diazepam Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 852 439-14-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • RO-5-2807
  • diazepam
  • valium
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
  • Molecular weight: 284.74
  • Formula: C16H13ClN2O
  • CLOGP: 2.96
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 32.67
  • ALOGS: -4.37
  • ROTB: 1

Drug dosage:

DoseUnitRoute
10 mg O
10 mg P
10 mg R

Approvals:

DateAgencyCompanyOrphan
Nov. 15, 1963 FDA ROCHE

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 15310.16 42.46 4198 14667 67842 4552285
Drug abuse 11601.66 42.46 2800 16065 25147 4594980
Completed suicide 8498.47 42.46 2388 16477 40057 4580070
Overdose 4003.76 42.46 1358 17507 42201 4577926
Respiratory arrest 3650.03 42.46 969 17896 12451 4607676
Coma 3156.34 42.46 916 17949 16603 4603524
Cardiac arrest 3108.67 42.46 1058 17807 32949 4587178
Intentional overdose 2926.18 42.46 908 17957 20858 4599269
Somnolence 2539.60 42.46 973 17892 42687 4577440
Cardio-respiratory arrest 2499.55 42.46 788 18077 19034 4601093
Poisoning 2078.63 42.46 526 18339 5448 4614679
Death 2050.27 42.46 1363 17502 196800 4423327
Suicide attempt 1987.27 42.46 671 18194 20171 4599956
Intentional product misuse 1964.56 42.46 646 18219 17847 4602280
Drug dependence 1869.36 42.46 499 18366 6468 4613659
Sopor 1367.17 42.46 385 18480 6141 4613986
Respiratory depression 1322.53 42.46 356 18509 4754 4615373
Accidental overdose 1259.61 42.46 391 18474 8864 4611263
Drug interaction 1202.51 42.46 652 18213 63856 4556271
Poisoning deliberate 991.08 42.46 240 18625 2022 4618105
Exposure via father 959.40 42.46 185 18680 418 4619709
Depressed level of consciousness 909.27 42.46 347 18518 14807 4605320
Hypotension 903.39 42.46 550 18315 66850 4553277
Intentional self-injury 851.00 42.46 275 18590 7108 4613019
Agitation 841.35 42.46 375 18490 23825 4596302
Small for dates baby 740.99 42.46 186 18679 1841 4618286
Confusional state 709.04 42.46 420 18445 48414 4571713
Sedation 692.18 42.46 238 18627 7479 4612648
Miosis 684.82 42.46 188 18677 2702 4617425
Loss of consciousness 672.01 42.46 364 18501 35318 4584809
Substance abuse 652.49 42.46 162 18703 1526 4618601
Tachycardia 626.40 42.46 332 18533 30813 4589314
Aggression 565.96 42.46 241 18624 13658 4606469
Pneumonia aspiration 552.17 42.46 214 18651 9492 4610635
Bradypnoea 544.46 42.46 122 18743 698 4619429
Drug hypersensitivity 532.21 42.46 399 18466 68001 4552126
Seizure 520.13 42.46 349 18516 49888 4570239
Dysarthria 476.19 42.46 206 18659 12126 4608001
Nystagmus 440.49 42.46 128 18737 2280 4617847
Exposure via ingestion 438.17 42.46 115 18750 1375 4618752
Drug ineffective 435.74 42.46 561 18304 185500 4434627
Pulmonary oedema 431.55 42.46 204 18661 14782 4605345
Foetal exposure during pregnancy 429.09 42.46 234 18631 22935 4597192
Disturbance in attention 429.04 42.46 183 18682 10398 4609729
Fall 427.73 42.46 371 18494 77675 4542452
Electrocardiogram QT prolonged 427.58 42.46 204 18661 15091 4605036
Anxiety 395.18 42.46 290 18575 47721 4572406
Drug withdrawal syndrome 384.88 42.46 179 18686 12493 4607634
Altered state of consciousness 363.77 42.46 150 18715 7821 4612306
Restlessness 351.83 42.46 154 18711 9315 4610812
Accidental death 345.46 42.46 85 18780 767 4619360
Disorientation 341.53 42.46 164 18701 12295 4607832
Congenital nystagmus 340.22 42.46 60 18805 60 4620067
Unresponsive to stimuli 339.21 42.46 153 18712 9940 4610187
Delirium 337.90 42.46 164 18701 12588 4607539
Aspiration 328.85 42.46 113 18752 3532 4616595
Drug abuser 323.04 42.46 104 18761 2643 4617484
Device use error 321.48 42.46 85 18780 1047 4619080
