785
Thrombocytopenia 51.94 9.63 383 182962 238727 70506372
Pneumonia 51.15 9.63 1163 182182 595069 70150030
Memory impairment 51.10 9.63 412 182933 92229 70652870
Cholecystitis chronic 51.02 9.63 89 183256 9287 70735812
Delusion 50.90 9.63 136 183209 19029 70726070
Abdominal discomfort 50.46 9.63 336 183009 214322 70530777
Pancytopenia 50.37 9.63 210 183135 150897 70594202
Suicidal behaviour 50.17 9.63 50 183295 3006 70742093
Libido increased 49.39 9.63 40 183305 1829 70743270
Bipolar disorder 49.15 9.63 78 183267 7530 70737569
Emotional distress 48.71 9.63 208 183137 36980 70708119
Cerebral haematoma 48.15 9.63 76 183269 7302 70737797
Bone marrow failure 47.99 9.63 34 183311 48976 70696123
Galactorrhoea 47.74 9.63 51 183294 3327 70741772
Dizziness 45.82 9.63 1545 181800 462596 70282503
Alcoholism 45.79 9.63 57 183288 4388 70740711
Spirometry abnormal 45.21 9.63 26 183319 671 70744428
Muscle twitching 45.10 9.63 133 183212 19694 70725405
Hypomania 44.50 9.63 66 183279 6006 70739093
Abnormal dreams 44.43 9.63 90 183255 10513 70734586
Mobility decreased 43.82 9.63 129 183216 102870 70642229
Parkinsonism 43.00 9.63 111 183234 15214 70729885
Psychomotor retardation 42.69 9.63 62 183283 5536 70739563
Tonsillar ulcer 41.87 9.63 21 183324 408 70744691
Hyperthermia 40.99 9.63 115 183230 16556 70728543
Affective disorder 40.70 9.63 71 183274 7408 70737691
Drug screen positive 40.69 9.63 62 183283 5778 70739321
Hypersomnia 40.48 9.63 132 183213 20632 70724467
Adjustment disorder with mixed anxiety and depressed mood 39.97 9.63 13 183332 74 70745025
Pneumocystis jirovecii pneumonia 39.77 9.63 14 183331 30068 70715031
Mucosal inflammation 39.31 9.63 72 183273 67778 70677321
Disseminated intravascular coagulation 38.99 9.63 19 183326 33579 70711520
Bronchial secretion retention 38.30 9.63 43 183302 2967 70742132
Blood creatinine increased 38.20 9.63 215 183130 142786 70602313
Abulia 38.18 9.63 26 183319 909 70744190
Myoclonus 38.13 9.63 152 183193 26203 70718896
Alcohol use 37.87 9.63 53 183292 4574 70740525
Dyspnoea 37.86 9.63 1617 181728 768443 69976656
Anaemia 37.68 9.63 776 182569 402647 70342452
Screaming 37.68 9.63 47 183298 3625 70741474
Depressive symptom 37.51 9.63 56 183289 5125 70739974
Death 37.43 9.63 1018 182327 509043 70236056
Arthritis 37.28 9.63 129 183216 97851 70647248
Disorientation 37.21 9.63 267 183078 57656 70687443
Irritable bowel syndrome 37.17 9.63 46 183299 50804 70694295
Osteoporosis 37.07 9.63 43 183302 48864 70696235
Malignant neoplasm progression 37.05 9.63 175 183170 121564 70623535
Sedation 37.03 9.63 227 183118 46504 70698595
Bradypnoea 36.69 9.63 57 183288 5402 70739697
Catatonia 36.44 9.63 71 183274 8062 70737037
Impulsive behaviour 36.17 9.63 40 183305 2714 70742385
Social avoidant behaviour 36.14 9.63 52 183293 4604 70740495
Sleep disorder 35.99 9.63 306 183039 69566 70675533
Generalised tonic-clonic seizure 35.98 9.63 207 183138 41454 70703645
Neutropenic sepsis 35.60 9.63 10 183335 24820 70720279
Bradyphrenia 35.40 9.63 79 183266 9867 70735232
Hepatic function abnormal 35.24 9.63 77 183268 67919 70677180
Product use issue 34.98 9.63 297 183048 179640 70565459
Nightmare 34.68 9.63 131 183214 22025 70723074
Nasopharyngitis 34.27 9.63 388 182957 221818 70523281
Self esteem decreased 33.56 9.63 24 183321 909 70744190
Device dislocation 33.52 9.63 131 183214 22376 70722723
Red blood cell sedimentation rate abnormal 33.40 9.63 5 183340 19298 70725801
Obsessive-compulsive disorder 33.24 9.63 54 183291 5316 70739783
Sinus bradycardia 33.18 9.63 135 183210 23488 70721611
Persecutory delusion 32.96 9.63 49 183296 4468 70740631
Optic nerve injury 32.91 9.63 20 183325 573 70744526
Pregnancy 32.69 9.63 135 183210 23646 70721453
Anorgasmia 32.50 9.63 25 183320 1060 70744039
