Stem definition | Drug id | CAS RN |
---|---|---|
sympathomimetic, phenethyl derivatives | 1028 | 51-43-4 |
Dose | Unit | Route |
---|---|---|
0.50 | mg | P |
2.24 | mg | Inhal.aerosol |
20 | mg | Inhal.solution |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.09 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 19, 1948 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sinusitis | 802.53 | 9.76 | 1454 | 115225 | 196127 | 55979261 |
Hereditary angioedema | 578.93 | 9.76 | 283 | 116396 | 6552 | 56168836 |
Anaphylactic reaction | 526.21 | 9.76 | 630 | 116049 | 58365 | 56117023 |
Local anaesthetic systemic toxicity | 454.27 | 9.76 | 131 | 116548 | 603 | 56174785 |
Stress cardiomyopathy | 424.85 | 9.76 | 246 | 116433 | 8090 | 56167298 |
Rheumatoid arthritis | 385.13 | 9.76 | 156 | 116523 | 382448 | 55792940 |
Device failure | 376.95 | 9.76 | 199 | 116480 | 5440 | 56169948 |
Toxic anterior segment syndrome | 329.57 | 9.76 | 126 | 116553 | 1556 | 56173832 |
Anaesthetic complication | 310.45 | 9.76 | 122 | 116557 | 1630 | 56173758 |
Contraindicated product administered | 307.49 | 9.76 | 20 | 116659 | 186266 | 55989122 |
Pemphigus | 296.33 | 9.76 | 6 | 116673 | 157206 | 56018182 |
Infusion site pain | 295.63 | 9.76 | 238 | 116441 | 13524 | 56161864 |
Infusion site swelling | 294.24 | 9.76 | 191 | 116488 | 7730 | 56167658 |
Cardiac arrest | 290.07 | 9.76 | 587 | 116092 | 85727 | 56089661 |
Drug intolerance | 279.49 | 9.76 | 100 | 116579 | 264718 | 55910670 |
Infusion site erythema | 272.27 | 9.76 | 196 | 116483 | 9410 | 56165978 |
Hand deformity | 250.06 | 9.76 | 6 | 116673 | 134486 | 56040902 |
Glossodynia | 243.97 | 9.76 | 19 | 116660 | 152439 | 56022949 |
Joint swelling | 240.67 | 9.76 | 152 | 116527 | 289648 | 55885740 |
Anaphylactic shock | 232.23 | 9.76 | 255 | 116424 | 21485 | 56153903 |
Infusion site extravasation | 231.50 | 9.76 | 167 | 116512 | 8043 | 56167345 |
Systemic lupus erythematosus | 229.32 | 9.76 | 47 | 116632 | 180031 | 55995357 |
Accidental exposure to product | 227.49 | 9.76 | 268 | 116411 | 24379 | 56151009 |
Synovitis | 220.74 | 9.76 | 35 | 116644 | 161270 | 56014118 |
Bronchitis | 219.79 | 9.76 | 619 | 116060 | 111692 | 56063696 |
Infusion site pruritus | 203.73 | 9.76 | 126 | 116553 | 4681 | 56170707 |
Upper respiratory tract infection | 193.74 | 9.76 | 445 | 116234 | 70843 | 56104545 |
Alopecia | 191.03 | 9.76 | 196 | 116483 | 293262 | 55882126 |
Hepatic enzyme increased | 187.13 | 9.76 | 61 | 116618 | 171323 | 56004065 |
Chondrolysis | 179.77 | 9.76 | 49 | 116630 | 175 | 56175213 |
Arthropathy | 171.79 | 9.76 | 101 | 116578 | 200174 | 55975214 |
COVID-19 | 167.15 | 9.76 | 434 | 116245 | 74624 | 56100764 |
Pulseless electrical activity | 162.69 | 9.76 | 127 | 116552 | 6897 | 56168491 |
Pericarditis | 155.08 | 9.76 | 21 | 116658 | 108902 | 56066486 |
Wound | 154.00 | 9.76 | 48 | 116631 | 138756 | 56036632 |
Abdominal discomfort | 153.87 | 9.76 | 210 | 116469 | 277064 | 55898324 |
Ear infection | 150.95 | 9.76 | 249 | 116430 | 31046 | 56144342 |
Completed suicide | 143.68 | 9.76 | 49 | 116630 | 133784 | 56041604 |
Therapeutic product effect decreased | 143.12 | 9.76 | 87 | 116592 | 169365 | 56006023 |
Ventricular tachycardia | 141.61 | 9.76 | 175 | 116504 | 16726 | 56158662 |
Infusion site bruising | 135.47 | 9.76 | 80 | 116599 | 2729 | 56172659 |
Bradycardia | 130.93 | 9.76 | 371 | 116308 | 67133 | 56108255 |
Hypotension | 128.49 | 9.76 | 924 | 115755 | 249584 | 55925804 |
Infusion site haemorrhage | 127.26 | 9.76 | 85 | 116594 | 3610 | 56171778 |
General physical health deterioration | 125.45 | 9.76 | 101 | 116578 | 169909 | 56005479 |
Lagophthalmos | 124.24 | 9.76 | 41 | 116638 | 317 | 56175071 |
Helicobacter infection | 123.42 | 9.76 | 7 | 116672 | 73261 | 56102127 |
Kounis syndrome | 122.81 | 9.76 | 58 | 116621 | 1240 | 56174148 |
Headache | 117.49 | 9.76 | 1715 | 114964 | 557329 | 55618059 |
Urticaria | 115.70 | 9.76 | 599 | 116080 | 144077 | 56031311 |
Respiratory tract infection | 114.79 | 9.76 | 240 | 116439 | 35831 | 56139557 |
Treatment failure | 113.95 | 9.76 | 111 | 116568 | 170281 | 56005107 |
Product quality issue | 107.88 | 9.76 | 217 | 116462 | 31519 | 56143869 |
Administration site swelling | 106.47 | 9.76 | 50 | 116629 | 1055 | 56174333 |
Corneal oedema | 105.99 | 9.76 | 54 | 116625 | 1368 | 56174020 |
Infusion site nodule | 103.11 | 9.76 | 51 | 116628 | 1211 | 56174177 |
Arthralgia | 99.99 | 9.76 | 620 | 116059 | 501049 | 55674339 |
Maternal exposure during delivery | 99.32 | 9.76 | 48 | 116631 | 1082 | 56174306 |
Angioedema | 98.80 | 9.76 | 246 | 116433 | 41207 | 56134181 |
Incorrect drug administration rate | 97.50 | 9.76 | 68 | 116611 | 3102 | 56172286 |
Incorrect route of product administration | 96.58 | 9.76 | 165 | 116514 | 21164 | 56154224 |
Shock | 95.65 | 9.76 | 166 | 116513 | 21562 | 56153826 |
Bronchospasm | 91.29 | 9.76 | 136 | 116543 | 15533 | 56159855 |
Fear | 89.16 | 9.76 | 131 | 116548 | 14777 | 56160611 |
Cardiogenic shock | 88.47 | 9.76 | 137 | 116542 | 16188 | 56159200 |
Folliculitis | 84.75 | 9.76 | 8 | 116671 | 54971 | 56120417 |
Asthma | 84.03 | 9.76 | 458 | 116221 | 112312 | 56063076 |
Seasonal allergy | 83.67 | 9.76 | 137 | 116542 | 16971 | 56158417 |
Ventricular fibrillation | 83.18 | 9.76 | 108 | 116571 | 10844 | 56164544 |
Infusion site mass | 81.28 | 9.76 | 46 | 116633 | 1446 | 56173942 |
Illness | 80.35 | 9.76 | 203 | 116476 | 34308 | 56141080 |
Muscle injury | 79.98 | 9.76 | 8 | 116671 | 52492 | 56122896 |
Stridor | 79.41 | 9.76 | 61 | 116618 | 3234 | 56172154 |
Anhedonia | 77.23 | 9.76 | 99 | 116580 | 9815 | 56165573 |
Left ventricle outflow tract obstruction | 76.12 | 9.76 | 26 | 116653 | 226 | 56175162 |
Renal injury | 76.02 | 9.76 | 93 | 116586 | 8794 | 56166594 |
Administration site pain | 75.38 | 9.76 | 35 | 116644 | 719 | 56174669 |
Injection site ischaemia | 74.99 | 9.76 | 15 | 116664 | 3 | 56175385 |
Cauda equina syndrome | 74.22 | 9.76 | 37 | 116642 | 894 | 56174494 |
Unevaluable event | 73.62 | 9.76 | 242 | 116437 | 47445 | 56127943 |
Injury associated with device | 70.21 | 9.76 | 57 | 116622 | 3276 | 56172112 |
Impaired healing | 69.96 | 9.76 | 47 | 116632 | 86794 | 56088594 |
Discomfort | 68.31 | 9.76 | 118 | 116561 | 141643 | 56033745 |
Psoriatic arthropathy | 68.23 | 9.76 | 34 | 116645 | 73974 | 56101414 |
Impaired quality of life | 68.19 | 9.76 | 86 | 116593 | 8388 | 56167000 |
Methaemoglobinaemia | 67.95 | 9.76 | 47 | 116632 | 2115 | 56173273 |
Expired product administered | 67.38 | 9.76 | 70 | 116609 | 5532 | 56169856 |
Tachycardia | 67.12 | 9.76 | 412 | 116267 | 105464 | 56069924 |
Infusion site urticaria | 66.62 | 9.76 | 38 | 116641 | 1213 | 56174175 |
Migraine | 66.32 | 9.76 | 355 | 116324 | 86442 | 56088946 |
Needle issue | 66.10 | 9.76 | 86 | 116593 | 8652 | 56166736 |
Injection site pallor | 65.64 | 9.76 | 17 | 116662 | 47 | 56175341 |
Infusion site rash | 65.61 | 9.76 | 41 | 116638 | 1551 | 56173837 |
Electrocardiogram ST segment elevation | 65.43 | 9.76 | 57 | 116622 | 3612 | 56171776 |
Pulse absent | 63.25 | 9.76 | 64 | 116615 | 4903 | 56170485 |
Endophthalmitis | 62.54 | 9.76 | 52 | 116627 | 3091 | 56172297 |
Product use issue | 62.01 | 9.76 | 189 | 116490 | 185852 | 55989536 |
Arteriospasm coronary | 61.72 | 9.76 | 55 | 116624 | 3592 | 56171796 |
Diarrhoea | 61.47 | 9.76 | 943 | 115736 | 637564 | 55537824 |
Confusional state | 60.80 | 9.76 | 224 | 116455 | 207931 | 55967457 |
Musculoskeletal stiffness | 60.61 | 9.76 | 147 | 116532 | 155860 | 56019528 |
Administration site erythema | 60.22 | 9.76 | 28 | 116651 | 577 | 56174811 |
Neutropenia | 59.91 | 9.76 | 151 | 116528 | 158016 | 56017372 |
Peripheral ischaemia | 59.58 | 9.76 | 59 | 116620 | 4404 | 56170984 |
Liquid product physical issue | 59.04 | 9.76 | 32 | 116647 | 923 | 56174465 |
Product dose omission issue | 58.76 | 9.76 | 666 | 116013 | 204087 | 55971301 |
Swelling | 57.69 | 9.76 | 278 | 116401 | 239493 | 55935895 |
Airway peak pressure increased | 57.44 | 9.76 | 22 | 116657 | 273 | 56175115 |
Urinary tract infection | 57.18 | 9.76 | 755 | 115924 | 239758 | 55935630 |
Type 2 diabetes mellitus | 56.04 | 9.76 | 14 | 116665 | 46848 | 56128540 |
Hyponatraemia | 55.90 | 9.76 | 78 | 116601 | 102061 | 56073327 |
Acute kidney injury | 54.58 | 9.76 | 285 | 116394 | 240478 | 55934910 |
COVID-19 immunisation | 54.00 | 9.76 | 35 | 116644 | 1412 | 56173976 |
Blister | 53.96 | 9.76 | 89 | 116590 | 108798 | 56066590 |
Hypopyon | 53.07 | 9.76 | 27 | 116652 | 682 | 56174706 |
Electrocardiogram ST segment depression | 52.58 | 9.76 | 44 | 116635 | 2639 | 56172749 |
Lower respiratory tract infection | 52.21 | 9.76 | 99 | 116580 | 114695 | 56060693 |
Staphylococcal infection | 52.00 | 9.76 | 184 | 116495 | 37434 | 56137954 |
Generalised tonic-clonic seizure | 51.95 | 9.76 | 150 | 116529 | 27416 | 56147972 |
Inappropriate schedule of product administration | 51.90 | 9.76 | 323 | 116356 | 83064 | 56092324 |
Haemodynamic instability | 50.98 | 9.76 | 74 | 116605 | 8255 | 56167133 |
Mobility decreased | 50.85 | 9.76 | 79 | 116600 | 98912 | 56076476 |
Insurance issue | 50.38 | 9.76 | 50 | 116629 | 3742 | 56171646 |
Infusion site irritation | 50.35 | 9.76 | 26 | 116653 | 678 | 56174710 |
Decreased appetite | 49.97 | 9.76 | 259 | 116420 | 218972 | 55956416 |
Body tinea | 49.71 | 9.76 | 33 | 116646 | 1387 | 56174001 |
Cataract operation complication | 49.26 | 9.76 | 16 | 116663 | 117 | 56175271 |
Extradural abscess | 48.91 | 9.76 | 27 | 116652 | 808 | 56174580 |
Emotional distress | 48.61 | 9.76 | 154 | 116525 | 29609 | 56145779 |
Lip swelling | 48.59 | 9.76 | 142 | 116537 | 26130 | 56149258 |
C-reactive protein increased | 48.36 | 9.76 | 55 | 116624 | 78629 | 56096759 |
Kidney infection | 48.33 | 9.76 | 122 | 116557 | 20603 | 56154785 |
C-reactive protein abnormal | 48.08 | 9.76 | 9 | 116670 | 36800 | 56138588 |
Blood cholesterol increased | 47.65 | 9.76 | 48 | 116631 | 72531 | 56102857 |
Liver injury | 47.23 | 9.76 | 14 | 116665 | 41834 | 56133554 |
Tryptase increased | 47.12 | 9.76 | 20 | 116659 | 329 | 56175059 |
Circulatory collapse | 47.00 | 9.76 | 121 | 116558 | 20682 | 56154706 |
Procedural hypotension | 45.76 | 9.76 | 29 | 116650 | 1125 | 56174263 |
Fungal infection | 45.28 | 9.76 | 161 | 116518 | 32832 | 56142556 |
Post procedural complication | 44.97 | 9.76 | 100 | 116579 | 15566 | 56159822 |
Vasoplegia syndrome | 44.48 | 9.76 | 30 | 116649 | 1295 | 56174093 |
Stomatitis | 44.46 | 9.76 | 117 | 116562 | 120693 | 56054695 |
Chills | 43.85 | 9.76 | 363 | 116316 | 102241 | 56073147 |
Psoriasis | 42.97 | 9.76 | 79 | 116600 | 92613 | 56082775 |
Pharyngeal oedema | 42.96 | 9.76 | 89 | 116590 | 13196 | 56162192 |
Ventricular hypokinesia | 42.65 | 9.76 | 48 | 116631 | 4153 | 56171235 |
Pulmonary oedema | 42.39 | 9.76 | 214 | 116465 | 50929 | 56124459 |
Infusion site discomfort | 41.97 | 9.76 | 27 | 116652 | 1075 | 56174313 |
Anaesthetic complication neurological | 41.96 | 9.76 | 16 | 116663 | 196 | 56175192 |
Status asthmaticus | 41.52 | 9.76 | 25 | 116654 | 884 | 56174504 |
Blood pressure decreased | 40.75 | 9.76 | 235 | 116444 | 58815 | 56116573 |
Intentional self-injury | 40.27 | 9.76 | 3 | 116676 | 24989 | 56150399 |
Wrong product administered | 40.09 | 9.76 | 54 | 116625 | 5618 | 56169770 |
Infusion site reaction | 39.97 | 9.76 | 39 | 116640 | 2859 | 56172529 |
Extradural haematoma | 39.39 | 9.76 | 30 | 116649 | 1570 | 56173818 |
Peripheral swelling | 38.77 | 9.76 | 306 | 116373 | 234420 | 55940968 |
Eye infection | 38.39 | 9.76 | 73 | 116606 | 10171 | 56165217 |
Anaemia | 37.86 | 9.76 | 363 | 116316 | 267148 | 55908240 |
Swollen tongue | 37.43 | 9.76 | 143 | 116536 | 30181 | 56145207 |
Seizure | 36.77 | 9.76 | 409 | 116270 | 124710 | 56050678 |
Vitritis | 35.75 | 9.76 | 23 | 116656 | 916 | 56174472 |
Blood creatinine increased | 35.72 | 9.76 | 70 | 116609 | 80121 | 56095267 |
Disease progression | 35.62 | 9.76 | 106 | 116573 | 105067 | 56070321 |
Laryngeal oedema | 35.19 | 9.76 | 49 | 116630 | 5261 | 56170127 |
Hypoaesthesia oral | 35.13 | 9.76 | 75 | 116604 | 11356 | 56164032 |
Cystitis | 35.04 | 9.76 | 197 | 116482 | 48841 | 56126547 |
Pancytopenia | 34.90 | 9.76 | 83 | 116596 | 88632 | 56086756 |
Abortion spontaneous | 34.80 | 9.76 | 24 | 116655 | 43729 | 56131659 |
Multiple allergies | 34.75 | 9.76 | 71 | 116608 | 10425 | 56164963 |
Dermatitis contact | 34.61 | 9.76 | 67 | 116612 | 9460 | 56165928 |
Troponin I increased | 34.46 | 9.76 | 31 | 116648 | 2050 | 56173338 |
Injection site injury | 34.41 | 9.76 | 19 | 116660 | 569 | 56174819 |
Administration site reaction | 34.28 | 9.76 | 14 | 116665 | 208 | 56175180 |
Administration site pruritus | 34.26 | 9.76 | 15 | 116664 | 267 | 56175121 |
Procedural complication | 34.20 | 9.76 | 47 | 116632 | 4984 | 56170404 |
Removal of foreign body | 34.14 | 9.76 | 8 | 116671 | 12 | 56175376 |
Embolia cutis medicamentosa | 34.01 | 9.76 | 16 | 116663 | 339 | 56175049 |
Infection susceptibility increased | 33.88 | 9.76 | 35 | 116644 | 2748 | 56172640 |
Unresponsive to stimuli | 33.88 | 9.76 | 143 | 116536 | 31582 | 56143806 |
Irritable bowel syndrome | 33.86 | 9.76 | 56 | 116623 | 68402 | 56106986 |
Anaphylactoid reaction | 33.80 | 9.76 | 39 | 116640 | 3467 | 56171921 |
Condition aggravated | 33.52 | 9.76 | 508 | 116171 | 344390 | 55830998 |
Platelet aggregation inhibition | 33.30 | 9.76 | 12 | 116667 | 124 | 56175264 |
Inhibitory drug interaction | 33.18 | 9.76 | 32 | 116647 | 2312 | 56173076 |
Malignant neoplasm progression | 32.98 | 9.76 | 64 | 116615 | 73523 | 56101865 |
Hyperaesthesia | 32.83 | 9.76 | 62 | 116617 | 8595 | 56166793 |
Chest discomfort | 32.71 | 9.76 | 331 | 116348 | 98526 | 56076862 |
Injury | 32.46 | 9.76 | 224 | 116455 | 59627 | 56115761 |
Nerve root injury | 32.42 | 9.76 | 9 | 116670 | 35 | 56175353 |
Loss of personal independence in daily activities | 32.11 | 9.76 | 76 | 116603 | 81293 | 56094095 |
Ophthalmoplegia | 31.85 | 9.76 | 25 | 116654 | 1368 | 56174020 |
Product contamination microbial | 31.53 | 9.76 | 13 | 116666 | 198 | 56175190 |
Leukopenia | 31.53 | 9.76 | 62 | 116617 | 70878 | 56104510 |
Injection site hypoaesthesia | 31.52 | 9.76 | 16 | 116663 | 402 | 56174986 |
Administration site bruise | 31.37 | 9.76 | 15 | 116664 | 330 | 56175058 |
Throat tightness | 31.31 | 9.76 | 110 | 116569 | 22297 | 56153091 |
Sinus tachycardia | 31.20 | 9.76 | 110 | 116569 | 22334 | 56153054 |
Pharyngitis streptococcal | 31.15 | 9.76 | 64 | 116615 | 9434 | 56165954 |
Thrombocytopenia | 30.98 | 9.76 | 161 | 116518 | 136063 | 56039325 |
Drug reaction with eosinophilia and systemic symptoms | 30.96 | 9.76 | 12 | 116667 | 30292 | 56145096 |
Anterior chamber cell | 30.94 | 9.76 | 17 | 116662 | 504 | 56174884 |
Gastroenteritis viral | 30.93 | 9.76 | 103 | 116576 | 20321 | 56155067 |
Injection site coldness | 30.45 | 9.76 | 10 | 116669 | 76 | 56175312 |
Infusion site warmth | 30.23 | 9.76 | 25 | 116654 | 1475 | 56173913 |
Administration site extravasation | 29.89 | 9.76 | 19 | 116660 | 741 | 56174647 |
Type I hypersensitivity | 29.87 | 9.76 | 31 | 116648 | 2447 | 56172941 |
Pharyngeal swelling | 29.41 | 9.76 | 45 | 116634 | 5261 | 56170127 |
Asthenia | 29.40 | 9.76 | 517 | 116162 | 342456 | 55832932 |
Uterine hypertonus | 29.36 | 9.76 | 14 | 116665 | 306 | 56175082 |
Nerve block | 29.36 | 9.76 | 18 | 116661 | 658 | 56174730 |
Phrenic nerve paralysis | 29.34 | 9.76 | 12 | 116667 | 179 | 56175209 |
Anxiety | 29.05 | 9.76 | 562 | 116117 | 192610 | 55982778 |
Drug ineffective for unapproved indication | 28.36 | 9.76 | 117 | 116562 | 25576 | 56149812 |
Neuromuscular block prolonged | 28.33 | 9.76 | 16 | 116663 | 501 | 56174887 |
Bladder prolapse | 28.31 | 9.76 | 27 | 116652 | 1924 | 56173464 |
Fear of eating | 28.05 | 9.76 | 14 | 116665 | 339 | 56175049 |
Liver function test abnormal | 27.97 | 9.76 | 32 | 116647 | 45639 | 56129749 |
Myocardial ischaemia | 27.91 | 9.76 | 71 | 116608 | 12045 | 56163343 |
Death | 27.90 | 9.76 | 519 | 116160 | 340907 | 55834481 |
