Stem definition | Drug id | CAS RN |
---|---|---|
sympathomimetic, phenethyl derivatives | 1028 | 51-43-4 |
Dose | Unit | Route |
---|---|---|
0.50 | mg | P |
2.24 | mg | Inhal.aerosol |
20 | mg | Inhal.solution |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.09 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 19, 1948 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sinusitis | 721.57 | 9.86 | 1271 | 102648 | 169287 | 50331918 |
Hereditary angioedema | 563.40 | 9.86 | 258 | 103661 | 5184 | 50496021 |
Stress cardiomyopathy | 418.06 | 9.86 | 238 | 103681 | 7649 | 50493556 |
Device failure | 368.18 | 9.86 | 194 | 103725 | 5334 | 50495871 |
Anaphylactic reaction | 350.76 | 9.86 | 491 | 103428 | 53564 | 50447641 |
Local anaesthetic systemic toxicity | 343.35 | 9.86 | 101 | 103818 | 511 | 50500694 |
Toxic anterior segment syndrome | 321.31 | 9.86 | 121 | 103798 | 1444 | 50499761 |
Anaesthetic complication | 309.52 | 9.86 | 121 | 103798 | 1609 | 50499596 |
Infusion site swelling | 263.04 | 9.86 | 171 | 103748 | 7005 | 50494200 |
Infusion site pain | 240.66 | 9.86 | 201 | 103718 | 12145 | 50489060 |
Contraindicated product administered | 240.16 | 9.86 | 17 | 103902 | 148941 | 50352264 |
Infusion site erythema | 235.02 | 9.86 | 172 | 103747 | 8555 | 50492650 |
Accidental exposure to product | 232.09 | 9.86 | 261 | 103658 | 22796 | 50478409 |
Cardiac arrest | 221.69 | 9.86 | 514 | 103405 | 83137 | 50418068 |
Drug intolerance | 218.97 | 9.86 | 88 | 103831 | 219016 | 50282189 |
Pemphigus | 218.74 | 9.86 | 6 | 103913 | 120160 | 50381045 |
Joint swelling | 194.26 | 9.86 | 133 | 103786 | 245153 | 50256052 |
Anaphylactic shock | 187.41 | 9.86 | 219 | 103700 | 19936 | 50481269 |
Bronchitis | 181.99 | 9.86 | 548 | 103371 | 103611 | 50397594 |
Hand deformity | 178.74 | 9.86 | 6 | 103913 | 100193 | 50401012 |
Infusion site extravasation | 177.76 | 9.86 | 133 | 103786 | 6843 | 50494362 |
Systemic lupus erythematosus | 176.05 | 9.86 | 37 | 103882 | 140585 | 50360620 |
Upper respiratory tract infection | 172.45 | 9.86 | 403 | 103516 | 65495 | 50435710 |
Glossodynia | 170.58 | 9.86 | 19 | 103900 | 115550 | 50385655 |
Pulseless electrical activity | 155.81 | 9.86 | 122 | 103797 | 6719 | 50494486 |
Infusion site pruritus | 154.63 | 9.86 | 98 | 103821 | 3839 | 50497366 |
Synovitis | 154.20 | 9.86 | 33 | 103886 | 123832 | 50377373 |
Chondrolysis | 146.57 | 9.86 | 41 | 103878 | 167 | 50501038 |
Alopecia | 144.95 | 9.86 | 174 | 103745 | 244873 | 50256332 |
Completed suicide | 143.53 | 9.86 | 46 | 103873 | 131843 | 50369362 |
Lagophthalmos | 132.56 | 9.86 | 41 | 103878 | 253 | 50500952 |
Hepatic enzyme increased | 129.47 | 9.86 | 60 | 103859 | 137320 | 50363885 |
Rheumatoid arthritis | 129.41 | 9.86 | 135 | 103784 | 202415 | 50298790 |
Bradycardia | 124.99 | 9.86 | 352 | 103567 | 64074 | 50437131 |
Arthropathy | 117.89 | 9.86 | 91 | 103828 | 157815 | 50343390 |
Ear infection | 117.80 | 9.86 | 200 | 103719 | 25770 | 50475435 |
Kounis syndrome | 113.17 | 9.86 | 53 | 103866 | 1122 | 50500083 |
Abdominal discomfort | 112.63 | 9.86 | 189 | 103730 | 231452 | 50269753 |
Incorrect route of product administration | 111.35 | 9.86 | 163 | 103756 | 18503 | 50482702 |
Administration site swelling | 109.49 | 9.86 | 50 | 103869 | 997 | 50500208 |
Urticaria | 109.37 | 9.86 | 541 | 103378 | 129020 | 50372185 |
Pericarditis | 108.69 | 9.86 | 16 | 103903 | 78673 | 50422532 |
Headache | 108.07 | 9.86 | 1546 | 102373 | 504989 | 49996216 |
Wound | 108.03 | 9.86 | 41 | 103878 | 105753 | 50395452 |
Infusion site bruising | 107.68 | 9.86 | 64 | 103855 | 2231 | 50498974 |
Ventricular tachycardia | 107.45 | 9.86 | 147 | 103772 | 15674 | 50485531 |
Hypotension | 103.11 | 9.86 | 831 | 103088 | 234638 | 50266567 |
Corneal oedema | 101.90 | 9.86 | 52 | 103867 | 1335 | 50499870 |
Therapeutic product effect decreased | 100.79 | 9.86 | 79 | 103840 | 135971 | 50365234 |
Product quality issue | 97.97 | 9.86 | 204 | 103715 | 30654 | 50470551 |
Infusion site nodule | 96.84 | 9.86 | 47 | 103872 | 1080 | 50500125 |
General physical health deterioration | 95.44 | 9.86 | 91 | 103828 | 142343 | 50358862 |
Infusion site haemorrhage | 89.57 | 9.86 | 63 | 103856 | 2941 | 50498264 |
Fear | 86.71 | 9.86 | 127 | 103792 | 14422 | 50486783 |
Arthralgia | 86.70 | 9.86 | 537 | 103382 | 438165 | 50063040 |
Treatment failure | 79.95 | 9.86 | 99 | 103820 | 137538 | 50363667 |
Respiratory tract infection | 79.59 | 9.86 | 192 | 103727 | 31825 | 50469380 |
Anhedonia | 79.52 | 9.86 | 98 | 103821 | 9426 | 50491779 |
Helicobacter infection | 79.11 | 9.86 | 6 | 103913 | 49696 | 50451509 |
Renal injury | 79.09 | 9.86 | 93 | 103826 | 8518 | 50492687 |
COVID-19 | 78.13 | 9.86 | 242 | 103677 | 46420 | 50454785 |
Bronchospasm | 77.66 | 9.86 | 122 | 103797 | 14732 | 50486473 |
Left ventricle outflow tract obstruction | 77.18 | 9.86 | 26 | 103893 | 218 | 50500987 |
Administration site pain | 76.53 | 9.86 | 34 | 103885 | 634 | 50500571 |
Injection site ischaemia | 75.13 | 9.86 | 15 | 103904 | 3 | 50501202 |
Ventricular fibrillation | 73.05 | 9.86 | 99 | 103820 | 10460 | 50490745 |
Shock | 72.07 | 9.86 | 142 | 103777 | 20508 | 50480697 |
Cardiogenic shock | 71.88 | 9.86 | 121 | 103798 | 15478 | 50485727 |
Incorrect drug administration rate | 71.60 | 9.86 | 52 | 103867 | 2554 | 50498651 |
Asthma | 71.09 | 9.86 | 367 | 103552 | 88970 | 50412235 |
Stridor | 71.05 | 9.86 | 56 | 103863 | 3113 | 50498092 |
Unevaluable event | 70.82 | 9.86 | 232 | 103687 | 45834 | 50455371 |
Methaemoglobinaemia | 70.79 | 9.86 | 47 | 103872 | 1995 | 50499210 |
Maternal exposure during delivery | 68.96 | 9.86 | 36 | 103883 | 970 | 50500235 |
Infusion site mass | 68.67 | 9.86 | 38 | 103881 | 1154 | 50500051 |
Expired product administered | 66.62 | 9.86 | 68 | 103851 | 5314 | 50495891 |
Injection site pallor | 66.61 | 9.86 | 17 | 103902 | 44 | 50501161 |
Electrocardiogram ST segment elevation | 66.55 | 9.86 | 56 | 103863 | 3417 | 50497788 |
Cauda equina syndrome | 66.47 | 9.86 | 32 | 103887 | 722 | 50500483 |
Endophthalmitis | 66.40 | 9.86 | 52 | 103867 | 2864 | 50498341 |
Injury associated with device | 65.45 | 9.86 | 53 | 103866 | 3064 | 50498141 |
Tachycardia | 64.19 | 9.86 | 387 | 103532 | 99376 | 50401829 |
Administration site erythema | 63.77 | 9.86 | 28 | 103891 | 507 | 50500698 |
Pulse absent | 61.82 | 9.86 | 62 | 103857 | 4744 | 50496461 |
Arteriospasm coronary | 61.39 | 9.86 | 53 | 103866 | 3349 | 50497856 |
Airway peak pressure increased | 57.64 | 9.86 | 22 | 103897 | 273 | 50500932 |
Peripheral ischaemia | 56.55 | 9.86 | 56 | 103863 | 4220 | 50496985 |
Folliculitis | 56.48 | 9.86 | 7 | 103912 | 39218 | 50461987 |
Muscle injury | 54.98 | 9.86 | 6 | 103913 | 37105 | 50464100 |
Infusion site urticaria | 54.95 | 9.86 | 31 | 103888 | 978 | 50500227 |
Hypopyon | 54.79 | 9.86 | 27 | 103892 | 642 | 50500563 |
Diarrhoea | 54.13 | 9.86 | 867 | 103052 | 587609 | 49913596 |
Hyponatraemia | 53.89 | 9.86 | 71 | 103848 | 96068 | 50405137 |
Migraine | 53.59 | 9.86 | 300 | 103619 | 74980 | 50426225 |
Injury | 52.19 | 9.86 | 219 | 103700 | 48706 | 50452499 |
Impaired healing | 51.05 | 9.86 | 41 | 103878 | 69745 | 50431460 |
Neutropenia | 50.96 | 9.86 | 146 | 103773 | 147819 | 50353386 |
Confusional state | 50.73 | 9.86 | 203 | 103716 | 185725 | 50315480 |
Cataract operation complication | 50.63 | 9.86 | 16 | 103903 | 107 | 50501098 |
Generalised tonic-clonic seizure | 50.25 | 9.86 | 143 | 103776 | 26167 | 50475038 |
Emotional distress | 50.16 | 9.86 | 151 | 103768 | 28512 | 50472693 |
Extradural abscess | 50.10 | 9.86 | 27 | 103892 | 777 | 50500428 |
Electrocardiogram ST segment depression | 49.69 | 9.86 | 42 | 103877 | 2578 | 50498627 |
Body tinea | 49.55 | 9.86 | 32 | 103887 | 1295 | 50499910 |
Infusion site rash | 49.22 | 9.86 | 32 | 103887 | 1310 | 50499895 |
Haemodynamic instability | 49.20 | 9.86 | 71 | 103848 | 7953 | 50493252 |
Tryptase increased | 48.31 | 9.86 | 18 | 103901 | 208 | 50500997 |
Acute kidney injury | 48.17 | 9.86 | 273 | 103646 | 227785 | 50273420 |
Lip swelling | 47.79 | 9.86 | 135 | 103784 | 24601 | 50476604 |
Impaired quality of life | 46.87 | 9.86 | 60 | 103859 | 5996 | 50495209 |
Staphylococcal infection | 45.73 | 9.86 | 169 | 103750 | 35447 | 50465758 |
Discomfort | 44.25 | 9.86 | 98 | 103821 | 108282 | 50392923 |
Pharyngeal oedema | 44.10 | 9.86 | 89 | 103830 | 13076 | 50488129 |
Needle issue | 44.06 | 9.86 | 64 | 103855 | 7211 | 50493994 |
Illness | 43.62 | 9.86 | 130 | 103789 | 24410 | 50476795 |
Ventricular hypokinesia | 43.40 | 9.86 | 47 | 103872 | 3933 | 50497272 |
Infusion site reaction | 43.16 | 9.86 | 36 | 103883 | 2170 | 50499035 |
Musculoskeletal stiffness | 42.62 | 9.86 | 129 | 103790 | 128352 | 50372853 |
Liquid product physical issue | 42.49 | 9.86 | 24 | 103895 | 759 | 50500446 |
Pulmonary oedema | 42.41 | 9.86 | 206 | 103713 | 48732 | 50452473 |
Infusion site irritation | 41.80 | 9.86 | 22 | 103897 | 603 | 50500602 |
Lower respiratory tract infection | 41.45 | 9.86 | 83 | 103836 | 95118 | 50406087 |
Anaemia | 40.91 | 9.86 | 327 | 103592 | 252129 | 50249076 |
COVID-19 immunisation | 40.84 | 9.86 | 23 | 103896 | 723 | 50500482 |
Decreased appetite | 40.04 | 9.86 | 245 | 103674 | 200678 | 50300527 |
Extradural haematoma | 39.86 | 9.86 | 30 | 103889 | 1557 | 50499648 |
Wrong product administered | 39.76 | 9.86 | 52 | 103867 | 5308 | 50495897 |
Abortion spontaneous | 39.70 | 9.86 | 18 | 103901 | 41754 | 50459451 |
Angioedema | 39.67 | 9.86 | 168 | 103751 | 37508 | 50463697 |
Post procedural complication | 39.06 | 9.86 | 92 | 103827 | 15012 | 50486193 |
Seizure | 37.71 | 9.86 | 389 | 103530 | 117485 | 50383720 |
C-reactive protein increased | 37.34 | 9.86 | 49 | 103870 | 66425 | 50434780 |
Procedural hypotension | 37.32 | 9.86 | 25 | 103894 | 1077 | 50500128 |
Vitritis | 37.27 | 9.86 | 23 | 103896 | 859 | 50500346 |
Product use issue | 37.19 | 9.86 | 169 | 103750 | 149306 | 50351899 |
Blood creatinine increased | 37.07 | 9.86 | 62 | 103857 | 76098 | 50425107 |
Troponin I increased | 36.79 | 9.86 | 31 | 103888 | 1895 | 50499310 |
Intentional self-injury | 36.19 | 9.86 | 3 | 103916 | 23109 | 50478096 |
Status asthmaticus | 35.91 | 9.86 | 22 | 103897 | 811 | 50500394 |
Type 2 diabetes mellitus | 35.61 | 9.86 | 13 | 103906 | 34362 | 50466843 |
C-reactive protein abnormal | 35.43 | 9.86 | 7 | 103912 | 27802 | 50473403 |
Swollen tongue | 35.21 | 9.86 | 134 | 103785 | 28496 | 50472709 |
Unresponsive to stimuli | 35.00 | 9.86 | 140 | 103779 | 30469 | 50470736 |
Administration site reaction | 34.77 | 9.86 | 14 | 103905 | 202 | 50501003 |
Administration site bruise | 34.55 | 9.86 | 15 | 103904 | 264 | 50500941 |
Mobility decreased | 34.55 | 9.86 | 70 | 103849 | 79878 | 50421327 |
Administration site pruritus | 34.50 | 9.86 | 15 | 103904 | 265 | 50500940 |
Infection susceptibility increased | 34.46 | 9.86 | 34 | 103885 | 2550 | 50498655 |
Pancytopenia | 33.47 | 9.86 | 77 | 103842 | 83953 | 50417252 |
Stomatitis | 33.43 | 9.86 | 102 | 103817 | 101242 | 50399963 |
Platelet aggregation inhibition | 33.41 | 9.86 | 12 | 103907 | 124 | 50501081 |
Anaesthetic complication neurological | 33.38 | 9.86 | 13 | 103906 | 171 | 50501034 |
Anaphylactoid reaction | 33.31 | 9.86 | 38 | 103881 | 3368 | 50497837 |
Injection site hypoaesthesia | 33.03 | 9.86 | 16 | 103903 | 366 | 50500839 |
Procedural complication | 33.03 | 9.86 | 45 | 103874 | 4778 | 50496427 |
Laryngeal oedema | 32.88 | 9.86 | 46 | 103873 | 5007 | 50496198 |
Blood pressure decreased | 32.88 | 9.86 | 212 | 103707 | 55697 | 50445508 |
Inhibitory drug interaction | 32.83 | 9.86 | 31 | 103888 | 2202 | 50499003 |
Circulatory collapse | 32.79 | 9.86 | 103 | 103816 | 19897 | 50481308 |
Swelling | 32.61 | 9.86 | 260 | 103659 | 200612 | 50300593 |
Uterine hypertonus | 32.53 | 9.86 | 14 | 103905 | 241 | 50500964 |
Nerve root injury | 32.50 | 9.86 | 9 | 103910 | 35 | 50501170 |
Injection site injury | 32.48 | 9.86 | 18 | 103901 | 548 | 50500657 |
Asthenia | 31.96 | 9.86 | 462 | 103457 | 318580 | 50182625 |
Anterior chamber cell | 31.94 | 9.86 | 17 | 103902 | 477 | 50500728 |
Blister | 31.87 | 9.86 | 81 | 103838 | 85337 | 50415868 |
Hypoaesthesia oral | 31.82 | 9.86 | 69 | 103850 | 10659 | 50490546 |
Product contamination microbial | 31.71 | 9.86 | 13 | 103906 | 197 | 50501008 |
Kidney infection | 31.16 | 9.86 | 97 | 103822 | 18649 | 50482556 |
Injection site coldness | 31.01 | 9.86 | 10 | 103909 | 72 | 50501133 |
Administration site extravasation | 30.97 | 9.86 | 19 | 103900 | 702 | 50500503 |
Chills | 30.87 | 9.86 | 319 | 103600 | 96368 | 50404837 |
Ophthalmoplegia | 30.73 | 9.86 | 24 | 103895 | 1316 | 50499889 |
Disease progression | 30.55 | 9.86 | 98 | 103821 | 95768 | 50405437 |
Anxiety | 30.36 | 9.86 | 523 | 103396 | 177083 | 50324122 |
Mydriasis | 29.99 | 9.86 | 67 | 103852 | 10560 | 50490645 |
Wheezing | 29.84 | 9.86 | 224 | 103695 | 61823 | 50439382 |
Sinus tachycardia | 29.68 | 9.86 | 104 | 103815 | 21250 | 50479955 |
Eye infection | 29.63 | 9.86 | 62 | 103857 | 9344 | 50491861 |
Infusion site warmth | 29.30 | 9.86 | 24 | 103895 | 1410 | 50499795 |
Leukopenia | 29.28 | 9.86 | 59 | 103860 | 67469 | 50433736 |
Type I hypersensitivity | 29.27 | 9.86 | 30 | 103889 | 2355 | 50498850 |
Psoriatic arthropathy | 29.25 | 9.86 | 32 | 103887 | 47000 | 50454205 |
Peripheral swelling | 29.22 | 9.86 | 276 | 103643 | 205660 | 50295545 |
Gas gangrene | 29.16 | 9.86 | 10 | 103909 | 89 | 50501116 |
Malignant neoplasm progression | 29.13 | 9.86 | 60 | 103859 | 68064 | 50433141 |
Condition aggravated | 29.10 | 9.86 | 432 | 103487 | 296626 | 50204579 |
Thrombocytopenia | 29.04 | 9.86 | 149 | 103770 | 127524 | 50373681 |
Drug reaction with eosinophilia and systemic symptoms | 29.02 | 9.86 | 11 | 103908 | 28413 | 50472792 |
Chest discomfort | 28.70 | 9.86 | 304 | 103615 | 92418 | 50408787 |
Neuromuscular block prolonged | 28.64 | 9.86 | 16 | 103903 | 495 | 50500710 |
Cyanosis | 28.48 | 9.86 | 82 | 103837 | 15102 | 50486103 |
Hyperaesthesia | 28.27 | 9.86 | 56 | 103863 | 8117 | 50493088 |
Bursitis infective | 28.08 | 9.86 | 22 | 103897 | 1212 | 50499993 |
Fungal infection | 28.05 | 9.86 | 129 | 103790 | 29836 | 50471369 |
Vasospasm | 27.96 | 9.86 | 17 | 103902 | 618 | 50500587 |
Vasoplegia syndrome | 27.85 | 9.86 | 21 | 103898 | 1093 | 50500112 |
Infusion site discomfort | 27.55 | 9.86 | 19 | 103900 | 859 | 50500346 |
Aqueous fibrin | 27.53 | 9.86 | 9 | 103910 | 68 | 50501137 |
