All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

eplerenone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
aldosterone antagonists, spironolactone derivates	1032	107724-20-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: eplerenone (+)-Eplerenone epoxymexrenone	A spironolactone derivative and selective ALDOSTERONE RECEPTOR antagonist that is used in the management of HYPERTENSION and CONGESTIVE HEART FAILURE, post-MYOCARDIAL INFARCTION. Molecular weight: 414.50 Formula: C24H30O6 CLOGP: 0.47 LIPINSKI: 0 HAC: 6 HDO: 0 TPSA: 82.20 ALOGS: -4.66 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
50	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	3 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	1.72 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	69 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Sept. 27, 2002	FDA	GD SEARLE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	181.79	20.96	104	4693	75936	50524391
Hyperkalaemia	107.36	20.96	63	4734	48026	50552301
Acute kidney injury	103.15	20.96	117	4680	227941	50372386
Cardiac failure chronic	87.34	20.96	26	4771	3537	50596790
Subclavian vein thrombosis	80.30	20.96	21	4776	1778	50598549
Atrial fibrillation	68.99	20.96	65	4732	101680	50498647
Hypotension	59.70	20.96	91	4706	235378	50364949
Drug interaction	59.07	20.96	83	4714	199538	50400789
Hyponatraemia	53.20	20.96	55	4742	96084	50504243
Hydrothorax	44.82	20.96	11	4786	720	50599607
Cardiomyopathy	44.44	20.96	24	4773	15562	50584765
Femoral neck fracture	44.20	20.96	19	4778	7471	50592856
Embolism venous	43.22	20.96	14	4783	2511	50597816
Cardiac failure acute	42.43	20.96	19	4778	8231	50592096
Degenerative aortic valve disease	40.06	20.96	7	4790	82	50600245
Vascular stent thrombosis	37.64	20.96	10	4787	899	50599428
Oedema peripheral	35.71	20.96	58	4739	157903	50442424
Cardiac ventricular disorder	35.66	20.96	7	4790	160	50600167
Angina pectoris	35.28	20.96	25	4772	26163	50574164
Hypovolaemia	33.93	20.96	17	4780	9448	50590879
Ventricular tachycardia	30.78	20.96	19	4778	15802	50584525
Ejection fraction decreased	30.45	20.96	20	4777	18500	50581827
Subclavian artery thrombosis	29.57	20.96	6	4791	163	50600164
Left ventricular dysfunction	29.45	20.96	16	4781	10490	50589837
Left ventricular dilatation	29.10	20.96	7	4790	421	50599906
Pulmonary arterial pressure increased	28.33	20.96	11	4786	3337	50596990
N-terminal prohormone brain natriuretic peptide increased	27.32	20.96	9	4788	1701	50598626
Stenosis	26.26	20.96	8	4789	1175	50599152
Vascular purpura	26.05	20.96	8	4789	1206	50599121
Labelled drug-drug interaction medication error	24.05	20.96	14	4783	10463	50589864
Subdural haematoma	23.80	20.96	15	4782	12932	50587395
Arrhythmia	22.08	20.96	21	4776	33111	50567216
Therapeutic drug monitoring analysis not performed	21.06	20.96	6	4791	699	50599628

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	525.12	15.98	428	19211	78859	29476029
Cardiac failure chronic	356.07	15.98	141	19498	6326	29548562
Ventricular tachycardia	188.18	15.98	140	19499	22434	29532454
N-terminal prohormone brain natriuretic peptide increased	187.61	15.98	64	19575	1868	29553020
Acute kidney injury	182.77	15.98	483	19156	264784	29290104
Hyperkalaemia	170.82	15.98	207	19432	61185	29493703