Coma scale abnormal 311.51 42.46 89 18776 1487 4618640
Withdrawal syndrome 307.30 42.46 125 18740 6289 4613838
Prescription drug used without a prescription 306.40 42.46 70 18795 442 4619685
Bradyphrenia 295.49 42.46 89 18776 1802 4618325
Suicidal ideation 295.17 42.46 179 18686 21404 4598723
Asphyxia 293.03 42.46 92 18773 2150 4617977
Pulmonary congestion 289.35 42.46 105 18760 3861 4616266
Depression 285.72 42.46 239 18626 47494 4572633
Vomiting 283.98 42.46 364 18501 119335 4500792
Hypothermia 283.91 42.46 106 18759 4228 4615899
Neuroleptic malignant syndrome 282.17 42.46 114 18751 5633 4614494
Drug withdrawal convulsions 281.26 42.46 69 18796 614 4619513
Abnormal behaviour 280.65 42.46 142 18723 11914 4608213
Psychotic disorder 277.45 42.46 136 18729 10659 4609468
Bradycardia 275.21 42.46 174 18691 22395 4597732
Developmental delay 271.07 42.46 74 18791 1037 4619090
Rhabdomyolysis 264.31 42.46 161 18704 19397 4600730
Hypotonia 264.01 42.46 96 18769 3550 4616577
Drug withdrawal syndrome neonatal 263.20 42.46 80 18785 1672 4618455
Exposure during pregnancy 257.18 42.46 193 18672 32778 4587349
Visceral congestion 247.55 42.46 49 18816 133 4619994
Insomnia 246.72 42.46 215 18650 45130 4574997
Treatment noncompliance 243.52 42.46 129 18736 11898 4608229
Drug use disorder 238.21 42.46 65 18800 909 4619218
Condition aggravated 224.64 42.46 228 18637 57943 4562184
Maternal exposure during pregnancy 224.01 42.46 138 18727 16955 4603172
Serotonin syndrome 220.06 42.46 102 18763 7050 4613077
Schizophrenia 216.78 42.46 84 18781 3711 4616416
Apnoea 215.74 42.46 80 18785 3128 4616999
Hyperhidrosis 213.21 42.46 166 18699 29751 4590376
Metabolic acidosis 211.85 42.46 119 18746 12321 4607806
Brain oedema 210.58 42.46 88 18777 4739 4615388
Hallucination 209.80 42.46 134 18731 17534 4602593
Alcohol poisoning 208.47 42.46 58 18807 875 4619252
Mydriasis 206.32 42.46 81 18784 3707 4616420
Status epilepticus 201.58 42.46 86 18779 4877 4615250
Sinus tachycardia 201.47 42.46 92 18773 6142 4613985
Respiratory distress 196.54 42.46 109 18756 11007 4609120
Extrapyramidal disorder 196.05 42.46 86 18779 5220 4614907
Strabismus 193.03 42.46 54 18811 832 4619295
Medication error 192.99 42.46 118 18747 14298 4605829
Toxic epidermal necrolysis 192.65 42.46 89 18776 6103 4614024
Respiratory failure 179.51 42.46 151 18714 30175 4589952
Drug screen positive 174.24 42.46 62 18803 2150 4617977
Memory impairment 173.76 42.46 126 18739 20277 4599850
Alcohol abuse 173.47 42.46 51 18814 946 4619181
Drug diversion 171.61 42.46 45 18820 535 4619592
Respiratory acidosis 168.84 42.46 56 18809 1565 4618562
Salivary hypersecretion 167.71 42.46 65 18800 2872 4617255
Hepatocellular injury 166.31 42.46 87 18778 7813 4612314
Psychomotor hyperactivity 164.88 42.46 71 18794 4118 4616009
Tremor 163.88 42.46 155 18710 36104 4584023
Ataxia 160.17 42.46 75 18790 5302 4614825
Blood creatine phosphokinase increased 158.42 42.46 106 18759 14993 4605134
Circulatory collapse 156.13 42.46 83 18782 7702 4612425
Hypoxia 154.46 42.46 99 18766 13022 4607105
Encephalopathy 152.50 42.46 89 18776 9898 4610229
Cholestasis 151.98 42.46 82 18783 7838 4612289
Syncope 151.36 42.46 143 18722 33252 4586875
Gait disturbance 151.20 42.46 149 18716 36491 4583636
Arteriosclerosis coronary artery 145.82 42.46 60 18805 3104 4617023
Lethargy 145.71 42.46 106 18759 17135 4602992
Psychomotor skills impaired 144.84 42.46 43 18822 826 4619301
Hypoxic-ischaemic encephalopathy 140.91 42.46 50 18815 1719 4618408
Snoring 138.46 42.46 43 18822 967 4619160
Dystonia 138.03 42.46 65 18800 4653 4615474