Cyanosis | 27.85 | 9.76 | 84 | 116595 | 15726 | 56159662 |
Mydriasis | 27.75 | 9.76 | 67 | 116612 | 11004 | 56164384 |
Paraplegia | 27.70 | 9.76 | 30 | 116649 | 2487 | 56172901 |
Vasospasm | 27.54 | 9.76 | 17 | 116662 | 629 | 56174759 |
Aqueous fibrin | 27.45 | 9.76 | 9 | 116670 | 68 | 56175320 |
Poor venous access | 27.20 | 9.76 | 71 | 116608 | 12235 | 56163153 |
Stress | 27.10 | 9.76 | 212 | 116467 | 58698 | 56116690 |
Tooth infection | 27.10 | 9.76 | 83 | 116596 | 15669 | 56159719 |
Skin infection | 27.02 | 9.76 | 74 | 116605 | 13121 | 56162267 |
Cholestasis | 26.93 | 9.76 | 11 | 116668 | 26902 | 56148486 |
Gas gangrene | 26.79 | 9.76 | 10 | 116669 | 115 | 56175273 |
Sinus disorder | 26.60 | 9.76 | 99 | 116580 | 20635 | 56154753 |
Bursitis infective | 26.42 | 9.76 | 22 | 116657 | 1310 | 56174078 |
Ventricular extrasystoles | 26.41 | 9.76 | 65 | 116614 | 10805 | 56164583 |
Paralysis | 26.31 | 9.76 | 58 | 116621 | 8974 | 56166414 |
Hepatotoxicity | 26.26 | 9.76 | 16 | 116663 | 31137 | 56144251 |
Blood pH decreased | 26.18 | 9.76 | 29 | 116650 | 2465 | 56172923 |
Peripheral nerve injury | 26.08 | 9.76 | 14 | 116665 | 396 | 56174992 |
Meningitis chemical | 26.04 | 9.76 | 10 | 116669 | 125 | 56175263 |
Drug abuse | 26.00 | 9.76 | 64 | 116615 | 67546 | 56107842 |
Hip arthroplasty | 25.97 | 9.76 | 25 | 116654 | 38598 | 56136790 |
Bundle branch block left | 25.93 | 9.76 | 47 | 116632 | 6315 | 56169073 |
Anaphylactoid shock | 25.86 | 9.76 | 13 | 116666 | 320 | 56175068 |
Adverse event | 25.84 | 9.76 | 47 | 116632 | 55329 | 56120059 |
Corneal epithelium defect | 25.67 | 9.76 | 13 | 116666 | 325 | 56175063 |
Red blood cell sedimentation rate increased | 25.46 | 9.76 | 23 | 116656 | 36600 | 56138788 |
Sinus operation | 25.37 | 9.76 | 26 | 116653 | 2022 | 56173366 |
PO2 decreased | 25.29 | 9.76 | 22 | 116657 | 1391 | 56173997 |
Wheezing | 25.20 | 9.76 | 252 | 116427 | 74774 | 56100614 |
Pneumocephalus | 25.15 | 9.76 | 10 | 116669 | 138 | 56175250 |
Spinal stroke | 25.06 | 9.76 | 7 | 116672 | 28 | 56175360 |
Abdominal pain upper | 24.76 | 9.76 | 243 | 116436 | 178070 | 55997318 |
Influenza like illness | 24.58 | 9.76 | 213 | 116466 | 60775 | 56114613 |
Tracheal deviation | 24.52 | 9.76 | 10 | 116669 | 148 | 56175240 |
Limb injury | 24.26 | 9.76 | 101 | 116578 | 22169 | 56153219 |
Eyelid rash | 24.23 | 9.76 | 9 | 116670 | 102 | 56175286 |
Axillary nerve injury | 24.20 | 9.76 | 6 | 116673 | 13 | 56175375 |
Glucose tolerance impaired | 24.15 | 9.76 | 42 | 116637 | 5463 | 56169925 |
Myopathy toxic | 23.96 | 9.76 | 14 | 116665 | 468 | 56174920 |
Rectal prolapse | 23.59 | 9.76 | 24 | 116655 | 1850 | 56173538 |
Parophthalmia | 23.45 | 9.76 | 12 | 116667 | 307 | 56175081 |
Upper airway obstruction | 23.35 | 9.76 | 15 | 116664 | 596 | 56174792 |
Systemic toxicity | 23.32 | 9.76 | 7 | 116672 | 38 | 56175350 |
Cardiac failure congestive | 23.28 | 9.76 | 98 | 116581 | 87622 | 56087766 |
Respiratory acidosis | 23.20 | 9.76 | 44 | 116635 | 6119 | 56169269 |
Drug resistance | 22.95 | 9.76 | 7 | 116672 | 20535 | 56154853 |
Orthostatic hypotension | 22.90 | 9.76 | 21 | 116658 | 33178 | 56142210 |
Septic arthritis staphylococcal | 22.85 | 9.76 | 13 | 116666 | 413 | 56174975 |
Heart rate increased | 22.56 | 9.76 | 268 | 116411 | 83005 | 56092383 |
Troponin T increased | 22.36 | 9.76 | 18 | 116661 | 1022 | 56174366 |
Retinal vasculitis | 22.35 | 9.76 | 17 | 116662 | 888 | 56174500 |
Multiple organ dysfunction syndrome | 22.16 | 9.76 | 186 | 116493 | 52584 | 56122804 |
Device infusion issue | 22.13 | 9.76 | 22 | 116657 | 1650 | 56173738 |
Cranial nerve palsies multiple | 22.11 | 9.76 | 6 | 116673 | 21 | 56175367 |
Osteonecrosis of jaw | 21.96 | 9.76 | 22 | 116657 | 33336 | 56142052 |
Trigemino-cardiac reflex | 21.94 | 9.76 | 7 | 116672 | 48 | 56175340 |
Supraventricular tachycardia | 21.91 | 9.76 | 69 | 116610 | 13222 | 56162166 |
Retinal artery occlusion | 21.78 | 9.76 | 21 | 116658 | 1517 | 56173871 |
Infusion site discolouration | 21.59 | 9.76 | 15 | 116664 | 680 | 56174708 |
Immunisation reaction | 21.51 | 9.76 | 11 | 116668 | 281 | 56175107 |
Prescribed underdose | 21.34 | 9.76 | 8 | 116671 | 20609 | 56154779 |
Device expulsion | 21.31 | 9.76 | 19 | 116660 | 30430 | 56144958 |
Spinal operation | 21.16 | 9.76 | 47 | 116632 | 7309 | 56168079 |
Spinal epidural haemorrhage | 20.69 | 9.76 | 8 | 116671 | 102 | 56175286 |
Arterial spasm | 20.68 | 9.76 | 7 | 116672 | 59 | 56175329 |
PCO2 increased | 20.53 | 9.76 | 18 | 116661 | 1150 | 56174238 |
Liver disorder | 20.39 | 9.76 | 38 | 116641 | 44332 | 56131056 |
Inflammation | 20.35 | 9.76 | 74 | 116605 | 68997 | 56106391 |
Vitamin D increased | 20.32 | 9.76 | 14 | 116665 | 626 | 56174762 |
Sleep disorder | 20.26 | 9.76 | 72 | 116607 | 67591 | 56107797 |
Paraesthesia oral | 20.24 | 9.76 | 71 | 116608 | 14378 | 56161010 |
Sensory loss | 20.21 | 9.76 | 52 | 116627 | 8883 | 56166505 |
Lung hyperinflation | 20.14 | 9.76 | 18 | 116661 | 1180 | 56174208 |
Postresuscitation encephalopathy | 20.11 | 9.76 | 5 | 116674 | 11 | 56175377 |
Local reaction | 20.10 | 9.76 | 14 | 116665 | 637 | 56174751 |
Blood lactic acid increased | 20.05 | 9.76 | 41 | 116638 | 6023 | 56169365 |
Nystagmus | 19.99 | 9.76 | 40 | 116639 | 5785 | 56169603 |
White blood cell count decreased | 19.97 | 9.76 | 166 | 116513 | 125824 | 56049564 |
Rash | 19.86 | 9.76 | 828 | 115851 | 492219 | 55683169 |
Oral herpes | 19.82 | 9.76 | 97 | 116582 | 22793 | 56152595 |
Electrocardiogram T wave inversion | 19.45 | 9.76 | 29 | 116650 | 3314 | 56172074 |
Injection site pain | 19.42 | 9.76 | 346 | 116333 | 116772 | 56058616 |
Inability to afford medication | 19.36 | 9.76 | 21 | 116658 | 1744 | 56173644 |
Administration site nodule | 19.35 | 9.76 | 6 | 116673 | 37 | 56175351 |
Fear of death | 19.31 | 9.76 | 16 | 116663 | 946 | 56174442 |
Administration site irritation | 19.21 | 9.76 | 6 | 116673 | 38 | 56175350 |
Apnoeic attack | 19.12 | 9.76 | 10 | 116669 | 268 | 56175120 |
Blood pressure increased | 19.05 | 9.76 | 414 | 116265 | 144762 | 56030626 |
Therapy interrupted | 19.01 | 9.76 | 104 | 116575 | 25521 | 56149867 |
Injection site inflammation | 18.97 | 9.76 | 29 | 116650 | 3387 | 56172001 |
Reversible cerebral vasoconstriction syndrome | 18.93 | 9.76 | 24 | 116655 | 2353 | 56173035 |
Poor quality sleep | 18.93 | 9.76 | 80 | 116599 | 17675 | 56157713 |
Anal skin tags | 18.92 | 9.76 | 12 | 116667 | 466 | 56174922 |
Hypocalcaemia | 18.89 | 9.76 | 19 | 116660 | 28741 | 56146647 |
Administration site haemorrhage | 18.72 | 9.76 | 7 | 116672 | 81 | 56175307 |
Harlequin syndrome | 18.70 | 9.76 | 6 | 116673 | 42 | 56175346 |
Infusion site scar | 18.60 | 9.76 | 11 | 116668 | 376 | 56175012 |
Meningitis aseptic | 18.57 | 9.76 | 33 | 116646 | 4366 | 56171022 |
Atonic urinary bladder | 18.56 | 9.76 | 7 | 116672 | 83 | 56175305 |
Knee arthroplasty | 18.55 | 9.76 | 40 | 116639 | 44219 | 56131169 |
Gastrointestinal disorder | 18.55 | 9.76 | 147 | 116532 | 112555 | 56062833 |
Therapeutic product effect incomplete | 18.53 | 9.76 | 136 | 116543 | 105895 | 56069493 |
No adverse event | 18.47 | 9.76 | 134 | 116545 | 36240 | 56139148 |
Spinal anaesthesia | 18.46 | 9.76 | 6 | 116673 | 44 | 56175344 |
Administration site discolouration | 18.34 | 9.76 | 6 | 116673 | 45 | 56175343 |
Ischaemia | 18.33 | 9.76 | 33 | 116646 | 4410 | 56170978 |
Vocal cord dysfunction | 18.27 | 9.76 | 11 | 116668 | 389 | 56174999 |
Product adhesion issue | 18.12 | 9.76 | 33 | 116646 | 4450 | 56170938 |
Creatinine renal clearance decreased | 18.10 | 9.76 | 4 | 116675 | 14555 | 56160833 |
Eyelid ptosis | 18.03 | 9.76 | 41 | 116638 | 6478 | 56168910 |
Hepatocellular injury | 18.02 | 9.76 | 17 | 116662 | 26497 | 56148891 |
Neurogenic shock | 17.94 | 9.76 | 10 | 116669 | 305 | 56175083 |
Accidental overdose | 17.93 | 9.76 | 87 | 116592 | 20374 | 56155014 |
Infusion site induration | 17.90 | 9.76 | 15 | 116664 | 901 | 56174487 |
Mean arterial pressure decreased | 17.85 | 9.76 | 8 | 116671 | 151 | 56175237 |
Loss of consciousness | 17.76 | 9.76 | 322 | 116357 | 109027 | 56066361 |
Constipation | 17.73 | 9.76 | 303 | 116376 | 201640 | 55973748 |
Vasoconstriction | 17.65 | 9.76 | 12 | 116667 | 525 | 56174863 |
Interstitial lung disease | 17.57 | 9.76 | 60 | 116619 | 57003 | 56118385 |
Conjunctival oedema | 17.55 | 9.76 | 13 | 116666 | 652 | 56174736 |
Ill-defined disorder | 17.32 | 9.76 | 78 | 116601 | 68465 | 56106923 |
Enzyme induction | 17.19 | 9.76 | 6 | 116673 | 56 | 56175332 |
Systolic anterior motion of mitral valve | 17.17 | 9.76 | 5 | 116674 | 24 | 56175364 |
Off label use | 17.09 | 9.76 | 961 | 115718 | 555219 | 55620169 |
Spinal cord infarction | 17.08 | 9.76 | 9 | 116670 | 245 | 56175143 |
Product measured potency issue | 17.08 | 9.76 | 7 | 116672 | 105 | 56175283 |
Punctate keratitis | 17.06 | 9.76 | 12 | 116667 | 555 | 56174833 |
Neoplasm progression | 16.96 | 9.76 | 25 | 116654 | 31991 | 56143397 |
Respiratory distress | 16.86 | 9.76 | 118 | 116561 | 31549 | 56143839 |
Jaundice | 16.85 | 9.76 | 19 | 116660 | 27275 | 56148113 |
Urticaria chronic | 16.72 | 9.76 | 12 | 116667 | 573 | 56174815 |
Influenza | 16.71 | 9.76 | 284 | 116395 | 94977 | 56080411 |
Propofol infusion syndrome | 16.71 | 9.76 | 14 | 116665 | 841 | 56174547 |
Food allergy | 16.61 | 9.76 | 48 | 116631 | 8776 | 56166612 |
Extremity necrosis | 16.54 | 9.76 | 18 | 116661 | 1500 | 56173888 |
Glossoptosis | 16.48 | 9.76 | 6 | 116673 | 64 | 56175324 |
Respiratory depression | 16.48 | 9.76 | 60 | 116619 | 12375 | 56163013 |
Hepatic cirrhosis | 16.47 | 9.76 | 12 | 116667 | 21251 | 56154137 |
Central venous catheterisation | 16.41 | 9.76 | 23 | 116656 | 2484 | 56172904 |
Device ineffective | 16.29 | 9.76 | 8 | 116671 | 187 | 56175201 |
ECG signs of myocardial ischaemia | 16.15 | 9.76 | 6 | 116673 | 68 | 56175320 |
Gastric infection | 16.13 | 9.76 | 26 | 116653 | 3178 | 56172210 |
Arachnoiditis | 16.07 | 9.76 | 9 | 116670 | 277 | 56175111 |
Hypomagnesaemia | 15.90 | 9.76 | 17 | 116662 | 24998 | 56150390 |
Muscle tightness | 15.84 | 9.76 | 54 | 116625 | 10782 | 56164606 |
Viral infection | 15.83 | 9.76 | 117 | 116562 | 31829 | 56143559 |
Obesity | 15.72 | 9.76 | 14 | 116665 | 22434 | 56152954 |
Distributive shock | 15.64 | 9.76 | 15 | 116664 | 1076 | 56174312 |
Abdominal pain | 15.50 | 9.76 | 413 | 116266 | 258392 | 55916996 |
Brain injury | 15.44 | 9.76 | 38 | 116641 | 6317 | 56169071 |
Normal newborn | 15.40 | 9.76 | 42 | 116637 | 7428 | 56167960 |
Platelet count decreased | 15.17 | 9.76 | 144 | 116535 | 106239 | 56069149 |
Eye infarction | 15.00 | 9.76 | 5 | 116674 | 40 | 56175348 |
Mast cell activation syndrome | 14.93 | 9.76 | 12 | 116667 | 680 | 56174708 |
Therapeutic product effect prolonged | 14.88 | 9.76 | 9 | 116670 | 321 | 56175067 |
Diplegia | 14.88 | 9.76 | 14 | 116665 | 981 | 56174407 |
Meningitis | 14.86 | 9.76 | 38 | 116641 | 6466 | 56168922 |
Product distribution issue | 14.84 | 9.76 | 14 | 116665 | 984 | 56174404 |
Accidental exposure to product by child | 14.73 | 9.76 | 15 | 116664 | 1158 | 56174230 |
Cold sweat | 14.67 | 9.76 | 53 | 116626 | 10890 | 56164498 |
Neuroleptic malignant syndrome | 14.58 | 9.76 | 3 | 116676 | 11475 | 56163913 |
Osteoarthritis | 14.51 | 9.76 | 102 | 116577 | 80194 | 56095194 |
Blindness | 14.50 | 9.76 | 76 | 116603 | 18345 | 56157043 |
Cardiac assistance device user | 14.49 | 9.76 | 5 | 116674 | 45 | 56175343 |
Metastases to liver | 14.48 | 9.76 | 14 | 116665 | 21572 | 56153816 |
Gastrointestinal haemorrhage | 14.46 | 9.76 | 95 | 116584 | 75856 | 56099532 |
Status epilepticus | 14.45 | 9.76 | 66 | 116613 | 15075 | 56160313 |
Plasma cell myeloma | 14.39 | 9.76 | 49 | 116630 | 46597 | 56128791 |
Administration site scar | 14.39 | 9.76 | 5 | 116674 | 46 | 56175342 |
Postpartum disorder | 14.32 | 9.76 | 4 | 116675 | 16 | 56175372 |
Hypercalcaemia | 14.30 | 9.76 | 19 | 116660 | 25392 | 56149996 |
Product availability issue | 14.23 | 9.76 | 24 | 116655 | 3045 | 56172343 |
Drug tolerance decreased | 14.22 | 9.76 | 5 | 116674 | 13406 | 56161982 |
Apnoea | 14.22 | 9.76 | 40 | 116639 | 7202 | 56168186 |
Pneumonia mycoplasmal | 14.20 | 9.76 | 13 | 116666 | 879 | 56174509 |
Animal bite | 14.19 | 9.76 | 22 | 116657 | 2601 | 56172787 |
Haematochezia | 14.13 | 9.76 | 45 | 116634 | 43673 | 56131715 |
Respiratory tract oedema | 14.09 | 9.76 | 10 | 116669 | 469 | 56174919 |
Spinal epidural haematoma | 14.05 | 9.76 | 14 | 116665 | 1053 | 56174335 |
Scar | 14.02 | 9.76 | 57 | 116622 | 12376 | 56163012 |
Gastroenteritis | 14 | 9.76 | 18 | 116661 | 24394 | 56150994 |
Tongue pruritus | 14.00 | 9.76 | 10 | 116669 | 474 | 56174914 |
Visual acuity reduced | 13.98 | 9.76 | 82 | 116597 | 20644 | 56154744 |
Delayed recovery from anaesthesia | 13.97 | 9.76 | 12 | 116667 | 746 | 56174642 |
Injection site extravasation | 13.96 | 9.76 | 43 | 116636 | 8141 | 56167247 |
Rotator cuff syndrome | 13.96 | 9.76 | 56 | 116623 | 12087 | 56163301 |
Neutropenic sepsis | 13.95 | 9.76 | 7 | 116672 | 15178 | 56160210 |
Inadequate analgesia | 13.89 | 9.76 | 22 | 116657 | 2649 | 56172739 |
Paranasal cyst | 13.89 | 9.76 | 9 | 116670 | 363 | 56175025 |
Epidural analgesia | 13.85 | 9.76 | 5 | 116674 | 52 | 56175336 |
Hallucination, tactile | 13.84 | 9.76 | 8 | 116671 | 262 | 56175126 |
International normalised ratio increased | 13.77 | 9.76 | 46 | 116633 | 43995 | 56131393 |
Nail bed tenderness | 13.73 | 9.76 | 9 | 116670 | 370 | 56175018 |
Throat irritation | 13.61 | 9.76 | 115 | 116564 | 32568 | 56142820 |
Incision site rash | 13.60 | 9.76 | 4 | 116675 | 20 | 56175368 |
Forced vital capacity abnormal | 13.60 | 9.76 | 4 | 116675 | 20 | 56175368 |
Trigeminal palsy | 13.60 | 9.76 | 4 | 116675 | 20 | 56175368 |
Malabsorption from administration site | 13.54 | 9.76 | 6 | 116673 | 110 | 56175278 |
Depressed mood | 13.53 | 9.76 | 35 | 116644 | 36324 | 56139064 |
SARS-CoV-2 test false positive | 13.47 | 9.76 | 3 | 116676 | 3 | 56175385 |
Vaccination site rash | 13.44 | 9.76 | 4 | 116675 | 21 | 56175367 |
Caffeine allergy | 13.44 | 9.76 | 4 | 116675 | 21 | 56175367 |
Infusion site oedema | 13.39 | 9.76 | 11 | 116668 | 643 | 56174745 |
Diplopia | 13.36 | 9.76 | 80 | 116599 | 20289 | 56155099 |
Blood pressure immeasurable | 13.32 | 9.76 | 14 | 116665 | 1121 | 56174267 |
Chondromalacia | 13.26 | 9.76 | 8 | 116671 | 284 | 56175104 |
Colour blindness | 13.16 | 9.76 | 8 | 116671 | 288 | 56175100 |
Oedema peripheral | 13.14 | 9.76 | 263 | 116416 | 170991 | 56004397 |
Pain in extremity | 13.13 | 9.76 | 494 | 116185 | 296937 | 55878451 |
Procedural haemorrhage | 13.13 | 9.76 | 21 | 116658 | 2550 | 56172838 |
Foetal heart rate abnormal | 13.10 | 9.76 | 10 | 116669 | 525 | 56174863 |
Mastocytosis | 13.07 | 9.76 | 10 | 116669 | 527 | 56174861 |
Systolic dysfunction | 13.07 | 9.76 | 16 | 116663 | 1514 | 56173874 |
Pneumonia | 13.07 | 9.76 | 996 | 115683 | 406102 | 55769286 |
Smoke sensitivity | 13.05 | 9.76 | 9 | 116670 | 403 | 56174985 |
Femur fracture | 13.01 | 9.76 | 40 | 116639 | 39255 | 56136133 |
Myocardial necrosis marker increased | 13.01 | 9.76 | 17 | 116662 | 1717 | 56173671 |
Catheter site pain | 13.00 | 9.76 | 28 | 116651 | 4265 | 56171123 |
Spinal cord oedema | 12.98 | 9.76 | 6 | 116673 | 122 | 56175266 |
Colitis ulcerative | 12.97 | 9.76 | 19 | 116660 | 24372 | 56151016 |
Vaccination complication | 12.95 | 9.76 | 13 | 116666 | 986 | 56174402 |
Hypercapnia | 12.94 | 9.76 | 31 | 116648 | 5065 | 56170323 |
Administration site rash | 12.91 | 9.76 | 5 | 116674 | 64 | 56175324 |
Gastric mucosa erythema | 12.82 | 9.76 | 8 | 116671 | 302 | 56175086 |
Arthritis bacterial | 12.77 | 9.76 | 34 | 116645 | 5927 | 56169461 |
Peritonitis | 12.73 | 9.76 | 9 | 116670 | 16193 | 56159195 |
Vascular stenosis | 12.70 | 9.76 | 8 | 116671 | 307 | 56175081 |
Procedural anxiety | 12.68 | 9.76 | 11 | 116668 | 693 | 56174695 |
Device issue | 12.65 | 9.76 | 81 | 116598 | 21025 | 56154363 |
Bacterial infection | 12.63 | 9.76 | 70 | 116609 | 17260 | 56158128 |
