Stem definition | Drug id | CAS RN |
---|---|---|
1053 | 128196-01-0 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 8 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.88 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 14, 2002 | FDA | FOREST LABS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Suicide attempt | 505.56 | 9.59 | 720 | 160217 | 57116 | 56074014 |
Suicidal ideation | 499.10 | 9.59 | 715 | 160222 | 57027 | 56074103 |
Depression | 498.64 | 9.59 | 1381 | 159556 | 178736 | 55952394 |
Intentional overdose | 488.44 | 9.59 | 773 | 160164 | 67344 | 56063786 |
Anxiety | 476.58 | 9.59 | 1421 | 159516 | 191751 | 55939379 |
Electrocardiogram QT prolonged | 464.54 | 9.59 | 671 | 160266 | 53917 | 56077213 |
Rheumatoid arthritis | 438.49 | 9.59 | 277 | 160660 | 382327 | 55748803 |
Pemphigus | 427.19 | 9.59 | 4 | 160933 | 157208 | 55973922 |
Serotonin syndrome | 385.91 | 9.59 | 426 | 160511 | 26064 | 56105066 |
Systemic lupus erythematosus | 353.63 | 9.59 | 48 | 160889 | 180030 | 55951100 |
Contraindicated product administered | 337.94 | 9.59 | 62 | 160875 | 186224 | 55944906 |
Synovitis | 331.38 | 9.59 | 37 | 160900 | 161268 | 55969862 |
Hand deformity | 331.34 | 9.59 | 12 | 160925 | 134480 | 55996650 |
Sopor | 326.65 | 9.59 | 349 | 160588 | 20573 | 56110557 |
Glossodynia | 296.09 | 9.59 | 42 | 160895 | 152416 | 55978714 |
Completed suicide | 287.59 | 9.59 | 939 | 159998 | 132894 | 55998236 |
Arthropathy | 286.78 | 9.59 | 107 | 160830 | 200168 | 55930962 |
Drug interaction | 280.30 | 9.59 | 1265 | 159672 | 208490 | 55922640 |
Overdose | 273.43 | 9.59 | 792 | 160145 | 105038 | 56026092 |
Somnolence | 265.30 | 9.59 | 1046 | 159891 | 162367 | 55968763 |
Treatment failure | 264.95 | 9.59 | 79 | 160858 | 170313 | 55960817 |
Joint swelling | 252.30 | 9.59 | 274 | 160663 | 289526 | 55841604 |
Drug intolerance | 222.13 | 9.59 | 258 | 160679 | 264560 | 55866570 |
Swelling | 218.43 | 9.59 | 218 | 160719 | 239553 | 55891577 |
Wound | 209.22 | 9.59 | 68 | 160869 | 138736 | 55992394 |
Infusion related reaction | 205.59 | 9.59 | 177 | 160760 | 208754 | 55922376 |
Pericarditis | 204.58 | 9.59 | 33 | 160904 | 108890 | 56022240 |
Alopecia | 200.00 | 9.59 | 332 | 160605 | 293126 | 55838004 |
Tremor | 194.70 | 9.59 | 773 | 160164 | 120316 | 56010814 |
Intentional self-injury | 183.66 | 9.59 | 287 | 160650 | 24705 | 56106425 |
Rheumatoid factor positive | 182.00 | 9.59 | 3 | 160934 | 69057 | 56062073 |
Duodenal ulcer perforation | 179.97 | 9.59 | 3 | 160934 | 68339 | 56062791 |
Hyponatraemia | 179.71 | 9.59 | 671 | 160266 | 101468 | 56029662 |
Helicobacter infection | 178.81 | 9.59 | 7 | 160930 | 73261 | 56057869 |
Drug ineffective | 177.00 | 9.59 | 1730 | 159207 | 917259 | 55213871 |
Product substitution issue | 161.51 | 9.59 | 204 | 160733 | 14395 | 56116735 |
Abdominal discomfort | 144.43 | 9.59 | 366 | 160571 | 276908 | 55854222 |
Agitation | 142.33 | 9.59 | 417 | 160520 | 55619 | 56075511 |
Therapeutic product effect decreased | 140.98 | 9.59 | 166 | 160771 | 169286 | 55961844 |
Inappropriate antidiuretic hormone secretion | 140.85 | 9.59 | 185 | 160752 | 13571 | 56117559 |
Coma | 139.33 | 9.59 | 431 | 160506 | 59224 | 56071906 |
Lower respiratory tract infection | 131.27 | 9.59 | 83 | 160854 | 114711 | 56016419 |
Akathisia | 127.45 | 9.59 | 140 | 160797 | 8512 | 56122618 |
Folliculitis | 125.43 | 9.59 | 8 | 160929 | 54971 | 56076159 |
Hepatic enzyme increased | 125.08 | 9.59 | 185 | 160752 | 171199 | 55959931 |
Muscle injury | 121.70 | 9.59 | 7 | 160930 | 52493 | 56078637 |
Discomfort | 115.63 | 9.59 | 141 | 160796 | 141620 | 55989510 |
Arthralgia | 114.34 | 9.59 | 903 | 160034 | 500766 | 55630364 |
Peripheral swelling | 113.74 | 9.59 | 321 | 160616 | 234405 | 55896725 |
Hypersensitivity | 109.81 | 9.59 | 371 | 160566 | 256037 | 55875093 |
Drug abuse | 107.28 | 9.59 | 430 | 160507 | 67180 | 56063950 |
Maternal exposure during pregnancy | 106.73 | 9.59 | 240 | 160697 | 189313 | 55941817 |
Rash | 106.62 | 9.59 | 900 | 160037 | 492147 | 55638983 |
Withdrawal syndrome | 104.92 | 9.59 | 189 | 160748 | 18273 | 56112857 |
Impaired healing | 103.17 | 9.59 | 60 | 160877 | 86781 | 56044349 |
Seizure | 101.03 | 9.59 | 658 | 160279 | 124461 | 56006669 |
Irritability | 99.15 | 9.59 | 244 | 160693 | 29344 | 56101786 |
Mania | 98.47 | 9.59 | 142 | 160795 | 11378 | 56119752 |
Fall | 98.22 | 9.59 | 1500 | 159437 | 356010 | 55775120 |
Tardive dyskinesia | 98.15 | 9.59 | 118 | 160819 | 7913 | 56123217 |
Panic attack | 94.84 | 9.59 | 192 | 160745 | 20255 | 56110875 |
Drug hypersensitivity | 92.62 | 9.59 | 438 | 160499 | 274767 | 55856363 |
Stomatitis | 92.48 | 9.59 | 126 | 160811 | 120684 | 56010446 |
Blister | 91.24 | 9.59 | 106 | 160831 | 108781 | 56022349 |
Poisoning deliberate | 89.97 | 9.59 | 126 | 160811 | 9827 | 56121303 |
Infection | 88.90 | 9.59 | 285 | 160652 | 199921 | 55931209 |
Product use issue | 88.19 | 9.59 | 257 | 160680 | 185784 | 55945346 |
Torsade de pointes | 87.44 | 9.59 | 140 | 160797 | 12300 | 56118830 |
Muscle rigidity | 83.24 | 9.59 | 126 | 160811 | 10545 | 56120585 |
Dyskinesia | 83.07 | 9.59 | 226 | 160711 | 28882 | 56102248 |
Mental disorder | 81.59 | 9.59 | 197 | 160740 | 23407 | 56107723 |
Loss of consciousness | 80.43 | 9.59 | 562 | 160375 | 108787 | 56022343 |
Crying | 78.50 | 9.59 | 183 | 160754 | 21257 | 56109873 |
Pain | 77.19 | 9.59 | 1384 | 159553 | 661800 | 55469330 |
Sympathomimetic effect | 76.02 | 9.59 | 20 | 160917 | 38 | 56131092 |
Disturbance in attention | 74.93 | 9.59 | 234 | 160703 | 32306 | 56098824 |
C-reactive protein abnormal | 74.13 | 9.59 | 9 | 160928 | 36800 | 56094330 |
Depressed mood | 72.53 | 9.59 | 249 | 160688 | 36110 | 56095020 |
Long QT syndrome | 71.83 | 9.59 | 64 | 160873 | 3012 | 56128118 |
Mydriasis | 71.60 | 9.59 | 120 | 160817 | 10951 | 56120179 |
Tonsillar ulcer | 70.37 | 9.59 | 28 | 160909 | 273 | 56130857 |
Insomnia | 70.24 | 9.59 | 848 | 160089 | 191012 | 55940118 |
Hyperhidrosis | 70.03 | 9.59 | 485 | 160452 | 93603 | 56037527 |
Toxicity to various agents | 68.96 | 9.59 | 961 | 159976 | 223603 | 55907527 |
Restlessness | 68.59 | 9.59 | 199 | 160738 | 26387 | 56104743 |
Extrapyramidal disorder | 68.31 | 9.59 | 125 | 160812 | 12231 | 56118899 |
Psychotic disorder | 66.32 | 9.59 | 182 | 160755 | 23376 | 56107754 |
Paranoia | 64.93 | 9.59 | 113 | 160824 | 10631 | 56120499 |
Irritable bowel syndrome | 64.84 | 9.59 | 60 | 160877 | 68398 | 56062732 |
Mobility decreased | 64.54 | 9.59 | 115 | 160822 | 98876 | 56032254 |
Dizziness | 63.81 | 9.59 | 1465 | 159472 | 374675 | 55756455 |
Neuroleptic malignant syndrome | 63.31 | 9.59 | 116 | 160821 | 11362 | 56119768 |
Emotional distress | 63.05 | 9.59 | 208 | 160729 | 29555 | 56101575 |
Hallucination, auditory | 62.98 | 9.59 | 116 | 160821 | 11408 | 56119722 |
Febrile neutropenia | 62.37 | 9.59 | 130 | 160807 | 105415 | 56025715 |
Reversible airways obstruction | 61.18 | 9.59 | 42 | 160895 | 1342 | 56129788 |
Bronchial secretion retention | 60.56 | 9.59 | 47 | 160890 | 1821 | 56129309 |
Off label use | 60.17 | 9.59 | 1175 | 159762 | 555005 | 55576125 |
Apathy | 59.34 | 9.59 | 92 | 160845 | 7862 | 56123268 |
Vital capacity decreased | 59.10 | 9.59 | 40 | 160897 | 1248 | 56129882 |
Cholecystitis chronic | 58.23 | 9.59 | 102 | 160835 | 9646 | 56121484 |
Suicidal behaviour | 57.57 | 9.59 | 51 | 160886 | 2382 | 56128748 |
C-reactive protein increased | 57.29 | 9.59 | 85 | 160852 | 78599 | 56052531 |
Stiff person syndrome | 56.46 | 9.59 | 25 | 160912 | 325 | 56130805 |
Hip arthroplasty | 56.28 | 9.59 | 20 | 160917 | 38603 | 56092527 |
Galactorrhoea | 55.60 | 9.59 | 62 | 160875 | 3833 | 56127297 |
Hypertonia | 54.78 | 9.59 | 63 | 160874 | 4029 | 56127101 |
Multiple sclerosis relapse | 54.77 | 9.59 | 264 | 160673 | 44639 | 56086491 |
Reversible cerebral vasoconstriction syndrome | 54.60 | 9.59 | 49 | 160888 | 2328 | 56128802 |
Feeling abnormal | 53.98 | 9.59 | 602 | 160335 | 133000 | 55998130 |
Ill-defined disorder | 53.95 | 9.59 | 70 | 160867 | 68473 | 56062657 |
Drug withdrawal syndrome neonatal | 53.25 | 9.59 | 45 | 160892 | 1971 | 56129159 |
Depressed level of consciousness | 53.21 | 9.59 | 309 | 160628 | 56124 | 56075006 |
Pregnancy | 52.30 | 9.59 | 210 | 160727 | 32823 | 56098307 |
Hallucination, visual | 52.23 | 9.59 | 138 | 160799 | 17330 | 56113800 |
Inflammation | 51.88 | 9.59 | 73 | 160864 | 68998 | 56062132 |
Abnormal behaviour | 50.62 | 9.59 | 150 | 160787 | 20122 | 56111008 |
Knee arthroplasty | 50.57 | 9.59 | 32 | 160905 | 44227 | 56086903 |
Psychomotor hyperactivity | 50.12 | 9.59 | 96 | 160841 | 9724 | 56121406 |
Hyperreflexia | 49.75 | 9.59 | 68 | 160869 | 5182 | 56125948 |
Sepsis | 49.69 | 9.59 | 218 | 160719 | 139622 | 55991508 |
Lower respiratory tract infection viral | 48.59 | 9.59 | 30 | 160907 | 797 | 56130333 |
Sputum culture positive | 48.38 | 9.59 | 40 | 160897 | 1699 | 56129431 |
Death | 48.07 | 9.59 | 687 | 160250 | 340739 | 55790391 |
Aggression | 47.70 | 9.59 | 155 | 160782 | 21851 | 56109279 |
Electrocardiogram QRS complex prolonged | 47.62 | 9.59 | 68 | 160869 | 5399 | 56125731 |
Miosis | 47.44 | 9.59 | 75 | 160862 | 6517 | 56124613 |
Sinusitis | 47.01 | 9.59 | 351 | 160586 | 197230 | 55933900 |
Amnesia | 46.54 | 9.59 | 258 | 160679 | 46064 | 56085066 |
Oculogyric crisis | 46.51 | 9.59 | 37 | 160900 | 1487 | 56129643 |
Pulmonary embolism | 46.18 | 9.59 | 489 | 160448 | 106635 | 56024495 |
Delusion | 45.82 | 9.59 | 100 | 160837 | 11115 | 56120015 |
Hallucination | 45.61 | 9.59 | 268 | 160669 | 48881 | 56082249 |
Drug withdrawal syndrome | 45.52 | 9.59 | 170 | 160767 | 25687 | 56105443 |
Nasopharyngitis | 45.51 | 9.59 | 408 | 160529 | 220551 | 55910579 |
Confusional state | 45.16 | 9.59 | 841 | 160096 | 207314 | 55923816 |
Lip ulceration | 43.80 | 9.59 | 39 | 160898 | 1834 | 56129296 |
Deep vein thrombosis | 42.90 | 9.59 | 371 | 160566 | 76606 | 56054524 |
Bruxism | 42.81 | 9.59 | 49 | 160888 | 3117 | 56128013 |
Sinus bradycardia | 42.33 | 9.59 | 109 | 160828 | 13477 | 56117653 |
Foetal exposure during pregnancy | 42.08 | 9.59 | 200 | 160737 | 33623 | 56097507 |
Congenital absence of vertebra | 41.79 | 9.59 | 12 | 160925 | 36 | 56131094 |
Red blood cell sedimentation rate abnormal | 41.76 | 9.59 | 3 | 160934 | 18670 | 56112460 |
Abnormal dreams | 41.68 | 9.59 | 88 | 160849 | 9561 | 56121569 |
Pyrexia | 41.55 | 9.59 | 897 | 160040 | 417876 | 55713254 |
Musculoskeletal stiffness | 41.10 | 9.59 | 269 | 160668 | 155738 | 55975392 |
Anger | 40.96 | 9.59 | 98 | 160839 | 11574 | 56119556 |
Affective disorder | 40.67 | 9.59 | 64 | 160873 | 5539 | 56125591 |
Memory impairment | 40.58 | 9.59 | 402 | 160535 | 86155 | 56044975 |
Muscle twitching | 40.38 | 9.59 | 120 | 160817 | 16122 | 56115008 |
Arthritis | 39.65 | 9.59 | 149 | 160788 | 99703 | 56031427 |
Syncope | 38.57 | 9.59 | 476 | 160461 | 107723 | 56023407 |
Osteoporosis | 38.11 | 9.59 | 56 | 160881 | 51996 | 56079134 |
Pyramidal tract syndrome | 37.68 | 9.59 | 19 | 160918 | 336 | 56130794 |
Psychomotor retardation | 37.03 | 9.59 | 49 | 160888 | 3620 | 56127510 |
Nightmare | 36.90 | 9.59 | 119 | 160818 | 16707 | 56114423 |
Mental status changes | 36.43 | 9.59 | 207 | 160730 | 37294 | 56093836 |
Cardiac arrest | 36.26 | 9.59 | 392 | 160545 | 85922 | 56045208 |
Dystonia | 36.00 | 9.59 | 97 | 160840 | 12324 | 56118806 |
Clonus | 35.77 | 9.59 | 52 | 160885 | 4197 | 56126933 |
Anhedonia | 35.61 | 9.59 | 84 | 160853 | 9830 | 56121300 |
Depressive symptom | 35.29 | 9.59 | 47 | 160890 | 3494 | 56127636 |
Tachycardia | 35.28 | 9.59 | 460 | 160477 | 105416 | 56025714 |
Adjustment disorder with mixed anxiety and depressed mood | 34.90 | 9.59 | 12 | 160925 | 74 | 56131056 |
Hostility | 34.85 | 9.59 | 34 | 160903 | 1797 | 56129333 |
Bundle branch block left | 34.71 | 9.59 | 64 | 160873 | 6298 | 56124832 |
Acute kidney injury | 34.00 | 9.59 | 484 | 160453 | 240279 | 55890851 |
Neutropenia | 33.90 | 9.59 | 289 | 160648 | 157878 | 55973252 |
Small for dates baby | 33.87 | 9.59 | 46 | 160891 | 3484 | 56127646 |
Major depression | 33.73 | 9.59 | 70 | 160867 | 7514 | 56123616 |
Nausea | 33.59 | 9.59 | 2576 | 158361 | 761602 | 55369528 |
Self-injurious ideation | 32.85 | 9.59 | 37 | 160900 | 2313 | 56128817 |
Libido increased | 32.04 | 9.59 | 28 | 160909 | 1284 | 56129846 |
Slow speech | 31.76 | 9.59 | 28 | 160909 | 1299 | 56129831 |
Generalised tonic-clonic seizure | 31.43 | 9.59 | 159 | 160778 | 27407 | 56103723 |
Subdural hygroma | 31.32 | 9.59 | 15 | 160922 | 236 | 56130894 |
Pneumocystis jirovecii pneumonia | 31.22 | 9.59 | 4 | 160933 | 15697 | 56115433 |
Disorientation | 31.02 | 9.59 | 195 | 160742 | 36418 | 56094712 |
Psoriatic arthropathy | 30.99 | 9.59 | 108 | 160829 | 73900 | 56057230 |
Respiratory arrest | 30.38 | 9.59 | 170 | 160767 | 30455 | 56100675 |
Derealisation | 30.36 | 9.59 | 25 | 160912 | 1056 | 56130074 |
Activation syndrome | 30.31 | 9.59 | 14 | 160923 | 202 | 56130928 |
Fibromyalgia | 29.94 | 9.59 | 80 | 160857 | 59523 | 56071607 |
Optic nerve injury | 29.73 | 9.59 | 19 | 160918 | 537 | 56130593 |
Treatment noncompliance | 29.69 | 9.59 | 177 | 160760 | 32446 | 56098684 |
Alcoholism | 29.55 | 9.59 | 34 | 160903 | 2175 | 56128955 |
Homicidal ideation | 29.35 | 9.59 | 30 | 160907 | 1678 | 56129452 |
Bradyphrenia | 29.32 | 9.59 | 61 | 160876 | 6559 | 56124571 |
Obsessive-compulsive disorder | 29.25 | 9.59 | 44 | 160893 | 3662 | 56127468 |
Skin ulcer | 28.79 | 9.59 | 41 | 160896 | 38567 | 56092563 |
Adverse drug reaction | 28.67 | 9.59 | 93 | 160844 | 65039 | 56066091 |
Gestational diabetes | 28.61 | 9.59 | 68 | 160869 | 7996 | 56123134 |
Cerebral haematoma | 28.46 | 9.59 | 41 | 160896 | 3282 | 56127848 |
Congenital pulmonary valve atresia | 28.26 | 9.59 | 10 | 160927 | 68 | 56131062 |
Head injury | 28.17 | 9.59 | 144 | 160793 | 24922 | 56106208 |
Disease progression | 27.86 | 9.59 | 181 | 160756 | 104992 | 56026138 |