Logorrhoea 137.72 42.46 43 18822 985 4619142
Catatonia 137.11 42.46 50 18815 1862 4618265
Off label use 135.68 42.46 271 18594 128842 4491285
Mental status changes 134.93 42.46 89 18776 12287 4607840
Cardiomegaly 134.72 42.46 65 18800 4912 4615215
Drug level increased 134.52 42.46 70 18795 6216 4613911
Hepatic steatosis 132.26 42.46 69 18796 6159 4613968
Psychomotor retardation 126.29 42.46 41 18824 1069 4619058
Self-medication 125.40 42.46 43 18822 1333 4618794
Product use issue 124.63 42.46 113 18752 24923 4595204
Dizziness 123.83 42.46 225 18640 99646 4520481
Generalised tonic-clonic seizure 123.25 42.46 78 18787 10032 4610095
Malaise 123.22 42.46 212 18653 89945 4530182
Urinary retention 122.62 42.46 77 18788 9770 4610357
Accidental poisoning 120.49 42.46 31 18834 340 4619787
Acute kidney injury 119.89 42.46 183 18682 70248 4549879
Oxygen saturation decreased 119.72 42.46 87 18778 14034 4606093
Amnesia 119.65 42.46 84 18781 12837 4607290
Myoclonus 117.04 42.46 60 18805 5164 4614963
Speech disorder 116.08 42.46 79 18786 11483 4608644
Asthenia 115.63 42.46 201 18664 85962 4534165
Pneumonia 115.43 42.46 222 18643 102593 4517534
Balance disorder 115.28 42.46 90 18775 16166 4603961
Suicidal behaviour 113.92 42.46 37 18828 966 4619161
Self-injurious ideation 113.42 42.46 37 18828 980 4619147
Accident 113.31 42.46 43 18822 1792 4618335
Sinus bradycardia 112.30 42.46 55 18810 4294 4615833
Muscle rigidity 110.73 42.46 53 18812 3934 4616193
Sudden death 109.93 42.46 58 18807 5297 4614830
Hyperthermia 108.94 42.46 50 18815 3374 4616753
Alcohol use 107.80 42.46 39 18826 1419 4618708
Bradykinesia 106.75 42.46 37 18828 1185 4618942
Parkinsonism 105.34 42.46 48 18817 3185 4616942
Optic nerve hypoplasia 104.51 42.46 19 18846 26 4620101
Visual acuity reduced 104.18 42.46 70 18795 9960 4610167
Stevens-Johnson syndrome 101.20 42.46 65 18800 8574 4611553
Stupor 100.62 42.46 37 18828 1411 4618716
Pyrexia 99.64 42.46 214 18651 106930 4513197
Tachypnoea 97.44 42.46 52 18813 4859 4615268
Cyanosis 93.79 42.46 55 18810 6167 4613960
Hypertension 93.55 42.46 137 18728 50661 4569466
Alcohol interaction 92.76 42.46 29 18836 667 4619460
Delusion 91.99 42.46 49 18816 4561 4615566
Tension 91.87 42.46 31 18834 914 4619213
Mental disorder 91.51 42.46 58 18807 7476 4612651
Heart rate increased 90.91 42.46 83 18782 18459 4601668
Respiratory disorder 89.07 42.46 58 18807 7830 4612297
Nausea 86.35 42.46 278 18587 177055 4443072
Multiple organ dysfunction syndrome 86.23 42.46 81 18784 18675 4601452
Irritability 84.40 42.46 69 18796 13230 4606897
Premature baby 83.09 42.46 61 18804 9990 4610137
Social avoidant behaviour 82.53 42.46 31 18834 1255 4618872
Nightmare 82.18 42.46 53 18812 7037 4613090
Headache 81.83 42.46 215 18650 122158 4497969
Respiratory rate decreased 80.92 42.46 29 18836 1026 4619101
Depressed mood 80.71 42.46 57 18808 8787 4611340
Cognitive disorder 78.59 42.46 60 18805 10421 4609706
Thinking abnormal 78.43 42.46 40 18825 3404 4616723
Muscle spasms 77.65 42.46 104 18761 35386 4584741
Myocardial fibrosis 77.45 42.46 21 18844 286 4619841
Microcephaly 76.59 42.46 23 18842 460 4619667
Apathy 76.39 42.46 37 18828 2818 4617309
Dyskinesia 76.01 42.46 56 18809 9219 4610908
Drowning 75.08 42.46 21 18844 323 4619804
Drug reaction with eosinophilia and systemic symptoms 74.81 42.46 61 18804 11652 4608475
Hyponatraemia 74.28 42.46 85 18780 24645 4595482
Blood pressure decreased 74.15 42.46 73 18792 17827 4602300
Incorrect route of product administration 73.80 42.46 60 18805 11413 4608714
Hypokalaemia 73.09 42.46 74 18791 18686 4601441
Sleep disorder 72.65 42.46 59 18806 11204 4608923