Oedema peripheral	162.24	15.98	265	19374	103292	29451596
Hypotension	158.86	15.98	378	19261	193976	29360912
Glomerular filtration rate decreased	149.05	15.98	93	19546	11173	29543715
Dyspnoea	140.74	15.98	505	19134	326227	29228661
Ejection fraction decreased	132.91	15.98	99	19540	15879	29539009
Rales	114.75	15.98	68	19571	7442	29547446
Dyspnoea at rest	113.05	15.98	51	19588	3163	29551725
Mitral valve incompetence	109.73	15.98	82	19557	13211	29541677
Ventricular arrhythmia	104.18	15.98	54	19585	4550	29550338
Cardiac failure acute	97.32	15.98	66	19573	9126	29545762
Computerised tomogram coronary artery abnormal	94.80	15.98	23	19616	185	29554703
Renal impairment	81.60	15.98	172	19467	81161	29473727
Blood potassium increased	70.17	15.98	66	19573	14585	29540303
Liver palpable	68.44	15.98	19	19620	271	29554617
General physical health deterioration	65.01	15.98	182	19457	102675	29452213
Ventricular enlargement	63.78	15.98	20	19619	444	29554444
Electrocardiogram abnormal	62.27	15.98	46	19593	7276	29547612
Atrial fibrillation	61.02	15.98	181	19458	105465	29449423
Exercise tolerance decreased	58.66	15.98	36	19603	4195	29550693
Congestive cardiomyopathy	57.17	15.98	42	19597	6588	29548300
Febrile neutropenia	56.15	15.98	5	19634	112235	29442653
Drug interaction	55.24	15.98	268	19371	197117	29357771
Blood pressure decreased	54.94	15.98	104	19535	45373	29509515
Low cardiac output syndrome	54.18	15.98	18	19621	483	29554405
Hepatic vein dilatation	53.84	15.98	15	19624	217	29554671
Dyspnoea exertional	53.76	15.98	91	19548	36399	29518489
Gynaecomastia	53.34	15.98	44	19595	8173	29546715
Atrial enlargement	52.50	15.98	16	19623	322	29554566
Bradycardia	51.52	15.98	126	19513	65503	29489385
Death	50.68	15.98	94	19545	341990	29212898
Left atrial enlargement	50.62	15.98	19	19620	734	29554154
Dizziness	50.53	15.98	254	19385	189430	29365458
Respiratory tract haemorrhage	49.49	15.98	20	19619	944	29553944
Inferior vena cava dilatation	48.88	15.98	18	19621	659	29554229
Type V hyperlipidaemia	48.36	15.98	18	19621	679	29554209
Venous pressure jugular increased	47.58	15.98	18	19621	711	29554177
Oesophageal perforation	46.96	15.98	18	19621	737	29554151
Blood creatinine increased	46.46	15.98	143	19496	84959	29469929
Soft tissue mass	46.25	15.98	17	19622	619	29554269
Multimorbidity	44.71	15.98	16	19623	539	29554349
Atrial tachycardia	44.58	15.98	23	19616	1918	29552970
Concomitant disease aggravated	43.97	15.98	32	19607	4946	29549942
Jugular vein distension	42.85	15.98	16	19623	609	29554279
Orthopnoea	41.85	15.98	30	19609	4530	29550358
Blood pressure systolic decreased	41.63	15.98	28	19611	3816	29551072
Waist circumference increased	39.98	15.98	16	19623	736	29554152
Hyperuricaemia	38.80	15.98	34	19605	6855	29548033
Cardiogenic shock	38.22	15.98	55	19584	19135	29535753
Pulmonary arterial pressure increased	37.45	15.98	17	19622	1069	29553819
Labelled drug-drug interaction medication error	37.02	15.98	43	19596	12116	29542772
Tricuspid valve incompetence	36.75	15.98	36	19603	8358	29546530
Electrolyte imbalance	36.23	15.98	41	19598	11233	29543655
Ischaemic cardiomyopathy	36.19	15.98	30	19609	5608	29549280
Seizure	35.56	15.98	9	19630	93114	29461774
Mitral valve thickening	34.82	15.98	12	19627	361	29554527
Pulmonary oedema	33.46	15.98	82	19557	42653	29512235