Urinary tract infection | 27.32 | 9.86 | 627 | 103292 | 223393 | 50277812 |
Blood cholesterol increased | 26.82 | 9.86 | 45 | 103874 | 55170 | 50446035 |
Blood pH decreased | 26.78 | 9.86 | 29 | 103890 | 2426 | 50498779 |
Liver function test abnormal | 26.67 | 9.86 | 31 | 103888 | 44308 | 50456897 |
Anaphylactoid shock | 26.54 | 9.86 | 13 | 103906 | 305 | 50500900 |
Peripheral nerve injury | 26.46 | 9.86 | 14 | 103905 | 388 | 50500817 |
Bladder prolapse | 26.24 | 9.86 | 25 | 103894 | 1796 | 50499409 |
Myopathy toxic | 26.23 | 9.86 | 14 | 103905 | 395 | 50500810 |
Eyelid rash | 26.16 | 9.86 | 9 | 103910 | 81 | 50501124 |
Meningitis chemical | 26.13 | 9.86 | 10 | 103909 | 125 | 50501080 |
Ventricular extrasystoles | 26.06 | 9.86 | 63 | 103856 | 10453 | 50490752 |
Death | 26.05 | 9.86 | 491 | 103428 | 324888 | 50176317 |
Throat tightness | 25.99 | 9.86 | 98 | 103821 | 20749 | 50480456 |
PO2 decreased | 25.91 | 9.86 | 22 | 103897 | 1359 | 50499846 |
Corneal epithelium defect | 25.90 | 9.86 | 13 | 103906 | 322 | 50500883 |
Systemic toxicity | 25.75 | 9.86 | 7 | 103912 | 25 | 50501180 |
Fear of eating | 25.71 | 9.86 | 13 | 103906 | 327 | 50500878 |
Cardiac failure congestive | 25.69 | 9.86 | 88 | 103831 | 84294 | 50416911 |
Pneumocephalus | 25.37 | 9.86 | 10 | 103909 | 136 | 50501069 |
Removal of foreign body | 25.28 | 9.86 | 6 | 103913 | 10 | 50501195 |
Paraesthesia oral | 24.89 | 9.86 | 68 | 103851 | 12153 | 50489052 |
Paralysis | 24.87 | 9.86 | 55 | 103864 | 8609 | 50492596 |
Hip arthroplasty | 24.70 | 9.86 | 16 | 103903 | 30413 | 50470792 |
Pharyngeal swelling | 24.56 | 9.86 | 38 | 103881 | 4528 | 50496677 |
Cystitis | 24.39 | 9.86 | 166 | 103753 | 44398 | 50456807 |
Upper airway obstruction | 24.36 | 9.86 | 15 | 103904 | 558 | 50500647 |
Pharyngitis streptococcal | 24.26 | 9.86 | 55 | 103864 | 8753 | 50492452 |
Cholestasis | 24.05 | 9.86 | 11 | 103908 | 25390 | 50475815 |
Myocardial ischaemia | 24.03 | 9.86 | 65 | 103854 | 11548 | 50489657 |
Troponin T increased | 23.95 | 9.86 | 18 | 103901 | 932 | 50500273 |
Parophthalmia | 23.73 | 9.86 | 12 | 103907 | 302 | 50500903 |
Retinal vasculitis | 23.66 | 9.86 | 17 | 103902 | 821 | 50500384 |
Seasonal allergy | 23.53 | 9.86 | 75 | 103844 | 14601 | 50486604 |
Septic arthritis staphylococcal | 23.45 | 9.86 | 13 | 103906 | 396 | 50500809 |
Multiple organ dysfunction syndrome | 23.24 | 9.86 | 180 | 103739 | 50157 | 50451048 |
Sensory loss | 23.21 | 9.86 | 50 | 103869 | 7688 | 50493517 |
Bundle branch block left | 23.15 | 9.86 | 44 | 103875 | 6186 | 50495019 |
Respiratory acidosis | 22.93 | 9.86 | 43 | 103876 | 5985 | 50495220 |
Inappropriate schedule of product administration | 22.93 | 9.86 | 237 | 103682 | 71594 | 50429611 |
Loss of personal independence in daily activities | 22.74 | 9.86 | 71 | 103848 | 69979 | 50431226 |
Knee arthroplasty | 22.73 | 9.86 | 24 | 103895 | 35822 | 50465383 |
Glucose tolerance impaired | 22.65 | 9.86 | 39 | 103880 | 5079 | 50496126 |
Cranial nerve palsies multiple | 22.16 | 9.86 | 6 | 103913 | 21 | 50501184 |
Trigemino-cardiac reflex | 22.00 | 9.86 | 7 | 103912 | 48 | 50501157 |
Abdominal pain upper | 21.96 | 9.86 | 215 | 103704 | 159094 | 50342111 |
Drug ineffective for unapproved indication | 21.71 | 9.86 | 94 | 103825 | 21187 | 50480018 |
Paraplegia | 21.70 | 9.86 | 26 | 103893 | 2428 | 50498777 |
Dermatitis contact | 21.64 | 9.86 | 52 | 103867 | 8594 | 50492611 |
Nerve block | 21.57 | 9.86 | 13 | 103906 | 465 | 50500740 |
Gastroenteritis viral | 21.53 | 9.86 | 86 | 103833 | 18700 | 50482505 |
Osteonecrosis of jaw | 21.51 | 9.86 | 21 | 103898 | 32505 | 50468700 |
Influenza like illness | 21.49 | 9.86 | 196 | 103723 | 57263 | 50443942 |
Rectal prolapse | 21.47 | 9.86 | 22 | 103897 | 1727 | 50499478 |
PCO2 increased | 21.02 | 9.86 | 18 | 103901 | 1125 | 50500080 |
Arterial spasm | 20.85 | 9.86 | 7 | 103912 | 58 | 50501147 |
Spinal epidural haemorrhage | 20.76 | 9.86 | 8 | 103911 | 102 | 50501103 |
Red blood cell sedimentation rate increased | 20.62 | 9.86 | 18 | 103901 | 29398 | 50471807 |
Fear of death | 20.38 | 9.86 | 16 | 103903 | 884 | 50500321 |
Stress | 20.37 | 9.86 | 184 | 103735 | 53609 | 50447596 |
Blood lactic acid increased | 20.21 | 9.86 | 39 | 103880 | 5546 | 50495659 |
Electrocardiogram T wave inversion | 20.20 | 9.86 | 29 | 103890 | 3232 | 50497973 |
Postresuscitation encephalopathy | 20.16 | 9.86 | 5 | 103914 | 11 | 50501194 |
Drug resistance | 19.98 | 9.86 | 7 | 103912 | 18982 | 50482223 |
Hepatotoxicity | 19.90 | 9.86 | 16 | 103903 | 27210 | 50473995 |
Drug abuse | 19.90 | 9.86 | 60 | 103859 | 59786 | 50441419 |
Skin infection | 19.87 | 9.86 | 63 | 103856 | 12228 | 50488977 |
Axillary nerve injury | 19.86 | 9.86 | 5 | 103914 | 12 | 50501193 |
Harlequin syndrome | 19.68 | 9.86 | 6 | 103913 | 35 | 50501170 |
Orthostatic hypotension | 19.53 | 9.86 | 19 | 103900 | 29462 | 50471743 |
Administration site nodule | 19.40 | 9.86 | 6 | 103913 | 37 | 50501168 |
Ischaemia | 19.36 | 9.86 | 33 | 103886 | 4264 | 50496941 |
Local reaction | 19.35 | 9.86 | 13 | 103906 | 563 | 50500642 |
Lung hyperinflation | 19.33 | 9.86 | 17 | 103902 | 1101 | 50500104 |
Administration site irritation | 19.27 | 9.86 | 6 | 103913 | 38 | 50501167 |
Administration site discolouration | 19.27 | 9.86 | 6 | 103913 | 38 | 50501167 |
Vitamin D increased | 19.26 | 9.86 | 13 | 103906 | 567 | 50500638 |
Injection site inflammation | 19.13 | 9.86 | 28 | 103891 | 3177 | 50498028 |
Spinal anaesthesia | 18.88 | 9.86 | 6 | 103913 | 41 | 50501164 |
Liver injury | 18.86 | 9.86 | 14 | 103905 | 24792 | 50476413 |
Administration site haemorrhage | 18.78 | 9.86 | 7 | 103912 | 81 | 50501124 |
Jaundice | 18.74 | 9.86 | 16 | 103903 | 26413 | 50474792 |
Atonic urinary bladder | 18.63 | 9.86 | 7 | 103912 | 83 | 50501122 |
Device expulsion | 18.61 | 9.86 | 19 | 103900 | 28803 | 50472402 |
Vasoconstriction | 18.60 | 9.86 | 12 | 103907 | 485 | 50500720 |
Oral herpes | 18.50 | 9.86 | 88 | 103831 | 20637 | 50480568 |
Loss of consciousness | 18.43 | 9.86 | 309 | 103610 | 104044 | 50397161 |
Sinus disorder | 18.42 | 9.86 | 81 | 103838 | 18377 | 50482828 |
Psoriasis | 18.37 | 9.86 | 76 | 103843 | 68924 | 50432281 |
Neurogenic shock | 18.36 | 9.86 | 10 | 103909 | 294 | 50500911 |
Mean arterial pressure decreased | 18.26 | 9.86 | 8 | 103911 | 144 | 50501061 |
Irritable bowel syndrome | 18.25 | 9.86 | 50 | 103869 | 51391 | 50449814 |
Product dose omission issue | 18.09 | 9.86 | 500 | 103419 | 183338 | 50317867 |
Conjunctival oedema | 18.05 | 9.86 | 13 | 103906 | 630 | 50500575 |
Hepatocellular injury | 18.04 | 9.86 | 16 | 103903 | 25931 | 50475274 |
Reversible cerebral vasoconstriction syndrome | 18.01 | 9.86 | 22 | 103897 | 2097 | 50499108 |
Agranulocytosis | 17.75 | 9.86 | 11 | 103908 | 21410 | 50479795 |
Heart rate increased | 17.62 | 9.86 | 239 | 103680 | 77011 | 50424194 |
Peritonitis | 17.55 | 9.86 | 5 | 103914 | 15481 | 50485724 |
Meningitis aseptic | 17.55 | 9.86 | 31 | 103888 | 4121 | 50497084 |
Eyelid ptosis | 17.45 | 9.86 | 39 | 103880 | 6148 | 50495057 |
Punctate keratitis | 17.35 | 9.86 | 12 | 103907 | 545 | 50500660 |
Phrenic nerve paralysis | 17.32 | 9.86 | 7 | 103912 | 102 | 50501103 |
Enzyme induction | 17.24 | 9.86 | 6 | 103913 | 56 | 50501149 |
Systolic anterior motion of mitral valve | 17.21 | 9.86 | 5 | 103914 | 24 | 50501181 |
Extremity necrosis | 17.15 | 9.86 | 18 | 103901 | 1453 | 50499752 |
Product measured potency issue | 17.14 | 9.86 | 7 | 103912 | 105 | 50501100 |
Retinal artery occlusion | 16.99 | 9.86 | 18 | 103901 | 1469 | 50499736 |
Hypocalcaemia | 16.95 | 9.86 | 18 | 103901 | 26798 | 50474407 |
Apnoeic attack | 16.80 | 9.86 | 9 | 103910 | 256 | 50500949 |
Sinus operation | 16.72 | 9.86 | 19 | 103900 | 1677 | 50499528 |
Vocal cord dysfunction | 16.68 | 9.86 | 10 | 103909 | 354 | 50500851 |
Glossoptosis | 16.62 | 9.86 | 6 | 103913 | 63 | 50501142 |
Sleep disorder | 16.59 | 9.86 | 61 | 103858 | 57222 | 50443983 |
No adverse event | 16.58 | 9.86 | 122 | 103797 | 33456 | 50467749 |
Poor quality sleep | 16.58 | 9.86 | 73 | 103846 | 16573 | 50484632 |
Inability to afford medication | 16.56 | 9.86 | 18 | 103901 | 1512 | 50499693 |
Abdominal pain | 16.34 | 9.86 | 365 | 103554 | 235863 | 50265342 |
White blood cell count decreased | 16.30 | 9.86 | 157 | 103762 | 116565 | 50384640 |
ECG signs of myocardial ischaemia | 16.21 | 9.86 | 6 | 103913 | 68 | 50501137 |
Infusion site discolouration | 16.16 | 9.86 | 12 | 103907 | 610 | 50500595 |
Arachnoiditis | 16.15 | 9.86 | 9 | 103910 | 277 | 50500928 |
Accidental overdose | 16.05 | 9.86 | 81 | 103838 | 19452 | 50481753 |
Propofol infusion syndrome | 16.03 | 9.86 | 13 | 103906 | 753 | 50500452 |
Muscle tightness | 15.99 | 9.86 | 52 | 103867 | 10228 | 50490977 |
Brain injury | 15.95 | 9.86 | 37 | 103882 | 5977 | 50495228 |
Neoplasm progression | 15.86 | 9.86 | 22 | 103897 | 29135 | 50472070 |
Cold sweat | 15.81 | 9.86 | 53 | 103866 | 10591 | 50490614 |
Vaccination complication | 15.65 | 9.86 | 13 | 103906 | 779 | 50500426 |
Gastrointestinal disorder | 15.43 | 9.86 | 122 | 103797 | 94334 | 50406871 |
Therapeutic product effect prolonged | 15.40 | 9.86 | 9 | 103910 | 304 | 50500901 |
Depressed mood | 15.38 | 9.86 | 29 | 103890 | 33994 | 50467211 |
Gastrointestinal haemorrhage | 15.32 | 9.86 | 88 | 103831 | 73233 | 50427972 |
Adverse event | 15.18 | 9.86 | 43 | 103876 | 43720 | 50457485 |
Respiratory distress | 15.18 | 9.86 | 111 | 103808 | 30378 | 50470827 |
Rash | 15.18 | 9.86 | 739 | 103180 | 436732 | 50064473 |
Interstitial lung disease | 15.16 | 9.86 | 57 | 103862 | 53119 | 50448086 |
Product adhesion issue | 15.08 | 9.86 | 30 | 103889 | 4362 | 50496843 |
Spinal epidural haematoma | 15.06 | 9.86 | 14 | 103905 | 975 | 50500230 |
Eye infarction | 15.05 | 9.86 | 5 | 103914 | 40 | 50501165 |
Distributive shock | 14.98 | 9.86 | 13 | 103906 | 827 | 50500378 |
Prescribed underdose | 14.95 | 9.86 | 7 | 103912 | 15942 | 50485263 |
Tooth infection | 14.91 | 9.86 | 63 | 103856 | 14049 | 50487156 |
Musculoskeletal pain | 14.88 | 9.86 | 87 | 103832 | 72090 | 50429115 |
Pneumonia mycoplasmal | 14.86 | 9.86 | 13 | 103906 | 836 | 50500369 |
Gastric infection | 14.85 | 9.86 | 24 | 103895 | 2968 | 50498237 |
Myocardial necrosis marker increased | 14.85 | 9.86 | 17 | 103902 | 1513 | 50499692 |
Blood pressure increased | 14.80 | 9.86 | 368 | 103551 | 132764 | 50368441 |
Respiratory tract oedema | 14.78 | 9.86 | 10 | 103909 | 438 | 50500767 |
Eye inflammation | 14.76 | 9.86 | 29 | 103890 | 4179 | 50497026 |
Platelet count decreased | 14.70 | 9.86 | 134 | 103785 | 100592 | 50400613 |
Respiratory depression | 14.59 | 9.86 | 56 | 103863 | 11954 | 50489251 |
Infusion site induration | 14.55 | 9.86 | 13 | 103906 | 860 | 50500345 |
Cardiac assistance device user | 14.53 | 9.86 | 5 | 103914 | 45 | 50501160 |
Spinal cord infarction | 14.51 | 9.86 | 8 | 103911 | 241 | 50500964 |
Accidental exposure to product by child | 14.46 | 9.86 | 14 | 103905 | 1026 | 50500179 |
Meningitis | 14.45 | 9.86 | 36 | 103883 | 6085 | 50495120 |
Administration site scar | 14.43 | 9.86 | 5 | 103914 | 46 | 50501159 |
Apnoea | 14.42 | 9.86 | 39 | 103880 | 6927 | 50494278 |
Hypercalcaemia | 14.40 | 9.86 | 16 | 103903 | 23336 | 50477869 |
Postpartum disorder | 14.36 | 9.86 | 4 | 103915 | 16 | 50501189 |
Status epilepticus | 14.28 | 9.86 | 60 | 103859 | 13346 | 50487859 |
Epidural analgesia | 14.25 | 9.86 | 5 | 103914 | 48 | 50501157 |
Delayed recovery from anaesthesia | 14.19 | 9.86 | 12 | 103907 | 737 | 50500468 |
Visual acuity reduced | 14.15 | 9.86 | 80 | 103839 | 20059 | 50481146 |
Mast cell activation syndrome | 14.08 | 9.86 | 9 | 103910 | 358 | 50500847 |
Hypercapnia | 14.00 | 9.86 | 30 | 103889 | 4597 | 50496608 |
SARS-CoV-2 test positive | 13.86 | 9.86 | 30 | 103889 | 4629 | 50496576 |
Neuroleptic malignant syndrome | 13.77 | 9.86 | 3 | 103916 | 11127 | 50490078 |
Tracheal deviation | 13.72 | 9.86 | 5 | 103914 | 54 | 50501151 |
Constipation | 13.69 | 9.86 | 284 | 103635 | 185424 | 50315781 |
Systolic dysfunction | 13.69 | 9.86 | 16 | 103903 | 1456 | 50499749 |
Blood pressure immeasurable | 13.67 | 9.86 | 14 | 103905 | 1098 | 50500107 |
Chondromalacia | 13.67 | 9.86 | 8 | 103911 | 271 | 50500934 |
Trigeminal palsy | 13.64 | 9.86 | 4 | 103915 | 20 | 50501185 |
Forced vital capacity abnormal | 13.64 | 9.86 | 4 | 103915 | 20 | 50501185 |
Incision site rash | 13.64 | 9.86 | 4 | 103915 | 20 | 50501185 |
Left ventricular dysfunction | 13.60 | 9.86 | 50 | 103869 | 10456 | 50490749 |
Malabsorption from administration site | 13.60 | 9.86 | 6 | 103913 | 110 | 50501095 |
Caffeine allergy | 13.47 | 9.86 | 4 | 103915 | 21 | 50501184 |
Colour blindness | 13.46 | 9.86 | 8 | 103911 | 279 | 50500926 |
Diplegia | 13.42 | 9.86 | 13 | 103906 | 953 | 50500252 |
Supraventricular tachycardia | 13.41 | 9.86 | 57 | 103862 | 12744 | 50488461 |
Normal newborn | 13.40 | 9.86 | 37 | 103882 | 6654 | 50494551 |
Inadequate analgesia | 13.36 | 9.86 | 21 | 103898 | 2537 | 50498668 |
Liver disorder | 13.34 | 9.86 | 36 | 103883 | 37186 | 50464019 |
Foetal heart rate abnormal | 13.34 | 9.86 | 10 | 103909 | 516 | 50500689 |
Arthritis | 13.25 | 9.86 | 114 | 103805 | 86607 | 50414598 |
Gastroenteritis | 13.24 | 9.86 | 17 | 103902 | 23264 | 50477941 |
Device use issue | 13.21 | 9.86 | 18 | 103901 | 1911 | 50499294 |
Administration site rash | 13.18 | 9.86 | 5 | 103914 | 61 | 50501144 |
Creatinine renal clearance decreased | 13.17 | 9.86 | 4 | 103915 | 11877 | 50489328 |
Hypomagnesaemia | 13.07 | 9.86 | 17 | 103902 | 23139 | 50478066 |
Spinal cord oedema | 13.03 | 9.86 | 6 | 103913 | 122 | 50501083 |
Procedural haemorrhage | 13.01 | 9.86 | 20 | 103899 | 2370 | 50498835 |
Post-anoxic myoclonus | 12.89 | 9.86 | 4 | 103915 | 25 | 50501180 |
Pain in extremity | 12.85 | 9.86 | 445 | 103474 | 272420 | 50228785 |
Therapeutic product effect incomplete | 12.81 | 9.86 | 123 | 103796 | 91392 | 50409813 |
CSF pressure increased | 12.81 | 9.86 | 6 | 103913 | 127 | 50501078 |
Irregular breathing | 12.74 | 9.86 | 8 | 103911 | 308 | 50500897 |
Product distribution issue | 12.63 | 9.86 | 11 | 103908 | 703 | 50500502 |
Product contamination | 12.62 | 9.86 | 10 | 103909 | 560 | 50500645 |
Off label use | 12.51 | 9.86 | 823 | 103096 | 473603 | 50027602 |
International normalised ratio increased | 12.46 | 9.86 | 46 | 103873 | 43106 | 50458099 |
Nail bed tenderness | 12.45 | 9.86 | 8 | 103911 | 321 | 50500884 |