Rhesus incompatibility 72.28 42.46 13 18852 16 4620111
Akathisia 71.65 42.46 38 18827 3505 4616622
Blister 71.53 42.46 59 18806 11450 4608677
Movement disorder 71.38 42.46 42 18823 4737 4615390
Hypoventilation 71.27 42.46 28 18837 1282 4618845
Toxicologic test abnormal 71.24 42.46 20 18845 312 4619815
Pancreatic fibrosis 70.21 42.46 12 18853 8 4620119
Acidosis 70.21 42.46 37 18828 3369 4616758
Apgar score low 70.00 42.46 23 18842 623 4619504
Fatigue 69.69 42.46 227 18638 145339 4474788
Road traffic accident 69.42 42.46 51 18814 8358 4611769
Dehydration 69.23 42.46 108 18757 42182 4577945
Pain 69.14 42.46 170 18695 92700 4527427
Electrocardiogram J wave 68.54 42.46 12 18853 11 4620116
Feeling abnormal 68.17 42.46 99 18766 36306 4583821
Epilepsy 68.12 42.46 53 18812 9465 4610662
Atrioventricular septal defect 67.76 42.46 17 18848 167 4619960
Potentiating drug interaction 67.22 42.46 28 18837 1493 4618634
Arrhythmia 66.77 42.46 61 18804 13571 4606556
Toxic encephalopathy 66.31 42.46 29 18836 1745 4618382
Musculoskeletal stiffness 65.45 42.46 70 18795 18832 4601295
Mood swings 65.40 42.46 42 18823 5535 4614592
Strabismus congenital 64.53 42.46 14 18851 67 4620060
Hyperkalaemia 64.50 42.46 64 18801 15773 4604354
Brain injury 64.14 42.46 30 18835 2113 4618014
Homicide 63.52 42.46 20 18845 471 4619656
Physical assault 63.43 42.46 21 18844 583 4619544
Hypercapnia 63.42 42.46 25 18840 1155 4618972
Somnambulism 63.17 42.46 28 18837 1740 4618387
Maternal drugs affecting foetus 62.27 42.46 36 18829 3929 4616198
Incoherent 62.24 42.46 28 18837 1802 4618325
Left ventricular hypertrophy 61.73 42.46 27 18838 1625 4618502
Hypoglycaemia 61.68 42.46 67 18798 18342 4601785
Mania 61.57 42.46 39 18826 5019 4615108
Spleen congestion 61.48 42.46 15 18850 130 4619997
Septic shock 61.45 42.46 64 18801 16702 4603425
Hepatic congestion 61.05 42.46 21 18844 657 4619470
Agranulocytosis 60.73 42.46 45 18820 7472 4612655
Dyspnoea 60.53 42.46 210 18655 138775 4481352
Aphasia 60.42 42.46 48 18817 8832 4611295
Dysmorphism 59.82 42.46 23 18842 993 4619134
Antipsychotic drug level increased 59.74 42.46 25 18840 1349 4618778
Hypotonia neonatal 58.78 42.46 20 18845 605 4619522
Bradycardia foetal 58.18 42.46 17 18848 308 4619819
Sleep apnoea syndrome 57.97 42.46 36 18829 4475 4615652
Visual impairment 56.94 42.46 66 18799 19394 4600733
Panic attack 56.85 42.46 40 18825 6127 4614000
Hypersomnia 56.79 42.46 35 18830 4292 4615835
Hepatitis 56.64 42.46 53 18812 12152 4607975
Muscle spasticity 56.61 42.46 32 18833 3346 4616781
Dysphagia 56.10 42.46 75 18790 25456 4594671
Intentional product use issue 56.04 42.46 42 18823 7093 4613034
Hyporeflexia 55.93 42.46 21 18844 849 4619278
Hypernatraemia 55.84 42.46 27 18838 2048 4618079
Obstructive airways disorder 55.54 42.46 29 18836 2591 4617536
Blood pH decreased 55.49 42.46 22 18843 1032 4619095
Cholecystitis 55.41 42.46 34 18831 4137 4615990
Quadriparesis 55.40 42.46 19 18846 589 4619538
Renal impairment 55.02 42.46 74 18791 25264 4594863
Renal failure 54.72 42.46 96 18769 41273 4578854
Patient restraint 54.07 42.46 10 18855 16 4620111
Judgement impaired 54.05 42.46 16 18849 304 4619823
Coordination abnormal 54.05 42.46 32 18833 3650 4616477
Dissociation 53.61 42.46 20 18845 794 4619333
Hallucinations, mixed 53.47 42.46 22 18843 1137 4618990
Foetal death 53.39 42.46 28 18837 2524 4617603
Acute respiratory failure 53.38 42.46 39 18826 6337 4613790
Bradycardia neonatal 53.23 42.46 18 18847 534 4619593
Nervous system disorder 53.08 42.46 39 18826 6392 4613735
Emotional disorder 53.03 42.46 31 18834 3454 4616673
Infantile apnoea 53.01 42.46 18 18847 541 4619586
