eplerenone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
mineralocorticoid receptor (MR, MCR, aldosterone receptor) antagonists 1032 107724-20-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • eplerenone
  • (+)-Eplerenone
  • epoxymexrenone
A spironolactone derivative and selective ALDOSTERONE RECEPTOR antagonist that is used in the management of HYPERTENSION and CONGESTIVE HEART FAILURE, post-MYOCARDIAL INFARCTION.
  • Molecular weight: 414.50
  • Formula: C24H30O6
  • CLOGP: 0.47
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 82.20
  • ALOGS: -4.66
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 3 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.72 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 69 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.282 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.355 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 54.702 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 2.582 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 76.180 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 77.500 % High 1
herg hERG pIC50 4.382 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 0.925 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 4.207 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 74.520 % High 1
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK 18
kinase-selectivity-class GRK2 1
mh-clint Mouse hepatocyte intrinsic clearance 10.715 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 3.475 High 1
mppb Mouse plasma protein binding (% unbound) 65.630 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 7.430 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 81.330 % High 1
rat-kpuu-brain Rat brain Kpuu 0.187 % High 1
rh-clint Rat hepatocyte intrinsic clearance 4.406 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 91.540 % High 1
rppb Rat plasma protein binding (% unbound) 53.280 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 833.681 uM High 1

Approvals:

DateAgencyCompanyOrphan
Sept. 27, 2002 FDA GD SEARLE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure 282.95 20.40 154 7866 109342 90511085
Acute kidney injury 197.61 20.40 188 7832 320199 90300228
Hyperkalaemia 183.36 20.40 97 7923 64867 90555560
Drug interaction 115.69 20.40 132 7888 276321 90344106
Cardiac failure chronic 114.30 20.40 35 7985 5611 90614816
Atrial fibrillation 102.85 20.40 89 7931 133522 90486905
Hypotension 84.95 20.40 123 7897 325274 90295153
Subclavian vein thrombosis 78.33 20.40 21 7999 2095 90618332
Hyponatraemia 71.98 20.40 73 7947 133465 90486962
Cardiomyopathy 67.99 20.40 34 7986 20172 90600255
Vascular stent thrombosis 65.52 20.40 16 8004 1100 90619327
Oedema peripheral 63.63 20.40 95 7925 257820 90362607
Renal impairment 61.16 20.40 60 7960 105361 90515066
Femoral neck fracture 58.89 20.40 25 7995 10208 90610219
Dyspnoea 57.11 20.40 189 7831 880766 89739661
Hypocalcaemia 53.83 20.40 38 7982 42330 90578097
Tachypnoea 52.19 20.40 29 7991 21280 90599147
Orthopnoea 50.60 20.40 20 8000 6815 90613612
Wound haemorrhage 50.58 20.40 16 8004 2851 90617576
Bradycardia 49.14 20.40 48 7972 83799 90536628
Therapeutic drug monitoring analysis not performed 48.30 20.40 13 8007 1316 90619111
Degenerative aortic valve disease 47.47 20.40 9 8011 183 90620244
Cardiac failure acute 45.90 20.40 22 7998 11907 90608520
Ventricular tachycardia 45.63 20.40 28 7992 24680 90595747
Hydrothorax 41.79 20.40 11 8009 1022 90619405
Cardiac amyloidosis 41.76 20.40 11 8009 1025 90619402
Ejection fraction decreased 41.59 20.40 27 7993 26226 90594201
Hypomagnesaemia 40.82 20.40 30 7990 35558 90584869
Ventricular extrasystoles 40.79 20.40 21 7999 13229 90607198
Morganella infection 39.39 20.40 10 8010 806 90619621
Embolism venous 39.22 20.40 14 8006 3606 90616821
Glomerular filtration rate decreased 38.63 20.40 22 7998 16910 90603517
Cardiac ventricular disorder 35.90 20.40 7 8013 166 90620261
Hypophosphataemia 35.78 20.40 20 8000 14834 90605593
Exercise tolerance decreased 35.50 20.40 16 8004 7535 90612892
Supraventricular extrasystoles 34.14 20.40 14 8006 5243 90615184
Hypovolaemia 33.43 20.40 18 8002 12413 90608014
Pulmonary congestion 33.29 20.40 21 7999 19412 90601015
Congestive cardiomyopathy 32.73 20.40 15 8005 7339 90613088
Fall 32.51 20.40 105 7915 481705 90138722
Angina pectoris 31.93 20.40 27 7993 39133 90581294
Therapeutic drug monitoring analysis incorrectly performed 31.16 20.40 7 8013 334 90620093
Joint swelling 31.00 20.40 4 8016 503296 90117131
Coronary artery occlusion 30.57 20.40 15 8005 8539 90611888
Mitral valve incompetence 30.47 20.40 21 7999 22503 90597924
Hypokalaemia 30.43 20.40 47 7973 131069 90489358
N-terminal prohormone brain natriuretic peptide increased 30.38 20.40 11 8009 2951 90617476
Dizziness 29.96 20.40 117 7903 589167 90031260
Dermo-hypodermitis 29.83 20.40 8 8012 799 90619628