Hypersomnia | 27.58 | 9.59 | 106 | 160831 | 16235 | 56114895 |
Sight disability | 27.31 | 9.59 | 11 | 160926 | 111 | 56131019 |
Intentional product use issue | 27.26 | 9.59 | 170 | 160767 | 99563 | 56031567 |
Thermohypoaesthesia | 27.23 | 9.59 | 11 | 160926 | 112 | 56131018 |
Product administered to patient of inappropriate age | 27.16 | 9.59 | 37 | 160900 | 2811 | 56128319 |
Restless legs syndrome | 27.03 | 9.59 | 108 | 160829 | 16839 | 56114291 |
Rheumatoid nodule | 26.78 | 9.59 | 5 | 160932 | 14852 | 56116278 |
Conversion disorder | 26.76 | 9.59 | 28 | 160909 | 1610 | 56129520 |
Screaming | 26.62 | 9.59 | 38 | 160899 | 3016 | 56128114 |
Euphoric mood | 26.55 | 9.59 | 46 | 160891 | 4312 | 56126818 |
Pancytopenia | 26.49 | 9.59 | 147 | 160790 | 88568 | 56042562 |
Cytomegalovirus infection | 26.44 | 9.59 | 11 | 160926 | 19285 | 56111845 |
Multiple organ dysfunction syndrome | 26.37 | 9.59 | 71 | 160866 | 52699 | 56078431 |
Angle closure glaucoma | 26.24 | 9.59 | 31 | 160906 | 2040 | 56129090 |
Foot deformity | 26.17 | 9.59 | 18 | 160919 | 23807 | 56107323 |
Platelet aggregation inhibition | 26.16 | 9.59 | 11 | 160926 | 125 | 56131005 |
Sinus tachycardia | 25.97 | 9.59 | 130 | 160807 | 22314 | 56108816 |
Morose | 25.90 | 9.59 | 8 | 160929 | 33 | 56131097 |
Mucosal inflammation | 25.90 | 9.59 | 52 | 160885 | 42758 | 56088372 |
Osteoarthritis | 25.67 | 9.59 | 130 | 160807 | 80166 | 56050964 |
Renal impairment | 25.62 | 9.59 | 131 | 160806 | 80582 | 56050548 |
Tongue biting | 25.51 | 9.59 | 25 | 160912 | 1329 | 56129801 |
Nervousness | 25.50 | 9.59 | 156 | 160781 | 28859 | 56102271 |
Initial insomnia | 25.41 | 9.59 | 52 | 160885 | 5527 | 56125603 |
Somnambulism | 25.03 | 9.59 | 49 | 160888 | 5043 | 56126087 |
Sexual dysfunction | 25.01 | 9.59 | 39 | 160898 | 3349 | 56127781 |
Mental impairment | 24.39 | 9.59 | 86 | 160851 | 12636 | 56118494 |
Gun shot wound | 24.31 | 9.59 | 10 | 160927 | 107 | 56131023 |
Bone marrow failure | 24.26 | 9.59 | 27 | 160910 | 28259 | 56102871 |
Gastroschisis | 24.21 | 9.59 | 13 | 160924 | 263 | 56130867 |
Bradycardia | 24.06 | 9.59 | 297 | 160640 | 67207 | 56063923 |
Behaviour disorder | 24.01 | 9.59 | 34 | 160903 | 2679 | 56128451 |
Maternal drugs affecting foetus | 23.82 | 9.59 | 48 | 160889 | 5045 | 56126085 |
Dysarthria | 23.82 | 9.59 | 194 | 160743 | 39356 | 56091774 |
Bipolar disorder | 23.81 | 9.59 | 61 | 160876 | 7519 | 56123611 |
Gastrointestinal disorder | 23.66 | 9.59 | 207 | 160730 | 112495 | 56018635 |
Moaning | 23.53 | 9.59 | 19 | 160918 | 780 | 56130350 |
Dyspnoea | 23.19 | 9.59 | 1423 | 159514 | 591154 | 55539976 |
Sepsis neonatal | 23.16 | 9.59 | 15 | 160922 | 434 | 56130696 |
Ventricular dyskinesia | 23.15 | 9.59 | 10 | 160927 | 122 | 56131008 |
Bone erosion | 23.14 | 9.59 | 7 | 160930 | 14967 | 56116163 |
Psychiatric symptom | 23.07 | 9.59 | 46 | 160891 | 4798 | 56126332 |
Drug screen positive | 23.01 | 9.59 | 38 | 160899 | 3426 | 56127704 |
Blood cholesterol increased | 22.92 | 9.59 | 118 | 160819 | 72461 | 56058669 |
Yawning | 22.80 | 9.59 | 21 | 160916 | 1032 | 56130098 |
Rhabdomyolysis | 22.66 | 9.59 | 196 | 160741 | 40462 | 56090668 |
Hepatic function abnormal | 22.64 | 9.59 | 40 | 160897 | 34518 | 56096612 |
Large intestine anastomosis | 22.64 | 9.59 | 7 | 160930 | 29 | 56131101 |
Libido decreased | 22.53 | 9.59 | 31 | 160906 | 2377 | 56128753 |
Bradypnoea | 22.44 | 9.59 | 36 | 160901 | 3167 | 56127963 |
Multiple sclerosis | 22.27 | 9.59 | 146 | 160791 | 27656 | 56103474 |
Fear | 22.19 | 9.59 | 93 | 160844 | 14815 | 56116315 |
Polydipsia | 22.18 | 9.59 | 36 | 160901 | 3199 | 56127931 |
Extradural haematoma | 22.04 | 9.59 | 25 | 160912 | 1575 | 56129555 |
Myoclonus | 21.98 | 9.59 | 94 | 160843 | 15109 | 56116021 |
Immobilisation prolonged | 21.91 | 9.59 | 9 | 160928 | 96 | 56131034 |
Pruritus | 21.90 | 9.59 | 714 | 160223 | 315909 | 55815221 |
Neutropenic sepsis | 21.89 | 9.59 | 8 | 160929 | 15177 | 56115953 |
Bursitis | 21.87 | 9.59 | 28 | 160909 | 27554 | 56103576 |
Negative thoughts | 21.82 | 9.59 | 19 | 160918 | 867 | 56130263 |
Head banging | 21.71 | 9.59 | 14 | 160923 | 402 | 56130728 |
Intermenstrual bleeding | 21.50 | 9.59 | 56 | 160881 | 6971 | 56124159 |
Panic reaction | 21.49 | 9.59 | 39 | 160898 | 3791 | 56127339 |
Right ventricular dilatation | 21.45 | 9.59 | 21 | 160916 | 1115 | 56130015 |
Hyperthermia | 21.35 | 9.59 | 62 | 160875 | 8223 | 56122907 |
Bundle branch block right | 21.33 | 9.59 | 44 | 160893 | 4703 | 56126427 |
Cardio-respiratory arrest | 21.29 | 9.59 | 247 | 160690 | 55074 | 56076056 |
Dermatitis atopic | 21.29 | 9.59 | 62 | 160875 | 8237 | 56122893 |
Vertigo | 21.16 | 9.59 | 244 | 160693 | 54328 | 56076802 |
Liver injury | 21.14 | 9.59 | 56 | 160881 | 41792 | 56089338 |
Wheezing | 20.96 | 9.59 | 127 | 160810 | 74899 | 56056231 |
Antiphospholipid antibodies | 20.95 | 9.59 | 10 | 160927 | 156 | 56130974 |
Emotional disorder | 20.95 | 9.59 | 80 | 160857 | 12215 | 56118915 |
Post-traumatic neck syndrome | 20.87 | 9.59 | 27 | 160910 | 1951 | 56129179 |
Dysphoria | 20.73 | 9.59 | 44 | 160893 | 4798 | 56126332 |
Paraesthesia | 20.71 | 9.59 | 504 | 160433 | 130010 | 56001120 |
Thinking abnormal | 20.63 | 9.59 | 69 | 160868 | 9872 | 56121258 |
Hypertension | 20.62 | 9.59 | 536 | 160401 | 243742 | 55887388 |
Drowning | 20.54 | 9.59 | 14 | 160923 | 442 | 56130688 |
Postictal state | 20.46 | 9.59 | 19 | 160918 | 944 | 56130186 |
Unresponsive to stimuli | 20.41 | 9.59 | 158 | 160779 | 31567 | 56099563 |
Disseminated intravascular coagulation | 20.33 | 9.59 | 13 | 160924 | 17872 | 56113258 |
Pain in extremity | 20.27 | 9.59 | 672 | 160265 | 296759 | 55834371 |
Red blood cell sedimentation rate increased | 20.07 | 9.59 | 47 | 160890 | 36576 | 56094554 |
Band sensation | 20.01 | 9.59 | 17 | 160920 | 750 | 56130380 |
Therapeutic product effect incomplete | 20.00 | 9.59 | 200 | 160737 | 105831 | 56025299 |
Concussion | 19.63 | 9.59 | 60 | 160877 | 8186 | 56122944 |
Tinnitus | 19.54 | 9.59 | 150 | 160787 | 29892 | 56101238 |
Hypervigilance | 19.53 | 9.59 | 12 | 160925 | 316 | 56130814 |
Platelet count decreased | 19.51 | 9.59 | 202 | 160735 | 106181 | 56024949 |
Serum serotonin | 19.44 | 9.59 | 4 | 160933 | 0 | 56131130 |
Bipolar I disorder | 19.30 | 9.59 | 24 | 160913 | 1666 | 56129464 |
Partner stress | 19.23 | 9.59 | 12 | 160925 | 325 | 56130805 |
Cardiogenic shock | 19.20 | 9.59 | 95 | 160842 | 16230 | 56114900 |
Tracheal atresia | 19.19 | 9.59 | 6 | 160931 | 26 | 56131104 |
Rectal ulcer | 19.17 | 9.59 | 20 | 160917 | 1146 | 56129984 |
Upper-airway cough syndrome | 19.13 | 9.59 | 65 | 160872 | 9373 | 56121757 |
Poisoning | 19.13 | 9.59 | 80 | 160857 | 12733 | 56118397 |
Retinal ischaemia | 19.07 | 9.59 | 12 | 160925 | 330 | 56130800 |
Hypertensive cardiomyopathy | 19.05 | 9.59 | 10 | 160927 | 193 | 56130937 |
Breast swelling | 19.00 | 9.59 | 20 | 160917 | 1158 | 56129972 |
Vision blurred | 18.96 | 9.59 | 338 | 160599 | 82605 | 56048525 |
Musculoskeletal pain | 18.88 | 9.59 | 145 | 160792 | 81007 | 56050123 |
Hepatitis chronic active | 18.80 | 9.59 | 7 | 160930 | 56 | 56131074 |
Blood lactic acid | 18.71 | 9.59 | 8 | 160929 | 95 | 56131035 |
Parkinsonism | 18.70 | 9.59 | 65 | 160872 | 9481 | 56121649 |
Learning disorder | 18.70 | 9.59 | 15 | 160922 | 610 | 56130520 |
Feeling jittery | 18.60 | 9.59 | 76 | 160861 | 11970 | 56119160 |
Retroplacental haematoma | 18.54 | 9.59 | 9 | 160928 | 146 | 56130984 |
Cardiac failure | 18.48 | 9.59 | 148 | 160789 | 81945 | 56049185 |
Panniculitis | 18.42 | 9.59 | 3 | 160934 | 9839 | 56121291 |
Eosinophil count increased | 18.35 | 9.59 | 65 | 160872 | 9572 | 56121558 |
Hyperventilation | 18.31 | 9.59 | 46 | 160891 | 5602 | 56125528 |
Oral candidiasis | 18.29 | 9.59 | 16 | 160921 | 18747 | 56112383 |
Biliary dyskinesia | 18.22 | 9.59 | 29 | 160908 | 2534 | 56128596 |
Atrioventricular block | 18.19 | 9.59 | 52 | 160885 | 6835 | 56124295 |
Heavy menstrual bleeding | 18.13 | 9.59 | 93 | 160844 | 16116 | 56115014 |
Amaurosis | 18.09 | 9.59 | 14 | 160923 | 540 | 56130590 |
Road traffic accident | 17.92 | 9.59 | 139 | 160798 | 27788 | 56103342 |
Balance disorder | 17.91 | 9.59 | 313 | 160624 | 76207 | 56054923 |
Caesarean section | 17.77 | 9.59 | 92 | 160845 | 15999 | 56115131 |
Lethargy | 17.76 | 9.59 | 225 | 160712 | 51216 | 56079914 |
Alcohol abuse | 17.76 | 9.59 | 25 | 160912 | 1959 | 56129171 |
Psychomotor skills impaired | 17.74 | 9.59 | 26 | 160911 | 2114 | 56129016 |
Blood prolactin increased | 17.69 | 9.59 | 33 | 160904 | 3276 | 56127854 |
Ocular hypertension | 17.66 | 9.59 | 17 | 160920 | 884 | 56130246 |
Multiple allergies | 17.64 | 9.59 | 68 | 160869 | 10428 | 56120702 |
Middle insomnia | 17.64 | 9.59 | 70 | 160867 | 10880 | 56120250 |
Feeling of despair | 17.62 | 9.59 | 26 | 160911 | 2127 | 56129003 |
Epilepsy | 17.55 | 9.59 | 128 | 160809 | 25103 | 56106027 |
Acute myocardial infarction | 17.47 | 9.59 | 38 | 160899 | 30355 | 56100775 |
Cytotoxic oedema | 17.36 | 9.59 | 9 | 160928 | 169 | 56130961 |
Hyperdynamic left ventricle | 17.36 | 9.59 | 9 | 160928 | 169 | 56130961 |
Cerebral thrombosis | 17.24 | 9.59 | 22 | 160915 | 1568 | 56129562 |
Drug resistance | 17.19 | 9.59 | 20 | 160917 | 20522 | 56110608 |
Hyperphagia | 17.17 | 9.59 | 22 | 160915 | 1574 | 56129556 |
Uterine perforation | 17.07 | 9.59 | 49 | 160888 | 6456 | 56124674 |
Decreased interest | 17.07 | 9.59 | 31 | 160906 | 3015 | 56128115 |
Pneumonia | 17.06 | 9.59 | 971 | 159966 | 406127 | 55725003 |
Gallbladder disorder | 17.04 | 9.59 | 96 | 160841 | 17238 | 56113892 |
Left ventricle outflow tract obstruction | 17.03 | 9.59 | 10 | 160927 | 242 | 56130888 |
Tearfulness | 17.02 | 9.59 | 35 | 160902 | 3733 | 56127397 |
Substance abuse | 16.98 | 9.59 | 39 | 160898 | 4486 | 56126644 |
Barotrauma | 16.95 | 9.59 | 9 | 160928 | 178 | 56130952 |
Haemoglobin urine | 16.93 | 9.59 | 8 | 160929 | 122 | 56131008 |
Victim of sexual abuse | 16.89 | 9.59 | 14 | 160923 | 597 | 56130533 |
General physical health deterioration | 16.84 | 9.59 | 364 | 160573 | 169646 | 55961484 |
Brain injury | 16.80 | 9.59 | 48 | 160889 | 6307 | 56124823 |
Trunk injury | 16.72 | 9.59 | 5 | 160932 | 18 | 56131112 |
Impulsive behaviour | 16.57 | 9.59 | 21 | 160916 | 1486 | 56129644 |
Blood creatinine increased | 16.51 | 9.59 | 148 | 160789 | 80043 | 56051087 |
Orgasm abnormal | 16.46 | 9.59 | 7 | 160930 | 82 | 56131048 |
Malignant neoplasm progression | 16.41 | 9.59 | 133 | 160804 | 73454 | 56057676 |
Magnetic resonance imaging head abnormal | 16.33 | 9.59 | 23 | 160914 | 1803 | 56129327 |
Product substitution error | 16.31 | 9.59 | 5 | 160932 | 20 | 56131110 |
Macular degeneration | 16.27 | 9.59 | 18 | 160919 | 18890 | 56112240 |
Hepatitis infectious mononucleosis | 16.23 | 9.59 | 7 | 160930 | 85 | 56131045 |
Drug dependence | 16.07 | 9.59 | 115 | 160822 | 22418 | 56108712 |
Ventricular fibrillation | 16.05 | 9.59 | 68 | 160869 | 10884 | 56120246 |
Exercise lack of | 16.03 | 9.59 | 11 | 160926 | 351 | 56130779 |
Femur fracture | 16.01 | 9.59 | 58 | 160879 | 39237 | 56091893 |
Adverse event | 15.86 | 9.59 | 93 | 160844 | 55283 | 56075847 |
Cogwheel rigidity | 15.84 | 9.59 | 23 | 160914 | 1854 | 56129276 |
Soft tissue injury | 15.59 | 9.59 | 21 | 160916 | 1578 | 56129552 |
Hypocoagulable state | 15.55 | 9.59 | 17 | 160920 | 1028 | 56130102 |
Persecutory delusion | 15.49 | 9.59 | 27 | 160910 | 2543 | 56128587 |
Septic shock | 15.45 | 9.59 | 106 | 160831 | 60729 | 56070401 |
Dissociation | 15.37 | 9.59 | 27 | 160910 | 2558 | 56128572 |
Tonsillitis | 15.36 | 9.59 | 41 | 160896 | 5179 | 56125951 |
Swollen tongue | 15.27 | 9.59 | 143 | 160794 | 30181 | 56100949 |
Interstitial lung disease | 15.21 | 9.59 | 98 | 160839 | 56965 | 56074165 |
Disinhibition | 15.17 | 9.59 | 15 | 160922 | 806 | 56130324 |
Congenital diaphragmatic eventration | 15.07 | 9.59 | 4 | 160933 | 8 | 56131122 |
Anti-actin antibody positive | 15.07 | 9.59 | 4 | 160933 | 8 | 56131122 |
Mixed anxiety and depressive disorder | 14.92 | 9.59 | 9 | 160928 | 229 | 56130901 |
Self-medication | 14.82 | 9.59 | 26 | 160911 | 2461 | 56128669 |
Stoma obstruction | 14.74 | 9.59 | 7 | 160930 | 108 | 56131022 |
Transplant rejection | 14.72 | 9.59 | 5 | 160932 | 9929 | 56121201 |
Creatinine renal clearance decreased | 14.70 | 9.59 | 12 | 160925 | 14547 | 56116583 |
Neutrophil count decreased | 14.62 | 9.59 | 83 | 160854 | 49739 | 56081391 |
Respiratory disorder | 14.59 | 9.59 | 49 | 160888 | 33908 | 56097222 |
Drug metabolite level high | 14.58 | 9.59 | 3 | 160934 | 0 | 56131130 |
Obsessive thoughts | 14.55 | 9.59 | 12 | 160925 | 508 | 56130622 |
Alcohol use | 14.52 | 9.59 | 23 | 160914 | 2002 | 56129128 |
Sleep disorder | 14.51 | 9.59 | 273 | 160664 | 67390 | 56063740 |
Haemorrhagic stroke | 14.47 | 9.59 | 41 | 160896 | 5362 | 56125768 |
Hypokalaemia | 14.47 | 9.59 | 363 | 160574 | 94074 | 56037056 |
Osteonecrosis of jaw | 14.42 | 9.59 | 48 | 160889 | 33310 | 56097820 |
Asthma | 14.42 | 9.59 | 231 | 160706 | 112539 | 56018591 |
Prothrombin level increased | 14.41 | 9.59 | 9 | 160928 | 244 | 56130886 |
Cardiac hypertrophy | 14.27 | 9.59 | 16 | 160921 | 995 | 56130135 |
Mood swings | 14.06 | 9.59 | 89 | 160848 | 16658 | 56114472 |
Convulsive threshold lowered | 14.05 | 9.59 | 10 | 160927 | 339 | 56130791 |
Orthostatic hypotension | 14.03 | 9.59 | 151 | 160786 | 33048 | 56098082 |
Carcinoid syndrome | 14.02 | 9.59 | 7 | 160930 | 121 | 56131009 |
Spinal cord oedema | 14.02 | 9.59 | 7 | 160930 | 121 | 56131009 |
Haemophagocytic lymphohistiocytosis | 13.87 | 9.59 | 5 | 160932 | 9567 | 56121563 |
Extensor plantar response | 13.87 | 9.59 | 17 | 160920 | 1163 | 56129967 |
Attention-seeking behaviour | 13.83 | 9.59 | 6 | 160931 | 74 | 56131056 |
Torticollis | 13.83 | 9.59 | 21 | 160916 | 1762 | 56129368 |
Hemianopia | 13.83 | 9.59 | 16 | 160921 | 1030 | 56130100 |
Dissociative disorder | 13.76 | 9.59 | 9 | 160928 | 265 | 56130865 |
