clorazepate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| diazepam derivatives | 711 | 57109-90-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A water-soluble benzodiazepine derivative effective in the treatment of anxiety. It has also muscle relaxant and anticonvulsant actions.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 20 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 5.45 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 91 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.20 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 2.40 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 100 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 23, 1972 | FDA | RECORDATI RARE |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Coma | 224.61 | 17.88 | 133 | 9521 | 64231 | 63415137 |
| Suicide attempt | 112.97 | 17.88 | 85 | 9569 | 60833 | 63418535 |
| Coma blister | 107.59 | 17.88 | 19 | 9635 | 141 | 63479227 |
| Somnolence | 93.44 | 17.88 | 125 | 9529 | 178560 | 63300808 |
| Drug abuse | 78.11 | 17.88 | 74 | 9580 | 72444 | 63406924 |
| Disorientation | 75.22 | 17.88 | 56 | 9598 | 39396 | 63439972 |
| Seizure | 71.14 | 17.88 | 94 | 9560 | 132540 | 63346828 |
| Erythrodermic psoriasis | 67.78 | 17.88 | 18 | 9636 | 1000 | 63478368 |
| Neurological decompensation | 66.53 | 17.88 | 22 | 9632 | 2616 | 63476752 |
| Poisoning deliberate | 66.52 | 17.88 | 33 | 9621 | 11185 | 63468183 |
| Toxic epidermal necrolysis | 64.67 | 17.88 | 43 | 9611 | 25291 | 63454077 |
| Rhabdomyolysis | 61.48 | 17.88 | 52 | 9602 | 43899 | 63435469 |
| Drug interaction | 61.15 | 17.88 | 118 | 9536 | 229013 | 63250355 |
| Tissue infiltration | 60.94 | 17.88 | 15 | 9639 | 614 | 63478754 |
| Overdose | 60.83 | 17.88 | 81 | 9573 | 114997 | 63364371 |
| Basal ganglion degeneration | 60.64 | 17.88 | 14 | 9640 | 434 | 63478934 |
| Dermatitis exfoliative | 57.60 | 17.88 | 24 | 9630 | 5435 | 63473933 |
| Fall | 57.04 | 17.88 | 159 | 9495 | 392175 | 63087193 |
| Antithrombin III | 55.81 | 17.88 | 11 | 9643 | 156 | 63479212 |
| Behaviour disorder | 51.14 | 17.88 | 19 | 9635 | 3180 | 63476188 |
| Uterine enlargement | 50.52 | 17.88 | 15 | 9639 | 1253 | 63478115 |
| Stupor | 49.20 | 17.88 | 20 | 9634 | 4255 | 63475113 |
| Hyperventilation | 48.55 | 17.88 | 22 | 9632 | 6094 | 63473274 |
| Monoplegia | 47.49 | 17.88 | 18 | 9636 | 3183 | 63476185 |
| Euphoric mood | 46.62 | 17.88 | 20 | 9634 | 4867 | 63474501 |
| Anaesthesia | 45.32 | 17.88 | 11 | 9643 | 424 | 63478944 |
| Intentional overdose | 45.13 | 17.88 | 56 | 9598 | 74096 | 63405272 |
| Hyperthyroidism | 45.10 | 17.88 | 28 | 9626 | 14645 | 63464723 |
| Toxicity to various agents | 44.89 | 17.88 | 109 | 9545 | 247141 | 63232227 |
| Depressed level of consciousness | 44.56 | 17.88 | 51 | 9603 | 62027 | 63417341 |
| Electrolyte imbalance | 43.95 | 17.88 | 31 | 9623 | 20045 | 63459323 |
| Inguinal hernia | 43.74 | 17.88 | 15 | 9639 | 1992 | 63477376 |
| Loss of consciousness | 43.32 | 17.88 | 70 | 9584 | 118051 | 63361317 |