Pain in jaw | 12.43 | 9.86 | 39 | 103880 | 38389 | 50462816 |
Administration site mass | 12.38 | 9.86 | 4 | 103915 | 29 | 50501176 |
Genital ulceration | 12.36 | 9.86 | 9 | 103910 | 444 | 50500761 |
Vaccination site rash | 12.29 | 9.86 | 3 | 103916 | 6 | 50501199 |
Anal sphincter atony | 12.20 | 9.86 | 7 | 103912 | 228 | 50500977 |
Propionibacterium infection | 12.15 | 9.86 | 4 | 103915 | 31 | 50501174 |
Metastases to liver | 12.15 | 9.86 | 14 | 103905 | 20090 | 50481115 |
Smoke sensitivity | 12.14 | 9.86 | 8 | 103911 | 335 | 50500870 |
Neutropenic sepsis | 12.09 | 9.86 | 7 | 103912 | 14140 | 50487065 |
Inflammation | 12.06 | 9.86 | 68 | 103851 | 56844 | 50444361 |
Limb injury | 12.03 | 9.86 | 77 | 103842 | 20173 | 50481032 |
Hypoxia | 12.00 | 9.86 | 159 | 103760 | 50964 | 50450241 |
Influenza | 11.96 | 9.86 | 254 | 103665 | 89284 | 50411921 |
Malignant melanoma | 11.96 | 9.86 | 3 | 103916 | 10105 | 50491100 |
Device issue | 11.90 | 9.86 | 76 | 103843 | 19896 | 50481309 |
Device ineffective | 11.87 | 9.86 | 6 | 103913 | 151 | 50501054 |
Poor quality product administered | 11.85 | 9.86 | 21 | 103898 | 2798 | 50498407 |
Optic atrophy | 11.80 | 9.86 | 13 | 103906 | 1109 | 50500096 |
Sinus bradycardia | 11.78 | 9.86 | 56 | 103863 | 13127 | 50488078 |
Foetal exposure during pregnancy | 11.77 | 9.86 | 24 | 103895 | 27335 | 50473870 |
Blindness | 11.74 | 9.86 | 68 | 103851 | 17201 | 50484004 |
Cutis laxa | 11.72 | 9.86 | 6 | 103913 | 155 | 50501050 |
Cholestasis of pregnancy | 11.71 | 9.86 | 13 | 103906 | 1118 | 50500087 |
Poor venous access | 11.58 | 9.86 | 47 | 103872 | 10293 | 50490912 |
Electrocardiogram U wave present | 11.52 | 9.86 | 5 | 103914 | 88 | 50501117 |
Femur fracture | 11.45 | 9.86 | 39 | 103880 | 37425 | 50463780 |
Decreased ventricular preload | 11.43 | 9.86 | 3 | 103916 | 9 | 50501196 |
Application site alopecia | 11.43 | 9.86 | 3 | 103916 | 9 | 50501196 |
Body dysmorphic disorder | 11.43 | 9.86 | 7 | 103912 | 258 | 50500947 |
Urticaria chronic | 11.42 | 9.86 | 9 | 103910 | 500 | 50500705 |
Procedural anxiety | 11.34 | 9.86 | 10 | 103909 | 650 | 50500555 |
Mastocytosis | 11.27 | 9.86 | 9 | 103910 | 510 | 50500695 |
Mental status changes | 11.25 | 9.86 | 119 | 103800 | 36153 | 50465052 |
Vascular resistance systemic decreased | 11.22 | 9.86 | 5 | 103914 | 94 | 50501111 |
Haematochezia | 11.20 | 9.86 | 43 | 103876 | 39839 | 50461366 |
Bradycardia foetal | 11.20 | 9.86 | 8 | 103911 | 383 | 50500822 |
XIIth nerve injury | 11.19 | 9.86 | 3 | 103916 | 10 | 50501195 |
Fall | 11.17 | 9.86 | 568 | 103351 | 334364 | 50166841 |
Capillary nail refill test abnormal | 11.16 | 9.86 | 4 | 103915 | 41 | 50501164 |
Orbital infection | 11.16 | 9.86 | 4 | 103915 | 41 | 50501164 |
Balance disorder | 11.14 | 9.86 | 92 | 103827 | 70498 | 50430707 |
Cardiac arrest neonatal | 11.12 | 9.86 | 5 | 103914 | 96 | 50501109 |
Gamma-glutamyltransferase increased | 11.11 | 9.86 | 28 | 103891 | 29595 | 50471610 |
Autonomic neuropathy | 11.11 | 9.86 | 12 | 103907 | 1001 | 50500204 |
Alanine aminotransferase increased | 11.04 | 9.86 | 122 | 103797 | 88237 | 50412968 |
Exposure during pregnancy | 11.02 | 9.86 | 326 | 103593 | 120689 | 50380516 |
Heart rate decreased | 10.98 | 9.86 | 119 | 103800 | 36378 | 50464827 |
Epinephrine increased | 10.97 | 9.86 | 3 | 103916 | 11 | 50501194 |
Tachypnoea | 10.97 | 9.86 | 59 | 103860 | 14518 | 50486687 |
Foot deformity | 10.95 | 9.86 | 14 | 103905 | 19196 | 50482009 |
Biopsy lung | 10.94 | 9.86 | 6 | 103913 | 179 | 50501026 |
Lip disorder | 10.94 | 9.86 | 13 | 103906 | 1204 | 50500001 |
Anaphylactoid syndrome of pregnancy | 10.91 | 9.86 | 4 | 103915 | 44 | 50501161 |
Hepatic cirrhosis | 10.88 | 9.86 | 12 | 103907 | 17565 | 50483640 |
Corneal abrasion | 10.87 | 9.86 | 11 | 103908 | 851 | 50500354 |
Tremor | 10.87 | 9.86 | 311 | 103608 | 114592 | 50386613 |
Food allergy | 10.77 | 9.86 | 39 | 103880 | 8098 | 50493107 |
Injection site abscess | 10.77 | 9.86 | 12 | 103907 | 1037 | 50500168 |
Infusion site oedema | 10.71 | 9.86 | 9 | 103910 | 548 | 50500657 |
Ill-defined disorder | 10.68 | 9.86 | 67 | 103852 | 54587 | 50446618 |
Transaminases increased | 10.67 | 9.86 | 26 | 103893 | 27798 | 50473407 |
Paranasal cyst | 10.67 | 9.86 | 7 | 103912 | 291 | 50500914 |
Neurotoxicity | 10.65 | 9.86 | 59 | 103860 | 14681 | 50486524 |
Ventricular arrhythmia | 10.64 | 9.86 | 22 | 103897 | 3287 | 50497918 |
Hypoxic-ischaemic encephalopathy | 10.59 | 9.86 | 24 | 103895 | 3818 | 50497387 |
Overdose | 10.59 | 9.86 | 274 | 103645 | 99453 | 50401752 |
Victim of spousal abuse | 10.58 | 9.86 | 3 | 103916 | 13 | 50501192 |
Intraocular pressure increased | 10.55 | 9.86 | 30 | 103889 | 5486 | 50495719 |
N-terminal prohormone brain natriuretic peptide | 10.53 | 9.86 | 4 | 103915 | 49 | 50501156 |
Scar | 10.41 | 9.86 | 50 | 103869 | 11768 | 50489437 |
Urticarial vasculitis | 10.41 | 9.86 | 9 | 103910 | 570 | 50500635 |
Nystagmus | 10.40 | 9.86 | 30 | 103889 | 5531 | 50495674 |
Melaena | 10.38 | 9.86 | 25 | 103894 | 26839 | 50474366 |
Akinesia | 10.29 | 9.86 | 14 | 103905 | 1485 | 50499720 |
Aplastic anaemia | 10.26 | 9.86 | 37 | 103882 | 7666 | 50493539 |
Ehlers-Danlos syndrome | 10.26 | 9.86 | 5 | 103914 | 116 | 50501089 |
Electrocardiogram P wave abnormal | 10.23 | 9.86 | 6 | 103913 | 204 | 50501001 |
Arthritis fungal | 10.23 | 9.86 | 3 | 103916 | 15 | 50501190 |
Coccygectomy | 10.23 | 9.86 | 3 | 103916 | 15 | 50501190 |
Vitamin E decreased | 10.23 | 9.86 | 3 | 103916 | 15 | 50501190 |
Tongue pruritus | 10.22 | 9.86 | 8 | 103911 | 440 | 50500765 |
Eosinophilia | 10.22 | 9.86 | 14 | 103905 | 18638 | 50482567 |
Quadriplegia | 10.21 | 9.86 | 15 | 103904 | 1708 | 50499497 |
Airway complication of anaesthesia | 10.20 | 9.86 | 6 | 103913 | 205 | 50501000 |
Arthritis bacterial | 10.17 | 9.86 | 30 | 103889 | 5599 | 50495606 |
Diabetes mellitus | 10.16 | 9.86 | 59 | 103860 | 48974 | 50452231 |
Anal skin tags | 10.10 | 9.86 | 7 | 103912 | 319 | 50500886 |
Hyperlactacidaemia | 10.07 | 9.86 | 18 | 103901 | 2415 | 50498790 |
Epidural haemorrhage | 10.07 | 9.86 | 5 | 103914 | 121 | 50501084 |
Vitreous haemorrhage | 10.04 | 9.86 | 15 | 103904 | 1733 | 50499472 |
Fear-related avoidance of activities | 10.03 | 9.86 | 5 | 103914 | 122 | 50501083 |
Blood bilirubin increased | 10.03 | 9.86 | 33 | 103886 | 32005 | 50469200 |
Gait disturbance | 10.02 | 9.86 | 233 | 103686 | 149772 | 50351433 |
Drug hypersensitivity | 10.00 | 9.86 | 620 | 103299 | 250390 | 50250815 |
Implant site swelling | 9.98 | 9.86 | 8 | 103911 | 456 | 50500749 |
Compartment syndrome | 9.97 | 9.86 | 16 | 103903 | 1966 | 50499239 |
Medical device site infection | 9.97 | 9.86 | 6 | 103913 | 214 | 50500991 |
Product administration error | 9.97 | 9.86 | 72 | 103847 | 19627 | 50481578 |
Depression | 9.95 | 9.86 | 261 | 103658 | 165162 | 50336043 |
Infusion site scar | 9.91 | 9.86 | 7 | 103912 | 329 | 50500876 |
Pupil fixed | 9.91 | 9.86 | 14 | 103905 | 1538 | 50499667 |
Scarlet fever | 9.88 | 9.86 | 5 | 103914 | 126 | 50501079 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Device failure | 358.07 | 10.60 | 137 | 55620 | 1879 | 29516891 |
Anaphylactic reaction | 321.51 | 10.60 | 324 | 55433 | 27249 | 29491521 |
Sinusitis | 274.40 | 10.60 | 331 | 55426 | 34019 | 29484751 |
Anaesthetic complication | 249.52 | 10.60 | 87 | 55670 | 899 | 29517871 |
Drug ineffective | 247.00 | 10.60 | 1338 | 54419 | 361832 | 29156938 |
Anaphylactic shock | 217.63 | 10.60 | 189 | 55568 | 13147 | 29505623 |
Cardiac arrest | 202.26 | 10.60 | 477 | 55280 | 85114 | 29433656 |
Toxic anterior segment syndrome | 186.12 | 10.60 | 71 | 55686 | 965 | 29517805 |
Fear | 165.87 | 10.60 | 140 | 55617 | 9364 | 29509406 |
Hereditary angioedema | 161.74 | 10.60 | 59 | 55698 | 702 | 29518068 |
Chondrolysis | 158.22 | 10.60 | 38 | 55719 | 78 | 29518692 |
Injury | 154.40 | 10.60 | 185 | 55572 | 18861 | 29499909 |
Renal injury | 141.60 | 10.60 | 132 | 55625 | 10070 | 29508700 |
Methaemoglobinaemia | 135.36 | 10.60 | 76 | 55681 | 2595 | 29516175 |
Ventricular tachycardia | 129.59 | 10.60 | 185 | 55572 | 22389 | 29496381 |
Hypotension | 129.16 | 10.60 | 713 | 55044 | 193641 | 29325129 |
Anhedonia | 117.36 | 10.60 | 102 | 55655 | 7098 | 29511672 |
Stress cardiomyopathy | 115.69 | 10.60 | 58 | 55699 | 1566 | 29517204 |
Emotional distress | 114.30 | 10.60 | 136 | 55621 | 13759 | 29505011 |
Accidental exposure to product | 111.97 | 10.60 | 119 | 55638 | 10634 | 29508136 |
Ear infection | 103.26 | 10.60 | 100 | 55657 | 8000 | 29510770 |
Injection site pallor | 100.24 | 10.60 | 19 | 55738 | 0 | 29518770 |
Unevaluable event | 98.84 | 10.60 | 191 | 55566 | 29660 | 29489110 |
Ventricular fibrillation | 98.68 | 10.60 | 135 | 55622 | 15698 | 29503072 |
Needle issue | 92.19 | 10.60 | 74 | 55683 | 4609 | 29514161 |
Infusion site swelling | 91.49 | 10.60 | 52 | 55705 | 1818 | 29516952 |
Electrocardiogram ST segment elevation | 90.61 | 10.60 | 72 | 55685 | 4420 | 29514350 |
Lagophthalmos | 87.69 | 10.60 | 23 | 55734 | 77 | 29518693 |
Bradycardia | 87.06 | 10.60 | 297 | 55460 | 65332 | 29453438 |
Infusion site pain | 86.38 | 10.60 | 59 | 55698 | 2866 | 29515904 |
Local anaesthetic systemic toxicity | 85.10 | 10.60 | 26 | 55731 | 169 | 29518601 |
Accidental exposure to product by child | 83.84 | 10.60 | 44 | 55713 | 1310 | 29517460 |
Drug ineffective for unapproved indication | 76.48 | 10.60 | 113 | 55644 | 14101 | 29504669 |
Product quality issue | 75.14 | 10.60 | 119 | 55638 | 15776 | 29502994 |
Bronchospasm | 74.04 | 10.60 | 91 | 55666 | 9518 | 29509252 |
Injection site laceration | 73.35 | 10.60 | 16 | 55741 | 16 | 29518754 |
Expired product administered | 72.07 | 10.60 | 52 | 55705 | 2759 | 29516011 |
Device use issue | 67.07 | 10.60 | 23 | 55734 | 225 | 29518545 |
Diarrhoea | 66.89 | 10.60 | 362 | 55395 | 332336 | 29186434 |
Injury associated with device | 65.39 | 10.60 | 32 | 55725 | 819 | 29517951 |
Tachycardia | 65.23 | 10.60 | 290 | 55467 | 72120 | 29446650 |
Upper respiratory tract infection | 65.07 | 10.60 | 153 | 55604 | 27196 | 29491574 |
Arteriospasm coronary | 62.47 | 10.60 | 46 | 55711 | 2519 | 29516251 |
Stress | 59.83 | 10.60 | 128 | 55629 | 21362 | 29497408 |
Incorrect route of product administration | 58.30 | 10.60 | 86 | 55671 | 10715 | 29508055 |
Infusion site extravasation | 56.48 | 10.60 | 47 | 55710 | 3080 | 29515690 |
Pain | 54.24 | 10.60 | 527 | 55230 | 170905 | 29347865 |
Vasoplegia syndrome | 53.22 | 10.60 | 34 | 55723 | 1474 | 29517296 |
Hypoxic-ischaemic encephalopathy | 52.93 | 10.60 | 52 | 55705 | 4232 | 29514538 |
Completed suicide | 52.03 | 10.60 | 56 | 55701 | 90190 | 29428580 |
Endophthalmitis | 51.84 | 10.60 | 43 | 55714 | 2805 | 29515965 |
Sinus tachycardia | 51.80 | 10.60 | 98 | 55659 | 14971 | 29503799 |
General physical health deterioration | 51.72 | 10.60 | 71 | 55686 | 102786 | 29415984 |
Injection site injury | 51.36 | 10.60 | 18 | 55739 | 189 | 29518581 |
Shock | 51.19 | 10.60 | 120 | 55637 | 21284 | 29497486 |
Unresponsive to stimuli | 50.71 | 10.60 | 132 | 55625 | 24994 | 29493776 |
Pulse absent | 48.71 | 10.60 | 54 | 55703 | 5059 | 29513711 |
Kounis syndrome | 47.27 | 10.60 | 34 | 55723 | 1795 | 29516975 |
Metabolic acidosis | 46.91 | 10.60 | 167 | 55590 | 37495 | 29481275 |
Electrocardiogram QRS complex prolonged | 43.69 | 10.60 | 46 | 55711 | 4064 | 29514706 |
Decreased appetite | 43.62 | 10.60 | 135 | 55622 | 145207 | 29373563 |
Wrong product administered | 43.41 | 10.60 | 48 | 55709 | 4483 | 29514287 |
Infusion site erythema | 43.16 | 10.60 | 31 | 55726 | 1633 | 29517137 |
Interstitial lung disease | 41.53 | 10.60 | 29 | 55728 | 57689 | 29461081 |
Anxiety | 40.68 | 10.60 | 288 | 55469 | 85077 | 29433693 |
Anaemia | 40.61 | 10.60 | 218 | 55539 | 200733 | 29318037 |
Multiple organ dysfunction syndrome | 40.02 | 10.60 | 229 | 55528 | 62887 | 29455883 |
Cardiogenic shock | 39.94 | 10.60 | 102 | 55655 | 19088 | 29499682 |
Haemodynamic instability | 38.92 | 10.60 | 61 | 55696 | 8012 | 29510758 |
Infusion site pruritus | 38.27 | 10.60 | 19 | 55738 | 502 | 29518268 |
Accidental overdose | 38.17 | 10.60 | 95 | 55662 | 17498 | 29501272 |
Mydriasis | 38.08 | 10.60 | 52 | 55705 | 6033 | 29512737 |
Administration site pain | 37.75 | 10.60 | 14 | 55743 | 175 | 29518595 |
Anaesthetic complication neurological | 36.81 | 10.60 | 16 | 55741 | 309 | 29518461 |
Post procedural complication | 36.25 | 10.60 | 68 | 55689 | 10321 | 29508449 |
Corneal reflex decreased | 35.53 | 10.60 | 13 | 55744 | 156 | 29518614 |
Cardiotoxicity | 35.06 | 10.60 | 44 | 55713 | 4700 | 29514070 |
Ventricular extrasystoles | 34.14 | 10.60 | 67 | 55690 | 10515 | 29508255 |
Drug intolerance | 33.89 | 10.60 | 25 | 55732 | 48354 | 29470416 |
Injection site coldness | 33.79 | 10.60 | 8 | 55749 | 15 | 29518755 |
Urticaria | 33.78 | 10.60 | 197 | 55560 | 54463 | 29464307 |
Disease progression | 33.26 | 10.60 | 65 | 55692 | 81851 | 29436919 |
Procedural haemorrhage | 32.56 | 10.60 | 30 | 55727 | 2253 | 29516517 |
Weight decreased | 32.55 | 10.60 | 160 | 55597 | 150745 | 29368025 |
Delayed recovery from anaesthesia | 32.43 | 10.60 | 19 | 55738 | 704 | 29518066 |
Generalised tonic-clonic seizure | 32.12 | 10.60 | 94 | 55663 | 19045 | 29499725 |
Apnoea | 32.08 | 10.60 | 48 | 55709 | 6054 | 29512716 |
Infusion site rash | 31.96 | 10.60 | 15 | 55742 | 349 | 29518421 |
Medical device site laceration | 31.65 | 10.60 | 6 | 55751 | 0 | 29518770 |
Eyelid rash | 31.16 | 10.60 | 8 | 55749 | 24 | 29518746 |
Infusion site nodule | 30.83 | 10.60 | 10 | 55747 | 81 | 29518689 |
Cauda equina syndrome | 30.72 | 10.60 | 15 | 55742 | 382 | 29518388 |
Respiratory depression | 30.37 | 10.60 | 74 | 55683 | 13449 | 29505321 |
Mean arterial pressure decreased | 30.07 | 10.60 | 11 | 55746 | 132 | 29518638 |
Removal of foreign body | 29.61 | 10.60 | 7 | 55750 | 13 | 29518757 |
Overdose | 29.02 | 10.60 | 253 | 55504 | 79566 | 29439204 |
Oculocardiac reflex | 29.01 | 10.60 | 9 | 55748 | 62 | 29518708 |
Asthenia | 28.92 | 10.60 | 263 | 55494 | 214987 | 29303783 |
Hypoxia | 28.78 | 10.60 | 170 | 55587 | 47209 | 29471561 |
Injection site hypoaesthesia | 28.41 | 10.60 | 9 | 55748 | 67 | 29518703 |
Neutropenia | 28.19 | 10.60 | 140 | 55617 | 131571 | 29387199 |
Leukopenia | 27.83 | 10.60 | 38 | 55719 | 55165 | 29463605 |
Brain oedema | 27.58 | 10.60 | 67 | 55690 | 12153 | 29506617 |
Blood pressure decreased | 27.51 | 10.60 | 163 | 55594 | 45314 | 29473456 |