Feeling hot | 13.68 | 9.59 | 181 | 160756 | 41606 | 56089524 |
Focal dyscognitive seizures | 13.66 | 9.59 | 27 | 160910 | 2798 | 56128332 |
Staring | 13.59 | 9.59 | 19 | 160918 | 1479 | 56129651 |
Snoring | 13.58 | 9.59 | 31 | 160906 | 3550 | 56127580 |
Fracture | 13.57 | 9.59 | 19 | 160918 | 17999 | 56113131 |
Pulmonary fibrosis | 13.44 | 9.59 | 42 | 160895 | 29716 | 56101414 |
Neonatal tachycardia | 13.25 | 9.59 | 4 | 160933 | 15 | 56131115 |
Transposition of the great vessels | 13.25 | 9.59 | 8 | 160929 | 204 | 56130926 |
Pupil fixed | 13.24 | 9.59 | 20 | 160917 | 1670 | 56129460 |
Suspected suicide | 13.22 | 9.59 | 40 | 160897 | 5426 | 56125704 |
Compulsions | 13.18 | 9.59 | 8 | 160929 | 206 | 56130924 |
Bradykinesia | 13.16 | 9.59 | 37 | 160900 | 4817 | 56126313 |
Post concussion syndrome | 13.15 | 9.59 | 11 | 160926 | 475 | 56130655 |
Cerebellar syndrome | 13.14 | 9.59 | 30 | 160907 | 3437 | 56127693 |
Colour blindness | 13.12 | 9.59 | 9 | 160928 | 287 | 56130843 |
Apnoea | 13.07 | 9.59 | 48 | 160889 | 7194 | 56123936 |
Bundle branch block | 13.06 | 9.59 | 14 | 160923 | 828 | 56130302 |
Stoma site discharge | 13.05 | 9.59 | 18 | 160919 | 1384 | 56129746 |
Flight of ideas | 12.94 | 9.59 | 10 | 160927 | 385 | 56130745 |
Hypomania | 12.94 | 9.59 | 37 | 160900 | 4865 | 56126265 |
Joint hyperextension | 12.93 | 9.59 | 9 | 160928 | 294 | 56130836 |
Superior sagittal sinus thrombosis | 12.91 | 9.59 | 13 | 160924 | 714 | 56130416 |
Neonatal anuria | 12.82 | 9.59 | 5 | 160932 | 46 | 56131084 |
Narrow anterior chamber angle | 12.82 | 9.59 | 5 | 160932 | 46 | 56131084 |
Haematotoxicity | 12.81 | 9.59 | 4 | 160933 | 8379 | 56122751 |
Illusion | 12.80 | 9.59 | 15 | 160922 | 979 | 56130151 |
Nuchal rigidity | 12.79 | 9.59 | 12 | 160925 | 604 | 56130526 |
Sebaceous gland infection | 12.72 | 9.59 | 7 | 160930 | 149 | 56130981 |
Sedation | 12.70 | 9.59 | 154 | 160783 | 34700 | 56096430 |
Pulmonary contusion | 12.67 | 9.59 | 4 | 160933 | 18 | 56131112 |
Sternal fracture | 12.65 | 9.59 | 22 | 160915 | 2068 | 56129062 |
Lip dry | 12.64 | 9.59 | 6 | 160931 | 9734 | 56121396 |
Weight increased | 12.56 | 9.59 | 789 | 160148 | 228914 | 55902216 |
Metamyelocyte count increased | 12.52 | 9.59 | 8 | 160929 | 226 | 56130904 |
Wrong product procured | 12.51 | 9.59 | 3 | 160934 | 3 | 56131127 |
Cerebral arteriovenous malformation haemorrhagic | 12.51 | 9.59 | 3 | 160934 | 3 | 56131127 |
Mood altered | 12.50 | 9.59 | 73 | 160864 | 13282 | 56117848 |
Essential tremor | 12.45 | 9.59 | 15 | 160922 | 1008 | 56130122 |
Colitis microscopic | 12.41 | 9.59 | 50 | 160887 | 7825 | 56123305 |
Diplopia | 12.31 | 9.59 | 100 | 160837 | 20269 | 56110861 |
Poor quality sleep | 12.31 | 9.59 | 90 | 160847 | 17665 | 56113465 |
Social avoidant behaviour | 12.31 | 9.59 | 26 | 160911 | 2826 | 56128304 |
Blunted affect | 12.27 | 9.59 | 8 | 160929 | 234 | 56130896 |
Multimorbidity | 12.27 | 9.59 | 11 | 160926 | 522 | 56130608 |
Anxiety disorder | 12.26 | 9.59 | 31 | 160906 | 3789 | 56127341 |
Psychotic disorder due to a general medical condition | 12.24 | 9.59 | 8 | 160929 | 235 | 56130895 |
Aphasia | 12.24 | 9.59 | 137 | 160800 | 30278 | 56100852 |
Exposure via breast milk | 12.20 | 9.59 | 20 | 160917 | 1792 | 56129338 |
Hypotension | 12.19 | 9.59 | 852 | 160085 | 249656 | 55881474 |
Therapeutic response unexpected | 12.16 | 9.59 | 87 | 160850 | 16957 | 56114173 |
Coma scale abnormal | 12.16 | 9.59 | 36 | 160901 | 4827 | 56126303 |
Mucosal ulceration | 12.15 | 9.59 | 14 | 160923 | 897 | 56130233 |
Sputum culture | 12.12 | 9.59 | 7 | 160930 | 164 | 56130966 |
Blood pressure diastolic decreased | 12.09 | 9.59 | 23 | 160914 | 19300 | 56111830 |
Anterograde amnesia | 12.07 | 9.59 | 11 | 160926 | 533 | 56130597 |
Constricted affect | 12.05 | 9.59 | 3 | 160934 | 4 | 56131126 |
Retching | 12.05 | 9.59 | 73 | 160864 | 13457 | 56117673 |
Logorrhoea | 12.01 | 9.59 | 23 | 160914 | 2329 | 56128801 |
Gambling disorder | 11.95 | 9.59 | 16 | 160921 | 1195 | 56129935 |
Flat affect | 11.95 | 9.59 | 17 | 160920 | 1345 | 56129785 |
Myocardial infarction | 11.95 | 9.59 | 190 | 160747 | 92680 | 56038450 |
Impaired driving ability | 11.88 | 9.59 | 32 | 160905 | 4064 | 56127066 |
Holoprosencephaly | 11.87 | 9.59 | 4 | 160933 | 23 | 56131107 |
Sleep-related eating disorder | 11.82 | 9.59 | 13 | 160924 | 791 | 56130339 |
Ovarian vein thrombosis | 11.80 | 9.59 | 5 | 160932 | 58 | 56131072 |
Sleep talking | 11.71 | 9.59 | 14 | 160923 | 933 | 56130197 |
Acute myeloid leukaemia | 11.71 | 9.59 | 19 | 160918 | 16953 | 56114177 |
Neuromyelitis optica spectrum disorder | 11.69 | 9.59 | 15 | 160922 | 1075 | 56130055 |
Laryngectomy | 11.59 | 9.59 | 4 | 160933 | 25 | 56131105 |
Cellulitis | 11.52 | 9.59 | 148 | 160789 | 74801 | 56056329 |
Enterococcus test positive | 11.52 | 9.59 | 15 | 160922 | 1091 | 56130039 |
Creatinine urine decreased | 11.51 | 9.59 | 7 | 160930 | 181 | 56130949 |
Skin necrosis | 11.50 | 9.59 | 11 | 160926 | 12350 | 56118780 |
Gastrointestinal procedural complication | 11.47 | 9.59 | 7 | 160930 | 182 | 56130948 |
Haematoma | 11.46 | 9.59 | 141 | 160796 | 31878 | 56099252 |
Choroidal effusion | 11.45 | 9.59 | 10 | 160927 | 458 | 56130672 |
Migraine | 11.40 | 9.59 | 327 | 160610 | 86470 | 56044660 |
Pulseless electrical activity | 11.39 | 9.59 | 45 | 160892 | 6979 | 56124151 |
Tonic clonic movements | 11.36 | 9.59 | 16 | 160921 | 1254 | 56129876 |
Atrophy of globe | 11.30 | 9.59 | 3 | 160934 | 6 | 56131124 |
Wound healing normal | 11.30 | 9.59 | 3 | 160934 | 6 | 56131124 |
Meningocele | 11.30 | 9.59 | 3 | 160934 | 6 | 56131124 |
Respiratory tract infection | 11.29 | 9.59 | 155 | 160782 | 35916 | 56095214 |
Neonatal respiratory depression | 11.29 | 9.59 | 5 | 160932 | 65 | 56131065 |
Cyanosis neonatal | 11.24 | 9.59 | 8 | 160929 | 271 | 56130859 |
Tachyphrenia | 11.23 | 9.59 | 16 | 160921 | 1268 | 56129862 |
Hypernatraemia | 11.22 | 9.59 | 43 | 160894 | 6577 | 56124553 |
Anaemia | 11.20 | 9.59 | 638 | 160299 | 266873 | 55864257 |
Antipsychotic drug level increased | 11.14 | 9.59 | 27 | 160910 | 3215 | 56127915 |
Compulsive shopping | 11.12 | 9.59 | 12 | 160925 | 715 | 56130415 |
Cor pulmonale acute | 11.12 | 9.59 | 9 | 160928 | 371 | 56130759 |
Dry mouth | 11.12 | 9.59 | 251 | 160686 | 63954 | 56067176 |
Cyclic vomiting syndrome | 11.09 | 9.59 | 5 | 160932 | 68 | 56131062 |
Dextrocardia | 11.08 | 9.59 | 4 | 160933 | 29 | 56131101 |
Headache | 11.07 | 9.59 | 1789 | 159148 | 557255 | 55573875 |
Stress | 11.06 | 9.59 | 233 | 160704 | 58677 | 56072453 |
Incoherent | 11.05 | 9.59 | 32 | 160905 | 4237 | 56126893 |
Lung diffusion disorder | 10.96 | 9.59 | 5 | 160932 | 70 | 56131060 |
Impaired gastric emptying | 10.96 | 9.59 | 54 | 160883 | 9209 | 56121921 |
Periorbital haemorrhage | 10.90 | 9.59 | 5 | 160932 | 71 | 56131059 |
Menometrorrhagia | 10.89 | 9.59 | 13 | 160924 | 865 | 56130265 |
Bile acid malabsorption | 10.89 | 9.59 | 7 | 160930 | 200 | 56130930 |
Subdural haematoma | 10.88 | 9.59 | 71 | 160866 | 13428 | 56117702 |
Cluster headache | 10.75 | 9.59 | 11 | 160926 | 616 | 56130514 |
Oedema | 10.74 | 9.59 | 167 | 160770 | 81753 | 56049377 |
CSF pressure increased | 10.73 | 9.59 | 6 | 160931 | 132 | 56130998 |
Metastases to bone | 10.72 | 9.59 | 25 | 160912 | 19483 | 56111647 |
Mitochondrial myopathy | 10.59 | 9.59 | 5 | 160932 | 76 | 56131054 |
Electrocardiogram P wave abnormal | 10.58 | 9.59 | 7 | 160930 | 210 | 56130920 |
Bone swelling | 10.58 | 9.59 | 17 | 160920 | 1498 | 56129632 |
Hypotonia | 10.57 | 9.59 | 51 | 160886 | 8626 | 56122504 |
Peripheral venous disease | 10.57 | 9.59 | 8 | 160929 | 10071 | 56121059 |
Coordination abnormal | 10.55 | 9.59 | 67 | 160870 | 12554 | 56118576 |
Catatonia | 10.54 | 9.59 | 30 | 160907 | 3934 | 56127196 |
White blood cell count decreased | 10.47 | 9.59 | 277 | 160660 | 125713 | 56005417 |
Apallic syndrome | 10.45 | 9.59 | 11 | 160926 | 637 | 56130493 |
Ejection fraction decreased | 10.45 | 9.59 | 26 | 160911 | 19815 | 56111315 |
Optic atrophy | 10.41 | 9.59 | 15 | 160922 | 1201 | 56129929 |
Polyarthritis | 10.40 | 9.59 | 6 | 160931 | 8722 | 56122408 |
Bronchial hyperreactivity | 10.39 | 9.59 | 17 | 160920 | 1520 | 56129610 |
Sialoadenitis | 10.39 | 9.59 | 17 | 160920 | 1521 | 56129609 |
Oesophageal atresia | 10.39 | 9.59 | 10 | 160927 | 520 | 56130610 |
Amenorrhoea | 10.36 | 9.59 | 52 | 160885 | 8934 | 56122196 |
Pancreatic carcinoma recurrent | 10.31 | 9.59 | 5 | 160932 | 81 | 56131049 |
Finger deformity | 10.30 | 9.59 | 3 | 160934 | 6574 | 56124556 |
Biliary colic | 10.30 | 9.59 | 27 | 160910 | 3375 | 56127755 |
Housebound | 10.27 | 9.59 | 7 | 160930 | 221 | 56130909 |
Endometrial disorder | 10.24 | 9.59 | 11 | 160926 | 652 | 56130478 |
Congenital tracheomalacia | 10.24 | 9.59 | 4 | 160933 | 37 | 56131093 |
Sluggishness | 10.22 | 9.59 | 33 | 160904 | 4635 | 56126495 |
Convulsions local | 10.21 | 9.59 | 3 | 160934 | 10 | 56131120 |
Fatigue | 10.18 | 9.59 | 2045 | 158892 | 786507 | 55344623 |
Head titubation | 10.17 | 9.59 | 12 | 160925 | 789 | 56130341 |
Speech disorder | 10.12 | 9.59 | 157 | 160780 | 37336 | 56093794 |
Belligerence | 10.11 | 9.59 | 6 | 160931 | 148 | 56130982 |
Live birth | 10.08 | 9.59 | 26 | 160911 | 19579 | 56111551 |
Urinary incontinence | 10.04 | 9.59 | 129 | 160808 | 29456 | 56101674 |
Device placement issue | 10.02 | 9.59 | 13 | 160924 | 942 | 56130188 |
Tic | 9.90 | 9.59 | 15 | 160922 | 1256 | 56129874 |
Movement disorder | 9.90 | 9.59 | 91 | 160846 | 19107 | 56112023 |
Sputum discoloured | 9.86 | 9.59 | 16 | 160921 | 14276 | 56116854 |
Anorgasmia | 9.85 | 9.59 | 10 | 160927 | 555 | 56130575 |
Hot flush | 9.83 | 9.59 | 188 | 160749 | 46538 | 56084592 |
Basilar migraine | 9.79 | 9.59 | 4 | 160933 | 42 | 56131088 |
Neoplasm malignant | 9.71 | 9.59 | 42 | 160895 | 27013 | 56104117 |
Angina pectoris | 9.69 | 9.59 | 44 | 160893 | 27932 | 56103198 |
Electrocardiogram U wave present | 9.69 | 9.59 | 5 | 160932 | 93 | 56131037 |
Gallbladder injury | 9.65 | 9.59 | 15 | 160922 | 1285 | 56129845 |
Hepatotoxicity | 9.64 | 9.59 | 51 | 160886 | 31102 | 56100028 |
Emotional poverty | 9.63 | 9.59 | 8 | 160929 | 342 | 56130788 |
Inappropriate affect | 9.61 | 9.59 | 12 | 160925 | 837 | 56130293 |
Pneumoconiosis | 9.60 | 9.59 | 3 | 160934 | 13 | 56131117 |
Pulmonary arterial hypertension | 9.60 | 9.59 | 41 | 160896 | 26462 | 56104668 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Serotonin syndrome | 432.58 | 10.32 | 352 | 72049 | 18421 | 31606522 |
Completed suicide | 301.23 | 10.32 | 653 | 71748 | 90861 | 31534082 |
Suicidal ideation | 301.19 | 10.32 | 393 | 72008 | 36013 | 31588930 |
Suicide attempt | 269.89 | 10.32 | 377 | 72024 | 36871 | 31588072 |
Intentional overdose | 242.35 | 10.32 | 379 | 72022 | 41010 | 31583933 |
Depression | 228.91 | 10.32 | 584 | 71817 | 90231 | 31534712 |
Anxiety | 213.65 | 10.32 | 570 | 71831 | 90463 | 31534480 |
Agitation | 191.26 | 10.32 | 398 | 72003 | 53771 | 31571172 |
Aggression | 145.88 | 10.32 | 286 | 72115 | 37005 | 31587938 |
Somnolence | 135.94 | 10.32 | 517 | 71884 | 98928 | 31526015 |
Intentional self-injury | 129.58 | 10.32 | 156 | 72245 | 13159 | 31611784 |
Tremor | 121.11 | 10.32 | 417 | 71984 | 76003 | 31548940 |
Foetal exposure during pregnancy | 115.66 | 10.32 | 275 | 72126 | 40601 | 31584342 |
Sopor | 102.18 | 10.32 | 129 | 72272 | 11423 | 31613520 |
Overdose | 97.93 | 10.32 | 418 | 71983 | 84246 | 31540697 |
Withdrawal syndrome | 96.04 | 10.32 | 126 | 72275 | 11591 | 31613352 |
Electrocardiogram QT prolonged | 93.16 | 10.32 | 242 | 72159 | 37745 | 31587198 |
Paranoia | 91.98 | 10.32 | 117 | 72284 | 10438 | 31614505 |
Mania | 91.72 | 10.32 | 109 | 72292 | 9068 | 31615875 |
Poisoning deliberate | 88.29 | 10.32 | 96 | 72305 | 7248 | 31617695 |
Intrusive thoughts | 84.96 | 10.32 | 30 | 72371 | 261 | 31624682 |
Sexual dysfunction | 84.24 | 10.32 | 85 | 72316 | 5883 | 31619060 |
Drug interaction | 82.65 | 10.32 | 782 | 71619 | 207761 | 31417182 |
Disturbance in attention | 80.37 | 10.32 | 166 | 72235 | 22284 | 31602659 |
Major depression | 77.98 | 10.32 | 70 | 72331 | 4183 | 31620760 |
Febrile neutropenia | 74.15 | 10.32 | 102 | 72299 | 121747 | 31503196 |
Sedation | 73.57 | 10.32 | 145 | 72256 | 18820 | 31606123 |
Insomnia | 73.01 | 10.32 | 417 | 71984 | 94419 | 31530524 |
Muscle rigidity | 68.39 | 10.32 | 98 | 72303 | 9799 | 31615144 |
Coma | 68.16 | 10.32 | 228 | 72173 | 40922 | 31584021 |
Maternal drugs affecting foetus | 67.18 | 10.32 | 62 | 72339 | 3841 | 31621102 |
Loss of libido | 66.12 | 10.32 | 50 | 72351 | 2345 | 31622598 |
Confusional state | 65.23 | 10.32 | 524 | 71877 | 132810 | 31492133 |
Drug withdrawal syndrome | 65.19 | 10.32 | 137 | 72264 | 18613 | 31606330 |
Fall | 65.02 | 10.32 | 680 | 71721 | 185409 | 31439534 |
Irritability | 64.72 | 10.32 | 154 | 72247 | 22735 | 31602208 |
Restlessness | 63.72 | 10.32 | 155 | 72246 | 23206 | 31601737 |
Dyskinesia | 62.74 | 10.32 | 144 | 72257 | 20766 | 31604177 |
Anger | 60.90 | 10.32 | 99 | 72302 | 11054 | 31613889 |
Panic attack | 56.97 | 10.32 | 84 | 72317 | 8619 | 31616324 |
Activation syndrome | 56.67 | 10.32 | 17 | 72384 | 82 | 31624861 |
Tachyphrenia | 56.44 | 10.32 | 35 | 72366 | 1182 | 31623761 |
Erectile dysfunction | 56.10 | 10.32 | 131 | 72270 | 19104 | 31605839 |
Interstitial lung disease | 55.37 | 10.32 | 36 | 72365 | 61367 | 31563576 |
Thrombocytopenia | 53.78 | 10.32 | 158 | 72243 | 142589 | 31482354 |
Pyrexia | 53.49 | 10.32 | 441 | 71960 | 303399 | 31321544 |
Hyperhidrosis | 52.93 | 10.32 | 298 | 72103 | 67095 | 31557848 |
Septic shock | 52.90 | 10.32 | 44 | 72357 | 66114 | 31558829 |
Neutropenia | 52.42 | 10.32 | 156 | 72245 | 140208 | 31484735 |
Apathy | 52.02 | 10.32 | 69 | 72332 | 6413 | 31618530 |
Mood swings | 52.01 | 10.32 | 74 | 72327 | 7350 | 31617593 |
Rheumatoid arthritis | 52.01 | 10.32 | 22 | 72379 | 47787 | 31577156 |