Subclavian artery thrombosis 29.22 20.40 6 8014 186 90620241
Subdural haematoma 28.55 20.40 18 8002 16627 90603800
Melaena 28.39 20.40 24 7996 34773 90585654
Polyuria 28.30 20.40 15 8005 10025 90610402
Left ventricular dysfunction 28.04 20.40 17 8003 14652 90605775
Pulmonary arterial pressure increased 27.39 20.40 11 8009 3905 90616522
Ventricular hypokinesia 27.29 20.40 12 8008 5329 90615098
Left ventricular dilatation 26.51 20.40 7 8013 658 90619769
Renal failure 26.35 20.40 44 7976 130963 90489464
Glomerular filtration rate increased 26.28 20.40 9 8011 2051 90618376
Stenosis 26.18 20.40 9 8011 2075 90618352
Blood creatinine increased 24.44 20.40 37 7983 101349 90519078
Arrhythmia 24.35 20.40 24 7996 42308 90578119
Vascular purpura 23.77 20.40 8 8012 1730 90618697
Embolic stroke 23.60 20.40 10 8010 4062 90616365
Electrocardiogram Q wave abnormal 23.52 20.40 5 8015 184 90620243
Cardiac aneurysm 23.47 20.40 7 8013 1025 90619402
Blood uric acid increased 23.11 20.40 12 8008 7692 90612735
Haematoma 22.20 20.40 22 7998 39026 90581401
Blood pressure decreased 21.96 20.40 30 7990 74865 90545562
Blood bilirubin unconjugated decreased 21.89 20.40 4 8016 66 90620361
Hepatic enzyme increased 21.88 20.40 3 8017 360733 90259694
Bicytopenia 20.99 20.40 9 8011 3762 90616665
Blood urea increased 20.84 20.40 19 8001 30394 90590033
Labelled drug-drug interaction medication error 20.68 20.40 14 8006 14568 90605859
Sinusitis 20.46 20.40 3 8017 343085 90277342
Tachyphylaxis 20.41 20.40 5 8015 348 90620079

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure 715.85 15.50 581 27743 106275 42486736
Cardiac failure chronic 451.62 15.50 187 28137 9414 42583597
Acute kidney injury 308.03 15.50 721 27603 366616 42226395
Ventricular tachycardia 266.96 15.50 194 28130 29966 42563045
Rales 250.23 15.50 131 28193 11269 42581742
Hypotension 246.99 15.50 534 27790 257097 42335914
Hyperkalaemia 228.06 15.50 274 28050 80184 42512827
Ejection fraction decreased 227.74 15.50 156 28168 21931 42571080
Oedema peripheral 219.41 15.50 353 27971 135723 42457288
N-terminal prohormone brain natriuretic peptide increased 192.40 15.50 76 28248 3377 42589634
Mitral valve incompetence 188.04 15.50 124 28200 16365 42576646
Dyspnoea 170.76 15.50 661 27663 441960 42151051
Glomerular filtration rate decreased 144.20 15.50 105 28219 16246 42576765
Dyspnoea at rest 132.41 15.50 62 28262 4187 42588824
Exercise tolerance decreased 125.41 15.50 67 28257 5999 42587012
Dyspnoea exertional 112.24 15.50 152 28172 49996 42543015
Tricuspid valve incompetence 110.99 15.50 77 28247 11036 42581975
Ventricular enlargement 108.92 15.50 33 28291 650 42592361
Atrial fibrillation 108.57 15.50 267 28057 139326 42453685
Bradycardia 107.64 15.50 199 28125 85285 42507726
Ventricular arrhythmia 106.85 15.50 61 28263 6218 42586793
Cardiac failure acute 105.59 15.50 81 28243 13552 42579459
Renal impairment 103.42 15.50 227 28097 110001 42483010
Atrial enlargement 102.60 15.50 32 28292 697 42592314
Congestive cardiomyopathy 102.55 15.50 67 28257 8697 42584314
Ischaemic cardiomyopathy 94.25 15.50 57 28267 6465 42586546
Soft tissue mass 84.63 15.50 30 28294 982 42592029
Febrile neutropenia 83.66 15.50 12 28312 185691 42407320
Multimorbidity 83.03 15.50 29 28295 908 42592103
Oesophageal perforation 82.46 15.50 31 28293 1202 42591809
Computerised tomogram coronary artery abnormal 75.28 15.50 18 28306 135 42592876
Renal phospholipidosis 74.93 15.50 18 28306 138 42592873
Cardiac amyloidosis 74.26 15.50 33 28291 1972 42591039
Low cardiac output syndrome 72.72 15.50 24 28300 630 42592381
Blood pressure decreased 72.38 15.50 135 28189 58197 42534814
Death 70.33 15.50 129 28195 471056 42121955
Liver palpable 67.92 15.50 19 28305 279 42592732
Blood potassium increased 67.50 15.50 72 28252 18464 42574547
Arrhythmia 65.31 15.50 105 28219 40212 42552799
General physical health deterioration 62.88 15.50 232 28092 151014 42441997
Electrocardiogram abnormal 61.01 15.50 52 28272 10093 42582918
Syncope 60.78 15.50 174 28150 99232 42493779
Myocardial ischaemia 57.74 15.50 65 28259 17697 42575314
Venous pressure jugular increased 57.47 15.50 21 28303 751 42592260
Drug interaction 57.07 15.50 337 27987 266662 42326349
Superinfection 56.55 15.50 31 28293 2920 42590091
Off label use 55.34 15.50 228 28096 638107 41954904
Cardiomyopathy 55.25 15.50 66 28258 19144 42573867
Left atrial enlargement 54.93 15.50 22 28302 1013 42591998
Labelled drug-drug interaction medication error 54.06 15.50 59 28265 15523 42577488
Hepatic vein dilatation 53.89 15.50 15 28309 216 42592795
Cardiomegaly 52.20 15.50 60 28264 16706 42576305
Hyperuricaemia 52.02 15.50 46 28278 9378 42583633
Gynaecomastia 51.48 15.50 52 28272 12515 42580496
Type V hyperlipidaemia 49.55 15.50 20 28304 940 42592071
Hyperthyroidism 49.23 15.50 54 28270 14287 42578724
Ventricular extrasystoles 48.73 15.50 52 28272 13338 42579673
Concomitant disease aggravated 48.53 15.50 38 28286 6548 42586463
