Stem definition | Drug id | CAS RN |
---|---|---|
sympathomimetic, phenethyl derivatives | 1028 | 51-43-4 |
Dose | Unit | Route |
---|---|---|
0.50 | mg | P |
2.24 | mg | Inhal.aerosol |
20 | mg | Inhal.solution |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.09 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
S (Water solubility) | 0.18 mg/mL | Bocci G, Oprea TI, Benet LZ |
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 19, 1948 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sinusitis | 903.90 | 9.70 | 1687 | 134438 | 224966 | 63127931 |
Hereditary angioedema | 618.31 | 9.70 | 309 | 135816 | 7253 | 63345644 |
Local anaesthetic systemic toxicity | 500.82 | 9.70 | 149 | 135976 | 750 | 63352147 |
Stress cardiomyopathy | 491.64 | 9.70 | 286 | 135839 | 9164 | 63343733 |
Anaphylactic reaction | 433.16 | 9.70 | 617 | 135508 | 65483 | 63287414 |
Infusion site pain | 416.29 | 9.70 | 321 | 135804 | 16548 | 63336349 |
Contraindicated product administered | 378.18 | 9.70 | 22 | 136103 | 217626 | 63135271 |
Device failure | 372.43 | 9.70 | 204 | 135921 | 5807 | 63347090 |
Infusion site swelling | 361.52 | 9.70 | 238 | 135887 | 9532 | 63343365 |
Pemphigus | 355.30 | 9.70 | 8 | 136117 | 183718 | 63169179 |
Toxic anterior segment syndrome | 336.72 | 9.70 | 131 | 135994 | 1640 | 63351257 |
Infusion site erythema | 323.13 | 9.70 | 238 | 135887 | 11441 | 63341456 |
Drug intolerance | 316.41 | 9.70 | 133 | 135992 | 308528 | 63044369 |
Anaesthetic complication | 313.56 | 9.70 | 128 | 135997 | 1832 | 63351065 |
Infusion site extravasation | 307.84 | 9.70 | 221 | 135904 | 10205 | 63342692 |
Hand deformity | 304.26 | 9.70 | 8 | 136117 | 159449 | 63193448 |
COVID-19 | 297.11 | 9.70 | 711 | 135414 | 112392 | 63240505 |
Glossodynia | 296.28 | 9.70 | 23 | 136102 | 178853 | 63174044 |
Joint swelling | 283.94 | 9.70 | 176 | 135949 | 327490 | 63025407 |
Bronchitis | 281.66 | 9.70 | 741 | 135384 | 124194 | 63228703 |
Synovitis | 278.50 | 9.70 | 36 | 136089 | 186882 | 63166015 |
Kounis syndrome | 270.01 | 9.70 | 111 | 136014 | 1619 | 63351278 |
Infusion site pruritus | 268.06 | 9.70 | 165 | 135960 | 5870 | 63347027 |
Cardiac arrest | 244.32 | 9.70 | 583 | 135542 | 91962 | 63260935 |
Upper respiratory tract infection | 234.23 | 9.70 | 533 | 135592 | 81514 | 63271383 |
Systemic lupus erythematosus | 234.10 | 9.70 | 78 | 136047 | 208840 | 63144057 |
Anti-cyclic citrullinated peptide antibody positive | 233.13 | 9.70 | 3 | 136122 | 116209 | 63236688 |
Alopecia | 226.39 | 9.70 | 234 | 135891 | 337302 | 63015595 |
Anaphylactic shock | 217.66 | 9.70 | 261 | 135864 | 23372 | 63329525 |
Arthropathy | 214.77 | 9.70 | 118 | 136007 | 234674 | 63118223 |
Accidental exposure to product | 214.56 | 9.70 | 279 | 135846 | 27126 | 63325771 |
Ear infection | 202.23 | 9.70 | 323 | 135802 | 37890 | 63315007 |
Infusion site haemorrhage | 198.20 | 9.70 | 128 | 135997 | 4958 | 63347939 |
Hepatic enzyme increased | 198.01 | 9.70 | 93 | 136032 | 202235 | 63150662 |
Seasonal allergy | 189.06 | 9.70 | 229 | 135896 | 20721 | 63332176 |
Wound | 188.10 | 9.70 | 58 | 136067 | 163205 | 63189692 |
Pericarditis | 187.38 | 9.70 | 29 | 136096 | 131550 | 63221347 |
Illness | 178.59 | 9.70 | 352 | 135773 | 48707 | 63304190 |
Chondrolysis | 177.48 | 9.70 | 49 | 136076 | 178 | 63352719 |
Infusion site bruising | 173.33 | 9.70 | 106 | 136019 | 3726 | 63349171 |
Completed suicide | 172.83 | 9.70 | 49 | 136076 | 145624 | 63207273 |
Therapeutic product effect decreased | 172.45 | 9.70 | 100 | 136025 | 193087 | 63159810 |
Rheumatoid arthritis | 172.30 | 9.70 | 174 | 135951 | 253645 | 63099252 |
Rheumatoid factor positive | 165.79 | 9.70 | 3 | 136122 | 84403 | 63268494 |
Abdominal discomfort | 158.71 | 9.70 | 278 | 135847 | 320607 | 63032290 |
Insurance issue | 156.52 | 9.70 | 119 | 136006 | 6002 | 63346895 |
Respiratory tract infection | 151.42 | 9.70 | 298 | 135827 | 41185 | 63311712 |
Pulseless electrical activity | 149.21 | 9.70 | 126 | 135999 | 7395 | 63345502 |
General physical health deterioration | 144.90 | 9.70 | 131 | 135994 | 201271 | 63151626 |
Treatment failure | 143.75 | 9.70 | 129 | 135996 | 198914 | 63153983 |
Maternal exposure during delivery | 136.65 | 9.70 | 66 | 136059 | 1434 | 63351463 |
Impaired quality of life | 134.82 | 9.70 | 157 | 135968 | 13626 | 63339271 |
Bradycardia | 132.24 | 9.70 | 401 | 135724 | 72826 | 63280071 |
Product dose omission issue | 130.05 | 9.70 | 904 | 135221 | 233409 | 63119488 |
Headache | 125.81 | 9.70 | 1979 | 134146 | 631262 | 62721635 |
Incorrect drug administration rate | 121.60 | 9.70 | 86 | 136039 | 3876 | 63349021 |
Lagophthalmos | 121.55 | 9.70 | 41 | 136084 | 329 | 63352568 |
Folliculitis | 119.35 | 9.70 | 8 | 136117 | 70309 | 63282588 |
Helicobacter infection | 116.14 | 9.70 | 28 | 136097 | 92757 | 63260140 |
Ventricular tachycardia | 112.79 | 9.70 | 174 | 135951 | 19805 | 63333092 |
Hypotension | 111.55 | 9.70 | 980 | 135145 | 271624 | 63081273 |
Urticaria | 110.49 | 9.70 | 670 | 135455 | 165132 | 63187765 |
Infusion site mass | 105.99 | 9.70 | 62 | 136063 | 2006 | 63350891 |
Corneal oedema | 104.62 | 9.70 | 55 | 136070 | 1438 | 63351459 |
Product quality issue | 103.40 | 9.70 | 234 | 135891 | 35631 | 63317266 |
Inappropriate schedule of product administration | 102.99 | 9.70 | 469 | 135656 | 103496 | 63249401 |
Infusion site nodule | 101.82 | 9.70 | 54 | 136071 | 1438 | 63351459 |
Asthma | 101.79 | 9.70 | 541 | 135584 | 127020 | 63225877 |
Muscle injury | 101.18 | 9.70 | 11 | 136114 | 65334 | 63287563 |
Administration site swelling | 99.78 | 9.70 | 51 | 136074 | 1256 | 63351641 |
Arthralgia | 97.87 | 9.70 | 768 | 135357 | 568942 | 62783955 |
Urinary tract infection | 92.93 | 9.70 | 921 | 135204 | 263763 | 63089134 |
Impaired healing | 91.56 | 9.70 | 53 | 136072 | 102489 | 63250408 |
Musculoskeletal stiffness | 87.53 | 9.70 | 164 | 135961 | 184454 | 63168443 |
Bronchospasm | 87.23 | 9.70 | 143 | 135982 | 17137 | 63335760 |
Psoriatic arthropathy | 86.53 | 9.70 | 44 | 136081 | 91476 | 63261421 |
Cardiogenic shock | 83.33 | 9.70 | 143 | 135982 | 17789 | 63335108 |
Infusion site rash | 82.20 | 9.70 | 52 | 136073 | 1942 | 63350955 |
Fear | 81.65 | 9.70 | 132 | 135993 | 15634 | 63337263 |
Endophthalmitis | 81.36 | 9.70 | 65 | 136060 | 3527 | 63349370 |
Diarrhoea | 80.76 | 9.70 | 1066 | 135059 | 714300 | 62638597 |
Liver injury | 80.32 | 9.70 | 16 | 136109 | 60504 | 63292393 |
Rheumatic fever | 79.18 | 9.70 | 3 | 136122 | 43108 | 63309789 |
Multiple allergies | 79.02 | 9.70 | 121 | 136004 | 13681 | 63339216 |
Migraine | 76.83 | 9.70 | 430 | 135695 | 102916 | 63249981 |
Stridor | 76.28 | 9.70 | 62 | 136063 | 3448 | 63349449 |
Incorrect route of product administration | 75.69 | 9.70 | 176 | 135949 | 27276 | 63325621 |
Liquid product physical issue | 75.67 | 9.70 | 41 | 136084 | 1141 | 63351756 |
Left ventricle outflow tract obstruction | 74.90 | 9.70 | 27 | 136098 | 269 | 63352628 |
Discomfort | 74.74 | 9.70 | 154 | 135971 | 167220 | 63185677 |
Injection site ischaemia | 74.48 | 9.70 | 15 | 136110 | 3 | 63352894 |
Infusion site urticaria | 74.37 | 9.70 | 45 | 136080 | 1551 | 63351346 |
Anhedonia | 74.11 | 9.70 | 104 | 136021 | 10870 | 63342027 |
Needle issue | 74.07 | 9.70 | 101 | 136024 | 10275 | 63342622 |
Ventricular fibrillation | 73.60 | 9.70 | 108 | 136017 | 11759 | 63341138 |
Methaemoglobinaemia | 73.38 | 9.70 | 52 | 136073 | 2351 | 63350546 |
Cauda equina syndrome | 73.32 | 9.70 | 38 | 136087 | 964 | 63351933 |
Neutropenia | 72.38 | 9.70 | 168 | 135957 | 174837 | 63178060 |
Shock | 72.03 | 9.70 | 157 | 135968 | 23306 | 63329591 |
Swelling | 71.06 | 9.70 | 326 | 135799 | 275052 | 63077845 |
Administration site pain | 70.10 | 9.70 | 35 | 136090 | 819 | 63352078 |
Blister | 69.15 | 9.70 | 107 | 136018 | 129707 | 63223190 |
Renal injury | 69.09 | 9.70 | 93 | 136032 | 9346 | 63343551 |
Injury associated with device | 67.80 | 9.70 | 59 | 136066 | 3607 | 63349290 |
Stomatitis | 66.83 | 9.70 | 122 | 136003 | 138603 | 63214294 |
Electrocardiogram ST segment elevation | 66.26 | 9.70 | 60 | 136065 | 3867 | 63349030 |
C-reactive protein abnormal | 65.95 | 9.70 | 10 | 136115 | 46086 | 63306811 |
Tachycardia | 65.51 | 9.70 | 456 | 135669 | 117700 | 63235197 |
Body tinea | 65.10 | 9.70 | 44 | 136081 | 1841 | 63351056 |
Unevaluable event | 65.09 | 9.70 | 250 | 135875 | 51136 | 63301761 |
Expired product administered | 64.82 | 9.70 | 73 | 136052 | 6108 | 63346789 |
Infusion site irritation | 64.43 | 9.70 | 34 | 136091 | 896 | 63352001 |
Injection site pallor | 64.30 | 9.70 | 17 | 136108 | 50 | 63352847 |
Acute kidney injury | 63.78 | 9.70 | 319 | 135806 | 263096 | 63089801 |
Generalised tonic-clonic seizure | 63.15 | 9.70 | 170 | 135955 | 28846 | 63324051 |
Product use issue | 61.79 | 9.70 | 253 | 135872 | 220267 | 63132630 |
Dermatitis contact | 60.91 | 9.70 | 95 | 136030 | 10913 | 63341984 |
Pulse absent | 60.73 | 9.70 | 66 | 136059 | 5308 | 63347589 |
Lower respiratory tract infection | 60.53 | 9.70 | 120 | 136005 | 132187 | 63220710 |
COVID-19 immunisation | 60.02 | 9.70 | 41 | 136084 | 1746 | 63351151 |
Kidney infection | 60.01 | 9.70 | 145 | 135980 | 23031 | 63329866 |
Hyponatraemia | 59.82 | 9.70 | 92 | 136033 | 111808 | 63241089 |
Staphylococcal infection | 59.21 | 9.70 | 209 | 135916 | 41047 | 63311850 |
Anaesthetic complication neurological | 59.09 | 9.70 | 22 | 136103 | 242 | 63352655 |
Arteriospasm coronary | 58.04 | 9.70 | 56 | 136069 | 3912 | 63348985 |
Confusional state | 57.93 | 9.70 | 285 | 135840 | 236095 | 63116802 |
Airway peak pressure increased | 56.72 | 9.70 | 22 | 136103 | 273 | 63352624 |
Fungal infection | 56.58 | 9.70 | 191 | 135934 | 36683 | 63316214 |
Mobility decreased | 55.33 | 9.70 | 110 | 136015 | 121049 | 63231848 |
Eye infection | 55.31 | 9.70 | 96 | 136029 | 12049 | 63340848 |
Peripheral ischaemia | 55.28 | 9.70 | 60 | 136065 | 4818 | 63348079 |
Systemic toxicity | 54.88 | 9.70 | 16 | 136109 | 74 | 63352823 |
Post procedural complication | 54.42 | 9.70 | 116 | 136009 | 16958 | 63335939 |
Hypopyon | 54.25 | 9.70 | 28 | 136097 | 704 | 63352193 |
Blood cholesterol increased | 53.50 | 9.70 | 74 | 136051 | 93958 | 63258939 |
Blood pressure decreased | 53.36 | 9.70 | 278 | 135847 | 64744 | 63288153 |
Administration site erythema | 53.09 | 9.70 | 28 | 136097 | 737 | 63352160 |
Angioedema | 51.72 | 9.70 | 222 | 135903 | 47743 | 63305154 |
Gastroenteritis viral | 51.72 | 9.70 | 139 | 135986 | 23561 | 63329336 |
Type 2 diabetes mellitus | 51.56 | 9.70 | 37 | 136088 | 63831 | 63289066 |
Chills | 50.70 | 9.70 | 416 | 135709 | 112962 | 63239935 |
Electrocardiogram ST segment depression | 50.60 | 9.70 | 45 | 136080 | 2832 | 63350065 |
Infusion site discomfort | 50.53 | 9.70 | 34 | 136091 | 1412 | 63351485 |
Decreased appetite | 49.97 | 9.70 | 324 | 135801 | 250728 | 63102169 |
Sinus disorder | 49.61 | 9.70 | 140 | 135985 | 24413 | 63328484 |
Haemodynamic instability | 49.04 | 9.70 | 78 | 136047 | 9112 | 63343785 |
Inhibitory drug interaction | 48.99 | 9.70 | 44 | 136081 | 2805 | 63350092 |
Cataract operation complication | 47.92 | 9.70 | 16 | 136109 | 124 | 63352773 |
Tryptase increased | 47.90 | 9.70 | 21 | 136104 | 362 | 63352535 |
Extradural abscess | 47.78 | 9.70 | 28 | 136097 | 909 | 63351988 |
Peripheral swelling | 46.67 | 9.70 | 356 | 135769 | 265586 | 63087311 |
Poor venous access | 46.60 | 9.70 | 100 | 136025 | 14685 | 63338212 |
Seizure | 46.20 | 9.70 | 461 | 135664 | 132173 | 63220724 |
Disease progression | 45.95 | 9.70 | 124 | 136001 | 122634 | 63230263 |
Irritable bowel syndrome | 45.75 | 9.70 | 66 | 136059 | 82346 | 63270551 |
Vasoplegia syndrome | 45.59 | 9.70 | 34 | 136091 | 1665 | 63351232 |
Ventricular hypokinesia | 45.58 | 9.70 | 53 | 136072 | 4591 | 63348306 |
C-reactive protein increased | 44.97 | 9.70 | 84 | 136041 | 94623 | 63258274 |
Infection susceptibility increased | 44.69 | 9.70 | 46 | 136079 | 3475 | 63349422 |
Pharyngitis streptococcal | 44.29 | 9.70 | 81 | 136044 | 10591 | 63342306 |
Wrong product administered | 44.17 | 9.70 | 60 | 136065 | 6081 | 63346816 |
Anaemia | 43.76 | 9.70 | 410 | 135715 | 293020 | 63059877 |
Immunisation reaction | 43.55 | 9.70 | 23 | 136102 | 607 | 63352290 |
Skin infection | 43.36 | 9.70 | 98 | 136027 | 14904 | 63337993 |
Intentional self-injury | 43.35 | 9.70 | 3 | 136122 | 25684 | 63327213 |
Swollen tongue | 43.00 | 9.70 | 168 | 135957 | 34632 | 63318265 |
Cystitis | 42.98 | 9.70 | 232 | 135893 | 54759 | 63298138 |
Myocardial ischaemia | 42.88 | 9.70 | 89 | 136036 | 12770 | 63340127 |
Emotional distress | 42.57 | 9.70 | 160 | 135965 | 32389 | 63320508 |
Infusion site reaction | 42.20 | 9.70 | 45 | 136080 | 3542 | 63349355 |
Procedural hypotension | 41.63 | 9.70 | 28 | 136097 | 1162 | 63351735 |
Malignant neoplasm progression | 41.55 | 9.70 | 70 | 136055 | 82051 | 63270846 |
Accidental overdose | 41.44 | 9.70 | 127 | 135998 | 23182 | 63329715 |
Purtscher retinopathy | 40.84 | 9.70 | 13 | 136112 | 85 | 63352812 |
Blood creatinine increased | 40.75 | 9.70 | 79 | 136046 | 87765 | 63265132 |
Stress | 40.06 | 9.70 | 264 | 135861 | 66903 | 63285994 |
Pancytopenia | 39.30 | 9.70 | 94 | 136031 | 96839 | 63256058 |
Sinus tachycardia | 39.28 | 9.70 | 128 | 135997 | 24140 | 63328757 |
Chest discomfort | 39.15 | 9.70 | 384 | 135741 | 109585 | 63243312 |
Prescribed underdose | 39.07 | 9.70 | 8 | 136117 | 29681 | 63323216 |
Pharyngeal oedema | 38.96 | 9.70 | 89 | 136036 | 13632 | 63339265 |
Lip swelling | 38.41 | 9.70 | 150 | 135975 | 30913 | 63321984 |
Status asthmaticus | 38.33 | 9.70 | 24 | 136101 | 880 | 63352017 |
Thrombocytopenia | 38.32 | 9.70 | 180 | 135945 | 150977 | 63201920 |
Dermatitis atopic | 38.09 | 9.70 | 72 | 136053 | 9652 | 63343245 |
Hip arthroplasty | 37.94 | 9.70 | 28 | 136097 | 47618 | 63305279 |
Procedural complication | 37.41 | 9.70 | 52 | 136073 | 5387 | 63347510 |
Drug ineffective for unapproved indication | 36.99 | 9.70 | 158 | 135967 | 33905 | 63318992 |
Influenza | 36.94 | 9.70 | 376 | 135749 | 108346 | 63244551 |
Viral infection | 36.87 | 9.70 | 163 | 135962 | 35500 | 63317397 |
Pulmonary oedema | 36.65 | 9.70 | 222 | 135903 | 54651 | 63298246 |
Extradural haematoma | 36.55 | 9.70 | 30 | 136095 | 1692 | 63351205 |
Hypoaesthesia oral | 36.41 | 9.70 | 84 | 136041 | 12949 | 63339948 |
Hyperaesthesia | 36.30 | 9.70 | 69 | 136056 | 9289 | 63343608 |
Vitritis | 36.29 | 9.70 | 24 | 136101 | 968 | 63351929 |
Circulatory collapse | 35.76 | 9.70 | 116 | 136009 | 21822 | 63331075 |
Asthenia | 35.69 | 9.70 | 593 | 135532 | 383011 | 62969886 |
Drug reaction with eosinophilia and systemic symptoms | 35.53 | 9.70 | 14 | 136111 | 33822 | 63319075 |
Infusion site warmth | 35.12 | 9.70 | 30 | 136095 | 1788 | 63351109 |
Condition aggravated | 35.09 | 9.70 | 629 | 135496 | 401588 | 62951309 |
Tooth infection | 35.05 | 9.70 | 101 | 136024 | 17819 | 63335078 |
Limb injury | 34.79 | 9.70 | 127 | 135998 | 25350 | 63327547 |
Throat tightness | 34.79 | 9.70 | 125 | 136000 | 24762 | 63328135 |
Administration site pruritus | 34.65 | 9.70 | 16 | 136109 | 313 | 63352584 |
Mydriasis | 34.44 | 9.70 | 78 | 136047 | 11878 | 63341019 |
Paraplegia | 34.08 | 9.70 | 35 | 136090 | 2637 | 63350260 |
Glucose tolerance impaired | 33.97 | 9.70 | 55 | 136070 | 6522 | 63346375 |
Pharyngeal swelling | 33.68 | 9.70 | 54 | 136071 | 6350 | 63346547 |
Administration site bruise | 33.62 | 9.70 | 17 | 136108 | 409 | 63352488 |
Abortion spontaneous | 33.53 | 9.70 | 31 | 136094 | 47164 | 63305733 |
Death | 33.44 | 9.70 | 583 | 135542 | 373798 | 62979099 |
Liver function test abnormal | 32.66 | 9.70 | 33 | 136092 | 48148 | 63304749 |
Laryngeal oedema | 32.55 | 9.70 | 50 | 136075 | 5668 | 63347229 |
Anaphylactoid reaction | 32.45 | 9.70 | 40 | 136085 | 3683 | 63349214 |
Platelet aggregation inhibition | 32.40 | 9.70 | 12 | 136113 | 130 | 63352767 |
Abdominal pain upper | 32.25 | 9.70 | 285 | 135840 | 206159 | 63146738 |
Inability to afford medication | 32.23 | 9.70 | 32 | 136093 | 2315 | 63350582 |
Nerve root injury | 32.12 | 9.70 | 9 | 136116 | 35 | 63352862 |
Administration site reaction | 31.95 | 9.70 | 14 | 136111 | 241 | 63352656 |
Troponin I increased | 31.64 | 9.70 | 31 | 136094 | 2207 | 63350690 |
Injection site injury | 31.61 | 9.70 | 19 | 136106 | 647 | 63352250 |
Unresponsive to stimuli | 31.58 | 9.70 | 150 | 135975 | 33666 | 63319231 |
Type I hypersensitivity | 31.29 | 9.70 | 35 | 136090 | 2907 | 63349990 |
Cholestasis | 31.20 | 9.70 | 12 | 136113 | 29422 | 63323475 |
Adverse event | 31.12 | 9.70 | 61 | 136064 | 67498 | 63285399 |
Embolia cutis medicamentosa | 30.69 | 9.70 | 16 | 136109 | 411 | 63352486 |
Product contamination microbial | 30.64 | 9.70 | 13 | 136112 | 206 | 63352691 |
Leukopenia | 30.50 | 9.70 | 76 | 136049 | 77214 | 63275683 |
Musculoskeletal pain | 30.34 | 9.70 | 99 | 136026 | 92178 | 63260719 |
Loss of personal independence in daily activities | 30.20 | 9.70 | 107 | 136018 | 97183 | 63255714 |
Ophthalmoplegia | 30.02 | 9.70 | 25 | 136100 | 1439 | 63351458 |
Liver disorder | 29.79 | 9.70 | 43 | 136082 | 53644 | 63299253 |
Uterine hypertonus | 29.77 | 9.70 | 14 | 136111 | 286 | 63352611 |
Anterior chamber cell | 29.72 | 9.70 | 17 | 136108 | 527 | 63352370 |
Drug abuse | 29.65 | 9.70 | 70 | 136055 | 72448 | 63280449 |
Pneumocephalus | 29.63 | 9.70 | 12 | 136113 | 168 | 63352729 |
Infusion site discolouration | 29.59 | 9.70 | 20 | 136105 | 837 | 63352060 |
Infusion site induration | 29.58 | 9.70 | 23 | 136102 | 1199 | 63351698 |
Ill-defined disorder | 29.53 | 9.70 | 84 | 136041 | 81671 | 63271226 |
Knee arthroplasty | 29.50 | 9.70 | 44 | 136081 | 54162 | 63298735 |
Poor quality sleep | 29.47 | 9.70 | 102 | 136023 | 19833 | 63333064 |
Injection site coldness | 28.84 | 9.70 | 10 | 136115 | 88 | 63352809 |
Phrenic nerve paralysis | 28.64 | 9.70 | 12 | 136113 | 184 | 63352713 |