Hypomania | 51.63 | 10.32 | 42 | 72359 | 2193 | 31622750 |
Mycotic allergy | 50.84 | 10.32 | 22 | 72379 | 343 | 31624600 |
Product substitution issue | 50.52 | 10.32 | 83 | 72318 | 9349 | 31615594 |
Pneumonia | 50.21 | 10.32 | 507 | 71894 | 334805 | 31290138 |
Homicidal ideation | 50.20 | 10.32 | 44 | 72357 | 2547 | 31622396 |
Libido decreased | 49.89 | 10.32 | 56 | 72345 | 4380 | 31620563 |
Hallucination | 49.69 | 10.32 | 224 | 72177 | 46186 | 31578757 |
Akathisia | 48.91 | 10.32 | 71 | 72330 | 7182 | 31617761 |
Renal impairment | 48.86 | 10.32 | 76 | 72325 | 86273 | 31538670 |
Mite allergy | 47.73 | 10.32 | 22 | 72379 | 401 | 31624542 |
Hallucination, visual | 47.64 | 10.32 | 109 | 72292 | 15685 | 31609258 |
Anorgasmia | 46.76 | 10.32 | 26 | 72375 | 714 | 31624229 |
Drug withdrawal syndrome neonatal | 46.14 | 10.32 | 48 | 72353 | 3444 | 31621499 |
Sepsis | 45.84 | 10.32 | 185 | 72216 | 151744 | 31473199 |
Bipolar disorder | 45.32 | 10.32 | 49 | 72352 | 3675 | 31621268 |
Spirometry abnormal | 45.30 | 10.32 | 22 | 72379 | 453 | 31624490 |
Gun shot wound | 44.60 | 10.32 | 29 | 72372 | 1065 | 31623878 |
Hallucination, auditory | 43.60 | 10.32 | 82 | 72319 | 10278 | 31614665 |
Tardive dyskinesia | 42.82 | 10.32 | 58 | 72343 | 5501 | 31619442 |
Abulia | 42.70 | 10.32 | 22 | 72379 | 516 | 31624427 |
Parkinsonism | 41.98 | 10.32 | 68 | 72333 | 7568 | 31617375 |
Mydriasis | 41.11 | 10.32 | 62 | 72339 | 6490 | 31618453 |
Chest injury | 41.04 | 10.32 | 31 | 72370 | 1451 | 31623492 |
Sleep disorder | 40.99 | 10.32 | 143 | 72258 | 26205 | 31598738 |
Dust allergy | 40.83 | 10.32 | 22 | 72379 | 567 | 31624376 |
Respiratory disorder neonatal | 40.80 | 10.32 | 31 | 72370 | 1464 | 31623479 |
Malignant neoplasm progression | 40.56 | 10.32 | 74 | 72327 | 78924 | 31546019 |
Multiple organ dysfunction syndrome | 40.55 | 10.32 | 58 | 72343 | 68145 | 31556798 |
Conjunctivitis allergic | 40.54 | 10.32 | 24 | 72377 | 744 | 31624199 |
Depressed mood | 40.06 | 10.32 | 109 | 72292 | 17466 | 31607477 |
Renal failure | 39.87 | 10.32 | 146 | 72255 | 123184 | 31501759 |
Catatonia | 39.80 | 10.32 | 52 | 72349 | 4762 | 31620181 |
Hyperreflexia | 39.80 | 10.32 | 41 | 72360 | 2908 | 31622035 |
Infusion related reaction | 39.61 | 10.32 | 31 | 72370 | 48024 | 31576919 |
Amnesia | 39.03 | 10.32 | 130 | 72271 | 23272 | 31601671 |
Acute kidney injury | 38.94 | 10.32 | 430 | 71971 | 279284 | 31345659 |
Neuroleptic malignant syndrome | 38.82 | 10.32 | 105 | 72296 | 16764 | 31608179 |
Memory impairment | 38.56 | 10.32 | 181 | 72220 | 37949 | 31586994 |
Anaemia | 37.91 | 10.32 | 309 | 72092 | 213213 | 31411730 |
Abnormal behaviour | 35.93 | 10.32 | 128 | 72273 | 23700 | 31601243 |
Foetal malformation | 35.67 | 10.32 | 13 | 72388 | 125 | 31624818 |
Alcoholism | 35 | 10.32 | 41 | 72360 | 3358 | 31621585 |
Impulsive behaviour | 34.69 | 10.32 | 32 | 72369 | 1981 | 31622962 |
Homicide | 33.87 | 10.32 | 23 | 72378 | 909 | 31624034 |
Social avoidant behaviour | 33.82 | 10.32 | 38 | 72363 | 2975 | 31621968 |
Bone marrow failure | 33.63 | 10.32 | 11 | 72390 | 27997 | 31596946 |
Myoclonus | 33.12 | 10.32 | 88 | 72313 | 13902 | 31611041 |
Resting tremor | 33.05 | 10.32 | 20 | 72381 | 646 | 31624297 |
Extrapyramidal disorder | 33.02 | 10.32 | 79 | 72322 | 11699 | 31613244 |
Feeling abnormal | 32.87 | 10.32 | 233 | 72168 | 56769 | 31568174 |
Small for dates baby | 32.61 | 10.32 | 41 | 72360 | 3614 | 31621329 |
Clonus | 32.16 | 10.32 | 34 | 72367 | 2485 | 31622458 |
Electrocardiogram QT interval | 31.97 | 10.32 | 9 | 72392 | 33 | 31624910 |
Anencephaly | 31.91 | 10.32 | 12 | 72389 | 127 | 31624816 |
Psychotic disorder | 31.28 | 10.32 | 117 | 72284 | 22176 | 31602767 |
Painful respiration | 30.96 | 10.32 | 24 | 72377 | 1168 | 31623775 |
Seizure | 30.81 | 10.32 | 356 | 72045 | 99412 | 31525531 |
Skin dystrophy | 30.75 | 10.32 | 7 | 72394 | 7 | 31624936 |
Walking aid user | 30.14 | 10.32 | 27 | 72374 | 1609 | 31623334 |
Delusion | 29.97 | 10.32 | 77 | 72324 | 11920 | 31613023 |
Depressive symptom | 29.63 | 10.32 | 30 | 72371 | 2084 | 31622859 |
Loss of consciousness | 29.48 | 10.32 | 288 | 72113 | 77067 | 31547876 |
Electrocardiogram QRS complex prolonged | 29.40 | 10.32 | 42 | 72359 | 4187 | 31620756 |
Postural orthostatic tachycardia syndrome | 29.10 | 10.32 | 9 | 72392 | 49 | 31624894 |
Reduced facial expression | 28.72 | 10.32 | 20 | 72381 | 824 | 31624119 |
Persecutory delusion | 28.71 | 10.32 | 31 | 72370 | 2321 | 31622622 |
Lactic acidosis | 28.41 | 10.32 | 19 | 72382 | 31918 | 31593025 |
Prescribed overdose | 28.34 | 10.32 | 64 | 72337 | 9128 | 31615815 |
Cardiac failure | 28.26 | 10.32 | 101 | 72300 | 85852 | 31539091 |
Cerebral haematoma | 28.16 | 10.32 | 42 | 72359 | 4353 | 31620590 |
Consciousness fluctuating | 28.06 | 10.32 | 22 | 72379 | 1089 | 31623854 |
Drug screen positive | 27.88 | 10.32 | 39 | 72362 | 3813 | 31621130 |
Blood creatinine increased | 27.77 | 10.32 | 107 | 72294 | 88971 | 31535972 |
Dyspnoea | 27.54 | 10.32 | 587 | 71814 | 342892 | 31282051 |
Congenital ureteropelvic junction obstruction | 27.44 | 10.32 | 9 | 72392 | 61 | 31624882 |
Alcohol use | 27.42 | 10.32 | 35 | 72366 | 3132 | 31621811 |
Cogwheel rigidity | 27.06 | 10.32 | 23 | 72378 | 1277 | 31623666 |
Craniosynostosis | 27.00 | 10.32 | 14 | 72387 | 333 | 31624610 |
Device dislocation | 26.98 | 10.32 | 45 | 72356 | 5131 | 31619812 |
Psychomotor hyperactivity | 26.89 | 10.32 | 61 | 72340 | 8726 | 31616217 |
Self esteem decreased | 26.88 | 10.32 | 16 | 72385 | 501 | 31624442 |
Hyperthermia | 26.87 | 10.32 | 66 | 72335 | 9938 | 31615005 |
Off label use | 26.83 | 10.32 | 597 | 71804 | 346677 | 31278266 |
Emotional disorder | 26.52 | 10.32 | 45 | 72356 | 5204 | 31619739 |
Cognitive disorder | 26.44 | 10.32 | 120 | 72281 | 24803 | 31600140 |
Reversible cerebral vasoconstriction syndrome | 26.44 | 10.32 | 14 | 72387 | 348 | 31624595 |
Disorientation | 26.16 | 10.32 | 139 | 72262 | 30605 | 31594338 |
Delirium | 26.06 | 10.32 | 173 | 72228 | 41248 | 31583695 |
Trisomy 18 | 25.97 | 10.32 | 14 | 72387 | 361 | 31624582 |
Platelet count decreased | 25.95 | 10.32 | 147 | 72254 | 110288 | 31514655 |
Psychomotor retardation | 25.15 | 10.32 | 34 | 72367 | 3218 | 31621725 |
Mental disorder | 25.00 | 10.32 | 79 | 72322 | 13755 | 31611188 |
Infantile apnoea | 24.68 | 10.32 | 19 | 72382 | 915 | 31624028 |
Bruxism | 24.45 | 10.32 | 24 | 72377 | 1606 | 31623337 |
Poor quality sleep | 24.28 | 10.32 | 54 | 72347 | 7624 | 31617319 |
Depressed level of consciousness | 24.15 | 10.32 | 161 | 72240 | 38440 | 31586503 |
Libido increased | 24.02 | 10.32 | 17 | 72384 | 719 | 31624224 |
Urinary retention | 23.78 | 10.32 | 145 | 72256 | 33580 | 31591363 |
Torsade de pointes | 23.74 | 10.32 | 50 | 72351 | 6800 | 31618143 |
Apraxia | 23.53 | 10.32 | 21 | 72380 | 1245 | 31623698 |
Bradypnoea | 23.41 | 10.32 | 29 | 72372 | 2518 | 31622425 |
Anhedonia | 23.15 | 10.32 | 52 | 72349 | 7390 | 31617553 |
Cardiac failure congestive | 23.07 | 10.32 | 98 | 72303 | 79289 | 31545654 |
Gambling disorder | 22.94 | 10.32 | 23 | 72378 | 1579 | 31623364 |
Derealisation | 22.61 | 10.32 | 15 | 72386 | 570 | 31624373 |
Orthostatic hypotension | 22.58 | 10.32 | 112 | 72289 | 24007 | 31600936 |
Priapism | 22.54 | 10.32 | 39 | 72362 | 4581 | 31620362 |
Toxic encephalopathy | 22.44 | 10.32 | 40 | 72361 | 4810 | 31620133 |
Legal problem | 22.33 | 10.32 | 10 | 72391 | 170 | 31624773 |
Feeling guilty | 22.28 | 10.32 | 12 | 72389 | 309 | 31624634 |
Agitation neonatal | 22.21 | 10.32 | 19 | 72382 | 1064 | 31623879 |
Gynaecomastia | 22.09 | 10.32 | 58 | 72343 | 9096 | 31615847 |
Inhibitory drug interaction | 21.83 | 10.32 | 22 | 72379 | 1520 | 31623423 |
Orgasm abnormal | 21.80 | 10.32 | 9 | 72392 | 124 | 31624819 |
Respiratory failure | 21.74 | 10.32 | 139 | 72262 | 101310 | 31523633 |
Neonatal pneumonia | 21.67 | 10.32 | 9 | 72392 | 126 | 31624817 |
Cytomegalovirus infection | 21.57 | 10.32 | 15 | 72386 | 24692 | 31600251 |
Pregnancy | 21.51 | 10.32 | 11 | 72390 | 254 | 31624689 |
Hypersomnia | 21.49 | 10.32 | 65 | 72336 | 11054 | 31613889 |
Disseminated intravascular coagulation | 21.46 | 10.32 | 10 | 72391 | 20527 | 31604416 |
Ascites | 21.41 | 10.32 | 38 | 72363 | 40975 | 31583968 |
Negative thoughts | 21.41 | 10.32 | 15 | 72386 | 624 | 31624319 |
Total lung capacity abnormal | 21.36 | 10.32 | 9 | 72392 | 131 | 31624812 |
Gastrointestinal hypermotility | 21.30 | 10.32 | 9 | 72392 | 132 | 31624811 |
Neonatal respiratory distress | 21.27 | 10.32 | 14 | 72387 | 525 | 31624418 |
Bronchopulmonary aspergillosis | 21.13 | 10.32 | 3 | 72398 | 13631 | 31611312 |
Burnout syndrome | 20.82 | 10.32 | 9 | 72392 | 140 | 31624803 |
Crying | 20.75 | 10.32 | 42 | 72359 | 5555 | 31619388 |
Obsessive-compulsive disorder | 20.67 | 10.32 | 39 | 72362 | 4898 | 31620045 |
Disinhibition | 20.59 | 10.32 | 28 | 72373 | 2665 | 31622278 |
Congenital hearing disorder | 20.52 | 10.32 | 8 | 72393 | 94 | 31624849 |
Electrocardiogram QT interval abnormal | 20.52 | 10.32 | 8 | 72393 | 94 | 31624849 |
Tension | 20.38 | 10.32 | 24 | 72377 | 1977 | 31622966 |
Abnormal dreams | 20.27 | 10.32 | 48 | 72353 | 7060 | 31617883 |
Rash | 20.24 | 10.32 | 331 | 72070 | 201155 | 31423788 |
Stomatitis | 20.18 | 10.32 | 37 | 72364 | 39401 | 31585542 |
Judgement impaired | 20.05 | 10.32 | 14 | 72387 | 579 | 31624364 |
Pruritus | 20.01 | 10.32 | 186 | 72215 | 124981 | 31499962 |
Persistent depressive disorder | 19.85 | 10.32 | 11 | 72390 | 300 | 31624643 |
Parkinsonian gait | 19.76 | 10.32 | 13 | 72388 | 487 | 31624456 |
Death | 19.71 | 10.32 | 651 | 71750 | 359918 | 31265025 |
Ejaculation disorder | 19.56 | 10.32 | 17 | 72384 | 973 | 31623970 |
Myelosuppression | 19.49 | 10.32 | 5 | 72396 | 14915 | 31610028 |
Muscle necrosis | 19.48 | 10.32 | 16 | 72385 | 847 | 31624096 |
Oedema peripheral | 19.43 | 10.32 | 159 | 72242 | 109680 | 31515263 |
Poisoning | 19.39 | 10.32 | 60 | 72341 | 10331 | 31614612 |
Septum pellucidum agenesis | 19.33 | 10.32 | 7 | 72394 | 66 | 31624877 |
Hypoglycaemia neonatal | 19.19 | 10.32 | 22 | 72379 | 1760 | 31623183 |
Retrograde amnesia | 18.95 | 10.32 | 8 | 72393 | 117 | 31624826 |
Atrial septal defect | 18.92 | 10.32 | 46 | 72355 | 6881 | 31618062 |
Plasma cell myeloma | 18.86 | 10.32 | 66 | 72335 | 56465 | 31568478 |
Brain stem haematoma | 18.77 | 10.32 | 8 | 72393 | 120 | 31624823 |
Inappropriate antidiuretic hormone secretion | 18.75 | 10.32 | 63 | 72338 | 11324 | 31613619 |
Bradyphrenia | 18.70 | 10.32 | 35 | 72366 | 4369 | 31620574 |
Contraindicated product administered | 18.63 | 10.32 | 11 | 72390 | 19761 | 31605182 |
Urticaria | 18.62 | 10.32 | 68 | 72333 | 57449 | 31567494 |
Condition aggravated | 18.50 | 10.32 | 498 | 71903 | 163511 | 31461432 |
Neutrophil count decreased | 18.44 | 10.32 | 50 | 72351 | 46344 | 31578599 |
Bradykinesia | 18.42 | 10.32 | 31 | 72370 | 3561 | 31621382 |
Physical deconditioning | 18.33 | 10.32 | 16 | 72385 | 921 | 31624022 |
Drug resistance | 18.25 | 10.32 | 16 | 72385 | 23437 | 31601506 |
Post-traumatic stress disorder | 18.24 | 10.32 | 21 | 72380 | 1688 | 31623255 |
Trisomy 21 | 18.22 | 10.32 | 13 | 72388 | 557 | 31624386 |
Toxic epidermal necrolysis | 18.21 | 10.32 | 11 | 72390 | 19513 | 31605430 |
Infection | 18.20 | 10.32 | 111 | 72290 | 81820 | 31543123 |
Physical assault | 17.99 | 10.32 | 17 | 72384 | 1085 | 31623858 |
Mental impairment | 17.75 | 10.32 | 55 | 72346 | 9477 | 31615466 |
Neonatal seizure | 17.72 | 10.32 | 12 | 72389 | 472 | 31624471 |
Congenital pulmonary hypertension | 17.65 | 10.32 | 6 | 72395 | 46 | 31624897 |
Pain in extremity | 17.59 | 10.32 | 175 | 72226 | 116028 | 31508915 |
Inflammation | 17.57 | 10.32 | 19 | 72382 | 25222 | 31599721 |
Reactive psychosis | 17.57 | 10.32 | 4 | 72397 | 4 | 31624939 |
Electrocardiogram QT shortened | 17.40 | 10.32 | 8 | 72393 | 145 | 31624798 |
Exposure during pregnancy | 17.32 | 10.32 | 51 | 72350 | 8547 | 31616396 |
Drug eruption | 17.31 | 10.32 | 10 | 72391 | 18177 | 31606766 |
Dysgraphia | 17.15 | 10.32 | 23 | 72378 | 2160 | 31622783 |
Pelvic kidney | 17.12 | 10.32 | 7 | 72394 | 94 | 31624849 |
Leukopenia | 17.04 | 10.32 | 71 | 72330 | 57757 | 31567186 |
Aspergillus infection | 16.82 | 10.32 | 3 | 72398 | 11525 | 31613418 |
Behaviour disorder | 16.57 | 10.32 | 33 | 72368 | 4314 | 31620629 |
Neuropathy peripheral | 16.54 | 10.32 | 103 | 72298 | 75546 | 31549397 |
Panic disorder | 16.51 | 10.32 | 17 | 72384 | 1205 | 31623738 |
Neutropenic sepsis | 16.46 | 10.32 | 4 | 72397 | 12375 | 31612568 |
Hyperglycaemia | 16.30 | 10.32 | 37 | 72364 | 36439 | 31588504 |
Feeling of despair | 16.28 | 10.32 | 15 | 72386 | 927 | 31624016 |
Hypertonia | 16.19 | 10.32 | 31 | 72370 | 3937 | 31621006 |
Medication error | 16.11 | 10.32 | 98 | 72303 | 22674 | 31602269 |
Postictal psychosis | 16.07 | 10.32 | 8 | 72393 | 174 | 31624769 |
Pneumocystis jirovecii pneumonia | 16.04 | 10.32 | 11 | 72390 | 18240 | 31606703 |
Dementia with Lewy bodies | 15.91 | 10.32 | 13 | 72388 | 683 | 31624260 |
Cough | 15.76 | 10.32 | 215 | 72186 | 134599 | 31490344 |
Personality disorder | 15.69 | 10.32 | 16 | 72385 | 1121 | 31623822 |
Depersonalisation/derealisation disorder | 15.66 | 10.32 | 12 | 72389 | 574 | 31624369 |
Nightmare | 15.63 | 10.32 | 62 | 72339 | 12075 | 31612868 |
Pancytopenia | 15.62 | 10.32 | 126 | 72275 | 87190 | 31537753 |
Congenital hydronephrosis | 15.54 | 10.32 | 13 | 72388 | 706 | 31624237 |
Helplessness | 15.51 | 10.32 | 6 | 72395 | 69 | 31624874 |
Dissociation | 15.51 | 10.32 | 17 | 72384 | 1295 | 31623648 |
Feelings of worthlessness | 15.50 | 10.32 | 9 | 72392 | 269 | 31624674 |
Palmar-plantar erythrodysaesthesia syndrome | 15.48 | 10.32 | 8 | 72393 | 15475 | 31609468 |
Arthralgia | 15.44 | 10.32 | 248 | 72153 | 151176 | 31473767 |
Atrial fibrillation | 15.34 | 10.32 | 176 | 72225 | 113607 | 31511336 |
Erythema | 15.33 | 10.32 | 114 | 72287 | 80291 | 31544652 |