Right ventricular dysfunction 48.39 15.50 22 28302 1387 42591624
Transplant failure 47.51 15.50 31 28293 4013 42588998
Cardiogenic shock 47.37 15.50 85 28239 35555 42557456
Dizziness 47.19 15.50 305 28019 248949 42344062
Blood creatinine increased 46.74 15.50 170 28154 109833 42483178
Blood thyroid stimulating hormone increased 46.67 15.50 34 28290 5258 42587753
Coronary artery stenosis 46.32 15.50 45 28279 10334 42582677
Electrolyte imbalance 46.32 15.50 57 28267 17044 42575967
Asthma-chronic obstructive pulmonary disease overlap syndrome 46.27 15.50 22 28302 1537 42591474
Blood pressure systolic decreased 46.17 15.50 33 28291 4954 42588057
Left ventricular dysfunction 46.04 15.50 47 28277 11454 42581557
Inferior vena cava dilatation 45.51 15.50 18 28306 802 42592209
Jugular vein distension 45.03 15.50 17 28307 667 42592344
Bronchial hyperreactivity 44.69 15.50 23 28301 1906 42591105
Drug ineffective 44.08 15.50 243 28081 629954 41963057
Orthopnoea 43.73 15.50 33 28291 5384 42587627
Respiratory tract haemorrhage 42.17 15.50 20 28304 1389 42591622
Immunosuppressant drug level increased 41.21 15.50 37 28287 7694 42585317
Product prescribing error 40.91 15.50 67 28257 26045 42566966
Ventricular hypokinesia 40.81 15.50 35 28289 6849 42586162
Platelet distribution width increased 40.07 15.50 11 28313 150 42592861
White blood cell count decreased 39.70 15.50 12 28312 110384 42482627
Atrial flutter 39.64 15.50 53 28271 17198 42575813
Angina pectoris 39.37 15.50 75 28249 32821 42560190
Cardiac failure congestive 38.66 15.50 135 28189 85467 42507544
Bundle branch block left 38.54 15.50 33 28291 6443 42586568
Seizure 38.42 15.50 16 28308 120545 42472466
Left ventricular enlargement 38.40 15.50 16 28308 816 42592195
Neutropenia 37.99 15.50 46 28278 199385 42393626
Left ventricular dilatation 37.09 15.50 16 28308 890 42592121
Chronic kidney disease 36.24 15.50 90 28234 47151 42545860
Waist circumference increased 35.82 15.50 16 28308 968 42592043
N-terminal prohormone brain natriuretic peptide abnormal 35.69 15.50 11 28313 230 42592781
Lung consolidation 35.67 15.50 32 28292 6645 42586366
Glomerular filtration rate abnormal 35.55 15.50 17 28307 1203 42591808
Rash 35.13 15.50 83 28241 276871 42316140
Pyrexia 35.10 15.50 139 28185 393903 42199108
Pulmonary function test abnormal 34.99 15.50 22 28302 2672 42590339
Micturition frequency decreased 34.84 15.50 12 28312 360 42592651
Intentional dose omission 34.66 15.50 36 28288 8950 42584061
Contraindicated product administered 34.51 15.50 61 28263 25211 42567800
Cellulitis gangrenous 34.02 15.50 11 28313 270 42592741
Glomerular filtration rate 33.62 15.50 9 28315 111 42592900
Inflammatory marker increased 33.40 15.50 31 28293 6725 42586286
Thrombocytopenia 33.05 15.50 47 28277 190232 42402779
Oesophageal carcinoma 32.40 15.50 36 28288 9660 42583351
Breath sounds abnormal 32.25 15.50 40 28284 12053 42580958
Malignant neoplasm progression 32.02 15.50 16 28308 108384 42484627
Mitral valve thickening 31.85 15.50 12 28312 468 42592543
Pulmonary arterial pressure increased 31.82 15.50 17 28307 1521 42591490
Pulmonary congestion 31.16 15.50 45 28279 15685 42577326
Venous pressure jugular decreased 31.07 15.50 7 28317 39 42592972
Atrial tachycardia 30.74 15.50 24 28300 4116 42588895
Ventricular dyskinesia 30.42 15.50 10 28314 259 42592752
Aortic valve incompetence 30.37 15.50 29 28295 6519 42586492
Sinus bradycardia 30.17 15.50 43 28281 14810 42578201
Arthralgia 29.77 15.50 57 28267 205181 42387830
Hypotonia 29.58 15.50 34 28290 9465 42583546
Atrial thrombosis 29.36 15.50 19 28305 2425 42590586
Cardiac ventricular thrombosis 29.13 15.50 17 28307 1805 42591206
Pulmonary oedema 27.58 15.50 88 28236 53184 42539827
Blood pressure inadequately controlled 26.60 15.50 19 28305 2849 42590162
Palpitations 26.38 15.50 84 28240 50713 42542298
Pleural effusion 26.32 15.50 131 28193 97035 42495976
Right ventricular failure 26.12 15.50 32 28292 9523 42583488
Circulatory collapse 25.98 15.50 52 28272 23584 42569427
Hypovolaemia 25.95 15.50 35 28289 11450 42581561
Brain natriuretic peptide increased 25.89 15.50 27 28297 6743 42586268
Neuropathy peripheral 25.89 15.50 18 28306 101835 42491176
Mitral valve calcification 25.16 15.50 11 28313 632 42592379
Heart rate irregular 24.89 15.50 41 28283 16009 42577002
Deep vein thrombosis 24.85 15.50 10 28314 76947 42516064
Rectal abscess 24.80 15.50 15 28309 1700 42591311
Neutrophil count decreased 24.47 15.50 6 28318 63409 42529602
Stenosis 24.42 15.50 16 28308 2085 42590926
Conduction disorder 24.09 15.50 17 28307 2501 42590510
Dehydration 24.07 15.50 169 28155 141598 42451413
Arterial intramural haematoma 23.74 15.50 6 28318 58 42592953
Leukopenia 23.67 15.50 10 28314 74736 42518275
Hypoglycaemia 23.31 15.50 90 28234 59764 42533247
Pyonephrosis 23.14 15.50 7 28317 137 42592874
Gastric dilatation 22.69 15.50 11 28313 802 42592209
