clotiazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 718 33671-46-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clotiazepam
  • Molecular weight: 318.82
  • Formula: C16H15ClN2OS
  • CLOGP: 3.03
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 32.67
  • ALOGS: -4.77
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Eczema eyelids 47.06 35.62 7 1226 153 63487636
Coma 39.66 35.62 21 1212 64343 63423446
Suicide attempt 37.88 35.62 20 1213 60898 63426891
Inappropriate antidiuretic hormone secretion 36.35 35.62 13 1220 15449 63472340

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Coma 67.67 27.83 36 1681 100613 79642058
Eczema eyelids 45.10 27.83 7 1710 184 79742487
Suicide attempt 40.29 27.83 24 1693 82908 79659763
Inappropriate antidiuretic hormone secretion 34.77 27.83 15 1702 26298 79716373
Miosis 31.15 27.83 12 1705 15777 79726894
Analgesic drug level increased 30.18 27.83 8 1709 3170 79739501
Cross sensitivity reaction 28.95 27.83 8 1709 3704 79738967
Poisoning 28.85 27.83 13 1704 25259 79717412
Somnolence 28.22 27.83 30 1687 238951 79503720

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05BA21 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.55 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01328 KEGG_DRUG
2622 RXNORM
C0009073 UMLSCUI
CHEBI:31425 CHEBI
CHEMBL1697737 ChEMBL_ID
DB01559 DRUGBANK_ID
C084599 MESH_SUPPLEMENTAL_RECORD_UI
2811 PUBCHEM_CID
3496 INN_ID
ZCN055599V UNII
005796 NDDF
698256004 SNOMEDCT_US

Pharmaceutical products:

None