Aspergillus infection 32.41 9.63 4 183341 17864 70727235
Emotional disorder 32.28 9.63 91 183254 13135 70731964
Mood swings 31.90 9.63 112 183233 18174 70726925
Hostility 31.79 9.63 34 183311 2221 70742878
Negative thoughts 31.73 9.63 27 183318 1323 70743776
Myocardial infarction 31.73 9.63 287 183058 171358 70573741
Sinusitis 31.67 9.63 282 183063 168913 70576186
Maternal exposure during pregnancy 31.03 9.63 173 183172 115172 70629927
Orgasm abnormal 30.90 9.63 13 183332 165 70744934
Knee arthroplasty 30.78 9.63 26 183319 34275 70710824
Poor quality sleep 30.76 9.63 119 183226 20230 70724869
Drug resistance 30.68 9.63 32 183313 38158 70706941
Mite allergy 30.58 9.63 22 183323 841 70744258
Cogwheel rigidity 30.48 9.63 38 183307 2930 70742169
Neutrophil count decreased 30.46 9.63 112 183233 83444 70661655
Resting tremor 30.45 9.63 27 183318 1399 70743700
Head injury 30.38 9.63 171 183174 33970 70711129
Pain in extremity 30.34 9.63 632 182713 327450 70417649
Pain 30.32 9.63 1323 182022 627493 70117606
Oculogyric crisis 30.06 9.63 36 183309 2662 70742437
Behaviour disorder 29.90 9.63 52 183293 5412 70739687
Sputum culture positive 29.83 9.63 40 183305 3314 70741785
Bronchopulmonary aspergillosis 29.12 9.63 9 183336 20993 70724106
Acute myocardial infarction 29.07 9.63 94 183251 72793 70672306
Erectile dysfunction 28.98 9.63 89 183256 13473 70731626
Dystonia 28.79 9.63 114 183231 19592 70725507
Somnambulism 28.71 9.63 50 183295 5210 70739889
Pulmonary embolism 28.68 9.63 564 182781 155303 70589796
Alcohol abuse 28.47 9.63 49 183296 5058 70740041
Pruritus 28.44 9.63 678 182667 344882 70400217
Syncope 28.30 9.63 593 182752 165116 70579983
Hip arthroplasty 28.05 9.63 19 183326 28021 70717078
Restless legs syndrome 28.05 9.63 108 183237 18320 70726779
Skin ulcer 27.97 9.63 51 183294 48094 70697005
Lower respiratory tract infection viral 27.89 9.63 23 183322 1079 70744020
Legal problem 27.86 9.63 12 183333 162 70744937
Gestational diabetes 27.64 9.63 53 183292 5948 70739151
Multiple sclerosis 27.58 9.63 134 183211 25151 70719948
Plasma cell myeloma 27.43 9.63 97 183248 73104 70671995
Miosis 26.91 9.63 89 183256 14012 70731087
Musculoskeletal stiffness 26.90 9.63 248 183097 147512 70597587
Disease progression 26.81 9.63 267 183078 156405 70588694
Feeling jittery 26.80 9.63 78 183267 11465 70733634
Renal failure 26.52 9.63 337 183008 188733 70556366
Morose 26.51 9.63 8 183337 34 70745065
Feeling guilty 26.14 9.63 20 183325 841 70744258
Disinhibition 26.13 9.63 31 183314 2270 70742829
Platelet aggregation inhibition 26.12 9.63 11 183334 140 70744959
Bone erosion 26.09 9.63 4 183341 15169 70729930
Rheumatoid nodule 25.85 9.63 4 183341 15063 70730036
Bundle branch block left 25.83 9.63 72 183273 10327 70734772
Fibromyalgia 25.82 9.63 53 183292 47821 70697278
Sinus tachycardia 25.78 9.63 163 183182 33750 70711349
Mental status changes 25.78 9.63 263 183082 62838 70682261
Feeling of despair 25.73 9.63 33 183312 2618 70742481
Thermohypoaesthesia 25.71 9.63 10 183335 102 70744997
Respiratory arrest 25.59 9.63 232 183113 53701 70691398
Poisoning 25.47 9.63 121 183224 22501 70722598
Tachycardia 25.35 9.63 562 182783 157984 70587115
Orthostatic hypotension 25.28 9.63 224 183121 51519 70693580
Nervousness 25.18 9.63 152 183193 30968 70714131
Sepsis neonatal 25.13 9.63 8 183337 42 70745057
Bradycardia 25.01 9.63 457 182888 124158 70620941
Stiff person syndrome 25.00 9.63 14 183331 343 70744756
Delirium 24.99 9.63 299 183046 74315 70670784
Sight disability 24.88 9.63 10 183335 112 70744987
Conjunctivitis allergic 24.71 9.63 22 183323 1146 70743953
Initial insomnia 24.61 9.63 52 183293 6257 70738842
Moaning 24.53 9.63 21 183324 1038 70744061
Angle closure glaucoma 24.50 9.63 33 183312 2746 70742353
Pyramidal tract syndrome 24.15 9.63 16 183329 534 70744565