Left ventricular dysfunction | 12.55 | 9.76 | 51 | 116628 | 11072 | 56164316 |
CSF pressure increased | 12.55 | 9.76 | 6 | 116673 | 132 | 56175256 |
Depression | 12.53 | 9.76 | 281 | 116398 | 179836 | 55995552 |
Joint stiffness | 12.50 | 9.76 | 35 | 116644 | 35390 | 56139998 |
Thermal burn | 12.49 | 9.76 | 32 | 116647 | 5453 | 56169935 |
Quadriparesis | 12.48 | 9.76 | 17 | 116662 | 1787 | 56173601 |
Alanine aminotransferase increased | 12.43 | 9.76 | 129 | 116550 | 93533 | 56081855 |
Musculoskeletal pain | 12.37 | 9.76 | 108 | 116571 | 81044 | 56094344 |
Administration site mass | 12.34 | 9.76 | 4 | 116675 | 29 | 56175359 |
Product contamination | 12.33 | 9.76 | 10 | 116669 | 574 | 56174814 |
Disease recurrence | 12.28 | 9.76 | 19 | 116660 | 23841 | 56151547 |
Maternal exposure during pregnancy | 12.28 | 9.76 | 299 | 116380 | 189254 | 55986134 |
Oropharyngeal discomfort | 12.24 | 9.76 | 28 | 116651 | 4440 | 56170948 |
Suicide attempt | 12.23 | 9.76 | 70 | 116609 | 57766 | 56117622 |
Metabolic acidosis | 12.22 | 9.76 | 133 | 116546 | 40321 | 56135067 |
Irregular breathing | 12.21 | 9.76 | 8 | 116671 | 329 | 56175059 |
Eye inflammation | 12.17 | 9.76 | 29 | 116650 | 4722 | 56170666 |
Anal sphincter atony | 12.14 | 9.76 | 7 | 116672 | 228 | 56175160 |
Sinus bradycardia | 12.07 | 9.76 | 58 | 116621 | 13528 | 56161860 |
Autonomic neuropathy | 12.06 | 9.76 | 13 | 116666 | 1072 | 56174316 |
Transaminases increased | 12.06 | 9.76 | 26 | 116653 | 28744 | 56146644 |
Nasal discharge discolouration | 12.03 | 9.76 | 17 | 116662 | 1850 | 56173538 |
Streptococcal infection | 11.96 | 9.76 | 30 | 116649 | 5045 | 56170343 |
Hypoxia | 11.87 | 9.76 | 167 | 116512 | 53730 | 56121658 |
Product contamination physical | 11.85 | 9.76 | 5 | 116674 | 81 | 56175307 |
Ehlers-Danlos syndrome | 11.85 | 9.76 | 6 | 116673 | 150 | 56175238 |
Pupil fixed | 11.81 | 9.76 | 16 | 116663 | 1674 | 56173714 |
Hepatitis | 11.79 | 9.76 | 36 | 116643 | 35405 | 56139983 |
Heart rate decreased | 11.79 | 9.76 | 132 | 116547 | 40295 | 56135093 |
Overdose | 11.78 | 9.76 | 295 | 116384 | 105535 | 56069853 |
Product administration error | 11.74 | 9.76 | 79 | 116600 | 20850 | 56154538 |
Pain in jaw | 11.72 | 9.76 | 43 | 116636 | 39993 | 56135395 |
Post procedural infection | 11.72 | 9.76 | 41 | 116638 | 8291 | 56167097 |
Post-anoxic myoclonus | 11.69 | 9.76 | 4 | 116675 | 35 | 56175353 |
Cutis laxa | 11.67 | 9.76 | 6 | 116673 | 155 | 56175233 |
Balance disorder | 11.59 | 9.76 | 102 | 116577 | 76418 | 56098970 |
Melaena | 11.50 | 9.76 | 26 | 116653 | 28264 | 56147124 |
Propionibacterium infection | 11.49 | 9.76 | 4 | 116675 | 37 | 56175351 |
Genital ulceration | 11.49 | 9.76 | 9 | 116670 | 491 | 56174897 |
Application site alopecia | 11.40 | 9.76 | 3 | 116676 | 9 | 56175379 |
Decreased ventricular preload | 11.40 | 9.76 | 3 | 116676 | 9 | 56175379 |
Injection site haemorrhage | 11.40 | 9.76 | 82 | 116597 | 22119 | 56153269 |
Malignant melanoma | 11.36 | 9.76 | 4 | 116675 | 10715 | 56164673 |
Oropharyngeal pain | 11.32 | 9.76 | 240 | 116439 | 83548 | 56091840 |
Foot deformity | 11.31 | 9.76 | 20 | 116659 | 23805 | 56151583 |
Poor quality product administered | 11.29 | 9.76 | 21 | 116658 | 2878 | 56172510 |
Blood calcium decreased | 11.24 | 9.76 | 20 | 116659 | 23749 | 56151639 |
Device use issue | 11.24 | 9.76 | 18 | 116661 | 2188 | 56173200 |
Electrocardiogram U wave present | 11.22 | 9.76 | 5 | 116674 | 93 | 56175295 |
Mental status changes | 11.19 | 9.76 | 123 | 116556 | 37378 | 56138010 |
XIIth nerve injury | 11.17 | 9.76 | 3 | 116676 | 10 | 56175378 |
Cholestasis of pregnancy | 11.16 | 9.76 | 13 | 116666 | 1168 | 56174220 |
Capillary nail refill test abnormal | 11.13 | 9.76 | 4 | 116675 | 41 | 56175347 |
Hypoxic-ischaemic encephalopathy | 11.12 | 9.76 | 25 | 116654 | 3920 | 56171468 |
Cardiac arrest neonatal | 11.08 | 9.76 | 5 | 116674 | 96 | 56175292 |
Orbital infection | 11.04 | 9.76 | 4 | 116675 | 42 | 56175346 |
Vascular resistance systemic decreased | 11.03 | 9.76 | 5 | 116674 | 97 | 56175291 |
Food poisoning | 11.02 | 9.76 | 24 | 116655 | 3682 | 56171706 |
Blood bilirubin increased | 11.01 | 9.76 | 34 | 116645 | 33320 | 56142068 |
Ventricular arrhythmia | 11.00 | 9.76 | 23 | 116656 | 3431 | 56171957 |
Urticarial vasculitis | 10.99 | 9.76 | 10 | 116669 | 671 | 56174717 |
Psychotic disorder | 10.98 | 9.76 | 20 | 116659 | 23538 | 56151850 |
Epinephrine increased | 10.94 | 9.76 | 3 | 116676 | 11 | 56175377 |
Disseminated intravascular coagulation | 10.94 | 9.76 | 69 | 116610 | 17816 | 56157572 |
SARS-CoV-2 test positive | 10.88 | 9.76 | 33 | 116646 | 6196 | 56169192 |
Breast cancer female | 10.88 | 9.76 | 6 | 116673 | 12332 | 56163056 |
Anaphylactoid syndrome of pregnancy | 10.88 | 9.76 | 4 | 116675 | 44 | 56175344 |
Lung neoplasm malignant | 10.86 | 9.76 | 12 | 116667 | 17384 | 56158004 |
Biopsy lung | 10.86 | 9.76 | 6 | 116673 | 180 | 56175208 |
Optic atrophy | 10.85 | 9.76 | 13 | 116666 | 1203 | 56174185 |
Cardio-respiratory arrest | 10.84 | 9.76 | 168 | 116511 | 55153 | 56120235 |
Bradycardia foetal | 10.81 | 9.76 | 8 | 116671 | 401 | 56174987 |
Pulmonary fibrosis | 10.80 | 9.76 | 29 | 116650 | 29729 | 56145659 |
Product leakage | 10.79 | 9.76 | 10 | 116669 | 687 | 56174701 |
Tremor | 10.79 | 9.76 | 328 | 116351 | 120761 | 56054627 |
Drug-induced liver injury | 10.77 | 9.76 | 36 | 116643 | 34426 | 56140962 |
Arthropod sting | 10.72 | 9.76 | 12 | 116667 | 1032 | 56174356 |
Cognitive disorder | 10.64 | 9.76 | 59 | 116620 | 49074 | 56126314 |
Low cardiac output syndrome | 10.63 | 9.76 | 7 | 116672 | 290 | 56175098 |
Intercepted medication error | 10.60 | 9.76 | 9 | 116670 | 551 | 56174837 |
Central venous catheter removal | 10.58 | 9.76 | 8 | 116671 | 414 | 56174974 |
Metastases to bone | 10.56 | 9.76 | 15 | 116664 | 19493 | 56155895 |
Ascites | 10.55 | 9.76 | 41 | 116638 | 37503 | 56137885 |
Victim of spousal abuse | 10.55 | 9.76 | 3 | 116676 | 13 | 56175375 |
Electrocardiogram QRS complex prolonged | 10.54 | 9.76 | 30 | 116649 | 5437 | 56169951 |
Erythema | 10.52 | 9.76 | 409 | 116270 | 155530 | 56019858 |
Lip disorder | 10.49 | 9.76 | 13 | 116666 | 1245 | 56174143 |
N-terminal prohormone brain natriuretic peptide | 10.49 | 9.76 | 4 | 116675 | 49 | 56175339 |
Right ventricular dysfunction | 10.46 | 9.76 | 15 | 116664 | 1654 | 56173734 |
Coronary artery disease | 10.45 | 9.76 | 31 | 116648 | 30765 | 56144623 |
Infected bite | 10.44 | 9.76 | 15 | 116664 | 1657 | 56173731 |
Gastrointestinal bacterial overgrowth | 10.44 | 9.76 | 9 | 116670 | 562 | 56174826 |
Ocular retrobulbar haemorrhage | 10.41 | 9.76 | 5 | 116674 | 111 | 56175277 |
Dental restoration failure | 10.40 | 9.76 | 10 | 116669 | 720 | 56174668 |
Hyperlactacidaemia | 10.39 | 9.76 | 19 | 116660 | 2569 | 56172819 |
Product use in unapproved indication | 10.38 | 9.76 | 373 | 116306 | 140449 | 56034939 |
Injection site abscess | 10.33 | 9.76 | 12 | 116667 | 1074 | 56174314 |
Laryngeal obstruction | 10.33 | 9.76 | 5 | 116674 | 113 | 56175275 |
Eosinophilia | 10.32 | 9.76 | 16 | 116663 | 20061 | 56155327 |
Corneal abrasion | 10.30 | 9.76 | 11 | 116668 | 897 | 56174491 |
Transferrin decreased | 10.23 | 9.76 | 6 | 116673 | 202 | 56175186 |
Coccygectomy | 10.20 | 9.76 | 3 | 116676 | 15 | 56175373 |
Arthritis fungal | 10.20 | 9.76 | 3 | 116676 | 15 | 56175373 |
Vitamin E decreased | 10.20 | 9.76 | 3 | 116676 | 15 | 56175373 |
Gait disturbance | 10.20 | 9.76 | 259 | 116420 | 163062 | 56012326 |
Nail bed infection bacterial | 10.20 | 9.76 | 3 | 116676 | 15 | 56175373 |
Localised infection | 10.15 | 9.76 | 94 | 116585 | 27318 | 56148070 |
Airway complication of anaesthesia | 10.12 | 9.76 | 6 | 116673 | 206 | 56175182 |
Cold urticaria | 10.07 | 9.76 | 4 | 116675 | 55 | 56175333 |
Nephrolithiasis | 10.04 | 9.76 | 120 | 116559 | 37215 | 56138173 |
Epidural haemorrhage | 10.02 | 9.76 | 5 | 116674 | 121 | 56175267 |
Weight fluctuation | 10.02 | 9.76 | 38 | 116641 | 7990 | 56167398 |
Exposure during pregnancy | 10.02 | 9.76 | 361 | 116318 | 135981 | 56039407 |
Body dysmorphic disorder | 10.00 | 9.76 | 7 | 116672 | 321 | 56175067 |
Quadriplegia | 10 | 9.76 | 15 | 116664 | 1723 | 56173665 |
Respiratory failure | 10 | 9.76 | 263 | 116416 | 94799 | 56080589 |
Electrocardiogram P wave abnormal | 9.99 | 9.76 | 6 | 116673 | 211 | 56175177 |
Gamma-glutamyltransferase increased | 9.96 | 9.76 | 32 | 116647 | 30973 | 56144415 |
Akinesia | 9.92 | 9.76 | 14 | 116665 | 1522 | 56173866 |
Tubulointerstitial nephritis | 9.86 | 9.76 | 12 | 116667 | 16653 | 56158735 |
Rhabdomyolysis | 9.84 | 9.76 | 47 | 116632 | 40611 | 56134777 |
Sedation complication | 9.83 | 9.76 | 6 | 116673 | 11666 | 56163722 |
Vocal cord disorder | 9.82 | 9.76 | 13 | 116666 | 1330 | 56174058 |
Weight increased | 9.80 | 9.76 | 383 | 116296 | 229320 | 55946068 |
Atrioventricular block complete | 9.79 | 9.76 | 36 | 116643 | 7458 | 56167930 |
Hyposmia | 9.79 | 9.76 | 9 | 116670 | 612 | 56174776 |
Circumstance or information capable of leading to device use error | 9.77 | 9.76 | 5 | 116674 | 128 | 56175260 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic reaction | 419.86 | 10.53 | 391 | 60743 | 29162 | 31607048 |
Device failure | 369.36 | 10.53 | 143 | 60991 | 1980 | 31634230 |
Sinusitis | 315.15 | 10.53 | 371 | 60763 | 36325 | 31599885 |
Drug ineffective | 272.64 | 10.53 | 1487 | 59647 | 394086 | 31242124 |
Cardiac arrest | 272.43 | 10.53 | 558 | 60576 | 88504 | 31547706 |
Anaesthetic complication | 251.11 | 10.53 | 89 | 61045 | 945 | 31635265 |
Anaphylactic shock | 248.19 | 10.53 | 211 | 60923 | 13934 | 31622276 |
Toxic anterior segment syndrome | 192.93 | 10.53 | 75 | 61059 | 1050 | 31635160 |
Chondrolysis | 157.36 | 10.53 | 38 | 61096 | 78 | 31636132 |
Fear | 157.23 | 10.53 | 140 | 60994 | 9834 | 31626376 |
Ventricular tachycardia | 156.13 | 10.53 | 210 | 60924 | 23491 | 31612719 |
Injury | 153.93 | 10.53 | 190 | 60944 | 19519 | 31616691 |
Methaemoglobinaemia | 151.78 | 10.53 | 86 | 61048 | 2920 | 31633290 |
Local anaesthetic systemic toxicity | 146.62 | 10.53 | 42 | 61092 | 205 | 31636005 |
Hypotension | 144.55 | 10.53 | 776 | 60358 | 203842 | 31432368 |
Hereditary angioedema | 142.65 | 10.53 | 59 | 61075 | 979 | 31635231 |
Renal injury | 141.56 | 10.53 | 136 | 60998 | 10529 | 31625681 |
Stress cardiomyopathy | 120.54 | 10.53 | 62 | 61072 | 1728 | 31634482 |
Accidental exposure to product | 118.68 | 10.53 | 128 | 61006 | 11367 | 31624843 |
Ear infection | 113.64 | 10.53 | 111 | 61023 | 8770 | 31627440 |
Anhedonia | 112.44 | 10.53 | 102 | 61032 | 7340 | 31628870 |
Emotional distress | 111.45 | 10.53 | 138 | 60996 | 14218 | 31621992 |
Infusion site swelling | 110.66 | 10.53 | 62 | 61072 | 2059 | 31634151 |
Ventricular fibrillation | 106.25 | 10.53 | 155 | 60979 | 18693 | 31617517 |
Bradycardia | 102.16 | 10.53 | 330 | 60804 | 68997 | 31567213 |
Injection site pallor | 99.81 | 10.53 | 19 | 61115 | 0 | 31636210 |
Infusion site pain | 98.86 | 10.53 | 67 | 61067 | 3139 | 31633071 |
Unevaluable event | 96.14 | 10.53 | 194 | 60940 | 30381 | 31605829 |
Electrocardiogram ST segment elevation | 91.16 | 10.53 | 74 | 61060 | 4577 | 31631633 |
Needle issue | 91.12 | 10.53 | 78 | 61056 | 5195 | 31631015 |
Injection site laceration | 88.23 | 10.53 | 19 | 61115 | 16 | 31636194 |
Lagophthalmos | 87.17 | 10.53 | 23 | 61111 | 77 | 31636133 |
Accidental exposure to product by child | 81.35 | 10.53 | 45 | 61089 | 1457 | 31634753 |
Product quality issue | 80.14 | 10.53 | 125 | 61009 | 15986 | 31620224 |
Drug ineffective for unapproved indication | 78.89 | 10.53 | 131 | 61003 | 17659 | 31618551 |
Diarrhoea | 77.73 | 10.53 | 383 | 60751 | 352026 | 31284184 |
Shock | 77.61 | 10.53 | 149 | 60985 | 22496 | 31613714 |
Bronchospasm | 74.43 | 10.53 | 94 | 61040 | 9878 | 31626332 |
Infusion site extravasation | 73.68 | 10.53 | 59 | 61075 | 3578 | 31632632 |
Arteriospasm coronary | 71.94 | 10.53 | 53 | 61081 | 2838 | 31633372 |
Vasoplegia syndrome | 70.66 | 10.53 | 43 | 61091 | 1670 | 31634540 |
Tachycardia | 69.30 | 10.53 | 311 | 60823 | 75896 | 31560314 |
Expired product administered | 69.24 | 10.53 | 53 | 61081 | 3008 | 31633202 |
Upper respiratory tract infection | 69.03 | 10.53 | 166 | 60968 | 29256 | 31606954 |
Injury associated with device | 68.89 | 10.53 | 34 | 61100 | 866 | 31635344 |
Device use issue | 68.18 | 10.53 | 27 | 61107 | 398 | 31635812 |
General physical health deterioration | 64.74 | 10.53 | 74 | 61060 | 113361 | 31522849 |
Incorrect route of product administration | 62.90 | 10.53 | 94 | 61040 | 11579 | 31624631 |
Pain | 58.83 | 10.53 | 584 | 60550 | 186175 | 31450035 |
Hypoxic-ischaemic encephalopathy | 56.92 | 10.53 | 55 | 61079 | 4286 | 31631924 |
Cardiogenic shock | 56.45 | 10.53 | 130 | 61004 | 22278 | 31613932 |
Completed suicide | 56.33 | 10.53 | 56 | 61078 | 91458 | 31544752 |
Stress | 55.61 | 10.53 | 138 | 60996 | 24803 | 31611407 |
Angioedema | 54.98 | 10.53 | 166 | 60968 | 33452 | 31602758 |
Infusion site erythema | 54.86 | 10.53 | 38 | 61096 | 1845 | 31634365 |
Injection site injury | 51.66 | 10.53 | 19 | 61115 | 226 | 31635984 |
Unresponsive to stimuli | 51.57 | 10.53 | 137 | 60997 | 25663 | 31610547 |
COVID-19 | 51.53 | 10.53 | 226 | 60908 | 54595 | 31581615 |
Kounis syndrome | 51.39 | 10.53 | 38 | 61096 | 2046 | 31634164 |
Pulse absent | 50.52 | 10.53 | 57 | 61077 | 5320 | 31630890 |
Sinus tachycardia | 50.32 | 10.53 | 101 | 61033 | 15748 | 31620462 |
Interstitial lung disease | 47.30 | 10.53 | 30 | 61104 | 61373 | 31574837 |
Electrocardiogram QRS complex prolonged | 47.03 | 10.53 | 49 | 61085 | 4180 | 31632030 |
Rheumatoid arthritis | 46.51 | 10.53 | 17 | 61117 | 47792 | 31588418 |
Anaemia | 46.38 | 10.53 | 233 | 60901 | 213289 | 31422921 |
Decreased appetite | 44.66 | 10.53 | 149 | 60985 | 153068 | 31483142 |
Metabolic acidosis | 44.14 | 10.53 | 172 | 60962 | 39405 | 31596805 |
Infusion site pruritus | 43.88 | 10.53 | 22 | 61112 | 580 | 31635630 |
Psoriasis | 43.16 | 10.53 | 18 | 61116 | 46701 | 31589509 |
Endophthalmitis | 42.20 | 10.53 | 43 | 61091 | 3573 | 31632637 |
Haemodynamic instability | 40.52 | 10.53 | 65 | 61069 | 8510 | 31627700 |
Accidental overdose | 40.34 | 10.53 | 101 | 61033 | 18249 | 31617961 |
Disease progression | 39.73 | 10.53 | 71 | 61063 | 90393 | 31545817 |
Multiple organ dysfunction syndrome | 39.65 | 10.53 | 246 | 60888 | 67957 | 31568253 |
Wrong product administered | 38.94 | 10.53 | 48 | 61086 | 4920 | 31631290 |
Corneal reflex decreased | 38.89 | 10.53 | 14 | 61120 | 156 | 31636054 |
Injection site coldness | 38.48 | 10.53 | 9 | 61125 | 15 | 31636195 |
Generalised tonic-clonic seizure | 37.99 | 10.53 | 104 | 61030 | 19827 | 31616383 |
Drug intolerance | 37.95 | 10.53 | 27 | 61107 | 52006 | 31584204 |
Hyperthermia malignant | 37.69 | 10.53 | 31 | 61103 | 1953 | 31634257 |
Post procedural complication | 36.59 | 10.53 | 70 | 61064 | 10536 | 31625674 |
Anaesthetic complication neurological | 36.46 | 10.53 | 16 | 61118 | 309 | 31635901 |
Overdose | 36.04 | 10.53 | 283 | 60851 | 84381 | 31551829 |
Anxiety | 35.88 | 10.53 | 299 | 60835 | 90734 | 31545476 |
Infusion site rash | 35.75 | 10.53 | 17 | 61117 | 398 | 31635812 |
Urticaria | 35.68 | 10.53 | 211 | 60923 | 57306 | 31578904 |
Mydriasis | 35.64 | 10.53 | 53 | 61081 | 6499 | 31629711 |
Ventricular extrasystoles | 35.36 | 10.53 | 71 | 61063 | 11071 | 31625139 |
Cardiotoxicity | 35.33 | 10.53 | 46 | 61088 | 4981 | 31631229 |
Administration site pain | 35.01 | 10.53 | 14 | 61120 | 212 | 31635998 |
Liquid product physical issue | 33.83 | 10.53 | 16 | 61118 | 370 | 31635840 |
Acute kidney injury | 33.72 | 10.53 | 361 | 60773 | 279353 | 31356857 |
Infusion related reaction | 33.57 | 10.53 | 182 | 60952 | 47873 | 31588337 |
Weight decreased | 33.30 | 10.53 | 177 | 60957 | 159775 | 31476435 |
Pulseless electrical activity | 33.18 | 10.53 | 52 | 61082 | 6675 | 31629535 |
Infusion site nodule | 33.15 | 10.53 | 11 | 61123 | 94 | 31636116 |
Hypoxia | 32.78 | 10.53 | 187 | 60947 | 50126 | 31586084 |