Tumour lysis syndrome | 15.31 | 10.32 | 8 | 72393 | 15377 | 31609566 |
White blood cell count decreased | 15.23 | 10.32 | 127 | 72274 | 87271 | 31537672 |
Neonatal hyponatraemia | 15.21 | 10.32 | 6 | 72395 | 73 | 31624870 |
Family stress | 15.02 | 10.32 | 7 | 72394 | 131 | 31624812 |
Dementia | 15.01 | 10.32 | 62 | 72339 | 12298 | 31612645 |
Hypersensitivity | 14.88 | 10.32 | 71 | 72330 | 55672 | 31569271 |
Somatic symptom disorder | 14.82 | 10.32 | 12 | 72389 | 622 | 31624321 |
Sleep-related eating disorder | 14.78 | 10.32 | 9 | 72392 | 294 | 31624649 |
Ejaculation failure | 14.75 | 10.32 | 13 | 72388 | 758 | 31624185 |
Chemical submission | 14.75 | 10.32 | 5 | 72396 | 38 | 31624905 |
Renal dysplasia | 14.75 | 10.32 | 8 | 72393 | 209 | 31624734 |
Graft versus host disease | 14.64 | 10.32 | 3 | 72398 | 10444 | 31614499 |
Weight increased | 14.45 | 10.32 | 268 | 72133 | 82679 | 31542264 |
Gastrointestinal haemorrhage | 14.36 | 10.32 | 120 | 72281 | 82429 | 31542514 |
Personality change | 14.35 | 10.32 | 33 | 72368 | 4762 | 31620181 |
Alcohol abuse | 14.32 | 10.32 | 32 | 72369 | 4532 | 31620411 |
Joint swelling | 14.29 | 10.32 | 68 | 72333 | 53363 | 31571580 |
Swelling | 14.29 | 10.32 | 41 | 72360 | 37317 | 31587626 |
Dizziness | 14.26 | 10.32 | 573 | 71828 | 198574 | 31426369 |
Sperm concentration decreased | 14.24 | 10.32 | 7 | 72394 | 148 | 31624795 |
Thinking abnormal | 14.16 | 10.32 | 36 | 72365 | 5537 | 31619406 |
Muscle twitching | 13.97 | 10.32 | 46 | 72355 | 8184 | 31616759 |
Head discomfort | 13.79 | 10.32 | 28 | 72373 | 3711 | 31621232 |
Hepatotoxicity | 13.76 | 10.32 | 14 | 72387 | 19112 | 31605831 |
Sexually inappropriate behaviour | 13.60 | 10.32 | 10 | 72391 | 449 | 31624494 |
Illness anxiety disorder | 13.44 | 10.32 | 7 | 72394 | 168 | 31624775 |
Rabbit syndrome | 13.38 | 10.32 | 4 | 72397 | 19 | 31624924 |
Abnormal clotting factor | 13.37 | 10.32 | 5 | 72396 | 52 | 31624891 |
Nasopharyngitis | 13.37 | 10.32 | 87 | 72314 | 63158 | 31561785 |
Back pain | 13.32 | 10.32 | 173 | 72228 | 109240 | 31515703 |
Male orgasmic disorder | 13.29 | 10.32 | 6 | 72395 | 104 | 31624839 |
Renal haemorrhage | 13.24 | 10.32 | 16 | 72385 | 1354 | 31623589 |
Myocardial infarction | 13.23 | 10.32 | 181 | 72220 | 113273 | 31511670 |
Delusional disorder, erotomanic type | 13.18 | 10.32 | 3 | 72398 | 3 | 31624940 |
Rapid eye movements sleep abnormal | 13.07 | 10.32 | 7 | 72394 | 178 | 31624765 |
Loss of employment | 13.06 | 10.32 | 10 | 72391 | 478 | 31624465 |
Mucosal inflammation | 13.01 | 10.32 | 38 | 72363 | 34389 | 31590554 |
Ureteric haemorrhage | 12.99 | 10.32 | 6 | 72395 | 110 | 31624833 |
Pneumonitis | 12.97 | 10.32 | 32 | 72369 | 30620 | 31594323 |
Human herpesvirus 6 infection | 12.97 | 10.32 | 19 | 72382 | 1938 | 31623005 |
Social fear | 12.72 | 10.32 | 3 | 72398 | 4 | 31624939 |
Yawning | 12.70 | 10.32 | 10 | 72391 | 498 | 31624445 |
Stress | 12.69 | 10.32 | 99 | 72302 | 24842 | 31600101 |
Suicidal behaviour | 12.67 | 10.32 | 16 | 72385 | 1416 | 31623527 |
Hypokinesia | 12.65 | 10.32 | 44 | 72357 | 8048 | 31616895 |
Affective disorder | 12.64 | 10.32 | 27 | 72374 | 3709 | 31621234 |
Somnambulism | 12.53 | 10.32 | 23 | 72378 | 2829 | 31622114 |
Premature ejaculation | 12.47 | 10.32 | 6 | 72395 | 121 | 31624822 |
Feeling jittery | 12.43 | 10.32 | 27 | 72374 | 3750 | 31621193 |
Hepatic failure | 12.43 | 10.32 | 36 | 72365 | 32666 | 31592277 |
Haemoglobin decreased | 12.34 | 10.32 | 182 | 72219 | 112493 | 31512450 |
Hypospadias | 12.29 | 10.32 | 24 | 72377 | 3092 | 31621851 |
Chronic kidney disease | 12.22 | 10.32 | 45 | 72356 | 37930 | 31587013 |
Venous angioma of brain | 12.08 | 10.32 | 4 | 72397 | 28 | 31624915 |
Stress at work | 12.03 | 10.32 | 7 | 72394 | 210 | 31624733 |
Acute myeloid leukaemia | 11.98 | 10.32 | 15 | 72386 | 18657 | 31606286 |
Multiple drug therapy | 11.98 | 10.32 | 9 | 72392 | 418 | 31624525 |
Electrocardiogram abnormal | 11.97 | 10.32 | 43 | 72358 | 7993 | 31616950 |
Logorrhoea | 11.87 | 10.32 | 20 | 72381 | 2299 | 31622644 |
Selective eating disorder | 11.83 | 10.32 | 17 | 72384 | 1703 | 31623240 |
Liver disorder | 11.81 | 10.32 | 32 | 72369 | 29675 | 31595268 |
Prostate cancer | 11.81 | 10.32 | 45 | 72356 | 37556 | 31587387 |
Grandiosity | 11.78 | 10.32 | 8 | 72393 | 316 | 31624627 |
Tearfulness | 11.75 | 10.32 | 18 | 72383 | 1909 | 31623034 |
Acute myocardial infarction | 11.73 | 10.32 | 68 | 72333 | 50755 | 31574188 |
Haemophagocytic lymphohistiocytosis | 11.73 | 10.32 | 6 | 72395 | 11672 | 31613271 |
Carbon dioxide increased | 11.69 | 10.32 | 13 | 72388 | 1006 | 31623937 |
Pleural effusion | 11.67 | 10.32 | 112 | 72289 | 74808 | 31550135 |
Affect lability | 11.67 | 10.32 | 25 | 72376 | 3440 | 31621503 |
Generalised anxiety disorder | 11.62 | 10.32 | 11 | 72390 | 704 | 31624239 |
Frustration tolerance decreased | 11.56 | 10.32 | 20 | 72381 | 2348 | 31622595 |
Lung neoplasm malignant | 11.54 | 10.32 | 12 | 72389 | 16218 | 31608725 |
Prescription form tampering | 11.52 | 10.32 | 9 | 72392 | 443 | 31624500 |
Bladder cancer | 11.51 | 10.32 | 10 | 72391 | 14715 | 31610228 |
Treatment failure | 11.45 | 10.32 | 51 | 72350 | 40741 | 31584202 |
Obsessive-compulsive personality disorder | 11.41 | 10.32 | 6 | 72395 | 147 | 31624796 |
Congenital megaureter | 11.41 | 10.32 | 6 | 72395 | 147 | 31624796 |
Attention deficit hyperactivity disorder | 11.38 | 10.32 | 20 | 72381 | 2378 | 31622565 |
Autoscopy | 11.37 | 10.32 | 6 | 72395 | 148 | 31624795 |
Paresis | 11.34 | 10.32 | 18 | 72383 | 1969 | 31622974 |
C-reactive protein increased | 11.28 | 10.32 | 65 | 72336 | 48585 | 31576358 |
Fluid retention | 11.21 | 10.32 | 25 | 72376 | 24777 | 31600166 |
Generalised tonic-clonic seizure | 11.21 | 10.32 | 81 | 72320 | 19850 | 31605093 |
Colitis microscopic | 11.19 | 10.32 | 18 | 72383 | 1992 | 31622951 |
Suture rupture | 11.17 | 10.32 | 8 | 72393 | 345 | 31624598 |
Nephropathy toxic | 11.15 | 10.32 | 6 | 72395 | 11347 | 31613596 |
Hyperammonaemic encephalopathy | 11.13 | 10.32 | 19 | 72382 | 2207 | 31622736 |
Pulmonary fibrosis | 11.10 | 10.32 | 13 | 72388 | 16647 | 31608296 |
Sprue-like enteropathy | 11.08 | 10.32 | 9 | 72392 | 469 | 31624474 |
Normochromic normocytic anaemia | 11.06 | 10.32 | 26 | 72375 | 3806 | 31621137 |
Mood altered | 11.05 | 10.32 | 43 | 72358 | 8303 | 31616640 |
Impaired work ability | 11.02 | 10.32 | 34 | 72367 | 5843 | 31619100 |
Theft | 10.91 | 10.32 | 7 | 72394 | 251 | 31624692 |
Hypocalcaemia | 10.91 | 10.32 | 21 | 72380 | 21957 | 31602986 |
Herpes zoster | 10.90 | 10.32 | 37 | 72364 | 31956 | 31592987 |
Anaphylactic reaction | 10.89 | 10.32 | 33 | 72368 | 29520 | 31595423 |
Tinnitus | 10.86 | 10.32 | 69 | 72332 | 16206 | 31608737 |
Balance disorder | 10.85 | 10.32 | 132 | 72269 | 37290 | 31587653 |
Imprisonment | 10.83 | 10.32 | 9 | 72392 | 484 | 31624459 |
Exposure via breast milk | 10.82 | 10.32 | 17 | 72384 | 1843 | 31623100 |
Sleep disorder due to a general medical condition | 10.75 | 10.32 | 26 | 72375 | 3876 | 31621067 |
Telangiectasia | 10.74 | 10.32 | 11 | 72390 | 775 | 31624168 |
Neonatal tachypnoea | 10.72 | 10.32 | 6 | 72395 | 167 | 31624776 |
Posterior reversible encephalopathy syndrome | 10.69 | 10.32 | 4 | 72397 | 9363 | 31615580 |
Urinary incontinence | 10.68 | 10.32 | 72 | 72329 | 17248 | 31607695 |
Obsessive thoughts | 10.65 | 10.32 | 10 | 72391 | 633 | 31624310 |
Steroid dependence | 10.64 | 10.32 | 9 | 72392 | 496 | 31624447 |
Congenital diaphragmatic hernia | 10.60 | 10.32 | 7 | 72394 | 264 | 31624679 |
Anaphylactic shock | 10.59 | 10.32 | 10 | 72391 | 14135 | 31610808 |
Pulmonary oedema | 10.57 | 10.32 | 59 | 72342 | 44443 | 31580500 |
Flat affect | 10.54 | 10.32 | 11 | 72390 | 792 | 31624151 |
Tuberculosis | 10.51 | 10.32 | 3 | 72398 | 8338 | 31616605 |
Hyponatriuria | 10.45 | 10.32 | 3 | 72398 | 12 | 31624931 |
Feminisation acquired | 10.42 | 10.32 | 4 | 72397 | 45 | 31624898 |
Renal tubular necrosis | 10.40 | 10.32 | 11 | 72390 | 14748 | 31610195 |
Lens dislocation | 10.38 | 10.32 | 5 | 72396 | 101 | 31624842 |
Hypervolaemia | 10.37 | 10.32 | 16 | 72385 | 18235 | 31606708 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Serotonin syndrome | 635.51 | 9.63 | 658 | 182687 | 41456 | 70703643 |
Suicide attempt | 618.29 | 9.63 | 888 | 182457 | 78622 | 70666477 |
Suicidal ideation | 606.40 | 9.63 | 821 | 182524 | 68775 | 70676324 |
Intentional overdose | 566.54 | 9.63 | 957 | 182388 | 97478 | 70647621 |
Completed suicide | 554.15 | 9.63 | 1560 | 181785 | 225575 | 70519524 |
Anxiety | 517.71 | 9.63 | 1493 | 181852 | 218837 | 70526262 |
Depression | 508.35 | 9.63 | 1390 | 181955 | 197584 | 70547515 |
Electrocardiogram QT prolonged | 433.56 | 9.63 | 776 | 182569 | 82741 | 70662358 |
Sopor | 409.01 | 9.63 | 453 | 182892 | 30814 | 70714285 |
Somnolence | 329.77 | 9.63 | 1264 | 182081 | 214342 | 70530757 |
Overdose | 292.95 | 9.63 | 1035 | 182310 | 168710 | 70576389 |
Drug interaction | 260.99 | 9.63 | 1783 | 181562 | 379658 | 70365441 |
Agitation | 246.76 | 9.63 | 661 | 182684 | 92714 | 70652385 |
Tremor | 242.41 | 9.63 | 918 | 182427 | 154706 | 70590393 |
Rheumatoid arthritis | 235.63 | 9.63 | 244 | 183101 | 291561 | 70453538 |
Intentional self-injury | 234.94 | 9.63 | 346 | 182999 | 31304 | 70713795 |
Synovitis | 222.60 | 9.63 | 34 | 183311 | 129194 | 70615905 |
Pemphigus | 198.95 | 9.63 | 3 | 183342 | 83033 | 70662066 |
Coma | 194.98 | 9.63 | 601 | 182744 | 91243 | 70653856 |
Hand deformity | 182.60 | 9.63 | 10 | 183335 | 86472 | 70658627 |
Contraindicated product administered | 179.24 | 9.63 | 62 | 183283 | 134550 | 70610549 |
Withdrawal syndrome | 167.43 | 9.63 | 260 | 183085 | 24644 | 70720455 |
Joint swelling | 161.49 | 9.63 | 253 | 183092 | 252958 | 70492141 |
Arthropathy | 156.68 | 9.63 | 97 | 183248 | 149960 | 70595139 |
Infusion related reaction | 155.07 | 9.63 | 169 | 183176 | 197365 | 70547734 |
Product substitution issue | 151.47 | 9.63 | 212 | 183133 | 18301 | 70726798 |
Mania | 148.53 | 9.63 | 202 | 183143 | 16972 | 70728127 |
Poisoning deliberate | 148.06 | 9.63 | 201 | 183144 | 16859 | 70728240 |
Drug intolerance | 147.25 | 9.63 | 222 | 183123 | 225465 | 70519634 |
Systemic lupus erythematosus | 146.28 | 9.63 | 41 | 183304 | 101861 | 70643238 |
Treatment failure | 143.92 | 9.63 | 98 | 183247 | 144044 | 70601055 |
Aggression | 139.23 | 9.63 | 354 | 182991 | 48092 | 70697007 |
Fall | 137.23 | 9.63 | 1751 | 181594 | 442345 | 70302754 |
Hyponatraemia | 136.33 | 9.63 | 792 | 182553 | 159295 | 70585804 |
Inappropriate antidiuretic hormone secretion | 135.99 | 9.63 | 228 | 183117 | 23048 | 70722051 |
Febrile neutropenia | 132.29 | 9.63 | 202 | 183143 | 204116 | 70540983 |
Akathisia | 130.45 | 9.63 | 160 | 183185 | 12133 | 70732966 |
Irritability | 129.88 | 9.63 | 298 | 183047 | 37927 | 70707172 |
Paranoia | 123.99 | 9.63 | 186 | 183159 | 17102 | 70727997 |
Panic attack | 117.85 | 9.63 | 208 | 183137 | 21911 | 70723188 |
Duodenal ulcer perforation | 117.81 | 9.63 | 3 | 183342 | 51109 | 70693990 |
Glossodynia | 116.56 | 9.63 | 39 | 183306 | 86448 | 70658651 |
Muscle rigidity | 116.11 | 9.63 | 188 | 183157 | 18462 | 70726637 |
Helicobacter infection | 115.76 | 9.63 | 7 | 183338 | 55649 | 70689450 |
Swelling | 113.06 | 9.63 | 196 | 183149 | 188343 | 70556756 |
Torsade de pointes | 107.90 | 9.63 | 179 | 183166 | 17937 | 70727162 |
Mydriasis | 106.29 | 9.63 | 167 | 183178 | 15986 | 70729113 |
Seizure | 102.46 | 9.63 | 799 | 182546 | 177163 | 70567936 |
Disturbance in attention | 101.72 | 9.63 | 292 | 183053 | 42602 | 70702497 |
Mental disorder | 101.34 | 9.63 | 225 | 183120 | 28015 | 70717084 |
Pericarditis | 101.27 | 9.63 | 46 | 183299 | 84659 | 70660440 |
Tardive dyskinesia | 97.01 | 9.63 | 124 | 183221 | 9805 | 70735294 |
Wound | 96.06 | 9.63 | 69 | 183276 | 98663 | 70646436 |
Hyperhidrosis | 95.61 | 9.63 | 625 | 182720 | 130961 | 70614138 |
Insomnia | 90.27 | 9.63 | 910 | 182435 | 216896 | 70528203 |
Acute kidney injury | 90.09 | 9.63 | 789 | 182556 | 473835 | 70271264 |
Confusional state | 89.64 | 9.63 | 1126 | 182219 | 283272 | 70461827 |
Dyskinesia | 89.19 | 9.63 | 271 | 183074 | 40803 | 70704296 |
Loss of consciousness | 88.44 | 9.63 | 697 | 182648 | 155019 | 70590080 |
Restlessness | 86.88 | 9.63 | 273 | 183072 | 41855 | 70703244 |
Crying | 85.37 | 9.63 | 177 | 183168 | 21022 | 70724077 |
Apathy | 85.22 | 9.63 | 128 | 183217 | 11780 | 70733319 |
Neutropenia | 84.82 | 9.63 | 359 | 182986 | 256797 | 70488302 |
Sepsis | 84.66 | 9.63 | 335 | 183010 | 244210 | 70500889 |
Drug withdrawal syndrome | 83.75 | 9.63 | 229 | 183116 | 32486 | 70712613 |
Arthralgia | 81.50 | 9.63 | 870 | 182475 | 502520 | 70242579 |
Peripheral swelling | 81.30 | 9.63 | 325 | 183020 | 236238 | 70508861 |
Stomatitis | 81.28 | 9.63 | 129 | 183216 | 128382 | 70616717 |
Lower respiratory tract infection | 81.05 | 9.63 | 102 | 183243 | 111811 | 70633288 |
Depressed mood | 80.50 | 9.63 | 273 | 183072 | 43547 | 70701552 |
Electrocardiogram QRS complex prolonged | 79.78 | 9.63 | 112 | 183233 | 9694 | 70735405 |
Hyperreflexia | 79.19 | 9.63 | 97 | 183248 | 7345 | 70737754 |
Sexual dysfunction | 79.19 | 9.63 | 92 | 183253 | 6589 | 70738510 |
Anger | 78.68 | 9.63 | 146 | 183199 | 15986 | 70729113 |
Folliculitis | 78.54 | 9.63 | 9 | 183336 | 42561 | 70702538 |
Pyrexia | 77.87 | 9.63 | 1103 | 182242 | 605849 | 70139250 |
Rash | 77.66 | 9.63 | 895 | 182450 | 509667 | 70235432 |
Multiple organ dysfunction syndrome | 77.45 | 9.63 | 100 | 183245 | 108415 | 70636684 |
Infection | 77.32 | 9.63 | 282 | 183063 | 210503 | 70534596 |
Neuroleptic malignant syndrome | 76.76 | 9.63 | 192 | 183153 | 25815 | 70719284 |
Muscle injury | 76.68 | 9.63 | 6 | 183339 | 38488 | 70706611 |
Hallucination | 75.39 | 9.63 | 393 | 182952 | 75867 | 70669232 |
Major depression | 74.37 | 9.63 | 101 | 183244 | 8473 | 70736626 |
Reversible cerebral vasoconstriction syndrome | 74.22 | 9.63 | 59 | 183286 | 2626 | 70742473 |