Aspartate aminotransferase increased 52.88 42.46 72 18793 24866 4595261
Vestibular disorder 52.88 42.46 17 18848 429 4619698
Incontinence 52.86 42.46 28 18837 2576 4617551
Areflexia 52.66 42.46 22 18843 1182 4618945
Hyporesponsive to stimuli 52.10 42.46 16 18849 346 4619781
Purpura senile 51.10 42.46 10 18855 25 4620102
Victim of child abuse 51.10 42.46 10 18855 25 4620102
Initial insomnia 50.98 42.46 22 18843 1281 4618846
Bezoar 50.65 42.46 16 18849 381 4619746
Urinary incontinence 50.44 42.46 40 18825 7340 4612787
Electrolyte imbalance 50.33 42.46 31 18834 3798 4616329
Selective eating disorder 50.21 42.46 20 18845 950 4619177
Therapeutic product cross-reactivity 50.19 42.46 19 18846 786 4619341
Crystalluria 50.08 42.46 13 18852 148 4619979
Dependence 49.89 42.46 19 18846 799 4619328
Cholelithiasis 49.84 42.46 44 18821 9358 4610769
Anterograde amnesia 49.77 42.46 14 18851 220 4619907
Cleft palate 49.30 42.46 18 18847 672 4619455
Leukocytosis 49.25 42.46 40 18825 7594 4612533
Device malfunction 48.96 42.46 37 18828 6327 4613800
Affective disorder 48.23 42.46 23 18842 1692 4618435
Injury 48.19 42.46 43 18822 9275 4610852
Hypokinesia 48.03 42.46 28 18837 3103 4617024
Blood sodium decreased 47.90 42.46 35 18830 5687 4614440
Arteriosclerosis 47.90 42.46 29 18836 3445 4616682
Paradoxical drug reaction 47.69 42.46 20 18845 1085 4619042
Autonomic nervous system imbalance 47.57 42.46 19 18846 909 4619218
Priapism 47.24 42.46 22 18843 1534 4618593
Needle track marks 46.96 42.46 10 18855 43 4620084
Therapy non-responder 46.42 42.46 54 18811 15923 4604204
Product use in unapproved indication 46.24 42.46 68 18797 25205 4594922
Eating disorder 46.07 42.46 29 18836 3691 4616436
PO2 increased 45.93 42.46 14 18851 295 4619832
Blood lactic acid increased 45.51 42.46 23 18842 1919 4618208
Myocarditis 45.51 42.46 28 18837 3423 4616704
Oral discharge 45.43 42.46 11 18854 92 4620035
Hallucination, auditory 45.37 42.46 31 18834 4530 4615597
Mucosal erosion 45.32 42.46 15 18850 416 4619711
Gallbladder cholesterolosis 45.20 42.46 12 18853 150 4619977
Maternal exposure timing unspecified 45.17 42.46 17 18848 692 4619435
Weight decreased 45.12 42.46 104 18761 54360 4565767
Hypercapnic coma 44.93 42.46 10 18855 55 4620072
Neonatal respiratory distress syndrome 44.88 42.46 22 18843 1719 4618408
Hyperlactacidaemia 44.73 42.46 18 18847 878 4619249
Prescription form tampering 44.53 42.46 14 18851 328 4619799
Decreased appetite 43.79 42.46 105 18760 56292 4563835
Drug detoxification 43.76 42.46 11 18854 109 4620018
Muscular weakness 43.69 42.46 68 18797 26482 4593645
Necrotising colitis 43.68 42.46 16 18849 603 4619524
Body temperature increased 43.46 42.46 34 18831 6118 4614009
White blood cell count increased 43.36 42.46 51 18814 15216 4604911
Inappropriate antidiuretic hormone secretion 43.29 42.46 30 18835 4484 4615643
Choking 43.27 42.46 25 18840 2724 4617403
Psychotic symptom 43.19 42.46 15 18850 483 4619644
Bladder dilatation 43.19 42.46 14 18851 363 4619764
Osmolar gap abnormal 43.18 42.46 8 18857 13 4620114
Mood altered 43.15 42.46 32 18833 5317 4614810
Hypertonia 42.75 42.46 25 18840 2787 4617340
Victim of chemical submission 42.74 42.46 10 18855 71 4620056
Hyperchloraemia 42.70 42.46 12 18853 188 4619939
Incorrect dose administered 42.67 42.46 57 18808 19328 4600799

Pharmacologic Action:

SourceCodeDescription
ATC N05BA01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
MeSH PA D000759 Adjuvants, Anesthesia
MeSH PA D000777 Anesthetics
MeSH PA D018686 Anesthetics, Intravenous
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35717 sedative
