emetine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1001 | 483-18-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 60 | mg | P |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P01AX02 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES Other agents against amoebiasis and other protozoal diseases |
| ATC | P01AX52 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES Other agents against amoebiasis and other protozoal diseases |
| CHEBI has role | CHEBI:22587 | antiviral agents |
| CHEBI has role | CHEBI:35441 | antiinfective agents |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:35820 | antiprotozoal drugs |
| CHEBI has role | CHEBI:38068 | antimalarials |
| CHEBI has role | CHEBI:48001 | protein synthesis inhibitors |
| CHEBI has role | CHEBI:76924 | plant metabolites |
| CHEBI has role | CHEBI:77035 | expectorants |
| CHEBI has role | CHEBI:88230 | autophagy inhibitors |
| CHEBI has role | CHEBI:149552 | emetics |
| CHEBI has role | CHEBI:149553 | anticoronaviral drug |
| CHEBI has role | CHEBI:171664 | antiamoebic drugs |
| MeSH PA | D000563 | Amebicides |
| MeSH PA | D000871 | Anthelmintics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000969 | Antinematodal Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D000981 | Antiprotozoal Agents |
| MeSH PA | D002400 | Cathartics |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D004639 | Emetics |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D011500 | Protein Synthesis Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.4 | Basic |
| pKa2 | 9.01 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | GPCR | Ki | 7.85 | DRUG MATRIX | |||||
| Alpha-2C adrenergic receptor | GPCR | Ki | 7.59 | DRUG MATRIX | |||||
| Alpha-1D adrenergic receptor | GPCR | Ki | 5.58 | DRUG MATRIX | |||||
| Putative hydrolase RBBP9 | Enzyme | IC50 | 5.11 | CHEMBL | |||||
| Alpha-1B adrenergic receptor | GPCR | Ki | 5.97 | DRUG MATRIX | |||||
| Alpha-1A adrenergic receptor | GPCR | IC50 | 5.19 | CHEMBL | |||||
| NS5 | Unclassified | EC50 | 8.06 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019743 | VUID |
| N0000147834 | NUI |
| 316-42-7 | SECONDARY_CAS_RN |
| 4017461 | VANDF |
| 4019743 | VANDF |
| C0013974 | UMLSCUI |
| CHEBI:4781 | CHEBI |
| 34G | PDB_CHEM_ID |
| CHEMBL50588 | ChEMBL_ID |
| CHEMBL513000 | ChEMBL_ID |
| CHEMBL493439 | ChEMBL_ID |
| D004640 | MESH_DESCRIPTOR_UI |
| DB13393 | DRUGBANK_ID |
| 11087 | IUPHAR_LIGAND_ID |
| X8D5EPO80M | UNII |
| 10219 | PUBCHEM_CID |
| 3820 | RXNORM |
| 002953 | NDDF |
| 004874 | NDDF |
| 12290003 | SNOMEDCT_US |
| 12559001 | SNOMEDCT_US |
| 373466009 | SNOMEDCT_US |
Pharmaceutical products:
None