Learning disorder 24.02 9.63 16 183329 539 70744560
Conversion disorder 24.02 9.63 26 183319 1722 70743377
Mycotic allergy 23.77 9.63 21 183324 1083 70744016
Judgement impaired 23.77 9.63 21 183324 1083 70744016
Ill-defined disorder 23.69 9.63 68 183277 54673 70690426
Muscle necrosis 23.60 9.63 23 183322 1345 70743754
Dysphoria 23.57 9.63 42 183303 4456 70740643
Lip ulceration 23.50 9.63 28 183317 2060 70743039
Tumour lysis syndrome 23.42 9.63 13 183332 21347 70723752
Postictal state 23.38 9.63 25 183320 1633 70743466
Red blood cell sedimentation rate increased 23.29 9.63 40 183305 38602 70706497
White blood cell count decreased 23.22 9.63 305 183040 169836 70575263
Dysgraphia 23.13 9.63 37 183308 3595 70741504
Transplant rejection 23.10 9.63 9 183336 18162 70726937
Electrocardiogram QT interval 23.00 9.63 11 183334 192 70744907
Haemophagocytic lymphohistiocytosis 22.89 9.63 11 183334 19601 70725498
Hypertension 22.67 9.63 587 182758 295446 70449653
Yawning 22.60 9.63 22 183323 1285 70743814
Dust allergy 22.51 9.63 21 183324 1163 70743936
Uterine perforation 22.34 9.63 48 183297 5843 70739256
Mental impairment 22.20 9.63 96 183249 17159 70727940
Ejaculation failure 22.14 9.63 13 183332 349 70744750
Headache 22.12 9.63 1764 181581 578641 70166458
Thinking abnormal 22.05 9.63 75 183270 11976 70733123
Treatment noncompliance 21.92 9.63 200 183145 46374 70698725
Fear 21.78 9.63 109 183236 20702 70724397
Bradykinesia 21.73 9.63 55 183290 7447 70737652
Nausea 21.72 9.63 2517 180828 849571 69895528
Acute myeloid leukaemia 21.57 9.63 29 183316 30911 70714188
Post-traumatic neck syndrome 21.45 9.63 26 183319 1947 70743152
Victim of sexual abuse 21.36 9.63 14 183331 459 70744640
Self-injurious ideation 21.25 9.63 34 183311 3304 70741795
Ascites 21.20 9.63 96 183249 67451 70677648
Haemoglobin decreased 21.14 9.63 388 182957 204771 70540328
Atrial fibrillation 21.13 9.63 342 183003 184006 70561093
Middle insomnia 21.10 9.63 82 183263 13971 70731128
Cardiac failure congestive 21.08 9.63 236 183109 135221 70609878
Antiphospholipid antibodies 21.06 9.63 9 183336 119 70744980
Logorrhoea 21.03 9.63 38 183307 4076 70741023
Neuropathy peripheral 20.98 9.63 218 183127 126678 70618421
Blood prolactin increased 20.90 9.63 36 183309 3718 70741381
Heavy menstrual bleeding 20.75 9.63 76 183269 12589 70732510
Foot deformity 20.66 9.63 14 183331 20641 70724458
Psychiatric symptom 20.61 9.63 50 183295 6594 70738505
Epilepsy 20.57 9.63 171 183174 38613 70706486
Sleep-related eating disorder 20.50 9.63 16 183329 693 70744406
Band sensation 20.44 9.63 16 183329 696 70744403
Bipolar I disorder 20.42 9.63 25 183320 1892 70743207
Tension 20.36 9.63 37 183308 3987 70741112
Tearfulness 20.31 9.63 42 183303 4978 70740121
Weight increased 20.25 9.63 792 182553 241539 70503560
Hyperglycaemia 20.24 9.63 92 183253 64580 70680519
Gambling disorder 20.20 9.63 25 183320 1913 70743186
Device expulsion 20.18 9.63 112 183233 22134 70722965
Anaphylactic shock 20.17 9.63 33 183312 32457 70712642
Male orgasmic disorder 20.06 9.63 7 183338 51 70745048
Upper-airway cough syndrome 20.00 9.63 63 183282 9668 70735431
Graft versus host disease 19.84 9.63 7 183338 15016 70730083
Suspected suicide 19.84 9.63 59 183286 8775 70736324
Migraine 19.79 9.63 279 183066 71959 70673140
Euphoric mood 19.43 9.63 50 183295 6839 70738260
Reduced facial expression 19.34 9.63 27 183318 2325 70742774
Slow speech 19.28 9.63 26 183319 2166 70742933
Psoriatic arthropathy 19.18 9.63 94 183251 64677 70680422
Torticollis 19.12 9.63 26 183319 2183 70742916
Family stress 19.08 9.63 15 183330 657 70744442
Hypervigilance 19.05 9.63 13 183332 456 70744643
Immobilisation prolonged 18.98 9.63 8 183337 102 70744997
Biliary dyskinesia 18.92 9.63 27 183318 2372 70742727