| Multiple organ dysfunction syndrome | 43.08 | 17.88 | 48 | 9606 | 56704 | 63422664 |
| Psychogenic seizure | 42.22 | 17.88 | 14 | 9640 | 1678 | 63477690 |
| Drug monitoring procedure incorrectly performed | 36.30 | 17.88 | 8 | 9646 | 200 | 63479168 |
| Psychomotor hyperactivity | 34.43 | 17.88 | 21 | 9633 | 10642 | 63468726 |
| Cholecystitis | 34.25 | 17.88 | 24 | 9630 | 15353 | 63464015 |
| Joint swelling | 33.43 | 17.88 | 5 | 9649 | 327661 | 63151707 |
| Hypochromic anaemia | 32.76 | 17.88 | 12 | 9642 | 1930 | 63477438 |
| Drug dependence | 32.25 | 17.88 | 28 | 9626 | 24455 | 63454913 |
| Delusion | 32.12 | 17.88 | 21 | 9633 | 11996 | 63467372 |
| Dysaesthesia | 32.08 | 17.88 | 15 | 9639 | 4463 | 63474905 |
| Neuroleptic malignant syndrome | 32.06 | 17.88 | 21 | 9633 | 12035 | 63467333 |
| Sudden cardiac death | 31.62 | 17.88 | 12 | 9642 | 2128 | 63477240 |
| Klebsiella infection | 30.59 | 17.88 | 18 | 9636 | 8548 | 63470820 |
| Granulomatous liver disease | 30.11 | 17.88 | 9 | 9645 | 769 | 63478599 |
| Intra-abdominal haematoma | 29.88 | 17.88 | 11 | 9643 | 1794 | 63477574 |
| Mydriasis | 29.80 | 17.88 | 20 | 9634 | 11936 | 63467432 |
| Urinary retention | 28.99 | 17.88 | 29 | 9625 | 30272 | 63449096 |
| Anterograde amnesia | 28.62 | 17.88 | 8 | 9646 | 539 | 63478829 |
| Intervertebral disc disorder | 27.98 | 17.88 | 14 | 9640 | 4829 | 63474539 |
| Eosinophilia | 27.92 | 17.88 | 25 | 9629 | 22731 | 63456637 |
| Drug withdrawal syndrome | 27.82 | 17.88 | 27 | 9627 | 27167 | 63452201 |
| Social avoidant behaviour | 27.75 | 17.88 | 12 | 9642 | 2976 | 63476392 |
| Serotonin syndrome | 26.61 | 17.88 | 27 | 9627 | 28655 | 63450713 |
| Abdominal discomfort | 26.41 | 17.88 | 8 | 9646 | 320877 | 63158491 |
| Respiratory disorder | 26.18 | 17.88 | 31 | 9623 | 39051 | 63440317 |
| Derailment | 26.14 | 17.88 | 5 | 9649 | 60 | 63479308 |
| Confusional state | 25.98 | 17.88 | 87 | 9567 | 236293 | 63243075 |
| Tremor | 25.78 | 17.88 | 60 | 9594 | 132179 | 63347189 |
| Drug ineffective | 25.72 | 17.88 | 78 | 9576 | 1044687 | 62434681 |
| Hyperpyrexia | 25.50 | 17.88 | 12 | 9642 | 3620 | 63475748 |
| Rash | 25.17 | 17.88 | 29 | 9625 | 560842 | 62918526 |
| Disturbance in attention | 25.10 | 17.88 | 30 | 9624 | 38159 | 63441209 |
| Intestinal villi atrophy | 24.41 | 17.88 | 6 | 9648 | 244 | 63479124 |
| Hyperammonaemia | 24.12 | 17.88 | 13 | 9641 | 5219 | 63474149 |
| Abdominal tenderness | 23.63 | 17.88 | 15 | 9639 | 8151 | 63471217 |
| Somatic delusion | 23.57 | 17.88 | 7 | 9647 | 585 | 63478783 |
| Livedo reticularis | 23.35 | 17.88 | 10 | 9644 | 2422 | 63476946 |
| Catatonia | 23.12 | 17.88 | 12 | 9642 | 4465 | 63474903 |
| Pain | 23.05 | 17.88 | 49 | 9605 | 740579 | 62738789 |
| Arthropathy | 23.00 | 17.88 | 4 | 9650 | 234788 | 63244580 |
| Conversion disorder | 22.89 | 17.88 | 9 | 9645 | 1755 | 63477613 |
| Transaminases increased | 22.89 | 17.88 | 26 | 9628 | 31341 | 63448027 |
| Swelling | 22.42 | 17.88 | 7 | 9647 | 275371 | 63203997 |
| Hyponatraemia | 22.06 | 17.88 | 51 | 9603 | 111849 | 63367519 |
| Alopecia | 21.97 | 17.88 | 12 | 9642 | 337524 | 63141844 |