Hypersensitivity | 72.62 | 9.63 | 326 | 183019 | 229486 | 70515613 |
Alopecia | 71.19 | 9.63 | 268 | 183077 | 198222 | 70546877 |
Long QT syndrome | 71.05 | 9.63 | 78 | 183267 | 5249 | 70739850 |
Intrusive thoughts | 70.87 | 9.63 | 30 | 183315 | 387 | 70744712 |
Hallucination, visual | 69.83 | 9.63 | 200 | 183145 | 29137 | 70715962 |
Sympathomimetic effect | 69.34 | 9.63 | 19 | 183326 | 52 | 70745047 |
Drug ineffective | 69.25 | 9.63 | 1876 | 181469 | 937876 | 69807223 |
Off label use | 69.21 | 9.63 | 1431 | 181914 | 741629 | 70003470 |
Renal impairment | 67.47 | 9.63 | 172 | 183173 | 143765 | 70601334 |
Clonus | 67.18 | 9.63 | 82 | 183263 | 6186 | 70738913 |
Psychotic disorder | 65.86 | 9.63 | 231 | 183114 | 37470 | 70707629 |
Hallucination, auditory | 65.72 | 9.63 | 146 | 183199 | 18182 | 70726917 |
Impaired healing | 64.80 | 9.63 | 58 | 183287 | 74316 | 70670783 |
C-reactive protein abnormal | 64.50 | 9.63 | 11 | 183334 | 38568 | 70706531 |
Inflammation | 64.26 | 9.63 | 65 | 183280 | 78600 | 70666499 |
Drug hypersensitivity | 62.65 | 9.63 | 409 | 182936 | 262050 | 70483049 |
Multiple sclerosis relapse | 62.18 | 9.63 | 248 | 183097 | 42769 | 70702330 |
Abnormal behaviour | 61.79 | 9.63 | 214 | 183131 | 34495 | 70710604 |
Interstitial lung disease | 61.66 | 9.63 | 110 | 183235 | 104575 | 70640524 |
Extrapyramidal disorder | 61.04 | 9.63 | 153 | 183192 | 20597 | 70724502 |
Activation syndrome | 60.92 | 9.63 | 24 | 183321 | 254 | 70744845 |
Septic shock | 60.83 | 9.63 | 124 | 183221 | 112134 | 70632965 |
Depressed level of consciousness | 60.30 | 9.63 | 410 | 182935 | 87021 | 70658078 |
Psychomotor hyperactivity | 59.98 | 9.63 | 127 | 183218 | 15306 | 70729793 |
Homicidal ideation | 59.47 | 9.63 | 57 | 183288 | 3266 | 70741833 |
Bruxism | 59.36 | 9.63 | 60 | 183285 | 3669 | 70741430 |
Hepatic enzyme increased | 58.90 | 9.63 | 208 | 183137 | 156782 | 70588317 |
Loss of libido | 58.82 | 9.63 | 50 | 183295 | 2447 | 70742652 |
Drug abuse | 57.99 | 9.63 | 609 | 182736 | 146647 | 70598452 |
Libido decreased | 57.10 | 9.63 | 67 | 183278 | 4849 | 70740250 |
Gun shot wound | 56.96 | 9.63 | 36 | 183309 | 1107 | 70743992 |
Myelosuppression | 56.55 | 9.63 | 6 | 183339 | 30139 | 70714960 |
Derealisation | 56.37 | 9.63 | 40 | 183305 | 1496 | 70743603 |
Therapeutic product effect decreased | 56.02 | 9.63 | 186 | 183159 | 142832 | 70602267 |
C-reactive protein increased | 55.79 | 9.63 | 127 | 183218 | 110390 | 70634709 |
Cardiac failure | 55.32 | 9.63 | 188 | 183157 | 143353 | 70601746 |
Cytomegalovirus infection | 55.20 | 9.63 | 17 | 183328 | 39741 | 70705358 |
Vital capacity decreased | 54.76 | 9.63 | 38 | 183307 | 1371 | 70743728 |
Reversible airways obstruction | 54.75 | 9.63 | 40 | 183305 | 1567 | 70743532 |
Blister | 54.50 | 9.63 | 111 | 183234 | 100415 | 70644684 |
Amnesia | 54.49 | 9.63 | 273 | 183072 | 51882 | 70693217 |
Tachyphrenia | 54.20 | 9.63 | 43 | 183302 | 1908 | 70743191 |
Hypertonia | 54.03 | 9.63 | 75 | 183270 | 6423 | 70738676 |
Feeling abnormal | 53.44 | 9.63 | 583 | 182762 | 141736 | 70603363 |
Anhedonia | 52.98 | 9.63 | 115 | 183230 | 14098 | 70731001 |
Toxicity to various agents | 52.81 | 9.63 | 1327 | 182018 | 380845 | 70364254 |
Platelet count decreased | 52.64 | 9.63 | 259 | 183086 | 177963 | 70567136 |
Discomfort | 52.55 | 9.63 | 122 | 183223 | 105314 | 70639785 |
Thrombocytopenia | 51.94 | 9.63 | 383 | 182962 | 238727 | 70506372 |
Pneumonia | 51.15 | 9.63 | 1163 | 182182 | 595069 | 70150030 |
Memory impairment | 51.10 | 9.63 | 412 | 182933 | 92229 | 70652870 |
Cholecystitis chronic | 51.02 | 9.63 | 89 | 183256 | 9287 | 70735812 |
Delusion | 50.90 | 9.63 | 136 | 183209 | 19029 | 70726070 |
Abdominal discomfort | 50.46 | 9.63 | 336 | 183009 | 214322 | 70530777 |
Pancytopenia | 50.37 | 9.63 | 210 | 183135 | 150897 | 70594202 |
Suicidal behaviour | 50.17 | 9.63 | 50 | 183295 | 3006 | 70742093 |
Libido increased | 49.39 | 9.63 | 40 | 183305 | 1829 | 70743270 |
Bipolar disorder | 49.15 | 9.63 | 78 | 183267 | 7530 | 70737569 |
Emotional distress | 48.71 | 9.63 | 208 | 183137 | 36980 | 70708119 |
Cerebral haematoma | 48.15 | 9.63 | 76 | 183269 | 7302 | 70737797 |
Bone marrow failure | 47.99 | 9.63 | 34 | 183311 | 48976 | 70696123 |
Galactorrhoea | 47.74 | 9.63 | 51 | 183294 | 3327 | 70741772 |
Dizziness | 45.82 | 9.63 | 1545 | 181800 | 462596 | 70282503 |
Alcoholism | 45.79 | 9.63 | 57 | 183288 | 4388 | 70740711 |
Spirometry abnormal | 45.21 | 9.63 | 26 | 183319 | 671 | 70744428 |
Muscle twitching | 45.10 | 9.63 | 133 | 183212 | 19694 | 70725405 |
Hypomania | 44.50 | 9.63 | 66 | 183279 | 6006 | 70739093 |
Abnormal dreams | 44.43 | 9.63 | 90 | 183255 | 10513 | 70734586 |
Mobility decreased | 43.82 | 9.63 | 129 | 183216 | 102870 | 70642229 |
Parkinsonism | 43.00 | 9.63 | 111 | 183234 | 15214 | 70729885 |
Psychomotor retardation | 42.69 | 9.63 | 62 | 183283 | 5536 | 70739563 |
Tonsillar ulcer | 41.87 | 9.63 | 21 | 183324 | 408 | 70744691 |
Hyperthermia | 40.99 | 9.63 | 115 | 183230 | 16556 | 70728543 |
Affective disorder | 40.70 | 9.63 | 71 | 183274 | 7408 | 70737691 |
Drug screen positive | 40.69 | 9.63 | 62 | 183283 | 5778 | 70739321 |
Hypersomnia | 40.48 | 9.63 | 132 | 183213 | 20632 | 70724467 |
Adjustment disorder with mixed anxiety and depressed mood | 39.97 | 9.63 | 13 | 183332 | 74 | 70745025 |
Pneumocystis jirovecii pneumonia | 39.77 | 9.63 | 14 | 183331 | 30068 | 70715031 |
Mucosal inflammation | 39.31 | 9.63 | 72 | 183273 | 67778 | 70677321 |
Disseminated intravascular coagulation | 38.99 | 9.63 | 19 | 183326 | 33579 | 70711520 |
Bronchial secretion retention | 38.30 | 9.63 | 43 | 183302 | 2967 | 70742132 |
Blood creatinine increased | 38.20 | 9.63 | 215 | 183130 | 142786 | 70602313 |
Abulia | 38.18 | 9.63 | 26 | 183319 | 909 | 70744190 |
Myoclonus | 38.13 | 9.63 | 152 | 183193 | 26203 | 70718896 |
Alcohol use | 37.87 | 9.63 | 53 | 183292 | 4574 | 70740525 |
Dyspnoea | 37.86 | 9.63 | 1617 | 181728 | 768443 | 69976656 |
Anaemia | 37.68 | 9.63 | 776 | 182569 | 402647 | 70342452 |
Screaming | 37.68 | 9.63 | 47 | 183298 | 3625 | 70741474 |
Depressive symptom | 37.51 | 9.63 | 56 | 183289 | 5125 | 70739974 |
Death | 37.43 | 9.63 | 1018 | 182327 | 509043 | 70236056 |
Arthritis | 37.28 | 9.63 | 129 | 183216 | 97851 | 70647248 |
Disorientation | 37.21 | 9.63 | 267 | 183078 | 57656 | 70687443 |
Irritable bowel syndrome | 37.17 | 9.63 | 46 | 183299 | 50804 | 70694295 |
Osteoporosis | 37.07 | 9.63 | 43 | 183302 | 48864 | 70696235 |
Malignant neoplasm progression | 37.05 | 9.63 | 175 | 183170 | 121564 | 70623535 |
Sedation | 37.03 | 9.63 | 227 | 183118 | 46504 | 70698595 |
Bradypnoea | 36.69 | 9.63 | 57 | 183288 | 5402 | 70739697 |
Catatonia | 36.44 | 9.63 | 71 | 183274 | 8062 | 70737037 |
Impulsive behaviour | 36.17 | 9.63 | 40 | 183305 | 2714 | 70742385 |
Social avoidant behaviour | 36.14 | 9.63 | 52 | 183293 | 4604 | 70740495 |
Sleep disorder | 35.99 | 9.63 | 306 | 183039 | 69566 | 70675533 |
Generalised tonic-clonic seizure | 35.98 | 9.63 | 207 | 183138 | 41454 | 70703645 |
Neutropenic sepsis | 35.60 | 9.63 | 10 | 183335 | 24820 | 70720279 |
Bradyphrenia | 35.40 | 9.63 | 79 | 183266 | 9867 | 70735232 |
Hepatic function abnormal | 35.24 | 9.63 | 77 | 183268 | 67919 | 70677180 |
Product use issue | 34.98 | 9.63 | 297 | 183048 | 179640 | 70565459 |
Nightmare | 34.68 | 9.63 | 131 | 183214 | 22025 | 70723074 |
Nasopharyngitis | 34.27 | 9.63 | 388 | 182957 | 221818 | 70523281 |
Self esteem decreased | 33.56 | 9.63 | 24 | 183321 | 909 | 70744190 |
Device dislocation | 33.52 | 9.63 | 131 | 183214 | 22376 | 70722723 |
Red blood cell sedimentation rate abnormal | 33.40 | 9.63 | 5 | 183340 | 19298 | 70725801 |
Obsessive-compulsive disorder | 33.24 | 9.63 | 54 | 183291 | 5316 | 70739783 |
Sinus bradycardia | 33.18 | 9.63 | 135 | 183210 | 23488 | 70721611 |
Persecutory delusion | 32.96 | 9.63 | 49 | 183296 | 4468 | 70740631 |
Optic nerve injury | 32.91 | 9.63 | 20 | 183325 | 573 | 70744526 |
Pregnancy | 32.69 | 9.63 | 135 | 183210 | 23646 | 70721453 |
Anorgasmia | 32.50 | 9.63 | 25 | 183320 | 1060 | 70744039 |
Aspergillus infection | 32.41 | 9.63 | 4 | 183341 | 17864 | 70727235 |
Emotional disorder | 32.28 | 9.63 | 91 | 183254 | 13135 | 70731964 |
Mood swings | 31.90 | 9.63 | 112 | 183233 | 18174 | 70726925 |
Hostility | 31.79 | 9.63 | 34 | 183311 | 2221 | 70742878 |
Negative thoughts | 31.73 | 9.63 | 27 | 183318 | 1323 | 70743776 |
Myocardial infarction | 31.73 | 9.63 | 287 | 183058 | 171358 | 70573741 |
Sinusitis | 31.67 | 9.63 | 282 | 183063 | 168913 | 70576186 |
Maternal exposure during pregnancy | 31.03 | 9.63 | 173 | 183172 | 115172 | 70629927 |
Orgasm abnormal | 30.90 | 9.63 | 13 | 183332 | 165 | 70744934 |
Knee arthroplasty | 30.78 | 9.63 | 26 | 183319 | 34275 | 70710824 |
Poor quality sleep | 30.76 | 9.63 | 119 | 183226 | 20230 | 70724869 |
Drug resistance | 30.68 | 9.63 | 32 | 183313 | 38158 | 70706941 |
Mite allergy | 30.58 | 9.63 | 22 | 183323 | 841 | 70744258 |
Cogwheel rigidity | 30.48 | 9.63 | 38 | 183307 | 2930 | 70742169 |
Neutrophil count decreased | 30.46 | 9.63 | 112 | 183233 | 83444 | 70661655 |
Resting tremor | 30.45 | 9.63 | 27 | 183318 | 1399 | 70743700 |
Head injury | 30.38 | 9.63 | 171 | 183174 | 33970 | 70711129 |
Pain in extremity | 30.34 | 9.63 | 632 | 182713 | 327450 | 70417649 |
Pain | 30.32 | 9.63 | 1323 | 182022 | 627493 | 70117606 |
Oculogyric crisis | 30.06 | 9.63 | 36 | 183309 | 2662 | 70742437 |
Behaviour disorder | 29.90 | 9.63 | 52 | 183293 | 5412 | 70739687 |
Sputum culture positive | 29.83 | 9.63 | 40 | 183305 | 3314 | 70741785 |
Bronchopulmonary aspergillosis | 29.12 | 9.63 | 9 | 183336 | 20993 | 70724106 |
Acute myocardial infarction | 29.07 | 9.63 | 94 | 183251 | 72793 | 70672306 |
Erectile dysfunction | 28.98 | 9.63 | 89 | 183256 | 13473 | 70731626 |
Dystonia | 28.79 | 9.63 | 114 | 183231 | 19592 | 70725507 |
Somnambulism | 28.71 | 9.63 | 50 | 183295 | 5210 | 70739889 |
Pulmonary embolism | 28.68 | 9.63 | 564 | 182781 | 155303 | 70589796 |
Alcohol abuse | 28.47 | 9.63 | 49 | 183296 | 5058 | 70740041 |
Pruritus | 28.44 | 9.63 | 678 | 182667 | 344882 | 70400217 |
Syncope | 28.30 | 9.63 | 593 | 182752 | 165116 | 70579983 |
Hip arthroplasty | 28.05 | 9.63 | 19 | 183326 | 28021 | 70717078 |
Restless legs syndrome | 28.05 | 9.63 | 108 | 183237 | 18320 | 70726779 |
Skin ulcer | 27.97 | 9.63 | 51 | 183294 | 48094 | 70697005 |
Lower respiratory tract infection viral | 27.89 | 9.63 | 23 | 183322 | 1079 | 70744020 |
Legal problem | 27.86 | 9.63 | 12 | 183333 | 162 | 70744937 |
Gestational diabetes | 27.64 | 9.63 | 53 | 183292 | 5948 | 70739151 |
Multiple sclerosis | 27.58 | 9.63 | 134 | 183211 | 25151 | 70719948 |
Plasma cell myeloma | 27.43 | 9.63 | 97 | 183248 | 73104 | 70671995 |
Miosis | 26.91 | 9.63 | 89 | 183256 | 14012 | 70731087 |
Musculoskeletal stiffness | 26.90 | 9.63 | 248 | 183097 | 147512 | 70597587 |
Disease progression | 26.81 | 9.63 | 267 | 183078 | 156405 | 70588694 |
Feeling jittery | 26.80 | 9.63 | 78 | 183267 | 11465 | 70733634 |
Renal failure | 26.52 | 9.63 | 337 | 183008 | 188733 | 70556366 |
Morose | 26.51 | 9.63 | 8 | 183337 | 34 | 70745065 |
Feeling guilty | 26.14 | 9.63 | 20 | 183325 | 841 | 70744258 |
Disinhibition | 26.13 | 9.63 | 31 | 183314 | 2270 | 70742829 |
Platelet aggregation inhibition | 26.12 | 9.63 | 11 | 183334 | 140 | 70744959 |
Bone erosion | 26.09 | 9.63 | 4 | 183341 | 15169 | 70729930 |
Rheumatoid nodule | 25.85 | 9.63 | 4 | 183341 | 15063 | 70730036 |
Bundle branch block left | 25.83 | 9.63 | 72 | 183273 | 10327 | 70734772 |
Fibromyalgia | 25.82 | 9.63 | 53 | 183292 | 47821 | 70697278 |
Sinus tachycardia | 25.78 | 9.63 | 163 | 183182 | 33750 | 70711349 |
Mental status changes | 25.78 | 9.63 | 263 | 183082 | 62838 | 70682261 |
Feeling of despair | 25.73 | 9.63 | 33 | 183312 | 2618 | 70742481 |
Thermohypoaesthesia | 25.71 | 9.63 | 10 | 183335 | 102 | 70744997 |
Respiratory arrest | 25.59 | 9.63 | 232 | 183113 | 53701 | 70691398 |
Poisoning | 25.47 | 9.63 | 121 | 183224 | 22501 | 70722598 |
Tachycardia | 25.35 | 9.63 | 562 | 182783 | 157984 | 70587115 |
Orthostatic hypotension | 25.28 | 9.63 | 224 | 183121 | 51519 | 70693580 |
Nervousness | 25.18 | 9.63 | 152 | 183193 | 30968 | 70714131 |
Sepsis neonatal | 25.13 | 9.63 | 8 | 183337 | 42 | 70745057 |
Bradycardia | 25.01 | 9.63 | 457 | 182888 | 124158 | 70620941 |
Stiff person syndrome | 25.00 | 9.63 | 14 | 183331 | 343 | 70744756 |
Delirium | 24.99 | 9.63 | 299 | 183046 | 74315 | 70670784 |
Sight disability | 24.88 | 9.63 | 10 | 183335 | 112 | 70744987 |
Conjunctivitis allergic | 24.71 | 9.63 | 22 | 183323 | 1146 | 70743953 |
Initial insomnia | 24.61 | 9.63 | 52 | 183293 | 6257 | 70738842 |
Moaning | 24.53 | 9.63 | 21 | 183324 | 1038 | 70744061 |
Angle closure glaucoma | 24.50 | 9.63 | 33 | 183312 | 2746 | 70742353 |
Pyramidal tract syndrome | 24.15 | 9.63 | 16 | 183329 | 534 | 70744565 |
Learning disorder | 24.02 | 9.63 | 16 | 183329 | 539 | 70744560 |
Conversion disorder | 24.02 | 9.63 | 26 | 183319 | 1722 | 70743377 |
Mycotic allergy | 23.77 | 9.63 | 21 | 183324 | 1083 | 70744016 |
Judgement impaired | 23.77 | 9.63 | 21 | 183324 | 1083 | 70744016 |
Ill-defined disorder | 23.69 | 9.63 | 68 | 183277 | 54673 | 70690426 |
Muscle necrosis | 23.60 | 9.63 | 23 | 183322 | 1345 | 70743754 |
Dysphoria | 23.57 | 9.63 | 42 | 183303 | 4456 | 70740643 |
Lip ulceration | 23.50 | 9.63 | 28 | 183317 | 2060 | 70743039 |
Tumour lysis syndrome | 23.42 | 9.63 | 13 | 183332 | 21347 | 70723752 |
Postictal state | 23.38 | 9.63 | 25 | 183320 | 1633 | 70743466 |
Red blood cell sedimentation rate increased | 23.29 | 9.63 | 40 | 183305 | 38602 | 70706497 |
White blood cell count decreased | 23.22 | 9.63 | 305 | 183040 | 169836 | 70575263 |
Dysgraphia | 23.13 | 9.63 | 37 | 183308 | 3595 | 70741504 |
Transplant rejection | 23.10 | 9.63 | 9 | 183336 | 18162 | 70726937 |