Heart valve stenosis 22.49 15.50 6 28318 73 42592938
Renal failure 21.91 15.50 167 28157 143559 42449452
Pericardial fibrosis 21.64 15.50 7 28317 172 42592839
Pancytopenia 21.52 15.50 28 28296 117715 42475296
Infection 21.16 15.50 26 28298 112042 42480969
Hypertrophy 20.80 15.50 9 28315 504 42592507
Coma 20.79 15.50 5 28319 53549 42539462
No adverse event 20.69 15.50 65 28259 38956 42554055
Blood lactic acid 20.63 15.50 8 28316 338 42592673
Intentional product use issue 20.62 15.50 11 28313 71822 42521189
Lower respiratory tract infection 20.36 15.50 67 28257 41139 42551872
Pain 20.11 15.50 89 28235 244759 42348252
Depression 19.82 15.50 27 28297 111336 42481675
Hypervolaemia 19.82 15.50 46 28278 23079 42569932
Gastrointestinal stoma output decreased 19.67 15.50 6 28318 121 42592890
Ventricular fibrillation 19.63 15.50 54 28270 30069 42562942
Infusion related reaction 19.47 15.50 8 28316 60798 42532213
Oedema 19.28 15.50 77 28247 51924 42541087
Hypokinesia 19.20 15.50 28 28296 9843 42583168
Non-compaction cardiomyopathy 19.20 15.50 5 28319 55 42592956
Pain in extremity 19.17 15.50 45 28279 150559 42442452
Adrenocortical insufficiency acute 19.01 15.50 14 28310 2201 42590810
Genital swelling 18.98 15.50 7 28317 257 42592754
Vertigo 18.94 15.50 58 28266 34289 42558722
Varicose vein 18.41 15.50 12 28312 1550 42591461
Dyspnoea paroxysmal nocturnal 18.01 15.50 12 28312 1608 42591403
Constipation 17.97 15.50 52 28272 162239 42430772
Ascites 17.96 15.50 80 28244 56598 42536413
Encephalopathy 17.84 15.50 3 28321 41330 42551681
Renal atrophy 17.80 15.50 11 28313 1296 42591715
Heart transplant 17.62 15.50 10 28314 1007 42592004
Hypokalaemia 17.54 15.50 94 28230 71627 42521384
Glycosylated haemoglobin increased 17.39 15.50 31 28293 12893 42580118
Treatment failure 17.38 15.50 10 28314 62614 42530397
Hypersensitivity 16.84 15.50 14 28310 72356 42520655
Haemoglobin increased 16.83 15.50 19 28305 5187 42587824
Drug hypersensitivity 16.79 15.50 25 28299 99364 42493647
Ejection fraction 16.62 15.50 6 28318 207 42592804
Product use in unapproved indication 16.40 15.50 65 28259 184391 42408620
Brain natriuretic peptide abnormal 16.33 15.50 7 28317 383 42592628
Scrotal oedema 16.29 15.50 12 28312 1887 42591124
Weight increased 16.18 15.50 125 28199 107858 42485153
Ureteric haemorrhage 16.12 15.50 6 28318 226 42592785
Renal cyst 16.05 15.50 26 28298 10013 42582998
Aortic bruit 15.93 15.50 6 28318 234 42592777
Haemodynamic test abnormal 15.89 15.50 4 28320 38 42592973
Eosinophilia 15.81 15.50 53 28271 32846 42560165
Somnolence 15.78 15.50 45 28279 141060 42451951
Intracardiac thrombus 15.72 15.50 13 28311 2419 42590592
Cytokine release syndrome 15.71 15.50 5 28319 44522 42548489
Melaena 15.69 15.50 59 28265 38687 42554324
Crepitations 15.65 15.50 15 28309 3386 42589625
Sudden cardiac death 15.64 15.50 16 28308 3908 42589103
Stomatitis 15.51 15.50 7 28317 50322 42542689

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure 1086.54 15.57 687 32886 186939 110368787
Acute kidney injury 691.31 15.57 903 32670 634527 109921199
Cardiac failure chronic 628.49 15.57 213 33360 13598 110542128
Hyperkalaemia 465.06 15.57 361 33212 135435 110420291
Hypotension 388.56 15.57 622 32951 523227 110032499
Ventricular tachycardia 341.71 15.57 204 33369 49805 110505921
Oedema peripheral 279.22 15.57 416 33157 328244 110227482
Ejection fraction decreased 272.09 15.57 164 33409 40716 110515010
Atrial fibrillation 256.90 15.57 332 33241 229310 110326416
Rales 254.12 15.57 132 33441 24607 110531119
Dyspnoea 233.22 15.57 800 32773 1106072 109449654
Mitral valve incompetence 214.81 15.57 131 33442 33198 110522528
N-terminal prohormone brain natriuretic peptide increased 211.70 15.57 77 33496 6044 110549682
Glomerular filtration rate decreased 210.52 15.57 123 33450 28833 110526893
Bradycardia 196.37 15.57 239 33334 155278 110400448
Renal impairment 196.04 15.57 263 33310 188182 110367544
Drug interaction 193.15 15.57 451 33122 499732 110055994
Cardiac failure acute 176.94 15.57 103 33470 23975 110531751
Exercise tolerance decreased 146.17 15.57 72 33501 11995 110543731
Congestive cardiomyopathy 140.67 15.57 74 33499 14145 110541581
Ventricular arrhythmia 133.66 15.57 64 33509 10023 110545703
Dyspnoea at rest 132.46 15.57 60 33513 8286 110547440
Ischaemic cardiomyopathy 128.44 15.57 58 33515 7953 110547773
Ventricular enlargement 127.62 15.57 32 33541 692 110555034
Cardiomyopathy 127.49 15.57 95 33478 33430 110522296
Atrial enlargement 122.01 15.57 34 33539 1117 110554609
Dyspnoea exertional 121.76 15.57 154 33419 103906 110451820
Tricuspid valve incompetence 119.44 15.57 80 33493 23793 110531933
Blood pressure decreased 105.15 15.57 151 33422 114940 110440786
Oesophageal perforation 93.13 15.57 30 33543 1629 110554097
Blood creatinine increased 92.23 15.57 184 33389 182705 110373021
Soft tissue mass 91.31 15.57 29 33544 1504 110554222