| Cyanosis | 21.56 | 17.88 | 19 | 9635 | 16916 | 63462452 |
| Nasopharyngitis | 21.54 | 17.88 | 6 | 9648 | 254251 | 63225117 |
| Suicidal ideation | 21.52 | 17.88 | 36 | 9618 | 62385 | 63416983 |
| Neonatal aspiration | 21.50 | 17.88 | 5 | 9649 | 160 | 63479208 |
| Cutaneous vasculitis | 21.29 | 17.88 | 12 | 9642 | 5257 | 63474111 |
| Hypersensitivity | 21.19 | 17.88 | 9 | 9645 | 292676 | 63186692 |
| Regressive behaviour | 20.88 | 17.88 | 5 | 9649 | 182 | 63479186 |
| Renal cyst | 20.46 | 17.88 | 15 | 9639 | 10287 | 63469081 |
| Lung disorder | 20.26 | 17.88 | 35 | 9619 | 62226 | 63417142 |
| Colitis ischaemic | 19.95 | 17.88 | 15 | 9639 | 10693 | 63468675 |
| Shock | 19.81 | 17.88 | 21 | 9633 | 23442 | 63455926 |
| Hyperthermia | 19.71 | 17.88 | 14 | 9640 | 9142 | 63470226 |
| Dysarthria | 19.43 | 17.88 | 28 | 9626 | 42683 | 63436685 |
| Irritability | 19.37 | 17.88 | 24 | 9630 | 31670 | 63447698 |
| Renal failure | 19.33 | 17.88 | 50 | 9604 | 117602 | 63361766 |
| Withdrawal syndrome | 18.87 | 17.88 | 19 | 9635 | 19978 | 63459390 |
| Hepatocellular injury | 18.80 | 17.88 | 22 | 9632 | 27359 | 63452009 |
| Fatigue | 18.61 | 17.88 | 71 | 9583 | 887957 | 62591411 |
| Infection | 18.34 | 17.88 | 6 | 9648 | 229167 | 63250201 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Coma | 145.12 | 18.42 | 89 | 5256 | 45589 | 34905997 |
| Hepatitis acute | 72.04 | 18.42 | 31 | 5314 | 7570 | 34944016 |
| Somnolence | 47.80 | 18.42 | 71 | 5274 | 111045 | 34840541 |
| Anticoagulation drug level above therapeutic | 46.76 | 18.42 | 16 | 5329 | 2100 | 34949486 |
| Wrong patient | 44.49 | 18.42 | 9 | 5336 | 146 | 34951440 |
| Stevens-Johnson syndrome | 43.54 | 18.42 | 30 | 5315 | 18609 | 34932977 |
| Toxic epidermal necrolysis | 41.73 | 18.42 | 31 | 5314 | 21615 | 34929971 |
| Wrong patient received product | 39.58 | 18.42 | 15 | 5330 | 2639 | 34948947 |
| Tachycardia | 37.62 | 18.42 | 55 | 5290 | 84717 | 34866869 |
| Aggression | 36.62 | 18.42 | 37 | 5308 | 38927 | 34912659 |
| Pneumonia aspiration | 36.15 | 18.42 | 38 | 5307 | 41865 | 34909721 |
| Acute respiratory distress syndrome | 34.70 | 18.42 | 30 | 5315 | 25939 | 34925647 |
| Cor pulmonale acute | 33.95 | 18.42 | 8 | 5337 | 270 | 34951316 |
| Prothrombin level decreased | 30.78 | 18.42 | 10 | 5335 | 1118 | 34950468 |
| Extrapyramidal disorder | 30.71 | 18.42 | 21 | 5324 | 12859 | 34938727 |
| Faecal vomiting | 30.26 | 18.42 | 8 | 5337 | 434 | 34951152 |
| Rhabdomyolysis | 29.90 | 18.42 | 44 | 5301 | 68119 | 34883467 |
| Agitation | 28.03 | 18.42 | 39 | 5306 | 57360 | 34894226 |
| Restlessness | 27.29 | 18.42 | 26 | 5319 | 25456 | 34926130 |
| Dyspnoea | 26.98 | 18.42 | 12 | 5333 | 376770 | 34574816 |
| Pancreatitis acute | 26.94 | 18.42 | 27 | 5318 | 28114 | 34923472 |
| Drug interaction | 26.32 | 18.42 | 85 | 5260 | 225861 | 34725725 |
| Asphyxia | 26.02 | 18.42 | 15 | 5330 | 6820 | 34944766 |
| Dermatitis bullous | 25.85 | 18.42 | 15 | 5330 | 6907 | 34944679 |
| Toxic skin eruption | 25.81 | 18.42 | 18 | 5327 | 11367 | 34940219 |