Respiratory depression | 32.04 | 10.53 | 80 | 61054 | 14430 | 31621780 |
Asthenia | 31.74 | 10.53 | 279 | 60855 | 224476 | 31411734 |
Delayed recovery from anaesthesia | 31.69 | 10.53 | 19 | 61115 | 718 | 31635492 |
Incorrect drug administration rate | 31.60 | 10.53 | 24 | 61110 | 1346 | 31634864 |
Leukopenia | 31.60 | 10.53 | 39 | 61095 | 57789 | 31578421 |
Procedural haemorrhage | 31.52 | 10.53 | 30 | 61104 | 2294 | 31633916 |
Medical device site laceration | 31.52 | 10.53 | 6 | 61128 | 0 | 31636210 |
Infusion site bruising | 31.37 | 10.53 | 17 | 61117 | 528 | 31635682 |
Hyperdynamic left ventricle | 31.19 | 10.53 | 12 | 61122 | 163 | 31636047 |
Neutropenia | 30.52 | 10.53 | 153 | 60981 | 140211 | 31495999 |
BRASH syndrome | 30.24 | 10.53 | 14 | 61120 | 308 | 31635902 |
Apnoea | 30.21 | 10.53 | 48 | 61086 | 6234 | 31629976 |
Death | 30.12 | 10.53 | 502 | 60632 | 360067 | 31276143 |
Laryngeal oedema | 30.05 | 10.53 | 34 | 61100 | 3183 | 31633027 |
Brain oedema | 29.66 | 10.53 | 72 | 61062 | 12760 | 31623450 |
Removal of foreign body | 29.45 | 10.53 | 7 | 61127 | 13 | 31636197 |
Eyelid rash | 29.41 | 10.53 | 8 | 61126 | 31 | 31636179 |
Corneal oedema | 29.20 | 10.53 | 22 | 61112 | 1219 | 31634991 |
Mean arterial pressure decreased | 29.10 | 10.53 | 11 | 61123 | 142 | 31636068 |
Infusion site haemorrhage | 28.93 | 10.53 | 19 | 61115 | 844 | 31635366 |
Blood pressure decreased | 28.91 | 10.53 | 175 | 60959 | 47916 | 31588294 |
Oculocardiac reflex | 28.81 | 10.53 | 9 | 61125 | 62 | 31636148 |
Malignant neoplasm progression | 28.76 | 10.53 | 69 | 61065 | 78929 | 31557281 |
Retinal artery occlusion | 28.74 | 10.53 | 25 | 61109 | 1701 | 31634509 |
Injection site pain | 28.25 | 10.53 | 137 | 60997 | 34497 | 31601713 |
Spinal cord infarction | 28.08 | 10.53 | 13 | 61121 | 286 | 31635924 |
Respiratory tract infection | 28.03 | 10.53 | 86 | 61048 | 17475 | 31618735 |
Cauda equina syndrome | 27.91 | 10.53 | 15 | 61119 | 458 | 31635752 |
Toxicity to various agents | 27.80 | 10.53 | 498 | 60636 | 180989 | 31455221 |
Injection site hypoaesthesia | 27.32 | 10.53 | 9 | 61125 | 75 | 31636135 |
Factor V Leiden mutation | 27.21 | 10.53 | 9 | 61125 | 76 | 31636134 |
Hypersensitivity | 26.91 | 10.53 | 192 | 60942 | 55551 | 31580659 |
Pancytopenia | 26.74 | 10.53 | 83 | 61051 | 87233 | 31548977 |
Electrocardiogram ST segment depression | 26.67 | 10.53 | 27 | 61107 | 2226 | 31633984 |
Oedema peripheral | 26.67 | 10.53 | 115 | 61019 | 109724 | 31526486 |
Cyanosis | 26.22 | 10.53 | 65 | 61069 | 11670 | 31624540 |
Eye infection | 25.96 | 10.53 | 31 | 61103 | 3074 | 31633136 |
Hypopyon | 25.51 | 10.53 | 13 | 61121 | 355 | 31635855 |
Thrombocytopenia | 25.43 | 10.53 | 166 | 60968 | 142581 | 31493629 |
Cardiac failure congestive | 25.36 | 10.53 | 74 | 61060 | 79313 | 31556897 |
Melaena | 25.07 | 10.53 | 16 | 61118 | 32638 | 31603572 |
Haemoglobin decreased | 24.96 | 10.53 | 122 | 61012 | 112553 | 31523657 |
White blood cell count decreased | 24.74 | 10.53 | 86 | 61048 | 87312 | 31548898 |
Myocardial stunning | 24.63 | 10.53 | 6 | 61128 | 13 | 31636197 |
Diabetes mellitus | 23.99 | 10.53 | 28 | 61106 | 42528 | 31593682 |
Trigemino-cardiac reflex | 23.79 | 10.53 | 10 | 61124 | 173 | 31636037 |
Device malfunction | 23.60 | 10.53 | 54 | 61080 | 9212 | 31626998 |
Administration site swelling | 23.59 | 10.53 | 10 | 61124 | 177 | 31636033 |
Systolic anterior motion of mitral valve | 23.52 | 10.53 | 7 | 61127 | 40 | 31636170 |
Hyponatraemia | 23.42 | 10.53 | 69 | 61065 | 73730 | 31562480 |
Aqueous fibrin | 23.23 | 10.53 | 7 | 61127 | 42 | 31636168 |
Multiple allergies | 23.19 | 10.53 | 26 | 61108 | 2409 | 31633801 |
Pulmonary oedema | 23.08 | 10.53 | 156 | 60978 | 44346 | 31591864 |
Circulatory collapse | 22.98 | 10.53 | 87 | 61047 | 19657 | 31616553 |
Respiratory acidosis | 22.94 | 10.53 | 36 | 61098 | 4626 | 31631584 |
Dehydration | 22.50 | 10.53 | 136 | 60998 | 118975 | 31517235 |
Anal sphincter atony | 22.48 | 10.53 | 8 | 61126 | 86 | 31636124 |
Loss of consciousness | 22.41 | 10.53 | 238 | 60896 | 77117 | 31559093 |
Tryptase increased | 22.29 | 10.53 | 10 | 61124 | 204 | 31636006 |
Coronary artery disease | 22.24 | 10.53 | 34 | 61100 | 46053 | 31590157 |
Nasopharyngitis | 21.92 | 10.53 | 202 | 60932 | 63043 | 31573167 |
Agranulocytosis | 21.62 | 10.53 | 7 | 61127 | 21240 | 31614970 |
Respiratory arrest | 21.51 | 10.53 | 104 | 61030 | 26153 | 31610057 |
Embolia cutis medicamentosa | 21.39 | 10.53 | 10 | 61124 | 225 | 31635985 |
Croup infectious | 21.30 | 10.53 | 11 | 61123 | 309 | 31635901 |
Injection site discolouration | 21.26 | 10.53 | 19 | 61115 | 1340 | 31634870 |
Procedural hypotension | 21.24 | 10.53 | 16 | 61118 | 886 | 31635324 |
Tubulointerstitial nephritis | 20.86 | 10.53 | 5 | 61129 | 18491 | 31617719 |
Infusion site mass | 20.71 | 10.53 | 11 | 61123 | 328 | 31635882 |
Hypoglycaemia | 20.59 | 10.53 | 42 | 61092 | 50904 | 31585306 |
Swollen tongue | 20.54 | 10.53 | 63 | 61071 | 12799 | 31623411 |
Dermatitis atopic | 20.48 | 10.53 | 35 | 61099 | 4827 | 31631383 |
Procedural complication | 20.48 | 10.53 | 32 | 61102 | 4097 | 31632113 |
Neuromuscular block prolonged | 20.07 | 10.53 | 12 | 61122 | 451 | 31635759 |
Administration site erythema | 19.94 | 10.53 | 7 | 61127 | 72 | 31636138 |
Skin texture abnormal | 19.91 | 10.53 | 6 | 61128 | 36 | 31636174 |
Chondromalacia | 19.89 | 10.53 | 5 | 61129 | 13 | 31636197 |
Prostate cancer | 19.87 | 10.53 | 26 | 61108 | 37575 | 31598635 |
Coagulation factor deficiency | 19.78 | 10.53 | 8 | 61126 | 125 | 31636085 |
Atrioventricular block complete | 19.73 | 10.53 | 48 | 61086 | 8517 | 31627693 |
Haematochezia | 19.38 | 10.53 | 30 | 61104 | 40434 | 31595776 |
Pupil fixed | 19.38 | 10.53 | 20 | 61114 | 1687 | 31634523 |
Dyspnoea exertional | 19.37 | 10.53 | 28 | 61106 | 38809 | 31597401 |
Macroglossia | 19.29 | 10.53 | 11 | 61123 | 378 | 31635832 |
Bronchopulmonary aspergillosis allergic | 19.14 | 10.53 | 13 | 61121 | 611 | 31635599 |
Left ventricle outflow tract obstruction | 18.90 | 10.53 | 8 | 61126 | 141 | 31636069 |
Familial periodic paralysis | 18.83 | 10.53 | 7 | 61127 | 86 | 31636124 |
Hepatocellular injury | 18.79 | 10.53 | 9 | 61125 | 21535 | 31614675 |
Intracranial hypotension | 18.61 | 10.53 | 9 | 61125 | 219 | 31635991 |
Injection site extravasation | 18.52 | 10.53 | 24 | 61110 | 2586 | 31633624 |
Malaise | 18.47 | 10.53 | 222 | 60912 | 168289 | 31467921 |
Headache | 18.41 | 10.53 | 474 | 60660 | 183178 | 31453032 |
Platelet count decreased | 18.37 | 10.53 | 131 | 61003 | 110304 | 31525906 |
Eyelid oedema | 18.11 | 10.53 | 33 | 61101 | 4787 | 31631423 |
Pancreatitis acute | 17.74 | 10.53 | 14 | 61120 | 25586 | 31610624 |
Blood pressure fluctuation | 17.65 | 10.53 | 11 | 61123 | 22725 | 31613485 |
Phaeochromocytoma crisis | 17.61 | 10.53 | 6 | 61128 | 56 | 31636154 |
Anterior chamber cell | 17.61 | 10.53 | 10 | 61124 | 341 | 31635869 |
Suicide attempt | 17.47 | 10.53 | 28 | 61106 | 37220 | 31598990 |
Abdominal pain | 17.27 | 10.53 | 189 | 60945 | 145763 | 31490447 |
Angina pectoris | 17.25 | 10.53 | 19 | 61115 | 29622 | 31606588 |
Oxygen saturation decreased | 17.08 | 10.53 | 157 | 60977 | 48958 | 31587252 |
Ophthalmoplegia | 17.05 | 10.53 | 19 | 61115 | 1749 | 31634461 |
Cardiac arrest neonatal | 17.04 | 10.53 | 5 | 61129 | 27 | 31636183 |
Jaundice | 16.99 | 10.53 | 20 | 61114 | 30267 | 31605943 |
Reperfusion arrhythmia | 16.99 | 10.53 | 6 | 61128 | 63 | 31636147 |
International normalised ratio increased | 16.85 | 10.53 | 39 | 61095 | 45184 | 31591026 |
Gastrointestinal haemorrhage | 16.79 | 10.53 | 92 | 61042 | 82457 | 31553753 |
Food allergy | 16.76 | 10.53 | 15 | 61119 | 1060 | 31635150 |
Vitritis | 16.70 | 10.53 | 13 | 61121 | 756 | 31635454 |
Respiratory distress | 16.44 | 10.53 | 116 | 61018 | 33437 | 31602773 |
Plasma cell myeloma | 16.42 | 10.53 | 55 | 61079 | 56476 | 31579734 |
Myalgia | 16.33 | 10.53 | 85 | 61049 | 77173 | 31559037 |
Illness | 16.29 | 10.53 | 47 | 61087 | 9230 | 31626980 |
Asthma | 16.26 | 10.53 | 139 | 60995 | 42472 | 31593738 |
Intentional self-injury | 16.24 | 10.53 | 3 | 61131 | 13312 | 31622898 |
Dry gangrene | 16.23 | 10.53 | 10 | 61124 | 397 | 31635813 |
Seizure like phenomena | 16.16 | 10.53 | 12 | 61122 | 650 | 31635560 |
Coma | 16.11 | 10.53 | 135 | 60999 | 41015 | 31595195 |
Pulmonary fibrosis | 16.07 | 10.53 | 6 | 61128 | 16654 | 31619556 |
Catecholamine crisis | 16.06 | 10.53 | 5 | 61129 | 34 | 31636176 |
Administration site irritation | 16.02 | 10.53 | 4 | 61130 | 10 | 31636200 |
Sinus arrest | 15.99 | 10.53 | 17 | 61117 | 1484 | 31634726 |
Blood lactic acid increased | 15.91 | 10.53 | 36 | 61098 | 6094 | 31630116 |
Cholestasis | 15.81 | 10.53 | 15 | 61119 | 25060 | 31611150 |
Product adhesion issue | 15.77 | 10.53 | 17 | 61117 | 1508 | 31634702 |
Administration site scar | 15.76 | 10.53 | 3 | 61131 | 0 | 31636210 |
Deep vein thrombosis | 15.72 | 10.53 | 62 | 61072 | 60674 | 31575536 |
Areflexia | 15.63 | 10.53 | 23 | 61111 | 2793 | 31633417 |
Paralysis | 15.54 | 10.53 | 34 | 61100 | 5629 | 31630581 |
Vitreous floaters | 15.53 | 10.53 | 25 | 61109 | 3282 | 31632928 |
COVID-19 immunisation | 15.48 | 10.53 | 8 | 61126 | 225 | 31635985 |
Cytomegalovirus infection | 15.32 | 10.53 | 15 | 61119 | 24692 | 31611518 |
Brain stem syndrome | 15.23 | 10.53 | 10 | 61124 | 444 | 31635766 |
Hepatotoxicity | 15.20 | 10.53 | 9 | 61125 | 19117 | 31617093 |
Musculoskeletal stiffness | 15.11 | 10.53 | 36 | 61098 | 41289 | 31594921 |
Injury corneal | 15.02 | 10.53 | 4 | 61130 | 14 | 31636196 |
Anion gap | 15.02 | 10.53 | 12 | 61122 | 725 | 31635485 |
Vitreous disorder | 14.94 | 10.53 | 6 | 61128 | 92 | 31636118 |
Neuromuscular blockade | 14.89 | 10.53 | 8 | 61126 | 244 | 31635966 |
Drug-induced liver injury | 14.87 | 10.53 | 15 | 61119 | 24348 | 31611862 |
Paraplegia | 14.87 | 10.53 | 22 | 61112 | 2685 | 31633525 |
Insurance issue | 14.83 | 10.53 | 15 | 61119 | 1235 | 31634975 |
Bladder cancer | 14.72 | 10.53 | 5 | 61129 | 14720 | 31621490 |
Paraesthesia oral | 14.71 | 10.53 | 26 | 61108 | 3682 | 31632528 |
Throat tightness | 14.59 | 10.53 | 40 | 61094 | 7629 | 31628581 |
Respiratory tract infection bacterial | 14.56 | 10.53 | 16 | 61118 | 1450 | 31634760 |
Electrocardiogram T wave amplitude increased | 14.55 | 10.53 | 5 | 61129 | 48 | 31636162 |
Fatigue | 14.53 | 10.53 | 515 | 60619 | 334691 | 31301519 |
Transient ischaemic attack | 14.47 | 10.53 | 15 | 61119 | 24041 | 31612169 |
Allergy to arthropod sting | 14.46 | 10.53 | 5 | 61129 | 49 | 31636161 |
Recalled product administered | 14.43 | 10.53 | 10 | 61124 | 486 | 31635724 |
Accelerated idioventricular rhythm | 14.37 | 10.53 | 6 | 61128 | 102 | 31636108 |
Pallor | 14.37 | 10.53 | 83 | 61051 | 22341 | 31613869 |
Blindness | 14.35 | 10.53 | 55 | 61079 | 12496 | 31623714 |
Skin infection | 14.28 | 10.53 | 37 | 61097 | 6826 | 31629384 |
Stridor | 14.24 | 10.53 | 20 | 61114 | 2327 | 31633883 |
Myocardial infarction | 14.19 | 10.53 | 145 | 60989 | 113309 | 31522901 |
Haematuria | 14.19 | 10.53 | 44 | 61090 | 46270 | 31589940 |
Hepatitis | 14.15 | 10.53 | 13 | 61121 | 22053 | 31614157 |
Myopathy toxic | 14.14 | 10.53 | 10 | 61124 | 502 | 31635708 |
Retinal vasculitis | 14.09 | 10.53 | 9 | 61125 | 381 | 31635829 |
Pharyngeal oedema | 13.91 | 10.53 | 33 | 61101 | 5763 | 31630447 |
Tracheitis | 13.89 | 10.53 | 11 | 61123 | 656 | 31635554 |
Administration site pruritus | 13.72 | 10.53 | 4 | 61130 | 21 | 31636189 |
End-tidal CO2 decreased | 13.69 | 10.53 | 3 | 61131 | 3 | 31636207 |
Electrocardiogram ST-T segment depression | 13.69 | 10.53 | 3 | 61131 | 3 | 31636207 |
General anaesthesia | 13.69 | 10.53 | 3 | 61131 | 3 | 31636207 |
Drug resistance | 13.68 | 10.53 | 15 | 61119 | 23438 | 31612772 |
Bronchitis | 13.58 | 10.53 | 124 | 61010 | 38593 | 31597617 |
Foreign body | 13.56 | 10.53 | 13 | 61121 | 1003 | 31635207 |
Alopecia | 13.50 | 10.53 | 12 | 61122 | 20683 | 31615527 |
Respiratory tract infection viral | 13.49 | 10.53 | 18 | 61116 | 1996 | 31634214 |
Corneal opacity | 13.48 | 10.53 | 10 | 61124 | 541 | 31635669 |
Orthostatic hypotension | 13.45 | 10.53 | 16 | 61118 | 24103 | 31612107 |
Eosinophilia | 13.43 | 10.53 | 15 | 61119 | 23238 | 31612972 |
Administration site reaction | 13.34 | 10.53 | 5 | 61129 | 63 | 31636147 |
Cardiac failure | 13.32 | 10.53 | 104 | 61030 | 85849 | 31550361 |
Gas gangrene | 13.27 | 10.53 | 5 | 61129 | 64 | 31636146 |
Injection site joint infection | 13.14 | 10.53 | 4 | 61130 | 25 | 31636185 |
Pharyngeal swelling | 13.12 | 10.53 | 17 | 61117 | 1832 | 31634378 |
Infusion site irritation | 13.05 | 10.53 | 7 | 61127 | 213 | 31635997 |
Product administered at inappropriate site | 13.04 | 10.53 | 17 | 61117 | 1843 | 31634367 |
Ventricular arrhythmia | 13.01 | 10.53 | 29 | 61105 | 4862 | 31631348 |
Coagulation factor V level abnormal | 13.00 | 10.53 | 4 | 61130 | 26 | 31636184 |
Rectal haemorrhage | 12.97 | 10.53 | 32 | 61102 | 36272 | 31599938 |
Neoplasm progression | 12.93 | 10.53 | 12 | 61122 | 20260 | 31615950 |
Pupillary reflex impaired | 12.90 | 10.53 | 15 | 61119 | 1446 | 31634764 |
Gait disturbance | 12.85 | 10.53 | 92 | 61042 | 77403 | 31558807 |
Insomnia | 12.79 | 10.53 | 119 | 61015 | 94717 | 31541493 |
Mouth swelling | 12.75 | 10.53 | 16 | 61118 | 1670 | 31634540 |
Intestinal haematoma | 12.61 | 10.53 | 5 | 61129 | 74 | 31636136 |
Seasonal allergy | 12.53 | 10.53 | 31 | 61103 | 5557 | 31630653 |
Drug interaction | 12.36 | 10.53 | 307 | 60827 | 208236 | 31427974 |
Blood creatinine increased | 12.35 | 10.53 | 111 | 61023 | 88967 | 31547243 |
Hyperaesthesia | 12.32 | 10.53 | 25 | 61109 | 3926 | 31632284 |
Compartment syndrome | 12.28 | 10.53 | 20 | 61114 | 2651 | 31633559 |
Nodal rhythm | 12.23 | 10.53 | 14 | 61120 | 1327 | 31634883 |
Gastroenteritis viral | 12.20 | 10.53 | 33 | 61101 | 6244 | 31629966 |
Administration related reaction | 12.14 | 10.53 | 5 | 61129 | 82 | 31636128 |
Gamma-glutamyltransferase increased | 12.06 | 10.53 | 22 | 61112 | 27803 | 31608407 |
Anaphylactoid shock | 12.05 | 10.53 | 8 | 61126 | 362 | 31635848 |
Polyneuropathy | 12.05 | 10.53 | 5 | 61129 | 13017 | 31623193 |
Visual acuity reduced | 12.01 | 10.53 | 60 | 61074 | 15283 | 31620927 |
Non-infectious endophthalmitis | 12.01 | 10.53 | 6 | 61128 | 157 | 31636053 |
Wheezing | 11.99 | 10.53 | 114 | 61020 | 35872 | 31600338 |
Myelosuppression | 11.88 | 10.53 | 7 | 61127 | 14913 | 31621297 |
Laryngeal stenosis | 11.87 | 10.53 | 5 | 61129 | 87 | 31636123 |
Myokymia | 11.87 | 10.53 | 5 | 61129 | 87 | 31636123 |
Constipation | 11.86 | 10.53 | 168 | 60966 | 123823 | 31512387 |
Infusion site reaction | 11.80 | 10.53 | 11 | 61123 | 819 | 31635391 |
Optic nerve injury | 11.77 | 10.53 | 5 | 61129 | 89 | 31636121 |
Quadriplegia | 11.72 | 10.53 | 15 | 61119 | 1596 | 31634614 |
Alanine aminotransferase increased | 11.72 | 10.53 | 90 | 61044 | 74566 | 31561644 |
Heart rate increased | 11.67 | 10.53 | 126 | 61008 | 40984 | 31595226 |
Mobility decreased | 11.65 | 10.53 | 22 | 61112 | 27447 | 31608763 |
Burkholderia test positive | 11.65 | 10.53 | 12 | 61122 | 1010 | 31635200 |
Infusion site vesicles | 11.57 | 10.53 | 6 | 61128 | 170 | 31636040 |
Liver function test abnormal | 11.55 | 10.53 | 25 | 61109 | 29667 | 31606543 |
Apgar score low | 11.43 | 10.53 | 11 | 61123 | 853 | 31635357 |
Pneumocystis jirovecii pneumonia | 11.41 | 10.53 | 11 | 61123 | 18240 | 31617970 |
Eye inflammation | 11.36 | 10.53 | 16 | 61118 | 1867 | 31634343 |
Torsade de pointes | 11.35 | 10.53 | 34 | 61100 | 6816 | 31629394 |
Seizure | 11.33 | 10.53 | 262 | 60872 | 99506 | 31536704 |
Product dose omission issue | 11.30 | 10.53 | 275 | 60859 | 105311 | 31530899 |
Device issue | 11.24 | 10.53 | 39 | 61095 | 8445 | 31627765 |
Oral lichen planus | 11.23 | 10.53 | 6 | 61128 | 181 | 31636029 |
Nephropathy toxic | 11.10 | 10.53 | 4 | 61130 | 11349 | 31624861 |
Drug reaction with eosinophilia and systemic symptoms | 11.09 | 10.53 | 26 | 61108 | 29992 | 31606218 |
