Stem definition | Drug id | CAS RN |
---|---|---|
catechol-O-methyltransferase (COMT) inhibitors | 1018 | 130929-57-6 |
Dose | Unit | Route |
---|---|---|
1 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.02 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.20 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 87.35 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 42 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.27 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 12 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 19, 1999 | FDA | ORION PHARMA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Dyskinesia | 429.87 | 23.50 | 139 | 4217 | 27722 | 50573046 |
Hallucination | 252.78 | 23.50 | 108 | 4248 | 46549 | 50554219 |
On and off phenomenon | 146.58 | 23.50 | 32 | 4324 | 1380 | 50599388 |
Hallucination, visual | 143.94 | 23.50 | 54 | 4302 | 16528 | 50584240 |
Dystonia | 111.39 | 23.50 | 41 | 4315 | 11885 | 50588883 |
Psychotic disorder | 106.46 | 23.50 | 47 | 4309 | 21765 | 50579003 |
Therapeutic response shortened | 98.07 | 23.50 | 33 | 4323 | 7356 | 50593412 |
Compulsive shopping | 95.70 | 23.50 | 20 | 4336 | 698 | 50600070 |
Sudden onset of sleep | 95.62 | 23.50 | 19 | 4337 | 513 | 50600255 |
Impulse-control disorder | 91.25 | 23.50 | 19 | 4337 | 651 | 50600117 |
Mutism | 87.83 | 23.50 | 21 | 4335 | 1360 | 50599408 |
Delusion | 86.53 | 23.50 | 33 | 4323 | 10536 | 50590232 |
Dopamine dysregulation syndrome | 74.85 | 23.50 | 13 | 4343 | 163 | 50600605 |
Acute psychosis | 68.62 | 23.50 | 19 | 4337 | 2201 | 50598567 |
Muscle rigidity | 67.43 | 23.50 | 27 | 4329 | 9802 | 50590966 |
Akinesia | 61.28 | 23.50 | 16 | 4340 | 1483 | 50599285 |
Stereotypy | 58.85 | 23.50 | 12 | 4344 | 370 | 50600398 |
Freezing phenomenon | 57.18 | 23.50 | 14 | 4342 | 1001 | 50599767 |
Camptocormia | 55.60 | 23.50 | 11 | 4345 | 290 | 50600478 |
Tremor | 52.98 | 23.50 | 57 | 4299 | 114846 | 50485922 |
Dysphagia | 49.66 | 23.50 | 46 | 4310 | 77472 | 50523296 |
Orthostatic hypotension | 49.22 | 23.50 | 31 | 4325 | 29450 | 50571318 |
Fall | 47.62 | 23.50 | 95 | 4261 | 334837 | 50265931 |
Gambling | 45.87 | 23.50 | 9 | 4347 | 227 | 50600541 |
Parkinsonian gait | 45.77 | 23.50 | 10 | 4346 | 432 | 50600336 |
Gait disturbance | 45.34 | 23.50 | 60 | 4296 | 149945 | 50450823 |
Confusional state | 43.80 | 23.50 | 66 | 4290 | 185862 | 50414906 |
Impulsive behaviour | 42.87 | 23.50 | 12 | 4344 | 1446 | 50599322 |
Agitation | 42.82 | 23.50 | 36 | 4320 | 53348 | 50547420 |
Aggression | 42.41 | 23.50 | 25 | 4331 | 21091 | 50579677 |
Hyperkinesia | 38.39 | 23.50 | 11 | 4345 | 1441 | 50599327 |
Therapeutic product effect variable | 36.79 | 23.50 | 10 | 4346 | 1080 | 50599688 |
Pleurothotonus | 35.04 | 23.50 | 10 | 4346 | 1291 | 50599477 |
Wrong technique in product usage process | 33.72 | 23.50 | 32 | 4324 | 55478 | 50545290 |
Neuroleptic malignant syndrome | 32.88 | 23.50 | 17 | 4339 | 11113 | 50589655 |
Gambling disorder | 31.36 | 23.50 | 9 | 4347 | 1185 | 50599583 |
Stoma site discharge | 30.78 | 23.50 | 9 | 4347 | 1266 | 50599502 |
Eating disorder | 30.30 | 23.50 | 18 | 4338 | 15391 | 50585377 |
Stoma site erythema | 29.26 | 23.50 | 8 | 4348 | 883 | 50599885 |
Delirium | 29.06 | 23.50 | 25 | 4331 | 38167 | 50562601 |
Bradykinesia | 27.62 | 23.50 | 11 | 4345 | 3932 | 50596836 |
Rash | 27.21 | 23.50 | 3 | 4353 | 437468 | 50163300 |