Orthopnoea 91.31 15.57 51 33522 10970 110544756
Syncope 90.66 15.57 194 33379 202342 110353384
Computerised tomogram coronary artery abnormal 89.21 15.57 18 33555 136 110555590
Coronary artery stenosis 88.43 15.57 54 33519 13704 110542022
Cardiac amyloidosis 88.19 15.57 33 33540 2804 110552922
Multimorbidity 87.43 15.57 28 33545 1492 110554234
Infusion related reaction 86.51 15.57 8 33565 381154 110174572
Ventricular extrasystoles 83.50 15.57 63 33510 22578 110533148
Labelled drug-drug interaction medication error 83.36 15.57 70 33503 29232 110526494
Arrhythmia 81.42 15.57 103 33470 69472 110486254
Cardiogenic shock 80.34 15.57 93 33480 57245 110498481
Liver palpable 79.60 15.57 19 33554 332 110555394
Left ventricular dysfunction 79.25 15.57 62 33511 23431 110532295
Angina pectoris 78.96 15.57 96 33477 62199 110493527
Low cardiac output syndrome 78.81 15.57 24 33549 1082 110554644
Blood potassium increased 77.65 15.57 71 33502 33178 110522548
Joint swelling 76.53 15.57 20 33553 442825 110112901
Myocardial ischaemia 76.43 15.57 64 33509 26620 110529106
Ventricular hypokinesia 74.60 15.57 45 33528 11169 110544557
Rheumatoid arthritis 74.57 15.57 4 33569 299609 110256117
Cardiac failure congestive 73.82 15.57 150 33423 150850 110404876
Cardiomegaly 73.55 15.57 65 33508 29065 110526661
Hyponatraemia 72.79 15.57 186 33387 217467 110338259
Renal phospholipidosis 72.19 15.57 18 33555 380 110555346
Pain 70.91 15.57 113 33460 954842 109600884
Renal failure 70.03 15.57 188 33385 226386 110329340
Arthralgia 69.19 15.57 81 33492 779551 109776175
Left ventricular dilatation 68.88 15.57 23 33550 1399 110554327
Electrocardiogram abnormal 68.86 15.57 52 33521 18657 110537069
Hyperuricaemia 68.64 15.57 47 33526 14484 110541242
Product prescribing error 64.88 15.57 79 33494 51252 110504474
Hepatic vein dilatation 64.74 15.57 15 33558 229 110555497
Gynaecomastia 62.92 15.57 38 33535 9452 110546274
Pulmonary congestion 62.52 15.57 61 33512 30905 110524821
Hypovolaemia 62.11 15.57 52 33521 21622 110534104
Venous pressure jugular increased 62.05 15.57 21 33552 1331 110554395
Pleural effusion 61.63 15.57 154 33419 177555 110378171
Completed suicide 61.06 15.57 3 33570 242378 110313348
Left atrial enlargement 60.69 15.57 22 33551 1709 110554017
Arthropathy 60.26 15.57 8 33565 287514 110268212
Hyperthyroidism 59.74 15.57 58 33515 29203 110526523
Dehydration 59.13 15.57 203 33370 279308 110276418
Alopecia 58.37 15.57 19 33554 364734 110190992
Hypersensitivity 58.03 15.57 25 33548 403973 110151753
Immunosuppressant drug level increased 57.95 15.57 39 33534 11685 110544041
Transplant failure 57.65 15.57 30 33543 5605 110550121
Respiratory tract haemorrhage 57.45 15.57 22 33551 1992 110553734
Superinfection 57.02 15.57 30 33543 5733 110549993
Chronic kidney disease 56.75 15.57 91 33482 76200 110479526
Rash 56.43 15.57 102 33471 820862 109734864
Drug hypersensitivity 56.42 15.57 34 33539 454056 110101670
Inferior vena cava dilatation 56.39 15.57 18 33555 949 110554777
Hepatic enzyme increased 56.36 15.57 14 33559 320878 110234848
Type V hyperlipidaemia 56.34 15.57 20 33553 1462 110554264
Stenosis 56.07 15.57 25 33548 3326 110552400
Febrile neutropenia 55.29 15.57 14 33559 316753 110238973
Electrolyte imbalance 55.15 15.57 62 33511 36966 110518760
Concomitant disease aggravated 54.79 15.57 43 33530 16321 110539405
Bronchial hyperreactivity 54.73 15.57 25 33548 3519 110552207
Pulmonary arterial pressure increased 54.48 15.57 28 33545 5099 110550627
Pulmonary oedema 54.01 15.57 104 33469 100555 110455171
Blood thyroid stimulating hormone increased 53.91 15.57 38 33535 12263 110543463
Atrial flutter 53.15 15.57 50 33523 24212 110531514
Pericarditis 51.33 15.57 4 33569 219110 110336616
Dizziness 51.31 15.57 375 33198 697818 109857908
Stomatitis 51.07 15.57 10 33563 270232 110285494
N-terminal prohormone brain natriuretic peptide abnormal 50.63 15.57 13 33560 310 110555416
Left ventricular enlargement 49.91 15.57 16 33557 855 110554871
Oesophageal carcinoma 49.12 15.57 35 33538 11489 110544237
Treatment failure 48.87 15.57 12 33561 277222 110278504
Blood pressure systolic decreased 48.67 15.57 37 33536 13404 110542322
Platelet distribution width increased 48.56 15.57 11 33562 151 110555575
Melaena 47.07 15.57 79 33494 68678 110487048
Atrial thrombosis 46.95 15.57 24 33549 4322 110551404
Sinusitis 46.50 15.57 16 33557 296672 110259054
Brain natriuretic peptide increased 45.39 15.57 33 33540 11176 110544550
Hypocalcaemia 44.61 15.57 75 33498 65291 110490435
General physical health deterioration 43.86 15.57 249 33324 425046 110130680
Pulmonary function test abnormal 43.78 15.57 24 33549 4976 110550750
Right ventricular dysfunction 43.77 15.57 21 33552 3302 110552424
Coronary artery occlusion 43.46 15.57 37 33536 15735 110539991
Headache 43.45 15.57 131 33442 882246 109673480
Lung consolidation 42.78 15.57 31 33542 10445 110545281