Hallucination | 11.00 | 10.53 | 49 | 61085 | 46361 | 31589849 |
Retinal vascular occlusion | 10.99 | 10.53 | 6 | 61128 | 189 | 31636021 |
Status asthmaticus | 10.95 | 10.53 | 7 | 61127 | 297 | 31635913 |
Spinal cord oedema | 10.88 | 10.53 | 6 | 61128 | 193 | 31636017 |
Disease recurrence | 10.82 | 10.53 | 12 | 61122 | 18649 | 31617561 |
Penile vascular disorder | 10.76 | 10.53 | 3 | 61131 | 13 | 31636197 |
Liver disorder | 10.76 | 10.53 | 26 | 61108 | 29681 | 31606529 |
Product distribution issue | 10.69 | 10.53 | 8 | 61126 | 439 | 31635771 |
Posterior capsule rupture | 10.58 | 10.53 | 3 | 61131 | 14 | 31636196 |
Multiple sclerosis relapse | 10.56 | 10.53 | 5 | 61129 | 12042 | 31624168 |
Bone marrow failure | 10.56 | 10.53 | 24 | 61110 | 27984 | 31608226 |
Pharyngitis streptococcal | 10.54 | 10.53 | 17 | 61117 | 2236 | 31633974 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic reaction | 876.08 | 9.55 | 891 | 135858 | 74083 | 70717612 |
Cardiac arrest | 601.23 | 9.55 | 1093 | 135656 | 158741 | 70632954 |
Local anaesthetic systemic toxicity | 562.84 | 9.55 | 158 | 136591 | 707 | 70790988 |
Stress cardiomyopathy | 552.42 | 9.55 | 302 | 136447 | 9560 | 70782135 |
Toxic anterior segment syndrome | 521.86 | 9.55 | 195 | 136554 | 2435 | 70789260 |
Anaesthetic complication | 496.02 | 9.55 | 188 | 136561 | 2448 | 70789247 |
Anaphylactic shock | 476.98 | 9.55 | 438 | 136311 | 32052 | 70759643 |
Hereditary angioedema | 363.39 | 9.55 | 183 | 136566 | 4876 | 70786819 |
Device failure | 347.17 | 9.55 | 186 | 136563 | 5649 | 70786046 |
Chondrolysis | 330.88 | 9.55 | 86 | 136663 | 267 | 70791428 |
Ventricular tachycardia | 297.29 | 9.55 | 359 | 136390 | 36064 | 70755631 |
Hypotension | 289.37 | 9.55 | 1539 | 135210 | 402842 | 70388853 |
Rheumatoid arthritis | 262.59 | 9.55 | 117 | 136632 | 291688 | 70500007 |
Drug ineffective | 245.43 | 9.55 | 2825 | 133924 | 936927 | 69854768 |
Fear | 225.98 | 9.55 | 238 | 136511 | 20573 | 70771122 |
Sinusitis | 224.32 | 9.55 | 777 | 135972 | 168418 | 70623277 |
Lagophthalmos | 211.99 | 9.55 | 63 | 136686 | 358 | 70791337 |
Bradycardia | 211.41 | 9.55 | 623 | 136126 | 123992 | 70667703 |
Renal injury | 203.81 | 9.55 | 200 | 136549 | 15894 | 70775801 |
Drug intolerance | 189.97 | 9.55 | 99 | 136650 | 225588 | 70566107 |
Completed suicide | 187.71 | 9.55 | 102 | 136647 | 227033 | 70564662 |
Shock | 183.83 | 9.55 | 301 | 136448 | 40124 | 70751571 |
Pulseless electrical activity | 178.21 | 9.55 | 170 | 136579 | 13045 | 70778650 |
Bronchospasm | 176.81 | 9.55 | 219 | 136530 | 22573 | 70769122 |
Ventricular fibrillation | 175.17 | 9.55 | 238 | 136511 | 26873 | 70764822 |
Incorrect route of product administration | 171.83 | 9.55 | 233 | 136516 | 26259 | 70765436 |
Anhedonia | 171.42 | 9.55 | 172 | 136577 | 14041 | 70777654 |
Kounis syndrome | 170.66 | 9.55 | 97 | 136652 | 3314 | 70788381 |
Methaemoglobinaemia | 159.60 | 9.55 | 105 | 136644 | 4681 | 70787014 |
Joint swelling | 156.92 | 9.55 | 154 | 136595 | 253057 | 70538638 |
Contraindicated product administered | 156.61 | 9.55 | 34 | 136715 | 134578 | 70657117 |
Synovitis | 155.82 | 9.55 | 30 | 136719 | 129198 | 70662497 |
Unevaluable event | 149.24 | 9.55 | 318 | 136431 | 51745 | 70739950 |
Accidental exposure to product | 148.52 | 9.55 | 224 | 136525 | 27827 | 70763868 |
General physical health deterioration | 146.89 | 9.55 | 143 | 136606 | 235888 | 70555807 |
Cardiogenic shock | 143.49 | 9.55 | 254 | 136495 | 36053 | 70755642 |
Emotional distress | 142.91 | 9.55 | 257 | 136492 | 36931 | 70754764 |
Hand deformity | 140.88 | 9.55 | 6 | 136743 | 86476 | 70705219 |
Product quality issue | 139.54 | 9.55 | 228 | 136521 | 30333 | 70761362 |
Angioedema | 137.64 | 9.55 | 358 | 136391 | 66252 | 70725443 |
Injury | 136.19 | 9.55 | 352 | 136397 | 64893 | 70726802 |
Pemphigus | 134.48 | 9.55 | 6 | 136743 | 83030 | 70708665 |
Tachycardia | 130.95 | 9.55 | 629 | 136120 | 157917 | 70633778 |
Electrocardiogram ST segment elevation | 130.43 | 9.55 | 112 | 136637 | 7492 | 70784203 |
Arteriospasm coronary | 129.10 | 9.55 | 101 | 136648 | 5923 | 70785772 |
Hepatic enzyme increased | 126.05 | 9.55 | 73 | 136676 | 156917 | 70634778 |
Corneal oedema | 125.89 | 9.55 | 71 | 136678 | 2389 | 70789306 |
Urticaria | 117.85 | 9.55 | 623 | 136126 | 162426 | 70629269 |
Vasoplegia syndrome | 114.48 | 9.55 | 73 | 136676 | 3083 | 70788612 |
Diarrhoea | 112.78 | 9.55 | 968 | 135781 | 782373 | 70009322 |
Pericarditis | 107.93 | 9.55 | 17 | 136732 | 84688 | 70707007 |
Infusion site swelling | 107.75 | 9.55 | 92 | 136657 | 6106 | 70785589 |
Injection site pallor | 106.04 | 9.55 | 25 | 136724 | 44 | 70791651 |
Pulse absent | 103.60 | 9.55 | 108 | 136641 | 9222 | 70782473 |
Glossodynia | 102.31 | 9.55 | 21 | 136728 | 86466 | 70705229 |
Endophthalmitis | 100.97 | 9.55 | 89 | 136660 | 6166 | 70785529 |
Left ventricle outflow tract obstruction | 100.72 | 9.55 | 34 | 136715 | 308 | 70791387 |
Systemic lupus erythematosus | 99.47 | 9.55 | 36 | 136713 | 101866 | 70689829 |
Maternal exposure during delivery | 98.44 | 9.55 | 45 | 136704 | 961 | 70790734 |
Infusion site extravasation | 96.73 | 9.55 | 97 | 136652 | 7911 | 70783784 |
Drug ineffective for unapproved indication | 96.47 | 9.55 | 223 | 136526 | 38315 | 70753380 |
COVID-19 | 96.44 | 9.55 | 432 | 136317 | 105325 | 70686370 |
Unresponsive to stimuli | 96.10 | 9.55 | 268 | 136481 | 51663 | 70740032 |
Haemodynamic instability | 95.94 | 9.55 | 134 | 136615 | 15524 | 70776171 |
Generalised tonic-clonic seizure | 95.55 | 9.55 | 233 | 136516 | 41428 | 70750267 |
Cauda equina syndrome | 95.32 | 9.55 | 47 | 136702 | 1195 | 70790500 |
Sinus tachycardia | 94.72 | 9.55 | 205 | 136544 | 33708 | 70757987 |
Infusion site erythema | 94.21 | 9.55 | 93 | 136656 | 7442 | 70784253 |
Arthropathy | 90.90 | 9.55 | 93 | 136656 | 149964 | 70641731 |
Stridor | 89.58 | 9.55 | 76 | 136673 | 5000 | 70786695 |
Arthralgia | 87.41 | 9.55 | 590 | 136159 | 502800 | 70288895 |
Injury associated with device | 85.93 | 9.55 | 60 | 136689 | 2952 | 70788743 |
Infusion site pain | 84.72 | 9.55 | 108 | 136641 | 11456 | 70780239 |
Alopecia | 82.47 | 9.55 | 161 | 136588 | 198329 | 70593366 |
Needle issue | 81.64 | 9.55 | 103 | 136646 | 10812 | 70780883 |
Helicobacter infection | 81.23 | 9.55 | 7 | 136742 | 55649 | 70736046 |
Infusion site pruritus | 79.79 | 9.55 | 59 | 136690 | 3178 | 70788517 |
Abdominal discomfort | 79.29 | 9.55 | 186 | 136563 | 214472 | 70577223 |
Injection site ischaemia | 78.26 | 9.55 | 16 | 136733 | 7 | 70791688 |
Pulmonary oedema | 77.19 | 9.55 | 339 | 136410 | 81939 | 70709756 |
Hypopyon | 76.85 | 9.55 | 39 | 136710 | 1056 | 70790639 |
Anaesthetic complication neurological | 76.72 | 9.55 | 32 | 136717 | 543 | 70791152 |
Wrong product administered | 75.89 | 9.55 | 87 | 136662 | 8264 | 70783431 |
Therapeutic product effect decreased | 74.42 | 9.55 | 100 | 136649 | 142918 | 70648777 |
Expired product administered | 74.39 | 9.55 | 76 | 136673 | 6337 | 70785358 |
Accidental exposure to product by child | 73.37 | 9.55 | 53 | 136696 | 2753 | 70788942 |
Upper respiratory tract infection | 73.14 | 9.55 | 325 | 136424 | 78949 | 70712746 |
Electrocardiogram ST segment depression | 72.69 | 9.55 | 64 | 136685 | 4427 | 70787268 |
Ear infection | 69.86 | 9.55 | 163 | 136586 | 28173 | 70763522 |
Decreased appetite | 69.79 | 9.55 | 326 | 136423 | 304454 | 70487241 |
Post procedural complication | 69.27 | 9.55 | 140 | 136609 | 21941 | 70769754 |
Stress | 69.13 | 9.55 | 287 | 136462 | 67679 | 70724016 |
Injection site laceration | 67.69 | 9.55 | 20 | 136729 | 111 | 70791584 |
Procedural hypotension | 67.67 | 9.55 | 44 | 136705 | 1922 | 70789773 |
Wound | 67.14 | 9.55 | 55 | 136694 | 98677 | 70693018 |
Circulatory collapse | 66.54 | 9.55 | 184 | 136565 | 35290 | 70756405 |
Musculoskeletal stiffness | 65.67 | 9.55 | 115 | 136634 | 147645 | 70644050 |
Impaired quality of life | 64.89 | 9.55 | 83 | 136666 | 8833 | 70782862 |
Acute kidney injury | 64.77 | 9.55 | 594 | 136155 | 474030 | 70317665 |
Neutropenia | 63.74 | 9.55 | 267 | 136482 | 256889 | 70534806 |
Anxiety | 63.56 | 9.55 | 677 | 136072 | 219653 | 70572042 |
Blood pressure decreased | 62.89 | 9.55 | 345 | 136404 | 91170 | 70700525 |
Hyponatraemia | 62.12 | 9.55 | 135 | 136614 | 159952 | 70631743 |
Anaemia | 61.69 | 9.55 | 490 | 136259 | 402933 | 70388762 |
Injection site injury | 61.35 | 9.55 | 29 | 136720 | 670 | 70791025 |
Accidental overdose | 60.83 | 9.55 | 177 | 136572 | 34944 | 70756751 |
Psoriasis | 60.75 | 9.55 | 60 | 136689 | 98373 | 70693322 |
Metabolic acidosis | 59.91 | 9.55 | 293 | 136456 | 74053 | 70717642 |
Tryptase increased | 59.61 | 9.55 | 27 | 136722 | 564 | 70791131 |
Lower respiratory tract infection | 59.50 | 9.55 | 77 | 136672 | 111836 | 70679859 |
Airway peak pressure increased | 59.10 | 9.55 | 23 | 136726 | 323 | 70791372 |
Asthenia | 58.93 | 9.55 | 581 | 136168 | 457085 | 70334610 |
Mydriasis | 57.47 | 9.55 | 108 | 136641 | 16045 | 70775650 |
Retinal artery occlusion | 57.18 | 9.55 | 47 | 136702 | 2959 | 70788736 |
Bronchitis | 56.76 | 9.55 | 404 | 136345 | 116839 | 70674856 |
Cyanosis | 56.67 | 9.55 | 133 | 136616 | 23073 | 70768622 |
Hypoxic-ischaemic encephalopathy | 56.32 | 9.55 | 70 | 136679 | 7238 | 70784457 |
Eyelid rash | 56.14 | 9.55 | 17 | 136732 | 104 | 70791591 |
Infusion site bruising | 55.62 | 9.55 | 39 | 136710 | 1932 | 70789763 |
Multiple organ dysfunction syndrome | 55.51 | 9.55 | 379 | 136370 | 108136 | 70683559 |
Folliculitis | 55.47 | 9.55 | 8 | 136741 | 42562 | 70749133 |
Overdose | 55.37 | 9.55 | 535 | 136214 | 169210 | 70622485 |
Incorrect drug administration rate | 55.23 | 9.55 | 47 | 136702 | 3105 | 70788590 |
Swollen tongue | 55.10 | 9.55 | 177 | 136572 | 36869 | 70754826 |
Removal of foreign body | 54.40 | 9.55 | 13 | 136736 | 25 | 70791670 |
Electrocardiogram QRS complex prolonged | 54.32 | 9.55 | 80 | 136669 | 9726 | 70781969 |
Disease progression | 53.73 | 9.55 | 141 | 136608 | 156531 | 70635164 |
Peripheral ischaemia | 53.73 | 9.55 | 75 | 136674 | 8683 | 70783012 |
Sleep disorder due to general medical condition, insomnia type | 53.52 | 9.55 | 4 | 136745 | 35728 | 70755967 |
Hyperaesthesia | 53.18 | 9.55 | 84 | 136665 | 10858 | 70780837 |
Extradural abscess | 53.05 | 9.55 | 32 | 136717 | 1223 | 70790472 |
Injection site coldness | 52.96 | 9.55 | 16 | 136733 | 97 | 70791598 |
Vitritis | 52.20 | 9.55 | 35 | 136714 | 1611 | 70790084 |
Infusion site mass | 51.84 | 9.55 | 31 | 136718 | 1166 | 70790529 |
Cataract operation complication | 51.77 | 9.55 | 20 | 136729 | 275 | 70791420 |
Embolia cutis medicamentosa | 51.68 | 9.55 | 24 | 136725 | 532 | 70791163 |
Psoriatic arthropathy | 50.72 | 9.55 | 31 | 136718 | 64740 | 70726955 |
Muscle injury | 50.71 | 9.55 | 7 | 136742 | 38487 | 70753208 |
Body tinea | 50.19 | 9.55 | 32 | 136717 | 1351 | 70790344 |
Ophthalmoplegia | 49.37 | 9.55 | 42 | 136707 | 2773 | 70788922 |
Seizure | 49.07 | 9.55 | 542 | 136207 | 177420 | 70614275 |
Extradural haematoma | 48.76 | 9.55 | 41 | 136708 | 2664 | 70789031 |
Anterior chamber cell | 48.71 | 9.55 | 27 | 136722 | 878 | 70790817 |
Ventricular extrasystoles | 48.42 | 9.55 | 108 | 136641 | 18118 | 70773577 |
Illness | 48.29 | 9.55 | 153 | 136596 | 31638 | 70760057 |
Interstitial lung disease | 47.85 | 9.55 | 80 | 136669 | 104605 | 70687090 |
Lip swelling | 47.32 | 9.55 | 159 | 136590 | 33895 | 70757800 |
COVID-19 immunisation | 46.90 | 9.55 | 28 | 136721 | 1050 | 70790645 |
Respiratory depression | 46.77 | 9.55 | 129 | 136620 | 24702 | 70766993 |
Asthma | 46.68 | 9.55 | 395 | 136354 | 120398 | 70671297 |
Hypoxia | 46.55 | 9.55 | 324 | 136425 | 93020 | 70698675 |
Leukopenia | 46.37 | 9.55 | 84 | 136665 | 106476 | 70685219 |
Intentional self-injury | 46.13 | 9.55 | 4 | 136745 | 31646 | 70760049 |
Respiratory acidosis | 45.97 | 9.55 | 76 | 136673 | 10205 | 70781490 |
Mobility decreased | 45.90 | 9.55 | 80 | 136669 | 102919 | 70688776 |
Status asthmaticus | 45.67 | 9.55 | 27 | 136722 | 994 | 70790701 |
Pancytopenia | 45.24 | 9.55 | 145 | 136604 | 150962 | 70640733 |
Loss of consciousness | 45.12 | 9.55 | 479 | 136270 | 155237 | 70636458 |
Malignant neoplasm progression | 44.51 | 9.55 | 106 | 136643 | 121633 | 70670062 |
Apnoea | 44.49 | 9.55 | 77 | 136672 | 10732 | 70780963 |
C-reactive protein abnormal | 44.33 | 9.55 | 10 | 136739 | 38569 | 70753126 |
Spinal cord infarction | 44.13 | 9.55 | 22 | 136727 | 573 | 70791122 |
Neuromuscular block prolonged | 43.99 | 9.55 | 26 | 136723 | 957 | 70790738 |
Mean arterial pressure decreased | 43.98 | 9.55 | 19 | 136730 | 353 | 70791342 |
Trigemino-cardiac reflex | 43.66 | 9.55 | 17 | 136732 | 239 | 70791456 |
Hypoaesthesia oral | 43.46 | 9.55 | 82 | 136667 | 12218 | 70779477 |
Cholestasis | 43.29 | 9.55 | 19 | 136730 | 47853 | 70743842 |
Pharyngeal oedema | 42.82 | 9.55 | 94 | 136655 | 15602 | 70776093 |
Procedural complication | 42.64 | 9.55 | 62 | 136687 | 7452 | 70784243 |
Device use issue | 42.53 | 9.55 | 35 | 136714 | 2207 | 70789488 |
Paralysis | 42.06 | 9.55 | 80 | 136669 | 11992 | 70779703 |
Aqueous fibrin | 41.85 | 9.55 | 14 | 136735 | 123 | 70791572 |
Systolic anterior motion of mitral valve | 41.82 | 9.55 | 12 | 136737 | 59 | 70791636 |
Infusion site haemorrhage | 41.39 | 9.55 | 38 | 136711 | 2777 | 70788918 |
Ventricular hypokinesia | 41.24 | 9.55 | 64 | 136685 | 8148 | 70783547 |
Thrombocytopenia | 41.01 | 9.55 | 281 | 136468 | 238829 | 70552866 |
Impaired healing | 40.75 | 9.55 | 50 | 136699 | 74324 | 70717371 |
Respiratory tract infection | 39.99 | 9.55 | 175 | 136574 | 42223 | 70749472 |
Laryngeal oedema | 39.88 | 9.55 | 60 | 136689 | 7435 | 70784260 |
Delayed recovery from anaesthesia | 39.78 | 9.55 | 29 | 136720 | 1528 | 70790167 |
Nerve root injury | 39.77 | 9.55 | 10 | 136739 | 26 | 70791669 |
Hyperthermia malignant | 39.27 | 9.55 | 36 | 136713 | 2625 | 70789070 |
Paraplegia | 39.19 | 9.55 | 47 | 136702 | 4683 | 70787012 |
Product adhesion issue | 38.93 | 9.55 | 35 | 136714 | 2489 | 70789206 |
Myopathy toxic | 38.67 | 9.55 | 24 | 136725 | 966 | 70790729 |
Multiple allergies | 38.30 | 9.55 | 60 | 136689 | 7700 | 70783995 |
Retinal vasculitis | 38.22 | 9.55 | 26 | 136723 | 1226 | 70790469 |
Procedural haemorrhage | 38.02 | 9.55 | 45 | 136704 | 4422 | 70787273 |
Cardiac failure congestive | 37.80 | 9.55 | 134 | 136615 | 135323 | 70656372 |
Injection site hypoaesthesia | 37.80 | 9.55 | 18 | 136731 | 423 | 70791272 |
Toxicity to various agents | 37.70 | 9.55 | 984 | 135765 | 381188 | 70410507 |
Orthostatic hypotension | 37.49 | 9.55 | 27 | 136722 | 51716 | 70739979 |
Hyperdynamic left ventricle | 37.49 | 9.55 | 17 | 136732 | 356 | 70791339 |
Drug reaction with eosinophilia and systemic symptoms | 37.38 | 9.55 | 34 | 136715 | 57979 | 70733716 |
Medical device site laceration | 36.77 | 9.55 | 7 | 136742 | 0 | 70791695 |
Throat tightness | 36.71 | 9.55 | 119 | 136630 | 24903 | 70766792 |
Anaphylactoid shock | 36.28 | 9.55 | 21 | 136728 | 743 | 70790952 |
Bladder prolapse | 35.59 | 9.55 | 25 | 136724 | 1242 | 70790453 |
Respiratory distress | 35.52 | 9.55 | 203 | 136546 | 54447 | 70737248 |
Nerve block | 35.37 | 9.55 | 19 | 136730 | 580 | 70791115 |
Fear of eating | 35.26 | 9.55 | 17 | 136732 | 411 | 70791284 |
Blood creatinine increased | 35.07 | 9.55 | 149 | 136600 | 142852 | 70648843 |
Type 2 diabetes mellitus | 34.64 | 9.55 | 21 | 136728 | 44059 | 70747636 |
Cardiotoxicity | 34.50 | 9.55 | 70 | 136679 | 11000 | 70780695 |
Infusion site urticaria | 34.36 | 9.55 | 21 | 136728 | 822 | 70790873 |
Chondromalacia | 34.31 | 9.55 | 13 | 136736 | 169 | 70791526 |
Haematochezia | 34.19 | 9.55 | 55 | 136694 | 73026 | 70718669 |
Anaphylactoid reaction | 33.93 | 9.55 | 45 | 136704 | 4962 | 70786733 |
Anal sphincter atony | 33.26 | 9.55 | 15 | 136734 | 310 | 70791385 |
Phrenic nerve paralysis | 33.26 | 9.55 | 15 | 136734 | 310 | 70791385 |
Product contamination microbial | 33.01 | 9.55 | 21 | 136728 | 883 | 70790812 |
Paraesthesia oral | 33 | 9.55 | 84 | 136665 | 15333 | 70776362 |