Parkinson's disease | 26.94 | 23.50 | 8 | 4348 | 1187 | 50599581 |
Femoral neck fracture | 26.71 | 23.50 | 13 | 4343 | 7477 | 50593291 |
Posture abnormal | 26.41 | 23.50 | 9 | 4347 | 2080 | 50598688 |
Abnormal behaviour | 26.28 | 23.50 | 18 | 4338 | 19640 | 50581128 |
Balance disorder | 25.67 | 23.50 | 31 | 4325 | 70559 | 50530209 |
Parkinsonism hyperpyrexia syndrome | 25.30 | 23.50 | 5 | 4351 | 131 | 50600637 |
Ileus | 24.83 | 23.50 | 15 | 4341 | 13214 | 50587554 |
Parkinsonism | 24.67 | 23.50 | 13 | 4343 | 8834 | 50591934 |
Somnolence | 24.40 | 23.50 | 46 | 4310 | 154939 | 50445829 |
Teeth brittle | 23.76 | 23.50 | 6 | 4350 | 487 | 50600281 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Dyskinesia | 270.13 | 22.63 | 116 | 6301 | 19945 | 29548165 |
Hallucination | 269.25 | 22.63 | 149 | 6268 | 44563 | 29523547 |
Hypersexuality | 227.99 | 22.63 | 54 | 6363 | 1302 | 29566808 |
Hallucination, visual | 209.21 | 22.63 | 89 | 6328 | 14926 | 29553184 |
Gambling disorder | 204.82 | 22.63 | 51 | 6366 | 1524 | 29566586 |
On and off phenomenon | 189.79 | 22.63 | 50 | 6367 | 1878 | 29566232 |
Muscle rigidity | 162.28 | 22.63 | 65 | 6352 | 9346 | 29558764 |
Delusion | 116.02 | 22.63 | 54 | 6363 | 11162 | 29556948 |
Freezing phenomenon | 115.93 | 22.63 | 31 | 6386 | 1232 | 29566878 |
Dysphagia | 98.31 | 22.63 | 87 | 6330 | 54839 | 29513271 |
Parkinson's disease | 95.27 | 22.63 | 27 | 6390 | 1334 | 29566776 |
Fall | 92.27 | 22.63 | 149 | 6268 | 177029 | 29391081 |
Dopamine dysregulation syndrome | 76.13 | 22.63 | 17 | 6400 | 312 | 29567798 |
Neuroleptic malignant syndrome | 68.44 | 22.63 | 43 | 6374 | 16105 | 29552005 |
Akinesia | 64.95 | 22.63 | 22 | 6395 | 1968 | 29566142 |
Bradykinesia | 63.53 | 22.63 | 25 | 6392 | 3422 | 29564688 |
Tremor | 58.87 | 22.63 | 76 | 6341 | 73462 | 29494648 |
Cognitive disorder | 58.22 | 22.63 | 45 | 6372 | 23454 | 29544656 |
Impulse-control disorder | 58.17 | 22.63 | 18 | 6399 | 1207 | 29566903 |
Dementia | 54.36 | 22.63 | 33 | 6384 | 11625 | 29556485 |
Confusional state | 51.27 | 22.63 | 96 | 6321 | 127781 | 29440329 |
Gait disturbance | 48.35 | 22.63 | 69 | 6348 | 73280 | 29494830 |
Aggression | 47.61 | 22.63 | 48 | 6369 | 35493 | 29532617 |
Paranoia | 43.60 | 22.63 | 27 | 6390 | 9850 | 29558260 |
Agitation | 42.55 | 22.63 | 54 | 6363 | 51250 | 29516860 |
Stoma site discharge | 41.55 | 22.63 | 13 | 6404 | 904 | 29567206 |
Device dislocation | 41.28 | 22.63 | 20 | 6397 | 4507 | 29563603 |
Reduced facial expression | 40.50 | 22.63 | 12 | 6405 | 694 | 29567416 |
Therapeutic response shortened | 40.21 | 22.63 | 20 | 6397 | 4771 | 29563339 |
Compulsive shopping | 37.71 | 22.63 | 10 | 6407 | 384 | 29567726 |
Persecutory delusion | 37.60 | 22.63 | 15 | 6402 | 2126 | 29565984 |
Pneumonia aspiration | 37.54 | 22.63 | 43 | 6374 | 36694 | 29531416 |
Stereotypy | 36.92 | 22.63 | 11 | 6406 | 648 | 29567462 |
Delirium | 36.74 | 22.63 | 44 | 6373 | 39353 | 29528757 |
Therapeutic product effect variable | 35.95 | 22.63 | 14 | 6403 | 1863 | 29566247 |
Psychotic disorder | 35.85 | 22.63 | 32 | 6385 | 20322 | 29547788 |
Posture abnormal | 35.45 | 22.63 | 14 | 6403 | 1933 | 29566177 |
Therapeutic product effect decreased | 34.44 | 22.63 | 37 | 6380 | 29414 | 29538696 |
Jealous delusion | 33.40 | 22.63 | 8 | 6409 | 202 | 29567908 |
Sudden onset of sleep | 33.32 | 22.63 | 9 | 6408 | 371 | 29567739 |
Abnormal behaviour | 32.36 | 22.63 | 32 | 6385 | 23095 | 29545015 |