Drug resistance | 28.53 | 9.70 | 7 | 136118 | 22926 | 63329971 |
White blood cell count decreased | 28.43 | 9.70 | 178 | 135947 | 138926 | 63213971 |
Injection site hypoaesthesia | 28.41 | 9.70 | 16 | 136109 | 481 | 63352416 |
Anxiety | 28.38 | 9.70 | 638 | 135487 | 216903 | 63135994 |
Inflammation | 27.93 | 9.70 | 87 | 136038 | 82186 | 63270711 |
Paralysis | 27.87 | 9.70 | 64 | 136061 | 9836 | 63343061 |
Red blood cell sedimentation rate increased | 27.73 | 9.70 | 32 | 136093 | 43950 | 63308947 |
Administration site extravasation | 27.44 | 9.70 | 20 | 136105 | 945 | 63351952 |
PO2 decreased | 27.37 | 9.70 | 24 | 136101 | 1482 | 63351415 |
Foetal exposure during delivery | 27.23 | 9.70 | 11 | 136114 | 153 | 63352744 |
Aqueous fibrin | 27.15 | 9.70 | 9 | 136116 | 68 | 63352829 |
Neuromuscular block prolonged | 27.12 | 9.70 | 16 | 136109 | 526 | 63352371 |
Bladder prolapse | 27.06 | 9.70 | 28 | 136097 | 2128 | 63350769 |
Removal of foreign body | 26.93 | 9.70 | 8 | 136117 | 40 | 63352857 |
Vasospasm | 26.83 | 9.70 | 18 | 136107 | 744 | 63352153 |
Oral herpes | 26.82 | 9.70 | 119 | 136006 | 25955 | 63326942 |
Psoriasis | 26.75 | 9.70 | 96 | 136029 | 86861 | 63266036 |
Blood pressure increased | 26.66 | 9.70 | 492 | 135633 | 161570 | 63191327 |
Device infusion issue | 26.54 | 9.70 | 27 | 136098 | 2011 | 63350886 |
Fear of eating | 26.22 | 9.70 | 14 | 136111 | 378 | 63352519 |
Blood pH decreased | 26.19 | 9.70 | 30 | 136095 | 2557 | 63350340 |
Influenza like illness | 26.09 | 9.70 | 238 | 135887 | 66586 | 63286311 |
Therapeutic product effect incomplete | 26.09 | 9.70 | 159 | 135966 | 124897 | 63228000 |
Gas gangrene | 25.93 | 9.70 | 10 | 136115 | 122 | 63352775 |
Bursitis infective | 25.62 | 9.70 | 22 | 136103 | 1321 | 63351576 |
Hepatotoxicity | 25.53 | 9.70 | 25 | 136100 | 37016 | 63315881 |
Orthostatic hypotension | 25.40 | 9.70 | 24 | 136101 | 36136 | 63316761 |
Anaphylactoid shock | 25.29 | 9.70 | 13 | 136112 | 324 | 63352573 |
Abdominal pain | 25.22 | 9.70 | 460 | 135665 | 292996 | 63059901 |
Osteonecrosis of jaw | 25.04 | 9.70 | 23 | 136102 | 35100 | 63317797 |
Apnoea | 24.99 | 9.70 | 54 | 136071 | 7968 | 63344929 |
Corneal epithelium defect | 24.76 | 9.70 | 13 | 136112 | 339 | 63352558 |
Normal newborn | 24.68 | 9.70 | 55 | 136070 | 8286 | 63344611 |
Product distribution issue | 24.61 | 9.70 | 22 | 136103 | 1394 | 63351503 |
Cyanosis | 24.47 | 9.70 | 86 | 136039 | 16849 | 63336048 |
Meningitis aseptic | 24.46 | 9.70 | 40 | 136085 | 4783 | 63348114 |
Peripheral nerve injury | 24.39 | 9.70 | 14 | 136111 | 437 | 63352460 |
Spinal stroke | 24.08 | 9.70 | 7 | 136118 | 32 | 63352865 |
Cardiac failure congestive | 24.05 | 9.70 | 109 | 136016 | 92324 | 63260573 |
Food allergy | 24.01 | 9.70 | 66 | 136059 | 11335 | 63341562 |
Axillary nerve injury | 24.00 | 9.70 | 6 | 136119 | 13 | 63352884 |
Tracheal deviation | 23.95 | 9.70 | 10 | 136115 | 152 | 63352745 |
Meningitis chemical | 23.83 | 9.70 | 10 | 136115 | 154 | 63352743 |
Product adhesion issue | 23.74 | 9.70 | 39 | 136086 | 4680 | 63348217 |
Eyelid rash | 23.71 | 9.70 | 10 | 136115 | 156 | 63352741 |
Device expulsion | 23.58 | 9.70 | 24 | 136101 | 34898 | 63317999 |
Upper airway obstruction | 23.31 | 9.70 | 16 | 136109 | 687 | 63352210 |
Metabolic acidosis | 23.25 | 9.70 | 171 | 135954 | 44898 | 63307999 |
Mast cell activation syndrome | 23.24 | 9.70 | 17 | 136108 | 808 | 63352089 |
Ventricular extrasystoles | 22.98 | 9.70 | 66 | 136059 | 11621 | 63341276 |
Pulmonary fibrosis | 22.97 | 9.70 | 31 | 136094 | 39778 | 63313119 |
Inappropriate antidiuretic hormone secretion | 22.95 | 9.70 | 3 | 136122 | 15459 | 63337438 |
Impaired work ability | 22.93 | 9.70 | 86 | 136039 | 17389 | 63335508 |
Parophthalmia | 22.92 | 9.70 | 12 | 136113 | 311 | 63352586 |
Sinus operation | 22.89 | 9.70 | 28 | 136097 | 2558 | 63350339 |
Respiratory depression | 22.79 | 9.70 | 73 | 136052 | 13642 | 63339255 |
Spinal operation | 22.76 | 9.70 | 53 | 136072 | 8218 | 63344679 |
Eye inflammation | 22.61 | 9.70 | 42 | 136083 | 5557 | 63347340 |
Neonatal toxicity | 22.60 | 9.70 | 6 | 136119 | 18 | 63352879 |
Infusion site scar | 22.44 | 9.70 | 14 | 136111 | 510 | 63352387 |
Drug tolerance decreased | 22.40 | 9.70 | 5 | 136120 | 17468 | 63335429 |
Creatinine renal clearance decreased | 22.30 | 9.70 | 4 | 136121 | 16304 | 63336593 |
Myopathy toxic | 22.29 | 9.70 | 14 | 136111 | 516 | 63352381 |
Interstitial lung disease | 22.07 | 9.70 | 64 | 136061 | 61844 | 63291053 |
Gastrointestinal disorder | 21.91 | 9.70 | 178 | 135947 | 131061 | 63221836 |
Cranial nerve palsies multiple | 21.90 | 9.70 | 6 | 136119 | 21 | 63352876 |
Respiratory acidosis | 21.83 | 9.70 | 46 | 136079 | 6669 | 63346228 |
Respiratory distress | 21.81 | 9.70 | 136 | 135989 | 33815 | 63319082 |
Rectal prolapse | 21.79 | 9.70 | 24 | 136101 | 1959 | 63350938 |
Retinal artery occlusion | 21.71 | 9.70 | 22 | 136103 | 1631 | 63351266 |
Trigemino-cardiac reflex | 21.70 | 9.70 | 7 | 136118 | 48 | 63352849 |
Constipation | 21.45 | 9.70 | 346 | 135779 | 224597 | 63128300 |
Bundle branch block left | 21.40 | 9.70 | 47 | 136078 | 7012 | 63345885 |
Rash | 21.36 | 9.70 | 984 | 135141 | 559887 | 62793010 |
Loss of consciousness | 21.34 | 9.70 | 364 | 135761 | 117757 | 63235140 |
Hypopnoea | 21.27 | 9.70 | 33 | 136092 | 3773 | 63349124 |
Animal bite | 21.24 | 9.70 | 29 | 136096 | 2953 | 63349944 |
Septic arthritis staphylococcal | 21.18 | 9.70 | 13 | 136112 | 460 | 63352437 |
Ventricular arrhythmia | 21.13 | 9.70 | 33 | 136092 | 3795 | 63349102 |
Catarrh | 21.05 | 9.70 | 21 | 136104 | 1528 | 63351369 |
PCO2 increased | 21.04 | 9.70 | 19 | 136106 | 1220 | 63351677 |
Jaundice | 21.03 | 9.70 | 19 | 136106 | 29232 | 63323665 |
Bone erosion | 20.92 | 9.70 | 6 | 136119 | 17711 | 63335186 |
Vitamin D increased | 20.80 | 9.70 | 15 | 136110 | 697 | 63352200 |
Retinal vasculitis | 20.74 | 9.70 | 17 | 136108 | 957 | 63351940 |
Hepatocellular injury | 20.64 | 9.70 | 17 | 136108 | 27364 | 63325533 |
Eyelid ptosis | 20.48 | 9.70 | 47 | 136078 | 7220 | 63345677 |
Arterial spasm | 20.45 | 9.70 | 7 | 136118 | 59 | 63352838 |
Spinal epidural haemorrhage | 20.43 | 9.70 | 8 | 136117 | 102 | 63352795 |
Administration site haemorrhage | 20.29 | 9.70 | 8 | 136117 | 104 | 63352793 |
Injection site discharge | 20.19 | 9.70 | 16 | 136109 | 858 | 63352039 |
Gait inability | 20.18 | 9.70 | 53 | 136072 | 52906 | 63299991 |
Cellulitis | 20.03 | 9.70 | 266 | 135859 | 81692 | 63271205 |
Anal skin tags | 19.98 | 9.70 | 13 | 136112 | 510 | 63352387 |
Injection site pain | 19.95 | 9.70 | 390 | 135735 | 129410 | 63223487 |
Postresuscitation encephalopathy | 19.94 | 9.70 | 5 | 136120 | 11 | 63352886 |
Vaccination complication | 19.89 | 9.70 | 18 | 136107 | 1159 | 63351738 |
Catheter site pain | 19.73 | 9.70 | 36 | 136089 | 4699 | 63348198 |
Fear of death | 19.66 | 9.70 | 17 | 136108 | 1030 | 63351867 |
Injection site inflammation | 19.66 | 9.70 | 32 | 136093 | 3811 | 63349086 |
Device ineffective | 19.65 | 9.70 | 10 | 136115 | 244 | 63352653 |
No adverse event | 19.62 | 9.70 | 154 | 135971 | 41251 | 63311646 |
Oedema peripheral | 19.60 | 9.70 | 287 | 135838 | 189224 | 63163673 |
Alanine aminotransferase increased | 19.58 | 9.70 | 136 | 135989 | 103634 | 63249263 |
Product availability issue | 19.32 | 9.70 | 33 | 136092 | 4088 | 63348809 |
Bacterial infection | 19.31 | 9.70 | 88 | 136037 | 19411 | 63333486 |
Status epilepticus | 19.19 | 9.70 | 74 | 136051 | 15159 | 63337738 |
Administration site nodule | 19.15 | 9.70 | 6 | 136119 | 37 | 63352860 |
Blood lactic acid increased | 19.06 | 9.70 | 45 | 136080 | 7041 | 63345856 |
Administration site irritation | 19.01 | 9.70 | 6 | 136119 | 38 | 63352859 |
Troponin T increased | 18.91 | 9.70 | 18 | 136107 | 1236 | 63351661 |
Steroid dependence | 18.78 | 9.70 | 21 | 136104 | 1743 | 63351154 |
Heart rate increased | 18.73 | 9.70 | 295 | 135830 | 93943 | 63258954 |
Lip dry | 18.71 | 9.70 | 5 | 136120 | 15465 | 63337432 |
Metastases to liver | 18.68 | 9.70 | 14 | 136111 | 23625 | 63329272 |
Obesity | 18.66 | 9.70 | 22 | 136103 | 29930 | 63322967 |
Gastrointestinal haemorrhage | 18.65 | 9.70 | 100 | 136025 | 81076 | 63271821 |
Local reaction | 18.60 | 9.70 | 14 | 136111 | 695 | 63352202 |
Muscle tightness | 18.57 | 9.70 | 62 | 136063 | 11838 | 63341059 |
Extremity necrosis | 18.56 | 9.70 | 20 | 136105 | 1593 | 63351304 |
Electrocardiogram QRS complex prolonged | 18.53 | 9.70 | 40 | 136085 | 5898 | 63346999 |
Hypercalcaemia | 18.52 | 9.70 | 20 | 136105 | 28302 | 63324595 |
Spinal anaesthesia | 18.50 | 9.70 | 6 | 136119 | 42 | 63352855 |
Harlequin syndrome | 18.50 | 9.70 | 6 | 136119 | 42 | 63352855 |
Burns second degree | 18.46 | 9.70 | 22 | 136103 | 1956 | 63350941 |
Lung hyperinflation | 18.42 | 9.70 | 18 | 136107 | 1277 | 63351620 |
Nystagmus | 18.39 | 9.70 | 41 | 136084 | 6179 | 63346718 |
Atonic urinary bladder | 18.33 | 9.70 | 7 | 136118 | 83 | 63352814 |
Pneumonia | 18.32 | 9.70 | 1174 | 134951 | 455593 | 62897304 |
Nasopharyngitis | 18.29 | 9.70 | 692 | 135433 | 253565 | 63099332 |
Platelet count decreased | 18.26 | 9.70 | 160 | 135965 | 115962 | 63236935 |
Scar | 18.23 | 9.70 | 68 | 136057 | 13714 | 63339183 |
Off label use | 18.19 | 9.70 | 1224 | 134901 | 673238 | 62679659 |
Apnoeic attack | 18.18 | 9.70 | 10 | 136115 | 287 | 63352610 |
International normalised ratio increased | 18.04 | 9.70 | 46 | 136079 | 46379 | 63306518 |
Electrocardiogram T wave inversion | 17.83 | 9.70 | 29 | 136096 | 3452 | 63349445 |
Product use in unapproved indication | 17.67 | 9.70 | 506 | 135619 | 178574 | 63174323 |
Post procedural infection | 17.64 | 9.70 | 52 | 136073 | 9290 | 63343607 |
Nasal discharge discolouration | 17.58 | 9.70 | 23 | 136102 | 2248 | 63350649 |
Administration site discolouration | 17.49 | 9.70 | 6 | 136119 | 51 | 63352846 |
Nerve block | 17.39 | 9.70 | 14 | 136111 | 768 | 63352129 |
Multiple organ dysfunction syndrome | 17.27 | 9.70 | 192 | 135933 | 56560 | 63296337 |
Mean arterial pressure decreased | 17.17 | 9.70 | 8 | 136117 | 160 | 63352737 |
Drug-induced liver injury | 17.11 | 9.70 | 38 | 136087 | 40184 | 63312713 |
Brain injury | 17.10 | 9.70 | 43 | 136082 | 7000 | 63345897 |
Neurogenic shock | 17.08 | 9.70 | 10 | 136115 | 324 | 63352573 |
Disease recurrence | 17.02 | 9.70 | 21 | 136104 | 28009 | 63324888 |
Enzyme induction | 16.99 | 9.70 | 6 | 136119 | 56 | 63352841 |
Product contamination physical | 16.91 | 9.70 | 7 | 136118 | 104 | 63352793 |
Gastrointestinal infection | 16.90 | 9.70 | 51 | 136074 | 9230 | 63343667 |
Gait disturbance | 16.72 | 9.70 | 284 | 135841 | 182894 | 63170003 |
Product measured potency issue | 16.67 | 9.70 | 7 | 136118 | 108 | 63352789 |
Systolic anterior motion of mitral valve | 16.67 | 9.70 | 5 | 136120 | 26 | 63352871 |
Arthropod bite | 16.61 | 9.70 | 46 | 136079 | 7932 | 63344965 |
Hepatitis | 16.59 | 9.70 | 38 | 136087 | 39750 | 63313147 |
Transaminases increased | 16.55 | 9.70 | 26 | 136099 | 31341 | 63321556 |
Conjunctival oedema | 16.53 | 9.70 | 13 | 136112 | 689 | 63352208 |
Osteoarthritis | 16.52 | 9.70 | 128 | 135997 | 95215 | 63257682 |
Femur fracture | 16.52 | 9.70 | 41 | 136084 | 41715 | 63311182 |
Dental restoration failure | 16.49 | 9.70 | 15 | 136110 | 972 | 63351925 |
Spinal cord infarction | 16.46 | 9.70 | 9 | 136116 | 255 | 63352642 |
Therapeutic product effect prolonged | 16.41 | 9.70 | 10 | 136115 | 349 | 63352548 |
Infusion site oedema | 16.38 | 9.70 | 14 | 136111 | 835 | 63352062 |
Reversible cerebral vasoconstriction syndrome | 16.21 | 9.70 | 24 | 136101 | 2634 | 63350263 |
Vasoconstriction | 16.16 | 9.70 | 12 | 136113 | 584 | 63352313 |
Hypocalcaemia | 16.06 | 9.70 | 27 | 136098 | 31686 | 63321211 |
ECG signs of myocardial ischaemia | 15.96 | 9.70 | 6 | 136119 | 68 | 63352829 |
Oropharyngeal discomfort | 15.92 | 9.70 | 35 | 136090 | 5225 | 63347672 |
Accidental exposure to product by child | 15.89 | 9.70 | 16 | 136109 | 1177 | 63351720 |
Ischaemia | 15.88 | 9.70 | 33 | 136092 | 4739 | 63348158 |
Joint stiffness | 15.88 | 9.70 | 42 | 136083 | 41827 | 63311070 |
Streptococcal infection | 15.84 | 9.70 | 37 | 136088 | 5750 | 63347147 |
Rhinitis | 15.81 | 9.70 | 57 | 136068 | 11309 | 63341588 |
Punctate keratitis | 15.72 | 9.70 | 12 | 136113 | 609 | 63352288 |
Product contamination | 15.63 | 9.70 | 13 | 136112 | 747 | 63352150 |
Injury | 15.59 | 9.70 | 232 | 135893 | 73015 | 63279882 |
Depressed mood | 15.48 | 9.70 | 40 | 136085 | 40151 | 63312746 |
Grip strength decreased | 15.41 | 9.70 | 15 | 136110 | 22272 | 63330625 |
Vitamin B1 decreased | 15.40 | 9.70 | 8 | 136117 | 204 | 63352693 |
Neutropenic sepsis | 15.38 | 9.70 | 8 | 136117 | 16430 | 63336467 |
Glossoptosis | 15.36 | 9.70 | 6 | 136119 | 76 | 63352821 |
Pneumonia mycoplasmal | 15.34 | 9.70 | 14 | 136111 | 911 | 63351986 |
Supraventricular tachycardia | 15.34 | 9.70 | 66 | 136059 | 14205 | 63338692 |
Systolic dysfunction | 15.28 | 9.70 | 18 | 136107 | 1581 | 63351316 |
Central venous catheterisation | 15.18 | 9.70 | 23 | 136102 | 2576 | 63350321 |
Gastric infection | 15.15 | 9.70 | 27 | 136098 | 3460 | 63349437 |
Device issue | 15.11 | 9.70 | 95 | 136030 | 23686 | 63329211 |
Blood bilirubin increased | 15.06 | 9.70 | 36 | 136089 | 37104 | 63315793 |
Neoplasm progression | 15.02 | 9.70 | 35 | 136090 | 36393 | 63316504 |
Cognitive disorder | 15.01 | 9.70 | 65 | 136060 | 55750 | 63297147 |
Urticaria chronic | 14.99 | 9.70 | 12 | 136113 | 653 | 63352244 |
Eosinophilia | 14.96 | 9.70 | 16 | 136109 | 22740 | 63330157 |
Mania | 14.95 | 9.70 | 4 | 136121 | 12363 | 63340534 |
Postural orthostatic tachycardia syndrome | 14.86 | 9.70 | 16 | 136109 | 1273 | 63351624 |
Blood calcium decreased | 14.85 | 9.70 | 21 | 136104 | 26430 | 63326467 |
Eye infarction | 14.84 | 9.70 | 5 | 136120 | 40 | 63352857 |
Sensory loss | 14.80 | 9.70 | 52 | 136073 | 10186 | 63342711 |
Balance disorder | 14.78 | 9.70 | 113 | 136012 | 84309 | 63268588 |
Infected bite | 14.76 | 9.70 | 20 | 136105 | 2022 | 63350875 |
Cold sweat | 14.75 | 9.70 | 58 | 136067 | 11989 | 63340908 |
Vocal cord dysfunction | 14.62 | 9.70 | 11 | 136114 | 546 | 63352351 |
Propofol infusion syndrome | 14.62 | 9.70 | 14 | 136111 | 969 | 63351928 |
Meningitis | 14.57 | 9.70 | 41 | 136084 | 7136 | 63345761 |
Hepatic cirrhosis | 14.53 | 9.70 | 19 | 136106 | 24715 | 63328182 |
Maternal exposure during pregnancy | 14.49 | 9.70 | 360 | 135765 | 219702 | 63133195 |
Anion gap increased | 14.48 | 9.70 | 19 | 136106 | 1863 | 63351034 |
Therapy interrupted | 14.45 | 9.70 | 119 | 136006 | 32336 | 63320561 |
Oral pruritus | 14.42 | 9.70 | 21 | 136104 | 2270 | 63350627 |
Neuroleptic malignant syndrome | 14.39 | 9.70 | 4 | 136121 | 12052 | 63340845 |
Sleep disorder | 14.37 | 9.70 | 109 | 136016 | 81457 | 63271440 |
Arachnoiditis | 14.30 | 9.70 | 9 | 136116 | 333 | 63352564 |
Arthritis bacterial | 14.19 | 9.70 | 38 | 136087 | 6425 | 63346472 |
Rotator cuff syndrome | 14.17 | 9.70 | 62 | 136063 | 13440 | 63339457 |
Administration site scar | 14.13 | 9.70 | 5 | 136120 | 47 | 63352850 |
Mastocytosis | 14.12 | 9.70 | 11 | 136114 | 575 | 63352322 |
Localised infection | 14.11 | 9.70 | 112 | 136013 | 30098 | 63322799 |
Hypomagnesaemia | 14.07 | 9.70 | 25 | 136100 | 28712 | 63324185 |
Sedation complication | 14.05 | 9.70 | 6 | 136119 | 13816 | 63339081 |
Macular degeneration | 14.04 | 9.70 | 19 | 136106 | 24357 | 63328540 |
Epidural analgesia | 14.04 | 9.70 | 5 | 136120 | 48 | 63352849 |
Smoke sensitivity | 14.03 | 9.70 | 10 | 136115 | 456 | 63352441 |
Postpartum disorder | 13.99 | 9.70 | 4 | 136121 | 17 | 63352880 |
Gastrointestinal bacterial overgrowth | 13.95 | 9.70 | 13 | 136112 | 869 | 63352028 |
Distributive shock | 13.94 | 9.70 | 16 | 136109 | 1367 | 63351530 |
Oropharyngeal pain | 13.88 | 9.70 | 282 | 135843 | 94205 | 63258692 |
Rhabdomyolysis | 13.86 | 9.70 | 48 | 136077 | 43903 | 63308994 |
Cardiac assistance device user | 13.77 | 9.70 | 5 | 136120 | 51 | 63352846 |
Peritonitis | 13.76 | 9.70 | 10 | 136115 | 17144 | 63335753 |
Cough | 13.71 | 9.70 | 763 | 135362 | 291980 | 63060917 |
Allergic reaction to excipient | 13.59 | 9.70 | 9 | 136116 | 364 | 63352533 |
Paraesthesia oral | 13.56 | 9.70 | 79 | 136046 | 19177 | 63333720 |
Injection site haemorrhage | 13.55 | 9.70 | 94 | 136031 | 24220 | 63328677 |
Pupil fixed | 13.51 | 9.70 | 18 | 136107 | 1791 | 63351106 |
SARS-CoV-2 test positive | 13.49 | 9.70 | 43 | 136082 | 8013 | 63344884 |
Incision site rash | 13.47 | 9.70 | 4 | 136121 | 20 | 63352877 |
Trigeminal palsy | 13.47 | 9.70 | 4 | 136121 | 20 | 63352877 |
Delayed recovery from anaesthesia | 13.44 | 9.70 | 12 | 136113 | 759 | 63352138 |
Concussion | 13.41 | 9.70 | 47 | 136078 | 9197 | 63343700 |
Procedural anxiety | 13.37 | 9.70 | 12 | 136113 | 764 | 63352133 |
Nerve root injury cervical | 13.37 | 9.70 | 3 | 136122 | 3 | 63352894 |
SARS-CoV-2 test false positive | 13.37 | 9.70 | 3 | 136122 | 3 | 63352894 |
Quadriparesis | 13.36 | 9.70 | 19 | 136106 | 2010 | 63350887 |
Obstruction | 13.31 | 9.70 | 24 | 136101 | 3103 | 63349794 |
Caffeine allergy | 13.30 | 9.70 | 4 | 136121 | 21 | 63352876 |
Vaccination site rash | 13.30 | 9.70 | 4 | 136121 | 21 | 63352876 |
Ehlers-Danlos syndrome | 13.25 | 9.70 | 7 | 136118 | 185 | 63352712 |
COVID-19 pneumonia | 13.24 | 9.70 | 63 | 136062 | 14146 | 63338751 |
Nephrolithiasis | 13.21 | 9.70 | 143 | 135982 | 41841 | 63311056 |
Myocardial necrosis marker increased | 13.15 | 9.70 | 18 | 136107 | 1838 | 63351059 |
Gastroenteritis | 13.14 | 9.70 | 23 | 136102 | 26567 | 63326330 |
Diplegia | 13.12 | 9.70 | 14 | 136111 | 1103 | 63351794 |
Malabsorption from administration site | 13.06 | 9.70 | 6 | 136119 | 116 | 63352781 |
Corneal abrasion | 13.04 | 9.70 | 14 | 136111 | 1110 | 63351787 |
Accelerated idioventricular rhythm | 13.04 | 9.70 | 5 | 136120 | 60 | 63352837 |
Spinal epidural haematoma | 13.01 | 9.70 | 14 | 136111 | 1113 | 63351784 |