Pulseless electrical activity | 27.46 | 10.60 | 46 | 55711 | 6388 | 29512382 |
Thrombocytopenia | 27.34 | 10.60 | 146 | 55611 | 134677 | 29384093 |
Infusion related reaction | 27.00 | 10.60 | 158 | 55599 | 43728 | 29475042 |
Laryngeal oedema | 27 | 10.60 | 31 | 55726 | 3017 | 29515753 |
Acute kidney injury | 26.86 | 10.60 | 346 | 55411 | 264921 | 29253849 |
Cyanosis | 26.75 | 10.60 | 63 | 55694 | 11204 | 29507566 |
Corneal oedema | 26.73 | 10.60 | 20 | 55737 | 1122 | 29517648 |
Hyperthermia malignant | 26.53 | 10.60 | 24 | 55733 | 1760 | 29517010 |
Device malfunction | 26.40 | 10.60 | 53 | 55704 | 8454 | 29510316 |
Incorrect drug administration rate | 26.21 | 10.60 | 20 | 55737 | 1156 | 29517614 |
Spinal cord infarction | 26.10 | 10.60 | 12 | 55745 | 266 | 29518504 |
Circulatory collapse | 26.04 | 10.60 | 86 | 55671 | 18587 | 29500183 |
Electrocardiogram ST segment depression | 26.03 | 10.60 | 26 | 55731 | 2159 | 29516611 |
Systolic anterior motion of mitral valve | 25.92 | 10.60 | 7 | 55750 | 27 | 29518743 |
Malignant neoplasm progression | 25.55 | 10.60 | 64 | 55693 | 73795 | 29444975 |
Angioedema | 25.15 | 10.60 | 123 | 55634 | 31792 | 29486978 |
Death | 24.93 | 10.60 | 475 | 55282 | 341609 | 29177161 |
Melaena | 24.71 | 10.60 | 14 | 55743 | 31162 | 29487608 |
White blood cell count decreased | 24.57 | 10.60 | 78 | 55679 | 83284 | 29435486 |
Toxicity to various agents | 24.32 | 10.60 | 461 | 55296 | 173200 | 29345570 |
Trigemino-cardiac reflex | 24.23 | 10.60 | 10 | 55747 | 169 | 29518601 |
Administration site swelling | 23.96 | 10.60 | 10 | 55747 | 174 | 29518596 |
Hypopyon | 23.73 | 10.60 | 12 | 55745 | 330 | 29518440 |
Loss of consciousness | 23.51 | 10.60 | 228 | 55529 | 73828 | 29444942 |
Psoriasis | 23.43 | 10.60 | 16 | 55741 | 32211 | 29486559 |
Injection site pain | 23.43 | 10.60 | 122 | 55635 | 32324 | 29486446 |
Oedema peripheral | 23.36 | 10.60 | 108 | 55649 | 103449 | 29415321 |
Tryptase increased | 23.16 | 10.60 | 10 | 55747 | 190 | 29518580 |
Hyponatraemia | 23.08 | 10.60 | 59 | 55698 | 67574 | 29451196 |
Cardiac failure congestive | 23.03 | 10.60 | 71 | 55686 | 76510 | 29442260 |
Embolia cutis medicamentosa | 23.01 | 10.60 | 10 | 55747 | 193 | 29518577 |
Respiratory arrest | 22.88 | 10.60 | 103 | 55654 | 25730 | 29493040 |
Haemoglobin decreased | 22.72 | 10.60 | 116 | 55641 | 108259 | 29410511 |
Anal sphincter atony | 22.66 | 10.60 | 8 | 55749 | 86 | 29518684 |
Infusion site bruising | 22.27 | 10.60 | 12 | 55745 | 377 | 29518393 |
Rheumatoid arthritis | 22.02 | 10.60 | 17 | 55740 | 32135 | 29486635 |
Eye infection | 21.72 | 10.60 | 27 | 55730 | 2856 | 29515914 |
Coronary artery disease | 21.69 | 10.60 | 31 | 55726 | 44159 | 29474611 |
Pulmonary oedema | 21.40 | 10.60 | 146 | 55611 | 42589 | 29476181 |
Platelet count decreased | 21.40 | 10.60 | 113 | 55644 | 104559 | 29414211 |
Pancytopenia | 21.05 | 10.60 | 83 | 55674 | 83085 | 29435685 |
Skin texture abnormal | 20.96 | 10.60 | 6 | 55751 | 30 | 29518740 |
Liquid product physical issue | 20.76 | 10.60 | 11 | 55746 | 334 | 29518436 |
Hyperdynamic left ventricle | 20.56 | 10.60 | 8 | 55749 | 115 | 29518655 |
Atrioventricular block complete | 20.34 | 10.60 | 46 | 55711 | 7965 | 29510805 |
Neuromuscular block prolonged | 20.32 | 10.60 | 12 | 55745 | 451 | 29518319 |
Injection site discolouration | 20.26 | 10.60 | 18 | 55739 | 1289 | 29517481 |
Dehydration | 20.19 | 10.60 | 130 | 55627 | 114618 | 29404152 |
Administration site erythema | 20.10 | 10.60 | 7 | 55750 | 72 | 29518698 |
Nasopharyngitis | 20.08 | 10.60 | 186 | 55571 | 59479 | 29459291 |
Infusion site haemorrhage | 20.03 | 10.60 | 14 | 55743 | 706 | 29518064 |
Chondromalacia | 20.00 | 10.60 | 5 | 55752 | 13 | 29518757 |
Hypoglycaemia | 19.93 | 10.60 | 38 | 55719 | 48308 | 29470462 |
Respiratory acidosis | 19.89 | 10.60 | 32 | 55725 | 4296 | 29514474 |
Pupil fixed | 19.87 | 10.60 | 20 | 55737 | 1676 | 29517094 |
Familial periodic paralysis | 19.76 | 10.60 | 7 | 55750 | 76 | 29518694 |
Macroglossia | 19.74 | 10.60 | 11 | 55746 | 370 | 29518400 |
Left ventricle outflow tract obstruction | 19.72 | 10.60 | 8 | 55749 | 129 | 29518641 |
Aqueous fibrin | 19.64 | 10.60 | 6 | 55751 | 39 | 29518731 |
Anterior chamber cell | 19.61 | 10.60 | 10 | 55747 | 280 | 29518490 |
Procedural hypotension | 19.54 | 10.60 | 15 | 55742 | 875 | 29517895 |
Diabetes mellitus | 19.49 | 10.60 | 28 | 55729 | 39803 | 29478967 |
Agranulocytosis | 19.45 | 10.60 | 7 | 55750 | 20333 | 29498437 |
Hypersensitivity | 19.38 | 10.60 | 168 | 55589 | 52735 | 29466035 |
COVID-19 immunisation | 19.34 | 10.60 | 8 | 55749 | 136 | 29518634 |
Hepatocellular injury | 19.17 | 10.60 | 8 | 55749 | 21235 | 29497535 |
Intracranial hypotension | 19.15 | 10.60 | 9 | 55748 | 210 | 29518560 |
Headache | 18.86 | 10.60 | 445 | 55312 | 173562 | 29345208 |
Tubulointerstitial nephritis | 18.80 | 10.60 | 5 | 55752 | 17638 | 29501132 |
Retinal artery occlusion | 18.76 | 10.60 | 19 | 55738 | 1604 | 29517166 |
Eyelid oedema | 18.28 | 10.60 | 32 | 55725 | 4604 | 29514166 |
Ophthalmoplegia | 18.19 | 10.60 | 19 | 55738 | 1663 | 29517107 |
International normalised ratio increased | 18.18 | 10.60 | 35 | 55722 | 44337 | 29474433 |
Vitritis | 18.18 | 10.60 | 13 | 55744 | 680 | 29518090 |
Malaise | 18.09 | 10.60 | 203 | 55554 | 159399 | 29359371 |
COVID-19 | 18.01 | 10.60 | 123 | 55634 | 35891 | 29482879 |
Phaeochromocytoma crisis | 17.75 | 10.60 | 6 | 55751 | 56 | 29518714 |
Procedural complication | 17.29 | 10.60 | 29 | 55728 | 4031 | 29514739 |
Cardiac arrest neonatal | 17.15 | 10.60 | 5 | 55752 | 27 | 29518743 |
Reperfusion arrhythmia | 17.12 | 10.60 | 6 | 55751 | 63 | 29518707 |
Coma | 17.00 | 10.60 | 130 | 55627 | 39320 | 29479450 |
Croup infectious | 16.87 | 10.60 | 9 | 55748 | 277 | 29518493 |
Dry gangrene | 16.81 | 10.60 | 10 | 55747 | 381 | 29518389 |
Product adhesion issue | 16.60 | 10.60 | 17 | 55740 | 1454 | 29517316 |
Dyspnoea exertional | 16.56 | 10.60 | 27 | 55730 | 36463 | 29482307 |
Blindness | 16.43 | 10.60 | 55 | 55702 | 11968 | 29506802 |
Paraplegia | 16.38 | 10.60 | 22 | 55735 | 2512 | 29516258 |
Cytomegalovirus infection | 16.25 | 10.60 | 12 | 55745 | 23203 | 29495567 |
Myalgia | 16.21 | 10.60 | 78 | 55679 | 73941 | 29444829 |
Catecholamine crisis | 16.17 | 10.60 | 5 | 55752 | 34 | 29518736 |
Administration site irritation | 16.11 | 10.60 | 4 | 55753 | 10 | 29518760 |
Jaundice | 15.97 | 10.60 | 19 | 55738 | 29277 | 29489493 |
Administration site scar | 15.83 | 10.60 | 3 | 55754 | 0 | 29518770 |
Retinal vasculitis | 15.82 | 10.60 | 9 | 55748 | 315 | 29518455 |
Myopathy toxic | 15.79 | 10.60 | 10 | 55747 | 427 | 29518343 |
Hepatotoxicity | 15.69 | 10.60 | 7 | 55750 | 17860 | 29500910 |
Blood pressure fluctuation | 15.67 | 10.60 | 9 | 55748 | 19885 | 29498885 |
Vitreous floaters | 15.63 | 10.60 | 24 | 55733 | 3097 | 29515673 |
Gastrointestinal haemorrhage | 15.62 | 10.60 | 87 | 55670 | 79446 | 29439324 |
Injection site extravasation | 15.54 | 10.60 | 21 | 55736 | 2412 | 29516358 |
Recalled product administered | 15.48 | 10.60 | 10 | 55747 | 442 | 29518328 |
Myocardial stunning | 15.34 | 10.60 | 4 | 55753 | 13 | 29518757 |
Pancreatitis acute | 15.34 | 10.60 | 14 | 55743 | 24371 | 29494399 |
Anion gap | 15.28 | 10.60 | 12 | 55745 | 724 | 29518046 |
Vitreous disorder | 15.25 | 10.60 | 6 | 55751 | 89 | 29518681 |
Pallor | 15.14 | 10.60 | 79 | 55678 | 20945 | 29497825 |
Injury corneal | 15.11 | 10.60 | 4 | 55753 | 14 | 29518756 |
Sinus arrest | 15.03 | 10.60 | 16 | 55741 | 1431 | 29517339 |
Abdominal pain | 15.00 | 10.60 | 173 | 55584 | 135184 | 29383586 |
Areflexia | 14.96 | 10.60 | 22 | 55735 | 2732 | 29516038 |
Accelerated idioventricular rhythm | 14.95 | 10.60 | 6 | 55751 | 94 | 29518676 |
Infusion site mass | 14.86 | 10.60 | 8 | 55749 | 251 | 29518519 |
Fatigue | 14.80 | 10.60 | 470 | 55287 | 316351 | 29202419 |
Electrocardiogram T wave amplitude increased | 14.66 | 10.60 | 5 | 55752 | 48 | 29518722 |
Factor V Leiden mutation | 14.66 | 10.60 | 5 | 55752 | 48 | 29518722 |
Haematochezia | 14.44 | 10.60 | 30 | 55727 | 36953 | 29481817 |
Corneal opacity | 14.33 | 10.60 | 10 | 55747 | 503 | 29518267 |
Asthma | 14.28 | 10.60 | 111 | 55646 | 33738 | 29485032 |
Angina pectoris | 14.20 | 10.60 | 19 | 55738 | 27831 | 29490939 |
Food allergy | 14.18 | 10.60 | 13 | 55744 | 970 | 29517800 |
Tracheitis | 14.17 | 10.60 | 11 | 55746 | 652 | 29518118 |
Foreign body | 14.10 | 10.60 | 13 | 55744 | 977 | 29517793 |
Gait disturbance | 13.99 | 10.60 | 81 | 55676 | 73268 | 29445502 |
Respiratory distress | 13.94 | 10.60 | 106 | 55651 | 32000 | 29486770 |
Skin infection | 13.90 | 10.60 | 35 | 55722 | 6492 | 29512278 |
Transient ischaemic attack | 13.89 | 10.60 | 14 | 55743 | 23256 | 29495514 |
Pulmonary fibrosis | 13.85 | 10.60 | 6 | 55751 | 15576 | 29503194 |
Administration site pruritus | 13.81 | 10.60 | 4 | 55753 | 21 | 29518749 |
General anaesthesia | 13.75 | 10.60 | 3 | 55754 | 3 | 29518767 |
Electrocardiogram ST-T segment depression | 13.75 | 10.60 | 3 | 55754 | 3 | 29518767 |
End-tidal CO2 decreased | 13.75 | 10.60 | 3 | 55754 | 3 | 29518767 |
Pupillary reflex impaired | 13.62 | 10.60 | 15 | 55742 | 1394 | 29517376 |
Infusion site irritation | 13.60 | 10.60 | 7 | 55750 | 200 | 29518570 |
Oxygen saturation decreased | 13.59 | 10.60 | 137 | 55620 | 44800 | 29473970 |
Rectal haemorrhage | 13.51 | 10.60 | 28 | 55729 | 34521 | 29484249 |
Ventricular arrhythmia | 13.48 | 10.60 | 28 | 55729 | 4576 | 29514194 |
Administration site reaction | 13.45 | 10.60 | 5 | 55752 | 63 | 29518707 |
Blood lactic acid increased | 13.42 | 10.60 | 32 | 55725 | 5734 | 29513036 |
Gas gangrene | 13.38 | 10.60 | 5 | 55752 | 64 | 29518706 |
Paralysis | 13.33 | 10.60 | 31 | 55726 | 5466 | 29513304 |
Seizure | 13.28 | 10.60 | 248 | 55509 | 92875 | 29425895 |
Injection site joint infection | 13.23 | 10.60 | 4 | 55753 | 25 | 29518745 |
Infusion site reaction | 13.06 | 10.60 | 11 | 55746 | 733 | 29518037 |
Suicide attempt | 13.04 | 10.60 | 28 | 55729 | 34082 | 29484688 |
Throat tightness | 13.04 | 10.60 | 36 | 55721 | 7055 | 29511715 |
Cholestasis | 13.02 | 10.60 | 15 | 55742 | 23447 | 29495323 |
Drug-induced liver injury | 12.96 | 10.60 | 13 | 55744 | 21642 | 29497128 |
Visual acuity reduced | 12.93 | 10.60 | 59 | 55698 | 14817 | 29503953 |
Intestinal haematoma | 12.91 | 10.60 | 5 | 55752 | 71 | 29518699 |
Deep vein thrombosis | 12.85 | 10.60 | 60 | 55697 | 57339 | 29461431 |
Retinal vascular occlusion | 12.85 | 10.60 | 6 | 55751 | 138 | 29518632 |
Medication error | 12.80 | 10.60 | 76 | 55681 | 21135 | 29497635 |
Product administered at inappropriate site | 12.78 | 10.60 | 16 | 55741 | 1704 | 29517066 |
Nodal rhythm | 12.67 | 10.60 | 14 | 55743 | 1306 | 29517464 |
Seizure like phenomena | 12.55 | 10.60 | 10 | 55747 | 616 | 29518154 |
Optic nerve injury | 12.54 | 10.60 | 5 | 55752 | 77 | 29518693 |
Haematuria | 12.51 | 10.60 | 42 | 55715 | 44097 | 29474673 |
Compartment syndrome | 12.48 | 10.60 | 19 | 55738 | 2433 | 29516337 |
Administration related reaction | 12.25 | 10.60 | 5 | 55752 | 82 | 29518688 |
Anaphylactoid shock | 12.22 | 10.60 | 8 | 55749 | 362 | 29518408 |
Myocardial infarction | 12.20 | 10.60 | 141 | 55616 | 110155 | 29408615 |
Burkholderia test positive | 12.11 | 10.60 | 12 | 55745 | 987 | 29517783 |
Sleep disorder | 12.07 | 10.60 | 17 | 55740 | 24369 | 29494401 |
Myelosuppression | 12.05 | 10.60 | 4 | 55753 | 12223 | 29506547 |
Myokymia | 11.98 | 10.60 | 5 | 55752 | 87 | 29518683 |
Laryngeal stenosis | 11.98 | 10.60 | 5 | 55752 | 87 | 29518683 |
Heart rate increased | 11.91 | 10.60 | 119 | 55638 | 38819 | 29479951 |
Oral lichen planus | 11.87 | 10.60 | 6 | 55751 | 165 | 29518605 |
Hepatitis | 11.85 | 10.60 | 13 | 55744 | 20770 | 29498000 |
Drug resistance | 11.71 | 10.60 | 14 | 55743 | 21526 | 29497244 |
Apgar score low | 11.69 | 10.60 | 11 | 55746 | 848 | 29517922 |
Expired device used | 11.68 | 10.60 | 4 | 55753 | 39 | 29518731 |
Brain stem syndrome | 11.52 | 10.60 | 8 | 55749 | 399 | 29518371 |
Pharyngeal oedema | 11.43 | 10.60 | 30 | 55727 | 5704 | 29513066 |
Eosinophilia | 11.42 | 10.60 | 15 | 55742 | 22146 | 29496624 |
Eye inflammation | 11.38 | 10.60 | 15 | 55742 | 1681 | 29517089 |
Fall | 11.36 | 10.60 | 251 | 55506 | 176927 | 29341843 |
Status asthmaticus | 11.35 | 10.60 | 7 | 55750 | 285 | 29518485 |
Pneumocystis jirovecii pneumonia | 11.33 | 10.60 | 9 | 55748 | 16770 | 29502000 |
Oesophageal obstruction | 11.28 | 10.60 | 8 | 55749 | 413 | 29518357 |
Spinal cord oedema | 11.27 | 10.60 | 6 | 55751 | 184 | 29518586 |
Insomnia | 11.22 | 10.60 | 110 | 55647 | 88651 | 29430119 |
Extrasystoles | 11.21 | 10.60 | 22 | 55735 | 3452 | 29515318 |
Musculoskeletal stiffness | 11.06 | 10.60 | 35 | 55722 | 37423 | 29481347 |
Cardiac failure | 11.00 | 10.60 | 96 | 55661 | 79191 | 29439579 |
Device issue | 11.00 | 10.60 | 36 | 55721 | 7744 | 29511026 |
Orthostatic hypotension | 10.98 | 10.60 | 16 | 55741 | 22613 | 29496157 |
Quadriplegia | 10.96 | 10.60 | 14 | 55743 | 1522 | 29517248 |
Neuromuscular blockade | 10.95 | 10.60 | 6 | 55751 | 195 | 29518575 |
Drug interaction | 10.91 | 10.60 | 286 | 55471 | 197099 | 29321671 |
Tonic convulsion | 10.90 | 10.60 | 11 | 55746 | 925 | 29517845 |
Liver function test abnormal | 10.84 | 10.60 | 24 | 55733 | 28894 | 29489876 |
Penile vascular disorder | 10.83 | 10.60 | 3 | 55754 | 13 | 29518757 |
Alopecia | 10.81 | 10.60 | 12 | 55745 | 19072 | 29499698 |
Respiratory tract infection | 10.71 | 10.60 | 58 | 55699 | 15593 | 29503177 |
Posterior capsule rupture | 10.65 | 10.60 | 3 | 55754 | 14 | 29518756 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic reaction | 602.93 | 9.45 | 699 | 122534 | 67965 | 64307534 |
Stress cardiomyopathy | 541.94 | 9.45 | 291 | 122942 | 8966 | 64366533 |
Toxic anterior segment syndrome | 504.53 | 9.45 | 186 | 123047 | 2253 | 64373246 |
Anaesthetic complication | 490.78 | 9.45 | 185 | 123048 | 2394 | 64373105 |
Cardiac arrest | 450.98 | 9.45 | 943 | 122290 | 153121 | 64222378 |
Local anaesthetic systemic toxicity | 401.08 | 9.45 | 115 | 123118 | 570 | 64374929 |
Anaphylactic shock | 396.79 | 9.45 | 382 | 122851 | 29946 | 64345553 |
Hereditary angioedema | 354.62 | 9.45 | 165 | 123068 | 3711 | 64371788 |
Device failure | 341.78 | 9.45 | 182 | 123051 | 5510 | 64369989 |
Chondrolysis | 296.83 | 9.45 | 78 | 123155 | 259 | 64375240 |
Hypotension | 235.63 | 9.45 | 1385 | 121848 | 379589 | 63995910 |
Drug ineffective | 228.76 | 9.45 | 2528 | 120705 | 837719 | 63537780 |