Blood lactic acid increased | 32.88 | 9.55 | 69 | 136680 | 11104 | 70780591 |
Troponin I increased | 32.70 | 9.55 | 40 | 136709 | 4068 | 70787627 |
Seasonal allergy | 32.62 | 9.55 | 77 | 136672 | 13407 | 70778288 |
Gas gangrene | 32.61 | 9.55 | 14 | 136735 | 256 | 70791439 |
Infection susceptibility increased | 32.42 | 9.55 | 34 | 136715 | 2923 | 70788772 |
Corneal reflex decreased | 32.16 | 9.55 | 15 | 136734 | 336 | 70791359 |
Oedema peripheral | 32.11 | 9.55 | 283 | 136466 | 227808 | 70563887 |
Blindness | 31.87 | 9.55 | 108 | 136641 | 23119 | 70768576 |
Uterine hypertonus | 31.83 | 9.55 | 14 | 136735 | 272 | 70791423 |
Hepatotoxicity | 31.81 | 9.55 | 23 | 136726 | 43963 | 70747732 |
Meningitis chemical | 31.81 | 9.55 | 13 | 136736 | 209 | 70791486 |
Blood cholesterol increased | 31.77 | 9.55 | 47 | 136702 | 64557 | 70727138 |
Confusional state | 31.34 | 9.55 | 374 | 136375 | 284024 | 70507671 |
Peripheral swelling | 30.93 | 9.55 | 299 | 136450 | 236264 | 70555431 |
Type I hypersensitivity | 30.79 | 9.55 | 37 | 136712 | 3695 | 70788000 |
Treatment failure | 30.74 | 9.55 | 158 | 136591 | 143984 | 70647711 |
Peripheral nerve injury | 30.64 | 9.55 | 18 | 136731 | 655 | 70791040 |
Drug resistance | 30.29 | 9.55 | 18 | 136731 | 38172 | 70753523 |
Fatigue | 30.26 | 9.55 | 1291 | 135458 | 823028 | 69968667 |
Abdominal pain upper | 30.06 | 9.55 | 234 | 136515 | 193368 | 70598327 |
Visual acuity reduced | 30.02 | 9.55 | 120 | 136629 | 27810 | 70763885 |
C-reactive protein increased | 29.73 | 9.55 | 111 | 136638 | 110406 | 70681289 |
Hepatocellular injury | 29.71 | 9.55 | 27 | 136722 | 46064 | 70745631 |
Melaena | 29.71 | 9.55 | 39 | 136710 | 56316 | 70735379 |
Pharyngeal swelling | 29.26 | 9.55 | 48 | 136701 | 6405 | 70785290 |
Platelet aggregation inhibition | 29.24 | 9.55 | 11 | 136738 | 140 | 70791555 |
Supraventricular tachycardia | 29.15 | 9.55 | 94 | 136655 | 19616 | 70772079 |
Liver injury | 28.97 | 9.55 | 22 | 136727 | 41013 | 70750682 |
Oculocardiac reflex | 28.81 | 9.55 | 9 | 136740 | 62 | 70791633 |
Death | 28.52 | 9.55 | 757 | 135992 | 509304 | 70282391 |
Myocardial ischaemia | 28.48 | 9.55 | 107 | 136642 | 24093 | 70767602 |
Migraine | 28.30 | 9.55 | 237 | 136512 | 72001 | 70719694 |
Abdominal pain | 28.12 | 9.55 | 477 | 136272 | 341650 | 70450045 |
Eye infection | 28.06 | 9.55 | 61 | 136688 | 10057 | 70781638 |
Tracheal deviation | 27.91 | 9.55 | 11 | 136738 | 160 | 70791535 |
Weight decreased | 27.81 | 9.55 | 426 | 136323 | 310062 | 70481633 |
Electrocardiogram T wave inversion | 27.80 | 9.55 | 41 | 136708 | 4990 | 70786705 |
Liver disorder | 27.26 | 9.55 | 48 | 136701 | 61520 | 70730175 |
Pupil fixed | 27.10 | 9.55 | 33 | 136716 | 3341 | 70788354 |
Tubulointerstitial nephritis | 27.07 | 9.55 | 15 | 136734 | 33061 | 70758634 |
Blood pH decreased | 26.96 | 9.55 | 38 | 136711 | 4438 | 70787257 |
Vasospasm | 26.69 | 9.55 | 19 | 136730 | 964 | 70790731 |
Respiratory failure | 26.50 | 9.55 | 465 | 136284 | 168270 | 70623425 |
White blood cell count decreased | 26.25 | 9.55 | 206 | 136543 | 169935 | 70621760 |
Upper airway obstruction | 26.20 | 9.55 | 21 | 136728 | 1275 | 70790420 |
Jaundice | 26.09 | 9.55 | 35 | 136714 | 50073 | 70741622 |
Dry gangrene | 26.04 | 9.55 | 18 | 136731 | 871 | 70790824 |
Wheezing | 26.02 | 9.55 | 287 | 136462 | 93883 | 70697812 |
Atrioventricular block complete | 25.85 | 9.55 | 76 | 136673 | 15087 | 70776608 |
Infusion site rash | 25.70 | 9.55 | 21 | 136728 | 1311 | 70790384 |
Spinal stroke | 25.56 | 9.55 | 7 | 136742 | 28 | 70791667 |
Food allergy | 25.50 | 9.55 | 53 | 136696 | 8471 | 70783224 |
Sensory loss | 25.26 | 9.55 | 63 | 136686 | 11356 | 70780339 |
Corneal epithelium defect | 25.00 | 9.55 | 16 | 136733 | 680 | 70791015 |
Product administration error | 24.96 | 9.55 | 118 | 136631 | 29405 | 70762290 |
Harlequin syndrome | 24.91 | 9.55 | 8 | 136741 | 61 | 70791634 |
Axillary nerve injury | 24.63 | 9.55 | 6 | 136743 | 13 | 70791682 |
Familial periodic paralysis | 24.45 | 9.55 | 10 | 136739 | 161 | 70791534 |
Agranulocytosis | 24.36 | 9.55 | 25 | 136724 | 40273 | 70751422 |
Spinal anaesthesia | 24.25 | 9.55 | 8 | 136741 | 67 | 70791628 |
Liver function test abnormal | 24.17 | 9.55 | 51 | 136698 | 61095 | 70730600 |
Constipation | 24.11 | 9.55 | 342 | 136407 | 252096 | 70539599 |
Drug abuse | 23.79 | 9.55 | 176 | 136573 | 147080 | 70644615 |
Plasma cell myeloma | 23.50 | 9.55 | 68 | 136681 | 73133 | 70718562 |
Insurance issue | 23.43 | 9.55 | 32 | 136717 | 3629 | 70788066 |
Red blood cell sedimentation rate increased | 23.32 | 9.55 | 24 | 136725 | 38618 | 70753077 |
Eosinophilia | 23.27 | 9.55 | 26 | 136723 | 40293 | 70751402 |
Distributive shock | 23.25 | 9.55 | 25 | 136724 | 2212 | 70789483 |
Vasoconstriction | 23.20 | 9.55 | 15 | 136734 | 649 | 70791046 |
PCO2 increased | 23.02 | 9.55 | 22 | 136727 | 1691 | 70790004 |
Lung hyperinflation | 22.94 | 9.55 | 22 | 136727 | 1699 | 70789996 |
Prostate cancer | 22.92 | 9.55 | 16 | 136733 | 31147 | 70760548 |
Propofol infusion syndrome | 22.85 | 9.55 | 22 | 136727 | 1707 | 70789988 |
Gastrointestinal haemorrhage | 22.79 | 9.55 | 163 | 136586 | 137245 | 70654450 |
Reversible cerebral vasoconstriction syndrome | 22.77 | 9.55 | 27 | 136722 | 2658 | 70789037 |
Neuromuscular blockade | 22.73 | 9.55 | 14 | 136735 | 556 | 70791139 |
Spinal cord oedema | 22.68 | 9.55 | 12 | 136737 | 355 | 70791340 |
Sinus bradycardia | 22.65 | 9.55 | 98 | 136651 | 23525 | 70768170 |
Extremity necrosis | 22.59 | 9.55 | 28 | 136721 | 2886 | 70788809 |
Compartment syndrome | 22.58 | 9.55 | 35 | 136714 | 4451 | 70787244 |
Cytomegalovirus infection | 22.55 | 9.55 | 26 | 136723 | 39732 | 70751963 |
Product preparation error | 22.49 | 9.55 | 35 | 136714 | 4467 | 70787228 |
Infusion site nodule | 22.44 | 9.55 | 11 | 136738 | 276 | 70791419 |
Brain oedema | 22.34 | 9.55 | 97 | 136652 | 23321 | 70768374 |
Fall | 22.28 | 9.55 | 669 | 136080 | 443427 | 70348268 |
Schizophrenia | 22.20 | 9.55 | 3 | 136746 | 16765 | 70774930 |
Status epilepticus | 22.19 | 9.55 | 100 | 136649 | 24426 | 70767269 |
Device ineffective | 22.17 | 9.55 | 9 | 136740 | 142 | 70791553 |
Diabetes mellitus | 22.13 | 9.55 | 68 | 136681 | 71756 | 70719939 |
Obesity | 22.11 | 9.55 | 12 | 136737 | 26759 | 70764936 |
Hypoglycaemia | 22.11 | 9.55 | 100 | 136649 | 94264 | 70697431 |
Coronary artery disease | 21.85 | 9.55 | 56 | 136693 | 62680 | 70729015 |
International normalised ratio increased | 21.76 | 9.55 | 81 | 136668 | 80645 | 70711050 |
PO2 decreased | 21.76 | 9.55 | 27 | 136722 | 2787 | 70788908 |
Hypercapnia | 21.73 | 9.55 | 49 | 136700 | 8280 | 70783415 |
Respiratory arrest | 21.69 | 9.55 | 178 | 136571 | 53755 | 70737940 |
Discomfort | 21.68 | 9.55 | 117 | 136632 | 105319 | 70686376 |
Rectal prolapse | 21.66 | 9.55 | 23 | 136726 | 2006 | 70789689 |
Sleep disorder | 21.64 | 9.55 | 66 | 136683 | 69806 | 70721889 |
Ventricular arrhythmia | 21.48 | 9.55 | 47 | 136702 | 7783 | 70783912 |
Inappropriate antidiuretic hormone secretion | 21.42 | 9.55 | 9 | 136740 | 23267 | 70768428 |
Injection site pain | 21.37 | 9.55 | 332 | 136417 | 117287 | 70674408 |
Irritable bowel syndrome | 21.31 | 9.55 | 41 | 136708 | 50809 | 70740886 |
BRASH syndrome | 21.30 | 9.55 | 14 | 136735 | 623 | 70791072 |
Foreign body | 21.27 | 9.55 | 26 | 136723 | 2642 | 70789053 |
Quadriplegia | 21.21 | 9.55 | 28 | 136721 | 3074 | 70788621 |
Pancreatitis acute | 21.18 | 9.55 | 34 | 136715 | 45190 | 70746505 |
Glucose tolerance impaired | 21.16 | 9.55 | 43 | 136706 | 6763 | 70784932 |
Nystagmus | 21.10 | 9.55 | 52 | 136697 | 9303 | 70782392 |
Pulmonary fibrosis | 21.06 | 9.55 | 21 | 136728 | 34289 | 70757406 |
Inhibitory drug interaction | 21.00 | 9.55 | 31 | 136718 | 3776 | 70787919 |
Cardio-respiratory arrest | 20.97 | 9.55 | 291 | 136458 | 100386 | 70691309 |
Blister | 20.97 | 9.55 | 111 | 136638 | 100415 | 70691280 |
Eyelid oedema | 20.95 | 9.55 | 63 | 136686 | 12664 | 70779031 |
Product administered at inappropriate site | 20.84 | 9.55 | 29 | 136720 | 3347 | 70788348 |
Pharyngitis streptococcal | 20.77 | 9.55 | 52 | 136697 | 9396 | 70782299 |
Fear of death | 20.54 | 9.55 | 19 | 136730 | 1402 | 70790293 |
Bursitis infective | 20.38 | 9.55 | 18 | 136731 | 1250 | 70790445 |
Ischaemia | 20.31 | 9.55 | 45 | 136704 | 7514 | 70784181 |
Pallor | 20.28 | 9.55 | 142 | 136607 | 40832 | 70750863 |
Abortion spontaneous | 20.27 | 9.55 | 13 | 136736 | 26466 | 70765229 |
Neoplasm progression | 20.26 | 9.55 | 35 | 136714 | 45193 | 70746502 |
Heart rate increased | 20.20 | 9.55 | 302 | 136447 | 105846 | 70685849 |
Pain in extremity | 20.17 | 9.55 | 480 | 136269 | 327602 | 70464093 |
Scar | 20.06 | 9.55 | 66 | 136683 | 13915 | 70777780 |
Gastrointestinal disorder | 20.05 | 9.55 | 120 | 136629 | 105307 | 70686388 |
Hypercalcaemia | 20.03 | 9.55 | 22 | 136727 | 34363 | 70757332 |
Parophthalmia | 20.00 | 9.55 | 11 | 136738 | 352 | 70791343 |
Osteonecrosis of jaw | 19.99 | 9.55 | 30 | 136719 | 40972 | 70750723 |
Infusion site discomfort | 19.97 | 9.55 | 16 | 136733 | 971 | 70790724 |
Arthritis bacterial | 19.90 | 9.55 | 47 | 136702 | 8186 | 70783509 |
Eyelid ptosis | 19.54 | 9.55 | 53 | 136696 | 10049 | 70781646 |
Neurotoxicity | 19.52 | 9.55 | 111 | 136638 | 29715 | 70761980 |
Administration site swelling | 19.45 | 9.55 | 11 | 136738 | 372 | 70791323 |
Metastases to liver | 19.41 | 9.55 | 13 | 136736 | 25865 | 70765830 |
Ascites | 19.39 | 9.55 | 66 | 136683 | 67481 | 70724214 |
Apnoeic attack | 19.34 | 9.55 | 13 | 136736 | 601 | 70791094 |
Administration site pain | 19.29 | 9.55 | 12 | 136737 | 485 | 70791210 |
Atonic urinary bladder | 19.29 | 9.55 | 7 | 136742 | 80 | 70791615 |
Product use issue | 19.28 | 9.55 | 238 | 136511 | 179699 | 70611996 |
Intracranial hypotension | 19.27 | 9.55 | 11 | 136738 | 379 | 70791316 |
Weight increased | 19.21 | 9.55 | 340 | 136409 | 241991 | 70549704 |
Dermatitis atopic | 19.20 | 9.55 | 49 | 136700 | 8958 | 70782737 |
Product dose omission issue | 19.15 | 9.55 | 552 | 136197 | 216916 | 70574779 |
Injection site inflammation | 18.97 | 9.55 | 28 | 136721 | 3410 | 70788285 |
Sinus arrest | 18.93 | 9.55 | 27 | 136722 | 3188 | 70788507 |
Aplastic anaemia | 18.92 | 9.55 | 73 | 136676 | 16643 | 70775052 |
Drug-induced liver injury | 18.84 | 9.55 | 51 | 136698 | 56062 | 70735633 |
Punctate keratitis | 18.80 | 9.55 | 15 | 136734 | 905 | 70790790 |
SARS-CoV-2 test false positive | 18.78 | 9.55 | 4 | 136745 | 3 | 70791692 |
Stomatitis | 18.71 | 9.55 | 158 | 136591 | 128353 | 70663342 |
Liquid product physical issue | 18.71 | 9.55 | 15 | 136734 | 911 | 70790784 |
Creatinine renal clearance decreased | 18.71 | 9.55 | 5 | 136744 | 17195 | 70774500 |
Pupillary reflex impaired | 18.68 | 9.55 | 27 | 136722 | 3227 | 70788468 |
Normal newborn | 18.64 | 9.55 | 39 | 136710 | 6261 | 70785434 |
Condition aggravated | 18.40 | 9.55 | 657 | 136092 | 426978 | 70364717 |
Progressive multifocal leukoencephalopathy | 18.38 | 9.55 | 7 | 136742 | 19207 | 70772488 |
Hypercholesterolaemia | 18.36 | 9.55 | 6 | 136743 | 18111 | 70773584 |
Procedural pain | 18.27 | 9.55 | 76 | 136673 | 17933 | 70773762 |
Accelerated idioventricular rhythm | 18.26 | 9.55 | 8 | 136741 | 154 | 70791541 |
Platelet count decreased | 18.25 | 9.55 | 238 | 136511 | 177984 | 70613711 |
Poor quality product administered | 18.20 | 9.55 | 27 | 136722 | 3304 | 70788391 |
Rotator cuff syndrome | 18.17 | 9.55 | 60 | 136689 | 12674 | 70779021 |
Balance disorder | 17.98 | 9.55 | 101 | 136648 | 90027 | 70701668 |
Arterial spasm | 17.89 | 9.55 | 8 | 136741 | 162 | 70791533 |
Myelosuppression | 17.88 | 9.55 | 19 | 136730 | 30126 | 70761569 |
Disease recurrence | 17.87 | 9.55 | 28 | 136721 | 37575 | 70754120 |
Systemic toxicity | 17.81 | 9.55 | 7 | 136742 | 101 | 70791594 |
Factor V Leiden mutation | 17.80 | 9.55 | 8 | 136741 | 164 | 70791531 |
Depressed mood | 17.78 | 9.55 | 36 | 136713 | 43784 | 70747911 |
Dermatitis contact | 17.72 | 9.55 | 50 | 136699 | 9699 | 70781996 |
Renal failure | 17.50 | 9.55 | 483 | 136266 | 188587 | 70603108 |
Eye inflammation | 17.46 | 9.55 | 35 | 136714 | 5452 | 70786243 |
No adverse event | 17.45 | 9.55 | 114 | 136635 | 32039 | 70759656 |
Swelling | 17.44 | 9.55 | 257 | 136492 | 188282 | 70603413 |
Postpartum disorder | 17.36 | 9.55 | 4 | 136745 | 6 | 70791689 |
Torsade de pointes | 17.25 | 9.55 | 75 | 136674 | 18041 | 70773654 |
Rheumatoid nodule | 17.12 | 9.55 | 4 | 136745 | 15063 | 70776632 |
Gastroenteritis | 17.08 | 9.55 | 21 | 136728 | 31192 | 70760503 |
Graft versus host disease | 17.05 | 9.55 | 4 | 136745 | 15019 | 70776676 |
Suicide attempt | 17.03 | 9.55 | 87 | 136662 | 79423 | 70712272 |
Loss of personal independence in daily activities | 17.02 | 9.55 | 95 | 136654 | 84815 | 70706880 |
Brain injury | 16.95 | 9.55 | 52 | 136697 | 10565 | 70781130 |
Infection | 16.94 | 9.55 | 295 | 136454 | 210490 | 70581205 |
Myocardial stunning | 16.92 | 9.55 | 8 | 136741 | 185 | 70791510 |
Amaurosis | 16.82 | 9.55 | 15 | 136734 | 1055 | 70790640 |
Pneumocephalus | 16.80 | 9.55 | 9 | 136740 | 273 | 70791422 |
Glossoptosis | 16.76 | 9.55 | 8 | 136741 | 189 | 70791506 |
Injection site joint infection | 16.74 | 9.55 | 5 | 136744 | 29 | 70791666 |
Pneumocystis jirovecii pneumonia | 16.71 | 9.55 | 20 | 136729 | 30062 | 70761633 |
Irregular breathing | 16.69 | 9.55 | 11 | 136738 | 492 | 70791203 |
Poisoning deliberate | 16.69 | 9.55 | 6 | 136743 | 17054 | 70774641 |
Diplopia | 16.64 | 9.55 | 102 | 136647 | 28045 | 70763650 |
Monoplegia | 16.45 | 9.55 | 27 | 136722 | 3604 | 70788091 |
Laryngospasm | 16.38 | 9.55 | 27 | 136722 | 3616 | 70788079 |
Mental status changes | 16.38 | 9.55 | 190 | 136559 | 62911 | 70728784 |
Diplegia | 16.38 | 9.55 | 18 | 136731 | 1632 | 70790063 |
Gamma-glutamyltransferase increased | 16.33 | 9.55 | 47 | 136702 | 50638 | 70741057 |
Epinephrine increased | 16.32 | 9.55 | 4 | 136745 | 9 | 70791686 |
Hip arthroplasty | 16.27 | 9.55 | 18 | 136731 | 28022 | 70763673 |
Urticaria chronic | 16.26 | 9.55 | 11 | 136738 | 514 | 70791181 |
Coagulation factor deficiency | 16.21 | 9.55 | 7 | 136742 | 130 | 70791565 |
Diabetes mellitus inadequate control | 16.17 | 9.55 | 12 | 136737 | 22633 | 70769062 |
Catecholamine crisis | 16.06 | 9.55 | 5 | 136744 | 34 | 70791661 |
Vitamin D increased | 16.01 | 9.55 | 11 | 136738 | 527 | 70791168 |
Foot deformity | 16.01 | 9.55 | 10 | 136739 | 20645 | 70771050 |
Cardiopulmonary failure | 15.93 | 9.55 | 37 | 136712 | 6373 | 70785322 |
Device malfunction | 15.93 | 9.55 | 76 | 136673 | 19008 | 70772687 |
Dehydration | 15.85 | 9.55 | 324 | 136425 | 225818 | 70565877 |
Phaeochromocytoma crisis | 15.84 | 9.55 | 9 | 136740 | 307 | 70791388 |
Inflammation | 15.78 | 9.55 | 88 | 136661 | 78577 | 70713118 |
Application site pallor | 15.76 | 9.55 | 3 | 136746 | 0 | 70791695 |
Hypercatabolism | 15.76 | 9.55 | 3 | 136746 | 0 | 70791695 |
Troponin T increased | 15.75 | 9.55 | 22 | 136727 | 2548 | 70789147 |
Blood pressure increased | 15.64 | 9.55 | 475 | 136274 | 188042 | 70603653 |
Hepatitis | 15.63 | 9.55 | 47 | 136702 | 49933 | 70741762 |
Postresuscitation encephalopathy | 15.58 | 9.55 | 5 | 136744 | 38 | 70791657 |
Headache | 15.58 | 9.55 | 1310 | 135439 | 579095 | 70212600 |
Pancreatic carcinoma | 15.53 | 9.55 | 3 | 136746 | 12901 | 70778794 |
Acute pulmonary oedema | 15.53 | 9.55 | 59 | 136690 | 13353 | 70778342 |
Neutropenic sepsis | 15.47 | 9.55 | 15 | 136734 | 24815 | 70766880 |
Hepatic cirrhosis | 15.46 | 9.55 | 22 | 136727 | 30709 | 70760986 |
Swelling face | 15.43 | 9.55 | 188 | 136561 | 62976 | 70728719 |
Retinal vascular occlusion | 15.42 | 9.55 | 11 | 136738 | 560 | 70791135 |
Spinal epidural haemorrhage | 15.42 | 9.55 | 7 | 136742 | 147 | 70791548 |
Malaise | 15.40 | 9.55 | 680 | 136069 | 432252 | 70359443 |
Lung neoplasm malignant | 15.35 | 9.55 | 15 | 136734 | 24727 | 70766968 |
Staphylococcal infection | 15.32 | 9.55 | 164 | 136585 | 53240 | 70738455 |
Myelodysplastic syndrome | 15.31 | 9.55 | 21 | 136728 | 29764 | 70761931 |