Forced vital capacity abnormal | 13 | 9.70 | 4 | 136121 | 23 | 63352874 |
Pancreatitis acute | 12.97 | 9.70 | 24 | 136101 | 27142 | 63325755 |
Psychotic disorder | 12.92 | 9.70 | 22 | 136103 | 25690 | 63327207 |
Adjustment disorder with depressed mood | 12.92 | 9.70 | 3 | 136122 | 10201 | 63342696 |
Paranasal cyst | 12.87 | 9.70 | 9 | 136116 | 398 | 63352499 |
Injection site extravasation | 12.86 | 9.70 | 45 | 136080 | 8796 | 63344101 |
Lyme disease | 12.85 | 9.70 | 25 | 136100 | 3424 | 63349473 |
Drainage | 12.85 | 9.70 | 7 | 136118 | 197 | 63352700 |
Nail bed tenderness | 12.83 | 9.70 | 9 | 136116 | 400 | 63352497 |
Dry mouth | 12.81 | 9.70 | 106 | 136019 | 77757 | 63275140 |
Facet joint syndrome | 12.78 | 9.70 | 5 | 136120 | 12133 | 63340764 |
Chondromalacia | 12.76 | 9.70 | 8 | 136117 | 294 | 63352603 |
Tongue pruritus | 12.75 | 9.70 | 10 | 136115 | 528 | 63352369 |
Rubber sensitivity | 12.73 | 9.70 | 20 | 136105 | 2311 | 63350586 |
Thermal burn | 12.73 | 9.70 | 35 | 136090 | 6011 | 63346886 |
Post-anoxic myoclonus | 12.72 | 9.70 | 4 | 136121 | 25 | 63352872 |
Urticarial vasculitis | 12.70 | 9.70 | 11 | 136114 | 668 | 63352229 |
Infusion site vesicles | 12.70 | 9.70 | 10 | 136115 | 531 | 63352366 |
Autonomic neuropathy | 12.69 | 9.70 | 14 | 136111 | 1145 | 63351752 |
Lung neoplasm malignant | 12.69 | 9.70 | 14 | 136111 | 19619 | 63333278 |
Throat irritation | 12.68 | 9.70 | 130 | 135995 | 37517 | 63315380 |
Administration site rash | 12.68 | 9.70 | 5 | 136120 | 65 | 63352832 |
Laryngeal obstruction | 12.65 | 9.70 | 6 | 136119 | 125 | 63352772 |
Coronary artery disease | 12.64 | 9.70 | 32 | 136093 | 32345 | 63320552 |
Aspartate aminotransferase increased | 12.64 | 9.70 | 128 | 135997 | 90149 | 63262748 |
Respiratory tract oedema | 12.64 | 9.70 | 10 | 136115 | 535 | 63352362 |
Hyperthermia malignant | 12.63 | 9.70 | 12 | 136113 | 822 | 63352075 |
Hallucination, tactile | 12.59 | 9.70 | 8 | 136117 | 301 | 63352596 |
Purpura | 12.50 | 9.70 | 53 | 136072 | 11332 | 63341565 |
Metastases to bone | 12.50 | 9.70 | 16 | 136109 | 21003 | 63331894 |
Haemoglobin decreased | 12.49 | 9.70 | 228 | 135897 | 145257 | 63207640 |
Airway complication of anaesthesia | 12.47 | 9.70 | 7 | 136118 | 209 | 63352688 |
Blood glucose increased | 12.47 | 9.70 | 117 | 136008 | 83639 | 63269258 |
Heart rate decreased | 12.46 | 9.70 | 151 | 135974 | 45409 | 63307488 |
Respiratory tract congestion | 12.45 | 9.70 | 73 | 136052 | 17759 | 63335138 |
Peripheral venous disease | 12.44 | 9.70 | 9 | 136116 | 15468 | 63337429 |
Cold urticaria | 12.44 | 9.70 | 6 | 136119 | 130 | 63352767 |
Gastric mucosa erythema | 12.43 | 9.70 | 8 | 136117 | 308 | 63352589 |
Suicide attempt | 12.41 | 9.70 | 78 | 136047 | 60840 | 63292057 |
Weight increased | 12.36 | 9.70 | 446 | 135679 | 260346 | 63092551 |
Wheezing | 12.33 | 9.70 | 280 | 135845 | 95315 | 63257582 |
Bradycardia foetal | 12.32 | 9.70 | 9 | 136116 | 427 | 63352470 |
Colour blindness | 12.31 | 9.70 | 8 | 136117 | 313 | 63352584 |
Hyperlactacidaemia | 12.30 | 9.70 | 22 | 136103 | 2827 | 63350070 |
Gamma-glutamyltransferase increased | 12.26 | 9.70 | 35 | 136090 | 33996 | 63318901 |
Food poisoning | 12.26 | 9.70 | 28 | 136097 | 4288 | 63348609 |
Administration site mass | 12.21 | 9.70 | 4 | 136121 | 29 | 63352868 |
Blindness | 12.16 | 9.70 | 84 | 136041 | 21615 | 63331282 |
Speech disorder | 12.15 | 9.70 | 137 | 135988 | 40492 | 63312405 |
Hypercapnia | 12.00 | 9.70 | 32 | 136093 | 5399 | 63347498 |
CSF pressure increased | 11.99 | 9.70 | 6 | 136119 | 141 | 63352756 |
Dysphemia | 11.99 | 9.70 | 21 | 136104 | 2654 | 63350243 |
Blood pressure immeasurable | 11.99 | 9.70 | 14 | 136111 | 1218 | 63351679 |
Procedural haemorrhage | 11.92 | 9.70 | 21 | 136104 | 2667 | 63350230 |
Diabetes mellitus inadequate control | 11.90 | 9.70 | 9 | 136116 | 15117 | 63337780 |
Ascites | 11.85 | 9.70 | 46 | 136079 | 40682 | 63312215 |
Diabetic ketoacidosis | 11.79 | 9.70 | 16 | 136109 | 20489 | 63332408 |
Left ventricular dysfunction | 11.79 | 9.70 | 54 | 136071 | 11934 | 63340963 |
Inadequate analgesia | 11.79 | 9.70 | 22 | 136103 | 2921 | 63349976 |
Spinal cord oedema | 11.77 | 9.70 | 6 | 136119 | 147 | 63352750 |
Irregular breathing | 11.73 | 9.70 | 8 | 136117 | 340 | 63352557 |
Transferrin decreased | 11.63 | 9.70 | 7 | 136118 | 239 | 63352658 |
Tooth abscess | 11.59 | 9.70 | 63 | 136062 | 14906 | 63337991 |
Anal sphincter atony | 11.52 | 9.70 | 7 | 136118 | 243 | 63352654 |
Lip disorder | 11.52 | 9.70 | 15 | 136110 | 1459 | 63351438 |
Vascular stenosis | 11.48 | 9.70 | 8 | 136117 | 352 | 63352545 |
Blood immunoglobulin G abnormal | 11.46 | 9.70 | 4 | 136121 | 36 | 63352861 |
Immunodeficiency | 11.45 | 9.70 | 16 | 136109 | 20238 | 63332659 |
Cutis laxa | 11.44 | 9.70 | 6 | 136119 | 156 | 63352741 |
Disseminated intravascular coagulation | 11.43 | 9.70 | 75 | 136050 | 18976 | 63333921 |
Implant site bruising | 11.42 | 9.70 | 8 | 136117 | 355 | 63352542 |
Visual acuity reduced | 11.36 | 9.70 | 83 | 136042 | 21743 | 63331154 |
Propionibacterium infection | 11.36 | 9.70 | 4 | 136121 | 37 | 63352860 |
Agranulocytosis | 11.31 | 9.70 | 23 | 136102 | 25111 | 63327786 |
Application site alopecia | 11.30 | 9.70 | 3 | 136122 | 9 | 63352888 |
Decreased ventricular preload | 11.30 | 9.70 | 3 | 136122 | 9 | 63352888 |
Palmar-plantar erythrodysaesthesia syndrome | 11.29 | 9.70 | 20 | 136105 | 22995 | 63329902 |
Hypoxic-ischaemic encephalopathy | 11.29 | 9.70 | 27 | 136098 | 4260 | 63348637 |
Night sweats | 11.29 | 9.70 | 60 | 136065 | 48754 | 63304143 |
Foetal heart rate abnormal | 11.28 | 9.70 | 10 | 136115 | 627 | 63352270 |
Mucosal inflammation | 11.23 | 9.70 | 57 | 136068 | 46871 | 63306026 |
Idiopathic urticaria | 11.22 | 9.70 | 7 | 136118 | 255 | 63352642 |
Hypoglycaemia | 11.19 | 9.70 | 79 | 136046 | 59986 | 63292911 |
XIIth nerve injury | 11.06 | 9.70 | 3 | 136122 | 10 | 63352887 |
Multiple sclerosis relapse | 10.98 | 9.70 | 60 | 136065 | 48418 | 63304479 |
Device use issue | 10.96 | 9.70 | 20 | 136105 | 2610 | 63350287 |
Treatment noncompliance | 10.96 | 9.70 | 42 | 136083 | 37283 | 63315614 |
Liver function test increased | 10.92 | 9.70 | 35 | 136090 | 32776 | 63320121 |
Electrocardiogram U wave present | 10.91 | 9.70 | 5 | 136120 | 96 | 63352801 |
Vascular resistance systemic decreased | 10.87 | 9.70 | 5 | 136120 | 97 | 63352800 |
Hemiplegic migraine | 10.87 | 9.70 | 5 | 136120 | 97 | 63352800 |
Epinephrine increased | 10.84 | 9.70 | 3 | 136122 | 11 | 63352886 |
Capillary nail refill test abnormal | 10.83 | 9.70 | 4 | 136121 | 43 | 63352854 |
Overdose | 10.75 | 9.70 | 323 | 135802 | 114755 | 63238142 |
Hyperkalaemia | 10.74 | 9.70 | 70 | 136055 | 54133 | 63298764 |
Cardiac arrest neonatal | 10.73 | 9.70 | 5 | 136120 | 100 | 63352797 |
Hypoxia | 10.70 | 9.70 | 184 | 135941 | 59608 | 63293289 |
Arthropod sting | 10.69 | 9.70 | 13 | 136112 | 1180 | 63351717 |
Sensitive skin | 10.64 | 9.70 | 16 | 136109 | 1780 | 63351117 |
Heliotrope rash | 10.64 | 9.70 | 6 | 136119 | 181 | 63352716 |
Rash maculo-papular | 10.63 | 9.70 | 34 | 136091 | 31862 | 63321035 |
Vocal cord disorder | 10.62 | 9.70 | 14 | 136111 | 1379 | 63351518 |
Sedation | 10.55 | 9.70 | 45 | 136080 | 38764 | 63314133 |
Infusion site hypersensitivity | 10.51 | 9.70 | 4 | 136121 | 47 | 63352850 |
Right ventricular dysfunction | 10.49 | 9.70 | 16 | 136109 | 1803 | 63351094 |
Medical device site infection | 10.48 | 9.70 | 7 | 136118 | 287 | 63352610 |
Infusion site haematoma | 10.46 | 9.70 | 7 | 136118 | 288 | 63352609 |
Victim of spousal abuse | 10.45 | 9.70 | 3 | 136122 | 13 | 63352884 |
Product administration error | 10.44 | 9.70 | 83 | 136042 | 22314 | 63330583 |
Intraocular pressure fluctuation | 10.43 | 9.70 | 4 | 136121 | 48 | 63352849 |
Orbital infection | 10.43 | 9.70 | 4 | 136121 | 48 | 63352849 |
Anaphylactoid syndrome of pregnancy | 10.43 | 9.70 | 4 | 136121 | 48 | 63352849 |
Cholestasis of pregnancy | 10.42 | 9.70 | 13 | 136112 | 1212 | 63351685 |
Premature delivery | 10.41 | 9.70 | 105 | 136020 | 30176 | 63322721 |
Low cardiac output syndrome | 10.36 | 9.70 | 8 | 136117 | 413 | 63352484 |
Pain in jaw | 10.32 | 9.70 | 53 | 136072 | 43443 | 63309454 |
Central venous catheter removal | 10.27 | 9.70 | 8 | 136117 | 418 | 63352479 |
Ocular retrobulbar haemorrhage | 10.25 | 9.70 | 5 | 136120 | 111 | 63352786 |
Injection site swelling | 10.25 | 9.70 | 151 | 135974 | 47421 | 63305476 |
Cardiovascular insufficiency | 10.24 | 9.70 | 14 | 136111 | 1427 | 63351470 |
Metapneumovirus infection | 10.24 | 9.70 | 12 | 136113 | 1048 | 63351849 |
Breast cancer stage II | 10.24 | 9.70 | 3 | 136122 | 8733 | 63344164 |
N-terminal prohormone brain natriuretic peptide | 10.21 | 9.70 | 4 | 136121 | 51 | 63352846 |
Brain stem syndrome | 10.21 | 9.70 | 8 | 136117 | 422 | 63352475 |
Orbital oedema | 10.17 | 9.70 | 7 | 136118 | 302 | 63352595 |
Infusion site injury | 10.14 | 9.70 | 4 | 136121 | 52 | 63352845 |
Post-acute COVID-19 syndrome | 10.11 | 9.70 | 8 | 136117 | 428 | 63352469 |
Coccygectomy | 10.10 | 9.70 | 3 | 136122 | 15 | 63352882 |
Vitamin E decreased | 10.10 | 9.70 | 3 | 136122 | 15 | 63352882 |
Nail bed infection bacterial | 10.10 | 9.70 | 3 | 136122 | 15 | 63352882 |
Arthritis fungal | 10.10 | 9.70 | 3 | 136122 | 15 | 63352882 |
Conduction disorder | 10.05 | 9.70 | 14 | 136111 | 1453 | 63351444 |
Biopsy lung | 10.04 | 9.70 | 6 | 136119 | 202 | 63352695 |
Foetal exposure during pregnancy | 10.02 | 9.70 | 35 | 136090 | 31927 | 63320970 |
Cataract | 10.00 | 9.70 | 175 | 135950 | 56878 | 63296019 |
Optic atrophy | 9.98 | 9.70 | 13 | 136112 | 1265 | 63351632 |
Eye infection staphylococcal | 9.98 | 9.70 | 5 | 136120 | 118 | 63352779 |
Hepatic cytolysis | 9.94 | 9.70 | 11 | 136114 | 15396 | 63337501 |
Hyperglycaemia | 9.94 | 9.70 | 51 | 136074 | 41816 | 63311081 |
Pneumocystis jirovecii pneumonia | 9.93 | 9.70 | 13 | 136112 | 16901 | 63335996 |
Muscle tension dysphonia | 9.88 | 9.70 | 6 | 136119 | 208 | 63352689 |
Chronic kidney disease | 9.84 | 9.70 | 57 | 136068 | 45341 | 63307556 |
Epidural haemorrhage | 9.82 | 9.70 | 5 | 136120 | 122 | 63352775 |
Allergy to immunoglobulin therapy | 9.81 | 9.70 | 4 | 136121 | 57 | 63352840 |
Vaginal abscess | 9.81 | 9.70 | 8 | 136117 | 447 | 63352450 |
Sinus bradycardia | 9.79 | 9.70 | 59 | 136066 | 14492 | 63338405 |
Iris hypopigmentation | 9.79 | 9.70 | 3 | 136122 | 17 | 63352880 |
Foot deformity | 9.77 | 9.70 | 29 | 136096 | 27824 | 63325073 |
Tremor | 9.76 | 9.70 | 361 | 135764 | 131878 | 63221019 |
Benign vulval neoplasm | 9.75 | 9.70 | 4 | 136121 | 58 | 63352839 |
Tuberculosis | 9.71 | 9.70 | 6 | 136119 | 11205 | 63341692 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Device failure | 372.58 | 10.53 | 150 | 69827 | 2226 | 34884728 |
Drug ineffective | 358.82 | 10.53 | 1828 | 68149 | 454923 | 34432031 |
Sinusitis | 353.47 | 10.53 | 425 | 69552 | 40977 | 34845977 |
Anaphylactic reaction | 353.05 | 10.53 | 377 | 69600 | 31924 | 34855030 |
Anaphylactic shock | 268.42 | 10.53 | 236 | 69741 | 15705 | 34871249 |
Anaesthetic complication | 244.62 | 10.53 | 90 | 69887 | 1030 | 34885924 |
Cardiac arrest | 242.30 | 10.53 | 570 | 69407 | 95589 | 34791365 |
Toxic anterior segment syndrome | 194.39 | 10.53 | 77 | 69900 | 1092 | 34885862 |
Methaemoglobinaemia | 178.73 | 10.53 | 103 | 69874 | 3478 | 34883476 |
Local anaesthetic systemic toxicity | 161.36 | 10.53 | 48 | 69929 | 262 | 34886692 |
Chondrolysis | 160.40 | 10.53 | 39 | 69938 | 79 | 34886875 |
Hereditary angioedema | 150.13 | 10.53 | 62 | 69915 | 985 | 34885969 |
Injury | 147.17 | 10.53 | 194 | 69783 | 20493 | 34866461 |
Fear | 146.86 | 10.53 | 140 | 69837 | 10336 | 34876618 |
Hypotension | 141.61 | 10.53 | 841 | 69136 | 220808 | 34666146 |
Ear infection | 138.27 | 10.53 | 134 | 69843 | 10097 | 34876857 |
Renal injury | 135.35 | 10.53 | 138 | 69839 | 11057 | 34875897 |
Infusion site swelling | 129.72 | 10.53 | 74 | 69903 | 2450 | 34884504 |
Infusion site pain | 126.77 | 10.53 | 85 | 69892 | 3766 | 34883188 |
Stress cardiomyopathy | 123.97 | 10.53 | 67 | 69910 | 1992 | 34884962 |
Electrocardiogram ST segment elevation | 116.17 | 10.53 | 91 | 69886 | 5147 | 34881807 |
Ventricular tachycardia | 114.23 | 10.53 | 197 | 69780 | 26382 | 34860572 |
Emotional distress | 113.24 | 10.53 | 145 | 69832 | 14881 | 34872073 |
Bradycardia | 110.30 | 10.53 | 367 | 69610 | 75051 | 34811903 |
Anhedonia | 109.43 | 10.53 | 103 | 69874 | 7482 | 34879472 |
Kounis syndrome | 103.71 | 10.53 | 64 | 69913 | 2454 | 34884500 |
Accidental exposure to product | 100.37 | 10.53 | 126 | 69851 | 12676 | 34874278 |
Needle issue | 99.22 | 10.53 | 89 | 69888 | 6076 | 34880878 |
Infusion site extravasation | 97.49 | 10.53 | 76 | 69901 | 4268 | 34882686 |
Ventricular fibrillation | 97.16 | 10.53 | 169 | 69808 | 22785 | 34864169 |
Injection site pallor | 93.90 | 10.53 | 19 | 69958 | 6 | 34886948 |
Injection site laceration | 92.59 | 10.53 | 20 | 69957 | 16 | 34886938 |
Arteriospasm coronary | 88.82 | 10.53 | 65 | 69912 | 3317 | 34883637 |
Upper respiratory tract infection | 87.50 | 10.53 | 200 | 69777 | 32859 | 34854095 |
Lagophthalmos | 85.87 | 10.53 | 23 | 69954 | 79 | 34886875 |
Unevaluable event | 83.87 | 10.53 | 195 | 69782 | 32395 | 34854559 |
Drug ineffective for unapproved indication | 83.19 | 10.53 | 161 | 69816 | 23554 | 34863400 |
Bronchospasm | 83.14 | 10.53 | 105 | 69872 | 10626 | 34876328 |
Diarrhoea | 82.38 | 10.53 | 452 | 69525 | 389460 | 34497494 |
Device use issue | 81.33 | 10.53 | 35 | 69942 | 619 | 34886335 |
Product quality issue | 80.83 | 10.53 | 132 | 69845 | 16903 | 34870051 |
Infusion site erythema | 79.24 | 10.53 | 52 | 69925 | 2221 | 34884733 |
Accidental exposure to product by child | 77.80 | 10.53 | 44 | 69933 | 1432 | 34885522 |
Stress | 76.37 | 10.53 | 180 | 69797 | 30167 | 34856787 |
COVID-19 | 74.32 | 10.53 | 330 | 69647 | 77220 | 34809734 |
Injury associated with device | 71.70 | 10.53 | 38 | 69939 | 1085 | 34885869 |
Completed suicide | 67.87 | 10.53 | 58 | 69919 | 98110 | 34788844 |
Tachycardia | 66.88 | 10.53 | 341 | 69636 | 84431 | 34802523 |
Expired product administered | 65.49 | 10.53 | 54 | 69923 | 3287 | 34883667 |
Incorrect route of product administration | 65.04 | 10.53 | 111 | 69866 | 14734 | 34872220 |
Pain | 61.51 | 10.53 | 653 | 69324 | 204022 | 34682932 |
Insurance issue | 60.00 | 10.53 | 42 | 69935 | 1997 | 34884957 |
General physical health deterioration | 59.85 | 10.53 | 103 | 69874 | 128166 | 34758788 |
Shock | 59.30 | 10.53 | 142 | 69835 | 24037 | 34862917 |
Infusion site pruritus | 58.71 | 10.53 | 30 | 69947 | 793 | 34886161 |
Hypoxic-ischaemic encephalopathy | 58.69 | 10.53 | 58 | 69919 | 4474 | 34882480 |
Disease progression | 57.90 | 10.53 | 79 | 69898 | 107998 | 34778956 |
Interstitial lung disease | 56.61 | 10.53 | 30 | 69947 | 65252 | 34821702 |
Anaemia | 55.67 | 10.53 | 259 | 69718 | 233076 | 34653878 |
Electrocardiogram QRS complex prolonged | 54.96 | 10.53 | 58 | 69919 | 4836 | 34882118 |
Decreased appetite | 54.53 | 10.53 | 162 | 69815 | 166230 | 34720724 |
Dermatitis atopic | 54.15 | 10.53 | 60 | 69917 | 5287 | 34881667 |
Vasoplegia syndrome | 54.08 | 10.53 | 38 | 69939 | 1818 | 34885136 |
Endophthalmitis | 53.23 | 10.53 | 49 | 69928 | 3459 | 34883495 |
Cardiogenic shock | 51.51 | 10.53 | 143 | 69834 | 26475 | 34860479 |
Injection site injury | 49.59 | 10.53 | 19 | 69958 | 245 | 34886709 |
Hyperthermia malignant | 48.66 | 10.53 | 38 | 69939 | 2139 | 34884815 |
Haemodynamic instability | 48.19 | 10.53 | 76 | 69901 | 9447 | 34877507 |
Metabolic acidosis | 47.33 | 10.53 | 193 | 69784 | 43487 | 34843467 |
Pulse absent | 46.90 | 10.53 | 58 | 69919 | 5745 | 34881209 |
Infusion site bruising | 46.88 | 10.53 | 25 | 69952 | 723 | 34886231 |
Unresponsive to stimuli | 46.50 | 10.53 | 141 | 69836 | 27428 | 34859526 |
Infusion site rash | 45.57 | 10.53 | 22 | 69955 | 513 | 34886441 |
Overdose | 45.37 | 10.53 | 325 | 69652 | 90734 | 34796220 |
Sinus tachycardia | 44.79 | 10.53 | 104 | 69873 | 17256 | 34869698 |
Accidental overdose | 43.82 | 10.53 | 113 | 69864 | 20027 | 34866927 |
Multiple allergies | 43.74 | 10.53 | 41 | 69936 | 2962 | 34883992 |
Multiple organ dysfunction syndrome | 43.33 | 10.53 | 282 | 69695 | 76284 | 34810670 |
Urticaria | 41.78 | 10.53 | 240 | 69737 | 62137 | 34824817 |
Cauda equina syndrome | 40.76 | 10.53 | 21 | 69956 | 565 | 34886389 |
Asthenia | 40.53 | 10.53 | 306 | 69671 | 244945 | 34642009 |
Respiratory tract infection | 40.23 | 10.53 | 108 | 69869 | 19604 | 34867350 |
Generalised tonic-clonic seizure | 40.23 | 10.53 | 113 | 69864 | 21061 | 34865893 |
Leukopenia | 40.04 | 10.53 | 40 | 69937 | 62816 | 34824138 |
Pulseless electrical activity | 39.93 | 10.53 | 60 | 69917 | 7151 | 34879803 |
Nasopharyngitis | 39.77 | 10.53 | 258 | 69719 | 69710 | 34817244 |
Respiratory depression | 39.39 | 10.53 | 95 | 69882 | 16150 | 34870804 |
Incorrect drug administration rate | 38.63 | 10.53 | 30 | 69947 | 1675 | 34885279 |
Hypoxia | 38.22 | 10.53 | 214 | 69763 | 54881 | 34832073 |
Illness | 38.19 | 10.53 | 84 | 69893 | 13445 | 34873509 |
Corneal reflex decreased | 38.14 | 10.53 | 14 | 69963 | 159 | 34886795 |
Toxicity to various agents | 37.89 | 10.53 | 587 | 69390 | 199775 | 34687179 |
Wrong product administered | 37.88 | 10.53 | 50 | 69927 | 5284 | 34881670 |
Hypersensitivity | 37.76 | 10.53 | 230 | 69747 | 60805 | 34826149 |
Seasonal allergy | 37.62 | 10.53 | 56 | 69921 | 6619 | 34880335 |
Malignant neoplasm progression | 37.24 | 10.53 | 75 | 69902 | 87971 | 34798983 |
Injection site coldness | 37.09 | 10.53 | 9 | 69968 | 18 | 34886936 |
Thrombocytopenia | 36.88 | 10.53 | 174 | 69803 | 156073 | 34730881 |
Infusion related reaction | 36.75 | 10.53 | 206 | 69771 | 52851 | 34834103 |
Acute kidney injury | 35.98 | 10.53 | 414 | 69563 | 304574 | 34582380 |