Aortic valve incompetence 41.47 15.57 31 33542 10950 110544776
Musculoskeletal stiffness 40.67 15.57 17 33556 279805 110275921
Hypoglycaemia 40.64 15.57 101 33472 116003 110439723
Glomerular filtration rate abnormal 40.58 15.57 18 33555 2365 110553361
Abdominal discomfort 40.46 15.57 36 33537 393822 110161904
Jugular vein distension 40.25 15.57 16 33557 1600 110554126
Eosinophilia 40.23 15.57 67 33506 57869 110497857
Infection 39.80 15.57 31 33542 362169 110193557
Nasopharyngitis 39.38 15.57 37 33536 394324 110161402
Breath sounds abnormal 38.62 15.57 43 33530 25361 110530365
Waist circumference increased 38.57 15.57 16 33557 1785 110553941
Asthma-chronic obstructive pulmonary disease overlap syndrome 38.48 15.57 24 33549 6320 110549406
Osteoarthritis 38.45 15.57 5 33568 182618 110373108
Drug intolerance 38.45 15.57 40 33533 406472 110149254
Hypokalaemia 38.11 15.57 132 33441 182316 110373410
Cellulitis gangrenous 38.01 15.57 11 33562 415 110555311
Migraine 37.88 15.57 4 33569 171648 110384078
Psoriatic arthropathy 37.77 15.57 7 33566 196754 110358972
Bundle branch block left 37.09 15.57 31 33542 12857 110542869
Abdominal pain upper 36.96 15.57 31 33542 349080 110206646
Vascular stent thrombosis 36.51 15.57 20 33553 4141 110551585
Off label use 36.33 15.57 287 33286 1499898 109055828
Glomerular filtration rate 36.28 15.57 9 33564 186 110555540
Cardiac ventricular disorder 35.53 15.57 10 33563 341 110555385
Urticaria 35.40 15.57 27 33546 318830 110236896
Degenerative aortic valve disease 34.96 15.57 9 33564 217 110555509
Wheezing 34.75 15.57 17 33556 255213 110300513
Drug abuse 34.73 15.57 6 33567 177405 110378321
Right ventricular failure 34.52 15.57 41 33532 25913 110529813
Hypomagnesaemia 34.39 15.57 64 33509 60306 110495420
Inflammatory marker increased 33.98 15.57 31 33542 14438 110541288
Gastrointestinal haemorrhage 33.91 15.57 119 33454 165399 110390327
Tachypnoea 33.51 15.57 50 33523 39345 110516381
Intentional product use issue 33.02 15.57 17 33556 247889 110307837
Pain in extremity 32.98 15.57 61 33512 487057 110068669
Cardiac ventricular thrombosis 32.90 15.57 17 33556 3130 110552596
Ventricular dyskinesia 32.88 15.57 10 33563 449 110555277
Ascites 32.75 15.57 81 33492 92727 110462999
Acute myocardial infarction 32.67 15.57 76 33497 83701 110472025
Micturition frequency decreased 32.28 15.57 12 33561 1001 110554725
Polyuria 32.22 15.57 33 33540 17705 110538021
Anaemia 32.00 15.57 279 33294 546807 110008919
Mitral valve thickening 31.61 15.57 11 33562 758 110554968
Circulatory collapse 31.58 15.57 51 33522 42942 110512784
Venous pressure jugular decreased 31.47 15.57 7 33566 88 110555638
Wound 31.34 15.57 16 33557 234421 110321305
Subdural haematoma 30.62 15.57 46 33527 36408 110519318
Intentional dose omission 30.55 15.57 34 33539 20046 110535680
Left ventricular hypertrophy 30.37 15.57 28 33545 13216 110542510
Ventricular fibrillation 30.34 15.57 49 33524 41264 110514462
Impaired healing 30.15 15.57 11 33562 196706 110359020
Folliculitis 30.04 15.57 7 33566 167646 110388080
Liver injury 29.63 15.57 5 33568 150408 110405318
Rectal abscess 29.45 15.57 15 33558 2681 110553045
Conduction disorder 28.87 15.57 17 33556 4038 110551688
Subclavian vein thrombosis 28.75 15.57 15 33558 2817 110552909
Supraventricular extrasystoles 28.74 15.57 22 33551 8051 110547675
Drug ineffective 28.53 15.57 310 33263 1520230 109035496
Heart rate irregular 28.43 15.57 43 33530 34231 110521495
Hypotonia 28.07 15.57 29 33544 15716 110540010
Therapeutic drug monitoring analysis not performed 27.88 15.57 13 33560 1918 110553808
Femoral neck fracture 27.72 15.57 26 33547 12541 110543185
Hypervolaemia 27.63 15.57 52 33521 49408 110506318
BRASH syndrome 27.54 15.57 16 33557 3707 110552019
Ill-defined disorder 27.22 15.57 7 33566 156846 110398880
Dyspepsia 27.10 15.57 12 33561 190953 110364773
Epistaxis 26.93 15.57 94 33479 130278 110425448
Blister 26.87 15.57 18 33555 227358 110328368
Discomfort 26.74 15.57 16 33557 214691 110341035
Cardiovascular insufficiency 26.65 15.57 15 33558 3273 110552453
Pyonephrosis 26.54 15.57 7 33566 186 110555540
Helicobacter infection 26.50 15.57 11 33562 181866 110373860
Joint range of motion decreased 26.47 15.57 3 33570 121829 110433897
Wound haemorrhage 26.43 15.57 17 33556 4721 110551005
Scrotal oedema 26.40 15.57 12 33561 1669 110554057
Gout 26.35 15.57 43 33530 36523 110519203
Benign prostatic hyperplasia 26.25 15.57 30 33543 18204 110537522
Dry mouth 26.20 15.57 14 33559 199934 110355792
Mitral valve calcification 26.09 15.57 12 33561 1716 110554010
Product use issue 25.88 15.57 34 33539 311661 110244065
Pericardial fibrosis 25.09 15.57 7 33566 231 110555495
Pyrexia 24.97 15.57 165 33408 898100 109657626
Gastrointestinal disorder 24.97 15.57 22 33551 241930 110313796
Sinus bradycardia 24.47 15.57 37 33536 29446 110526280
Cardiac disorder 24.24 15.57 64 33509 76216 110479510
Blood lactic acid 24.22 15.57 8 33565 470 110555256