Erythema 18.85 9.63 383 182962 199180 70545919
Deep vein thrombosis 18.83 9.63 397 182948 110645 70634454
Intentional product use issue 18.82 9.63 209 183136 119933 70625166
Chest injury 18.75 9.63 28 183317 2563 70742536
Tubulointerstitial nephritis 18.37 9.63 36 183309 33040 70712059
Dissociative disorder 18.35 9.63 13 183332 485 70744614
Retroplacental haematoma 18.18 9.63 8 183337 114 70744985
Painful respiration 18.17 9.63 31 183314 3177 70741922
Illness anxiety disorder 18.11 9.63 10 183335 238 70744861
Prostate cancer 18.11 9.63 33 183312 31130 70713969
Foetal exposure during pregnancy 18.07 9.63 43 183302 5602 70739497
Nephropathy toxic 17.92 9.63 13 183332 18501 70726598
Tongue biting 17.92 9.63 23 183322 1826 70743273
Intermenstrual bleeding 17.90 9.63 41 183304 5209 70739890
Carcinoid syndrome 17.80 9.63 9 183336 178 70744921
Self-medication 17.77 9.63 37 183308 4406 70740693
Parkinsonian gait 17.74 9.63 16 183329 848 70744251
Gynaecomastia 17.70 9.63 48 183297 6775 70738324
Obsessive-compulsive personality disorder 17.70 9.63 8 183337 122 70744977
Bundle branch block right 17.66 9.63 64 183281 10546 70734553
Panic reaction 17.59 9.63 36 183309 4235 70740864
Head banging 17.56 9.63 13 183332 520 70744579
Enterocolitis 17.41 9.63 6 183339 13060 70732039
Concussion 17.41 9.63 55 183290 8454 70736645
Breast swelling 17.38 9.63 18 183327 1133 70743966
Hepatotoxicity 17.35 9.63 57 183288 43929 70701170
Barotrauma 17.32 9.63 9 183336 189 70744910
Gallbladder disorder 17.30 9.63 91 183254 17621 70727478
Cellulitis 17.16 9.63 168 183177 98760 70646339
Compulsions 17.10 9.63 11 183334 349 70744750
Obsessive thoughts 17.00 9.63 17 183328 1026 70744073
Haemoglobin urine 16.97 9.63 8 183337 135 70744964
Drug withdrawal syndrome neonatal 16.92 9.63 10 183335 272 70744827
Lethargy 16.90 9.63 281 183064 74969 70670130
Angina pectoris 16.89 9.63 66 183279 48317 70696782
Pulmonary fibrosis 16.85 9.63 40 183305 34270 70710829
Creatinine renal clearance decreased 16.75 9.63 12 183333 17188 70727911
Palmar-plantar erythrodysaesthesia syndrome 16.73 9.63 33 183312 30214 70714885
Speech disorder 16.63 9.63 202 183143 50378 70694721
Decreased interest 16.60 9.63 31 183314 3410 70741689
Grandiosity 16.58 9.63 13 183332 567 70744532
Respiratory failure 16.48 9.63 322 183023 168413 70576686
Trunk injury 16.43 9.63 5 183340 22 70745077
Skin dystrophy 16.39 9.63 6 183339 51 70745048
Kidney transplant rejection 16.30 9.63 3 183342 9958 70735141
Pulmonary toxicity 16.14 9.63 4 183341 10794 70734305
Urinary retention 16.09 9.63 207 183138 52313 70692786
Large intestine anastomosis 16.09 9.63 7 183338 97 70745002
Epstein-Barr virus infection 16.03 9.63 7 183338 13191 70731908
Soft tissue injury 16.03 9.63 21 183324 1701 70743398
Vertigo 15.99 9.63 239 183106 62404 70682695
Osteoarthritis 15.96 9.63 119 183226 74028 70671071
Partner stress 15.81 9.63 10 183335 308 70744791
Multiple allergies 15.73 9.63 50 183295 7710 70737389
Cerebral thrombosis 15.63 9.63 24 183321 2252 70742847
General physical health deterioration 15.52 9.63 478 182867 235553 70509546
Cardio-respiratory arrest 15.50 9.63 355 182990 100322 70644777
Neoplasm malignant 15.39 9.63 32 183313 28742 70716357
Personality disorder 15.37 9.63 40 183305 5508 70739591
Freezing phenomenon 15.33 9.63 20 183325 1614 70743485
Drug screen false positive 15.32 9.63 16 183329 1017 70744082
Hypokinesia 15.30 9.63 87 183258 17345 70727754
Coma scale abnormal 15.29 9.63 51 183294 8065 70737034
Leukopenia 15.28 9.63 189 183156 106371 70638728
Psychomotor skills impaired 15.22 9.63 34 183311 4250 70740849
Sleep talking 15.22 9.63 16 183329 1025 70744074
Pneumonitis 15.17 9.63 81 183264 54516 70690583
Rectal ulcer 15.15 9.63 22 183323 1964 70743135
Left ventricle outflow tract obstruction 15.14 9.63 10 183335 332 70744767