Impaired quality of life | 35.98 | 10.53 | 51 | 69926 | 5767 | 34881187 |
Anaesthetic complication neurological | 35.25 | 10.53 | 16 | 69961 | 323 | 34886631 |
Injection site pain | 35.10 | 10.53 | 163 | 69814 | 38842 | 34848112 |
Infusion site haemorrhage | 35.07 | 10.53 | 23 | 69954 | 981 | 34885973 |
Neuromuscular block prolonged | 34.98 | 10.53 | 18 | 69959 | 483 | 34886471 |
Liquid product physical issue | 34.95 | 10.53 | 18 | 69959 | 484 | 34886470 |
Post procedural complication | 34.78 | 10.53 | 73 | 69904 | 11315 | 34875639 |
Infusion site nodule | 34.51 | 10.53 | 12 | 69965 | 115 | 34886839 |
Mydriasis | 34.22 | 10.53 | 56 | 69921 | 7181 | 34879773 |
Pancytopenia | 33.84 | 10.53 | 89 | 69888 | 95068 | 34791886 |
Corneal oedema | 33.31 | 10.53 | 25 | 69952 | 1326 | 34885628 |
Factor V Leiden mutation | 33.27 | 10.53 | 11 | 69966 | 89 | 34886865 |
Ventricular extrasystoles | 33.26 | 10.53 | 74 | 69903 | 11934 | 34875020 |
Haemoglobin decreased | 33.10 | 10.53 | 127 | 69850 | 120645 | 34766309 |
Hyperdynamic left ventricle | 33.03 | 10.53 | 13 | 69964 | 181 | 34886773 |
Death | 32.95 | 10.53 | 580 | 69397 | 397469 | 34489485 |
White blood cell count decreased | 32.64 | 10.53 | 91 | 69886 | 95354 | 34791600 |
Rheumatoid arthritis | 32.51 | 10.53 | 18 | 69959 | 38220 | 34848734 |
Neutropenia | 32.25 | 10.53 | 183 | 69794 | 156595 | 34730359 |
Medical device site laceration | 31.29 | 10.53 | 6 | 69971 | 0 | 34886954 |
Weight decreased | 31.01 | 10.53 | 216 | 69761 | 176085 | 34710869 |
Eyelid rash | 30.74 | 10.53 | 9 | 69968 | 46 | 34886908 |
Coma | 30.74 | 10.53 | 176 | 69801 | 45502 | 34841452 |
Psoriasis | 30.58 | 10.53 | 20 | 69957 | 38792 | 34848162 |
Administration site pain | 30.42 | 10.53 | 14 | 69963 | 292 | 34886662 |
Retinal artery occlusion | 29.91 | 10.53 | 27 | 69950 | 1858 | 34885096 |
Cardiotoxicity | 29.87 | 10.53 | 46 | 69931 | 5602 | 34881352 |
Swollen tongue | 29.78 | 10.53 | 80 | 69897 | 14525 | 34872429 |
Anal inflammation | 29.72 | 10.53 | 23 | 69954 | 1277 | 34885677 |
Melaena | 29.59 | 10.53 | 17 | 69960 | 35363 | 34851591 |
Delayed recovery from anaesthesia | 29.58 | 10.53 | 19 | 69958 | 782 | 34886172 |
Procedural haemorrhage | 29.17 | 10.53 | 30 | 69947 | 2427 | 34884527 |
Cardiac failure congestive | 28.76 | 10.53 | 79 | 69898 | 83191 | 34803763 |
Anxiety | 28.75 | 10.53 | 315 | 69662 | 99113 | 34787841 |
Eye infection | 28.54 | 10.53 | 36 | 69941 | 3637 | 34883317 |
Oculocardiac reflex | 28.48 | 10.53 | 9 | 69968 | 62 | 34886892 |
Asthma | 28.47 | 10.53 | 164 | 69813 | 42492 | 34844462 |
Administration site swelling | 28.26 | 10.53 | 12 | 69965 | 205 | 34886749 |
Laryngeal oedema | 28.25 | 10.53 | 35 | 69942 | 3473 | 34883481 |
Coagulation factor deficiency | 28.22 | 10.53 | 11 | 69966 | 149 | 34886805 |
Mean arterial pressure decreased | 28.09 | 10.53 | 11 | 69966 | 151 | 34886803 |
Oedema peripheral | 27.92 | 10.53 | 134 | 69843 | 119678 | 34767276 |
Angioedema | 27.82 | 10.53 | 148 | 69829 | 37226 | 34849728 |
Brain oedema | 27.48 | 10.53 | 75 | 69902 | 13746 | 34873208 |
Spinal cord infarction | 27.45 | 10.53 | 13 | 69964 | 290 | 34886664 |
Coronary artery disease | 27.19 | 10.53 | 34 | 69943 | 48271 | 34838683 |
Bronchopulmonary aspergillosis allergic | 27.02 | 10.53 | 19 | 69958 | 910 | 34886044 |
Apnoea | 26.81 | 10.53 | 48 | 69929 | 6616 | 34880338 |
Drug intolerance | 26.70 | 10.53 | 49 | 69928 | 59521 | 34827433 |
Dehydration | 26.56 | 10.53 | 152 | 69825 | 129817 | 34757137 |
Systolic anterior motion of mitral valve | 25.50 | 10.53 | 7 | 69970 | 27 | 34886927 |
Injection site hypoaesthesia | 25.45 | 10.53 | 9 | 69968 | 91 | 34886863 |
Agranulocytosis | 25.42 | 10.53 | 8 | 69969 | 23813 | 34863141 |
Brain stem syndrome | 24.91 | 10.53 | 15 | 69962 | 550 | 34886404 |
Gastroenteritis viral | 24.53 | 10.53 | 48 | 69929 | 7076 | 34879878 |
Myocardial stunning | 24.40 | 10.53 | 6 | 69971 | 13 | 34886941 |
Hypopyon | 24.16 | 10.53 | 13 | 69964 | 383 | 34886571 |
Cyanosis | 24.12 | 10.53 | 68 | 69909 | 12696 | 34874258 |
Tryptase increased | 24.05 | 10.53 | 11 | 69966 | 226 | 34886728 |
Product dose omission issue | 23.85 | 10.53 | 354 | 69623 | 119357 | 34767597 |
Electrocardiogram ST segment depression | 23.80 | 10.53 | 27 | 69950 | 2441 | 34884513 |
Ventricular arrhythmia | 23.77 | 10.53 | 41 | 69936 | 5487 | 34881467 |
Removal of foreign body | 23.72 | 10.53 | 7 | 69970 | 37 | 34886917 |
Macroglossia | 23.71 | 10.53 | 13 | 69964 | 398 | 34886556 |
Chemical burn | 23.45 | 10.53 | 11 | 69966 | 240 | 34886714 |
Platelet count decreased | 23.40 | 10.53 | 142 | 69835 | 119575 | 34767379 |
SARS-CoV-2 test negative | 23.22 | 10.53 | 18 | 69959 | 1002 | 34885952 |
Injection site discolouration | 22.93 | 10.53 | 21 | 69956 | 1472 | 34885482 |
Trigemino-cardiac reflex | 22.92 | 10.53 | 10 | 69967 | 183 | 34886771 |
Blood pressure decreased | 22.88 | 10.53 | 179 | 69798 | 51336 | 34835618 |
Pancreatitis acute | 22.86 | 10.53 | 14 | 69963 | 28127 | 34858827 |
Aqueous fibrin | 22.83 | 10.53 | 7 | 69970 | 43 | 34886911 |
Blood pressure fluctuation | 22.78 | 10.53 | 11 | 69966 | 25238 | 34861716 |
Hypoglycaemia | 22.71 | 10.53 | 47 | 69930 | 54593 | 34832361 |
Pulmonary oedema | 22.70 | 10.53 | 168 | 69809 | 47361 | 34839593 |
Headache | 22.23 | 10.53 | 542 | 69435 | 200093 | 34686861 |
Circulatory collapse | 22.02 | 10.53 | 92 | 69885 | 20946 | 34866008 |
Anal sphincter atony | 21.94 | 10.53 | 8 | 69969 | 89 | 34886865 |
Gastrointestinal haemorrhage | 21.76 | 10.53 | 97 | 69880 | 88380 | 34798574 |
Croup infectious | 21.60 | 10.53 | 12 | 69965 | 377 | 34886577 |
Prostate cancer | 21.19 | 10.53 | 29 | 69948 | 39620 | 34847334 |
International normalised ratio increased | 21.15 | 10.53 | 39 | 69938 | 47288 | 34839666 |
Respiratory acidosis | 21.12 | 10.53 | 37 | 69940 | 5013 | 34881941 |
Embolia cutis medicamentosa | 20.88 | 10.53 | 10 | 69967 | 229 | 34886725 |
Dyspnoea exertional | 20.85 | 10.53 | 34 | 69943 | 43245 | 34843709 |
Respiratory arrest | 20.83 | 10.53 | 111 | 69866 | 27932 | 34859022 |
Transient ischaemic attack | 20.72 | 10.53 | 15 | 69962 | 27598 | 34859356 |
Left ventricle outflow tract obstruction | 20.67 | 10.53 | 9 | 69968 | 164 | 34886790 |
Jaundice | 20.63 | 10.53 | 20 | 69957 | 31862 | 34855092 |
Suicide attempt | 20.52 | 10.53 | 29 | 69948 | 39087 | 34847867 |
Loss of consciousness | 20.37 | 10.53 | 254 | 69723 | 82413 | 34804541 |
Myalgia | 20.21 | 10.53 | 93 | 69884 | 84017 | 34802937 |
Procedural hypotension | 20.19 | 10.53 | 16 | 69961 | 920 | 34886034 |
Device malfunction | 20.17 | 10.53 | 56 | 69921 | 10365 | 34876589 |
Infusion site mass | 20.11 | 10.53 | 11 | 69966 | 335 | 34886619 |
Procedural complication | 20.06 | 10.53 | 33 | 69944 | 4250 | 34882704 |
Allergy to arthropod sting | 19.97 | 10.53 | 8 | 69969 | 117 | 34886837 |
Accident | 19.85 | 10.53 | 36 | 69941 | 5011 | 34881943 |
Neuromuscular blockade | 19.79 | 10.53 | 10 | 69967 | 258 | 34886696 |
Chondromalacia | 19.70 | 10.53 | 5 | 69972 | 13 | 34886941 |
Administration site erythema | 19.69 | 10.53 | 7 | 69970 | 72 | 34886882 |
Pupil fixed | 19.61 | 10.53 | 21 | 69956 | 1780 | 34885174 |
Hepatocellular injury | 19.55 | 10.53 | 10 | 69967 | 22201 | 34864753 |
Skin texture abnormal | 19.42 | 10.53 | 6 | 69971 | 38 | 34886916 |
Product use in unapproved indication | 19.11 | 10.53 | 336 | 69641 | 117163 | 34769791 |
Myocardial infarction | 19.05 | 10.53 | 153 | 69824 | 120932 | 34766022 |
Coagulation factor V level abnormal | 18.78 | 10.53 | 6 | 69971 | 43 | 34886911 |
Familial periodic paralysis | 18.72 | 10.53 | 7 | 69970 | 84 | 34886870 |
Alopecia | 18.58 | 10.53 | 13 | 69964 | 24342 | 34862612 |
Skin infection | 18.49 | 10.53 | 45 | 69932 | 7692 | 34879262 |
Haematuria | 18.42 | 10.53 | 46 | 69931 | 50020 | 34836934 |
Neoplasm progression | 18.36 | 10.53 | 12 | 69965 | 23288 | 34863666 |
Drug resistance | 18.29 | 10.53 | 15 | 69962 | 25912 | 34861042 |
Respiratory tract infection bacterial | 18.05 | 10.53 | 20 | 69957 | 1762 | 34885192 |
Atrioventricular block complete | 17.96 | 10.53 | 50 | 69927 | 9269 | 34877685 |
Intentional self-injury | 17.92 | 10.53 | 3 | 69974 | 13768 | 34873186 |
Musculoskeletal stiffness | 17.88 | 10.53 | 42 | 69935 | 46638 | 34840316 |
BRASH syndrome | 17.85 | 10.53 | 12 | 69965 | 534 | 34886420 |
Angina pectoris | 17.73 | 10.53 | 22 | 69955 | 31341 | 34855613 |
Intracranial hypotension | 17.71 | 10.53 | 9 | 69968 | 235 | 34886719 |
Oxygen saturation decreased | 17.66 | 10.53 | 175 | 69802 | 53643 | 34833311 |
Drug-induced liver injury | 17.62 | 10.53 | 19 | 69958 | 28813 | 34858141 |
Drug interaction | 17.44 | 10.53 | 333 | 69644 | 225613 | 34661341 |
Mouth swelling | 17.38 | 10.53 | 20 | 69957 | 1836 | 34885118 |
Cytomegalovirus infection | 17.37 | 10.53 | 16 | 69961 | 26119 | 34860835 |
Coma neonatal | 17.34 | 10.53 | 5 | 69972 | 24 | 34886930 |
Cholestasis | 17.32 | 10.53 | 17 | 69960 | 26931 | 34860023 |
Phaeochromocytoma crisis | 17.30 | 10.53 | 6 | 69971 | 57 | 34886897 |
Hyponatraemia | 17.26 | 10.53 | 96 | 69881 | 82595 | 34804359 |
Pharyngeal swelling | 17.23 | 10.53 | 22 | 69955 | 2250 | 34884704 |
Anion gap | 16.97 | 10.53 | 14 | 69963 | 853 | 34886101 |
Respiratory tract infection viral | 16.96 | 10.53 | 23 | 69954 | 2494 | 34884460 |
Insomnia | 16.94 | 10.53 | 130 | 69847 | 103777 | 34783177 |
Cardiac arrest neonatal | 16.85 | 10.53 | 5 | 69972 | 27 | 34886927 |
Infusion site irritation | 16.67 | 10.53 | 9 | 69968 | 267 | 34886687 |
Anterior chamber cell | 16.65 | 10.53 | 10 | 69967 | 365 | 34886589 |
Bronchitis | 16.57 | 10.53 | 142 | 69835 | 41821 | 34845133 |
Diabetes mellitus | 16.53 | 10.53 | 44 | 69933 | 46829 | 34840125 |
Reperfusion arrhythmia | 16.52 | 10.53 | 6 | 69971 | 66 | 34886888 |
Bladder cancer | 16.44 | 10.53 | 6 | 69971 | 16272 | 34870682 |
Seizure like phenomena | 16.35 | 10.53 | 13 | 69964 | 751 | 34886203 |
Hallucination | 16.22 | 10.53 | 51 | 69926 | 51447 | 34835507 |
Fatigue | 16.01 | 10.53 | 594 | 69383 | 370059 | 34516895 |
Orthostatic hypotension | 15.93 | 10.53 | 17 | 69960 | 25902 | 34861052 |
Catecholamine crisis | 15.88 | 10.53 | 5 | 69972 | 34 | 34886920 |
Administration site irritation | 15.87 | 10.53 | 4 | 69973 | 10 | 34886944 |
Ophthalmoplegia | 15.86 | 10.53 | 19 | 69958 | 1821 | 34885133 |
Eyelid oedema | 15.82 | 10.53 | 33 | 69944 | 5091 | 34881863 |
Seizure | 15.70 | 10.53 | 296 | 69681 | 104561 | 34782393 |
Administration site scar | 15.65 | 10.53 | 3 | 69974 | 0 | 34886954 |
Injection site extravasation | 15.61 | 10.53 | 24 | 69953 | 2918 | 34884036 |
Abdominal pain | 15.59 | 10.53 | 232 | 69745 | 163386 | 34723568 |
Food allergy | 15.59 | 10.53 | 17 | 69960 | 1471 | 34885483 |
Medication error | 15.58 | 10.53 | 96 | 69881 | 25469 | 34861485 |
Hepatitis | 15.46 | 10.53 | 15 | 69962 | 23889 | 34863065 |
Injection site scar | 15.40 | 10.53 | 9 | 69968 | 312 | 34886642 |
Paraesthesia oral | 15.33 | 10.53 | 29 | 69948 | 4168 | 34882786 |
Rhinitis | 15.29 | 10.53 | 37 | 69940 | 6301 | 34880653 |
Throat tightness | 15.28 | 10.53 | 44 | 69933 | 8314 | 34878640 |
Dry gangrene | 15.20 | 10.53 | 10 | 69967 | 429 | 34886525 |
Pulmonary fibrosis | 15.15 | 10.53 | 9 | 69968 | 18387 | 34868567 |
Areflexia | 15.07 | 10.53 | 24 | 69953 | 3007 | 34883947 |
Gamma-glutamyltransferase increased | 15.00 | 10.53 | 22 | 69955 | 29209 | 34857745 |
Tracheitis | 14.96 | 10.53 | 12 | 69965 | 702 | 34886252 |
Liver disorder | 14.91 | 10.53 | 27 | 69950 | 32970 | 34853984 |
Myopathy toxic | 14.80 | 10.53 | 11 | 69966 | 575 | 34886379 |
Haematochezia | 14.71 | 10.53 | 46 | 69931 | 46488 | 34840466 |
Vitritis | 14.61 | 10.53 | 13 | 69964 | 878 | 34886076 |
Product adhesion issue | 14.58 | 10.53 | 17 | 69960 | 1583 | 34885371 |
Vitreous disorder | 14.54 | 10.53 | 6 | 69971 | 95 | 34886859 |
Accelerated idioventricular rhythm | 14.51 | 10.53 | 7 | 69970 | 163 | 34886791 |
Pneumocystis jirovecii pneumonia | 14.41 | 10.53 | 11 | 69966 | 19699 | 34867255 |
COVID-19 immunisation | 14.41 | 10.53 | 8 | 69969 | 251 | 34886703 |
Pharyngitis streptococcal | 14.39 | 10.53 | 22 | 69955 | 2662 | 34884292 |
Electrocardiogram T wave amplitude increased | 14.37 | 10.53 | 5 | 69972 | 48 | 34886906 |
Injury corneal | 14.26 | 10.53 | 4 | 69973 | 17 | 34886937 |
Respiratory distress | 14.25 | 10.53 | 121 | 69856 | 35544 | 34851410 |
Torsade de pointes | 14.21 | 10.53 | 39 | 69938 | 7170 | 34879784 |
Polyneuropathy | 14.20 | 10.53 | 6 | 69971 | 14890 | 34872064 |
Paralysis | 14.14 | 10.53 | 35 | 69942 | 6047 | 34880907 |
Drug reaction with eosinophilia and systemic symptoms | 14.05 | 10.53 | 28 | 69949 | 32984 | 34853970 |
Cardiac failure | 14.02 | 10.53 | 116 | 69861 | 91132 | 34795822 |
Viral infection | 13.95 | 10.53 | 71 | 69906 | 17552 | 34869402 |
Hepatic function abnormal | 13.92 | 10.53 | 44 | 69933 | 44319 | 34842635 |
Blood lactic acid increased | 13.86 | 10.53 | 37 | 69940 | 6691 | 34880263 |
Alanine aminotransferase increased | 13.70 | 10.53 | 100 | 69877 | 80715 | 34806239 |
Pupillary reflex impaired | 13.61 | 10.53 | 16 | 69961 | 1503 | 34885451 |
Administration site pruritus | 13.58 | 10.53 | 4 | 69973 | 21 | 34886933 |
General anaesthesia | 13.57 | 10.53 | 3 | 69974 | 3 | 34886951 |
Toxic epidermal necrolysis | 13.52 | 10.53 | 14 | 69963 | 21632 | 34865322 |
Type I hypersensitivity | 13.51 | 10.53 | 15 | 69962 | 1324 | 34885630 |
Sinus arrest | 13.43 | 10.53 | 17 | 69960 | 1723 | 34885231 |
Vitreous floaters | 13.38 | 10.53 | 25 | 69952 | 3560 | 34883394 |
Product distribution issue | 13.36 | 10.53 | 11 | 69966 | 668 | 34886286 |
Recalled product administered | 13.31 | 10.53 | 10 | 69967 | 531 | 34886423 |
Disease recurrence | 13.31 | 10.53 | 14 | 69963 | 21476 | 34865478 |
Spinal cord oedema | 13.30 | 10.53 | 7 | 69970 | 197 | 34886757 |
Constipation | 13.13 | 10.53 | 194 | 69783 | 136788 | 34750166 |
Electrocardiogram ST-T segment depression | 13.11 | 10.53 | 3 | 69974 | 4 | 34886950 |
Retinal vasculitis | 13.06 | 10.53 | 9 | 69968 | 417 | 34886537 |
Paraplegia | 13.06 | 10.53 | 22 | 69955 | 2889 | 34884065 |
Respiratory syncytial virus infection | 13.02 | 10.53 | 29 | 69948 | 4680 | 34882274 |
Gas gangrene | 12.88 | 10.53 | 5 | 69972 | 67 | 34886887 |
Infusion site vesicles | 12.77 | 10.53 | 7 | 69970 | 214 | 34886740 |
Neuralgia | 12.75 | 10.53 | 62 | 69915 | 15051 | 34871903 |
Blood creatinine increased | 12.73 | 10.53 | 125 | 69852 | 94851 | 34792103 |
Device infusion issue | 12.73 | 10.53 | 12 | 69965 | 873 | 34886081 |
Liver function test abnormal | 12.68 | 10.53 | 27 | 69950 | 31047 | 34855907 |
Corneal opacity | 12.60 | 10.53 | 10 | 69967 | 576 | 34886378 |
Injection site joint infection | 12.60 | 10.53 | 4 | 69973 | 28 | 34886926 |
Foreign body | 12.54 | 10.53 | 13 | 69964 | 1061 | 34885893 |
Stridor | 12.51 | 10.53 | 20 | 69957 | 2514 | 34884440 |
Injection site discharge | 12.51 | 10.53 | 7 | 69970 | 223 | 34886731 |
Deep vein thrombosis | 12.42 | 10.53 | 78 | 69899 | 65170 | 34821784 |
End-tidal CO2 decreased | 12.36 | 10.53 | 3 | 69974 | 6 | 34886948 |
Proctalgia | 12.33 | 10.53 | 32 | 69945 | 5691 | 34881263 |
Gait disturbance | 12.30 | 10.53 | 110 | 69867 | 85030 | 34801924 |
Bone marrow failure | 12.29 | 10.53 | 25 | 69952 | 29228 | 34857726 |
Weight increased | 12.24 | 10.53 | 123 | 69854 | 92910 | 34794044 |
Pharyngeal oedema | 12.20 | 10.53 | 33 | 69944 | 6014 | 34880940 |
Hypercalcaemia | 12.14 | 10.53 | 8 | 69969 | 15460 | 34871494 |
Infusion site infection | 12.11 | 10.53 | 9 | 69968 | 470 | 34886484 |
Non-infectious endophthalmitis | 11.90 | 10.53 | 6 | 69971 | 154 | 34886800 |
Infusion site urticaria | 11.87 | 10.53 | 6 | 69971 | 155 | 34886799 |
Administration site reaction | 11.74 | 10.53 | 5 | 69972 | 86 | 34886868 |
Myoclonic epilepsy | 11.74 | 10.53 | 13 | 69964 | 1144 | 34885810 |
Joint swelling | 11.71 | 10.53 | 71 | 69906 | 59819 | 34827135 |
Ventricular tachyarrhythmia | 11.70 | 10.53 | 8 | 69969 | 366 | 34886588 |
Myokymia | 11.69 | 10.53 | 5 | 69972 | 87 | 34886867 |
Malaise | 11.67 | 10.53 | 283 | 69694 | 185542 | 34701412 |
Eye inflammation | 11.64 | 10.53 | 18 | 69959 | 2200 | 34884754 |
Tubulointerstitial nephritis | 11.62 | 10.53 | 15 | 69962 | 21009 | 34865945 |
Product administered at inappropriate site | 11.53 | 10.53 | 18 | 69959 | 2218 | 34884736 |
Migraine | 11.53 | 10.53 | 67 | 69910 | 17411 | 34869543 |
Anaphylactoid shock | 11.43 | 10.53 | 8 | 69969 | 380 | 34886574 |
Multiple sclerosis relapse | 11.43 | 10.53 | 6 | 69971 | 13127 | 34873827 |
Red blood cell count decreased | 11.28 | 10.53 | 26 | 69951 | 29064 | 34857890 |
Quadriplegia | 11.27 | 10.53 | 16 | 69961 | 1811 | 34885143 |
Burkholderia test positive | 11.27 | 10.53 | 12 | 69965 | 1011 | 34885943 |
Compartment syndrome | 11.21 | 10.53 | 21 | 69956 | 2997 | 34883957 |
Syncope | 11.18 | 10.53 | 123 | 69854 | 91328 | 34795626 |
Administration related reaction | 11.15 | 10.53 | 5 | 69972 | 98 | 34886856 |
Laryngeal stenosis | 11.15 | 10.53 | 5 | 69972 | 98 | 34886856 |
Foetal exposure during pregnancy | 11.12 | 10.53 | 39 | 69938 | 38062 | 34848892 |
Blood pressure systolic increased | 11.08 | 10.53 | 18 | 69959 | 22934 | 34864020 |
Nodal rhythm | 10.99 | 10.53 | 14 | 69963 | 1429 | 34885525 |
Treatment noncompliance | 10.98 | 10.53 | 25 | 69952 | 28075 | 34858879 |
Intestinal haematoma | 10.97 | 10.53 | 5 | 69972 | 102 | 34886852 |
Infusion site reaction | 10.92 | 10.53 | 11 | 69966 | 868 | 34886086 |
Diabetic ketoacidosis | 10.89 | 10.53 | 12 | 69965 | 18020 | 34868934 |
Chronic kidney disease | 10.85 | 10.53 | 44 | 69933 | 41166 | 34845788 |
Oral lichen planus | 10.84 | 10.53 | 6 | 69971 | 187 | 34886767 |
Metastases to liver | 10.81 | 10.53 | 7 | 69970 | 13656 | 34873298 |
Apgar score low | 10.76 | 10.53 | 11 | 69966 | 884 | 34886070 |
Foetal exposure during delivery | 10.75 | 10.53 | 5 | 69972 | 107 | 34886847 |