Obsessive-compulsive disorder | 32.30 | 22.63 | 17 | 6400 | 4559 | 29563551 |
Hyperkinesia | 30.88 | 22.63 | 12 | 6405 | 1587 | 29566523 |
Stoma site pain | 30.55 | 22.63 | 9 | 6408 | 510 | 29567600 |
Device issue | 28.71 | 22.63 | 19 | 6398 | 7761 | 29560349 |
Somnolence | 28.61 | 22.63 | 63 | 6354 | 93892 | 29474218 |
Illusion | 27.87 | 22.63 | 9 | 6408 | 693 | 29567417 |
Somatic delusion | 27.58 | 22.63 | 6 | 6411 | 97 | 29568013 |
Tricuspid valve sclerosis | 27.46 | 22.63 | 5 | 6412 | 30 | 29568080 |
Mitral valve sclerosis | 26.87 | 22.63 | 6 | 6411 | 110 | 29568000 |
Balance disorder | 26.75 | 22.63 | 36 | 6381 | 36134 | 29531976 |
Mobility decreased | 26.03 | 22.63 | 30 | 6387 | 25750 | 29542360 |
Abnormal dreams | 25.78 | 22.63 | 17 | 6400 | 6903 | 29561207 |
Progressive supranuclear palsy | 25.39 | 22.63 | 5 | 6412 | 48 | 29568062 |
Gastric fistula | 23.59 | 22.63 | 5 | 6412 | 71 | 29568039 |
Parkinsonism hyperpyrexia syndrome | 22.86 | 22.63 | 5 | 6412 | 83 | 29568027 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Dyskinesia | 554.59 | 23.06 | 204 | 8207 | 39184 | 64451137 |
Hallucination | 375.77 | 23.06 | 185 | 8226 | 72603 | 64417718 |
Hallucination, visual | 314.81 | 23.06 | 123 | 8288 | 27711 | 64462610 |
On and off phenomenon | 258.22 | 23.06 | 61 | 8350 | 2458 | 64487863 |
Hypersexuality | 245.01 | 23.06 | 53 | 8358 | 1426 | 64488895 |
Gambling disorder | 205.32 | 23.06 | 48 | 8363 | 1846 | 64488475 |
Muscle rigidity | 162.07 | 23.06 | 67 | 8344 | 17406 | 64472915 |
Delusion | 146.78 | 23.06 | 63 | 8348 | 17951 | 64472370 |
Impulse-control disorder | 129.56 | 23.06 | 32 | 8379 | 1556 | 64488765 |
Therapeutic response shortened | 125.72 | 23.06 | 48 | 8363 | 10122 | 64480199 |
Dopamine dysregulation syndrome | 124.90 | 23.06 | 25 | 8386 | 454 | 64489867 |
Psychotic disorder | 118.55 | 23.06 | 67 | 8344 | 34511 | 64455810 |
Dystonia | 115.41 | 23.06 | 54 | 8357 | 18811 | 64471510 |
Freezing phenomenon | 110.39 | 23.06 | 28 | 8383 | 1518 | 64488803 |
Compulsive shopping | 107.36 | 23.06 | 24 | 8387 | 753 | 64489568 |
Akinesia | 104.20 | 23.06 | 31 | 8380 | 3048 | 64487273 |
Dysphagia | 95.97 | 23.06 | 92 | 8319 | 106720 | 64383601 |
Parkinson's disease | 94.88 | 23.06 | 25 | 8386 | 1576 | 64488745 |
Stereotypy | 94.74 | 23.06 | 22 | 8389 | 820 | 64489501 |
Fall | 94.50 | 23.06 | 183 | 8228 | 416643 | 64073678 |
Neuroleptic malignant syndrome | 92.66 | 23.06 | 51 | 8360 | 24945 | 64465376 |
Sudden onset of sleep | 85.36 | 23.06 | 19 | 8392 | 584 | 64489737 |
Confusional state | 84.22 | 23.06 | 134 | 8277 | 261010 | 64229311 |
Aggression | 79.50 | 23.06 | 58 | 8353 | 46174 | 64444147 |
Agitation | 79.13 | 23.06 | 76 | 8335 | 88291 | 64402030 |
Bradykinesia | 77.63 | 23.06 | 30 | 8381 | 6530 | 64483791 |
Tremor | 75.93 | 23.06 | 95 | 8316 | 148135 | 64342186 |
Mutism | 75.49 | 23.06 | 22 | 8389 | 2012 | 64488309 |
Therapeutic product effect variable | 70.95 | 23.06 | 20 | 8391 | 1624 | 64488697 |
Gait disturbance | 70.70 | 23.06 | 99 | 8312 | 172056 | 64318265 |
Acute psychosis | 62.25 | 23.06 | 22 | 8389 | 3730 | 64486591 |
Delirium | 60.96 | 23.06 | 59 | 8352 | 69135 | 64421186 |
Hyperkinesia | 58.25 | 23.06 | 19 | 8392 | 2527 | 64487794 |
Cognitive disorder | 54.30 | 23.06 | 50 | 8361 | 55037 | 64435284 |
Orthostatic hypotension | 53.16 | 23.06 | 46 | 8365 | 46692 | 64443629 |
Abnormal behaviour | 52.89 | 23.06 | 40 | 8371 | 33582 | 64456739 |