Ventricular dyskinesia	32.64	15.98	10	19629	205	29554683
Blood thyroid stimulating hormone increased	32.16	15.98	22	19617	3083	29551805
White blood cell count decreased	31.94	15.98	8	19631	83354	29471534
Left ventricular enlargement	31.66	15.98	13	19626	639	29554249
Arthralgia	31.30	15.98	28	19611	139589	29415299
Neutropenia	31.25	15.98	25	19614	131686	29423202
Venous pressure jugular decreased	30.92	15.98	7	19632	40	29554848
Breath sounds abnormal	30.86	15.98	27	19612	5430	29549458
Cardiac amyloidosis	30.71	15.98	14	19625	889	29553999
Syncope	30.70	15.98	121	19518	81250	29473638
Hyperthyroidism	30.59	15.98	33	19606	8575	29546313
Superinfection	30.25	15.98	18	19621	1983	29552905
Right ventricular dysfunction	29.99	15.98	14	19625	939	29553949
Arrhythmia	29.93	15.98	65	19574	31248	29523640
Pyrexia	28.50	15.98	97	19542	287525	29267363
Pyonephrosis	28.35	15.98	7	19632	61	29554827
Left ventricular dysfunction	27.97	15.98	32	19607	8870	29546018
Blood pressure inadequately controlled	27.33	15.98	18	19621	2368	29552520
Coronary artery stenosis	27.25	15.98	31	19608	8542	29546346
Cardiac ventricular thrombosis	27.11	15.98	13	19626	926	29553962
Mitral valve calcification	27.10	15.98	11	19628	525	29554363
Glomerular filtration rate abnormal	26.78	15.98	12	19627	732	29554156
Oesophageal carcinoma	26.73	15.98	23	19616	4524	29550364
Transplant failure	26.69	15.98	19	19620	2837	29552051
Malignant neoplasm progression	26.58	15.98	8	19631	73851	29481037
Immunosuppressant drug level increased	25.80	15.98	23	19616	4742	29550146
Product prescribing error	25.36	15.98	44	19595	17932	29536956
Weight increased	24.98	15.98	109	19530	76558	29478330
Myocardial ischaemia	24.96	15.98	41	19598	15987	29538901
N-terminal prohormone brain natriuretic peptide abnormal	24.96	15.98	8	19631	191	29554697
Arterial intramural haematoma	24.76	15.98	6	19633	48	29554840
Rash	24.74	15.98	56	19583	189763	29365125
Brain natriuretic peptide increased	24.06	15.98	21	19618	4209	29550679
Drug ineffective	23.68	15.98	143	19496	363027	29191861
Cardiomyopathy	23.26	15.98	38	19601	14749	29540139
Hypothyroidism	22.53	15.98	39	19600	15867	29539021
Right ventricular failure	22.52	15.98	27	19612	7863	29547025
Cardiomegaly	22.49	15.98	36	19603	13740	29541148
Atrial flutter	22.26	15.98	36	19603	13858	29541030
Cardiac failure congestive	22.05	15.98	105	19534	76476	29478412
Hypotonia	22.01	15.98	25	19614	6877	29548011
Infection	21.65	15.98	12	19627	76739	29478149
Deep vein thrombosis	21.05	15.98	6	19633	57393	29497495
Pulmonary congestion	20.99	15.98	33	19606	12403	29542485
Palpitations	20.84	15.98	58	19581	32546	29522342
Ventricular hypokinesia	20.77	15.98	20	19619	4545	29550343
Non-compaction cardiomyopathy	20.74	15.98	5	19634	39	29554849
Blood lactic acid	20.63	15.98	8	19631	338	29554550
Asthma-chronic obstructive pulmonary disease overlap syndrome	20.59	15.98	10	19629	733	29554155
Atrial thrombosis	20.35	15.98	14	19625	1979	29552909
Adrenocortical insufficiency acute	20.28	15.98	12	19627	1308	29553580
Glycosylated haemoglobin increased	20.22	15.98	28	19611	9398	29545490
Ureteric haemorrhage	20.21	15.98	6	19633	110	29554778
Neuropathy peripheral	20.19	15.98	11	19628	71016	29483872
Leukopenia	19.82	15.98	6	19633	55197	29499691
Pleural effusion	19.56	15.98	97	19542	71811	29483077