Brown-Sequard syndrome | 10.70 | 10.53 | 4 | 69973 | 48 | 34886906 |
Penile vascular disorder | 10.65 | 10.53 | 3 | 69974 | 13 | 34886941 |
Thrombotic microangiopathy | 10.60 | 10.53 | 4 | 69973 | 10626 | 34876328 |
Nephropathy toxic | 10.59 | 10.53 | 6 | 69971 | 12582 | 34874372 |
Hypoaesthesia oral | 10.54 | 10.53 | 25 | 69952 | 4204 | 34882750 |
Blood creatine phosphokinase increased | 10.53 | 10.53 | 50 | 69927 | 44807 | 34842147 |
Wheezing | 10.53 | 10.53 | 128 | 69849 | 41274 | 34845680 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Anaphylactic reaction | 720.44 | 9.42 | 860 | 157610 | 82883 | 79503035 |
Stress cardiomyopathy | 626.92 | 9.42 | 346 | 158124 | 10820 | 79575098 |
Local anaesthetic systemic toxicity | 614.95 | 9.42 | 178 | 158292 | 876 | 79585042 |
Toxic anterior segment syndrome | 531.79 | 9.42 | 202 | 158268 | 2562 | 79583356 |
Cardiac arrest | 526.57 | 9.42 | 1098 | 157372 | 170998 | 79414920 |
Anaesthetic complication | 496.74 | 9.42 | 194 | 158276 | 2665 | 79583253 |
Anaphylactic shock | 481.20 | 9.42 | 467 | 158003 | 35529 | 79550389 |
Hereditary angioedema | 380.63 | 9.42 | 194 | 158276 | 5141 | 79580777 |
Kounis syndrome | 365.76 | 9.42 | 176 | 158294 | 4106 | 79581812 |
Device failure | 348.68 | 9.42 | 193 | 158277 | 6068 | 79579850 |
Drug ineffective | 335.28 | 9.42 | 3444 | 155026 | 1077469 | 78508449 |
Chondrolysis | 331.17 | 9.42 | 87 | 158383 | 274 | 79585644 |
Sinusitis | 299.80 | 9.42 | 962 | 157508 | 194539 | 79391379 |
Hypotension | 268.41 | 9.42 | 1642 | 156828 | 438675 | 79147243 |
Completed suicide | 225.56 | 9.42 | 103 | 158367 | 245664 | 79340254 |
Bradycardia | 223.30 | 9.42 | 684 | 157786 | 134873 | 79451045 |
Ventricular tachycardia | 223.02 | 9.42 | 341 | 158129 | 41594 | 79544324 |
Fear | 210.95 | 9.42 | 239 | 158231 | 21747 | 79564171 |
Drug intolerance | 209.77 | 9.42 | 133 | 158337 | 263986 | 79321932 |
Lagophthalmos | 206.94 | 9.42 | 63 | 158407 | 380 | 79585538 |
Synovitis | 198.45 | 9.42 | 31 | 158439 | 150703 | 79435215 |
Contraindicated product administered | 197.29 | 9.42 | 37 | 158433 | 157501 | 79428417 |
Renal injury | 193.84 | 9.42 | 202 | 158268 | 16725 | 79569193 |
Joint swelling | 190.17 | 9.42 | 176 | 158294 | 288470 | 79297448 |
Methaemoglobinaemia | 184.56 | 9.42 | 123 | 158347 | 5434 | 79580484 |
Bronchospasm | 181.02 | 9.42 | 235 | 158235 | 24624 | 79561294 |
Infusion site swelling | 178.86 | 9.42 | 138 | 158332 | 7688 | 79578230 |
Pulseless electrical activity | 176.71 | 9.42 | 177 | 158293 | 13983 | 79571935 |
Infusion site pain | 174.71 | 9.42 | 176 | 158294 | 14000 | 79571918 |
Hand deformity | 172.63 | 9.42 | 8 | 158462 | 103911 | 79482007 |
COVID-19 | 168.48 | 9.42 | 690 | 157780 | 156984 | 79428934 |
General physical health deterioration | 168.45 | 9.42 | 179 | 158291 | 275059 | 79310859 |
Ventricular fibrillation | 167.49 | 9.42 | 258 | 158212 | 31668 | 79554250 |
Anhedonia | 165.62 | 9.42 | 175 | 158295 | 14723 | 79571195 |
Pemphigus | 161.19 | 9.42 | 9 | 158461 | 99573 | 79486345 |
Infusion site erythema | 157.94 | 9.42 | 139 | 158331 | 9321 | 79576597 |
Electrocardiogram ST segment elevation | 157.73 | 9.42 | 132 | 158338 | 8265 | 79577653 |
Infusion site extravasation | 155.85 | 9.42 | 142 | 158328 | 9966 | 79575952 |
Incorrect route of product administration | 152.89 | 9.42 | 260 | 158210 | 34669 | 79551249 |
Hepatic enzyme increased | 150.45 | 9.42 | 88 | 158382 | 182522 | 79403396 |
Anti-cyclic citrullinated peptide antibody positive | 150.28 | 9.42 | 3 | 158467 | 83140 | 79502778 |
Arteriospasm coronary | 143.90 | 9.42 | 114 | 158356 | 6602 | 79579316 |
Shock | 141.35 | 9.42 | 285 | 158185 | 43263 | 79542655 |
Cardiogenic shock | 136.87 | 9.42 | 275 | 158195 | 41639 | 79544279 |
Endophthalmitis | 135.35 | 9.42 | 108 | 158362 | 6320 | 79579598 |
Emotional distress | 135.04 | 9.42 | 266 | 158204 | 39703 | 79546215 |
Accidental exposure to product | 134.26 | 9.42 | 231 | 158239 | 31091 | 79554827 |
Infusion site pruritus | 134.00 | 9.42 | 90 | 158380 | 4028 | 79581890 |
Maternal exposure during delivery | 132.43 | 9.42 | 61 | 158409 | 1285 | 79584633 |
Unevaluable event | 132.04 | 9.42 | 321 | 158149 | 55264 | 79530654 |
Pericarditis | 131.52 | 9.42 | 24 | 158446 | 104212 | 79481706 |
Corneal oedema | 130.29 | 9.42 | 75 | 158395 | 2545 | 79583373 |
Rheumatoid arthritis | 129.28 | 9.42 | 134 | 158336 | 208336 | 79377582 |
Urticaria | 128.92 | 9.42 | 716 | 157754 | 184485 | 79401433 |
Product quality issue | 127.13 | 9.42 | 236 | 158234 | 33704 | 79552214 |
Tachycardia | 126.91 | 9.42 | 692 | 157778 | 177076 | 79408842 |
Diarrhoea | 125.99 | 9.42 | 1132 | 157338 | 879357 | 78706561 |
Glossodynia | 125.72 | 9.42 | 26 | 158444 | 103311 | 79482607 |
Impaired quality of life | 123.98 | 9.42 | 148 | 158322 | 14238 | 79571680 |
Insurance issue | 122.16 | 9.42 | 97 | 158373 | 5636 | 79580282 |
Arthropathy | 118.94 | 9.42 | 106 | 158364 | 177005 | 79408913 |
Illness | 113.04 | 9.42 | 271 | 158199 | 46240 | 79539678 |
Drug ineffective for unapproved indication | 112.34 | 9.42 | 287 | 158183 | 50951 | 79534967 |
Alopecia | 111.21 | 9.42 | 180 | 158290 | 231175 | 79354743 |
Cauda equina syndrome | 108.83 | 9.42 | 54 | 158416 | 1349 | 79584569 |
Upper respiratory tract infection | 106.19 | 9.42 | 410 | 158060 | 90758 | 79495160 |
Injection site pallor | 105.28 | 9.42 | 25 | 158445 | 44 | 79585874 |
Rheumatoid factor positive | 104.92 | 9.42 | 3 | 158467 | 59836 | 79526082 |
Haemodynamic instability | 104.85 | 9.42 | 150 | 158320 | 17232 | 79568686 |
Generalised tonic-clonic seizure | 104.73 | 9.42 | 254 | 158216 | 43656 | 79542262 |
Injury | 103.25 | 9.42 | 364 | 158106 | 77132 | 79508786 |
Ear infection | 103.11 | 9.42 | 218 | 158252 | 34214 | 79551704 |
Seasonal allergy | 101.06 | 9.42 | 143 | 158327 | 16263 | 79569655 |
Left ventricle outflow tract obstruction | 100.94 | 9.42 | 36 | 158434 | 377 | 79585541 |
Vasoplegia syndrome | 100.88 | 9.42 | 72 | 158398 | 3558 | 79582360 |
Bronchitis | 100.34 | 9.42 | 519 | 157951 | 130125 | 79455793 |
Helicobacter infection | 99.71 | 9.42 | 11 | 158459 | 69693 | 79516225 |
Infusion site bruising | 99.63 | 9.42 | 66 | 158404 | 2886 | 79583032 |
Pulse absent | 97.20 | 9.42 | 110 | 158360 | 9993 | 79575925 |
Sinus tachycardia | 96.18 | 9.42 | 221 | 158249 | 36687 | 79549231 |
Needle issue | 95.86 | 9.42 | 124 | 158346 | 12944 | 79572974 |
Arthralgia | 95.37 | 9.42 | 705 | 157765 | 571098 | 79014820 |
Stress | 94.33 | 9.42 | 360 | 158110 | 79252 | 79506666 |
Anaesthetic complication neurological | 92.14 | 9.42 | 38 | 158432 | 606 | 79585312 |
Therapeutic product effect decreased | 92.12 | 9.42 | 114 | 158356 | 163749 | 79422169 |
Unresponsive to stimuli | 88.52 | 9.42 | 278 | 158192 | 55510 | 79530408 |
Accidental overdose | 88.11 | 9.42 | 223 | 158247 | 39358 | 79546560 |
Musculoskeletal stiffness | 87.08 | 9.42 | 133 | 158337 | 174875 | 79411043 |
Stridor | 86.81 | 9.42 | 78 | 158392 | 5375 | 79580543 |
Infusion site haemorrhage | 85.89 | 9.42 | 66 | 158404 | 3654 | 79582264 |
Injury associated with device | 84.91 | 9.42 | 64 | 158406 | 3442 | 79582476 |
Multiple allergies | 82.65 | 9.42 | 103 | 158367 | 10357 | 79575561 |
Wound | 82.31 | 9.42 | 66 | 158404 | 116113 | 79469805 |
Systemic lupus erythematosus | 81.93 | 9.42 | 72 | 158398 | 121077 | 79464841 |
Decreased appetite | 81.72 | 9.42 | 376 | 158094 | 342042 | 79243876 |
Abdominal discomfort | 81.69 | 9.42 | 242 | 158228 | 250485 | 79335433 |
Incorrect drug administration rate | 81.28 | 9.42 | 66 | 158404 | 3960 | 79581958 |
Folliculitis | 81.11 | 9.42 | 8 | 158462 | 55372 | 79530546 |
Wrong product administered | 78.13 | 9.42 | 93 | 158377 | 8919 | 79576999 |
Injection site ischaemia | 77.78 | 9.42 | 16 | 158454 | 7 | 79585911 |
Hypopyon | 77.05 | 9.42 | 40 | 158430 | 1102 | 79584816 |
Injection site laceration | 75.54 | 9.42 | 22 | 158448 | 111 | 79585807 |
Post procedural complication | 75.00 | 9.42 | 154 | 158316 | 23675 | 79562243 |
Infusion site mass | 74.97 | 9.42 | 44 | 158426 | 1549 | 79584369 |
Metabolic acidosis | 74.93 | 9.42 | 344 | 158126 | 82185 | 79503733 |
Respiratory tract infection | 74.85 | 9.42 | 240 | 158230 | 48449 | 79537469 |
Disease progression | 73.12 | 9.42 | 161 | 158309 | 184201 | 79401717 |
Pulmonary oedema | 72.23 | 9.42 | 357 | 158113 | 87897 | 79498021 |
Expired product administered | 71.66 | 9.42 | 79 | 158391 | 6972 | 79578946 |
Neutropenia | 71.59 | 9.42 | 311 | 158159 | 287399 | 79298519 |
Acute kidney injury | 70.90 | 9.42 | 675 | 157795 | 518729 | 79067189 |
Asthenia | 70.69 | 9.42 | 663 | 157807 | 511026 | 79074892 |
Sleep disorder due to general medical condition, insomnia type | 70.28 | 9.42 | 4 | 158466 | 43552 | 79542366 |
Accidental exposure to product by child | 69.95 | 9.42 | 53 | 158417 | 2873 | 79583045 |
Anaemia | 69.73 | 9.42 | 558 | 157912 | 444457 | 79141461 |
Electrocardiogram QRS complex prolonged | 69.07 | 9.42 | 96 | 158374 | 10737 | 79575181 |
Electrocardiogram ST segment depression | 68.39 | 9.42 | 65 | 158405 | 4813 | 79581105 |
Swollen tongue | 66.49 | 9.42 | 211 | 158259 | 42359 | 79543559 |
Body tinea | 66.35 | 9.42 | 43 | 158427 | 1811 | 79584107 |
Muscle injury | 66.18 | 9.42 | 9 | 158461 | 48552 | 79537366 |
Angioedema | 66.13 | 9.42 | 313 | 158157 | 75722 | 79510196 |
Seizure | 65.25 | 9.42 | 617 | 157853 | 188217 | 79397701 |
Blood pressure decreased | 64.19 | 9.42 | 377 | 158093 | 99089 | 79486829 |
Procedural hypotension | 62.93 | 9.42 | 43 | 158427 | 1980 | 79583938 |
Tryptase increased | 62.40 | 9.42 | 29 | 158441 | 624 | 79585294 |
Overdose | 62.22 | 9.42 | 599 | 157871 | 183607 | 79402311 |
C-reactive protein abnormal | 61.30 | 9.42 | 11 | 158459 | 48356 | 79537562 |
Dermatitis atopic | 60.98 | 9.42 | 87 | 158383 | 9969 | 79575949 |
Respiratory depression | 60.80 | 9.42 | 155 | 158315 | 27475 | 79558443 |
Mobility decreased | 59.66 | 9.42 | 94 | 158376 | 122081 | 79463837 |
Psoriatic arthropathy | 59.52 | 9.42 | 41 | 158429 | 77958 | 79507960 |
Mydriasis | 59.08 | 9.42 | 117 | 158353 | 17526 | 79568392 |
Asthma | 58.47 | 9.42 | 464 | 158006 | 134631 | 79451287 |
Airway peak pressure increased | 58.42 | 9.42 | 23 | 158447 | 323 | 79585595 |
Injection site injury | 58.32 | 9.42 | 29 | 158441 | 728 | 79585190 |
Retinal artery occlusion | 58.21 | 9.42 | 50 | 158420 | 3244 | 79582674 |
Eyelid rash | 57.68 | 9.42 | 19 | 158451 | 153 | 79585765 |
Peripheral ischaemia | 57.61 | 9.42 | 82 | 158388 | 9375 | 79576543 |
Product dose omission issue | 57.61 | 9.42 | 748 | 157722 | 246789 | 79339129 |
Interstitial lung disease | 57.52 | 9.42 | 84 | 158386 | 112516 | 79473402 |
Hyperthermia malignant | 57.17 | 9.42 | 47 | 158423 | 2870 | 79583048 |
Impaired healing | 56.99 | 9.42 | 54 | 158416 | 87601 | 79498317 |
Hyponatraemia | 56.23 | 9.42 | 174 | 158296 | 177674 | 79408244 |
Lower respiratory tract infection | 56.19 | 9.42 | 107 | 158363 | 129113 | 79456805 |
Multiple organ dysfunction syndrome | 55.93 | 9.42 | 420 | 158050 | 119826 | 79466092 |
Hypoxic-ischaemic encephalopathy | 55.48 | 9.42 | 73 | 158397 | 7747 | 79578171 |
Malignant neoplasm progression | 55.37 | 9.42 | 117 | 158353 | 135873 | 79450045 |
Anxiety | 54.13 | 9.42 | 742 | 157728 | 247770 | 79338148 |
Pancytopenia | 53.94 | 9.42 | 160 | 158310 | 165585 | 79420333 |
COVID-19 immunisation | 53.92 | 9.42 | 34 | 158436 | 1365 | 79584553 |
Thrombocytopenia | 53.78 | 9.42 | 308 | 158162 | 264951 | 79320967 |
Circulatory collapse | 52.82 | 9.42 | 180 | 158290 | 37488 | 79548430 |
Device use issue | 52.77 | 9.42 | 44 | 158426 | 2740 | 79583178 |
Neuromuscular block prolonged | 52.60 | 9.42 | 30 | 158440 | 1000 | 79584918 |
Hyperaesthesia | 52.19 | 9.42 | 90 | 158380 | 12132 | 79573786 |
Cyanosis | 52.05 | 9.42 | 138 | 158332 | 25044 | 79560874 |
Liver injury | 51.45 | 9.42 | 24 | 158446 | 56590 | 79529328 |
Vitritis | 50.81 | 9.42 | 36 | 158434 | 1758 | 79584160 |
Cataract operation complication | 50.79 | 9.42 | 20 | 158450 | 281 | 79585637 |
Injection site coldness | 50.52 | 9.42 | 16 | 158454 | 112 | 79585806 |
Hypoaesthesia oral | 50.14 | 9.42 | 96 | 158374 | 14028 | 79571890 |
Hypoxia | 49.37 | 9.42 | 363 | 158107 | 102880 | 79483038 |
Intentional self-injury | 49.32 | 9.42 | 4 | 158466 | 32415 | 79553503 |
Type 2 diabetes mellitus | 49.22 | 9.42 | 26 | 158444 | 57096 | 79528822 |
Extradural abscess | 49.09 | 9.42 | 33 | 158437 | 1479 | 79584439 |
Toxicity to various agents | 48.63 | 9.42 | 1138 | 157332 | 420402 | 79165516 |
Loss of consciousness | 48.53 | 9.42 | 529 | 157941 | 167414 | 79418504 |
Leukopenia | 48.48 | 9.42 | 99 | 158371 | 116414 | 79469504 |
Apnoea | 48.43 | 9.42 | 85 | 158385 | 11619 | 79574299 |
Embolia cutis medicamentosa | 47.92 | 9.42 | 24 | 158446 | 612 | 79585306 |
Cholestasis | 47.50 | 9.42 | 22 | 158448 | 52087 | 79533831 |
Infusion site urticaria | 47.35 | 9.42 | 29 | 158441 | 1105 | 79584813 |
Ophthalmoplegia | 47.04 | 9.42 | 42 | 158428 | 2870 | 79583048 |
Anterior chamber cell | 46.75 | 9.42 | 27 | 158443 | 922 | 79584996 |
Extradural haematoma | 45.51 | 9.42 | 41 | 158429 | 2835 | 79583083 |
Procedural complication | 45.40 | 9.42 | 67 | 158403 | 7916 | 79578002 |
Paraplegia | 45.22 | 9.42 | 53 | 158417 | 5000 | 79580918 |
Rheumatic fever | 44.88 | 9.42 | 3 | 158467 | 28522 | 79557396 |
Ventricular extrasystoles | 44.88 | 9.42 | 112 | 158358 | 19592 | 79566326 |
Drug reaction with eosinophilia and systemic symptoms | 44.87 | 9.42 | 37 | 158433 | 64207 | 79521711 |
Removal of foreign body | 44.09 | 9.42 | 13 | 158457 | 69 | 79585849 |
Infection susceptibility increased | 43.67 | 9.42 | 45 | 158425 | 3676 | 79582242 |
Systolic anterior motion of mitral valve | 43.66 | 9.42 | 12 | 158458 | 47 | 79585871 |
Respiratory acidosis | 43.34 | 9.42 | 79 | 158391 | 11121 | 79574797 |
Infusion site rash | 43.30 | 9.42 | 32 | 158438 | 1670 | 79584248 |
Throat tightness | 43.29 | 9.42 | 138 | 158332 | 27769 | 79558149 |
Treatment failure | 43.16 | 9.42 | 183 | 158287 | 170303 | 79415615 |
Ventricular arrhythmia | 42.97 | 9.42 | 69 | 158401 | 8771 | 79577147 |
Mean arterial pressure decreased | 42.94 | 9.42 | 19 | 158451 | 363 | 79585555 |
Purtscher retinopathy | 42.58 | 9.42 | 14 | 158456 | 112 | 79585806 |
Spinal cord infarction | 42.55 | 9.42 | 22 | 158448 | 601 | 79585317 |
Paralysis | 42.46 | 9.42 | 86 | 158384 | 13091 | 79572827 |
Trigemino-cardiac reflex | 42.35 | 9.42 | 17 | 158453 | 252 | 79585666 |
Status asthmaticus | 42.04 | 9.42 | 26 | 158444 | 1008 | 79584910 |
Aqueous fibrin | 41.33 | 9.42 | 14 | 158456 | 124 | 79585794 |
Oedema peripheral | 41.01 | 9.42 | 313 | 158157 | 251975 | 79333943 |
C-reactive protein increased | 40.94 | 9.42 | 126 | 158344 | 128901 | 79457017 |
Orthostatic hypotension | 40.92 | 9.42 | 31 | 158439 | 56133 | 79529785 |
Liver disorder | 40.03 | 9.42 | 51 | 158419 | 72366 | 79513552 |
Psoriasis | 39.99 | 9.42 | 73 | 158397 | 89514 | 79496404 |
Product adhesion issue | 39.77 | 9.42 | 37 | 158433 | 2667 | 79583251 |
Nerve root injury | 39.47 | 9.42 | 10 | 158460 | 26 | 79585892 |
Myocardial ischaemia | 39.41 | 9.42 | 126 | 158344 | 25393 | 79560525 |
Type I hypersensitivity | 39.14 | 9.42 | 46 | 158424 | 4352 | 79581566 |
Cardiac failure congestive | 39.11 | 9.42 | 148 | 158322 | 142254 | 79443664 |
Hyperdynamic left ventricle | 38.83 | 9.42 | 18 | 158452 | 385 | 79585533 |
Pharyngeal oedema | 38.66 | 9.42 | 94 | 158376 | 16178 | 79569740 |
Drug resistance | 38.20 | 9.42 | 18 | 158452 | 42195 | 79543723 |
Migraine | 38.11 | 9.42 | 301 | 158169 | 87192 | 79498726 |
Ventricular hypokinesia | 37.89 | 9.42 | 67 | 158403 | 9212 | 79576706 |
Abdominal pain upper | 37.65 | 9.42 | 275 | 158195 | 223544 | 79362374 |
Laryngeal oedema | 37.55 | 9.42 | 62 | 158408 | 8067 | 79577851 |
Respiratory distress | 37.55 | 9.42 | 221 | 158249 | 58118 | 79527800 |
Eye infection | 37.47 | 9.42 | 77 | 158393 | 11843 | 79574075 |
Peripheral swelling | 37.29 | 9.42 | 349 | 158121 | 269268 | 79316650 |
Delayed recovery from anaesthesia | 37.14 | 9.42 | 29 | 158441 | 1644 | 79584274 |
Blood creatinine increased | 37.09 | 9.42 | 170 | 158300 | 154887 | 79431031 |
Lip swelling | 36.73 | 9.42 | 170 | 158300 | 40741 | 79545177 |
Medical device site laceration | 36.56 | 9.42 | 7 | 158463 | 0 | 79585918 |
Systemic toxicity | 36.21 | 9.42 | 13 | 158457 | 139 | 79585779 |
White blood cell count decreased | 35.83 | 9.42 | 223 | 158247 | 188065 | 79397853 |
Pharyngeal swelling | 35.83 | 9.42 | 59 | 158411 | 7660 | 79578258 |
Blood cholesterol increased | 35.80 | 9.42 | 70 | 158400 | 83650 | 79502268 |
Myopathy toxic | 35.73 | 9.42 | 24 | 158446 | 1074 | 79584844 |
Retinal vasculitis | 35.69 | 9.42 | 26 | 158444 | 1327 | 79584591 |
Anaphylactoid shock | 35.26 | 9.42 | 21 | 158449 | 760 | 79585158 |
Procedural haemorrhage | 35.06 | 9.42 | 45 | 158425 | 4661 | 79581257 |
Bladder prolapse | 34.13 | 9.42 | 26 | 158444 | 1421 | 79584497 |
Inhibitory drug interaction | 33.83 | 9.42 | 43 | 158427 | 4410 | 79581508 |
Injection site hypoaesthesia | 33.71 | 9.42 | 18 | 158452 | 526 | 79585392 |
Chondromalacia | 33.59 | 9.42 | 13 | 158457 | 174 | 79585744 |
Pharyngitis streptococcal | 33.43 | 9.42 | 69 | 158401 | 10645 | 79575273 |
Dermatitis contact | 33.19 | 9.42 | 70 | 158400 | 10963 | 79574955 |
Fear of eating | 33.16 | 9.42 | 17 | 158453 | 456 | 79585462 |
Infusion site discomfort | 32.88 | 9.42 | 25 | 158445 | 1362 | 79584556 |
Death | 32.81 | 9.42 | 866 | 157604 | 565648 | 79020270 |
Abdominal pain | 32.63 | 9.42 | 561 | 157909 | 389008 | 79196910 |
Hepatocellular injury | 32.51 | 9.42 | 28 | 158442 | 47565 | 79538353 |
Anal sphincter atony | 32.26 | 9.42 | 15 | 158455 | 323 | 79585595 |
Jaundice | 32.24 | 9.42 | 35 | 158435 | 53314 | 79532604 |
Uterine hypertonus | 32.15 | 9.42 | 14 | 158456 | 257 | 79585661 |