Hypophosphataemia 15.11 9.63 12 183333 16314 70728785
Retrograde amnesia 15.06 9.63 12 183333 536 70744563
Hemianopia 15.03 9.63 20 183325 1645 70743454
Imprisonment 15.00 9.63 12 183333 539 70744560
Neoplasm progression 14.97 9.63 63 183282 45165 70699934
Brain stem haematoma 14.96 9.63 7 183338 116 70744983
Cough 14.93 9.63 688 182657 324689 70420410
Tinnitus 14.88 9.63 151 183194 36025 70709074
Reactive psychosis 14.86 9.63 4 183341 10 70745089
Myositis 14.80 9.63 14 183331 17475 70727624
Cerebellar syndrome 14.79 9.63 38 183307 5193 70739906
Aphasia 14.78 9.63 174 183171 43075 70702024
Anterograde amnesia 14.74 9.63 13 183332 669 70744430
Pleural effusion 14.72 9.63 248 183097 132616 70612483
Diffuse large B-cell lymphoma 14.72 9.63 8 183337 13294 70731805
Ocular hypertension 14.62 9.63 18 183327 1370 70743729
Inappropriate affect 14.56 9.63 18 183327 1376 70743723
Spinal cord oedema 14.50 9.63 10 183335 357 70744742
Caesarean section 14.49 9.63 64 183281 11543 70733556
Basal cell carcinoma 14.48 9.63 42 183303 33656 70711443
Road traffic accident 14.38 9.63 145 183200 34537 70710562
Hepatitis infectious mononucleosis 14.34 9.63 7 183338 128 70744971
Focal dyscognitive seizures 14.31 9.63 29 183316 3388 70741711
Postural orthostatic tachycardia syndrome 14.30 9.63 12 183333 577 70744522
Pneumonia fungal 14.28 9.63 4 183341 9949 70735150
Musculoskeletal pain 14.19 9.63 157 183188 90170 70654929
Lupus-like syndrome 14.16 9.63 6 183339 11509 70733590
Device placement issue 14.11 9.63 14 183331 837 70744262
Dysarthria 14.11 9.63 233 183112 62080 70683019
Electrocardiogram abnormal 14.09 9.63 75 183270 14589 70730510
Wheezing 13.89 9.63 166 183179 94004 70651095
Extradural haematoma 13.85 9.63 25 183320 2680 70742419
Autonomic nervous system imbalance 13.83 9.63 33 183312 4306 70740793
Apnoea 13.80 9.63 60 183285 10749 70734350
Neurotoxicity 13.69 9.63 36 183309 29790 70715309
Electrocardiogram QT interval abnormal 13.68 9.63 9 183336 297 70744802
Cyclic vomiting syndrome 13.67 9.63 6 183339 85 70745014
Osteonecrosis of jaw 13.64 9.63 57 183288 40945 70704154
Hyperphagia 13.63 9.63 23 183322 2336 70742763
Flight of ideas 13.59 9.63 13 183332 743 70744356
Drug-induced liver injury 13.59 9.63 87 183258 56026 70689073
Belligerence 13.57 9.63 9 183336 301 70744798
Ventricular dyskinesia 13.55 9.63 10 183335 398 70744701
Intraventricular haemorrhage 13.52 9.63 33 183312 4368 70740731
Product substitution error 13.51 9.63 5 183340 44 70745055
Impaired driving ability 13.44 9.63 35 183310 4822 70740277
Sebaceous gland infection 13.43 9.63 7 183338 148 70744951
Inhibitory drug interaction 13.28 9.63 30 183315 3777 70741322
Bladder cancer 13.24 9.63 15 183330 17227 70727872
Atrial flutter 13.23 9.63 20 183325 20307 70724792
Unresponsive to stimuli 13.20 9.63 198 183147 51733 70693366
Device related infection 13.19 9.63 41 183304 32144 70712955
Bursitis 13.17 9.63 31 183314 26642 70718457
Liver disorder 13.16 9.63 99 183246 61469 70683630
Compulsive shopping 13.13 9.63 13 183332 775 70744324
Abortion spontaneous 13.12 9.63 115 183230 26364 70718735
Ovarian vein thrombosis 13.12 9.63 5 183340 48 70745051
Colitis microscopic 13.08 9.63 52 183293 8953 70736146
Mood altered 13.03 9.63 80 183265 16395 70728704
Balance disorder 13.01 9.63 315 183030 89813 70655286
Oesophageal carcinoma 13.01 9.63 4 183341 9362 70735737
Neuromyelitis optica spectrum disorder 12.90 9.63 15 183330 1075 70744024
Victim of crime 12.88 9.63 10 183335 430 70744669
Haematoma 12.86 9.63 186 183159 48232 70696867
Hypermetropia 12.86 9.63 10 183335 431 70744668
Menometrorrhagia 12.84 9.63 12 183333 666 70744433
Priapism 12.82 9.63 31 183314 4079 70741020
Hypogammaglobulinaemia 12.68 9.63 7 183338 11531 70733568