Fear | 228.55 | 9.45 | 235 | 122998 | 19936 | 64355563 |
Ventricular tachycardia | 225.41 | 9.45 | 302 | 122931 | 33963 | 64341536 |
Lagophthalmos | 223.34 | 9.45 | 63 | 123170 | 291 | 64375208 |
Renal injury | 204.90 | 9.45 | 196 | 123037 | 15233 | 64360266 |
Completed suicide | 185.10 | 9.45 | 99 | 123134 | 224315 | 64151184 |
Bradycardia | 183.98 | 9.45 | 570 | 122663 | 117649 | 64257850 |
Incorrect route of product administration | 182.59 | 9.45 | 224 | 123009 | 23074 | 64352425 |
Anhedonia | 176.14 | 9.45 | 171 | 123062 | 13535 | 64361964 |
Sinusitis | 168.64 | 9.45 | 637 | 122596 | 145291 | 64230208 |
Injury | 166.17 | 9.45 | 345 | 122888 | 55647 | 64319852 |
Ventricular fibrillation | 164.17 | 9.45 | 215 | 123018 | 23645 | 64351854 |
Pulseless electrical activity | 163.83 | 9.45 | 159 | 123074 | 12580 | 64362919 |
Bronchospasm | 159.57 | 9.45 | 202 | 123031 | 21480 | 64354019 |
Kounis syndrome | 157.43 | 9.45 | 88 | 123145 | 2937 | 64372562 |
Unevaluable event | 149.71 | 9.45 | 311 | 122922 | 50178 | 64325321 |
Emotional distress | 147.86 | 9.45 | 255 | 122978 | 35783 | 64339716 |
Methaemoglobinaemia | 144.83 | 9.45 | 95 | 123138 | 4253 | 64371246 |
Drug intolerance | 143.54 | 9.45 | 91 | 123142 | 187901 | 64187598 |
Accidental exposure to product | 143.16 | 9.45 | 212 | 123021 | 26152 | 64349347 |
Product quality issue | 135.78 | 9.45 | 221 | 123012 | 29578 | 64345921 |
Shock | 130.73 | 9.45 | 250 | 122983 | 37990 | 64337509 |
Electrocardiogram ST segment elevation | 129.63 | 9.45 | 109 | 123124 | 7150 | 64368349 |
Tachycardia | 123.84 | 9.45 | 590 | 122643 | 148989 | 64226510 |
Joint swelling | 123.04 | 9.45 | 138 | 123095 | 215244 | 64160255 |
Corneal oedema | 118.78 | 9.45 | 67 | 123166 | 2276 | 64373223 |
Arteriospasm coronary | 118.66 | 9.45 | 92 | 123141 | 5373 | 64370126 |
Contraindicated product administered | 118.34 | 9.45 | 30 | 123203 | 107799 | 64267700 |
Endophthalmitis | 113.63 | 9.45 | 89 | 123144 | 5276 | 64370223 |
General physical health deterioration | 113.50 | 9.45 | 134 | 123099 | 204291 | 64171208 |
Cardiogenic shock | 112.08 | 9.45 | 213 | 123020 | 32214 | 64343285 |
Urticaria | 110.49 | 9.45 | 565 | 122668 | 146752 | 64228747 |
Injection site pallor | 107.75 | 9.45 | 25 | 123208 | 40 | 64375459 |
Synovitis | 106.02 | 9.45 | 29 | 123204 | 99061 | 64276438 |
Left ventricle outflow tract obstruction | 103.35 | 9.45 | 34 | 123199 | 285 | 64375214 |
Diarrhoea | 101.80 | 9.45 | 888 | 122345 | 721816 | 63653683 |
Rheumatoid arthritis | 99.70 | 9.45 | 100 | 123133 | 164194 | 64211305 |
Pulse absent | 99.12 | 9.45 | 103 | 123130 | 8843 | 64366656 |
Cauda equina syndrome | 97.94 | 9.45 | 46 | 123187 | 1057 | 64374442 |
Hand deformity | 96.01 | 9.45 | 6 | 123227 | 62765 | 64312734 |
Unresponsive to stimuli | 94.68 | 9.45 | 260 | 122973 | 50133 | 64325366 |
Haemodynamic instability | 92.84 | 9.45 | 128 | 123105 | 14784 | 64360715 |
Sinus tachycardia | 92.75 | 9.45 | 196 | 123037 | 31992 | 64343507 |
Pemphigus | 92.26 | 9.45 | 6 | 123227 | 60695 | 64314804 |
Hepatic enzyme increased | 86.04 | 9.45 | 73 | 123160 | 129870 | 64245629 |
Generalised tonic-clonic seizure | 85.42 | 9.45 | 216 | 123017 | 39641 | 64335858 |
Drug ineffective for unapproved indication | 84.46 | 9.45 | 185 | 123048 | 30948 | 64344551 |
Infusion site swelling | 81.37 | 9.45 | 74 | 123159 | 5391 | 64370108 |
Wrong product administered | 80.40 | 9.45 | 86 | 123147 | 7634 | 64367865 |
Vasoplegia syndrome | 79.11 | 9.45 | 55 | 123178 | 2712 | 64372787 |
Injection site ischaemia | 78.40 | 9.45 | 16 | 123217 | 7 | 64375492 |
Injury associated with device | 77.60 | 9.45 | 55 | 123178 | 2798 | 64372701 |
Arthralgia | 77.44 | 9.45 | 511 | 122722 | 441749 | 63933750 |
Stridor | 76.52 | 9.45 | 68 | 123165 | 4806 | 64370693 |
Hypopyon | 76.51 | 9.45 | 38 | 123195 | 991 | 64374508 |
Pulmonary oedema | 74.50 | 9.45 | 323 | 122910 | 78351 | 64297148 |
Expired product administered | 73.76 | 9.45 | 73 | 123160 | 5914 | 64369585 |
Pericarditis | 73.37 | 9.45 | 15 | 123218 | 62501 | 64312998 |
Maternal exposure during delivery | 72.56 | 9.45 | 35 | 123198 | 855 | 64374644 |
Accidental exposure to product by child | 72.47 | 9.45 | 50 | 123183 | 2435 | 64373064 |
Infusion site erythema | 72.34 | 9.45 | 77 | 123156 | 6796 | 64368703 |
Systemic lupus erythematosus | 72.02 | 9.45 | 29 | 123204 | 77583 | 64297916 |
Anaesthetic complication neurological | 68.52 | 9.45 | 29 | 123204 | 516 | 64374983 |
Electrocardiogram ST segment depression | 68.44 | 9.45 | 61 | 123172 | 4328 | 64371171 |
Anxiety | 68.08 | 9.45 | 638 | 122595 | 202011 | 64173488 |
Glossodynia | 67.23 | 9.45 | 20 | 123213 | 64676 | 64310823 |
Needle issue | 66.03 | 9.45 | 85 | 123148 | 9187 | 64366312 |
Stress | 63.94 | 9.45 | 257 | 122976 | 60277 | 64315222 |
Tryptase increased | 62.84 | 9.45 | 26 | 123207 | 436 | 64375063 |
Infusion site extravasation | 62.27 | 9.45 | 71 | 123162 | 6766 | 64368733 |
Post procedural complication | 61.49 | 9.45 | 130 | 123103 | 21223 | 64354276 |
Hyponatraemia | 61.26 | 9.45 | 119 | 123114 | 148220 | 64227279 |
Arthropathy | 61.18 | 9.45 | 85 | 123148 | 120882 | 64254617 |
Mydriasis | 61.03 | 9.45 | 107 | 123126 | 15205 | 64360294 |
Decreased appetite | 60.45 | 9.45 | 304 | 122929 | 280985 | 64094514 |
Eyelid rash | 60.01 | 9.45 | 17 | 123216 | 80 | 64375419 |
Airway peak pressure increased | 59.89 | 9.45 | 23 | 123210 | 314 | 64375185 |
Alopecia | 59.26 | 9.45 | 144 | 123089 | 165546 | 64209953 |
Upper respiratory tract infection | 58.65 | 9.45 | 285 | 122948 | 72500 | 64302999 |
Asthenia | 58.27 | 9.45 | 530 | 122703 | 427514 | 63947985 |
Anaemia | 58.24 | 9.45 | 454 | 122779 | 378226 | 63997273 |
Multiple organ dysfunction syndrome | 58.13 | 9.45 | 362 | 122871 | 101051 | 64274448 |
Abdominal discomfort | 57.97 | 9.45 | 168 | 123065 | 182154 | 64193345 |
Procedural hypotension | 57.49 | 9.45 | 39 | 123194 | 1847 | 64373652 |
Neutropenia | 57.36 | 9.45 | 249 | 122984 | 239375 | 64136124 |
Metabolic acidosis | 57.29 | 9.45 | 278 | 122955 | 70680 | 64304819 |
Injection site injury | 57.19 | 9.45 | 27 | 123206 | 628 | 64374871 |
Cyanosis | 57.11 | 9.45 | 129 | 123104 | 22026 | 64353473 |
Acute kidney injury | 56.58 | 9.45 | 567 | 122666 | 448673 | 63926826 |
Accidental overdose | 56.08 | 9.45 | 166 | 123067 | 33391 | 64342108 |
Circulatory collapse | 55.55 | 9.45 | 166 | 123067 | 33566 | 64341933 |
Helicobacter infection | 54.89 | 9.45 | 5 | 123228 | 38357 | 64337142 |
Extradural abscess | 54.87 | 9.45 | 32 | 123201 | 1159 | 64374340 |
Vitritis | 54.76 | 9.45 | 35 | 123198 | 1498 | 64374001 |
Blood pressure decreased | 53.41 | 9.45 | 314 | 122919 | 85885 | 64289614 |
Cataract operation complication | 53.17 | 9.45 | 20 | 123213 | 257 | 64375242 |
Angioedema | 52.66 | 9.45 | 246 | 122987 | 61575 | 64313924 |
Hypoxic-ischaemic encephalopathy | 51.62 | 9.45 | 66 | 123167 | 7086 | 64368413 |
Anterior chamber cell | 51.31 | 9.45 | 27 | 123206 | 797 | 64374702 |
Injection site laceration | 51.26 | 9.45 | 16 | 123217 | 111 | 64375388 |
Ophthalmoplegia | 51.21 | 9.45 | 42 | 123191 | 2660 | 64372839 |
Seizure | 50.91 | 9.45 | 515 | 122718 | 166377 | 64209122 |
Peripheral ischaemia | 50.78 | 9.45 | 71 | 123162 | 8307 | 64367192 |
Removal of foreign body | 50.01 | 9.45 | 12 | 123221 | 24 | 64375475 |
Body tinea | 49.89 | 9.45 | 31 | 123202 | 1262 | 64374237 |
Electrocardiogram QRS complex prolonged | 49.69 | 9.45 | 74 | 123159 | 9170 | 64366329 |
Injection site coldness | 49.64 | 9.45 | 15 | 123218 | 92 | 64375407 |
Extradural haematoma | 49.47 | 9.45 | 41 | 123192 | 2635 | 64372864 |
Infusion site pruritus | 48.33 | 9.45 | 40 | 123193 | 2566 | 64372933 |
Lower respiratory tract infection | 48.33 | 9.45 | 66 | 123167 | 94548 | 64280951 |
Musculoskeletal stiffness | 47.34 | 9.45 | 103 | 123130 | 123103 | 64252396 |
Infusion site pain | 47.20 | 9.45 | 77 | 123156 | 10320 | 64365179 |
Incorrect drug administration rate | 46.85 | 9.45 | 40 | 123193 | 2679 | 64372820 |
Ventricular extrasystoles | 46.23 | 9.45 | 103 | 123130 | 17426 | 64358073 |
Disease progression | 46.17 | 9.45 | 129 | 123104 | 141551 | 64233948 |
Wound | 45.85 | 9.45 | 47 | 123186 | 76430 | 64299069 |
Apnoea | 45.72 | 9.45 | 76 | 123157 | 10346 | 64365153 |
Impaired quality of life | 45.58 | 9.45 | 59 | 123174 | 6412 | 64369087 |
Therapeutic product effect decreased | 45.51 | 9.45 | 95 | 123138 | 115256 | 64260243 |
Mean arterial pressure decreased | 45.31 | 9.45 | 19 | 123214 | 330 | 64375169 |
Hyperaesthesia | 45.24 | 9.45 | 74 | 123159 | 9940 | 64365559 |
Overdose | 45.17 | 9.45 | 485 | 122748 | 159081 | 64216418 |
Respiratory depression | 45.06 | 9.45 | 122 | 123111 | 23321 | 64352178 |
Loss of consciousness | 44.85 | 9.45 | 457 | 122776 | 147908 | 64227591 |
Respiratory acidosis | 44.76 | 9.45 | 73 | 123160 | 9782 | 64365717 |
Trigemino-cardiac reflex | 44.61 | 9.45 | 17 | 123216 | 227 | 64375272 |
Systolic anterior motion of mitral valve | 44.54 | 9.45 | 12 | 123221 | 45 | 64375454 |
Neuromuscular block prolonged | 44.35 | 9.45 | 26 | 123207 | 951 | 64374548 |
Ear infection | 44.19 | 9.45 | 121 | 123112 | 23283 | 64352216 |
Thrombocytopenia | 44.09 | 9.45 | 249 | 122984 | 223552 | 64151947 |
Intentional self-injury | 43.75 | 9.45 | 3 | 123230 | 29041 | 64346458 |
Swollen tongue | 43.17 | 9.45 | 156 | 123077 | 34798 | 64340701 |
Interstitial lung disease | 42.46 | 9.45 | 76 | 123157 | 97656 | 64277843 |
Leukopenia | 41.98 | 9.45 | 81 | 123152 | 101161 | 64274338 |
Myopathy toxic | 41.97 | 9.45 | 24 | 123209 | 837 | 64374662 |
Status asthmaticus | 41.95 | 9.45 | 25 | 123208 | 943 | 64374556 |
Hypoxia | 41.69 | 9.45 | 300 | 122933 | 87849 | 64287650 |
Ventricular hypokinesia | 41.49 | 9.45 | 62 | 123171 | 7707 | 64367792 |
Retinal artery occlusion | 40.68 | 9.45 | 38 | 123195 | 2865 | 64372634 |
Pharyngeal oedema | 40.66 | 9.45 | 91 | 123142 | 15440 | 64360059 |
Retinal vasculitis | 40.51 | 9.45 | 26 | 123207 | 1121 | 64374378 |
Delayed recovery from anaesthesia | 40.50 | 9.45 | 29 | 123204 | 1499 | 64374000 |
Device use issue | 40.10 | 9.45 | 31 | 123202 | 1802 | 64373697 |
Pancytopenia | 39.97 | 9.45 | 140 | 123093 | 143169 | 64232330 |
Nerve root injury | 39.86 | 9.45 | 10 | 123223 | 26 | 64375473 |
Malignant neoplasm progression | 39.63 | 9.45 | 99 | 123134 | 112772 | 64262727 |
Spinal cord infarction | 39.17 | 9.45 | 20 | 123213 | 554 | 64374945 |
Injection site hypoaesthesia | 39.08 | 9.45 | 18 | 123215 | 395 | 64375104 |
Infusion site mass | 39.07 | 9.45 | 24 | 123209 | 957 | 64374542 |
Procedural haemorrhage | 38.46 | 9.45 | 44 | 123189 | 4208 | 64371291 |
Aqueous fibrin | 38.41 | 9.45 | 13 | 123220 | 120 | 64375379 |
Cholestasis | 38.12 | 9.45 | 19 | 123214 | 44853 | 64330646 |
Paralysis | 37.41 | 9.45 | 74 | 123159 | 11521 | 64363978 |
Procedural complication | 37.40 | 9.45 | 57 | 123176 | 7208 | 64368291 |
Lip swelling | 37.38 | 9.45 | 140 | 123093 | 31767 | 64343732 |
Laryngeal oedema | 36.89 | 9.45 | 56 | 123177 | 7057 | 64368442 |
Medical device site laceration | 36.84 | 9.45 | 7 | 123226 | 0 | 64375499 |
Cardiac failure congestive | 36.80 | 9.45 | 127 | 123106 | 130453 | 64245046 |
Anaphylactoid shock | 36.71 | 9.45 | 21 | 123212 | 733 | 64374766 |
Hypoaesthesia oral | 36.28 | 9.45 | 73 | 123160 | 11507 | 64363992 |
Sleep disorder due to general medical condition, insomnia type | 36.08 | 9.45 | 4 | 123229 | 26266 | 64349233 |
Product adhesion issue | 36.03 | 9.45 | 33 | 123200 | 2426 | 64373073 |
Infusion site bruising | 35.92 | 9.45 | 27 | 123206 | 1505 | 64373994 |
Troponin I increased | 35.34 | 9.45 | 40 | 123193 | 3781 | 64371718 |
Drug reaction with eosinophilia and systemic symptoms | 35.21 | 9.45 | 31 | 123202 | 54186 | 64321313 |
Chondromalacia | 34.99 | 9.45 | 13 | 123220 | 161 | 64375338 |
Paraplegia | 34.90 | 9.45 | 43 | 123190 | 4447 | 64371052 |
Uterine hypertonus | 34.72 | 9.45 | 14 | 123219 | 219 | 64375280 |
Fall | 34.63 | 9.45 | 574 | 122659 | 416252 | 63959247 |
Bronchitis | 34.32 | 9.45 | 338 | 122895 | 108405 | 64267094 |
Agranulocytosis | 34.31 | 9.45 | 15 | 123218 | 38214 | 64337285 |
Gas gangrene | 34.27 | 9.45 | 14 | 123219 | 227 | 64375272 |
Toxicity to various agents | 34.24 | 9.45 | 923 | 122310 | 362590 | 64012909 |
Folliculitis | 33.70 | 9.45 | 8 | 123225 | 30069 | 64345430 |
Cardiotoxicity | 33.67 | 9.45 | 66 | 123167 | 10208 | 64365291 |
Product contamination microbial | 33.64 | 9.45 | 21 | 123212 | 862 | 64374637 |
Anal sphincter atony | 33.39 | 9.45 | 15 | 123218 | 310 | 64375189 |
Bladder prolapse | 33.37 | 9.45 | 23 | 123210 | 1118 | 64374381 |
Paraesthesia oral | 33.33 | 9.45 | 76 | 123157 | 13055 | 64362444 |
COVID-19 | 33.32 | 9.45 | 226 | 123007 | 64914 | 64310585 |
Infection susceptibility increased | 33.14 | 9.45 | 33 | 123200 | 2693 | 64372806 |
Fear of eating | 32.87 | 9.45 | 16 | 123217 | 399 | 64375100 |
Meningitis chemical | 32.86 | 9.45 | 13 | 123220 | 193 | 64375306 |
Fatigue | 32.77 | 9.45 | 1137 | 122096 | 747593 | 63627906 |
Throat tightness | 32.63 | 9.45 | 108 | 123125 | 23052 | 64352447 |
Orthostatic hypotension | 32.49 | 9.45 | 25 | 123208 | 46713 | 64328786 |
Weight decreased | 32.13 | 9.45 | 370 | 122863 | 285369 | 64090130 |
C-reactive protein abnormal | 32.01 | 9.45 | 8 | 123225 | 29039 | 64346460 |
Blood creatinine increased | 31.91 | 9.45 | 142 | 123091 | 135640 | 64239859 |
Muscle injury | 31.74 | 9.45 | 6 | 123227 | 26431 | 64349068 |
Peripheral nerve injury | 31.74 | 9.45 | 18 | 123215 | 618 | 64374881 |
Blood lactic acid increased | 30.73 | 9.45 | 64 | 123169 | 10337 | 64365162 |
Respiratory distress | 30.72 | 9.45 | 188 | 123045 | 52143 | 64323356 |
Type I hypersensitivity | 30.68 | 9.45 | 36 | 123197 | 3538 | 64371961 |
Hepatocellular injury | 30.43 | 9.45 | 25 | 123208 | 45210 | 64330289 |
Visual acuity reduced | 30.08 | 9.45 | 117 | 123116 | 27024 | 64348475 |
Asthma | 30.05 | 9.45 | 296 | 122937 | 94929 | 64280570 |
Anaphylactoid reaction | 29.99 | 9.45 | 41 | 123192 | 4697 | 64370802 |
Myocardial ischaemia | 29.76 | 9.45 | 105 | 123128 | 23146 | 64352353 |
Wheezing | 29.72 | 9.45 | 259 | 122974 | 80320 | 64295179 |
Blindness | 29.54 | 9.45 | 101 | 123132 | 21918 | 64353581 |
Platelet aggregation inhibition | 29.34 | 9.45 | 11 | 123222 | 140 | 64375359 |
Corneal reflex decreased | 29.29 | 9.45 | 14 | 123219 | 335 | 64375164 |
Psoriasis | 29.17 | 9.45 | 58 | 123175 | 71645 | 64303854 |