Phrenic nerve paralysis | 32.14 | 9.42 | 15 | 158455 | 326 | 79585592 |
Gas gangrene | 31.76 | 9.42 | 14 | 158456 | 265 | 79585653 |
Product contamination microbial | 31.56 | 9.42 | 21 | 158449 | 925 | 79584993 |
Meningitis chemical | 31.09 | 9.42 | 13 | 158457 | 215 | 79585703 |
Stomatitis | 31.03 | 9.42 | 168 | 158302 | 146589 | 79439329 |
Corneal reflex decreased | 31.01 | 9.42 | 15 | 158455 | 354 | 79585564 |
Confusional state | 30.98 | 9.42 | 445 | 158025 | 317552 | 79268366 |
Blood lactic acid increased | 30.68 | 9.42 | 74 | 158396 | 12670 | 79573248 |
Melaena | 30.53 | 9.42 | 46 | 158424 | 60844 | 79525074 |
Infusion site irritation | 30.33 | 9.42 | 19 | 158451 | 754 | 79585164 |
Red blood cell sedimentation rate increased | 30.22 | 9.42 | 28 | 158442 | 45914 | 79540004 |
Normal newborn | 30.09 | 9.42 | 52 | 158418 | 7020 | 79578898 |
Pulmonary fibrosis | 30.07 | 9.42 | 26 | 158444 | 44086 | 79541832 |
Glucose tolerance impaired | 30.00 | 9.42 | 56 | 158414 | 8028 | 79577890 |
Peripheral nerve injury | 29.15 | 9.42 | 18 | 158452 | 696 | 79585222 |
Gastrointestinal haemorrhage | 29.12 | 9.42 | 173 | 158297 | 147546 | 79438372 |
Agranulocytosis | 28.96 | 9.42 | 28 | 158442 | 45002 | 79540916 |
Anaphylactoid reaction | 28.69 | 9.42 | 44 | 158426 | 5378 | 79580540 |
Status epilepticus | 28.63 | 9.42 | 112 | 158358 | 24929 | 79560989 |
Oculocardiac reflex | 28.54 | 9.42 | 9 | 158461 | 62 | 79585856 |
Eye inflammation | 28.40 | 9.42 | 48 | 158422 | 6365 | 79579553 |
Pancreatitis acute | 28.40 | 9.42 | 34 | 158436 | 49570 | 79536348 |
Gastroenteritis viral | 28.34 | 9.42 | 111 | 158359 | 24720 | 79561198 |
Platelet aggregation inhibition | 28.30 | 9.42 | 11 | 158459 | 149 | 79585769 |
International normalised ratio increased | 28.12 | 9.42 | 81 | 158389 | 84640 | 79501278 |
Cytomegalovirus infection | 28.03 | 9.42 | 26 | 158444 | 42618 | 79543300 |
Injection site inflammation | 28.03 | 9.42 | 37 | 158433 | 3939 | 79581979 |
Constipation | 27.95 | 9.42 | 395 | 158075 | 282655 | 79303263 |
Anal inflammation | 27.94 | 9.42 | 23 | 158447 | 1407 | 79584511 |
Irritable bowel syndrome | 27.52 | 9.42 | 51 | 158419 | 62190 | 79523728 |
Liver function test abnormal | 27.49 | 9.42 | 54 | 158416 | 64421 | 79521497 |
Liquid product physical issue | 27.48 | 9.42 | 21 | 158449 | 1153 | 79584765 |
Obesity | 27.42 | 9.42 | 18 | 158452 | 35107 | 79550811 |
Blister | 27.39 | 9.42 | 133 | 158337 | 119343 | 79466575 |
Troponin I increased | 27.28 | 9.42 | 40 | 158430 | 4698 | 79581220 |
Cardiotoxicity | 27.28 | 9.42 | 69 | 158401 | 12170 | 79573748 |
Neuromuscular blockade | 27.24 | 9.42 | 16 | 158454 | 564 | 79585354 |
Tracheal deviation | 26.99 | 9.42 | 11 | 158459 | 170 | 79585748 |
Drug-induced liver injury | 26.81 | 9.42 | 57 | 158413 | 66060 | 79519858 |
Inflammation | 26.68 | 9.42 | 96 | 158374 | 93657 | 79492261 |
Pupil fixed | 26.41 | 9.42 | 34 | 158436 | 3532 | 79582386 |
Ischaemia | 26.37 | 9.42 | 53 | 158417 | 8022 | 79577896 |
Food allergy | 26.22 | 9.42 | 63 | 158407 | 10761 | 79575157 |
Coronary artery disease | 26.08 | 9.42 | 57 | 158413 | 65417 | 79520501 |
Prescribed underdose | 26.07 | 9.42 | 13 | 158457 | 29501 | 79556417 |
Infusion site nodule | 26.05 | 9.42 | 13 | 158457 | 329 | 79585589 |
Blood pH decreased | 26.02 | 9.42 | 39 | 158431 | 4672 | 79581246 |
Vasospasm | 25.92 | 9.42 | 20 | 158450 | 1114 | 79584804 |
Upper airway obstruction | 25.90 | 9.42 | 22 | 158448 | 1406 | 79584512 |
Supraventricular tachycardia | 25.85 | 9.42 | 97 | 158373 | 21173 | 79564745 |
Hypercalcaemia | 25.78 | 9.42 | 23 | 158447 | 38407 | 79547511 |
Hypoglycaemia | 25.73 | 9.42 | 109 | 158361 | 101485 | 79484433 |
Injection site pain | 25.57 | 9.42 | 381 | 158089 | 129457 | 79456461 |
Hepatotoxicity | 25.55 | 9.42 | 39 | 158431 | 51313 | 79534605 |
Paraesthesia oral | 25.42 | 9.42 | 94 | 158376 | 20377 | 79565541 |
Visual acuity reduced | 25.39 | 9.42 | 121 | 158349 | 29348 | 79556570 |
Catarrh | 24.95 | 9.42 | 26 | 158444 | 2152 | 79583766 |
Electrocardiogram T wave inversion | 24.85 | 9.42 | 41 | 158429 | 5331 | 79580587 |
Blindness | 24.78 | 9.42 | 117 | 158353 | 28266 | 79557652 |
Extremity necrosis | 24.77 | 9.42 | 31 | 158439 | 3130 | 79582788 |
Harlequin syndrome | 24.67 | 9.42 | 8 | 158462 | 61 | 79585857 |
Rhinitis | 24.61 | 9.42 | 75 | 158395 | 14732 | 79571186 |
Spinal stroke | 24.60 | 9.42 | 7 | 158463 | 32 | 79585886 |
Hip arthroplasty | 24.47 | 9.42 | 21 | 158449 | 35735 | 79550183 |
Axillary nerve injury | 24.45 | 9.42 | 6 | 158464 | 13 | 79585905 |
Coagulation factor deficiency | 24.45 | 9.42 | 10 | 158460 | 156 | 79585762 |
Fatigue | 24.42 | 9.42 | 1557 | 156913 | 928170 | 78657748 |
Nystagmus | 24.37 | 9.42 | 58 | 158412 | 9846 | 79576072 |
Chemical burn | 24.34 | 9.42 | 15 | 158455 | 578 | 79585340 |
Spinal cord oedema | 24.28 | 9.42 | 13 | 158457 | 382 | 79585536 |
Spinal anaesthesia | 24.23 | 9.42 | 8 | 158462 | 65 | 79585853 |
Metastases to liver | 24.23 | 9.42 | 13 | 158457 | 28301 | 79557617 |
Coma | 24.16 | 9.42 | 306 | 158164 | 100343 | 79485575 |
Inappropriate antidiuretic hormone secretion | 24.15 | 9.42 | 11 | 158459 | 26302 | 79559616 |
Accelerated idioventricular rhythm | 24.13 | 9.42 | 11 | 158459 | 226 | 79585692 |
Corneal epithelium defect | 24.08 | 9.42 | 16 | 158454 | 703 | 79585215 |
Arthritis bacterial | 24.00 | 9.42 | 55 | 158415 | 9111 | 79576807 |
Immunisation reaction | 23.98 | 9.42 | 14 | 158456 | 488 | 79585430 |
Inappropriate schedule of product administration | 23.97 | 9.42 | 386 | 158084 | 133242 | 79452676 |
Familial periodic paralysis | 23.94 | 9.42 | 10 | 158460 | 165 | 79585753 |
Product preparation error | 23.88 | 9.42 | 42 | 158428 | 5751 | 79580167 |
Dry gangrene | 23.83 | 9.42 | 18 | 158452 | 971 | 79584947 |
Hypopnoea | 23.75 | 9.42 | 40 | 158430 | 5289 | 79580629 |
Device ineffective | 23.72 | 9.42 | 10 | 158460 | 169 | 79585749 |
Skin infection | 23.69 | 9.42 | 85 | 158385 | 18160 | 79567758 |
Administration site swelling | 23.65 | 9.42 | 14 | 158456 | 501 | 79585417 |
Adverse event | 23.51 | 9.42 | 53 | 158417 | 60161 | 79525757 |
Haematochezia | 23.47 | 9.42 | 92 | 158378 | 87553 | 79498365 |
Disease recurrence | 23.42 | 9.42 | 32 | 158438 | 44077 | 79541841 |
Factor V Leiden mutation | 23.19 | 9.42 | 10 | 158460 | 179 | 79585739 |
Product use in unapproved indication | 23 | 9.42 | 656 | 157814 | 249703 | 79336215 |
Swelling | 22.98 | 9.42 | 298 | 158172 | 216413 | 79369505 |
PCO2 increased | 22.95 | 9.42 | 23 | 158447 | 1817 | 79584101 |
Musculoskeletal pain | 22.85 | 9.42 | 115 | 158355 | 102239 | 79483679 |
Headache | 22.81 | 9.42 | 1549 | 156921 | 652223 | 78933695 |
Hypercapnia | 22.72 | 9.42 | 53 | 158417 | 8882 | 79577036 |
Gastrointestinal disorder | 22.59 | 9.42 | 146 | 158324 | 122059 | 79463859 |
Burns second degree | 22.58 | 9.42 | 27 | 158443 | 2601 | 79583317 |
Steroid dependence | 22.57 | 9.42 | 27 | 158443 | 2603 | 79583315 |
Urinary tract infection | 22.45 | 9.42 | 709 | 157761 | 273803 | 79312115 |
Myocardial stunning | 22.41 | 9.42 | 10 | 158460 | 195 | 79585723 |
Platelet count decreased | 22.41 | 9.42 | 263 | 158207 | 194401 | 79391517 |
Weight increased | 22.39 | 9.42 | 402 | 158068 | 276984 | 79308934 |
Haemoglobin decreased | 22.26 | 9.42 | 309 | 158161 | 221810 | 79364108 |
Hypercholesterolaemia | 22.24 | 9.42 | 9 | 158461 | 23086 | 79562832 |
Prostate cancer | 22.21 | 9.42 | 20 | 158450 | 33248 | 79552670 |
Atrioventricular block complete | 22.09 | 9.42 | 78 | 158392 | 16532 | 79569386 |
Product administration error | 22.03 | 9.42 | 123 | 158347 | 31723 | 79554195 |
Rheumatoid nodule | 22.02 | 9.42 | 4 | 158466 | 17434 | 79568484 |
Abortion spontaneous | 21.86 | 9.42 | 16 | 158454 | 29491 | 79556427 |
Scar | 21.64 | 9.42 | 73 | 158397 | 15123 | 79570795 |
PO2 decreased | 21.55 | 9.42 | 28 | 158442 | 2935 | 79582983 |
Vasoconstriction | 21.49 | 9.42 | 15 | 158455 | 715 | 79585203 |
Product prescribing error | 21.38 | 9.42 | 35 | 158435 | 44778 | 79541140 |
Osteonecrosis of jaw | 21.34 | 9.42 | 33 | 158437 | 43193 | 79542725 |
Gait inability | 21.30 | 9.42 | 54 | 158416 | 58863 | 79527055 |
Eyelid ptosis | 21.30 | 9.42 | 59 | 158411 | 10985 | 79574933 |
Hepatitis | 21.00 | 9.42 | 50 | 158420 | 55677 | 79530241 |
Balance disorder | 20.98 | 9.42 | 113 | 158357 | 98744 | 79487174 |
Lung hyperinflation | 20.95 | 9.42 | 22 | 158448 | 1837 | 79584081 |
Fear of death | 20.87 | 9.42 | 20 | 158450 | 1496 | 79584422 |
Creatinine renal clearance decreased | 20.73 | 9.42 | 6 | 158464 | 18996 | 79566922 |
SARS-CoV-2 test negative | 20.63 | 9.42 | 19 | 158451 | 1352 | 79584566 |
Kidney infection | 20.50 | 9.42 | 92 | 158378 | 21759 | 79564159 |
Quadriplegia | 20.27 | 9.42 | 29 | 158441 | 3331 | 79582587 |
Alanine aminotransferase increased | 20.14 | 9.42 | 216 | 158254 | 162354 | 79423564 |
Chills | 20.12 | 9.42 | 438 | 158032 | 159796 | 79426122 |
Impaired work ability | 20.10 | 9.42 | 85 | 158385 | 19596 | 79566322 |
Poor quality sleep | 20.08 | 9.42 | 94 | 158376 | 22628 | 79563290 |
Pneumocystis jirovecii pneumonia | 20.01 | 9.42 | 21 | 158449 | 32487 | 79553431 |
Pneumocephalus | 19.95 | 9.42 | 11 | 158459 | 343 | 79585575 |
Sensory loss | 19.93 | 9.42 | 64 | 158406 | 12927 | 79572991 |
Sinus disorder | 19.91 | 9.42 | 93 | 158377 | 22371 | 79563547 |
Progressive multifocal leukoencephalopathy | 19.88 | 9.42 | 8 | 158462 | 20592 | 79565326 |
Gamma-glutamyltransferase increased | 19.86 | 9.42 | 50 | 158420 | 54630 | 79531288 |
Compartment syndrome | 19.86 | 9.42 | 36 | 158434 | 5046 | 79580872 |
Brain oedema | 19.82 | 9.42 | 101 | 158369 | 25162 | 79560756 |
Propofol infusion syndrome | 19.78 | 9.42 | 22 | 158448 | 1961 | 79583957 |
Respiratory failure | 19.77 | 9.42 | 485 | 157985 | 180426 | 79405492 |
Neoplasm progression | 19.77 | 9.42 | 46 | 158424 | 51636 | 79534282 |
Rectal prolapse | 19.75 | 9.42 | 23 | 158447 | 2155 | 79583763 |
Ill-defined disorder | 19.72 | 9.42 | 66 | 158404 | 65809 | 79520109 |
Diabetes mellitus inadequate control | 19.53 | 9.42 | 12 | 158458 | 24252 | 79561666 |
Nerve block | 19.49 | 9.42 | 14 | 158456 | 699 | 79585219 |
Bursitis infective | 19.48 | 9.42 | 18 | 158452 | 1286 | 79584632 |
Weight decreased | 19.47 | 9.42 | 547 | 157923 | 354651 | 79231267 |
Reversible cerebral vasoconstriction syndrome | 19.35 | 9.42 | 27 | 158443 | 3030 | 79582888 |
Dehydration | 19.30 | 9.42 | 362 | 158108 | 247825 | 79338093 |
Sinus bradycardia | 19.15 | 9.42 | 100 | 158370 | 25147 | 79560771 |
Atonic urinary bladder | 19.08 | 9.42 | 7 | 158463 | 80 | 79585838 |
No adverse event | 19.06 | 9.42 | 133 | 158337 | 37059 | 79548859 |
Foreign body | 18.98 | 9.42 | 26 | 158444 | 2868 | 79583050 |
Oral herpes | 18.97 | 9.42 | 106 | 158364 | 27348 | 79558570 |
Respiratory tract infection bacterial | 18.94 | 9.42 | 22 | 158448 | 2055 | 79583863 |
Distributive shock | 18.93 | 9.42 | 25 | 158445 | 2662 | 79583256 |
Staphylococcal infection | 18.89 | 9.42 | 188 | 158282 | 58107 | 79527811 |
Diabetic ketoacidosis | 18.89 | 9.42 | 24 | 158446 | 34098 | 79551820 |
Gastroenteritis | 18.84 | 9.42 | 24 | 158446 | 34058 | 79551860 |
Treatment noncompliance | 18.83 | 9.42 | 48 | 158422 | 52220 | 79533698 |
Brain injury | 18.82 | 9.42 | 58 | 158412 | 11459 | 79574459 |
Parophthalmia | 18.77 | 9.42 | 11 | 158459 | 386 | 79585532 |
SARS-CoV-2 test false positive | 18.66 | 9.42 | 4 | 158466 | 3 | 79585915 |
Suicide attempt | 18.61 | 9.42 | 93 | 158377 | 82839 | 79503079 |
Schizophrenia | 18.54 | 9.42 | 4 | 158466 | 15436 | 79570482 |
Respiratory arrest | 18.36 | 9.42 | 185 | 158285 | 57365 | 79528553 |
Intracranial hypotension | 18.30 | 9.42 | 11 | 158459 | 405 | 79585513 |
Glossoptosis | 18.24 | 9.42 | 9 | 158461 | 222 | 79585696 |
Product administered at inappropriate site | 17.99 | 9.42 | 30 | 158440 | 3935 | 79581983 |
Arterial spasm | 17.93 | 9.42 | 8 | 158462 | 156 | 79585762 |
Foot deformity | 17.91 | 9.42 | 13 | 158457 | 24061 | 79561857 |
Apnoeic attack | 17.89 | 9.42 | 13 | 158457 | 661 | 79585257 |
Hepatic cirrhosis | 17.86 | 9.42 | 26 | 158444 | 34880 | 79551038 |
Premature delivery | 17.84 | 9.42 | 93 | 158377 | 23374 | 79562544 |
Myelosuppression | 17.83 | 9.42 | 33 | 158437 | 40263 | 79545655 |
Cardio-respiratory arrest | 17.83 | 9.42 | 309 | 158161 | 108201 | 79477717 |
Graft versus host disease | 17.82 | 9.42 | 4 | 158466 | 15022 | 79570896 |
Transient ischaemic attack | 17.76 | 9.42 | 50 | 158420 | 52645 | 79533273 |
Cognitive disorder | 17.72 | 9.42 | 75 | 158395 | 69851 | 79516067 |
Palmar-plantar erythrodysaesthesia syndrome | 17.63 | 9.42 | 24 | 158446 | 33110 | 79552808 |
Administration site pain | 17.61 | 9.42 | 12 | 158458 | 550 | 79585368 |
Discomfort | 17.61 | 9.42 | 162 | 158308 | 125455 | 79460463 |
Punctate keratitis | 17.49 | 9.42 | 15 | 158455 | 971 | 79584947 |
Pupillary reflex impaired | 17.44 | 9.42 | 27 | 158443 | 3326 | 79582592 |
Pancreatic carcinoma | 17.39 | 9.42 | 3 | 158467 | 13574 | 79572344 |
Neutropenic sepsis | 17.21 | 9.42 | 17 | 158453 | 27047 | 79558871 |
Coagulation factor V level abnormal | 17.16 | 9.42 | 6 | 158464 | 59 | 79585859 |
Eyelid oedema | 17.12 | 9.42 | 63 | 158407 | 13624 | 79572294 |
Depressed mood | 17.09 | 9.42 | 45 | 158425 | 48435 | 79537483 |
Lung neoplasm malignant | 17.05 | 9.42 | 18 | 158452 | 27774 | 79558144 |
Postoperative delirium | 17.01 | 9.42 | 10 | 158460 | 353 | 79585565 |
Device infusion issue | 16.95 | 9.42 | 22 | 158448 | 2304 | 79583614 |
Oxygen saturation decreased | 16.92 | 9.42 | 355 | 158115 | 128692 | 79457226 |
Chest discomfort | 16.90 | 9.42 | 376 | 158094 | 137668 | 79448250 |
Bone marrow failure | 16.86 | 9.42 | 49 | 158421 | 51058 | 79534860 |
Streptococcal infection | 16.86 | 9.42 | 47 | 158423 | 8783 | 79577135 |
Neuroleptic malignant syndrome | 16.74 | 9.42 | 18 | 158452 | 27541 | 79558377 |
Diabetes insipidus | 16.66 | 9.42 | 34 | 158436 | 5203 | 79580715 |
Wheezing | 16.65 | 9.42 | 325 | 158145 | 116339 | 79469579 |
Monoplegia | 16.64 | 9.42 | 29 | 158441 | 3942 | 79581976 |
Vitamin D increased | 16.60 | 9.42 | 12 | 158458 | 605 | 79585313 |
Limb injury | 16.57 | 9.42 | 108 | 158362 | 29420 | 79556498 |
Neurotoxicity | 16.50 | 9.42 | 116 | 158354 | 32402 | 79553516 |
Heart rate increased | 16.45 | 9.42 | 334 | 158136 | 120390 | 79465528 |
Diabetes mellitus | 16.42 | 9.42 | 90 | 158380 | 78300 | 79507618 |
Brain stem syndrome | 16.22 | 9.42 | 14 | 158456 | 914 | 79585004 |
Postpartum disorder | 16.20 | 9.42 | 4 | 158466 | 9 | 79585909 |
Epinephrine increased | 16.20 | 9.42 | 4 | 158466 | 9 | 79585909 |
Injection site joint infection | 16.17 | 9.42 | 5 | 158465 | 32 | 79585886 |
Irregular breathing | 16.09 | 9.42 | 11 | 158459 | 507 | 79585411 |
Rotator cuff syndrome | 16.08 | 9.42 | 63 | 158407 | 14032 | 79571886 |
Blood creatine phosphokinase increased | 16.07 | 9.42 | 72 | 158398 | 66018 | 79519900 |
Gait disturbance | 16.02 | 9.42 | 303 | 158167 | 207203 | 79378715 |
Sinus arrest | 15.90 | 9.42 | 27 | 158443 | 3595 | 79582323 |
Aplastic anaemia | 15.77 | 9.42 | 74 | 158396 | 17831 | 79568087 |
Poor quality product administered | 15.77 | 9.42 | 27 | 158443 | 3618 | 79582300 |
Blood pressure increased | 15.75 | 9.42 | 540 | 157930 | 210820 | 79375098 |
Product use issue | 15.71 | 9.42 | 308 | 158162 | 209514 | 79376404 |
Drug abuse | 15.70 | 9.42 | 228 | 158242 | 162463 | 79423455 |
Application site pallor | 15.67 | 9.42 | 3 | 158467 | 0 | 79585918 |
Hypercatabolism | 15.67 | 9.42 | 3 | 158467 | 0 | 79585918 |
Airway complication of anaesthesia | 15.67 | 9.42 | 10 | 158460 | 410 | 79585508 |
Peripheral venous disease | 15.65 | 9.42 | 6 | 158464 | 15903 | 79570015 |
Injection site discharge | 15.60 | 9.42 | 13 | 158457 | 809 | 79585109 |
Nasal discharge discolouration | 15.56 | 9.42 | 22 | 158448 | 2499 | 79583419 |
Vocal cord disorder | 15.52 | 9.42 | 17 | 158453 | 1489 | 79584429 |
Dental restoration failure | 15.51 | 9.42 | 14 | 158456 | 970 | 79584948 |
Infusion site reaction | 15.28 | 9.42 | 26 | 158444 | 3467 | 79582451 |
Poor venous access | 15.26 | 9.42 | 74 | 158396 | 18075 | 79567843 |
Skin test positive | 15.25 | 9.42 | 15 | 158455 | 1159 | 79584759 |
Peritonitis | 15.23 | 9.42 | 20 | 158450 | 28016 | 79557902 |
Spinal epidural haemorrhage | 15.22 | 9.42 | 7 | 158463 | 147 | 79585771 |
Respiratory tract infection viral | 15.18 | 9.42 | 29 | 158441 | 4230 | 79581688 |
Macroglossia | 15.17 | 9.42 | 15 | 158455 | 1166 | 79584752 |
Application site alopecia | 15.13 | 9.42 | 4 | 158466 | 13 | 79585905 |
Amaurosis | 15.07 | 9.42 | 15 | 158455 | 1176 | 79584742 |
Phaeochromocytoma crisis | 15.05 | 9.42 | 9 | 158461 | 328 | 79585590 |
Muscle tightness | 14.96 | 9.42 | 58 | 158412 | 12856 | 79573062 |
Acute pulmonary oedema | 14.95 | 9.42 | 62 | 158408 | 14168 | 79571750 |
Lip dry | 14.86 | 9.42 | 6 | 158464 | 15412 | 79570506 |
Fall | 14.83 | 9.42 | 805 | 157665 | 486824 | 79099094 |
Postresuscitation encephalopathy | 14.69 | 9.42 | 5 | 158465 | 45 | 79585873 |
Diplegia | 14.64 | 9.42 | 18 | 158452 | 1785 | 79584133 |
Knee arthroplasty | 14.61 | 9.42 | 41 | 158429 | 43207 | 79542711 |
Eosinophilia | 14.58 | 9.42 | 44 | 158426 | 45301 | 79540617 |
Urticaria chronic | 14.54 | 9.42 | 11 | 158459 | 595 | 79585323 |
Retinal vascular occlusion | 14.52 | 9.42 | 11 | 158459 | 596 | 79585322 |
Infusion site scar | 14.44 | 9.42 | 9 | 158461 | 354 | 79585564 |
Capillary nail refill test abnormal | 14.41 | 9.42 | 5 | 158465 | 48 | 79585870 |
Skin ulcer | 14.40 | 9.42 | 57 | 158413 | 54093 | 79531825 |
ECG signs of myocardial ischaemia | 14.37 | 9.42 | 9 | 158461 | 357 | 79585561 |
Hallucination, auditory | 14.35 | 9.42 | 12 | 158458 | 20681 | 79565237 |
Drug tolerance decreased | 14.34 | 9.42 | 4 | 158466 | 12974 | 79572944 |
Catecholamine crisis | 14.32 | 9.42 | 5 | 158465 | 49 | 79585869 |
Torsade de pointes | 14.31 | 9.42 | 76 | 158394 | 19236 | 79566682 |