Electrocardiogram QT interval | 23.00 | 9.63 | 11 | 183334 | 192 | 70744907 |
Haemophagocytic lymphohistiocytosis | 22.89 | 9.63 | 11 | 183334 | 19601 | 70725498 |
Hypertension | 22.67 | 9.63 | 587 | 182758 | 295446 | 70449653 |
Yawning | 22.60 | 9.63 | 22 | 183323 | 1285 | 70743814 |
Dust allergy | 22.51 | 9.63 | 21 | 183324 | 1163 | 70743936 |
Uterine perforation | 22.34 | 9.63 | 48 | 183297 | 5843 | 70739256 |
Mental impairment | 22.20 | 9.63 | 96 | 183249 | 17159 | 70727940 |
Ejaculation failure | 22.14 | 9.63 | 13 | 183332 | 349 | 70744750 |
Headache | 22.12 | 9.63 | 1764 | 181581 | 578641 | 70166458 |
Thinking abnormal | 22.05 | 9.63 | 75 | 183270 | 11976 | 70733123 |
Treatment noncompliance | 21.92 | 9.63 | 200 | 183145 | 46374 | 70698725 |
Fear | 21.78 | 9.63 | 109 | 183236 | 20702 | 70724397 |
Bradykinesia | 21.73 | 9.63 | 55 | 183290 | 7447 | 70737652 |
Nausea | 21.72 | 9.63 | 2517 | 180828 | 849571 | 69895528 |
Acute myeloid leukaemia | 21.57 | 9.63 | 29 | 183316 | 30911 | 70714188 |
Post-traumatic neck syndrome | 21.45 | 9.63 | 26 | 183319 | 1947 | 70743152 |
Victim of sexual abuse | 21.36 | 9.63 | 14 | 183331 | 459 | 70744640 |
Self-injurious ideation | 21.25 | 9.63 | 34 | 183311 | 3304 | 70741795 |
Ascites | 21.20 | 9.63 | 96 | 183249 | 67451 | 70677648 |
Haemoglobin decreased | 21.14 | 9.63 | 388 | 182957 | 204771 | 70540328 |
Atrial fibrillation | 21.13 | 9.63 | 342 | 183003 | 184006 | 70561093 |
Middle insomnia | 21.10 | 9.63 | 82 | 183263 | 13971 | 70731128 |
Cardiac failure congestive | 21.08 | 9.63 | 236 | 183109 | 135221 | 70609878 |
Antiphospholipid antibodies | 21.06 | 9.63 | 9 | 183336 | 119 | 70744980 |
Logorrhoea | 21.03 | 9.63 | 38 | 183307 | 4076 | 70741023 |
Neuropathy peripheral | 20.98 | 9.63 | 218 | 183127 | 126678 | 70618421 |
Blood prolactin increased | 20.90 | 9.63 | 36 | 183309 | 3718 | 70741381 |
Heavy menstrual bleeding | 20.75 | 9.63 | 76 | 183269 | 12589 | 70732510 |
Foot deformity | 20.66 | 9.63 | 14 | 183331 | 20641 | 70724458 |
Psychiatric symptom | 20.61 | 9.63 | 50 | 183295 | 6594 | 70738505 |
Epilepsy | 20.57 | 9.63 | 171 | 183174 | 38613 | 70706486 |
Sleep-related eating disorder | 20.50 | 9.63 | 16 | 183329 | 693 | 70744406 |
Band sensation | 20.44 | 9.63 | 16 | 183329 | 696 | 70744403 |
Bipolar I disorder | 20.42 | 9.63 | 25 | 183320 | 1892 | 70743207 |
Tension | 20.36 | 9.63 | 37 | 183308 | 3987 | 70741112 |
Tearfulness | 20.31 | 9.63 | 42 | 183303 | 4978 | 70740121 |
Weight increased | 20.25 | 9.63 | 792 | 182553 | 241539 | 70503560 |
Hyperglycaemia | 20.24 | 9.63 | 92 | 183253 | 64580 | 70680519 |
Gambling disorder | 20.20 | 9.63 | 25 | 183320 | 1913 | 70743186 |
Device expulsion | 20.18 | 9.63 | 112 | 183233 | 22134 | 70722965 |
Anaphylactic shock | 20.17 | 9.63 | 33 | 183312 | 32457 | 70712642 |
Male orgasmic disorder | 20.06 | 9.63 | 7 | 183338 | 51 | 70745048 |
Upper-airway cough syndrome | 20.00 | 9.63 | 63 | 183282 | 9668 | 70735431 |
Graft versus host disease | 19.84 | 9.63 | 7 | 183338 | 15016 | 70730083 |
Suspected suicide | 19.84 | 9.63 | 59 | 183286 | 8775 | 70736324 |
Migraine | 19.79 | 9.63 | 279 | 183066 | 71959 | 70673140 |
Euphoric mood | 19.43 | 9.63 | 50 | 183295 | 6839 | 70738260 |
Reduced facial expression | 19.34 | 9.63 | 27 | 183318 | 2325 | 70742774 |
Slow speech | 19.28 | 9.63 | 26 | 183319 | 2166 | 70742933 |
Psoriatic arthropathy | 19.18 | 9.63 | 94 | 183251 | 64677 | 70680422 |
Torticollis | 19.12 | 9.63 | 26 | 183319 | 2183 | 70742916 |
Family stress | 19.08 | 9.63 | 15 | 183330 | 657 | 70744442 |
Hypervigilance | 19.05 | 9.63 | 13 | 183332 | 456 | 70744643 |
Immobilisation prolonged | 18.98 | 9.63 | 8 | 183337 | 102 | 70744997 |
Biliary dyskinesia | 18.92 | 9.63 | 27 | 183318 | 2372 | 70742727 |
Erythema | 18.85 | 9.63 | 383 | 182962 | 199180 | 70545919 |
Deep vein thrombosis | 18.83 | 9.63 | 397 | 182948 | 110645 | 70634454 |
Intentional product use issue | 18.82 | 9.63 | 209 | 183136 | 119933 | 70625166 |
Chest injury | 18.75 | 9.63 | 28 | 183317 | 2563 | 70742536 |
Tubulointerstitial nephritis | 18.37 | 9.63 | 36 | 183309 | 33040 | 70712059 |
Dissociative disorder | 18.35 | 9.63 | 13 | 183332 | 485 | 70744614 |
Retroplacental haematoma | 18.18 | 9.63 | 8 | 183337 | 114 | 70744985 |
Painful respiration | 18.17 | 9.63 | 31 | 183314 | 3177 | 70741922 |
Illness anxiety disorder | 18.11 | 9.63 | 10 | 183335 | 238 | 70744861 |
Prostate cancer | 18.11 | 9.63 | 33 | 183312 | 31130 | 70713969 |
Foetal exposure during pregnancy | 18.07 | 9.63 | 43 | 183302 | 5602 | 70739497 |
Nephropathy toxic | 17.92 | 9.63 | 13 | 183332 | 18501 | 70726598 |
Tongue biting | 17.92 | 9.63 | 23 | 183322 | 1826 | 70743273 |
Intermenstrual bleeding | 17.90 | 9.63 | 41 | 183304 | 5209 | 70739890 |
Carcinoid syndrome | 17.80 | 9.63 | 9 | 183336 | 178 | 70744921 |
Self-medication | 17.77 | 9.63 | 37 | 183308 | 4406 | 70740693 |
Parkinsonian gait | 17.74 | 9.63 | 16 | 183329 | 848 | 70744251 |
Gynaecomastia | 17.70 | 9.63 | 48 | 183297 | 6775 | 70738324 |
Obsessive-compulsive personality disorder | 17.70 | 9.63 | 8 | 183337 | 122 | 70744977 |
Bundle branch block right | 17.66 | 9.63 | 64 | 183281 | 10546 | 70734553 |
Panic reaction | 17.59 | 9.63 | 36 | 183309 | 4235 | 70740864 |
Head banging | 17.56 | 9.63 | 13 | 183332 | 520 | 70744579 |
Enterocolitis | 17.41 | 9.63 | 6 | 183339 | 13060 | 70732039 |
Concussion | 17.41 | 9.63 | 55 | 183290 | 8454 | 70736645 |
Breast swelling | 17.38 | 9.63 | 18 | 183327 | 1133 | 70743966 |
Hepatotoxicity | 17.35 | 9.63 | 57 | 183288 | 43929 | 70701170 |
Barotrauma | 17.32 | 9.63 | 9 | 183336 | 189 | 70744910 |
Gallbladder disorder | 17.30 | 9.63 | 91 | 183254 | 17621 | 70727478 |
Cellulitis | 17.16 | 9.63 | 168 | 183177 | 98760 | 70646339 |
Compulsions | 17.10 | 9.63 | 11 | 183334 | 349 | 70744750 |
Obsessive thoughts | 17.00 | 9.63 | 17 | 183328 | 1026 | 70744073 |
Haemoglobin urine | 16.97 | 9.63 | 8 | 183337 | 135 | 70744964 |
Drug withdrawal syndrome neonatal | 16.92 | 9.63 | 10 | 183335 | 272 | 70744827 |
Lethargy | 16.90 | 9.63 | 281 | 183064 | 74969 | 70670130 |
Angina pectoris | 16.89 | 9.63 | 66 | 183279 | 48317 | 70696782 |
Pulmonary fibrosis | 16.85 | 9.63 | 40 | 183305 | 34270 | 70710829 |
Creatinine renal clearance decreased | 16.75 | 9.63 | 12 | 183333 | 17188 | 70727911 |
Palmar-plantar erythrodysaesthesia syndrome | 16.73 | 9.63 | 33 | 183312 | 30214 | 70714885 |
Speech disorder | 16.63 | 9.63 | 202 | 183143 | 50378 | 70694721 |
Decreased interest | 16.60 | 9.63 | 31 | 183314 | 3410 | 70741689 |
Grandiosity | 16.58 | 9.63 | 13 | 183332 | 567 | 70744532 |
Respiratory failure | 16.48 | 9.63 | 322 | 183023 | 168413 | 70576686 |
Trunk injury | 16.43 | 9.63 | 5 | 183340 | 22 | 70745077 |
Skin dystrophy | 16.39 | 9.63 | 6 | 183339 | 51 | 70745048 |
Kidney transplant rejection | 16.30 | 9.63 | 3 | 183342 | 9958 | 70735141 |
Pulmonary toxicity | 16.14 | 9.63 | 4 | 183341 | 10794 | 70734305 |
Urinary retention | 16.09 | 9.63 | 207 | 183138 | 52313 | 70692786 |
Large intestine anastomosis | 16.09 | 9.63 | 7 | 183338 | 97 | 70745002 |
Epstein-Barr virus infection | 16.03 | 9.63 | 7 | 183338 | 13191 | 70731908 |
Soft tissue injury | 16.03 | 9.63 | 21 | 183324 | 1701 | 70743398 |
Vertigo | 15.99 | 9.63 | 239 | 183106 | 62404 | 70682695 |
Osteoarthritis | 15.96 | 9.63 | 119 | 183226 | 74028 | 70671071 |
Partner stress | 15.81 | 9.63 | 10 | 183335 | 308 | 70744791 |
Multiple allergies | 15.73 | 9.63 | 50 | 183295 | 7710 | 70737389 |
Cerebral thrombosis | 15.63 | 9.63 | 24 | 183321 | 2252 | 70742847 |
General physical health deterioration | 15.52 | 9.63 | 478 | 182867 | 235553 | 70509546 |
Cardio-respiratory arrest | 15.50 | 9.63 | 355 | 182990 | 100322 | 70644777 |
Neoplasm malignant | 15.39 | 9.63 | 32 | 183313 | 28742 | 70716357 |
Personality disorder | 15.37 | 9.63 | 40 | 183305 | 5508 | 70739591 |
Freezing phenomenon | 15.33 | 9.63 | 20 | 183325 | 1614 | 70743485 |
Drug screen false positive | 15.32 | 9.63 | 16 | 183329 | 1017 | 70744082 |
Hypokinesia | 15.30 | 9.63 | 87 | 183258 | 17345 | 70727754 |
Coma scale abnormal | 15.29 | 9.63 | 51 | 183294 | 8065 | 70737034 |
Leukopenia | 15.28 | 9.63 | 189 | 183156 | 106371 | 70638728 |
Psychomotor skills impaired | 15.22 | 9.63 | 34 | 183311 | 4250 | 70740849 |
Sleep talking | 15.22 | 9.63 | 16 | 183329 | 1025 | 70744074 |
Pneumonitis | 15.17 | 9.63 | 81 | 183264 | 54516 | 70690583 |
Rectal ulcer | 15.15 | 9.63 | 22 | 183323 | 1964 | 70743135 |
Left ventricle outflow tract obstruction | 15.14 | 9.63 | 10 | 183335 | 332 | 70744767 |
Hypophosphataemia | 15.11 | 9.63 | 12 | 183333 | 16314 | 70728785 |
Retrograde amnesia | 15.06 | 9.63 | 12 | 183333 | 536 | 70744563 |
Hemianopia | 15.03 | 9.63 | 20 | 183325 | 1645 | 70743454 |
Imprisonment | 15.00 | 9.63 | 12 | 183333 | 539 | 70744560 |
Neoplasm progression | 14.97 | 9.63 | 63 | 183282 | 45165 | 70699934 |
Brain stem haematoma | 14.96 | 9.63 | 7 | 183338 | 116 | 70744983 |
Cough | 14.93 | 9.63 | 688 | 182657 | 324689 | 70420410 |
Tinnitus | 14.88 | 9.63 | 151 | 183194 | 36025 | 70709074 |
Reactive psychosis | 14.86 | 9.63 | 4 | 183341 | 10 | 70745089 |
Myositis | 14.80 | 9.63 | 14 | 183331 | 17475 | 70727624 |
Cerebellar syndrome | 14.79 | 9.63 | 38 | 183307 | 5193 | 70739906 |
Aphasia | 14.78 | 9.63 | 174 | 183171 | 43075 | 70702024 |
Anterograde amnesia | 14.74 | 9.63 | 13 | 183332 | 669 | 70744430 |
Pleural effusion | 14.72 | 9.63 | 248 | 183097 | 132616 | 70612483 |
Diffuse large B-cell lymphoma | 14.72 | 9.63 | 8 | 183337 | 13294 | 70731805 |
Ocular hypertension | 14.62 | 9.63 | 18 | 183327 | 1370 | 70743729 |
Inappropriate affect | 14.56 | 9.63 | 18 | 183327 | 1376 | 70743723 |
Spinal cord oedema | 14.50 | 9.63 | 10 | 183335 | 357 | 70744742 |
Caesarean section | 14.49 | 9.63 | 64 | 183281 | 11543 | 70733556 |
Basal cell carcinoma | 14.48 | 9.63 | 42 | 183303 | 33656 | 70711443 |
Road traffic accident | 14.38 | 9.63 | 145 | 183200 | 34537 | 70710562 |
Hepatitis infectious mononucleosis | 14.34 | 9.63 | 7 | 183338 | 128 | 70744971 |
Focal dyscognitive seizures | 14.31 | 9.63 | 29 | 183316 | 3388 | 70741711 |
Postural orthostatic tachycardia syndrome | 14.30 | 9.63 | 12 | 183333 | 577 | 70744522 |
Pneumonia fungal | 14.28 | 9.63 | 4 | 183341 | 9949 | 70735150 |
Musculoskeletal pain | 14.19 | 9.63 | 157 | 183188 | 90170 | 70654929 |
Lupus-like syndrome | 14.16 | 9.63 | 6 | 183339 | 11509 | 70733590 |
Device placement issue | 14.11 | 9.63 | 14 | 183331 | 837 | 70744262 |
Dysarthria | 14.11 | 9.63 | 233 | 183112 | 62080 | 70683019 |
Electrocardiogram abnormal | 14.09 | 9.63 | 75 | 183270 | 14589 | 70730510 |
Wheezing | 13.89 | 9.63 | 166 | 183179 | 94004 | 70651095 |
Extradural haematoma | 13.85 | 9.63 | 25 | 183320 | 2680 | 70742419 |
Autonomic nervous system imbalance | 13.83 | 9.63 | 33 | 183312 | 4306 | 70740793 |
Apnoea | 13.80 | 9.63 | 60 | 183285 | 10749 | 70734350 |
Neurotoxicity | 13.69 | 9.63 | 36 | 183309 | 29790 | 70715309 |
Electrocardiogram QT interval abnormal | 13.68 | 9.63 | 9 | 183336 | 297 | 70744802 |
Cyclic vomiting syndrome | 13.67 | 9.63 | 6 | 183339 | 85 | 70745014 |
Osteonecrosis of jaw | 13.64 | 9.63 | 57 | 183288 | 40945 | 70704154 |
Hyperphagia | 13.63 | 9.63 | 23 | 183322 | 2336 | 70742763 |
Flight of ideas | 13.59 | 9.63 | 13 | 183332 | 743 | 70744356 |
Drug-induced liver injury | 13.59 | 9.63 | 87 | 183258 | 56026 | 70689073 |
Belligerence | 13.57 | 9.63 | 9 | 183336 | 301 | 70744798 |
Ventricular dyskinesia | 13.55 | 9.63 | 10 | 183335 | 398 | 70744701 |
Intraventricular haemorrhage | 13.52 | 9.63 | 33 | 183312 | 4368 | 70740731 |
Product substitution error | 13.51 | 9.63 | 5 | 183340 | 44 | 70745055 |
Impaired driving ability | 13.44 | 9.63 | 35 | 183310 | 4822 | 70740277 |
Sebaceous gland infection | 13.43 | 9.63 | 7 | 183338 | 148 | 70744951 |
Inhibitory drug interaction | 13.28 | 9.63 | 30 | 183315 | 3777 | 70741322 |
Bladder cancer | 13.24 | 9.63 | 15 | 183330 | 17227 | 70727872 |
Atrial flutter | 13.23 | 9.63 | 20 | 183325 | 20307 | 70724792 |
Unresponsive to stimuli | 13.20 | 9.63 | 198 | 183147 | 51733 | 70693366 |
Device related infection | 13.19 | 9.63 | 41 | 183304 | 32144 | 70712955 |
Bursitis | 13.17 | 9.63 | 31 | 183314 | 26642 | 70718457 |
Liver disorder | 13.16 | 9.63 | 99 | 183246 | 61469 | 70683630 |
Compulsive shopping | 13.13 | 9.63 | 13 | 183332 | 775 | 70744324 |
Abortion spontaneous | 13.12 | 9.63 | 115 | 183230 | 26364 | 70718735 |
Ovarian vein thrombosis | 13.12 | 9.63 | 5 | 183340 | 48 | 70745051 |
Colitis microscopic | 13.08 | 9.63 | 52 | 183293 | 8953 | 70736146 |
Mood altered | 13.03 | 9.63 | 80 | 183265 | 16395 | 70728704 |
Balance disorder | 13.01 | 9.63 | 315 | 183030 | 89813 | 70655286 |
Oesophageal carcinoma | 13.01 | 9.63 | 4 | 183341 | 9362 | 70735737 |
Neuromyelitis optica spectrum disorder | 12.90 | 9.63 | 15 | 183330 | 1075 | 70744024 |
Victim of crime | 12.88 | 9.63 | 10 | 183335 | 430 | 70744669 |
Haematoma | 12.86 | 9.63 | 186 | 183159 | 48232 | 70696867 |
Hypermetropia | 12.86 | 9.63 | 10 | 183335 | 431 | 70744668 |
Menometrorrhagia | 12.84 | 9.63 | 12 | 183333 | 666 | 70744433 |
Priapism | 12.82 | 9.63 | 31 | 183314 | 4079 | 70741020 |
Hypogammaglobulinaemia | 12.68 | 9.63 | 7 | 183338 | 11531 | 70733568 |
Anxiety disorder | 12.67 | 9.63 | 30 | 183315 | 3895 | 70741204 |
Electroencephalogram abnormal | 12.66 | 9.63 | 36 | 183309 | 5222 | 70739877 |
Alcohol poisoning | 12.64 | 9.63 | 32 | 183313 | 4333 | 70740766 |
Respiratory disorder | 12.64 | 9.63 | 55 | 183290 | 39068 | 70706031 |
Hot flush | 12.59 | 9.63 | 189 | 183156 | 49395 | 70695704 |
Hyperventilation | 12.52 | 9.63 | 44 | 183301 | 7142 | 70737957 |
Drug eruption | 12.47 | 9.63 | 56 | 183289 | 39440 | 70705659 |
Pelvic pain | 12.42 | 9.63 | 61 | 183284 | 11499 | 70733600 |
Peripheral sensory neuropathy | 12.39 | 9.63 | 8 | 183337 | 12102 | 70732997 |