Cardiac dysfunction	19.18	15.98	13	19626	1794	29553094
Neutrophil count decreased	19.15	15.98	3	19636	43564	29511324
Chronic kidney disease	18.74	15.98	60	19579	36356	29518532
Abdominal distension	18.71	15.98	70	19569	45841	29509047
Hypertrophy	18.58	15.98	8	19631	443	29554445
Ascites	18.54	15.98	60	19579	36559	29518329
Left ventricular dilatation	18.51	15.98	9	19630	661	29554227
Sinus bradycardia	18.50	15.98	30	19609	11573	29543315
Inflammatory marker increased	18.48	15.98	17	19622	3650	29551238
Cardiac murmur	17.85	15.98	22	19617	6591	29548297
Brain natriuretic peptide abnormal	17.64	15.98	7	19632	315	29554573
Ventricular fibrillation	17.62	15.98	35	19604	15798	29539090
Oedema	17.57	15.98	63	19576	40420	29514468
Skin weeping	17.49	15.98	6	19633	178	29554710
Lung consolidation	17.34	15.98	19	19620	5024	29549864
Cardiovascular insufficiency	17.16	15.98	11	19628	1382	29553506
Dyspnoea paroxysmal nocturnal	17.16	15.98	11	19628	1383	29553505
Heart rate irregular	17.08	15.98	31	19608	13086	29541802
Bronchial hyperreactivity	17.07	15.98	11	19628	1395	29553493
Renal atrophy	17.01	15.98	10	19629	1077	29553811
Back pain	17	15.98	26	19613	102258	29452630
Gastric dilatation	16.88	15.98	8	19631	555	29554333
Coma	16.71	15.98	3	19636	39447	29515441
Conduction disorder	16.64	15.98	12	19627	1828	29553060
Bundle branch block left	16.63	15.98	19	19620	5258	29549630
Sudden cardiac death	16.36	15.98	15	19624	3207	29551681
Hyperaldosteronism	16.34	15.98	5	19634	102	29554786
Alanine aminotransferase increased	16.15	15.98	14	19625	70930	29483958
Pancytopenia	15.99	15.98	19	19620	83149	29471739

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	725.01	16.12	492	21893	131881	64344466
Cardiac failure chronic	472.75	16.12	160	22225	8881	64467466
Acute kidney injury	344.62	16.12	582	21803	448658	64027689
Hyperkalaemia	288.87	16.12	256	22129	100873	64375474
Ventricular tachycardia	229.91	16.12	145	22240	34120	64442227
Hypotension	222.16	16.12	439	21946	380535	64095812
Oedema peripheral	189.70	16.12	294	22091	210023	64266324
Glomerular filtration rate decreased	186.77	16.12	104	22281	19468	64456879
N-terminal prohormone brain natriuretic peptide increased	186.03	16.12	63	22322	3496	64472851
Ejection fraction decreased	161.96	16.12	109	22276	28598	64447749
Cardiac failure acute	150.91	16.12	85	22300	16259	64460088
Atrial fibrillation	141.49	16.12	230	22155	170859	64305488
Dyspnoea	134.79	16.12	548	21837	718126	63758221
Drug interaction	122.11	16.12	337	22048	361746	64114601
Mitral valve incompetence	113.90	16.12	84	22301	25454	64450893
Ventricular arrhythmia	109.96	16.12	53	22332	7362	64468985
Computerised tomogram coronary artery abnormal	109.66	16.12	23	22362	185	64476162
Dyspnoea at rest	108.50	16.12	50	22335	6279	64470068
Rales	106.00	16.12	66	22319	15163	64461184
Renal impairment	104.14	16.12	176	22209	134841	64341506
Exercise tolerance decreased	81.91	16.12	44	22341	7666	64468681
Liver palpable	77.29	16.12	19	22366	328	64476019
Congestive cardiomyopathy	74.95	16.12	46	22339	10298	64466049
Blood potassium increased	74.47	16.12	66	22319	25914	64450433
Bradycardia	74.31	16.12	141	22244	118078	64358269
Ventricular enlargement	69.56	16.12	19	22366	504	64475843
Blood creatinine increased	66.44	16.12	146	22239	135636	64340711