Anxiety disorder 12.67 9.63 30 183315 3895 70741204
Electroencephalogram abnormal 12.66 9.63 36 183309 5222 70739877
Alcohol poisoning 12.64 9.63 32 183313 4333 70740766
Respiratory disorder 12.64 9.63 55 183290 39068 70706031
Hot flush 12.59 9.63 189 183156 49395 70695704
Hyperventilation 12.52 9.63 44 183301 7142 70737957
Drug eruption 12.47 9.63 56 183289 39440 70705659
Pelvic pain 12.42 9.63 61 183284 11499 70733600
Peripheral sensory neuropathy 12.39 9.63 8 183337 12102 70732997
Nephrotic syndrome 12.37 9.63 6 183339 10634 70734465
Complication of device insertion 12.35 9.63 36 183309 5296 70739803
Cytopenia 12.32 9.63 16 183329 17307 70727792
Anaphylactic reaction 12.31 9.63 129 183216 74845 70670254
Attention-seeking behaviour 12.28 9.63 6 183339 110 70744989
Dissociation 12.22 9.63 27 183318 3349 70741750
Superior sagittal sinus thrombosis 12.19 9.63 14 183331 990 70744109
Thrombotic microangiopathy 12.17 9.63 17 183328 17831 70727268
Hepatitis chronic active 12.16 9.63 7 183338 181 70744918
Joint hyperextension 12.13 9.63 8 183337 265 70744834
Gastric cancer 12.13 9.63 4 183341 8951 70736148
Illusion 12.11 9.63 18 183327 1641 70743458
Cytotoxic oedema 12.07 9.63 9 183336 364 70744735
Schizoaffective disorder 12.06 9.63 20 183325 2003 70743096
Total lung capacity abnormal 12.06 9.63 7 183338 184 70744915
Ejection fraction decreased 12.04 9.63 40 183305 30722 70714377
Cognitive disorder 12.03 9.63 223 183122 60733 70684366
Retinal ischaemia 12.03 9.63 12 183333 722 70744377
Gastrointestinal haemorrhage 12.01 9.63 267 183078 137141 70607958
Pulmonary arterial hypertension 12.00 9.63 44 183301 32811 70712288
Coronary artery disease 11.98 9.63 104 183241 62632 70682467
Hypercalcaemia 11.94 9.63 47 183298 34338 70710761
Extensor plantar response 11.94 9.63 18 183327 1662 70743437
Gastrointestinal disorder 11.94 9.63 196 183149 105231 70639868
Gastrointestinal procedural complication 11.92 9.63 7 183338 188 70744911
Mucormycosis 11.92 9.63 3 183342 8011 70737088
Sperm concentration decreased 11.78 9.63 5 183340 65 70745034
Laryngectomy 11.72 9.63 4 183341 27 70745072
Retching 11.65 9.63 76 183269 15903 70729196
Skin necrosis 11.63 9.63 15 183330 16276 70728823
Polydipsia 11.61 9.63 38 183307 5950 70739149
Anti-actin antibody positive 11.60 9.63 3 183342 6 70745093
Wound healing normal 11.60 9.63 3 183342 6 70745093
Bacteraemia 11.55 9.63 38 183307 29271 70715828
Dermatitis atopic 11.50 9.63 50 183295 8957 70736142
Gambling 11.49 9.63 8 183337 290 70744809
Female orgasmic disorder 11.48 9.63 4 183341 29 70745070
Flat affect 11.45 9.63 19 183326 1904 70743195
Cardiac arrest 11.44 9.63 514 182831 159320 70585779
Rash maculo-papular 11.42 9.63 80 183265 50465 70694634
Endometrial disorder 11.41 9.63 10 183335 510 70744589
Increased appetite 11.40 9.63 56 183289 10557 70734542
Metabolic acidosis 11.37 9.63 130 183215 74216 70670883
Enthesopathy 11.37 9.63 7 183338 10862 70734237
Ejaculation disorder 11.35 9.63 10 183335 514 70744585
Oedema peripheral 11.33 9.63 478 182867 227613 70517486
Cholangitis 11.32 9.63 8 183337 11541 70733558
Oedema 11.26 9.63 194 183151 103387 70641712
Lactation disorder 11.20 9.63 7 183338 211 70744888
Cataract 11.18 9.63 91 183254 55554 70689545
Stoma site discharge 11.16 9.63 18 183327 1761 70743338
Polyarthritis 11.15 9.63 7 183338 10749 70734350
Inflammatory marker increased 11.14 9.63 5 183340 9269 70735830
Sternal fracture 11.12 9.63 21 183324 2330 70742769
Sialoadenitis 11.07 9.63 18 183327 1774 70743325
Lactic acidosis 11.04 9.63 111 183234 64913 70680186
Dry mouth 11.01 9.63 249 183096 70208 70674891
Burnout syndrome 11.00 9.63 8 183337 311 70744788
Disorganised speech 11.00 9.63 18 183327 1783 70743316
Angina unstable 10.97 9.63 15 183330 15878 70729221
Metastases to lung 10.94 9.63 16 183329 16468 70728631
