enprostil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prostaglandins, anti-ulcer | 1016 | 73121-56-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A synthetic PGE2 analog that has an inhibitory effect on gastric acid secretion, a mucoprotective effect, and a postprandial lowering effect on gastrin. It has been shown to be efficient and safe in the treatment of gastroduodenal ulcers.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 70 | mcg | O |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1985 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A02BB02 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Prostaglandins |
| MeSH PA | D000897 | Anti-Ulcer Agents |
| MeSH PA | D005765 | Gastrointestinal Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP1 subtype | GPCR | EC50 | 7.50 | WOMBAT-PK | |||||
| Prostaglandin E2 receptor EP3 subtype | GPCR | EC50 | 7.90 | WOMBAT-PK | |||||
| Prostacyclin receptor | GPCR | WOMBAT-PK | |||||||
| Prostaglandin E2 receptor EP4 subtype | GPCR | AGONIST | Ki | 7.40 | IUPHAR | ||||
| Prostaglandin F2-alpha receptor | GPCR | AGONIST | Ki | 7.10 | IUPHAR | ||||
| Prostaglandin E2 receptor EP3 subtype | GPCR | AGONIST | Ki | 7.13 | IUPHAR | ||||
| Prostaglandin E2 receptor EP1 subtype | GPCR | AGONIST | Ki | 6.70 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| D01891 | KEGG_DRUG |
| C0085191 | UMLSCUI |
| CHEBI:31538 | CHEBI |
| CHEMBL2104194 | ChEMBL_ID |
| D016620 | MESH_DESCRIPTOR_UI |
| DB13824 | DRUGBANK_ID |
| 9978336 | PUBCHEM_CID |
| 1918 | IUPHAR_LIGAND_ID |
| 5382 | INN_ID |
| J4IP5Z9DAU | UNII |
| 008238 | NDDF |
Pharmaceutical products:
None