Nephrotic syndrome | 12.37 | 9.63 | 6 | 183339 | 10634 | 70734465 |
Complication of device insertion | 12.35 | 9.63 | 36 | 183309 | 5296 | 70739803 |
Cytopenia | 12.32 | 9.63 | 16 | 183329 | 17307 | 70727792 |
Anaphylactic reaction | 12.31 | 9.63 | 129 | 183216 | 74845 | 70670254 |
Attention-seeking behaviour | 12.28 | 9.63 | 6 | 183339 | 110 | 70744989 |
Dissociation | 12.22 | 9.63 | 27 | 183318 | 3349 | 70741750 |
Superior sagittal sinus thrombosis | 12.19 | 9.63 | 14 | 183331 | 990 | 70744109 |
Thrombotic microangiopathy | 12.17 | 9.63 | 17 | 183328 | 17831 | 70727268 |
Hepatitis chronic active | 12.16 | 9.63 | 7 | 183338 | 181 | 70744918 |
Joint hyperextension | 12.13 | 9.63 | 8 | 183337 | 265 | 70744834 |
Gastric cancer | 12.13 | 9.63 | 4 | 183341 | 8951 | 70736148 |
Illusion | 12.11 | 9.63 | 18 | 183327 | 1641 | 70743458 |
Cytotoxic oedema | 12.07 | 9.63 | 9 | 183336 | 364 | 70744735 |
Schizoaffective disorder | 12.06 | 9.63 | 20 | 183325 | 2003 | 70743096 |
Total lung capacity abnormal | 12.06 | 9.63 | 7 | 183338 | 184 | 70744915 |
Ejection fraction decreased | 12.04 | 9.63 | 40 | 183305 | 30722 | 70714377 |
Cognitive disorder | 12.03 | 9.63 | 223 | 183122 | 60733 | 70684366 |
Retinal ischaemia | 12.03 | 9.63 | 12 | 183333 | 722 | 70744377 |
Gastrointestinal haemorrhage | 12.01 | 9.63 | 267 | 183078 | 137141 | 70607958 |
Pulmonary arterial hypertension | 12.00 | 9.63 | 44 | 183301 | 32811 | 70712288 |
Coronary artery disease | 11.98 | 9.63 | 104 | 183241 | 62632 | 70682467 |
Hypercalcaemia | 11.94 | 9.63 | 47 | 183298 | 34338 | 70710761 |
Extensor plantar response | 11.94 | 9.63 | 18 | 183327 | 1662 | 70743437 |
Gastrointestinal disorder | 11.94 | 9.63 | 196 | 183149 | 105231 | 70639868 |
Gastrointestinal procedural complication | 11.92 | 9.63 | 7 | 183338 | 188 | 70744911 |
Mucormycosis | 11.92 | 9.63 | 3 | 183342 | 8011 | 70737088 |
Sperm concentration decreased | 11.78 | 9.63 | 5 | 183340 | 65 | 70745034 |
Laryngectomy | 11.72 | 9.63 | 4 | 183341 | 27 | 70745072 |
Retching | 11.65 | 9.63 | 76 | 183269 | 15903 | 70729196 |
Skin necrosis | 11.63 | 9.63 | 15 | 183330 | 16276 | 70728823 |
Polydipsia | 11.61 | 9.63 | 38 | 183307 | 5950 | 70739149 |
Anti-actin antibody positive | 11.60 | 9.63 | 3 | 183342 | 6 | 70745093 |
Wound healing normal | 11.60 | 9.63 | 3 | 183342 | 6 | 70745093 |
Bacteraemia | 11.55 | 9.63 | 38 | 183307 | 29271 | 70715828 |
Dermatitis atopic | 11.50 | 9.63 | 50 | 183295 | 8957 | 70736142 |
Gambling | 11.49 | 9.63 | 8 | 183337 | 290 | 70744809 |
Female orgasmic disorder | 11.48 | 9.63 | 4 | 183341 | 29 | 70745070 |
Flat affect | 11.45 | 9.63 | 19 | 183326 | 1904 | 70743195 |
Cardiac arrest | 11.44 | 9.63 | 514 | 182831 | 159320 | 70585779 |
Rash maculo-papular | 11.42 | 9.63 | 80 | 183265 | 50465 | 70694634 |
Endometrial disorder | 11.41 | 9.63 | 10 | 183335 | 510 | 70744589 |
Increased appetite | 11.40 | 9.63 | 56 | 183289 | 10557 | 70734542 |
Metabolic acidosis | 11.37 | 9.63 | 130 | 183215 | 74216 | 70670883 |
Enthesopathy | 11.37 | 9.63 | 7 | 183338 | 10862 | 70734237 |
Ejaculation disorder | 11.35 | 9.63 | 10 | 183335 | 514 | 70744585 |
Oedema peripheral | 11.33 | 9.63 | 478 | 182867 | 227613 | 70517486 |
Cholangitis | 11.32 | 9.63 | 8 | 183337 | 11541 | 70733558 |
Oedema | 11.26 | 9.63 | 194 | 183151 | 103387 | 70641712 |
Lactation disorder | 11.20 | 9.63 | 7 | 183338 | 211 | 70744888 |
Cataract | 11.18 | 9.63 | 91 | 183254 | 55554 | 70689545 |
Stoma site discharge | 11.16 | 9.63 | 18 | 183327 | 1761 | 70743338 |
Polyarthritis | 11.15 | 9.63 | 7 | 183338 | 10749 | 70734350 |
Inflammatory marker increased | 11.14 | 9.63 | 5 | 183340 | 9269 | 70735830 |
Sternal fracture | 11.12 | 9.63 | 21 | 183324 | 2330 | 70742769 |
Sialoadenitis | 11.07 | 9.63 | 18 | 183327 | 1774 | 70743325 |
Lactic acidosis | 11.04 | 9.63 | 111 | 183234 | 64913 | 70680186 |
Dry mouth | 11.01 | 9.63 | 249 | 183096 | 70208 | 70674891 |
Burnout syndrome | 11.00 | 9.63 | 8 | 183337 | 311 | 70744788 |
Disorganised speech | 11.00 | 9.63 | 18 | 183327 | 1783 | 70743316 |
Angina unstable | 10.97 | 9.63 | 15 | 183330 | 15878 | 70729221 |
Metastases to lung | 10.94 | 9.63 | 16 | 183329 | 16468 | 70728631 |
Optic atrophy | 10.90 | 9.63 | 18 | 183327 | 1797 | 70743302 |
Coordination abnormal | 10.86 | 9.63 | 75 | 183270 | 15991 | 70729108 |
Myelodysplastic syndrome | 10.80 | 9.63 | 40 | 183305 | 29745 | 70715354 |
Posterior reversible encephalopathy syndrome | 10.79 | 9.63 | 30 | 183315 | 24372 | 70720727 |
Lung consolidation | 10.75 | 9.63 | 4 | 183341 | 8302 | 70736797 |
Diarrhoea | 10.74 | 9.63 | 1821 | 181524 | 781520 | 69963579 |
Carboxyhaemoglobin increased | 10.73 | 9.63 | 4 | 183341 | 36 | 70745063 |
Cytokine release syndrome | 10.65 | 9.63 | 34 | 183311 | 26433 | 70718666 |
Arthritis bacterial | 10.60 | 9.63 | 4 | 183341 | 8229 | 70736870 |
Blood urea nitrogen/creatinine ratio decreased | 10.57 | 9.63 | 5 | 183340 | 85 | 70745014 |
Suture rupture | 10.56 | 9.63 | 10 | 183335 | 564 | 70744535 |
Drug dependence | 10.56 | 9.63 | 145 | 183200 | 37176 | 70707923 |
Ileus | 10.56 | 9.63 | 30 | 183315 | 24207 | 70720892 |
Delusional disorder, erotomanic type | 10.54 | 9.63 | 4 | 183341 | 38 | 70745061 |
Merycism | 10.53 | 9.63 | 7 | 183338 | 235 | 70744864 |
Bile acid malabsorption | 10.53 | 9.63 | 7 | 183338 | 235 | 70744864 |
Hyperkalaemia | 10.53 | 9.63 | 203 | 183142 | 106388 | 70638711 |
Homicide | 10.48 | 9.63 | 14 | 183331 | 1156 | 70743943 |
Staring | 10.47 | 9.63 | 21 | 183324 | 2435 | 70742664 |
Blood pressure diastolic decreased | 10.45 | 9.63 | 33 | 183312 | 25747 | 70719352 |
Creatinine urine decreased | 10.40 | 9.63 | 7 | 183338 | 240 | 70744859 |
Bronchiectasis | 10.32 | 9.63 | 16 | 183329 | 16081 | 70729018 |
Female sexual dysfunction | 10.27 | 9.63 | 4 | 183341 | 41 | 70745058 |
Shoulder deformity | 10.27 | 9.63 | 4 | 183341 | 41 | 70745058 |
Pseudomonas infection | 10.27 | 9.63 | 21 | 183324 | 18973 | 70726126 |
Eosinophil count increased | 10.26 | 9.63 | 71 | 183274 | 15151 | 70729948 |
Nephropathy | 10.22 | 9.63 | 5 | 183340 | 8820 | 70736279 |
Foreign body in reproductive tract | 10.22 | 9.63 | 9 | 183336 | 462 | 70744637 |
Nuchal rigidity | 10.22 | 9.63 | 13 | 183332 | 1023 | 70744076 |
Tension headache | 10.20 | 9.63 | 26 | 183319 | 3535 | 70741564 |
Paraesthesia | 10.19 | 9.63 | 467 | 182878 | 145070 | 70600029 |
Cerebellar haematoma | 10.10 | 9.63 | 10 | 183335 | 596 | 70744503 |
Antipsychotic drug level increased | 10.08 | 9.63 | 34 | 183311 | 5406 | 70739693 |
Xerophthalmia | 10.05 | 9.63 | 10 | 183335 | 600 | 70744499 |
Blood alcohol increased | 10.05 | 9.63 | 14 | 183331 | 1203 | 70743896 |
Amenorrhoea | 10.05 | 9.63 | 40 | 183305 | 6890 | 70738209 |
Injury | 10.02 | 9.63 | 230 | 183115 | 65015 | 70680084 |
Asphyxia | 10.01 | 9.63 | 53 | 183292 | 10289 | 70734810 |
Erection increased | 10.01 | 9.63 | 8 | 183337 | 359 | 70744740 |
Colitis | 9.99 | 9.63 | 111 | 183234 | 63703 | 70681396 |
Delusion of grandeur | 9.94 | 9.63 | 12 | 183333 | 895 | 70744204 |
Exposure via breast milk | 9.94 | 9.63 | 12 | 183333 | 895 | 70744204 |
Substance abuse | 9.93 | 9.63 | 51 | 183294 | 9786 | 70735313 |
Emotional poverty | 9.91 | 9.63 | 11 | 183334 | 749 | 70744350 |
Hypochloraemia | 9.91 | 9.63 | 19 | 183326 | 2132 | 70742967 |
Antidepressant discontinuation syndrome | 9.89 | 9.63 | 3 | 183342 | 13 | 70745086 |
Hyperdynamic left ventricle | 9.89 | 9.63 | 8 | 183337 | 365 | 70744734 |
Pulmonary hypertension | 9.87 | 9.63 | 75 | 183270 | 46461 | 70698638 |
Cardiogenic shock | 9.85 | 9.63 | 140 | 183205 | 36167 | 70708932 |
Anal stenosis | 9.82 | 9.63 | 8 | 183337 | 369 | 70744730 |
Hypocoagulable state | 9.80 | 9.63 | 18 | 183327 | 1955 | 70743144 |
Pulmonary tuberculosis | 9.79 | 9.63 | 4 | 183341 | 7841 | 70737258 |
Peripheral venous disease | 9.71 | 9.63 | 8 | 183337 | 10679 | 70734420 |
Aversion | 9.71 | 9.63 | 4 | 183341 | 48 | 70745051 |
Blood gases abnormal | 9.66 | 9.63 | 13 | 183332 | 1081 | 70744018 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Human herpesvirus 6 infection | 34.80 | 32.07 | 15 | 835 | 45 | 88897 |
Source | Code | Description |
---|---|---|
ATC | N06AB10 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Selective serotonin reuptake inhibitors |
FDA MoA | N0000000109 | Serotonin Uptake Inhibitors |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D017367 | Serotonin Uptake Inhibitors |
FDA EPC | N0000175696 | Serotonin Reuptake Inhibitor |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:76779 | post-proline endopeptidase inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Generalized anxiety disorder | indication | 21897009 | DOID:14320 |
Major depressive disorder | indication | 370143000 | |
Posttraumatic stress disorder | off-label use | 47505003 | DOID:2055 |
Bipolar affective disorder, current episode depression | off-label use | 191627008 | DOID:3312 |
Obsessive-compulsive disorder | off-label use | 191736004 | DOID:10933 |
Menopausal flushing | off-label use | 198436008 | |
Panic disorder | off-label use | 371631005 | DOID:594 |
Suicidal thoughts | contraindication | 6471006 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Upper gastrointestinal hemorrhage | contraindication | 37372002 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Heart disease | contraindication | 56265001 | DOID:114 |
Acute nephropathy | contraindication | 58574008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Hyponatremia | contraindication | 89627008 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Serotonin syndrome | contraindication | 371089000 | |
Myocardial infarction in recovery phase | contraindication | 418044006 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.33 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Ki | 8.96 | WOMBAT-PK | CHEMBL | |||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.19 | PDSP | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.60 | PDSP | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 5.41 | PDSP | |||||
Histamine H1 receptor | GPCR | Ki | 5.71 | PDSP | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 5.91 | PDSP | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 9.05 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 5.09 | CHEMBL | |||||
Transporter | Transporter | Ki | 4.98 | CHEMBL |
ID | Source |
---|---|
4024285 | VUID |
N0000022289 | NUI |
D02567 | KEGG_DRUG |
219861-08-2 | SECONDARY_CAS_RN |
4021356 | VANDF |
4024285 | VANDF |
C1099456 | UMLSCUI |
CHEBI:36791 | CHEBI |
CHEMBL1508 | ChEMBL_ID |
DB01175 | DRUGBANK_ID |
CHEMBL1200322 | ChEMBL_ID |
D000089983 | MESH_DESCRIPTOR_UI |
146570 | PUBCHEM_CID |
7177 | IUPHAR_LIGAND_ID |
7953 | INN_ID |
4O4S742ANY | UNII |
321988 | RXNORM |
158618 | MMSL |
16927 | MMSL |
187848 | MMSL |
d04812 | MMSL |
009709 | NDDF |
009710 | NDDF |
395246009 | SNOMEDCT_US |
400447003 | SNOMEDCT_US |
412384000 | SNOMEDCT_US |
68P | PDB_CHEM_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Escitalopram Oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0852 | SOLUTION | 10 mg | ORAL | ANDA | 36 sections |
Escitalopram Oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0852 | SOLUTION | 10 mg | ORAL | ANDA | 36 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2005 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2005 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2010 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2010 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2020 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2020 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 32 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2101 | SOLUTION | 5 mg | ORAL | NDA | 32 sections |
Lexapro | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-2101 | SOLUTION | 5 mg | ORAL | NDA | 32 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7953 | TABLET | 5 mg | ORAL | ANDA | 31 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7954 | TABLET | 10 mg | ORAL | ANDA | 31 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7955 | TABLET | 20 mg | ORAL | ANDA | 31 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8348 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 31 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8349 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8350 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 31 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8365 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
Escitalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8366 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 31 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6426 | TABLET | 10 mg | ORAL | ANDA | 30 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6426 | TABLET | 10 mg | ORAL | ANDA | 30 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6427 | TABLET | 20 mg | ORAL | ANDA | 30 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6427 | TABLET | 20 mg | ORAL | ANDA | 30 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-224 | TABLET | 5 mg | ORAL | ANDA | 29 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-225 | TABLET | 10 mg | ORAL | ANDA | 29 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-230 | TABLET | 20 mg | ORAL | ANDA | 29 sections |
Escitalopram Oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-968 | TABLET, FILM COATED | 10 mg | ORAL | NDA authorized generic | 32 sections |
Escitalopram Oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-969 | TABLET, FILM COATED | 20 mg | ORAL | NDA authorized generic | 32 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-135 | TABLET | 5 mg | ORAL | ANDA | 28 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-135 | TABLET | 5 mg | ORAL | ANDA | 28 sections |
escitalopram oxalate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-135 | TABLET | 5 mg | ORAL | ANDA | 28 sections |