Optic atrophy 10.90 9.63 18 183327 1797 70743302
Coordination abnormal 10.86 9.63 75 183270 15991 70729108
Myelodysplastic syndrome 10.80 9.63 40 183305 29745 70715354
Posterior reversible encephalopathy syndrome 10.79 9.63 30 183315 24372 70720727
Lung consolidation 10.75 9.63 4 183341 8302 70736797
Diarrhoea 10.74 9.63 1821 181524 781520 69963579
Carboxyhaemoglobin increased 10.73 9.63 4 183341 36 70745063
Cytokine release syndrome 10.65 9.63 34 183311 26433 70718666
Arthritis bacterial 10.60 9.63 4 183341 8229 70736870
Blood urea nitrogen/creatinine ratio decreased 10.57 9.63 5 183340 85 70745014
Suture rupture 10.56 9.63 10 183335 564 70744535
Drug dependence 10.56 9.63 145 183200 37176 70707923
Ileus 10.56 9.63 30 183315 24207 70720892
Delusional disorder, erotomanic type 10.54 9.63 4 183341 38 70745061
Merycism 10.53 9.63 7 183338 235 70744864
Bile acid malabsorption 10.53 9.63 7 183338 235 70744864
Hyperkalaemia 10.53 9.63 203 183142 106388 70638711
Homicide 10.48 9.63 14 183331 1156 70743943
Staring 10.47 9.63 21 183324 2435 70742664
Blood pressure diastolic decreased 10.45 9.63 33 183312 25747 70719352
Creatinine urine decreased 10.40 9.63 7 183338 240 70744859
Bronchiectasis 10.32 9.63 16 183329 16081 70729018
Female sexual dysfunction 10.27 9.63 4 183341 41 70745058
Shoulder deformity 10.27 9.63 4 183341 41 70745058
Pseudomonas infection 10.27 9.63 21 183324 18973 70726126
Eosinophil count increased 10.26 9.63 71 183274 15151 70729948
Nephropathy 10.22 9.63 5 183340 8820 70736279
Foreign body in reproductive tract 10.22 9.63 9 183336 462 70744637
Nuchal rigidity 10.22 9.63 13 183332 1023 70744076
Tension headache 10.20 9.63 26 183319 3535 70741564
Paraesthesia 10.19 9.63 467 182878 145070 70600029
Cerebellar haematoma 10.10 9.63 10 183335 596 70744503
Antipsychotic drug level increased 10.08 9.63 34 183311 5406 70739693
Xerophthalmia 10.05 9.63 10 183335 600 70744499
Blood alcohol increased 10.05 9.63 14 183331 1203 70743896
Amenorrhoea 10.05 9.63 40 183305 6890 70738209
Injury 10.02 9.63 230 183115 65015 70680084
Asphyxia 10.01 9.63 53 183292 10289 70734810
Erection increased 10.01 9.63 8 183337 359 70744740
Colitis 9.99 9.63 111 183234 63703 70681396
Delusion of grandeur 9.94 9.63 12 183333 895 70744204
Exposure via breast milk 9.94 9.63 12 183333 895 70744204
Substance abuse 9.93 9.63 51 183294 9786 70735313
Emotional poverty 9.91 9.63 11 183334 749 70744350
Hypochloraemia 9.91 9.63 19 183326 2132 70742967
Antidepressant discontinuation syndrome 9.89 9.63 3 183342 13 70745086
Hyperdynamic left ventricle 9.89 9.63 8 183337 365 70744734
Pulmonary hypertension 9.87 9.63 75 183270 46461 70698638
Cardiogenic shock 9.85 9.63 140 183205 36167 70708932
Anal stenosis 9.82 9.63 8 183337 369 70744730
Hypocoagulable state 9.80 9.63 18 183327 1955 70743144
Pulmonary tuberculosis 9.79 9.63 4 183341 7841 70737258
Peripheral venous disease 9.71 9.63 8 183337 10679 70734420
Aversion 9.71 9.63 4 183341 48 70745051
Blood gases abnormal 9.66 9.63 13 183332 1081 70744018

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Human herpesvirus 6 infection 34.80 32.07 15 835 45 88897

Pharmacologic Action:

SourceCodeDescription
ATC N06AB10 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:76779 post-proline endopeptidase inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Major depressive disorder indication 370143000
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Obsessive-compulsive disorder off-label use 191736004 DOID:10933
Menopausal flushing off-label use 198436008
Panic disorder off-label use 371631005 DOID:594
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Upper gastrointestinal hemorrhage contraindication 37372002
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Heart disease contraindication 56265001 DOID:114