| Blister | 25.78 | 18.42 | 24 | 5321 | 22834 | 34928752 |
| Sedation | 25.53 | 18.42 | 23 | 5322 | 20983 | 34930603 |
| Overdose | 25.44 | 18.42 | 48 | 5297 | 91011 | 34860575 |
| Clonus | 25.34 | 18.42 | 11 | 5334 | 2739 | 34948847 |
| Mucosal erosion | 25.15 | 18.42 | 8 | 5337 | 836 | 34950750 |
| Abnormal behaviour | 23.98 | 18.42 | 24 | 5321 | 24945 | 34926641 |
| Lung disorder | 23.93 | 18.42 | 28 | 5317 | 34668 | 34916918 |
| Miosis | 23.81 | 18.42 | 16 | 5329 | 9519 | 34942067 |
| Hypothermia | 22.08 | 18.42 | 16 | 5329 | 10732 | 34940854 |
| Intestinal obstruction | 22.03 | 18.42 | 22 | 5323 | 22800 | 34928786 |
| Cardio-respiratory arrest | 21.84 | 18.42 | 34 | 5311 | 55239 | 34896347 |
| Urinary retention | 21.31 | 18.42 | 27 | 5318 | 36261 | 34915325 |
| Eosinophilia | 21.22 | 18.42 | 23 | 5322 | 26199 | 34925387 |
| Cytotoxic oedema | 21.01 | 18.42 | 5 | 5340 | 176 | 34951410 |
| Intentional product misuse | 20.79 | 18.42 | 30 | 5315 | 45581 | 34906005 |
| Intentional overdose | 20.31 | 18.42 | 29 | 5316 | 43645 | 34907941 |
| Electromyogram abnormal | 20.26 | 18.42 | 4 | 5341 | 57 | 34951529 |
| Disturbance in attention | 19.68 | 18.42 | 22 | 5323 | 25923 | 34925663 |
| Colitis ischaemic | 18.94 | 18.42 | 12 | 5333 | 6463 | 34945123 |
| Wrong product administered | 18.45 | 18.42 | 11 | 5334 | 5323 | 34946263 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Coma | 350.84 | 16.99 | 213 | 12793 | 100436 | 79630946 |
| Somnolence | 133.61 | 16.99 | 179 | 12827 | 238802 | 79492580 |
| Suicide attempt | 111.87 | 16.99 | 99 | 12907 | 82833 | 79648549 |
| Toxic epidermal necrolysis | 100.51 | 16.99 | 72 | 12934 | 44509 | 79686873 |
| Coma blister | 98.49 | 16.99 | 19 | 12987 | 222 | 79731160 |
| Disorientation | 74.94 | 16.99 | 70 | 12936 | 62706 | 79668676 |
| Poisoning deliberate | 73.62 | 16.99 | 43 | 12963 | 18785 | 79712597 |
| Rhabdomyolysis | 72.98 | 16.99 | 87 | 12919 | 103044 | 79628338 |
| Overdose | 72.40 | 16.99 | 117 | 12889 | 184089 | 79547293 |
| Drug interaction | 71.22 | 16.99 | 187 | 12819 | 414996 | 79316386 |
| Intentional overdose | 63.12 | 16.99 | 82 | 12924 | 105878 | 79625504 |
| Drug abuse | 62.10 | 16.99 | 102 | 12904 | 162589 | 79568793 |
| Hepatitis acute | 62.10 | 16.99 | 36 | 12970 | 15506 | 79715876 |
| Neurological decompensation | 56.86 | 16.99 | 24 | 12982 | 5229 | 79726153 |
| Erythrodermic psoriasis | 56.81 | 16.99 | 18 | 12988 | 1740 | 79729642 |
| Stupor | 53.76 | 16.99 | 25 | 12981 | 6847 | 79724535 |
| Toxicity to various agents | 51.24 | 16.99 | 168 | 12838 | 421372 | 79310010 |
| Depressed level of consciousness | 50.23 | 16.99 | 70 | 12936 | 96582 | 79634800 |
| Basal ganglion degeneration | 49.29 | 16.99 | 12 | 12994 | 436 | 79730946 |
| Tissue infiltration | 48.84 | 16.99 | 13 | 12993 | 678 | 79730704 |
| Seizure | 48.76 | 16.99 | 100 | 12906 | 188734 | 79542648 |
| Aggression | 46.31 | 16.99 | 49 | 12957 | 50909 | 79680473 |
| Dermatitis exfoliative | 45.71 | 16.99 | 26 | 12980 | 10803 | 79720579 |
| Urinary retention | 45.45 | 16.99 | 51 | 12955 | 56579 | 79674803 |