Mobility decreased 24.01 15.57 22 33551 237400 110318326
Injection site pain 23.99 15.57 12 33561 177910 110377816
Back pain 23.75 15.57 48 33525 370948 110184778
Hypokinesia 23.47 15.57 31 33542 21795 110533931
Hydrothorax 23.43 15.57 11 33562 1647 110554079
Fall 23.41 15.57 283 33290 603199 109952527
Maternal exposure during pregnancy 23.06 15.57 26 33547 254857 110300869
Non-compaction cardiomyopathy 22.77 15.57 5 33568 59 110555667
Hypertrophy 22.39 15.57 9 33564 926 110554800
White blood cell count decreased 22.32 15.57 22 33551 229368 110326358
Morganella infection 22.15 15.57 10 33563 1369 110554357
Heart valve stenosis 22.08 15.57 6 33567 179 110555547
Rash scarlatiniform 22.08 15.57 7 33566 361 110555365
Therapeutic product effect decreased 22.02 15.57 25 33548 244291 110311435
Inflammation 21.90 15.57 16 33557 193222 110362504
Dyspnoea paroxysmal nocturnal 21.88 15.57 12 33561 2490 110553236
Seizure 21.77 15.57 21 33552 221164 110334562
Hypoaldosteronism 21.59 15.57 8 33565 661 110555065
Blood cholesterol increased 21.34 15.57 15 33558 184770 110370956
Gastric dilatation 21.06 15.57 11 33562 2070 110553656
Injury 20.99 15.57 14 33559 177251 110378475
Coma 20.96 15.57 5 33568 117864 110437862
Genital swelling 20.93 15.57 7 33566 428 110555298
No adverse event 20.53 15.57 59 33514 73780 110481946
Blood urea increased 20.49 15.57 49 33524 54908 110500818
Palpitations 20.35 15.57 99 33474 159113 110396613
Penile pain 20.34 15.57 9 33564 1175 110554551
Thrombotic cerebral infarction 20.26 15.57 8 33565 786 110554940
Exposure during pregnancy 20.12 15.57 13 33560 167411 110388315
Arterial intramural haematoma 20.11 15.57 6 33567 252 110555474
Gastrointestinal stoma output decreased 19.93 15.57 6 33567 260 110555466
Cardiac aneurysm 19.91 15.57 10 33563 1735 110553991
Aortic bruit 19.84 15.57 6 33567 264 110555462
Contusion 19.84 15.57 25 33548 233336 110322390
Renal atrophy 19.82 15.57 11 33562 2335 110553391
Acute pulmonary oedema 19.62 15.57 25 33548 16971 110538755
Electrocardiogram QT prolonged 19.50 15.57 75 33498 108885 110446841
Orthostatic hypotension 19.46 15.57 54 33519 66195 110489531
Haematochezia 19.45 15.57 78 33495 115446 110440280
Peripheral artery haematoma 19.40 15.57 5 33568 121 110555605
Product administration error 19.40 15.57 38 33535 37179 110518547
Sudden cardiac death 19.28 15.57 15 33558 5622 110550104
Glomerular filtration rate increased 18.89 15.57 10 33563 1935 110553791
Myelosuppression 18.88 15.57 3 33570 94337 110461389
Neuropathy peripheral 18.86 15.57 16 33557 179261 110376465
Injection site erythema 18.84 15.57 3 33570 94173 110461553
Adverse event 18.60 15.57 5 33568 108804 110446922
Dermo-hypodermitis 18.38 15.57 9 33564 1479 110554247
Sciatica 18.35 15.57 3 33570 92396 110463330
Blood cyanide increased 18.23 15.57 4 33569 47 110555679
Neutropenia 18.10 15.57 56 33517 374564 110181162
Psoriasis 18.05 15.57 10 33563 139983 110415743
Swelling 18.03 15.57 51 33522 350990 110204736
Limited symptom panic attack 18.01 15.57 4 33569 50 110555676
Heart rate abnormal 17.97 15.57 16 33557 7222 110548504
Haemoptysis 17.93 15.57 55 33518 71299 110484427
Peripheral coldness 17.91 15.57 25 33548 18515 110537211
Depression 17.90 15.57 44 33529 317291 110238435
Adrenocortical insufficiency acute 17.81 15.57 13 33560 4427 110551299
Amnesia 17.73 15.57 5 33568 105403 110450323
Akinesia 17.65 15.57 12 33561 3655 110552071
Heart transplant 17.61 15.57 9 33564 1619 110554107
Therapeutic drug monitoring analysis incorrectly performed 17.56 15.57 7 33566 705 110555021
Glycosylated haemoglobin increased 17.32 15.57 28 33545 23591 110532135
Pulmonary hypertension 17.21 15.57 46 33527 55174 110500552
Anxiety 17.09 15.57 51 33522 345027 110210699
Tachyphylaxis 17.03 15.57 6 33567 429 110555297
Ocular myasthenia 16.96 15.57 7 33566 771 110554955
Sinus node dysfunction 16.74 15.57 17 33556 9030 110546696
Pemphigoid 16.74 15.57 25 33548 19682 110536044
Blood potassium abnormal 16.69 15.57 12 33561 3993 110551733
Blood bilirubin unconjugated decreased 16.59 15.57 4 33569 73 110555653
Haemoglobin increased 16.58 15.57 17 33556 9130 110546596
Atrial tachycardia 16.53 15.57 17 33556 9161 110546565
Loss of personal independence in daily activities 16.26 15.57 13 33560 150007 110405719
Constipation 16.23 15.57 55 33518 357731 110197995
Drug level increased 16.15 15.57 41 33532 47678 110508048
Cold sweat 16.00 15.57 26 33547 22005 110533721
Cardiac dysfunction 15.93 15.57 14 33559 6209 110549517
Brain natriuretic peptide abnormal 15.92 15.57 7 33566 901 110554825
Crepitations 15.89 15.57 18 33555 10817 110544909
Cardiac resynchronisation therapy 15.64 15.57 4 33569 94 110555632
Left atrial dilatation 15.61 15.57 11 33562 3549 110552177
Myocardial necrosis 15.61 15.57 6 33567 549 110555177

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03DA04 CARDIOVASCULAR SYSTEM
DIURETICS
ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
Aldosterone antagonists
ATC C03DA54 CARDIOVASCULAR SYSTEM
DIURETICS
ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
Aldosterone antagonists
FDA MoA N0000011310 Aldosterone Antagonists
FDA EPC N0000175557 Aldosterone Antagonist
MeSH PA D000451 Mineralocorticoid Receptor Antagonists
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D006727 Hormone Antagonists
MeSH PA D045283 Natriuretic Agents
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:50844 aldosterone antagonist

Related Drugs by ATC class:

C03DA Aldosterone antagonists 5 drugs
canrenonedapagliflozinfinerenonepotassium canrenoatespironolactone

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic Heart Failure Following Myocardial Infarction indication
Hyperkalemia contraindication 14140009
Diabetic renal disease contraindication 127013003
Impaired renal function disorder contraindication 197663003
Disease of liver contraindication 235856003 DOID:409




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Mineralocorticoid receptor Nuclear hormone receptor ANTAGONIST IC50 7 WOMBAT-PK CHEMBL
Glucocorticoid receptor Nuclear hormone receptor IC50 4.74 CHEMBL
Androgen receptor Nuclear hormone receptor IC50 4.77 CHEMBL
Progesterone receptor Nuclear hormone receptor Ki 4.70 CHEMBL
Mineralocorticoid receptor Transcription factor IC50 7.40 CHEMBL

External reference:

IDSource
4021363 VUID
N0000148782 NUI
D01115 KEGG_DRUG
4021363 VANDF
C0961485 UMLSCUI
CHEBI:31547 CHEBI
YNU PDB_CHEM_ID
CHEMBL1095097 ChEMBL_ID
D000077545 MESH_DESCRIPTOR_UI
DB00700 DRUGBANK_ID
443872 PUBCHEM_CID
2876 IUPHAR_LIGAND_ID
C058465 MESH_SUPPLEMENTAL_RECORD_UI
7596 INN_ID
6995V82D0B UNII
298869 RXNORM
147386 MMSL
16969 MMSL
d04815 MMSL
009774 NDDF
398699008 SNOMEDCT_US
407010008 SNOMEDCT_US
6995V82D0B INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Eplerenone Human Prescription Drug Label 1 16571-173 TABLET 25 mg ORAL ANDA 26 sections
Eplerenone Human Prescription Drug Label 1 16571-174 TABLET 50 mg ORAL ANDA 26 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 16729-293 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 16729-293 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 16729-294 TABLET, FILM COATED 50 mg ORAL ANDA 26 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 16729-294 TABLET, FILM COATED 50 mg ORAL ANDA 26 sections
Inspra HUMAN PRESCRIPTION DRUG LABEL 1 21695-797 TABLET 25 mg ORAL NDA 27 sections
EPLERENONE HUMAN PRESCRIPTION DRUG LABEL 1 31722-049 TABLET, FILM COATED 25 mg ORAL ANDA 23 sections
EPLERENONE HUMAN PRESCRIPTION DRUG LABEL 1 31722-050 TABLET, FILM COATED 50 mg ORAL ANDA 23 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 42254-011 TABLET 50 mg ORAL ANDA 23 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 42291-454 TABLET, COATED 25 mg ORAL ANDA 29 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 42291-455 TABLET, COATED 50 mg ORAL ANDA 29 sections
EPLERENONE HUMAN PRESCRIPTION DRUG LABEL 1 51991-877 TABLET, FILM COATED 25 mg ORAL ANDA 29 sections
EPLERENONE HUMAN PRESCRIPTION DRUG LABEL 1 51991-878 TABLET, FILM COATED 50 mg ORAL ANDA 29 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 54868-6065 TABLET 25 mg ORAL ANDA 23 sections
Inspra HUMAN PRESCRIPTION DRUG LABEL 1 58151-142 TABLET, FILM COATED 25 mg ORAL NDA 29 sections
Inspra HUMAN PRESCRIPTION DRUG LABEL 1 58151-143 TABLET, FILM COATED 50 mg ORAL NDA 29 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 59762-1107 TABLET, FILM COATED 25 mg ORAL NDA authorized generic 29 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 59762-1107 TABLET, FILM COATED 25 mg ORAL NDA authorized generic 29 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 59762-1108 TABLET, FILM COATED 50 mg ORAL NDA authorized generic 29 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 59762-1108 TABLET, FILM COATED 50 mg ORAL NDA authorized generic 29 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 59762-1710 TABLET, FILM COATED 25 mg ORAL NDA authorized generic 27 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 59762-1710 TABLET, FILM COATED 25 mg ORAL NDA authorized generic 27 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 59762-1720 TABLET, FILM COATED 50 mg ORAL NDA authorized generic 27 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 59762-1720 TABLET, FILM COATED 50 mg ORAL NDA authorized generic 27 sections
EPLERENONE HUMAN PRESCRIPTION DRUG LABEL 1 60687-451 TABLET, FILM COATED 25 mg ORAL ANDA 27 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 63629-9414 TABLET, FILM COATED 25 mg ORAL ANDA 25 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 69367-307 TABLET, COATED 25 mg ORAL ANDA 29 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 69367-308 TABLET, COATED 50 mg ORAL ANDA 29 sections
Eplerenone HUMAN PRESCRIPTION DRUG LABEL 1 71205-863 TABLET, COATED 25 mg ORAL ANDA 27 sections