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Epilepsy contraindication 84757009 DOID:1826
Hyponatremia contraindication 89627008
Disease of liver contraindication 235856003 DOID:409
Serotonin syndrome contraindication 371089000
Myocardial infarction in recovery phase contraindication 418044006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Ki 8.96 WOMBAT-PK CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.19 PDSP
5-hydroxytryptamine receptor 2C GPCR Ki 5.60 PDSP
Alpha-1A adrenergic receptor GPCR Ki 5.41 PDSP
Histamine H1 receptor GPCR Ki 5.71 PDSP
Muscarinic acetylcholine receptor M1 GPCR Ki 5.91 PDSP
Sodium-dependent serotonin transporter Transporter Ki 9.05 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.09 CHEMBL
Transporter Transporter Ki 4.98 CHEMBL

External reference:

IDSource
4024285 VUID
N0000022289 NUI
D02567 KEGG_DRUG
219861-08-2 SECONDARY_CAS_RN
4021356 VANDF
4024285 VANDF
C1099456 UMLSCUI
CHEBI:36791 CHEBI
CHEMBL1508 ChEMBL_ID
DB01175 DRUGBANK_ID
CHEMBL1200322 ChEMBL_ID
D000089983 MESH_DESCRIPTOR_UI
146570 PUBCHEM_CID
7177 IUPHAR_LIGAND_ID
7953 INN_ID
4O4S742ANY UNII
321988 RXNORM
158618 MMSL
16927 MMSL
187848 MMSL
d04812 MMSL
009709 NDDF
009710 NDDF
395246009 SNOMEDCT_US
400447003 SNOMEDCT_US
412384000 SNOMEDCT_US
68P PDB_CHEM_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0121-0852 SOLUTION 10 mg ORAL ANDA 36 sections
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0121-0852 SOLUTION 10 mg ORAL ANDA 36 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2005 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2005 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2010 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2010 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2020 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2020 TABLET, FILM COATED 20 mg ORAL NDA 32 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2101 SOLUTION 5 mg ORAL NDA 32 sections
Lexapro HUMAN PRESCRIPTION DRUG LABEL 1 0456-2101 SOLUTION 5 mg ORAL NDA 32 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7953 TABLET 5 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7954 TABLET 10 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-7955 TABLET 20 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8348 TABLET, FILM COATED 5 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8349 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8350 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8365 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Escitalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8366 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6426 TABLET 10 mg ORAL ANDA 30 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6426 TABLET 10 mg ORAL ANDA 30 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6427 TABLET 20 mg ORAL ANDA 30 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6427 TABLET 20 mg ORAL ANDA 30 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-224 TABLET 5 mg ORAL ANDA 29 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-225 TABLET 10 mg ORAL ANDA 29 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-230 TABLET 20 mg ORAL ANDA 29 sections
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-968 TABLET, FILM COATED 10 mg ORAL NDA authorized generic 32 sections
Escitalopram Oxalate HUMAN PRESCRIPTION DRUG LABEL 1 10544-969 TABLET, FILM COATED 20 mg ORAL NDA authorized generic 32 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 13668-135 TABLET 5 mg ORAL ANDA 28 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 13668-135 TABLET 5 mg ORAL ANDA 28 sections
escitalopram oxalate HUMAN PRESCRIPTION DRUG LABEL 1 13668-135 TABLET 5 mg ORAL ANDA 28 sections