Atrial enlargement	65.18	16.12	19	22366	641	64475706
Cardiomyopathy	64.03	16.12	60	22325	25296	64451051
Electrocardiogram abnormal	63.86	16.12	46	22339	13435	64462912
Blood pressure decreased	63.29	16.12	110	22275	86089	64390258
Hepatic vein dilatation	62.50	16.12	15	22370	233	64476114
General physical health deterioration	61.63	16.12	183	22202	204242	64272105
Labelled drug-drug interaction medication error	61.15	16.12	55	22330	22007	64454340
Respiratory tract haemorrhage	61.13	16.12	22	22363	1462	64474885
Inferior vena cava dilatation	58.43	16.12	18	22367	736	64475611
Low cardiac output syndrome	57.49	16.12	18	22367	777	64475570
Left atrial enlargement	56.82	16.12	19	22366	1013	64475334
Pulmonary arterial pressure increased	56.76	16.12	28	22357	4088	64472259
Left ventricular dysfunction	56.58	16.12	47	22338	16907	64459440
Cardiogenic shock	55.11	16.12	62	22323	32365	64443982
Type V hyperlipidaemia	54.86	16.12	18	22367	904	64475443
Gynaecomastia	54.74	16.12	31	22354	5985	64470362
Orthopnoea	54.67	16.12	36	22349	9098	64467249
Oesophageal perforation	52.72	16.12	18	22367	1023	64475324
Soft tissue mass	51.10	16.12	17	22368	892	64475455
Hyperuricaemia	51.09	16.12	36	22349	10155	64466192
Venous pressure jugular increased	49.32	16.12	18	22367	1245	64475102
Dyspnoea exertional	48.87	16.12	90	22295	73640	64402707
Arthralgia	48.79	16.12	49	22336	442211	64034136
Left ventricular dilatation	46.75	16.12	16	22369	916	64475431
Ischaemic cardiomyopathy	45.98	16.12	29	22356	6809	64469538
Hyponatraemia	45.82	16.12	134	22251	148205	64328142
Multimorbidity	45.46	16.12	16	22369	996	64475351
Rheumatoid arthritis	45.25	16.12	3	22382	164291	64312056
Febrile neutropenia	44.90	16.12	6	22379	187651	64288696
Concomitant disease aggravated	44.89	16.12	35	22350	11507	64464840
Tricuspid valve incompetence	44.41	16.12	41	22344	16962	64459385
Blood pressure systolic decreased	43.85	16.12	31	22354	8789	64467558
Left ventricular enlargement	43.32	16.12	14	22371	670	64475677
Pain	42.31	16.12	80	22305	553431	63922916
Coronary artery stenosis	41.36	16.12	33	22352	11215	64465132
Jugular vein distension	41.29	16.12	16	22369	1306	64475041
Waist circumference increased	40.73	16.12	16	22369	1355	64474992
Dizziness	40.20	16.12	271	22114	429892	64046455
Cardiomegaly	39.76	16.12	45	22340	23639	64452708
Arrhythmia	39.41	16.12	68	22317	52876	64423471
Oesophageal carcinoma	39.31	16.12	23	22362	4720	64471627
Syncope	39.11	16.12	132	22253	157503	64318844
Electrolyte imbalance	39.08	16.12	46	22339	25197	64451150
Renal failure	38.95	16.12	145	22240	181543	64294804
Cardiac failure congestive	37.52	16.12	115	22270	130465	64345882
N-terminal prohormone brain natriuretic peptide abnormal	37.40	16.12	10	22375	244	64476103
Immunosuppressant drug level increased	37.22	16.12	26	22359	7233	64469114
Mitral valve thickening	37.21	16.12	11	22374	390	64475957
Rash	37.05	16.12	64	22321	458485	64017862
Hyperthyroidism	36.56	16.12	38	22347	18141	64458206
Brain natriuretic peptide increased	36.04	16.12	26	22359	7607	64468740
Pulmonary oedema	34.45	16.12	81	22304	78593	64397754
Cardiac ventricular disorder	34.43	16.12	10	22375	333	64476014
Joint swelling	34.16	16.12	16	22369	215366	64260981
Hypovolaemia	34.11	16.12	34	22351	15452	64460895