| Uterine enlargement | 45.33 | 16.99 | 13 | 12993 | 895 | 79730487 |
| Disturbance in attention | 42.92 | 16.99 | 47 | 12959 | 50754 | 79680628 |
| Eosinophilia | 41.91 | 16.99 | 44 | 12962 | 45301 | 79686081 |
| Pneumonia aspiration | 41.70 | 16.99 | 53 | 12953 | 66914 | 79664468 |
| Euphoric mood | 39.36 | 16.99 | 21 | 12985 | 7705 | 79723677 |
| Monoplegia | 39.21 | 16.99 | 17 | 12989 | 3954 | 79727428 |
| Hyperventilation | 38.92 | 16.99 | 21 | 12985 | 7878 | 79723504 |
| Faecal vomiting | 38.37 | 16.99 | 12 | 12994 | 1112 | 79730270 |
| Fall | 38.23 | 16.99 | 169 | 12837 | 487460 | 79243922 |
| Anaesthesia | 37.66 | 16.99 | 10 | 12996 | 517 | 79730865 |
| Behaviour disorder | 37.43 | 16.99 | 19 | 12987 | 6294 | 79725088 |
| Neuroleptic malignant syndrome | 37.32 | 16.99 | 33 | 12973 | 27526 | 79703856 |
| Confusional state | 37.03 | 16.99 | 125 | 12881 | 317872 | 79413510 |
| Lung disorder | 36.95 | 16.99 | 55 | 12951 | 80502 | 79650880 |
| Drug dependence | 36.68 | 16.99 | 39 | 12967 | 40730 | 79690652 |
| Joint swelling | 35.89 | 16.99 | 3 | 13003 | 288643 | 79442739 |
| Psychogenic seizure | 35.69 | 16.99 | 13 | 12993 | 1918 | 79729464 |
| Colitis ischaemic | 35.04 | 16.99 | 25 | 12981 | 15334 | 79716048 |
| Hyperthyroidism | 34.97 | 16.99 | 29 | 12977 | 22180 | 79709202 |
| Drug withdrawal syndrome | 34.45 | 16.99 | 35 | 12971 | 34683 | 79696699 |
| Anticoagulation drug level above therapeutic | 34.12 | 16.99 | 15 | 12991 | 3605 | 79727777 |
| Prothrombin level decreased | 33.89 | 16.99 | 12 | 12994 | 1632 | 79729750 |
| Sedation | 32.19 | 16.99 | 41 | 12965 | 51854 | 79679528 |
| Miosis | 32.17 | 16.99 | 24 | 12982 | 15765 | 79715617 |
| Tachycardia | 31.32 | 16.99 | 81 | 12925 | 177687 | 79553695 |
| Anterograde amnesia | 30.54 | 16.99 | 9 | 12997 | 682 | 79730700 |
| Antithrombin III | 29.90 | 16.99 | 6 | 13000 | 87 | 79731295 |
| Drug monitoring procedure incorrectly performed | 29.05 | 16.99 | 8 | 12998 | 475 | 79730907 |
| Sudden cardiac death | 28.88 | 16.99 | 15 | 12991 | 5210 | 79726172 |
| Psychomotor skills impaired | 28.85 | 16.99 | 15 | 12991 | 5222 | 79726160 |
| Psychomotor hyperactivity | 28.63 | 16.99 | 23 | 12983 | 16826 | 79714556 |
| Cardio-respiratory arrest | 28.61 | 16.99 | 58 | 12948 | 108452 | 79622930 |
| Wrong patient received product | 27.68 | 16.99 | 14 | 12992 | 4604 | 79726778 |
| Intervertebral disc disorder | 27.10 | 16.99 | 14 | 12992 | 4811 | 79726571 |
| Fatigue | 27.01 | 16.99 | 71 | 12935 | 929656 | 78801726 |
| Wrong patient | 26.38 | 16.99 | 7 | 12999 | 361 | 79731021 |
| Shock | 26.37 | 16.99 | 34 | 12972 | 43514 | 79687868 |
| Irritability | 26.30 | 16.99 | 33 | 12973 | 41111 | 79690271 |
| Cor pulmonale acute | 26.16 | 16.99 | 8 | 12998 | 688 | 79730694 |
| Wrong product administered | 26.10 | 16.99 | 17 | 12989 | 8995 | 79722387 |
| Pancreatitis acute | 25.86 | 16.99 | 36 | 12970 | 49568 | 79681814 |
| Multiple organ dysfunction syndrome | 25.66 | 16.99 | 59 | 12947 | 120187 | 79611195 |
| Mydriasis | 25.64 | 16.99 | 22 | 12984 | 17621 | 79713761 |