Camptocormia | 51.12 | 23.06 | 12 | 8399 | 469 | 64489852 |
Persecutory delusion | 49.14 | 23.06 | 19 | 8392 | 4139 | 64486182 |
Parkinsonian gait | 49.08 | 23.06 | 13 | 8398 | 836 | 64489485 |
Parkinsonism hyperpyrexia syndrome | 48.13 | 23.06 | 10 | 8401 | 220 | 64490101 |
Dementia | 47.33 | 23.06 | 31 | 8380 | 20735 | 64469586 |
Gambling | 45.85 | 23.06 | 10 | 8401 | 279 | 64490042 |
Posture abnormal | 45.42 | 23.06 | 17 | 8394 | 3389 | 64486932 |
Stoma site discharge | 44.42 | 23.06 | 14 | 8397 | 1668 | 64488653 |
Progressive supranuclear palsy | 42.54 | 23.06 | 8 | 8403 | 103 | 64490218 |
Paranoia | 41.19 | 23.06 | 26 | 8385 | 16326 | 64473995 |
Blood creatine phosphokinase increased | 40.77 | 23.06 | 44 | 8367 | 58514 | 64431807 |
Reduced facial expression | 37.39 | 23.06 | 13 | 8398 | 2100 | 64488221 |
Illusion | 37.06 | 23.06 | 12 | 8399 | 1558 | 64488763 |
Torticollis | 37.01 | 23.06 | 13 | 8398 | 2164 | 64488157 |
Pneumonia aspiration | 36.89 | 23.06 | 42 | 8369 | 59229 | 64431092 |
Jealous delusion | 36.83 | 23.06 | 8 | 8403 | 219 | 64490102 |
Arthralgia | 36.06 | 23.06 | 7 | 8404 | 442253 | 64048068 |
Device issue | 35.74 | 23.06 | 27 | 8384 | 22621 | 64467700 |
Impulsive behaviour | 34.45 | 23.06 | 13 | 8398 | 2650 | 64487671 |
Resting tremor | 34.17 | 23.06 | 11 | 8400 | 1403 | 64488918 |
Parkinsonism | 34.08 | 23.06 | 22 | 8389 | 14351 | 64475970 |
Gastric fistula | 33.78 | 23.06 | 7 | 8404 | 152 | 64490169 |
Wrong technique in product usage process | 33.77 | 23.06 | 42 | 8369 | 64932 | 64425389 |
Depressed level of consciousness | 30.67 | 23.06 | 45 | 8366 | 81391 | 64408930 |
Somnolence | 30.61 | 23.06 | 76 | 8335 | 203569 | 64286752 |
Obsessive-compulsive disorder | 30.09 | 23.06 | 14 | 8397 | 4804 | 64485517 |
Tricuspid valve sclerosis | 30.00 | 23.06 | 5 | 8406 | 30 | 64490291 |
Nightmare | 28.72 | 23.06 | 23 | 8388 | 20970 | 64469351 |
Restlessness | 27.87 | 23.06 | 30 | 8381 | 39755 | 64450566 |
Femoral neck fracture | 27.45 | 23.06 | 16 | 8395 | 8708 | 64481613 |
Deep brain stimulation | 27.15 | 23.06 | 5 | 8406 | 57 | 64490264 |
Mania | 26.99 | 23.06 | 20 | 8391 | 16266 | 64474055 |
Balance disorder | 26.85 | 23.06 | 43 | 8368 | 83883 | 64406438 |
Anxiety | 25.72 | 23.06 | 71 | 8340 | 202578 | 64287743 |
Pleurothotonus | 25.37 | 23.06 | 10 | 8401 | 2292 | 64488029 |
Obsessive thoughts | 24.93 | 23.06 | 8 | 8403 | 1009 | 64489312 |
Abnormal dreams | 24.92 | 23.06 | 16 | 8395 | 10340 | 64479981 |
Immobile | 24.30 | 23.06 | 13 | 8398 | 6002 | 64484319 |
Stoma site pain | 24.09 | 23.06 | 8 | 8403 | 1125 | 64489196 |
Nocturia | 23.82 | 23.06 | 16 | 8395 | 11149 | 64479172 |
Hyperpyrexia | 23.44 | 23.06 | 12 | 8399 | 5065 | 64485256 |
Stoma site erythema | 23.38 | 23.06 | 8 | 8403 | 1231 | 64489090 |
Hyperthermia | 23.34 | 23.06 | 18 | 8393 | 15532 | 64474789 |
Headache | 23.19 | 23.06 | 21 | 8390 | 529446 | 63960875 |
None
Source | Code | Description |
---|---|---|
ATC | N04BX02 | NERVOUS SYSTEM ANTI-PARKINSON DRUGS DOPAMINERGIC AGENTS Other dopaminergic agents |
CHEBI has role | CHEBI:35470 | central nervous system agents |
CHEBI has role | CHEBI:48406 | catechol O-methyltransferase inhibitors |
CHEBI has role | CHEBI:48407 | antiparkinson agent |
CHEBI has role | CHEBI:66956 | antidyskinetic agent |
MeSH PA | D018726 | Anti-Dyskinesia Agents |
MeSH PA | D000978 | Antiparkinson Agents |