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000927 Anticonvulsants
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D009125 Muscle Relaxants, Central
MeSH PA D009465 Neuromuscular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
FDA EPC N0000175694 Benzodiazepine
FDA CS M0002356 Benzodiazepines
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Alcohol withdrawal delirium indication 8635005
Anxiety indication 48694002
Sedation indication 72641008
Tetanus indication 76902006 DOID:11338
Epilepsy indication 84757009 DOID:1826
Alcohol withdrawal syndrome indication 191480000
Spasticity indication 221360009
Status epilepticus indication 230456007 DOID:1824
Induce Anterograde Amnesia indication
Preoperative Anxiety indication
Panic disorder off-label use 371631005 DOID:594
Cocaine-Associated Acute Ischemic Heart Disease off-label use
Disorder of lung contraindication 19829001 DOID:850
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Myasthenia gravis contraindication 91637004 DOID:437
Hypoalbuminemia contraindication 119247004
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.06 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 8927497 July 21, 2025 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 8927497 July 21, 2025 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 8927497 July 21, 2025 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 9763876 March 27, 2029 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 9763876 March 27, 2029 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 9763876 March 27, 2029 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2023 NEW PRODUCT
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2023 NEW PRODUCT
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2023 NEW PRODUCT
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.14 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.85 WOMBAT-PK CHEMBL
GABA-A receptor alpha-2/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.70 WOMBAT-PK CHEMBL
GABA A receptor alpha-3/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.94 WOMBAT-PK CHEMBL
GABA-A receptor alpha-5/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.96 WOMBAT-PK CHEMBL
GABA A receptor alpha-5/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 8.00 WOMBAT-PK CHEMBL
GABA A receptor alpha-5/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.20 WOMBAT-PK CHEMBL
GABA A receptor alpha-5/beta-3/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.20 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 6.71 WOMBAT-PK CHEMBL
GABA A receptor alpha-3/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 6.67 WOMBAT-PK CHEMBL
GABA-A receptor alpha-3/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.65 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme Ki 4.42 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR ALLOSTERIC MODULATOR Ki 4.10 IUPHAR
Gamma-aminobutyric acid receptor subunit alpha-5 Ion channel Kd 7.64 CHEMBL
Adenosine receptor A3 GPCR IC50 7.92 CHEMBL
Translocator protein Membrane receptor Kd 6.67 CHEMBL
Cholinesterase Enzyme Ki 7.37 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 8.54 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 4.07 CHEMBL
GABA A receptor alpha-2/beta-2/gamma-2 Ion channel Ki 7.70 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-2 Ion channel Ki 7.82 CHEMBL
Thyrotropin-releasing hormone receptor GPCR ANTAGONIST Ki 5.15 IUPHAR
GABA-A receptor; alpha-1/beta-2/gamma-2 Ion channel Ki 7.92 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-1 Ion channel Ki 7.96 CHEMBL