| Electrolyte imbalance | 25.09 | 16.99 | 28 | 12978 | 30853 | 79700529 |
| Restlessness | 24.63 | 16.99 | 34 | 12972 | 46458 | 79684924 |
| Lymphocytosis | 24.59 | 16.99 | 13 | 12993 | 4680 | 79726702 |
| Derailment | 24.51 | 16.99 | 5 | 13001 | 79 | 79731303 |
| Social avoidant behaviour | 24.28 | 16.99 | 13 | 12993 | 4801 | 79726581 |
| Intra-abdominal haematoma | 24.12 | 16.99 | 11 | 12995 | 2880 | 79728502 |
| Loss of consciousness | 24.09 | 16.99 | 71 | 12935 | 167872 | 79563510 |
| Respiratory disorder | 24.06 | 16.99 | 33 | 12973 | 44823 | 79686559 |
| Serotonin syndrome | 23.96 | 16.99 | 33 | 12973 | 44994 | 79686388 |
| Agitation | 23.60 | 16.99 | 51 | 12955 | 99664 | 79631718 |
| Hyponatraemia | 23.46 | 16.99 | 73 | 12933 | 177775 | 79553607 |
| Livedo reticularis | 23.31 | 16.99 | 12 | 12994 | 4091 | 79727291 |
| Inguinal hernia | 23.22 | 16.99 | 14 | 12992 | 6474 | 79724908 |
| Cholecystitis | 23.15 | 16.99 | 23 | 12983 | 22189 | 79709193 |
| Mucosal erosion | 23.14 | 16.99 | 10 | 12996 | 2308 | 79729074 |
| Withdrawal syndrome | 22.94 | 16.99 | 25 | 12981 | 26829 | 79704553 |
| Delusion | 22.88 | 16.99 | 22 | 12984 | 20401 | 79710981 |
| Stevens-Johnson syndrome | 22.81 | 16.99 | 30 | 12976 | 39136 | 79692246 |
| Hypothermia | 22.69 | 16.99 | 23 | 12983 | 22723 | 79708659 |
| Pain | 22.57 | 16.99 | 51 | 12955 | 703751 | 79027631 |
| Dysaesthesia | 21.92 | 16.99 | 13 | 12993 | 5835 | 79725547 |
| Conversion disorder | 21.81 | 16.99 | 9 | 12997 | 1852 | 79729530 |
| Somatic delusion | 21.75 | 16.99 | 7 | 12999 | 711 | 79730671 |
| Metabolic acidosis | 21.61 | 16.99 | 44 | 12962 | 82485 | 79648897 |
| Electromyogram abnormal | 21.59 | 16.99 | 5 | 13001 | 146 | 79731236 |
| Hypochromic anaemia | 21.49 | 16.99 | 10 | 12996 | 2741 | 79728641 |
| Hepatocellular injury | 21.11 | 16.99 | 32 | 12974 | 47561 | 79683821 |
| Granulomatous liver disease | 21.06 | 16.99 | 8 | 12998 | 1325 | 79730057 |
| Extrapyramidal disorder | 20.94 | 16.99 | 22 | 12984 | 22657 | 79708725 |
| Regressive behaviour | 20.80 | 16.99 | 5 | 13001 | 172 | 79731210 |
| Peripheral swelling | 20.74 | 16.99 | 9 | 12997 | 269608 | 79461774 |
| Arthralgia | 20.37 | 16.99 | 39 | 12967 | 571764 | 79159618 |
| Nasopharyngitis | 20.30 | 16.99 | 8 | 12998 | 253873 | 79477509 |
| Intestinal villi atrophy | 20.25 | 16.99 | 6 | 13000 | 463 | 79730919 |
| Rash maculo-papular | 19.81 | 16.99 | 34 | 12972 | 56044 | 79675338 |
| Coma scale abnormal | 19.51 | 16.99 | 14 | 12992 | 8664 | 79722718 |
| Toxic skin eruption | 19.47 | 16.99 | 21 | 12985 | 22272 | 79709110 |
| Catatonia | 19.39 | 16.99 | 14 | 12992 | 8742 | 79722640 |
| Salivary hypersecretion | 19.19 | 16.99 | 17 | 12989 | 14207 | 79717175 |
| Dermatitis bullous | 19.17 | 16.99 | 17 | 12989 | 14228 | 79717154 |
| Renal failure | 19.10 | 16.99 | 74 | 12932 | 200894 | 79530488 |
| Lipase increased | 18.94 | 16.99 | 18 | 12988 | 16448 | 79714934 |
| Swelling | 18.74 | 16.99 | 6 | 13000 | 216705 | 79514677 |
| Abnormal behaviour | 18.34 | 16.99 | 26 | 12980 | 36395 | 79694987 |