Electrocardiogram T wave inversion | 28.96 | 9.45 | 41 | 123192 | 4853 | 64370646 |
Oculocardiac reflex | 28.89 | 9.45 | 9 | 123224 | 62 | 64375437 |
Mobility decreased | 28.82 | 9.45 | 77 | 123156 | 85763 | 64289736 |
Melaena | 28.73 | 9.45 | 36 | 123197 | 53512 | 64321987 |
Hyperdynamic left ventricle | 28.53 | 9.45 | 13 | 123220 | 278 | 64375221 |
Sensory loss | 28.23 | 9.45 | 61 | 123172 | 10108 | 64365391 |
Impaired healing | 28.13 | 9.45 | 45 | 123188 | 60428 | 64315071 |
COVID-19 immunisation | 27.80 | 9.45 | 16 | 123217 | 565 | 64374934 |
Blood pH decreased | 27.72 | 9.45 | 38 | 123195 | 4364 | 64371135 |
Abdominal pain upper | 27.71 | 9.45 | 208 | 123025 | 174822 | 64200677 |
Abdominal pain | 27.65 | 9.45 | 425 | 122808 | 311950 | 64063549 |
Confusional state | 27.13 | 9.45 | 344 | 122889 | 260800 | 64114699 |
Hepatotoxicity | 26.99 | 9.45 | 22 | 123211 | 39940 | 64335559 |
Upper airway obstruction | 26.92 | 9.45 | 21 | 123212 | 1237 | 64374262 |
Drug resistance | 26.75 | 9.45 | 17 | 123216 | 35085 | 64340414 |
Haematochezia | 26.73 | 9.45 | 54 | 123179 | 66319 | 64309180 |
Hyperthermia malignant | 26.68 | 9.45 | 28 | 123205 | 2431 | 64373068 |
Jaundice | 26.67 | 9.45 | 32 | 123201 | 48480 | 64327019 |
Harlequin syndrome | 25.69 | 9.45 | 8 | 123225 | 55 | 64375444 |
Nerve block | 25.40 | 9.45 | 13 | 123220 | 362 | 64375137 |
Corneal epithelium defect | 25.37 | 9.45 | 16 | 123217 | 669 | 64374830 |
Oedema peripheral | 25.35 | 9.45 | 268 | 122965 | 210049 | 64165450 |
Vasospasm | 25.32 | 9.45 | 18 | 123215 | 920 | 64374579 |
Familial periodic paralysis | 25.24 | 9.45 | 10 | 123223 | 149 | 64375350 |
Pupil fixed | 25.20 | 9.45 | 31 | 123202 | 3201 | 64372298 |
Death | 25.18 | 9.45 | 716 | 122517 | 481989 | 63893510 |
Tubulointerstitial nephritis | 24.91 | 9.45 | 14 | 123219 | 30895 | 64344604 |
Spinal anaesthesia | 24.75 | 9.45 | 8 | 123225 | 63 | 64375436 |
Respiratory failure | 24.67 | 9.45 | 439 | 122794 | 160744 | 64214755 |
Illness | 24.66 | 9.45 | 95 | 123138 | 21843 | 64353656 |
Status epilepticus | 24.51 | 9.45 | 94 | 123139 | 21569 | 64353930 |
Psoriatic arthropathy | 24.38 | 9.45 | 28 | 123205 | 43253 | 64332246 |
Product administration error | 24.27 | 9.45 | 111 | 123122 | 27532 | 64347967 |
Infusion site urticaria | 24.24 | 9.45 | 15 | 123218 | 606 | 64374893 |
Extremity necrosis | 24.24 | 9.45 | 28 | 123205 | 2706 | 64372793 |
Vasoconstriction | 24.09 | 9.45 | 15 | 123218 | 613 | 64374886 |
Sinus bradycardia | 24.01 | 9.45 | 97 | 123136 | 22796 | 64352703 |
Atrioventricular block complete | 23.78 | 9.45 | 71 | 123162 | 14347 | 64361152 |
PCO2 increased | 23.70 | 9.45 | 22 | 123211 | 1645 | 64373854 |
Liver function test abnormal | 23.35 | 9.45 | 49 | 123184 | 59352 | 64316147 |
Spinal cord oedema | 23.19 | 9.45 | 12 | 123221 | 342 | 64375157 |
Peripheral swelling | 23.04 | 9.45 | 272 | 122961 | 208881 | 64166618 |
Gastrointestinal haemorrhage | 23.01 | 9.45 | 153 | 123080 | 132159 | 64243340 |
Compartment syndrome | 22.92 | 9.45 | 34 | 123199 | 4198 | 64371301 |
PO2 decreased | 22.75 | 9.45 | 27 | 123206 | 2686 | 64372813 |
Type 2 diabetes mellitus | 22.64 | 9.45 | 19 | 123214 | 34001 | 64341498 |
Respiratory arrest | 22.59 | 9.45 | 176 | 123057 | 52809 | 64322690 |
White blood cell count decreased | 22.48 | 9.45 | 193 | 123040 | 157644 | 64217855 |
Lung hyperinflation | 22.39 | 9.45 | 21 | 123212 | 1591 | 64373908 |
Propofol infusion syndrome | 22.34 | 9.45 | 21 | 123212 | 1596 | 64373903 |
International normalised ratio increased | 22.29 | 9.45 | 77 | 123156 | 79090 | 64296409 |
Supraventricular tachycardia | 22.18 | 9.45 | 83 | 123150 | 18824 | 64356675 |
Eosinophilia | 22.14 | 9.45 | 24 | 123209 | 38052 | 64337447 |
Cytomegalovirus infection | 22.13 | 9.45 | 23 | 123210 | 37176 | 64338323 |
Embolia cutis medicamentosa | 22.02 | 9.45 | 13 | 123220 | 482 | 64375017 |
Coronary artery disease | 22 | 9.45 | 52 | 123181 | 60381 | 64315118 |
Fear of death | 21.80 | 9.45 | 19 | 123214 | 1308 | 64374191 |
Phrenic nerve paralysis | 21.77 | 9.45 | 10 | 123223 | 218 | 64375281 |
Eyelid oedema | 21.72 | 9.45 | 62 | 123171 | 12217 | 64363282 |
Bursitis infective | 21.39 | 9.45 | 18 | 123215 | 1182 | 64374317 |
Foreign body | 21.33 | 9.45 | 25 | 123208 | 2454 | 64373045 |
Sleep disorder | 21.24 | 9.45 | 52 | 123181 | 59657 | 64315842 |
Ventricular arrhythmia | 21.18 | 9.45 | 45 | 123188 | 7370 | 64368129 |
Rectal prolapse | 21.18 | 9.45 | 21 | 123212 | 1705 | 64373794 |
Brain oedema | 21.16 | 9.45 | 91 | 123142 | 21984 | 64353515 |
Administration site swelling | 21.11 | 9.45 | 11 | 123222 | 318 | 64375181 |
Drug abuse | 21.09 | 9.45 | 157 | 123076 | 132217 | 64243282 |
Pharyngeal swelling | 21.06 | 9.45 | 38 | 123195 | 5521 | 64369978 |
Infusion site haemorrhage | 21.01 | 9.45 | 24 | 123209 | 2291 | 64373208 |
Gastrointestinal disorder | 20.96 | 9.45 | 94 | 123139 | 89615 | 64285884 |
Platelet count decreased | 20.91 | 9.45 | 212 | 123021 | 167499 | 64208000 |
Inhibitory drug interaction | 20.89 | 9.45 | 30 | 123203 | 3597 | 64371902 |
Abortion spontaneous | 20.83 | 9.45 | 11 | 123222 | 25132 | 64350367 |
Eye inflammation | 20.75 | 9.45 | 35 | 123198 | 4822 | 64370677 |
Pallor | 20.70 | 9.45 | 136 | 123097 | 38645 | 64336854 |
Parophthalmia | 20.68 | 9.45 | 11 | 123222 | 332 | 64375167 |
C-reactive protein increased | 20.67 | 9.45 | 102 | 123131 | 94807 | 64280692 |
Glucose tolerance impaired | 20.64 | 9.45 | 41 | 123192 | 6402 | 64369097 |
Eye infection | 20.62 | 9.45 | 51 | 123182 | 9230 | 64366269 |
Infusion site nodule | 20.59 | 9.45 | 10 | 123223 | 248 | 64375251 |
Diabetes mellitus | 20.56 | 9.45 | 62 | 123171 | 66412 | 64309087 |
Quadriplegia | 20.49 | 9.45 | 27 | 123206 | 2986 | 64372513 |
Dry gangrene | 20.32 | 9.45 | 15 | 123218 | 813 | 64374686 |
Apnoeic attack | 20.30 | 9.45 | 13 | 123220 | 558 | 64374941 |
Intracranial hypotension | 20.30 | 9.45 | 11 | 123222 | 345 | 64375154 |
Axillary nerve injury | 20.22 | 9.45 | 5 | 123228 | 12 | 64375487 |
Pupillary reflex impaired | 20.07 | 9.45 | 27 | 123206 | 3046 | 64372453 |
Product preparation error | 20.02 | 9.45 | 31 | 123202 | 3974 | 64371525 |
Device ineffective | 19.79 | 9.45 | 8 | 123225 | 126 | 64375373 |
Punctate keratitis | 19.74 | 9.45 | 15 | 123218 | 850 | 64374649 |
Pain in extremity | 19.71 | 9.45 | 435 | 122798 | 302650 | 64072849 |
Aplastic anaemia | 19.69 | 9.45 | 65 | 123168 | 13855 | 64361644 |
Inappropriate antidiuretic hormone secretion | 19.60 | 9.45 | 9 | 123224 | 22280 | 64353219 |
Ischaemia | 19.45 | 9.45 | 43 | 123190 | 7235 | 64368264 |
Food allergy | 19.44 | 9.45 | 45 | 123188 | 7806 | 64367693 |
Hypoglycaemia | 19.35 | 9.45 | 97 | 123136 | 89795 | 64285704 |
Atonic urinary bladder | 19.35 | 9.45 | 7 | 123226 | 80 | 64375419 |
Administration site pain | 19.18 | 9.45 | 11 | 123222 | 386 | 64375113 |
Reversible cerebral vasoconstriction syndrome | 19.13 | 9.45 | 23 | 123210 | 2319 | 64373180 |
Poor quality product administered | 19.12 | 9.45 | 27 | 123206 | 3188 | 64372311 |
Neuromuscular blockade | 19.02 | 9.45 | 12 | 123221 | 502 | 64374997 |
Systemic toxicity | 18.97 | 9.45 | 7 | 123226 | 85 | 64375414 |
Accelerated idioventricular rhythm | 18.77 | 9.45 | 8 | 123225 | 145 | 64375354 |
Eyelid ptosis | 18.74 | 9.45 | 50 | 123183 | 9475 | 64366024 |
Device malfunction | 18.72 | 9.45 | 75 | 123158 | 17558 | 64357941 |
Liver disorder | 18.56 | 9.45 | 47 | 123186 | 53304 | 64322195 |
Heart rate increased | 18.53 | 9.45 | 278 | 122955 | 98397 | 64277102 |
Sinus arrest | 18.45 | 9.45 | 26 | 123207 | 3064 | 64372435 |
Renal failure | 18.42 | 9.45 | 466 | 122767 | 181222 | 64194277 |
Arthritis bacterial | 18.40 | 9.45 | 44 | 123189 | 7795 | 64367704 |
Arterial spasm | 18.33 | 9.45 | 8 | 123225 | 154 | 64375345 |
Product administered at inappropriate site | 18.32 | 9.45 | 26 | 123207 | 3084 | 64372415 |
Blood cholesterol increased | 18.29 | 9.45 | 43 | 123190 | 50023 | 64325476 |
Progressive multifocal leukoencephalopathy | 18.29 | 9.45 | 6 | 123227 | 18226 | 64357273 |
Osteonecrosis of jaw | 18.18 | 9.45 | 30 | 123203 | 39795 | 64335704 |
Pneumocephalus | 18.08 | 9.45 | 9 | 123224 | 236 | 64375263 |
Hypercalcaemia | 18.05 | 9.45 | 20 | 123213 | 31396 | 64344103 |
Pancreatitis acute | 18.01 | 9.45 | 34 | 123199 | 42821 | 64332678 |
Constipation | 17.97 | 9.45 | 319 | 122914 | 229018 | 64146481 |
Treatment failure | 17.93 | 9.45 | 140 | 123093 | 116676 | 64258823 |
Hypercapnia | 17.86 | 9.45 | 43 | 123190 | 7651 | 64367848 |
Red blood cell sedimentation rate increased | 17.82 | 9.45 | 20 | 123213 | 31215 | 64344284 |
Neurotoxicity | 17.73 | 9.45 | 101 | 123132 | 27303 | 64348196 |
Depressed mood | 17.71 | 9.45 | 32 | 123201 | 40980 | 64334519 |
Injection site inflammation | 17.62 | 9.45 | 26 | 123207 | 3195 | 64372304 |
Troponin T increased | 17.43 | 9.45 | 22 | 123211 | 2331 | 64373168 |
Postpartum disorder | 17.40 | 9.45 | 4 | 123229 | 6 | 64375493 |
Mental status changes | 17.33 | 9.45 | 186 | 123047 | 60976 | 64314523 |
Brain injury | 17.32 | 9.45 | 50 | 123183 | 9915 | 64365584 |
Malaise | 17.19 | 9.45 | 602 | 122631 | 395645 | 63979854 |
Migraine | 17.02 | 9.45 | 189 | 123044 | 62488 | 64313011 |
No adverse event | 17.01 | 9.45 | 103 | 123130 | 28458 | 64347041 |
Glossoptosis | 16.95 | 9.45 | 8 | 123225 | 186 | 64375313 |
Infection | 16.86 | 9.45 | 250 | 122983 | 184630 | 64190869 |
Tracheal deviation | 16.79 | 9.45 | 6 | 123227 | 66 | 64375433 |
Injection site joint infection | 16.78 | 9.45 | 5 | 123228 | 29 | 64375470 |
Neoplasm progression | 16.78 | 9.45 | 33 | 123200 | 40931 | 64334568 |
Pneumocystis jirovecii pneumonia | 16.54 | 9.45 | 17 | 123216 | 27617 | 64347882 |
Infusion site rash | 16.51 | 9.45 | 15 | 123218 | 1091 | 64374408 |
Metastases to liver | 16.39 | 9.45 | 13 | 123220 | 23928 | 64351571 |
Retinal vascular occlusion | 16.37 | 9.45 | 11 | 123222 | 513 | 64374986 |
Epinephrine increased | 16.35 | 9.45 | 4 | 123229 | 9 | 64375490 |
Weight increased | 16.33 | 9.45 | 298 | 122935 | 213050 | 64162449 |
Monoplegia | 16.31 | 9.45 | 26 | 123207 | 3417 | 64372082 |
Dehydration | 16.20 | 9.45 | 304 | 122929 | 216459 | 64159040 |
Blindness cortical | 16.17 | 9.45 | 13 | 123220 | 800 | 64374699 |
Phaeochromocytoma crisis | 16.16 | 9.45 | 9 | 123224 | 298 | 64375201 |
Pulmonary fibrosis | 16.12 | 9.45 | 20 | 123213 | 29858 | 64345641 |
Inadequate analgesia | 16.11 | 9.45 | 28 | 123205 | 3950 | 64371549 |
Catecholamine crisis | 16.11 | 9.45 | 5 | 123228 | 34 | 64375465 |
Neurogenic shock | 16.08 | 9.45 | 11 | 123222 | 528 | 64374971 |
Cardiopulmonary failure | 15.98 | 9.45 | 36 | 123197 | 6134 | 64369365 |
Normal newborn | 15.94 | 9.45 | 34 | 123199 | 5583 | 64369916 |
Postresuscitation encephalopathy | 15.86 | 9.45 | 5 | 123228 | 36 | 64375463 |
Irregular breathing | 15.79 | 9.45 | 10 | 123223 | 421 | 64375078 |
Drug-induced liver injury | 15.79 | 9.45 | 43 | 123190 | 47600 | 64327899 |
Application site pallor | 15.79 | 9.45 | 3 | 123230 | 0 | 64375499 |
Hypercatabolism | 15.79 | 9.45 | 3 | 123230 | 0 | 64375499 |
Liquid product physical issue | 15.77 | 9.45 | 13 | 123220 | 829 | 64374670 |
Ascites | 15.69 | 9.45 | 63 | 123170 | 61938 | 64313561 |
Meningitis | 15.66 | 9.45 | 43 | 123190 | 8286 | 64367213 |
Condition aggravated | 15.65 | 9.45 | 568 | 122665 | 371858 | 64003641 |
Abnormal behaviour | 15.65 | 9.45 | 25 | 123208 | 33597 | 64341902 |
Balance disorder | 15.64 | 9.45 | 95 | 123138 | 83831 | 64291668 |
Stomatitis | 15.61 | 9.45 | 134 | 123099 | 109471 | 64266028 |
Left ventricular dysfunction | 15.57 | 9.45 | 69 | 123164 | 16885 | 64358614 |
Spinal epidural haemorrhage | 15.48 | 9.45 | 7 | 123226 | 147 | 64375352 |
Peritonitis | 15.43 | 9.45 | 15 | 123218 | 25008 | 64350491 |
Hip arthroplasty | 15.38 | 9.45 | 11 | 123222 | 21340 | 64354159 |
Obstructive airways disorder | 15.36 | 9.45 | 86 | 123147 | 23099 | 64352400 |
Application site alopecia | 15.29 | 9.45 | 4 | 123229 | 13 | 64375486 |
Respiratory tract infection | 15.26 | 9.45 | 123 | 123110 | 37284 | 64338215 |
Skin test positive | 15.17 | 9.45 | 14 | 123219 | 1039 | 64374460 |
Liver injury | 15.16 | 9.45 | 21 | 123212 | 29911 | 64345588 |
Diplegia | 15.13 | 9.45 | 17 | 123216 | 1594 | 64373905 |
Swelling face | 14.98 | 9.45 | 176 | 123057 | 58990 | 64316509 |
Procedural pain | 14.92 | 9.45 | 64 | 123169 | 15444 | 64360055 |
Gastroenteritis | 14.89 | 9.45 | 21 | 123212 | 29690 | 64345809 |
ECG signs of myocardial ischaemia | 14.85 | 9.45 | 9 | 123224 | 350 | 64375149 |
Graft versus host disease | 14.85 | 9.45 | 4 | 123229 | 13809 | 64361690 |
Foetal heart rate abnormal | 14.85 | 9.45 | 8 | 123225 | 248 | 64375251 |
Vitamin D increased | 14.81 | 9.45 | 10 | 123223 | 470 | 64375029 |
Cholestasis of pregnancy | 14.71 | 9.45 | 13 | 123220 | 912 | 64374587 |
Capillary nail refill test abnormal | 14.69 | 9.45 | 5 | 123228 | 47 | 64375452 |
Myocardial necrosis marker increased | 14.61 | 9.45 | 22 | 123211 | 2753 | 64372746 |
Tracheitis | 14.56 | 9.45 | 15 | 123218 | 1275 | 64374224 |
Hypomagnesaemia | 14.55 | 9.45 | 31 | 123202 | 37345 | 64338154 |
Blood pressure increased | 14.49 | 9.45 | 432 | 122801 | 172120 | 64203379 |
Haemoglobin decreased | 14.44 | 9.45 | 274 | 122959 | 194789 | 64180710 |
Epidural analgesia | 14.42 | 9.45 | 5 | 123228 | 50 | 64375449 |
Cold sweat | 14.39 | 9.45 | 66 | 123167 | 16389 | 64359110 |
Cranial nerve palsies multiple | 14.32 | 9.45 | 6 | 123227 | 104 | 64375395 |
Gait disturbance | 14.28 | 9.45 | 237 | 122996 | 171918 | 64203581 |
Scar | 14.23 | 9.45 | 57 | 123176 | 13341 | 64362158 |
Diabetes mellitus inadequate control | 14.07 | 9.45 | 12 | 123221 | 21309 | 64354190 |
Enzyme induction | 14.06 | 9.45 | 6 | 123227 | 109 | 64375390 |
Creatinine renal clearance decreased | 14.02 | 9.45 | 5 | 123228 | 14416 | 64361083 |
Acute pulmonary oedema | 14.01 | 9.45 | 55 | 123178 | 12754 | 64362745 |
Torsade de pointes | 13.99 | 9.45 | 68 | 123165 | 17295 | 64358204 |
Therapeutic product effect prolonged | 13.96 | 9.45 | 10 | 123223 | 517 | 64374982 |
Eye infection intraocular | 13.92 | 9.45 | 4 | 123229 | 20 | 64375479 |
Trigeminal palsy | 13.92 | 9.45 | 4 | 123229 | 20 | 64375479 |
Incision site rash | 13.92 | 9.45 | 4 | 123229 | 20 | 64375479 |
Myelosuppression | 13.88 | 9.45 | 15 | 123218 | 23815 | 64351684 |
Exposure during pregnancy | 13.87 | 9.45 | 217 | 123016 | 77458 | 64298041 |
Hypercholesterolaemia | 13.85 | 9.45 | 6 | 123227 | 15367 | 64360132 |