Fatty acid-binding protein, liver Unclassified Ki 6.27 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-5 Ion channel Ki 8.01 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 8 CHEMBL
GABA A receptor alpha-3/beta-2/gamma-2 Ion channel Ki 7.86 CHEMBL
Acetylcholinesterase Enzyme Ki 4.89 CHEMBL
GABA A receptor alpha-5/beta-3/gamma-2 Ion channel Ki 7.96 CHEMBL
GABA A receptor alpha-6/beta-2/gamma-2 Ion channel Ki 8.68 CHEMBL

External reference:

IDSource
D003975 MESH_DESCRIPTOR_UI
4017796 VUID
N0000146157 NUI
C0012010 UMLSCUI
D00293 KEGG_DRUG
387264003 SNOMEDCT_US
4573 MMSL
48546005 SNOMEDCT_US
4017796 VANDF
3322 RXNORM
001461 NDDF
d00148 MMSL
894 MMSL
CHEBI:49575 CHEBI
CHEMBL12 ChEMBL_ID
DB00829 DRUGBANK_ID
Q3JTX2Q7TU UNII
1295 INN_ID
3364 IUPHAR_LIGAND_ID
3016 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Diazepam Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3185 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 13 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3188 SOLUTION 5 mg ORAL ANDA 13 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-6137 GEL 2.50 mg RECTAL NDA authorized generic 13 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-6138 GEL 10 mg RECTAL NDA authorized generic 13 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-6139 GEL 20 mg RECTAL NDA authorized generic 13 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0004 TABLET 2 mg ORAL NDA 15 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0005 TABLET 5 mg ORAL NDA 15 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0006 TABLET 10 mg ORAL NDA 15 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3925 TABLET 2 mg ORAL ANDA 14 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3926 TABLET 5 mg ORAL ANDA 14 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3927 TABLET 10 mg ORAL ANDA 14 sections
Diastat HUMAN PRESCRIPTION DRUG LABEL 1 0187-0658 GEL 10 mg RECTAL NDA 14 sections
Diastat HUMAN PRESCRIPTION DRUG LABEL 1 0187-0659 GEL 20 mg RECTAL NDA 14 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0271 TABLET 2 mg ORAL ANDA 14 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0345 TABLET 5 mg ORAL ANDA 14 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0477 TABLET 10 mg ORAL ANDA 14 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-1273 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 15 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0409-3213 INJECTION, SOLUTION 5 mg INTRAMUSCULAR ANDA 13 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0527-1767 SOLUTION 5 mg ORAL ANDA 12 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0527-1768 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 12 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7799 TABLET 5 mg ORAL ANDA 14 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7800 TABLET 10 mg ORAL ANDA 12 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8049 TABLET 5 mg ORAL ANDA 12 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0904-5880 TABLET 5 mg ORAL ANDA 15 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 10544-161 TABLET 10 mg ORAL ANDA 14 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 11704-600 INJECTION 10 mg INTRAMUSCULAR NDA 14 sections
DIAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 12634-529 TABLET 5 mg ORAL ANDA 14 sections
DIAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 12634-698 TABLET 10 mg ORAL ANDA 14 sections
DIAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-069 TABLET 2 mg ORAL ANDA 14 sections
DIAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-070 TABLET 5 mg ORAL ANDA 14 sections