| Bradycardia | 18.20 | 16.99 | 56 | 12950 | 135501 | 79595881 |
| Agranulocytosis | 18.19 | 16.99 | 29 | 12977 | 45001 | 79686381 |
| Treatment failure | 18.15 | 16.99 | 3 | 13003 | 170483 | 79560899 |
| Disease progression | 18.03 | 16.99 | 4 | 13002 | 184358 | 79547024 |
| Asphyxia | 17.82 | 16.99 | 15 | 12991 | 11705 | 79719677 |
| Klebsiella infection | 17.73 | 16.99 | 17 | 12989 | 15703 | 79715679 |
| Sinusitis | 17.65 | 16.99 | 5 | 13001 | 195496 | 79535886 |
| Dysarthria | 17.64 | 16.99 | 36 | 12970 | 67586 | 79663796 |
| Sudden death | 17.59 | 16.99 | 20 | 12986 | 22491 | 79708891 |
| Hyperthermia | 17.56 | 16.99 | 18 | 12988 | 18019 | 79713363 |
| Tremor | 17.30 | 16.99 | 64 | 12942 | 170019 | 79561363 |
| Abdominal tenderness | 17.02 | 16.99 | 14 | 12992 | 10580 | 79720802 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05BA05 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives |
| FDA CS | M0002356 | Benzodiazepines |
| CHEBI has role | CHEBI:35474 | anti-anxiety agents |
| CHEBI has role | CHEBI:35623 | anticonvulsants |
| CHEBI has role | CHEBI:50266 | Prodrugs |
| CHEBI has role | CHEBI:50268 | GABA modulators |
| MeSH PA | D014151 | Anti-Anxiety Agents |
| MeSH PA | D000927 | Anticonvulsants |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018682 | GABA Agents |
| MeSH PA | D018757 | GABA Modulators |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D014149 | Tranquilizing Agents |
| FDA EPC | N0000175694 | Benzodiazepine |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Anxiety | indication | 48694002 | |
| Alcohol withdrawal syndrome | indication | 191480000 | |
| Partial Epilepsy Treatment Adjunct | indication | ||
| Suicidal thoughts | contraindication | 6471006 | |
| Alcohol intoxication | contraindication | 25702006 | |
| Depressive disorder | contraindication | 35489007 | |
| Substance abuse | contraindication | 66214007 | |
| Psychotic disorder | contraindication | 69322001 | |
| Sleep apnea | contraindication | 73430006 | DOID:0050847 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Hypoalbuminemia | contraindication | 119247004 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Pregnancy, function | contraindication | 289908002 | |
| Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Central nervous system depression | contraindication | 418072004 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.55 | acidic |
| pKa2 | 13.86 | acidic |
| pKa3 | 2.31 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | EC50 | 7.47 | WOMBAT-PK | CHEMBL | |||
| GABA-A receptor alpha-2/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | WOMBAT-PK | CHEMBL | |||||
| GABA-A receptor alpha-3/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | WOMBAT-PK | CHEMBL | |||||
| GABA-A receptor alpha-5/beta-3/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | WOMBAT-PK | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D00694 | KEGG_DRUG |
| 5991-71-9 | SECONDARY_CAS_RN |
| 23887-31-2 | SECONDARY_CAS_RN |
| 2353 | RXNORM |
| 4018712 | VANDF |
| 4019688 | VANDF |
| C0008174 | UMLSCUI |