Gamma-glutamyltransferase increased | 13.78 | 9.45 | 47 | 123186 | 48463 | 64327036 |
Forced vital capacity abnormal | 13.76 | 9.45 | 4 | 123229 | 21 | 64375478 |
Caffeine allergy | 13.76 | 9.45 | 4 | 123229 | 21 | 64375478 |
Air embolism | 13.72 | 9.45 | 9 | 123224 | 403 | 64375096 |
Airway complication of anaesthesia | 13.72 | 9.45 | 9 | 123224 | 403 | 64375096 |
Removal of foreign body from throat | 13.71 | 9.45 | 3 | 123230 | 3 | 64375496 |
Laryngospasm | 13.63 | 9.45 | 24 | 123209 | 3421 | 64372078 |
Skin ulcer | 13.61 | 9.45 | 41 | 123192 | 43933 | 64331566 |
Atrophy of globe | 13.60 | 9.45 | 5 | 123228 | 60 | 64375439 |
Product use issue | 13.54 | 9.45 | 206 | 123027 | 151509 | 64223990 |
Post lumbar puncture syndrome | 13.53 | 9.45 | 11 | 123222 | 688 | 64374811 |
Radiculopathy | 13.47 | 9.45 | 32 | 123201 | 5646 | 64369853 |
Cardiac assistance device user | 13.45 | 9.45 | 5 | 123228 | 62 | 64375437 |
Pupillary light reflex tests abnormal | 13.42 | 9.45 | 8 | 123225 | 302 | 64375197 |
SARS-CoV-2 test positive | 13.39 | 9.45 | 34 | 123199 | 6252 | 64369247 |
Staphylococcal infection | 13.39 | 9.45 | 152 | 123081 | 50526 | 64324973 |
Amaurosis | 13.36 | 9.45 | 13 | 123220 | 1031 | 64374468 |
Cardio-respiratory arrest | 13.32 | 9.45 | 263 | 122970 | 98130 | 64277369 |
Bone marrow failure | 13.26 | 9.45 | 47 | 123186 | 47905 | 64327594 |
Disease recurrence | 13.24 | 9.45 | 25 | 123208 | 31485 | 64344014 |
Spinal epidural haematoma | 13.22 | 9.45 | 14 | 123219 | 1228 | 64374271 |
Neuroleptic malignant syndrome | 13.20 | 9.45 | 17 | 123216 | 24979 | 64350520 |
Neutropenic sepsis | 13.17 | 9.45 | 15 | 123218 | 23257 | 64352242 |
Conjunctival oedema | 13.16 | 9.45 | 13 | 123220 | 1051 | 64374448 |
Diabetic ketoacidosis | 13.14 | 9.45 | 23 | 123210 | 29822 | 64345677 |
Rectal haemorrhage | 13.14 | 9.45 | 67 | 123166 | 61750 | 64313749 |
Respiratory tract oedema | 13.11 | 9.45 | 11 | 123222 | 719 | 64374780 |
Optic nerve injury | 13.09 | 9.45 | 10 | 123223 | 571 | 64374928 |
Macroglossia | 13.07 | 9.45 | 13 | 123220 | 1059 | 64374440 |
Obesity | 13.06 | 9.45 | 12 | 123221 | 20550 | 64354949 |
Distributive shock | 13.06 | 9.45 | 17 | 123216 | 1858 | 64373641 |
Vascular resistance systemic decreased | 13.05 | 9.45 | 7 | 123226 | 215 | 64375284 |
Post-anoxic myoclonus | 13.04 | 9.45 | 4 | 123229 | 26 | 64375473 |
Chest discomfort | 13.03 | 9.45 | 302 | 122931 | 115804 | 64259695 |
Loss of personal independence in daily activities | 12.99 | 9.45 | 83 | 123150 | 72371 | 64303128 |
Urticaria chronic | 12.98 | 9.45 | 9 | 123224 | 442 | 64375057 |
Rheumatoid nodule | 12.98 | 9.45 | 4 | 123229 | 12647 | 64362852 |
Arthritis infective | 12.93 | 9.45 | 36 | 123197 | 6994 | 64368505 |
Palmar-plantar erythrodysaesthesia syndrome | 12.88 | 9.45 | 22 | 123211 | 28797 | 64346702 |
Chemical burn | 12.87 | 9.45 | 9 | 123224 | 448 | 64375051 |
Nail bed tenderness | 12.87 | 9.45 | 8 | 123225 | 326 | 64375173 |
Allodynia | 12.85 | 9.45 | 14 | 123219 | 1269 | 64374230 |
Discomfort | 12.84 | 9.45 | 96 | 123137 | 80782 | 64294717 |
Oxidative stress | 12.79 | 9.45 | 4 | 123229 | 28 | 64375471 |
Injury corneal | 12.78 | 9.45 | 5 | 123228 | 72 | 64375427 |
Optic atrophy | 12.74 | 9.45 | 16 | 123217 | 1687 | 64373812 |
Pharyngitis streptococcal | 12.73 | 9.45 | 41 | 123192 | 8627 | 64366872 |
Anal ulcer | 12.70 | 9.45 | 13 | 123220 | 1096 | 64374403 |
Immune reconstitution inflammatory syndrome | 12.69 | 9.45 | 4 | 123229 | 12466 | 64363033 |
Nodal rhythm | 12.66 | 9.45 | 21 | 123212 | 2853 | 64372646 |
Arthritis | 12.60 | 9.45 | 101 | 123132 | 83713 | 64291786 |
Bundle branch block left | 12.57 | 9.45 | 45 | 123188 | 9989 | 64365510 |
Nystagmus | 12.52 | 9.45 | 42 | 123191 | 9026 | 64366473 |
Injection site necrosis | 12.48 | 9.45 | 14 | 123219 | 1311 | 64374188 |
Rotator cuff syndrome | 12.46 | 9.45 | 51 | 123182 | 12056 | 64363443 |
Schizophrenia | 12.45 | 9.45 | 3 | 123230 | 11165 | 64364334 |
Foreign body in respiratory tract | 12.40 | 9.45 | 8 | 123225 | 348 | 64375151 |
Hepatitis | 12.39 | 9.45 | 45 | 123188 | 45537 | 64329962 |
Pneumonia mycoplasmal | 12.38 | 9.45 | 14 | 123219 | 1322 | 64374177 |
Myelodysplastic syndrome | 12.38 | 9.45 | 21 | 123212 | 27558 | 64347941 |
Tongue pruritus | 12.34 | 9.45 | 9 | 123224 | 479 | 64375020 |
Vocal cord disorder | 12.32 | 9.45 | 14 | 123219 | 1329 | 64374170 |
Product prescribing error | 12.32 | 9.45 | 31 | 123202 | 35238 | 64340261 |
Hypoventilation | 12.29 | 9.45 | 32 | 123201 | 5974 | 64369525 |
Vitreous disorder | 12.27 | 9.45 | 7 | 123226 | 243 | 64375256 |
Mania | 12.25 | 9.45 | 8 | 123225 | 16278 | 64359221 |
Local reaction | 12.22 | 9.45 | 9 | 123224 | 486 | 64375013 |
Exophthalmos | 12.22 | 9.45 | 15 | 123218 | 1545 | 64373954 |
End-tidal CO2 decreased | 12.11 | 9.45 | 4 | 123229 | 34 | 64375465 |
Vitreous floaters | 12.08 | 9.45 | 33 | 123200 | 6340 | 64369159 |
Body dysmorphic disorder | 12.04 | 9.45 | 7 | 123226 | 252 | 64375247 |
Diplopia | 12.02 | 9.45 | 90 | 123143 | 26675 | 64348824 |
Injection site atrophy | 11.98 | 9.45 | 8 | 123225 | 369 | 64375130 |
Intraocular pressure increased | 11.95 | 9.45 | 39 | 123194 | 8263 | 64367236 |
Rash | 11.94 | 9.45 | 736 | 122497 | 457813 | 63917686 |
Heart rate decreased | 11.88 | 9.45 | 159 | 123074 | 54908 | 64320591 |
Dermatitis contact | 11.82 | 9.45 | 41 | 123192 | 8959 | 64366540 |
Opisthotonus | 11.82 | 9.45 | 10 | 123223 | 661 | 64374838 |
Retinal haemorrhage | 11.79 | 9.45 | 36 | 123197 | 7362 | 64368137 |
Malignant melanoma | 11.77 | 9.45 | 5 | 123228 | 12959 | 64362540 |
Transient ischaemic attack | 11.75 | 9.45 | 44 | 123189 | 44138 | 64331361 |
Colour blindness | 11.72 | 9.45 | 8 | 123225 | 383 | 64375116 |
Autonomic nervous system imbalance | 11.71 | 9.45 | 25 | 123208 | 4107 | 64371392 |
Lung disorder | 11.68 | 9.45 | 68 | 123165 | 60632 | 64314867 |
Administration site discolouration | 11.65 | 9.45 | 3 | 123230 | 9 | 64375490 |
Infusion site reaction | 11.65 | 9.45 | 17 | 123216 | 2069 | 64373430 |
Areflexia | 11.64 | 9.45 | 28 | 123205 | 4979 | 64370520 |
Myopathy | 11.61 | 9.45 | 10 | 123223 | 17670 | 64357829 |
Madarosis | 11.60 | 9.45 | 18 | 123215 | 2312 | 64373187 |
Seizure like phenomena | 11.54 | 9.45 | 15 | 123218 | 1637 | 64373862 |
Femoral nerve injury | 11.53 | 9.45 | 4 | 123229 | 40 | 64375459 |
Anaphylactoid syndrome of pregnancy | 11.53 | 9.45 | 4 | 123229 | 40 | 64375459 |
Symblepharon | 11.53 | 9.45 | 6 | 123227 | 173 | 64375326 |
Hypocalcaemia | 11.49 | 9.45 | 41 | 123192 | 41712 | 64333787 |
Troponin increased | 11.48 | 9.45 | 59 | 123174 | 15340 | 64360159 |
XIIth nerve injury | 11.41 | 9.45 | 3 | 123230 | 10 | 64375489 |
Central venous catheter removal | 11.39 | 9.45 | 8 | 123225 | 401 | 64375098 |
Serotonin syndrome | 11.38 | 9.45 | 120 | 123113 | 39162 | 64336337 |
Injection site pain | 11.35 | 9.45 | 286 | 122947 | 111122 | 64264377 |
Myocardial infarction | 11.35 | 9.45 | 236 | 122997 | 165585 | 64209914 |
Product contamination | 11.29 | 9.45 | 12 | 123221 | 1057 | 64374442 |
Reperfusion arrhythmia | 11.26 | 9.45 | 7 | 123226 | 285 | 64375214 |
Myocardial stunning | 11.25 | 9.45 | 6 | 123227 | 182 | 64375317 |
Type IV hypersensitivity reaction | 11.23 | 9.45 | 22 | 123211 | 3400 | 64372099 |
Pain in jaw | 11.23 | 9.45 | 40 | 123193 | 40715 | 64334784 |
Retinal ischaemia | 11.21 | 9.45 | 10 | 123223 | 710 | 64374789 |
Injection site oedema | 11.19 | 9.45 | 12 | 123221 | 1068 | 64374431 |
Electrocardiogram ST-T segment depression | 11.19 | 9.45 | 3 | 123230 | 11 | 64375488 |
Tachypnoea | 11.18 | 9.45 | 88 | 123145 | 26483 | 64349016 |
Electrocardiogram P wave abnormal | 11.18 | 9.45 | 7 | 123226 | 289 | 64375210 |
Electrocardiogram T wave amplitude decreased | 11.17 | 9.45 | 9 | 123224 | 556 | 64374943 |
Nervous system disorder | 11.17 | 9.45 | 79 | 123154 | 22999 | 64352500 |
Dermatitis exfoliative | 11.12 | 9.45 | 3 | 123230 | 10349 | 64365150 |
Vocal cord dysfunction | 11.11 | 9.45 | 8 | 123225 | 417 | 64375082 |
Corneal opacity | 11.08 | 9.45 | 11 | 123222 | 894 | 64374605 |
Photosensitivity reaction | 11.08 | 9.45 | 11 | 123222 | 18162 | 64357337 |
Poisoning deliberate | 10.98 | 9.45 | 6 | 123227 | 13452 | 64362047 |
Suicide attempt | 10.94 | 9.45 | 85 | 123148 | 70922 | 64304577 |
Product preparation issue | 10.93 | 9.45 | 10 | 123223 | 734 | 64374765 |
Hepatic cirrhosis | 10.93 | 9.45 | 21 | 123212 | 26277 | 64349222 |
Lung neoplasm malignant | 10.91 | 9.45 | 15 | 123218 | 21433 | 64354066 |
Headache | 10.90 | 9.45 | 1163 | 122070 | 528304 | 63847195 |
Product measured potency issue | 10.82 | 9.45 | 6 | 123227 | 197 | 64375302 |
Oral herpes | 10.82 | 9.45 | 76 | 123157 | 22076 | 64353423 |
Victim of spousal abuse | 10.79 | 9.45 | 3 | 123230 | 13 | 64375486 |
Irritable bowel syndrome | 10.75 | 9.45 | 36 | 123197 | 37333 | 64338166 |
Myokymia | 10.72 | 9.45 | 5 | 123228 | 113 | 64375386 |
Alanine aminotransferase increased | 10.69 | 9.45 | 194 | 123039 | 138837 | 64236662 |
Neuropathy peripheral | 10.68 | 9.45 | 159 | 123074 | 117366 | 64258133 |
Corneal abrasion | 10.65 | 9.45 | 11 | 123222 | 937 | 64374562 |
Hallucination, auditory | 10.62 | 9.45 | 10 | 123223 | 16929 | 64358570 |
Oxygen saturation decreased | 10.59 | 9.45 | 274 | 122959 | 106902 | 64268597 |
Cardiac procedure complication | 10.58 | 9.45 | 7 | 123226 | 318 | 64375181 |
Electrocardiogram U wave present | 10.56 | 9.45 | 5 | 123228 | 117 | 64375382 |
Hepatitis cholestatic | 10.55 | 9.45 | 5 | 123228 | 12150 | 64363349 |
N-terminal prohormone brain natriuretic peptide | 10.52 | 9.45 | 4 | 123229 | 53 | 64375446 |
Treatment noncompliance | 10.49 | 9.45 | 45 | 123188 | 43437 | 64332062 |
Product confusion | 10.44 | 9.45 | 3 | 123230 | 15 | 64375484 |
Musculoskeletal pain | 10.44 | 9.45 | 102 | 123131 | 81192 | 64294307 |
Coccygectomy | 10.44 | 9.45 | 3 | 123230 | 15 | 64375484 |
Disseminated intravascular coagulation | 10.42 | 9.45 | 101 | 123132 | 32247 | 64343252 |
pH body fluid abnormal | 10.41 | 9.45 | 5 | 123228 | 121 | 64375378 |
Fluid retention | 10.32 | 9.45 | 69 | 123164 | 59537 | 64315962 |
CSF pressure increased | 10.30 | 9.45 | 6 | 123227 | 217 | 64375282 |
Larynx irritation | 10.30 | 9.45 | 5 | 123228 | 124 | 64375375 |
Extrasystoles | 10.24 | 9.45 | 32 | 123201 | 6626 | 64368873 |
Blister | 10.23 | 9.45 | 102 | 123131 | 80865 | 64294634 |
Administration related reaction | 10.22 | 9.45 | 5 | 123228 | 126 | 64375373 |
Paranasal cyst | 10.22 | 9.45 | 7 | 123226 | 337 | 64375162 |
Genital ulceration | 10.15 | 9.45 | 9 | 123224 | 634 | 64374865 |
Injection site nerve damage | 10.13 | 9.45 | 4 | 123229 | 59 | 64375440 |
Oesophageal obstruction | 10.11 | 9.45 | 10 | 123223 | 809 | 64374690 |
Smoke sensitivity | 10.09 | 9.45 | 8 | 123225 | 483 | 64375016 |
Procedural anxiety | 10.08 | 9.45 | 9 | 123224 | 640 | 64374859 |
Cholangitis | 10.08 | 9.45 | 4 | 123229 | 10798 | 64364701 |
Angina pectoris | 10.07 | 9.45 | 48 | 123185 | 45033 | 64330466 |
Tenosynovitis | 10.07 | 9.45 | 5 | 123228 | 11828 | 64363671 |
Foot deformity | 10.05 | 9.45 | 10 | 123223 | 16494 | 64359005 |
Muscle tightness | 10.03 | 9.45 | 45 | 123188 | 11070 | 64364429 |
Polyneuropathy | 10.03 | 9.45 | 14 | 123219 | 19880 | 64355619 |
Hypertension | 10.01 | 9.45 | 598 | 122635 | 258663 | 64116836 |
Enthesopathy | 9.97 | 9.45 | 3 | 123230 | 9635 | 64365864 |
Ocular retrobulbar haemorrhage | 9.94 | 9.45 | 5 | 123228 | 134 | 64375365 |
Product formulation issue | 9.92 | 9.45 | 10 | 123223 | 828 | 64374671 |
Flushing | 9.91 | 9.45 | 208 | 123025 | 78440 | 64297059 |
Incision site pain | 9.88 | 9.45 | 18 | 123215 | 2636 | 64372863 |
Blood pressure immeasurable | 9.86 | 9.45 | 15 | 123218 | 1893 | 64373606 |
Poor quality sleep | 9.84 | 9.45 | 66 | 123167 | 18885 | 64356614 |
Hyperkalaemia | 9.83 | 9.45 | 135 | 123098 | 100994 | 64274505 |
Post transplant lymphoproliferative disorder | 9.82 | 9.45 | 3 | 123230 | 9541 | 64365958 |
Prescribed underdose | 9.78 | 9.45 | 12 | 123221 | 18003 | 64357496 |
Cardiac failure | 9.77 | 9.45 | 186 | 123047 | 132187 | 64243312 |
Brain herniation | 9.68 | 9.45 | 31 | 123202 | 6502 | 64368997 |
Thinking abnormal | 9.65 | 9.45 | 5 | 123228 | 11551 | 64363948 |
Concomitant disease aggravated | 9.63 | 9.45 | 5 | 123228 | 11537 | 64363962 |
No reaction on previous exposure to drug | 9.62 | 9.45 | 6 | 123227 | 246 | 64375253 |
Allergic reaction to excipient | 9.62 | 9.45 | 6 | 123227 | 246 | 64375253 |
Bradyphrenia | 9.60 | 9.45 | 3 | 123230 | 9403 | 64366096 |
Repetitive strain injury | 9.55 | 9.45 | 5 | 123228 | 146 | 64375353 |
Blood creatine phosphokinase increased | 9.54 | 9.45 | 69 | 123164 | 58489 | 64317010 |
Blood pressure fluctuation | 9.51 | 9.45 | 59 | 123174 | 51812 | 64323687 |
Orbital infection | 9.51 | 9.45 | 4 | 123229 | 70 | 64375429 |
Arrhythmia | 9.49 | 9.45 | 148 | 123085 | 52796 | 64322703 |
Fat embolism | 9.47 | 9.45 | 7 | 123226 | 380 | 64375119 |
Anaesthetic complication cardiac | 9.46 | 9.45 | 4 | 123229 | 71 | 64375428 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Methaemoglobinaemia | 32.95 | 27.39 | 10 | 147 | 67 | 84454 |
Cardiac arrest neonatal | 30.99 | 27.39 | 10 | 147 | 84 | 84437 |
Source | Code | Description |
---|---|---|
ATC | A01AD01 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Other agents for local oral treatment |
ATC | B02BC09 | BLOOD AND BLOOD FORMING ORGANS ANTIHEMORRHAGICS VITAMIN K AND OTHER HEMOSTATICS Local hemostatics |
ATC | C01CA24 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES Adrenergic and dopaminergic agents |
ATC | R01AA14 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Sympathomimetics, plain |
ATC | R03AA01 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Alpha- and beta-adrenoreceptor agonists |
ATC | R03AK01 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
ATC | S01EA01 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Sympathomimetics in glaucoma therapy |
ATC | S01EA51 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Sympathomimetics in glaucoma therapy |
FDA CS | M0003647 | Catecholamines |
FDA MoA | N0000000209 | Adrenergic alpha-Agonists |
FDA MoA | N0000000245 | Adrenergic beta-Agonists |
FDA EPC | N0000175552 | alpha-Adrenergic Agonist |
FDA EPC | N0000175555 | beta-Adrenergic Agonist |
FDA EPC | N0000175570 | Catecholamine |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D000322 | Adrenergic Agonists |