Ventricular extrasystoles	34.11	16.12	36	22349	17493	64458854
Transplant failure	33.04	16.12	19	22366	3775	64472572
Ventricular dyskinesia	32.72	16.12	10	22375	398	64475949
Drug abuse	32.22	16.12	4	22381	132370	64343977
Breath sounds abnormal	32.15	16.12	29	22356	11640	64464707
Infection	32.11	16.12	12	22373	184868	64291479
Sinusitis	31.89	16.12	6	22379	145922	64330425
Glomerular filtration rate abnormal	31.55	16.12	13	22372	1246	64475101
Ventricular fibrillation	31.30	16.12	40	22345	23820	64452527
Ventricular hypokinesia	31.17	16.12	24	22361	7745	64468602
Venous pressure jugular decreased	30.84	16.12	7	22378	84	64476263
Pyonephrosis	30.54	16.12	7	22378	88	64476259
Hypersensitivity	30.53	16.12	15	22370	196437	64279910
Pleural effusion	30.52	16.12	105	22280	126454	64349893
Stenosis	30.05	16.12	14	22371	1801	64474546
Cardiac ventricular thrombosis	30.04	16.12	13	22372	1407	64474940
Superinfection	30.00	16.12	18	22367	3868	64472479
Angina pectoris	29.82	16.12	55	22330	45026	64431321
Back pain	29.56	16.12	26	22359	250145	64226202
Blood thyroid stimulating hormone increased	29.31	16.12	23	22362	7631	64468716
Degenerative aortic valve disease	28.97	16.12	7	22378	112	64476235
Arthropathy	28.61	16.12	4	22381	120963	64355384
Alopecia	28.36	16.12	11	22374	165679	64310668
Pulmonary congestion	28.17	16.12	38	22347	23842	64452505
Chronic kidney disease	27.97	16.12	62	22323	57857	64418490
Cardiovascular insufficiency	27.94	16.12	15	22370	2609	64473738
Atrial flutter	27.84	16.12	34	22351	19346	64457001
Myocardial ischaemia	27.43	16.12	37	22348	23214	64453133
Product prescribing error	27.17	16.12	46	22339	35223	64441124
Seizure	27.08	16.12	12	22373	166880	64309467
Musculoskeletal stiffness	27.06	16.12	5	22380	123201	64353146
Mitral valve calcification	27.00	16.12	12	22373	1384	64474963
Subclavian vein thrombosis	26.82	16.12	14	22371	2300	64474047
Dehydration	26.82	16.12	147	22238	216616	64259731
Drug ineffective	26.54	16.12	177	22208	840070	63636277
Arterial intramural haematoma	26.28	16.12	6	22379	74	64476273
Subdural haematoma	26.28	16.12	40	22345	28014	64448333
Atrial tachycardia	26.22	16.12	16	22369	3543	64472804
Asthma-chronic obstructive pulmonary disease overlap syndrome	26.12	16.12	11	22374	1114	64475233
Atrial thrombosis	25.87	16.12	15	22370	3027	64473320
Hypotonia	25.41	16.12	25	22360	11187	64465160
Hydrothorax	24.94	16.12	11	22374	1246	64475101
Pain in extremity	24.72	16.12	42	22343	303043	64173304
Right ventricular dysfunction	24.60	16.12	13	22372	2190	64474157
Rash scarlatiniform	24.22	16.12	7	22378	229	64476118
Ascites	24.11	16.12	61	22324	61940	64414407
Non-compaction cardiomyopathy	23.97	16.12	5	22380	39	64476308
Neutropenia	23.68	16.12	29	22356	239595	64236752
Right ventricular failure	23.57	16.12	33	22352	21438	64454909
Blood lactic acid	23.42	16.12	8	22377	455	64475892
Drug hypersensitivity	23.27	16.12	29	22356	237786	64238561
White blood cell count decreased	23.12	16.12	13	22372	157824	64318523
Injection site pain	21.51	16.12	6	22379	111402	64364945
Haematochezia	21.47	16.12	61	22324	66312	64410035
Headache	21.28	16.12	103	22282	529364	63946983
Acute pulmonary oedema	20.92	16.12	24	22361	12785	64463562
Lung consolidation	20.82	16.12	19	22366	7739	64468608
Femoral neck fracture	20.79	16.12	20	22365	8704	64467643