Application site alopecia | 15.25 | 9.55 | 4 | 136745 | 13 | 70791682 |
Inadequate analgesia | 15.21 | 9.55 | 28 | 136721 | 4094 | 70787601 |
Palmar-plantar erythrodysaesthesia syndrome | 14.87 | 9.55 | 22 | 136727 | 30225 | 70761470 |
Chest discomfort | 14.87 | 9.55 | 329 | 136420 | 124052 | 70667643 |
Neuroleptic malignant syndrome | 14.76 | 9.55 | 17 | 136732 | 25990 | 70765705 |
Neurogenic shock | 14.74 | 9.55 | 11 | 136738 | 601 | 70791094 |
ECG signs of myocardial ischaemia | 14.71 | 9.55 | 9 | 136740 | 353 | 70791342 |
Haemoglobin decreased | 14.66 | 9.55 | 293 | 136456 | 204866 | 70586829 |
Capillary nail refill test abnormal | 14.65 | 9.55 | 5 | 136744 | 47 | 70791648 |
Blindness cortical | 14.63 | 9.55 | 13 | 136736 | 910 | 70790785 |
Exposure during pregnancy | 14.58 | 9.55 | 244 | 136505 | 87473 | 70704222 |
Skin test positive | 14.50 | 9.55 | 14 | 136735 | 1090 | 70790605 |
Diabetic ketoacidosis | 14.47 | 9.55 | 24 | 136725 | 31488 | 70760207 |
Arthritis infective | 14.45 | 9.55 | 39 | 136710 | 7373 | 70784322 |
Foetal heart rate abnormal | 14.44 | 9.55 | 8 | 136741 | 260 | 70791435 |
Obstructive airways disorder | 14.43 | 9.55 | 93 | 136656 | 26020 | 70765675 |
Adverse event | 14.42 | 9.55 | 48 | 136701 | 49413 | 70742282 |
Tracheitis | 14.34 | 9.55 | 15 | 136734 | 1286 | 70790409 |
Nail bed tenderness | 14.22 | 9.55 | 9 | 136740 | 375 | 70791320 |
Product prescribing error | 14.16 | 9.55 | 34 | 136715 | 38918 | 70752777 |
Seizure like phenomena | 14.14 | 9.55 | 17 | 136732 | 1698 | 70789997 |
Cholestasis of pregnancy | 14.09 | 9.55 | 13 | 136736 | 956 | 70790739 |
Radiculopathy | 14.06 | 9.55 | 34 | 136715 | 6011 | 70785684 |
Epidural analgesia | 14.03 | 9.55 | 5 | 136744 | 54 | 70791641 |
Bone marrow failure | 13.99 | 9.55 | 48 | 136701 | 48962 | 70742733 |
Meningitis | 13.98 | 9.55 | 43 | 136706 | 8750 | 70782945 |
Respiratory tract infection bacterial | 13.97 | 9.55 | 17 | 136732 | 1720 | 70789975 |
Left ventricular dysfunction | 13.91 | 9.55 | 70 | 136679 | 17887 | 70773808 |
Incision site rash | 13.88 | 9.55 | 4 | 136745 | 20 | 70791675 |
Trigeminal palsy | 13.88 | 9.55 | 4 | 136745 | 20 | 70791675 |
Skin ulcer | 13.85 | 9.55 | 47 | 136702 | 48098 | 70743597 |
Enzyme induction | 13.81 | 9.55 | 6 | 136743 | 113 | 70791582 |
Kidney infection | 13.80 | 9.55 | 74 | 136675 | 19381 | 70772314 |
Injection site necrosis | 13.79 | 9.55 | 15 | 136734 | 1344 | 70790351 |
Cranial nerve palsies multiple | 13.77 | 9.55 | 6 | 136743 | 114 | 70791581 |
Rash | 13.75 | 9.55 | 825 | 135924 | 509737 | 70281958 |
Hypomagnesaemia | 13.73 | 9.55 | 37 | 136712 | 40727 | 70750968 |
Forced vital capacity abnormal | 13.72 | 9.55 | 4 | 136745 | 21 | 70791674 |
Caffeine allergy | 13.72 | 9.55 | 4 | 136745 | 21 | 70791674 |
Treatment noncompliance | 13.71 | 9.55 | 45 | 136704 | 46529 | 70745166 |
Immune reconstitution inflammatory syndrome | 13.71 | 9.55 | 4 | 136745 | 12986 | 70778709 |
Removal of foreign body from throat | 13.69 | 9.55 | 3 | 136746 | 3 | 70791692 |
Sinus operation | 13.68 | 9.55 | 18 | 136731 | 1969 | 70789726 |
Airway complication of anaesthesia | 13.60 | 9.55 | 9 | 136740 | 405 | 70791290 |
Paranasal cyst | 13.52 | 9.55 | 9 | 136740 | 409 | 70791286 |
Therapeutic product effect prolonged | 13.50 | 9.55 | 10 | 136739 | 540 | 70791155 |
Dry mouth | 13.50 | 9.55 | 80 | 136669 | 70377 | 70721318 |
Allodynia | 13.49 | 9.55 | 15 | 136734 | 1378 | 70790317 |
Exophthalmos | 13.47 | 9.55 | 16 | 136733 | 1578 | 70790117 |
Cardiac assistance device user | 13.41 | 9.55 | 5 | 136744 | 62 | 70791633 |
Optic atrophy | 13.37 | 9.55 | 17 | 136732 | 1798 | 70789897 |
Vocal cord disorder | 13.33 | 9.55 | 15 | 136734 | 1396 | 70790299 |
Skin infection | 13.33 | 9.55 | 64 | 136685 | 16048 | 70775647 |
Air embolism | 13.31 | 9.55 | 9 | 136740 | 420 | 70791275 |
Alanine aminotransferase increased | 13.30 | 9.55 | 202 | 136547 | 147278 | 70644417 |
Pupillary light reflex tests abnormal | 13.28 | 9.55 | 8 | 136741 | 305 | 70791390 |
Atrophy of globe | 13.27 | 9.55 | 5 | 136744 | 64 | 70791631 |
Pneumonia mycoplasmal | 13.24 | 9.55 | 15 | 136734 | 1406 | 70790289 |
Prescribed underdose | 13.23 | 9.55 | 13 | 136736 | 21372 | 70770323 |
Post lumbar puncture syndrome | 13.21 | 9.55 | 11 | 136738 | 705 | 70790990 |
Hypoventilation | 13.20 | 9.55 | 35 | 136714 | 6547 | 70785148 |
Myocardial necrosis marker increased | 13.14 | 9.55 | 22 | 136727 | 2984 | 70788711 |
Bundle branch block left | 13.09 | 9.55 | 47 | 136702 | 10352 | 70781343 |
Cold sweat | 12.95 | 9.55 | 66 | 136683 | 16950 | 70774745 |
Infusion site reaction | 12.94 | 9.55 | 21 | 136728 | 2776 | 70788919 |
Vascular resistance systemic decreased | 12.90 | 9.55 | 7 | 136742 | 218 | 70791477 |
Peritonitis | 12.89 | 9.55 | 19 | 136730 | 26140 | 70765555 |
Optic nerve injury | 12.83 | 9.55 | 10 | 136739 | 583 | 70791112 |
Hypocalcaemia | 12.76 | 9.55 | 44 | 136705 | 44815 | 70746880 |
Injury corneal | 12.73 | 9.55 | 5 | 136744 | 72 | 70791623 |
Ocular retrobulbar haemorrhage | 12.72 | 9.55 | 6 | 136743 | 138 | 70791557 |
Vocal cord dysfunction | 12.71 | 9.55 | 9 | 136740 | 453 | 70791242 |
Oxygen saturation decreased | 12.69 | 9.55 | 304 | 136445 | 116125 | 70675570 |
Chemical burn | 12.69 | 9.55 | 9 | 136740 | 454 | 70791241 |
Conjunctival oedema | 12.63 | 9.55 | 13 | 136736 | 1093 | 70790602 |
Oxidative stress | 12.63 | 9.55 | 4 | 136745 | 29 | 70791666 |
Eye infection intraocular | 12.51 | 9.55 | 4 | 136745 | 30 | 70791665 |
Cardiac failure | 12.47 | 9.55 | 198 | 136551 | 143343 | 70648352 |
Product contamination | 12.47 | 9.55 | 13 | 136736 | 1110 | 70790585 |
Macroglossia | 12.39 | 9.55 | 13 | 136736 | 1118 | 70790577 |
Mania | 12.39 | 9.55 | 9 | 136740 | 17165 | 70774530 |
Respiratory tract oedema | 12.34 | 9.55 | 11 | 136738 | 773 | 70790922 |
Foreign body in respiratory tract | 12.31 | 9.55 | 8 | 136741 | 349 | 70791346 |
Injection site extravasation | 12.29 | 9.55 | 41 | 136708 | 8705 | 70782990 |
Central venous catheter removal | 12.27 | 9.55 | 9 | 136740 | 479 | 70791216 |
Lung disorder | 12.22 | 9.55 | 81 | 136668 | 69403 | 70722292 |
Poor quality sleep | 12.19 | 9.55 | 74 | 136675 | 20275 | 70771420 |
Nodal rhythm | 12.17 | 9.55 | 21 | 136728 | 2920 | 70788775 |
Gait disturbance | 12.15 | 9.55 | 268 | 136481 | 184838 | 70606857 |
Vitreous disorder | 12.14 | 9.55 | 7 | 136742 | 246 | 70791449 |
Spinal epidural haematoma | 12.13 | 9.55 | 14 | 136735 | 1339 | 70790356 |
Areflexia | 12.12 | 9.55 | 29 | 136720 | 5093 | 70786602 |
Anal ulcer | 12.10 | 9.55 | 13 | 136736 | 1149 | 70790546 |
Erythema | 12.09 | 9.55 | 485 | 136264 | 199078 | 70592617 |
Oral herpes | 12.08 | 9.55 | 84 | 136665 | 24102 | 70767593 |
Product preparation issue | 12.07 | 9.55 | 12 | 136737 | 968 | 70790727 |
End-tidal CO2 decreased | 12.07 | 9.55 | 4 | 136745 | 34 | 70791661 |
Abnormal behaviour | 12.07 | 9.55 | 31 | 136718 | 34678 | 70757017 |
Streptococcal infection | 12.06 | 9.55 | 38 | 136711 | 7833 | 70783862 |
Product use in unapproved indication | 12.06 | 9.55 | 502 | 136247 | 206976 | 70584719 |
Chills | 12.05 | 9.55 | 365 | 136384 | 144421 | 70647274 |
Infusion site irritation | 11.88 | 9.55 | 9 | 136740 | 503 | 70791192 |
Intra-ocular injection complication | 11.87 | 9.55 | 4 | 136745 | 36 | 70791659 |
Intraocular pressure increased | 11.87 | 9.55 | 41 | 136708 | 8860 | 70782835 |
Autonomic nervous system imbalance | 11.85 | 9.55 | 26 | 136723 | 4313 | 70787382 |
Tongue pruritus | 11.83 | 9.55 | 9 | 136740 | 506 | 70791189 |
Malignant melanoma | 11.82 | 9.55 | 6 | 136743 | 13894 | 70777801 |
Vitreous floaters | 11.81 | 9.55 | 34 | 136715 | 6670 | 70785025 |
Injection site atrophy | 11.80 | 9.55 | 8 | 136741 | 375 | 70791320 |
Transient ischaemic attack | 11.80 | 9.55 | 47 | 136702 | 45897 | 70745798 |
Renal cancer | 11.79 | 9.55 | 4 | 136745 | 11792 | 70779903 |
Depression | 11.69 | 9.55 | 293 | 136456 | 198681 | 70593014 |
Photosensitivity reaction | 11.69 | 9.55 | 12 | 136737 | 19328 | 70772367 |
Retinal haemorrhage | 11.61 | 9.55 | 37 | 136712 | 7673 | 70784022 |
Opisthotonus | 11.60 | 9.55 | 10 | 136739 | 672 | 70791023 |
Dermatitis exfoliative | 11.60 | 9.55 | 3 | 136746 | 10548 | 70781147 |
Post transplant lymphoproliferative disorder | 11.59 | 9.55 | 3 | 136746 | 10542 | 70781153 |
SARS-CoV-2 test positive | 11.54 | 9.55 | 40 | 136709 | 8661 | 70783034 |
Thermal burn | 11.53 | 9.55 | 33 | 136716 | 6453 | 70785242 |
Blood creatine phosphokinase increased | 11.50 | 9.55 | 70 | 136679 | 61193 | 70730502 |
Hallucination, auditory | 11.50 | 9.55 | 11 | 136738 | 18317 | 70773378 |
Femoral nerve injury | 11.50 | 9.55 | 4 | 136745 | 40 | 70791655 |
Anaphylactoid syndrome of pregnancy | 11.50 | 9.55 | 4 | 136745 | 40 | 70791655 |
Angina pectoris | 11.50 | 9.55 | 51 | 136698 | 48332 | 70743363 |
Breast cancer female | 11.49 | 9.55 | 3 | 136746 | 10483 | 70781212 |
Hepatitis cholestatic | 11.47 | 9.55 | 5 | 136744 | 12645 | 70779050 |
Procedural anxiety | 11.45 | 9.55 | 10 | 136739 | 684 | 70791011 |
Muscle tightness | 11.43 | 9.55 | 49 | 136700 | 11713 | 70779982 |
Colour blindness | 11.41 | 9.55 | 8 | 136741 | 396 | 70791299 |
Myocardial infarction | 11.41 | 9.55 | 248 | 136501 | 171397 | 70620298 |
Cholangitis | 11.40 | 9.55 | 4 | 136745 | 11545 | 70780150 |
XIIth nerve injury | 11.38 | 9.55 | 3 | 136746 | 10 | 70791685 |
Coagulation factor V level abnormal | 11.32 | 9.55 | 4 | 136745 | 42 | 70791653 |
Local reaction | 11.31 | 9.55 | 9 | 136740 | 541 | 70791154 |
Post procedural haemorrhage | 11.30 | 9.55 | 52 | 136697 | 12814 | 70778881 |
Extrasystoles | 11.29 | 9.55 | 34 | 136715 | 6840 | 70784855 |
Colitis ulcerative | 11.26 | 9.55 | 31 | 136718 | 33892 | 70757803 |
Cognitive disorder | 11.26 | 9.55 | 70 | 136679 | 60886 | 70730809 |
Bladder cancer | 11.23 | 9.55 | 10 | 136739 | 17232 | 70774463 |
Quadriparesis | 11.21 | 9.55 | 21 | 136728 | 3112 | 70788583 |
Reperfusion arrhythmia | 11.21 | 9.55 | 7 | 136742 | 285 | 70791410 |
Proteinuria | 11.19 | 9.55 | 25 | 136724 | 29349 | 70762346 |
Intentional product misuse to child | 11.19 | 9.55 | 5 | 136744 | 101 | 70791594 |
Insomnia | 11.17 | 9.55 | 327 | 136422 | 217479 | 70574216 |
Electrocardiogram ST-T segment depression | 11.16 | 9.55 | 3 | 136746 | 11 | 70791684 |
Polyneuropathy | 11.10 | 9.55 | 15 | 136734 | 21400 | 70770295 |
Fluid retention | 11.09 | 9.55 | 74 | 136675 | 63311 | 70728384 |
Symblepharon | 11.08 | 9.55 | 6 | 136743 | 186 | 70791509 |
Gait inability | 11.04 | 9.55 | 50 | 136699 | 47125 | 70744570 |
Disseminated intravascular coagulation | 10.99 | 9.55 | 106 | 136643 | 33492 | 70758203 |
Retinal ischaemia | 10.97 | 9.55 | 10 | 136739 | 724 | 70790971 |
Rectal haemorrhage | 10.96 | 9.55 | 78 | 136671 | 65753 | 70725942 |
Administration site discolouration | 10.95 | 9.55 | 3 | 136746 | 12 | 70791683 |
Infusion site scar | 10.93 | 9.55 | 7 | 136742 | 298 | 70791397 |
Limb injury | 10.90 | 9.55 | 86 | 136663 | 25666 | 70766029 |
Oropharyngeal discomfort | 10.87 | 9.55 | 31 | 136718 | 6048 | 70785647 |
Unwanted awareness during anaesthesia | 10.82 | 9.55 | 7 | 136742 | 303 | 70791392 |
Blood pressure fluctuation | 10.78 | 9.55 | 68 | 136681 | 58944 | 70732751 |
Product measured potency issue | 10.77 | 9.55 | 6 | 136743 | 197 | 70791498 |
Victim of spousal abuse | 10.76 | 9.55 | 3 | 136746 | 13 | 70791682 |
Myopathy | 10.74 | 9.55 | 12 | 136737 | 18600 | 70773095 |
Electrocardiogram P wave abnormal | 10.74 | 9.55 | 7 | 136742 | 307 | 70791388 |
Pain in jaw | 10.74 | 9.55 | 44 | 136705 | 42625 | 70749070 |
Body dysmorphic disorder | 10.70 | 9.55 | 7 | 136742 | 309 | 70791386 |
Flushing | 10.68 | 9.55 | 220 | 136529 | 81952 | 70709743 |
Heparin-induced thrombocytopenia | 10.67 | 9.55 | 40 | 136709 | 8997 | 70782698 |
Hyperkalaemia | 10.66 | 9.55 | 143 | 136606 | 106448 | 70685247 |
Concomitant disease aggravated | 10.65 | 9.55 | 5 | 136744 | 12109 | 70779586 |
Bradyphrenia | 10.61 | 9.55 | 3 | 136746 | 9943 | 70781752 |
Type IV hypersensitivity reaction | 10.60 | 9.55 | 22 | 136727 | 3513 | 70788182 |
Ill-defined disorder | 10.57 | 9.55 | 62 | 136687 | 54679 | 70737016 |
Non-infectious endophthalmitis | 10.56 | 9.55 | 7 | 136742 | 316 | 70791379 |
Myokymia | 10.56 | 9.55 | 5 | 136744 | 116 | 70791579 |
Laryngeal obstruction | 10.56 | 9.55 | 5 | 136744 | 116 | 70791579 |
Electrocardiogram T wave amplitude decreased | 10.54 | 9.55 | 9 | 136740 | 597 | 70791098 |
Mastocytosis | 10.45 | 9.55 | 8 | 136741 | 454 | 70791241 |
Nervous system disorder | 10.42 | 9.55 | 81 | 136668 | 24065 | 70767630 |
Madarosis | 10.42 | 9.55 | 18 | 136731 | 2505 | 70789190 |
Coccygectomy | 10.41 | 9.55 | 3 | 136746 | 15 | 70791680 |
Gastroenteritis viral | 10.41 | 9.55 | 74 | 136675 | 21381 | 70770314 |
Blood alkaline phosphatase increased | 10.40 | 9.55 | 68 | 136681 | 58453 | 70733242 |
pH body fluid abnormal | 10.37 | 9.55 | 5 | 136744 | 121 | 70791574 |
Incorrect product formulation administered | 10.37 | 9.55 | 5 | 136744 | 121 | 70791574 |
Enthesopathy | 10.33 | 9.55 | 4 | 136745 | 10865 | 70780830 |
Electrocardiogram U wave present | 10.29 | 9.55 | 5 | 136744 | 123 | 70791572 |
Post-anoxic myoclonus | 10.29 | 9.55 | 4 | 136745 | 56 | 70791639 |
Injection site oedema | 10.28 | 9.55 | 12 | 136737 | 1162 | 70790533 |
Glycosylated haemoglobin increased | 10.27 | 9.55 | 11 | 136738 | 17380 | 70774315 |
Larynx irritation | 10.25 | 9.55 | 5 | 136744 | 124 | 70791571 |
Immunisation reaction | 10.22 | 9.55 | 6 | 136743 | 218 | 70791477 |
Corneal opacity | 10.21 | 9.55 | 11 | 136738 | 975 | 70790720 |
Hepatic cancer | 10.19 | 9.55 | 3 | 136746 | 9680 | 70782015 |
Acute hepatic failure | 10.18 | 9.55 | 24 | 136725 | 27648 | 70764047 |
Administration related reaction | 10.18 | 9.55 | 5 | 136744 | 126 | 70791569 |
Nasal discharge discolouration | 10.15 | 9.55 | 16 | 136733 | 2065 | 70789630 |
CSF pressure increased | 10.12 | 9.55 | 6 | 136743 | 222 | 70791473 |
Injection site nerve damage | 10.10 | 9.55 | 4 | 136745 | 59 | 70791636 |
Sedation | 10.08 | 9.55 | 51 | 136698 | 46680 | 70745015 |
Sensorimotor disorder | 10.07 | 9.55 | 10 | 136739 | 806 | 70790889 |
Lymphoma | 10.03 | 9.55 | 9 | 136740 | 15453 | 70776242 |
Panniculitis | 10.03 | 9.55 | 4 | 136745 | 10672 | 70781023 |
Corneal abrasion | 10.03 | 9.55 | 11 | 136738 | 995 | 70790700 |
Arthritis | 9.97 | 9.55 | 131 | 136618 | 97849 | 70693846 |
Product confusion | 9.96 | 9.55 | 3 | 136746 | 18 | 70791677 |
Drug level decreased | 9.94 | 9.55 | 6 | 136743 | 12618 | 70779077 |
Behaviour disorder | 9.91 | 9.55 | 28 | 136721 | 5436 | 70786259 |
Cardiac procedure complication | 9.87 | 9.55 | 7 | 136742 | 353 | 70791342 |
Lymphopenia | 9.85 | 9.55 | 24 | 136725 | 27335 | 70764360 |
Vaginal abscess | 9.79 | 9.55 | 7 | 136742 | 358 | 70791337 |
Vascular malformation | 9.79 | 9.55 | 7 | 136742 | 358 | 70791337 |
Haematuria | 9.78 | 9.55 | 77 | 136672 | 63496 | 70728199 |
Heart rate decreased | 9.76 | 9.55 | 171 | 136578 | 61844 | 70729851 |
Lupus-like syndrome | 9.75 | 9.55 | 5 | 136744 | 11510 | 70780185 |
Product formulation issue | 9.73 | 9.55 | 10 | 136739 | 840 | 70790855 |
Hepatic function abnormal | 9.71 | 9.55 | 84 | 136665 | 67912 | 70723783 |
Serotonin syndrome | 9.71 | 9.55 | 124 | 136625 | 41990 | 70749705 |
Troponin increased | 9.69 | 9.55 | 60 | 136689 | 16554 | 70775141 |
N-terminal prohormone brain natriuretic peptide | 9.69 | 9.55 | 4 | 136745 | 66 | 70791629 |
Product distribution issue | 9.69 | 9.55 | 11 | 136738 | 1034 | 70790661 |
No reaction on previous exposure to drug | 9.57 | 9.55 | 6 | 136743 | 246 | 70791449 |
Diffuse large B-cell lymphoma | 9.56 | 9.55 | 7 | 136742 | 13295 | 70778400 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Methaemoglobinaemia | 32.77 | 29.15 | 10 | 151 | 71 | 89560 |
Cardiac arrest neonatal | 31.31 | 29.15 | 10 | 151 | 84 | 89547 |
Source | Code | Description |
---|---|---|
ATC | A01AD01 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Other agents for local oral treatment |