MeSH PA | D065098 | Catechol O-Methyltransferase Inhibitors |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
FDA MoA | N0000175756 | Catechol O-Methyltransferase Inhibitors |
FDA EPC | N0000175757 | Catechol-O-Methyltransferase Inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Parkinson's disease | indication | 49049000 | DOID:14330 |
Suicidal thoughts | contraindication | 6471006 | |
Hallucinations | contraindication | 7011001 | |
Dyskinesia | contraindication | 9748009 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Disorder of lung | contraindication | 19829001 | DOID:850 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Orthostatic hypotension | contraindication | 28651003 | |
Obstruction of bile duct | contraindication | 30144000 | |
Depressive disorder | contraindication | 35489007 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Duodenal ulcer disease | contraindication | 51868009 | DOID:1724 |
Diarrhea | contraindication | 62315008 | |
Psychotic disorder | contraindication | 69322001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Acute disease of cardiovascular system | contraindication | 128487001 | |
Seizure disorder | contraindication | 128613002 | |
Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Retention of urine | contraindication | 267064002 | |
Psychoneurotic personality disorder | contraindication | 268634009 | |
Malignant melanoma | contraindication | 372244006 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Cardiovascular event risk | contraindication | 395112001 | |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.41 | acidic |
pKa2 | 13.34 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Catechol O-methyltransferase | Enzyme | INHIBITOR | Ki | 9.52 | SCIENTIFIC LITERATURE | CHEMBL | |||
G-protein coupled receptor 35 | GPCR | EC50 | 5.25 | CHEMBL | |||||
Alpha-ketoglutarate-dependent dioxygenase FTO | Unclassified | IC50 | 5.52 | CHEMBL | |||||
Catechol O-methyltransferase | Enzyme | IC50 | 7.89 | CHEMBL |
ID | Source |
---|---|
4021181 | VUID |
N0000148629 | NUI |
D00781 | KEGG_DRUG |
4021181 | VANDF |
C0165921 | UMLSCUI |
CHEBI:4798 | CHEBI |
PD9 | PDB_CHEM_ID |
CHEMBL953 | ChEMBL_ID |
DB00494 | DRUGBANK_ID |
C071192 | MESH_SUPPLEMENTAL_RECORD_UI |
5281081 | PUBCHEM_CID |
6647 | IUPHAR_LIGAND_ID |
6812 | INN_ID |
4975G9NM6T | UNII |
227109 | RXNORM |
66346 | MMSL |
8477 | MMSL |
d04460 | MMSL |
007684 | NDDF |
116116003 | SNOMEDCT_US |
387018000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Comtan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0327 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 25 sections |
Stalevo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0407 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 25 sections |
Stalevo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0408 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 25 sections |
Stalevo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0409 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 25 sections |
Stalevo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0527 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 25 sections |
Stalevo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0544 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 25 sections |
Stalevo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0545 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 25 sections |