Sinus bradycardia	20.54	16.12	32	22353	22861	64453486
Cardiac dysfunction	20.45	16.12	13	22372	3093	64473254
Bronchial hyperreactivity	20.34	16.12	12	22373	2500	64473847
Adrenocortical insufficiency acute	20.11	16.12	12	22373	2553	64473794
Dyspnoea paroxysmal nocturnal	20.07	16.12	11	22374	1993	64474354
Hepatic enzyme increased	20.06	16.12	10	22375	129933	64346414
Aortic valve incompetence	19.73	16.12	19	22366	8282	64468065
Hypertrophy	19.56	16.12	8	22377	752	64475595
Vascular stent thrombosis	19.50	16.12	13	22372	3351	64472996
Cardiac murmur	19.45	16.12	22	22363	11541	64464806
Drug intolerance	19.37	16.12	22	22363	187970	64288377
Renal atrophy	19.10	16.12	10	22375	1654	64474693
Supraventricular extrasystoles	18.91	16.12	16	22369	5899	64470448
Heart rate irregular	18.83	16.12	34	22351	27379	64448968
Coma	18.31	16.12	4	22381	87611	64388736
Glycosylated haemoglobin increased	18.15	16.12	25	22360	15994	64460353
Hypothyroidism	18.08	16.12	42	22343	40415	64435932
Abdominal discomfort	18.07	16.12	22	22363	182300	64294047
Sudden cardiac death	18.03	16.12	14	22371	4573	64471774
Treatment failure	18.02	16.12	9	22376	116807	64359540
Deep vein thrombosis	17.96	16.12	7	22378	105175	64371172
Product monitoring error	17.95	16.12	15	22370	5439	64470908
Blood cyanide increased	17.94	16.12	4	22381	44	64476303
Urticaria	17.76	16.12	15	22370	147302	64329045
Anaemia	17.68	16.12	205	22180	378475	64097872
Blood potassium abnormal	17.60	16.12	11	22374	2541	64473806
Inflammatory marker increased	17.60	16.12	18	22367	8433	64467914
Limited symptom panic attack	17.47	16.12	4	22381	50	64476297
Heart rate abnormal	16.88	16.12	14	22371	5021	64471326
Brain natriuretic peptide abnormal	16.87	16.12	7	22378	683	64475664
Toxicity to various agents	16.84	16.12	67	22318	363446	64112901
Left atrial dilatation	16.79	16.12	11	22374	2755	64473592
Gastrointestinal haemorrhage	16.53	16.12	90	22295	132222	64344125
Gastric dilatation	16.20	16.12	8	22377	1170	64475177

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C03DA04	CARDIOVASCULAR SYSTEM DIURETICS ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS Aldosterone antagonists
FDA MoA	N0000011310	Aldosterone Antagonists
FDA EPC	N0000175557	Aldosterone Antagonist
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D004232	Diuretics
MeSH PA	D006727	Hormone Antagonists
MeSH PA	D000451	Mineralocorticoid Receptor Antagonists
MeSH PA	D045283	Natriuretic Agents
CHEBI has role	CHEBI:35674	antihypertensive drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Chronic Heart Failure Following Myocardial Infarction	indication
Hyperkalemia	contraindication	14140009
Diabetic renal disease	contraindication	127013003
Impaired renal function disorder	contraindication	197663003
Disease of liver	contraindication	235856003	DOID:409

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Mineralocorticoid receptor	Nuclear hormone receptor	P08235	MCR_HUMAN	ANTAGONIST	IC50	7		WOMBAT-PK	CHEMBL
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN		IC50	4.74		CHEMBL
Progesterone receptor	Nuclear hormone receptor	P06401	PRGR_HUMAN		Ki	4.70		CHEMBL
Mineralocorticoid receptor	Transcription factor		MCR_RAT		IC50	7.40		CHEMBL

External reference:

ID	Source
4021363	VUID
N0000148782	NUI
D01115	KEGG_DRUG
4021363	VANDF