ATC | B02BC09 | BLOOD AND BLOOD FORMING ORGANS ANTIHEMORRHAGICS VITAMIN K AND OTHER HEMOSTATICS Local hemostatics |
ATC | C01CA24 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES Adrenergic and dopaminergic agents |
ATC | R01AA14 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Sympathomimetics, plain |
ATC | R03AA01 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Alpha- and beta-adrenoreceptor agonists |
ATC | R03AK01 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
ATC | S01EA01 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Sympathomimetics in glaucoma therapy |
ATC | S01EA51 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Sympathomimetics in glaucoma therapy |
FDA CS | M0003647 | Catecholamines |
FDA MoA | N0000000209 | Adrenergic alpha-Agonists |
FDA MoA | N0000000245 | Adrenergic beta-Agonists |
FDA EPC | N0000175552 | alpha-Adrenergic Agonist |
FDA EPC | N0000175555 | beta-Adrenergic Agonist |
FDA EPC | N0000175570 | Catecholamine |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D000322 | Adrenergic Agonists |
MeSH PA | D000316 | Adrenergic alpha-Agonists |
MeSH PA | D000318 | Adrenergic beta-Agonists |
MeSH PA | D018927 | Anti-Asthmatic Agents |
MeSH PA | D001993 | Bronchodilator Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D009184 | Mydriatics |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D019141 | Respiratory System Agents |
MeSH PA | D013566 | Sympathomimetics |
MeSH PA | D014662 | Vasoconstrictor Agents |
CHEBI has role | CHEBI:24621 | hormones |
CHEBI has role | CHEBI:35522 | beta-adrenergic agonists |
CHEBI has role | CHEBI:35523 | bronchodilator |
CHEBI has role | CHEBI:35524 | sympathomimetic |
CHEBI has role | CHEBI:35569 | alpha-adrenergic agonists |
CHEBI has role | CHEBI:35620 | vasodilator agents |
CHEBI has role | CHEBI:37886 | adrenergic agonists |
CHEBI has role | CHEBI:50513 | mydriatics |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Bronchiectasis | indication | 12295008 | DOID:9563 |
Bronchitis | indication | 32398004 | DOID:6132 |
Anaphylaxis | indication | 39579001 | |
Local anesthesia, by infiltration | indication | 44596000 | |
Low blood pressure | indication | 45007003 | |
Wheezing | indication | 56018004 | |
Hypotension associated with septic shock | indication | 76571007 | |
Open-angle glaucoma | indication | 84494001 | DOID:1067 |
Pulmonary emphysema | indication | 87433001 | |
Dyspnea | indication | 267036007 | |
Exacerbation of asthma | indication | 281239006 | |
Asthma management | indication | 406162001 | |
Acute exacerbation of asthma | indication | 708038006 | |
Administration of Local Anesthetic Nerve Block | indication | ||
Allergic Reactions | indication | ||
Ventricular fibrillation | off-label use | 71908006 | |
Asthma | off-label use | 195967001 | DOID:2841 |
Local anesthesia | off-label use | 386761002 | |
Cardiac arrest | off-label use | 410429000 | DOID:0060319 |
Keratitis | contraindication | 5888003 | DOID:4677 |
Bacterial septicemia | contraindication | 10001005 | DOID:0040085 |
Sinus tachycardia | contraindication | 11092001 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Aphakia | contraindication | 24010005 | |
Complete atrioventricular block | contraindication | 27885002 | |
Shock | contraindication | 27942005 | |
Hypovolemia | contraindication | 28560003 | |
Hypercapnia | contraindication | 29596007 | |
Parkinsonism | contraindication | 32798002 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Retinal detachment | contraindication | 42059000 | DOID:5327 |
Hypokalemia | contraindication | 43339004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Stokes-Adams syndrome | contraindication | 46935006 | |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Atrial fibrillation | contraindication | 49436004 | DOID:0060224 |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Sinus bradycardia | contraindication | 49710005 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Iritis | contraindication | 65074000 | DOID:1406 |
Cerebral arteriosclerosis | contraindication | 65312002 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Wolff-Parkinson-White pattern | contraindication | 74390002 | DOID:384 |
Decreased respiratory function | contraindication | 80954004 | |
Cardiogenic shock | contraindication | 89138009 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Open wound | contraindication | 125643001 | |
Seizure disorder | contraindication | 128613002 | |
Bleeding | contraindication | 131148009 | |
Angina pectoris | contraindication | 194828000 | |
Primary dilated cardiomyopathy | contraindication | 195021004 | |
Partial atrioventricular block | contraindication | 195039008 | |
Heart block | contraindication | 233916004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Sepsis syndrome | contraindication | 238150007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Psychoneurotic personality disorder | contraindication | 268634009 | |
Deficiency of cholinesterase | contraindication | 360607009 | |
Hypoxia | contraindication | 389086002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Peripheral vascular disease | contraindication | 400047006 | |
Anterior uveitis | contraindication | 410692006 | DOID:1407 |
Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
Disorder of coronary artery | contraindication | 414024009 | |
Denuded skin | contraindication | 418242004 | |
Thrombosis | contraindication | 439127006 | |
Pupillary Block Glaucoma | contraindication | ||
Lidocaine Toxicity | contraindication | ||
Reduced Hepatic Blood Flow | contraindication | ||
Regional Anesthesia for Labor Pain | contraindication | ||
Occlusive Vascular Disease | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.97 | acidic |
pKa2 | 12.82 | acidic |
pKa3 | 13.64 | acidic |
pKa4 | 8.71 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9833573 | Nov. 23, 2024 | METHOD TO TREAT SEVERE ALLERGIC EMERGENCIES IN PATIENTS WEIGHING 7.5 TO 15 KG (16.5 TO 33 LBS) |
EQ 0.15MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9149579 | July 19, 2025 | METHOD OF TREATING ALLERGIC REACTION VIA INJECTION |
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9149579 | July 19, 2025 | METHOD OF TREATING ALLERGIC REACTION VIA INJECTION |
EQ 0.3MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9149579 | July 19, 2025 | METHOD OF TREATING ALLERGIC REACTION VIA INJECTION |
EQ 0.15MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9724471 | May 23, 2027 | METHOD FOR CONFIRMING DOSE DELIVERY |
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9724471 | May 23, 2027 | METHOD FOR CONFIRMING DOSE DELIVERY |
EQ 0.3MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9724471 | May 23, 2027 | METHOD FOR CONFIRMING DOSE DELIVERY |
1MG/ML (1MG/ML) | EPINEPHRINE | BPI LABS | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 10004700 | Aug. 14, 2034 | EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE 1), INCLUDING ANAPHYLAXIS; A METHOD OF TREATING ALLERGIC REACTION, ANAPHYLAXIS, ANAPHYLACTIC SHOCK, OR COMBINATION THEREOF BY AN INJECTION OF AT LEAST ONE DOSAGE OF THE INJECTABLE LIQUID PHARMACEUTICAL |
1MG/ML (1MG/ML) | EPINEPHRINE | BPI LABS | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 10039728 | Aug. 14, 2034 | INCREASING MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK |
1MG/ML (1MG/ML) | EPINEPHRINE | BPI LABS | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 9283197 | Aug. 15, 2034 | EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS |
1MG/ML (1MG/ML) | EPINEPHRINE | BPI LABS | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 9283197 | Aug. 15, 2034 | INCREASING MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK |
1MG/ML (1MG/ML) | EPINEPHRINE | BPI LABS | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 9283197 | Aug. 15, 2034 | INDUCTION AND MAINTENANCE OF MYDRIASIS DURING INTRAOCULAR SURGERY |
EQ 1MG BASE/ML (EQ 1MG BASE/ML) | ADRENALIN | PAR STERILE PRODUCTS | N204200 | Dec. 7, 2012 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS | 9295657 | March 13, 2035 | EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS |
EQ 30MG BASE/30ML (EQ 1MG BASE/ML) | ADRENALIN | PAR STERILE PRODUCTS | N204640 | Dec. 18, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS | 9295657 | March 13, 2035 | EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS |
0.15MG/0.3ML (0.15MG/0.3ML) | SYMJEPI | ADAMIS PHARMS CORP | N207534 | Sept. 27, 2018 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 11141540 | Oct. 20, 2036 | A METHOD FOR ADMINISTERING A THERAPEUTIC DOSE OF EPINEPHRINE |
0.3MG/0.3ML (0.3MG/0.3ML) | SYMJEPI | ADAMIS PHARMS CORP | N207534 | June 15, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 11141540 | Oct. 20, 2036 | A METHOD FOR ADMINISTERING A THERAPEUTIC DOSE OF EPINEPHRINE |
EQ 0.15MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 10688244 | Dec. 21, 2037 | METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR |
EQ 0.15MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 10842938 | Dec. 21, 2037 | METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR |
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 10688244 | Dec. 21, 2037 | METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR |
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 10842938 | Dec. 21, 2037 | METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Alpha-1D adrenergic receptor | GPCR | AGONIST | Ki | 6.66 | CHEMBL | CHEMBL | |||
Alpha-1B adrenergic receptor | GPCR | AGONIST | Ki | 6.50 | IUPHAR | CHEMBL | |||
Alpha-2A adrenergic receptor | GPCR | AGONIST | Ki | 6.56 | DRUG MATRIX | CHEMBL | |||
Beta-2 adrenergic receptor | GPCR | AGONIST | Kd | 6.20 | CHEMBL | CHEMBL | |||
Alpha-1A adrenergic receptor | GPCR | AGONIST | Ki | 5.70 | CHEMBL | CHEMBL | |||
Alpha-2B adrenergic receptor | GPCR | AGONIST | Ki | 6.40 | DRUG MATRIX | CHEMBL | |||
Alpha-2C adrenergic receptor | GPCR | AGONIST | Ki | 6.45 | DRUG MATRIX | CHEMBL | |||
Beta-1 adrenergic receptor | GPCR | Ki | 5.40 | PDSP | |||||
D(1A) dopamine receptor | GPCR | Kd | 4.26 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 6.04 | CHEMBL | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.43 | PDSP | |||||
Alpha-1D adrenergic receptor | GPCR | AGONIST | Ki | 6.30 | IUPHAR | ||||
Mu-type opioid receptor | GPCR | Ki | 5.40 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 5.96 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Ki | 6.18 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Ki | 6.14 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 5.52 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | Ki | 7.89 | CHEMBL | |||||
Adrenergic receptor beta | GPCR | IC50 | 4.54 | CHEMBL | |||||
M18 aspartyl aminopeptidase | Enzyme | IC50 | 5.52 | CHEMBL | |||||
Arachidonate 15-lipoxygenase | Enzyme | IC50 | 5.48 | DRUG MATRIX | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 6.01 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 6.20 | CHEMBL |
ID | Source |
---|---|
4018034 | VUID |
N0000146377 | NUI |
D00996 | KEGG_DRUG |
51-42-3 | SECONDARY_CAS_RN |
4018032 | VANDF |
4018033 | VANDF |
4018034 | VANDF |
C0014563 | UMLSCUI |
CHEBI:28918 | CHEBI |
ALE | PDB_CHEM_ID |
CHEMBL679 | ChEMBL_ID |
DB00668 | DRUGBANK_ID |
CHEMBL1256958 | ChEMBL_ID |
D004837 | MESH_DESCRIPTOR_UI |
5816 | PUBCHEM_CID |
2142 | INN_ID |
479 | IUPHAR_LIGAND_ID |
YKH834O4BH | UNII |
203180 | RXNORM |
3451 | MMSL |
3500 | MMSL |
4663 | MMSL |
4664 | MMSL |
4665 | MMSL |
4667 | MMSL |
72412 | MMSL |
d00699 | MMSL |
001774 | NDDF |
001776 | NDDF |
006223 | NDDF |
126134000 | SNOMEDCT_US |
387362001 | SNOMEDCT_US |
50685004 | SNOMEDCT_US |
65502005 | SNOMEDCT_US |
CHEMBL3183376 | ChEMBL_ID |
55-31-2 | SECONDARY_CAS_RN |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5985 | INJECTION | 0.15 mg | INTRAMUSCULAR | ANDA | 24 sections |
Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5986 | INJECTION | 0.30 mg | INTRAMUSCULAR | ANDA | 24 sections |
epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1694 | INJECTION | 0.30 mg | SUBCUTANEOUS | NDA AUTHORIZED GENERIC | 25 sections |
epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1695 | INJECTION | 0.15 mg | SUBCUTANEOUS | NDA AUTHORIZED GENERIC | 25 sections |
LIDOCAINE HCl and EPINEPHRINE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0264-9378 | INJECTION | 0.01 mg | EPIDURAL | ANDA | 12 sections |
Lidocaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0262 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 23 sections |
Lidocaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0262 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 23 sections |
Marcaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0557 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 19 sections |
Zorcaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0830 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | NDA | 29 sections |
Lidocaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0898 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 23 sections |
Lidocaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0898 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 23 sections |
Lignospan Standard | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-1095 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 23 sections |
Lignospan Standard | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-1095 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 23 sections |
Lignospan Forte | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-1096 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 23 sections |
Lignospan Forte | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-1096 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 23 sections |
Octocaine 50 | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9010 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 24 sections |
Vivacaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9011 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 19 sections |
Vivacaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9011 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 19 sections |
Vivacaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9011 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 19 sections |
Prilocaine Hydrochloride with Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9013 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 24 sections |
Octocaine 100 | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9023 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 24 sections |
Septocaine and Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9048 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | NDA | 29 sections |
Septocaine and Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9049 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | NDA | 29 sections |
LIDOCAINE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-6500 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 24 sections |
LIDOCAINE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-6500 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 24 sections |
Lidocaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-6512 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 24 sections |
Lidocaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-6512 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 24 sections |
Articaine Hydrochloride and Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-6620 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | NDA | 29 sections |
Articaine Hydrochloride and Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-6625 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | NDA | 29 sections |
Adrenalin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9810 | INJECTION | 1 mg | INTRAMUSCULAR | NDA | 15 sections |