enprostil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prostaglandins, anti-ulcer 1016 73121-56-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • RS-84135
  • RS84135
  • enprostil
  • camleed
  • fundyl
  • gardrin
  • gardrine
A synthetic PGE2 analog that has an inhibitory effect on gastric acid secretion, a mucoprotective effect, and a postprandial lowering effect on gastrin. It has been shown to be efficient and safe in the treatment of gastroduodenal ulcers.
  • Molecular weight: 400.47
  • Formula: C23H28O6
  • CLOGP: 1.27
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 93.06
  • ALOGS: -4.43
  • ROTB: 11

Drug dosage:

DoseUnitRoute
70 mcg O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1985 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BB02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Prostaglandins
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D005765 Gastrointestinal Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin E2 receptor EP1 subtype GPCR EC50 7.50 WOMBAT-PK
Prostaglandin E2 receptor EP3 subtype GPCR EC50 7.90 WOMBAT-PK
Prostacyclin receptor GPCR WOMBAT-PK
Prostaglandin E2 receptor EP4 subtype GPCR AGONIST Ki 7.40 IUPHAR
Prostaglandin F2-alpha receptor GPCR AGONIST Ki 7.10 IUPHAR
Prostaglandin E2 receptor EP3 subtype GPCR AGONIST Ki 7.13 IUPHAR
Prostaglandin E2 receptor EP1 subtype GPCR AGONIST Ki 6.70 IUPHAR

External reference:

IDSource
D01891 KEGG_DRUG
C0085191 UMLSCUI
CHEBI:31538 CHEBI
CHEMBL2104194 ChEMBL_ID
D016620 MESH_DESCRIPTOR_UI
DB13824 DRUGBANK_ID
9978336 PUBCHEM_CID
1918 IUPHAR_LIGAND_ID
5382 INN_ID
J4IP5Z9DAU UNII
008238 NDDF

Pharmaceutical products:

None