MeSH PA | D000316 | Adrenergic alpha-Agonists |
MeSH PA | D000318 | Adrenergic beta-Agonists |
MeSH PA | D018927 | Anti-Asthmatic Agents |
MeSH PA | D001993 | Bronchodilator Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D009184 | Mydriatics |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D019141 | Respiratory System Agents |
MeSH PA | D013566 | Sympathomimetics |
MeSH PA | D014662 | Vasoconstrictor Agents |
CHEBI has role | CHEBI:24621 | hormones |
CHEBI has role | CHEBI:35522 | beta-adrenergic agonists |
CHEBI has role | CHEBI:35523 | bronchodilator |
CHEBI has role | CHEBI:35524 | sympathomimetic |
CHEBI has role | CHEBI:35569 | alpha-adrenergic agonists |
CHEBI has role | CHEBI:35620 | vasodilator agents |
CHEBI has role | CHEBI:37886 | adrenergic agonists |
CHEBI has role | CHEBI:50513 | mydriatics |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Bronchiectasis | indication | 12295008 | DOID:9563 |
Bronchitis | indication | 32398004 | DOID:6132 |
Anaphylaxis | indication | 39579001 | |
Local anesthesia, by infiltration | indication | 44596000 | |
Low blood pressure | indication | 45007003 | |
Wheezing | indication | 56018004 | |
Open-angle glaucoma | indication | 84494001 | DOID:1067 |
Pulmonary emphysema | indication | 87433001 | |
Dyspnea | indication | 267036007 | |
Exacerbation of asthma | indication | 281239006 | |
Asthma management | indication | 406162001 | |
Acute exacerbation of asthma | indication | 708038006 | |
Allergic Reactions | indication | ||
Administration of Local Anesthetic Nerve Block | indication | ||
Ventricular fibrillation | off-label use | 71908006 | |
Asthma | off-label use | 195967001 | DOID:2841 |
Local anesthesia | off-label use | 386761002 | |
Cardiac arrest | off-label use | 410429000 | DOID:0060319 |
Keratitis | contraindication | 5888003 | DOID:4677 |
Bacterial septicemia | contraindication | 10001005 | DOID:0040085 |
Sinus tachycardia | contraindication | 11092001 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Aphakia | contraindication | 24010005 | |
Complete atrioventricular block | contraindication | 27885002 | |
Shock | contraindication | 27942005 | |
Hypovolemia | contraindication | 28560003 | |
Hypercapnia | contraindication | 29596007 | |
Parkinsonism | contraindication | 32798002 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Retinal detachment | contraindication | 42059000 | DOID:5327 |
Hypokalemia | contraindication | 43339004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Stokes-Adams syndrome | contraindication | 46935006 | |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Atrial fibrillation | contraindication | 49436004 | DOID:0060224 |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Sinus bradycardia | contraindication | 49710005 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Iritis | contraindication | 65074000 | DOID:1406 |
Cerebral arteriosclerosis | contraindication | 65312002 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Wolff-Parkinson-White pattern | contraindication | 74390002 | DOID:384 |
Decreased respiratory function | contraindication | 80954004 | |
Cardiogenic shock | contraindication | 89138009 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Open wound | contraindication | 125643001 | |
Seizure disorder | contraindication | 128613002 | |
Bleeding | contraindication | 131148009 | |
Angina pectoris | contraindication | 194828000 | |
Primary dilated cardiomyopathy | contraindication | 195021004 | |
Partial atrioventricular block | contraindication | 195039008 | |
Heart block | contraindication | 233916004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Sepsis syndrome | contraindication | 238150007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Psychoneurotic personality disorder | contraindication | 268634009 | |
Deficiency of cholinesterase | contraindication | 360607009 | |
Hypoxia | contraindication | 389086002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Peripheral vascular disease | contraindication | 400047006 | |
Anterior uveitis | contraindication | 410692006 | DOID:1407 |
Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
Disorder of coronary artery | contraindication | 414024009 | |
Denuded skin | contraindication | 418242004 | |
Thrombosis | contraindication | 439127006 | |
Occlusive Vascular Disease | contraindication | ||
Regional Anesthesia for Labor Pain | contraindication | ||
Lidocaine Toxicity | contraindication | ||
Pupillary Block Glaucoma | contraindication | ||
Reduced Hepatic Blood Flow | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.97 | acidic |
pKa2 | 12.82 | acidic |
pKa3 | 13.64 | acidic |
pKa4 | 8.71 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9833573 | Nov. 23, 2024 | METHOD TO TREAT SEVERE ALLERGIC EMERGENCIES IN PATIENTS WEIGHING 7.5 TO 15 KG (16.5 TO 33 LBS) |
EQ 0.15MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9149579 | July 19, 2025 | METHOD OF TREATING ALLERGIC REACTION VIA INJECTION |
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9149579 | July 19, 2025 | METHOD OF TREATING ALLERGIC REACTION VIA INJECTION |
EQ 0.3MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9149579 | July 19, 2025 | METHOD OF TREATING ALLERGIC REACTION VIA INJECTION |
EQ 0.15MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9724471 | May 23, 2027 | METHOD FOR CONFIRMING DOSE DELIVERY |
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9724471 | May 23, 2027 | METHOD FOR CONFIRMING DOSE DELIVERY |
EQ 0.3MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9724471 | May 23, 2027 | METHOD FOR CONFIRMING DOSE DELIVERY |
1MG/ML (1MG/ML) | EPINEPHRINE | BELCHER | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 10004700 | Aug. 14, 2034 | EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE 1), INCLUDING ANAPHYLAXIS; A METHOD OF TREATING ALLERGIC REACTION, ANAPHYLAXIS, ANAPHYLACTIC SHOCK, OR COMBINATION THEREOF BY AN INJECTION OF AT LEAST ONE DOSAGE OF THE INJECTABLE LIQUID PHARMACEUTICAL |
1MG/ML (1MG/ML) | EPINEPHRINE | BELCHER | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 10039728 | Aug. 14, 2034 | INCREASING MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK |
1MG/ML (1MG/ML) | EPINEPHRINE | BELCHER | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 9283197 | Aug. 15, 2034 | EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS |
1MG/ML (1MG/ML) | EPINEPHRINE | BELCHER | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 9283197 | Aug. 15, 2034 | INCREASING MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK |
1MG/ML (1MG/ML) | EPINEPHRINE | BELCHER | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 9283197 | Aug. 15, 2034 | INDUCTION AND MAINTENANCE OF MYDRIASIS DURING INTRAOCULAR SURGERY |
EQ 1MG BASE/ML (EQ 1MG BASE/ML) | ADRENALIN | PAR STERILE PRODUCTS | N204200 | Dec. 7, 2012 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS | 9295657 | March 13, 2035 | EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS |
EQ 30MG BASE/30ML (EQ 1MG BASE/ML) | ADRENALIN | PAR STERILE PRODUCTS | N204640 | Dec. 18, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS | 9295657 | March 13, 2035 | EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS |
EQ 0.15MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 10688244 | Dec. 21, 2037 | METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR |
EQ 0.15MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 10842938 | Dec. 21, 2037 | METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR |
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 10688244 | Dec. 21, 2037 | METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR |
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 10842938 | Dec. 21, 2037 | METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Alpha-1D adrenergic receptor | GPCR | AGONIST | Ki | 6.66 | CHEMBL | CHEMBL | |||
Alpha-1B adrenergic receptor | GPCR | AGONIST | Ki | 6.50 | IUPHAR | CHEMBL | |||
Alpha-2A adrenergic receptor | GPCR | AGONIST | Ki | 6.56 | DRUG MATRIX | CHEMBL | |||
Beta-2 adrenergic receptor | GPCR | AGONIST | Kd | 6.20 | CHEMBL | CHEMBL | |||
Alpha-1A adrenergic receptor | GPCR | AGONIST | Ki | 5.70 | CHEMBL | CHEMBL | |||
Alpha-2B adrenergic receptor | GPCR | AGONIST | Ki | 6.40 | DRUG MATRIX | CHEMBL | |||
Alpha-2C adrenergic receptor | GPCR | AGONIST | Ki | 6.45 | DRUG MATRIX | CHEMBL | |||
Beta-1 adrenergic receptor | GPCR | Ki | 5.40 | PDSP | |||||
D(1A) dopamine receptor | GPCR | Kd | 4.26 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 6.04 | CHEMBL | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.43 | PDSP | |||||
Alpha-1D adrenergic receptor | GPCR | AGONIST | Ki | 6.30 | IUPHAR | ||||
Mu-type opioid receptor | GPCR | Ki | 5.40 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 5.96 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Ki | 6.18 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Ki | 6.14 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 5.52 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | Ki | 7.89 | CHEMBL | |||||
Adrenergic receptor beta | GPCR | IC50 | 4.54 | CHEMBL | |||||
M18 aspartyl aminopeptidase | Enzyme | IC50 | 5.52 | CHEMBL | |||||
Arachidonate 15-lipoxygenase | Enzyme | IC50 | 5.48 | DRUG MATRIX | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 6.01 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 6.20 | CHEMBL |
ID | Source |
---|---|
4018034 | VUID |
N0000146377 | NUI |
D00996 | KEGG_DRUG |
51-42-3 | SECONDARY_CAS_RN |
4018032 | VANDF |
4018033 | VANDF |
4018034 | VANDF |
C0014563 | UMLSCUI |
CHEBI:28918 | CHEBI |
ALE | PDB_CHEM_ID |
CHEMBL679 | ChEMBL_ID |
DB00668 | DRUGBANK_ID |
CHEMBL1256958 | ChEMBL_ID |
D004837 | MESH_DESCRIPTOR_UI |
5816 | PUBCHEM_CID |
2142 | INN_ID |
479 | IUPHAR_LIGAND_ID |
55-31-2 | SECONDARY_CAS_RN |
YKH834O4BH | UNII |
203180 | RXNORM |
3451 | MMSL |
3500 | MMSL |
4663 | MMSL |
4664 | MMSL |
4665 | MMSL |
4667 | MMSL |
72412 | MMSL |
d00699 | MMSL |
001774 | NDDF |
001776 | NDDF |
006223 | NDDF |
126134000 | SNOMEDCT_US |
387362001 | SNOMEDCT_US |
50685004 | SNOMEDCT_US |
65502005 | SNOMEDCT_US |
CHEMBL3183376 | ChEMBL_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5985 | INJECTION | 0.15 mg | INTRAMUSCULAR | ANDA | 24 sections |
Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5986 | INJECTION | 0.30 mg | INTRAMUSCULAR | ANDA | 24 sections |
epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1694 | INJECTION | 0.30 mg | SUBCUTANEOUS | NDA AUTHORIZED GENERIC | 25 sections |
epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1695 | INJECTION | 0.15 mg | SUBCUTANEOUS | NDA AUTHORIZED GENERIC | 25 sections |
LIDOCAINE HCl and EPINEPHRINE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0264-9378 | INJECTION | 0.01 mg | EPIDURAL | ANDA | 12 sections |
Lidocaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0262 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 23 sections |
Marcaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0557 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 19 sections |
Zorcaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0830 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | NDA | 29 sections |
Lidocaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0898 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 23 sections |
Lignospan Standard | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-1095 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 23 sections |
Lignospan Forte | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-1096 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 23 sections |
Octocaine 50 | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9010 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 24 sections |
Vivacaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9011 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 19 sections |
Vivacaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9011 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 19 sections |
Prilocaine Hydrochloride with Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9013 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 24 sections |
Octocaine 100 | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9023 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 24 sections |
Septocaine and Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9048 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | NDA | 29 sections |
Septocaine and Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9049 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | NDA | 29 sections |
LIDOCAINE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-6500 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 24 sections |
Lidocaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-6512 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 24 sections |
Articaine Hydrochloride and Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-6620 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | NDA | 29 sections |
Articaine Hydrochloride and Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-6625 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | NDA | 29 sections |
Adrenalin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9810 | INJECTION | 1 mg | INTRAMUSCULAR | NDA | 15 sections |
Bupivacaine Hydrochloride and Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-9828 | INJECTION, SOLUTION | 5 ug | INFILTRATION | ANDA | 12 sections |
Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9856 | INJECTION, SOLUTION | 0.10 mg | INTRAVENOUS | unapproved drug other | 11 sections |
EPINEPHRINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9857 | INJECTION, SOLUTION, CONCENTRATE | 1 mg | INTRAVENOUS | NDA | 16 sections |
EPINEPHRINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9857 | INJECTION, SOLUTION, CONCENTRATE | 1 mg | INTRAVENOUS | NDA | 16 sections |
Lidocaine Hydrochloride and Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-9886 | INJECTION, SOLUTION | 5 ug | INFILTRATION | ANDA | 10 sections |
Lidocaine Hydrochloride and Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-9891 | INJECTION, SOLUTION | 10 ug | INFILTRATION | ANDA | 10 sections |
Lidocaine Hydrochloride and Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-9896 | INJECTION, SOLUTION | 10 ug | INFILTRATION | ANDA | 10 sections |