Carbidopa, Levodopa and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0378-8300 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 24 sections |
Carbidopa, Levodopa and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0378-8301 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 24 sections |
Carbidopa, Levodopa and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0378-8302 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 24 sections |
Carbidopa, Levodopa and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0378-8303 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 24 sections |
Carbidopa, Levodopa and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0378-8304 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 24 sections |
Carbidopa, Levodopa and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0378-8305 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 24 sections |
Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-9080 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 21 sections |
Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1830 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 26 sections |
Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8298 | TABLET | 200 mg | ORAL | ANDA | 19 sections |
Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5578 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 13 sections |
Carbidopa, Levodopa, and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0781-5613 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 26 sections |
Carbidopa, Levodopa, and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0781-5625 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 26 sections |
Carbidopa, Levodopa, and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0781-5637 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 26 sections |
Carbidopa, Levodopa, and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0781-5641 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 26 sections |
Carbidopa, Levodopa, and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0781-5654 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 26 sections |
Carbidopa, Levodopa, and Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0781-5669 | TABLET, FILM COATED | 200 mg | ORAL | NDA authorized generic | 26 sections |
Entacapone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6822 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 20 sections |
CARBIDOPA, LEVODOPA AND ENTACAPONE | Human Prescription Drug Label | 3 | 16571-689 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 26 sections |
CARBIDOPA, LEVODOPA AND ENTACAPONE | Human Prescription Drug Label | 3 | 16571-690 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 26 sections |
CARBIDOPA, LEVODOPA AND ENTACAPONE | Human Prescription Drug Label | 3 | 16571-691 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 26 sections |
CARBIDOPA, LEVODOPA AND ENTACAPONE | Human Prescription Drug Label | 3 | 16571-692 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 26 sections |
CARBIDOPA, LEVODOPA AND ENTACAPONE | Human Prescription Drug Label | 3 | 16571-693 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 26 sections |
CARBIDOPA, LEVODOPA AND ENTACAPONE | Human Prescription Drug Label | 3 | 16571-694 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 26 sections |