Epidural analgesia | 14.23 | 9.42 | 5 | 158465 | 50 | 79585868 |
Heparin-induced thrombocytopenia | 14.22 | 9.42 | 47 | 158423 | 9635 | 79576283 |
Seizure like phenomena | 14.14 | 9.42 | 18 | 158452 | 1849 | 79584069 |
Blood pressure fluctuation | 14.11 | 9.42 | 77 | 158393 | 67068 | 79518850 |
Anion gap increased | 14.09 | 9.42 | 26 | 158444 | 3694 | 79582224 |
Pneumonia mycoplasmal | 14.06 | 9.42 | 16 | 158454 | 1462 | 79584456 |
Parosmia | 14.05 | 9.42 | 38 | 158432 | 6976 | 79578942 |
Angina pectoris | 14.04 | 9.42 | 54 | 158416 | 51678 | 79534240 |
Hypomagnesaemia | 14.04 | 9.42 | 47 | 158423 | 46864 | 79539054 |
Hepatitis cholestatic | 14 | 9.42 | 5 | 158465 | 13847 | 79572071 |
Accident | 14.00 | 9.42 | 44 | 158426 | 8787 | 79577131 |
Immune reconstitution inflammatory syndrome | 13.98 | 9.42 | 5 | 158465 | 13836 | 79572082 |
Laryngospasm | 13.98 | 9.42 | 27 | 158443 | 3970 | 79581948 |
Bladder cancer | 13.94 | 9.42 | 11 | 158459 | 19515 | 79566403 |
SARS-CoV-2 test positive | 13.88 | 9.42 | 53 | 158417 | 11663 | 79574255 |
Neurogenic shock | 13.85 | 9.42 | 11 | 158459 | 639 | 79585279 |
Arthritis infective | 13.84 | 9.42 | 42 | 158428 | 8229 | 79577689 |
Incision site rash | 13.77 | 9.42 | 4 | 158466 | 20 | 79585898 |
Trigeminal palsy | 13.77 | 9.42 | 4 | 158466 | 20 | 79585898 |
Tracheitis | 13.70 | 9.42 | 15 | 158455 | 1313 | 79584605 |
Hallucination | 13.62 | 9.42 | 107 | 158363 | 85638 | 79500280 |
Meningitis | 13.62 | 9.42 | 46 | 158424 | 9536 | 79576382 |
Caffeine allergy | 13.60 | 9.42 | 4 | 158466 | 21 | 79585897 |
Implant site bruising | 13.60 | 9.42 | 8 | 158462 | 283 | 79585635 |
Nerve root injury cervical | 13.60 | 9.42 | 3 | 158467 | 3 | 79585915 |
Removal of foreign body from throat | 13.60 | 9.42 | 3 | 158467 | 3 | 79585915 |
Ascites | 13.59 | 9.42 | 91 | 158379 | 75471 | 79510447 |
Cranial nerve palsies multiple | 13.59 | 9.42 | 6 | 158464 | 114 | 79585804 |
Viral infection | 13.59 | 9.42 | 138 | 158332 | 42878 | 79543040 |
Blindness cortical | 13.55 | 9.42 | 13 | 158457 | 974 | 79584944 |
Enzyme induction | 13.54 | 9.42 | 6 | 158464 | 115 | 79585803 |
Lymphopenia | 13.54 | 9.42 | 25 | 158445 | 30532 | 79555386 |
Oropharyngeal discomfort | 13.54 | 9.42 | 38 | 158432 | 7128 | 79578790 |
Cholestasis of pregnancy | 13.48 | 9.42 | 13 | 158457 | 980 | 79584938 |
Ventricular tachyarrhythmia | 13.43 | 9.42 | 9 | 158461 | 401 | 79585517 |
Anion gap | 13.42 | 9.42 | 19 | 158451 | 2162 | 79583756 |
Mental status changes | 13.38 | 9.42 | 197 | 158273 | 66762 | 79519156 |
Hyperkalaemia | 13.37 | 9.42 | 154 | 158316 | 114244 | 79471674 |
Haematuria | 13.36 | 9.42 | 81 | 158389 | 68755 | 79517163 |
Nail bed tenderness | 13.35 | 9.42 | 9 | 158461 | 405 | 79585513 |
Polyneuropathy | 13.35 | 9.42 | 17 | 158453 | 24134 | 79561784 |
Drug level decreased | 13.25 | 9.42 | 6 | 158464 | 14396 | 79571522 |
Product distribution issue | 13.23 | 9.42 | 15 | 158455 | 1365 | 79584553 |
Proteinuria | 13.19 | 9.42 | 28 | 158442 | 32474 | 79553444 |
Hepatic function abnormal | 13.17 | 9.42 | 88 | 158382 | 73019 | 79512899 |
Condition aggravated | 13.14 | 9.42 | 839 | 157631 | 500285 | 79085633 |
Atrophy of globe | 13.12 | 9.42 | 5 | 158465 | 64 | 79585854 |
Haemorrhoids | 13.12 | 9.42 | 101 | 158369 | 29027 | 79556891 |
Renal cancer | 13.08 | 9.42 | 4 | 158466 | 12222 | 79573696 |
Polyarthritis | 13.04 | 9.42 | 4 | 158466 | 12198 | 79573720 |
Pupillary light reflex tests abnormal | 13.01 | 9.42 | 8 | 158462 | 307 | 79585611 |
Myopathy | 12.98 | 9.42 | 13 | 158457 | 20550 | 79565368 |
Product preparation issue | 12.97 | 9.42 | 15 | 158455 | 1395 | 79584523 |
Vaccination complication | 12.94 | 9.42 | 12 | 158458 | 861 | 79585057 |
Cardiac failure | 12.93 | 9.42 | 223 | 158247 | 154619 | 79431299 |
Laryngeal obstruction | 12.91 | 9.42 | 6 | 158464 | 129 | 79585789 |
Brown-Sequard syndrome | 12.91 | 9.42 | 5 | 158465 | 67 | 79585851 |
Mast cell activation syndrome | 12.87 | 9.42 | 11 | 158459 | 709 | 79585209 |
Joint stiffness | 12.85 | 9.42 | 40 | 158430 | 40790 | 79545128 |
Loss of personal independence in daily activities | 12.82 | 9.42 | 136 | 158334 | 102444 | 79483474 |
Disseminated intravascular coagulation | 12.80 | 9.42 | 118 | 158352 | 35724 | 79550194 |
Cardiopulmonary failure | 12.79 | 9.42 | 36 | 158434 | 6765 | 79579153 |
Therapeutic product effect prolonged | 12.77 | 9.42 | 10 | 158460 | 569 | 79585349 |
Air embolism | 12.73 | 9.42 | 9 | 158461 | 438 | 79585480 |
Vascular resistance systemic decreased | 12.70 | 9.42 | 7 | 158463 | 218 | 79585700 |
Procedural pain | 12.69 | 9.42 | 84 | 158386 | 23000 | 79562918 |
Myocardial necrosis marker increased | 12.69 | 9.42 | 23 | 158447 | 3223 | 79582695 |
Myocardial infarction | 12.68 | 9.42 | 274 | 158196 | 183855 | 79402063 |
Pharyngitis | 12.66 | 9.42 | 82 | 158388 | 22293 | 79563625 |
Injection site nerve damage | 12.65 | 9.42 | 5 | 158465 | 71 | 79585847 |
Catheter site pain | 12.63 | 9.42 | 31 | 158439 | 5365 | 79580553 |
Neuropathy peripheral | 12.62 | 9.42 | 201 | 158269 | 141104 | 79444814 |
Dermatitis exfoliative | 12.61 | 9.42 | 3 | 158467 | 10826 | 79575092 |
Inability to afford medication | 12.61 | 9.42 | 21 | 158449 | 2752 | 79583166 |
Paranasal cyst | 12.59 | 9.42 | 9 | 158461 | 446 | 79585472 |
Insomnia | 12.56 | 9.42 | 381 | 158089 | 244789 | 79341129 |
Exposure during pregnancy | 12.55 | 9.42 | 276 | 158194 | 100856 | 79485062 |
Oxidative stress | 12.51 | 9.42 | 4 | 158466 | 29 | 79585889 |
Anaesthetic complication cardiac | 12.40 | 9.42 | 5 | 158465 | 75 | 79585843 |
Injection site necrosis | 12.40 | 9.42 | 15 | 158455 | 1463 | 79584455 |
Eye infection intraocular | 12.39 | 9.42 | 4 | 158466 | 30 | 79585888 |
Forced vital capacity abnormal | 12.39 | 9.42 | 4 | 158466 | 30 | 79585888 |
Myelodysplastic syndrome | 12.38 | 9.42 | 26 | 158444 | 30275 | 79555643 |
Device malfunction | 12.38 | 9.42 | 79 | 158391 | 21369 | 79564549 |
Hypocalcaemia | 12.37 | 9.42 | 54 | 158416 | 49870 | 79536048 |
Inadequate analgesia | 12.37 | 9.42 | 28 | 158442 | 4601 | 79581317 |
Autonomic nervous system imbalance | 12.36 | 9.42 | 28 | 158442 | 4602 | 79581316 |
Sedation | 12.34 | 9.42 | 57 | 158413 | 51838 | 79534080 |
Blood alkaline phosphatase increased | 12.31 | 9.42 | 75 | 158395 | 63589 | 79522329 |
Post lumbar puncture syndrome | 12.29 | 9.42 | 11 | 158459 | 754 | 79585164 |
Infection | 12.29 | 9.42 | 376 | 158094 | 241336 | 79344582 |
Bradyphrenia | 12.29 | 9.42 | 3 | 158467 | 10637 | 79575281 |
Procedural anxiety | 12.28 | 9.42 | 11 | 158459 | 755 | 79585163 |
Left ventricular dysfunction | 12.23 | 9.42 | 73 | 158397 | 19288 | 79566630 |
Allergic reaction to excipient | 12.19 | 9.42 | 8 | 158462 | 344 | 79585574 |
Retinal haemorrhage | 12.17 | 9.42 | 40 | 158430 | 8177 | 79577741 |
Mania | 12.16 | 9.42 | 11 | 158459 | 18249 | 79567669 |
Optic atrophy | 12.13 | 9.42 | 17 | 158453 | 1916 | 79584002 |
Dry mouth | 12.12 | 9.42 | 114 | 158356 | 87905 | 79498013 |
Fluid retention | 12.10 | 9.42 | 85 | 158385 | 69724 | 79516194 |
Tenosynovitis | 12.10 | 9.42 | 8 | 158462 | 15546 | 79570372 |
Hepatic cancer | 12.10 | 9.42 | 3 | 158467 | 10526 | 79575392 |
Optic nerve injury | 12.09 | 9.42 | 10 | 158460 | 616 | 79585302 |
Intentional product use issue | 12.09 | 9.42 | 221 | 158249 | 151891 | 79434027 |
Enthesopathy | 12.06 | 9.42 | 4 | 158466 | 11604 | 79574314 |
Osteoarthritis | 12.06 | 9.42 | 113 | 158357 | 87196 | 79498722 |
Long QT syndrome congenital | 12.05 | 9.42 | 6 | 158464 | 151 | 79585767 |
Exophthalmos | 12.04 | 9.42 | 16 | 158454 | 1714 | 79584204 |
Pain in jaw | 12.00 | 9.42 | 49 | 158421 | 46102 | 79539816 |
Nodal rhythm | 11.99 | 9.42 | 22 | 158448 | 3113 | 79582805 |
Abnormal behaviour | 11.95 | 9.42 | 35 | 158435 | 36386 | 79549532 |
Pallor | 11.92 | 9.42 | 152 | 158318 | 49910 | 79536008 |
Hypophagia | 11.91 | 9.42 | 48 | 158422 | 45319 | 79540599 |
Tooth infection | 11.89 | 9.42 | 71 | 158399 | 18761 | 79567157 |
Ocular retrobulbar haemorrhage | 11.87 | 9.42 | 6 | 158464 | 156 | 79585762 |
Central venous catheter removal | 11.84 | 9.42 | 9 | 158461 | 490 | 79585428 |
Injury corneal | 11.83 | 9.42 | 5 | 158465 | 85 | 79585833 |
Post transplant lymphoproliferative disorder | 11.82 | 9.42 | 4 | 158466 | 11460 | 79574458 |
Breast cancer female | 11.82 | 9.42 | 4 | 158466 | 11457 | 79574461 |
Conjunctival oedema | 11.81 | 9.42 | 13 | 158457 | 1145 | 79584773 |
Oral pruritus | 11.75 | 9.42 | 19 | 158451 | 2429 | 79583489 |
Vitreous disorder | 11.74 | 9.42 | 7 | 158463 | 254 | 79585664 |
Mucosal inflammation | 11.69 | 9.42 | 95 | 158375 | 75485 | 79510433 |
Second primary malignancy | 11.69 | 9.42 | 7 | 158463 | 14343 | 79571575 |
Lung disorder | 11.68 | 9.42 | 103 | 158367 | 80454 | 79505464 |
Thermal burn | 11.65 | 9.42 | 36 | 158434 | 7124 | 79578794 |
Cardiac assistance device user | 11.62 | 9.42 | 5 | 158465 | 89 | 79585829 |
Panniculitis | 11.62 | 9.42 | 5 | 158465 | 12366 | 79573552 |
Rhabdomyolysis | 11.60 | 9.42 | 140 | 158330 | 102991 | 79482927 |
Pain in extremity | 11.59 | 9.42 | 599 | 157871 | 363939 | 79221979 |
Tuberculosis | 11.58 | 9.42 | 8 | 158462 | 15190 | 79570728 |
Foetal heart rate abnormal | 11.56 | 9.42 | 8 | 158462 | 376 | 79585542 |
Product contamination physical | 11.53 | 9.42 | 6 | 158464 | 166 | 79585752 |
Therapeutic product effect incomplete | 11.50 | 9.42 | 205 | 158265 | 141440 | 79444478 |
Injection site scar | 11.49 | 9.42 | 11 | 158459 | 822 | 79585096 |
Grip strength decreased | 11.47 | 9.42 | 16 | 158454 | 21853 | 79564065 |
Intentional product misuse to child | 11.47 | 9.42 | 5 | 158465 | 92 | 79585826 |
End-tidal CO2 decreased | 11.47 | 9.42 | 4 | 158466 | 39 | 79585879 |
Quadriparesis | 11.46 | 9.42 | 23 | 158447 | 3478 | 79582440 |
Hypoventilation | 11.46 | 9.42 | 36 | 158434 | 7188 | 79578730 |
Erythema | 11.43 | 9.42 | 548 | 157922 | 222742 | 79363176 |
BRASH syndrome | 11.40 | 9.42 | 12 | 158458 | 1005 | 79584913 |
Femoral nerve injury | 11.38 | 9.42 | 4 | 158466 | 40 | 79585878 |
Fungal infection | 11.36 | 9.42 | 130 | 158340 | 41618 | 79544300 |
Immunodeficiency | 11.35 | 9.42 | 16 | 158454 | 21752 | 79564166 |
Sinus operation | 11.32 | 9.42 | 19 | 158451 | 2506 | 79583412 |
XIIth nerve injury | 11.29 | 9.42 | 3 | 158467 | 10 | 79585908 |
Rash | 11.23 | 9.42 | 993 | 157477 | 577365 | 79008553 |
Tympanoplasty | 11.21 | 9.42 | 4 | 158466 | 42 | 79585876 |
Intraocular pressure increased | 11.20 | 9.42 | 42 | 158428 | 9163 | 79576755 |
Oesophageal carcinoma | 11.20 | 9.42 | 4 | 158466 | 11080 | 79574838 |
Bundle branch block left | 11.20 | 9.42 | 49 | 158421 | 11464 | 79574454 |
Mastocytosis | 11.18 | 9.42 | 9 | 158461 | 533 | 79585385 |
Foreign body in respiratory tract | 11.18 | 9.42 | 8 | 158462 | 397 | 79585521 |
Opisthotonus | 11.17 | 9.42 | 10 | 158460 | 686 | 79585232 |
Spinal epidural haematoma | 11.15 | 9.42 | 14 | 158456 | 1418 | 79584500 |
Histamine level increased | 11.14 | 9.42 | 5 | 158465 | 99 | 79585819 |
Post-anoxic myoclonus | 11.12 | 9.42 | 4 | 158466 | 43 | 79585875 |
Areflexia | 11.11 | 9.42 | 30 | 158440 | 5504 | 79580414 |
Bronchopulmonary aspergillosis allergic | 11.10 | 9.42 | 21 | 158449 | 3040 | 79582878 |
Allodynia | 11.10 | 9.42 | 15 | 158455 | 1633 | 79584285 |
Corneal abrasion | 11.09 | 9.42 | 13 | 158457 | 1226 | 79584692 |
Infusion site haematoma | 11.08 | 9.42 | 7 | 158463 | 282 | 79585636 |
Splenomegaly | 11.07 | 9.42 | 15 | 158455 | 20739 | 79565179 |
Transaminases increased | 11.06 | 9.42 | 59 | 158411 | 51684 | 79534234 |
Vaginal abscess | 11.05 | 9.42 | 8 | 158462 | 404 | 79585514 |
Respiratory tract oedema | 11.04 | 9.42 | 11 | 158459 | 863 | 79585055 |
Anaphylactoid syndrome of pregnancy | 11.04 | 9.42 | 4 | 158466 | 44 | 79585874 |
Infusion site warmth | 10.97 | 9.42 | 14 | 158456 | 1441 | 79584477 |
Lupus-like syndrome | 10.95 | 9.42 | 7 | 158463 | 13850 | 79572068 |
Product contamination | 10.92 | 9.42 | 13 | 158457 | 1247 | 79584671 |
Injection site atrophy | 10.90 | 9.42 | 8 | 158462 | 413 | 79585505 |
Suicidal ideation | 10.89 | 9.42 | 98 | 158372 | 76242 | 79509676 |
Renal failure | 10.88 | 9.42 | 496 | 157974 | 200472 | 79385446 |
Administration site discolouration | 10.87 | 9.42 | 3 | 158467 | 12 | 79585906 |
Electrocardiogram ST-T segment depression | 10.87 | 9.42 | 3 | 158467 | 12 | 79585906 |
Proctalgia | 10.85 | 9.42 | 44 | 158426 | 9957 | 79575961 |
Reperfusion arrhythmia | 10.84 | 9.42 | 7 | 158463 | 293 | 79585625 |
Orbital oedema | 10.80 | 9.42 | 8 | 158462 | 419 | 79585499 |
Tongue pruritus | 10.79 | 9.42 | 9 | 158461 | 561 | 79585357 |
Chronic kidney disease | 10.77 | 9.42 | 82 | 158388 | 66072 | 79519846 |
Incision site swelling | 10.75 | 9.42 | 7 | 158463 | 297 | 79585621 |
Colour blindness | 10.75 | 9.42 | 8 | 158462 | 422 | 79585496 |
Cholangitis | 10.74 | 9.42 | 6 | 158464 | 12770 | 79573148 |
Device expulsion | 10.73 | 9.42 | 22 | 158448 | 25839 | 79560079 |
Malaise | 10.73 | 9.42 | 833 | 157637 | 489036 | 79096882 |
Autoimmune hepatitis | 10.70 | 9.42 | 5 | 158465 | 11778 | 79574140 |
Colitis microscopic | 10.69 | 9.42 | 4 | 158466 | 10764 | 79575154 |
Victim of spousal abuse | 10.67 | 9.42 | 3 | 158467 | 13 | 79585905 |
Symblepharon | 10.66 | 9.42 | 6 | 158464 | 195 | 79585723 |
Intra-ocular injection complication | 10.65 | 9.42 | 4 | 158466 | 49 | 79585869 |
Inflammatory marker increased | 10.65 | 9.42 | 4 | 158466 | 10736 | 79575182 |
Heliotrope rash | 10.63 | 9.42 | 6 | 158464 | 196 | 79585722 |
Cold urticaria | 10.57 | 9.42 | 5 | 158465 | 112 | 79585806 |
Photosensitivity reaction | 10.55 | 9.42 | 16 | 158454 | 21111 | 79564807 |
Hepatic cytolysis | 10.52 | 9.42 | 24 | 158446 | 27127 | 79558791 |
Product measured potency issue | 10.49 | 9.42 | 6 | 158464 | 201 | 79585717 |
Peritonitis bacterial | 10.47 | 9.42 | 3 | 158467 | 9564 | 79576354 |
Croup infectious | 10.46 | 9.42 | 10 | 158460 | 746 | 79585172 |
Myoclonic epilepsy | 10.44 | 9.42 | 16 | 158454 | 1954 | 79583964 |
Diplopia | 10.40 | 9.42 | 107 | 158363 | 33359 | 79552559 |
Lip disorder | 10.39 | 9.42 | 14 | 158456 | 1520 | 79584398 |
Mouth swelling | 10.38 | 9.42 | 31 | 158439 | 6020 | 79579898 |
Spinal operation | 10.38 | 9.42 | 37 | 158433 | 7880 | 79578038 |
Postural orthostatic tachycardia syndrome | 10.37 | 9.42 | 11 | 158459 | 929 | 79584989 |
Swelling face | 10.37 | 9.42 | 199 | 158271 | 71013 | 79514905 |
Body dysmorphic disorder | 10.33 | 9.42 | 7 | 158463 | 318 | 79585600 |
Coccygectomy | 10.32 | 9.42 | 3 | 158467 | 15 | 79585903 |
Tubulointerstitial nephritis | 10.32 | 9.42 | 40 | 158430 | 38195 | 79547723 |
Infusion site induration | 10.31 | 9.42 | 12 | 158458 | 1123 | 79584795 |
Unwanted awareness during anaesthesia | 10.31 | 9.42 | 7 | 158463 | 319 | 79585599 |
Local reaction | 10.29 | 9.42 | 9 | 158461 | 598 | 79585320 |
Lower limb fracture | 10.28 | 9.42 | 19 | 158451 | 23196 | 79562722 |
Myokymia | 10.26 | 9.42 | 5 | 158465 | 120 | 79585798 |
Cold sweat | 10.25 | 9.42 | 68 | 158402 | 18631 | 79567287 |
Premature baby | 10.25 | 9.42 | 23 | 158447 | 3757 | 79582161 |
Administration site pruritus | 10.24 | 9.42 | 4 | 158466 | 55 | 79585863 |
Non-infectious endophthalmitis | 10.21 | 9.42 | 7 | 158463 | 324 | 79585594 |
Troponin T increased | 10.20 | 9.42 | 22 | 158448 | 3500 | 79582418 |
Vocal cord dysfunction | 10.19 | 9.42 | 9 | 158461 | 606 | 79585312 |
Acute respiratory distress syndrome | 10.16 | 9.42 | 133 | 158337 | 43934 | 79541984 |
Full blood count decreased | 10.15 | 9.42 | 24 | 158446 | 26795 | 79559123 |
Type IV hypersensitivity reaction | 10.15 | 9.42 | 24 | 158446 | 4057 | 79581861 |
Retinal ischaemia | 10.11 | 9.42 | 10 | 158460 | 778 | 79585140 |
Metastases to lymph nodes | 10.09 | 9.42 | 4 | 158466 | 10393 | 79575525 |
Device issue | 10.07 | 9.42 | 90 | 158380 | 27018 | 79558900 |
Drug interaction | 10.05 | 9.42 | 700 | 157770 | 414483 | 79171435 |
Benign vulval neoplasm | 10.04 | 9.42 | 4 | 158466 | 58 | 79585860 |
Injection site oedema | 10.04 | 9.42 | 13 | 158457 | 1358 | 79584560 |
pH body fluid abnormal | 10.04 | 9.42 | 5 | 158465 | 126 | 79585792 |
Anal skin tags | 10.01 | 9.42 | 8 | 158462 | 469 | 79585449 |
Larynx irritation | 10.00 | 9.42 | 5 | 158465 | 127 | 79585791 |
Anal ulcer | 9.99 | 9.42 | 13 | 158457 | 1365 | 79584553 |
Complex regional pain syndrome | 9.97 | 9.42 | 16 | 158454 | 2032 | 79583886 |
Obstructive airways disorder | 9.97 | 9.42 | 101 | 158369 | 31358 | 79554560 |
Facet joint syndrome | 9.95 | 9.42 | 5 | 158465 | 11297 | 79574621 |
Concomitant disease aggravated | 9.94 | 9.42 | 7 | 158463 | 13160 | 79572758 |
Electrocardiogram U wave present | 9.89 | 9.42 | 5 | 158465 | 130 | 79585788 |
Influenza | 9.87 | 9.42 | 332 | 158138 | 129274 | 79456644 |
Product confusion | 9.87 | 9.42 | 3 | 158467 | 18 | 79585900 |
Blood glucose increased | 9.79 | 9.42 | 165 | 158305 | 114810 | 79471108 |
Sleep disorder | 9.76 | 9.42 | 116 | 158354 | 85561 | 79500357 |
Nephropathy toxic | 9.69 | 9.42 | 16 | 158454 | 20403 | 79565515 |
Adjustment disorder with depressed mood | 9.67 | 9.42 | 3 | 158467 | 9083 | 79576835 |
Corneal opacity | 9.63 | 9.42 | 11 | 158459 | 1009 | 79584909 |
Cerebral haemorrhage | 9.62 | 9.42 | 71 | 158399 | 57602 | 79528316 |
Vitreous floaters | 9.59 | 9.42 | 34 | 158436 | 7222 | 79578696 |
Oesophageal obstruction | 9.58 | 9.42 | 11 | 158459 | 1015 | 79584903 |
Serum amyloid A protein increased | 9.58 | 9.42 | 7 | 158463 | 359 | 79585559 |
Incorrect product formulation administered | 9.56 | 9.42 | 5 | 158465 | 140 | 79585778 |
Neuralgia | 9.56 | 9.42 | 105 | 158365 | 33279 | 79552639 |
Arrhythmia | 9.53 | 9.42 | 173 | 158297 | 61099 | 79524819 |
Drainage | 9.52 | 9.42 | 5 | 158465 | 141 | 79585777 |
Intraocular pressure fluctuation | 9.52 | 9.42 | 4 | 158466 | 67 | 79585851 |
Sudden death | 9.47 | 9.42 | 19 | 158451 | 22492 | 79563426 |