C0961485	UMLSCUI
CHEBI:31547	CHEBI
YNU	PDB_CHEM_ID
CHEMBL1095097	ChEMBL_ID
D000077545	MESH_DESCRIPTOR_UI
DB00700	DRUGBANK_ID
C058465	MESH_SUPPLEMENTAL_RECORD_UI
443872	PUBCHEM_CID
2876	IUPHAR_LIGAND_ID
7596	INN_ID
6995V82D0B	UNII
298869	RXNORM
147386	MMSL
16969	MMSL
d04815	MMSL
009774	NDDF
398699008	SNOMEDCT_US
407010008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Inspra	HUMAN PRESCRIPTION DRUG LABEL	1	0025-1710	TABLET, FILM COATED	25 mg	ORAL	NDA	27 sections
Inspra	HUMAN PRESCRIPTION DRUG LABEL	1	0025-1720	TABLET, FILM COATED	50 mg	ORAL	NDA	27 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	0185-5368	TABLET	25 mg	ORAL	ANDA	25 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	0185-5369	TABLET	50 mg	ORAL	ANDA	25 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1030	TABLET, FILM COATED	25 mg	ORAL	ANDA	27 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1030	TABLET, FILM COATED	25 mg	ORAL	ANDA	27 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1031	TABLET, FILM COATED	50 mg	ORAL	ANDA	27 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1031	TABLET, FILM COATED	50 mg	ORAL	ANDA	27 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	16729-293	TABLET, FILM COATED	25 mg	ORAL	ANDA	26 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	16729-294	TABLET, FILM COATED	50 mg	ORAL	ANDA	26 sections
Inspra	HUMAN PRESCRIPTION DRUG LABEL	1	21695-797	TABLET	25 mg	ORAL	NDA	27 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	42254-011	TABLET	50 mg	ORAL	ANDA	23 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	42291-454	TABLET, COATED	25 mg	ORAL	ANDA	29 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	42291-455	TABLET, COATED	50 mg	ORAL	ANDA	29 sections
EPLERENONE	HUMAN PRESCRIPTION DRUG LABEL	1	51991-877	TABLET, FILM COATED	25 mg	ORAL	ANDA	27 sections
EPLERENONE	HUMAN PRESCRIPTION DRUG LABEL	1	51991-878	TABLET, FILM COATED	50 mg	ORAL	ANDA	27 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	54868-6065	TABLET	25 mg	ORAL	ANDA	23 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	59762-1710	TABLET, FILM COATED	25 mg	ORAL	NDA AUTHORIZED GENERIC	27 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	59762-1720	TABLET, FILM COATED	50 mg	ORAL	NDA AUTHORIZED GENERIC	27 sections
EPLERENONE	HUMAN PRESCRIPTION DRUG LABEL	1	60687-451	TABLET, FILM COATED	25 mg	ORAL	ANDA	27 sections
EPLERENONE	HUMAN PRESCRIPTION DRUG LABEL	1	60687-451	TABLET, FILM COATED	25 mg	ORAL	ANDA	27 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	66993-343	TABLET, FILM COATED	25 mg	ORAL	ANDA	26 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	66993-344	TABLET, FILM COATED	50 mg	ORAL	ANDA	26 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	69367-307	TABLET, COATED	25 mg	ORAL	ANDA	29 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	69367-308	TABLET, COATED	50 mg	ORAL	ANDA	29 sections
eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	70436-098	TABLET, FILM COATED	25 mg	ORAL	ANDA	26 sections
eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	70436-099	TABLET, FILM COATED	50 mg	ORAL	ANDA	26 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	71205-863	TABLET, COATED	25 mg	ORAL	ANDA	27 sections
Eplerenone	HUMAN PRESCRIPTION DRUG LABEL	1	71205-864	TABLET, COATED	50 mg	ORAL	ANDA	27 sections