Toxic epidermal necrolysis | 9.43 | 9.42 | 51 | 158419 | 44530 | 79541388 |
Multiple sclerosis relapse | 9.43 | 9.42 | 54 | 158416 | 46479 | 79539439 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Methaemoglobinaemia | 32.77 | 29.15 | 10 | 151 | 71 | 89560 |
Cardiac arrest neonatal | 31.31 | 29.15 | 10 | 151 | 84 | 89547 |
Source | Code | Description |
---|---|---|
ATC | A01AD01 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Other agents for local oral treatment |
ATC | B02BC09 | BLOOD AND BLOOD FORMING ORGANS ANTIHEMORRHAGICS VITAMIN K AND OTHER HEMOSTATICS Local hemostatics |
ATC | C01CA24 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES Adrenergic and dopaminergic agents |
ATC | R01AA14 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Sympathomimetics, plain |
ATC | R03AA01 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Alpha- and beta-adrenoreceptor agonists |
ATC | R03AK01 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics |
ATC | S01EA01 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Sympathomimetics in glaucoma therapy |
ATC | S01EA51 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Sympathomimetics in glaucoma therapy |
FDA CS | M0003647 | Catecholamines |
FDA MoA | N0000000209 | Adrenergic alpha-Agonists |
FDA MoA | N0000000245 | Adrenergic beta-Agonists |
FDA EPC | N0000175552 | alpha-Adrenergic Agonist |
FDA EPC | N0000175555 | beta-Adrenergic Agonist |
FDA EPC | N0000175570 | Catecholamine |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D000322 | Adrenergic Agonists |
MeSH PA | D000316 | Adrenergic alpha-Agonists |
MeSH PA | D000318 | Adrenergic beta-Agonists |
MeSH PA | D018927 | Anti-Asthmatic Agents |
MeSH PA | D001993 | Bronchodilator Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D009184 | Mydriatics |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D019141 | Respiratory System Agents |
MeSH PA | D013566 | Sympathomimetics |
MeSH PA | D014662 | Vasoconstrictor Agents |
CHEBI has role | CHEBI:24621 | hormones |
CHEBI has role | CHEBI:35522 | beta-adrenergic agonists |
CHEBI has role | CHEBI:35523 | bronchodilator |
CHEBI has role | CHEBI:35524 | sympathomimetic |
CHEBI has role | CHEBI:35569 | alpha-adrenergic agonists |
CHEBI has role | CHEBI:35620 | vasodilator agents |
CHEBI has role | CHEBI:37886 | adrenergic agonists |
CHEBI has role | CHEBI:50513 | mydriatics |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Bronchiectasis | indication | 12295008 | DOID:9563 |
Bronchitis | indication | 32398004 | DOID:6132 |
Anaphylaxis | indication | 39579001 | |
Local anesthesia, by infiltration | indication | 44596000 | |
Low blood pressure | indication | 45007003 | |
Wheezing | indication | 56018004 | |
Hypotension associated with septic shock | indication | 76571007 | |
Open-angle glaucoma | indication | 84494001 | DOID:1067 |
Pulmonary emphysema | indication | 87433001 | |
Dyspnea | indication | 267036007 | |
Exacerbation of asthma | indication | 281239006 | |
Asthma management | indication | 406162001 | |
Acute exacerbation of asthma | indication | 708038006 | |
Administration of Local Anesthetic Nerve Block | indication | ||
Allergic Reactions | indication | ||
Ventricular fibrillation | off-label use | 71908006 | |
Asthma | off-label use | 195967001 | DOID:2841 |
Local anesthesia | off-label use | 386761002 | |
Cardiac arrest | off-label use | 410429000 | DOID:0060319 |
Keratitis | contraindication | 5888003 | DOID:4677 |
Bacterial septicemia | contraindication | 10001005 | DOID:0040085 |
Sinus tachycardia | contraindication | 11092001 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Aphakia | contraindication | 24010005 | |
Complete atrioventricular block | contraindication | 27885002 | |
Shock | contraindication | 27942005 | |
Hypovolemia | contraindication | 28560003 | |
Hypercapnia | contraindication | 29596007 | |
Parkinsonism | contraindication | 32798002 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Retinal detachment | contraindication | 42059000 | DOID:5327 |
Hypokalemia | contraindication | 43339004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Stokes-Adams syndrome | contraindication | 46935006 | |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Atrial fibrillation | contraindication | 49436004 | DOID:0060224 |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Sinus bradycardia | contraindication | 49710005 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Iritis | contraindication | 65074000 | DOID:1406 |
Cerebral arteriosclerosis | contraindication | 65312002 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Wolff-Parkinson-White pattern | contraindication | 74390002 | DOID:384 |
Decreased respiratory function | contraindication | 80954004 | |
Cardiogenic shock | contraindication | 89138009 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Open wound | contraindication | 125643001 | |
Seizure disorder | contraindication | 128613002 | |
Bleeding | contraindication | 131148009 | |
Angina pectoris | contraindication | 194828000 | |
Primary dilated cardiomyopathy | contraindication | 195021004 | |
Partial atrioventricular block | contraindication | 195039008 | |
Heart block | contraindication | 233916004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Sepsis syndrome | contraindication | 238150007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Psychoneurotic personality disorder | contraindication | 268634009 | |
Deficiency of cholinesterase | contraindication | 360607009 | |
Hypoxia | contraindication | 389086002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Peripheral vascular disease | contraindication | 400047006 | |
Anterior uveitis | contraindication | 410692006 | DOID:1407 |
Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
Disorder of coronary artery | contraindication | 414024009 | |
Denuded skin | contraindication | 418242004 | |
Thrombosis | contraindication | 439127006 | |
Pupillary Block Glaucoma | contraindication | ||
Occlusive Vascular Disease | contraindication | ||
Lidocaine Toxicity | contraindication | ||
Regional Anesthesia for Labor Pain | contraindication | ||
Reduced Hepatic Blood Flow | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.97 | acidic |
pKa2 | 12.82 | acidic |
pKa3 | 13.64 | acidic |
pKa4 | 8.71 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9833573 | Nov. 23, 2024 | METHOD TO TREAT SEVERE ALLERGIC EMERGENCIES IN PATIENTS WEIGHING 7.5 TO 15 KG (16.5 TO 33 LBS) |
EQ 0.15MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9149579 | July 19, 2025 | METHOD OF TREATING ALLERGIC REACTION VIA INJECTION |
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9149579 | July 19, 2025 | METHOD OF TREATING ALLERGIC REACTION VIA INJECTION |
EQ 0.3MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9149579 | July 19, 2025 | METHOD OF TREATING ALLERGIC REACTION VIA INJECTION |
EQ 0.15MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9724471 | May 23, 2027 | METHOD FOR CONFIRMING DOSE DELIVERY |
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9724471 | May 23, 2027 | METHOD FOR CONFIRMING DOSE DELIVERY |
EQ 0.3MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 9724471 | May 23, 2027 | METHOD FOR CONFIRMING DOSE DELIVERY |
1MG/ML (1MG/ML) | EPINEPHRINE | BPI LABS | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 10004700 | Aug. 14, 2034 | EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE 1), INCLUDING ANAPHYLAXIS; A METHOD OF TREATING ALLERGIC REACTION, ANAPHYLAXIS, ANAPHYLACTIC SHOCK, OR COMBINATION THEREOF BY AN INJECTION OF AT LEAST ONE DOSAGE OF THE INJECTABLE LIQUID PHARMACEUTICAL |
1MG/ML (1MG/ML) | EPINEPHRINE | BPI LABS | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 10039728 | Aug. 14, 2034 | INCREASING MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK |
1MG/ML (1MG/ML) | EPINEPHRINE | BPI LABS | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 9283197 | Aug. 15, 2034 | EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS |
1MG/ML (1MG/ML) | EPINEPHRINE | BPI LABS | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 9283197 | Aug. 15, 2034 | INCREASING MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK |
1MG/ML (1MG/ML) | EPINEPHRINE | BPI LABS | N205029 | July 29, 2014 | RX | SOLUTION | INTRAVENOUS, INTRAOCULAR, INTRAMUSCULAR, SUBCUTANEOUS | 9283197 | Aug. 15, 2034 | INDUCTION AND MAINTENANCE OF MYDRIASIS DURING INTRAOCULAR SURGERY |
EQ 1MG BASE/ML (EQ 1MG BASE/ML) | ADRENALIN | PAR STERILE PRODUCTS | N204200 | Dec. 7, 2012 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS | 9295657 | March 13, 2035 | EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS |
EQ 30MG BASE/30ML (EQ 1MG BASE/ML) | ADRENALIN | PAR STERILE PRODUCTS | N204640 | Dec. 18, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS | 9295657 | March 13, 2035 | EMERGENCY TREATMENT OF ALLERGIC REACTIONS (TYPE I), INCLUDING ANAPHYLAXIS |
0.15MG/0.3ML (0.15MG/0.3ML) | SYMJEPI | ADAMIS PHARMS CORP | N207534 | Sept. 27, 2018 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 11141540 | Oct. 20, 2036 | A METHOD FOR ADMINISTERING A THERAPEUTIC DOSE OF EPINEPHRINE |
0.3MG/0.3ML (0.3MG/0.3ML) | SYMJEPI | ADAMIS PHARMS CORP | N207534 | June 15, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 11141540 | Oct. 20, 2036 | A METHOD FOR ADMINISTERING A THERAPEUTIC DOSE OF EPINEPHRINE |
EQ 0.15MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 10688244 | Dec. 21, 2037 | METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR |
EQ 0.15MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Aug. 10, 2012 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 10842938 | Dec. 21, 2037 | METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR |
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 10688244 | Dec. 21, 2037 | METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR |
EQ 0.1MG/DELIVERY | AUVI-Q | KALEO INC | N201739 | Nov. 17, 2017 | RX | SOLUTION | INTRAMUSCULAR, SUBCUTANEOUS | 10842938 | Dec. 21, 2037 | METHOD OF TREATING AN ALLERGIC REACTION USING AN AUTO-INJECTOR |
10MG/250ML (40MCG/ML) | EPINEPHRINE IN 0.9% SODIUM CHLORIDE | PAR STERILE PRODUCTS | N215875 | April 21, 2023 | RX | SOLUTION | INTRAVENOUS | 11083698 | March 21, 2039 | TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK |
2MG/250ML (8MCG/ML) | EPINEPHRINE IN 0.9% SODIUM CHLORIDE | PAR STERILE PRODUCTS | N215875 | April 21, 2023 | RX | SOLUTION | INTRAVENOUS | 11083698 | March 21, 2039 | TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK |
4MG/250ML (16MCG/ML) | EPINEPHRINE IN 0.9% SODIUM CHLORIDE | PAR STERILE PRODUCTS | N215875 | April 21, 2023 | RX | SOLUTION | INTRAVENOUS | 11083698 | March 21, 2039 | TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK |
5MG/250ML (20MCG/ML) | EPINEPHRINE IN 0.9% SODIUM CHLORIDE | PAR STERILE PRODUCTS | N215875 | April 21, 2023 | RX | SOLUTION | INTRAVENOUS | 11083698 | March 21, 2039 | TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK |
8MG/250ML (32MCG/ML) | EPINEPHRINE IN 0.9% SODIUM CHLORIDE | PAR STERILE PRODUCTS | N215875 | April 21, 2023 | RX | SOLUTION | INTRAVENOUS | 11083698 | March 21, 2039 | TO INCREASE MEAN ARTERIAL BLOOD PRESSURE IN ADULT PATIENTS WITH HYPOTENSION ASSOCIATED WITH SEPTIC SHOCK |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Alpha-1D adrenergic receptor | GPCR | AGONIST | Ki | 6.66 | CHEMBL | CHEMBL | |||
Alpha-1B adrenergic receptor | GPCR | AGONIST | Ki | 6.50 | IUPHAR | CHEMBL | |||
Alpha-2A adrenergic receptor | GPCR | AGONIST | Ki | 6.56 | DRUG MATRIX | CHEMBL | |||
Beta-2 adrenergic receptor | GPCR | AGONIST | Kd | 6.20 | CHEMBL | CHEMBL | |||
Alpha-1A adrenergic receptor | GPCR | AGONIST | Ki | 5.70 | CHEMBL | CHEMBL | |||
Alpha-2B adrenergic receptor | GPCR | AGONIST | Ki | 6.40 | DRUG MATRIX | CHEMBL | |||
Alpha-2C adrenergic receptor | GPCR | AGONIST | Ki | 6.45 | DRUG MATRIX | CHEMBL | |||
Beta-1 adrenergic receptor | GPCR | Ki | 5.40 | PDSP | |||||
D(1A) dopamine receptor | GPCR | Kd | 4.26 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 6.04 | CHEMBL | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.43 | PDSP | |||||
Alpha-1D adrenergic receptor | GPCR | AGONIST | Ki | 6.30 | IUPHAR | ||||
Mu-type opioid receptor | GPCR | Ki | 5.40 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 5.96 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Ki | 6.18 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Ki | 6.14 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 5.52 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | Ki | 7.89 | CHEMBL | |||||
Adrenergic receptor beta | GPCR | IC50 | 4.54 | CHEMBL | |||||
M18 aspartyl aminopeptidase | Enzyme | IC50 | 5.52 | CHEMBL | |||||
Arachidonate 15-lipoxygenase | Enzyme | IC50 | 5.48 | DRUG MATRIX | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 6.01 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 6.20 | CHEMBL |
ID | Source |
---|---|
4018034 | VUID |
N0000146377 | NUI |
D00996 | KEGG_DRUG |
51-42-3 | SECONDARY_CAS_RN |
4018032 | VANDF |
4018033 | VANDF |
4018034 | VANDF |
C0014563 | UMLSCUI |
CHEBI:28918 | CHEBI |
CHEMBL679 | ChEMBL_ID |
DB00668 | DRUGBANK_ID |
CHEMBL1256958 | ChEMBL_ID |
D004837 | MESH_DESCRIPTOR_UI |
5816 | PUBCHEM_CID |
2142 | INN_ID |
55-31-2 | SECONDARY_CAS_RN |
YKH834O4BH | UNII |
203180 | RXNORM |
3451 | MMSL |
3500 | MMSL |
4663 | MMSL |
4664 | MMSL |
4665 | MMSL |
4667 | MMSL |
72412 | MMSL |
d00699 | MMSL |
001774 | NDDF |
001776 | NDDF |
006223 | NDDF |
126134000 | SNOMEDCT_US |
387362001 | SNOMEDCT_US |
50685004 | SNOMEDCT_US |
65502005 | SNOMEDCT_US |
ALE | PDB_CHEM_ID |
CHEMBL3183376 | ChEMBL_ID |
479 | IUPHAR_LIGAND_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5985 | INJECTION | 0.15 mg | INTRAMUSCULAR | ANDA | 24 sections |
Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5986 | INJECTION | 0.30 mg | INTRAMUSCULAR | ANDA | 24 sections |
epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1694 | INJECTION | 0.30 mg | SUBCUTANEOUS | NDA AUTHORIZED GENERIC | 25 sections |
epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1694 | INJECTION | 0.30 mg | SUBCUTANEOUS | NDA AUTHORIZED GENERIC | 25 sections |
epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1695 | INJECTION | 0.15 mg | SUBCUTANEOUS | NDA AUTHORIZED GENERIC | 25 sections |
epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1695 | INJECTION | 0.15 mg | SUBCUTANEOUS | NDA AUTHORIZED GENERIC | 25 sections |
LIDOCAINE HCl and EPINEPHRINE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0264-9378 | INJECTION | 0.01 mg | EPIDURAL | ANDA | 12 sections |
Lidocaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0262 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 23 sections |
Lidocaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0262 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 23 sections |
Marcaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0557 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 19 sections |
Zorcaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0830 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | NDA | 29 sections |
Zorcaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0830 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | NDA | 29 sections |
Lidocaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0898 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 23 sections |
Lidocaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-0898 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 23 sections |
Lignospan Standard | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-1095 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 23 sections |
Lignospan Standard | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-1095 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 23 sections |
Lignospan Forte | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-1096 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 23 sections |
Lignospan Forte | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-1096 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 23 sections |
Octocaine 50 | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9010 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 24 sections |
Vivacaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9011 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 19 sections |
Vivacaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9011 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 19 sections |
Vivacaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9011 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 19 sections |
Prilocaine Hydrochloride with Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9013 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 24 sections |
Octocaine 100 | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9023 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 24 sections |
Septocaine and Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9048 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | NDA | 29 sections |
Septocaine and Epinephrine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0362-9049 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | NDA | 29 sections |
LIDOCAINE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-6500 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 24 sections |
LIDOCAINE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-6500 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 24 sections |
LIDOCAINE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-6500 | INJECTION, SOLUTION | 0.02 mg | SUBCUTANEOUS | ANDA | 24 sections |
Lidocaine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0404-6512 | INJECTION, SOLUTION | 0.01 mg | SUBCUTANEOUS | ANDA | 24 sections |