| CHEBI:59590 | CHEBI |
| CHEMBL1213252 | ChEMBL_ID |
| CHEMBL2106085 | ChEMBL_ID |
| CHEMBL2096631 | ChEMBL_ID |
| DB00628 | DRUGBANK_ID |
| 2809 | PUBCHEM_CID |
| 7548 | IUPHAR_LIGAND_ID |
| 388 | MMSL |
| 4481 | MMSL |
| d00198 | MMSL |
| 001456 | NDDF |
| 001457 | NDDF |
| 001458 | NDDF |
| 371349001 | SNOMEDCT_US |
| 387453004 | SNOMEDCT_US |
| 39815009 | SNOMEDCT_US |
| D003009 | MESH_DESCRIPTOR_UI |
| 2224 | INN_ID |
| MS63G8NQUI | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0030 | TABLET | 3.75 mg | ORAL | ANDA | 19 sections |
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0040 | TABLET | 7.50 mg | ORAL | ANDA | 19 sections |
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0070 | TABLET | 15 mg | ORAL | ANDA | 19 sections |
| CLORAZEPATE DIPOTASSIUM | Human Prescription Drug Label | 1 | 13107-319 | TABLET | 3.75 mg | ORAL | ANDA | 26 sections |
| CLORAZEPATE DIPOTASSIUM | Human Prescription Drug Label | 1 | 13107-319 | TABLET | 3.75 mg | ORAL | ANDA | 26 sections |
| CLORAZEPATE DIPOTASSIUM | Human Prescription Drug Label | 1 | 13107-319 | TABLET | 3.75 mg | ORAL | ANDA | 26 sections |
| CLORAZEPATE DIPOTASSIUM | Human Prescription Drug Label | 1 | 13107-320 | TABLET | 7.50 mg | ORAL | ANDA | 26 sections |
| CLORAZEPATE DIPOTASSIUM | Human Prescription Drug Label | 1 | 13107-320 | TABLET | 7.50 mg | ORAL | ANDA | 26 sections |
| CLORAZEPATE DIPOTASSIUM | Human Prescription Drug Label | 1 | 13107-320 | TABLET | 7.50 mg | ORAL | ANDA | 26 sections |
| CLORAZEPATE DIPOTASSIUM | Human Prescription Drug Label | 1 | 13107-321 | TABLET | 15 mg | ORAL | ANDA | 26 sections |
| CLORAZEPATE DIPOTASSIUM | Human Prescription Drug Label | 1 | 13107-321 | TABLET | 15 mg | ORAL | ANDA | 26 sections |
| CLORAZEPATE DIPOTASSIUM | Human Prescription Drug Label | 1 | 13107-321 | TABLET | 15 mg | ORAL | ANDA | 26 sections |
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-433 | TABLET | 3.75 mg | ORAL | ANDA | 20 sections |
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-434 | TABLET | 7.50 mg | ORAL | ANDA | 20 sections |
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-030 | TABLET | 15 mg | ORAL | ANDA | 19 sections |
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-030 | TABLET | 15 mg | ORAL | ANDA | 19 sections |
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-893 | TABLET | 15 mg | ORAL | ANDA | 24 sections |
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4042 | TABLET | 3.75 mg | ORAL | ANDA | 24 sections |
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4043 | TABLET | 7.50 mg | ORAL | ANDA | 24 sections |
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4044 | TABLET | 15 mg | ORAL | ANDA | 24 sections |
| TranxeneT-Tab | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55292-302 | TABLET | 7.50 mg | ORAL | NDA | 19 sections |
| TranxeneT-Tab | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55292-304 | TABLET | 7.50 mg | ORAL | NDA | 19 sections |
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-4754 | TABLET | 3.75 mg | ORAL | ANDA | 19 sections |
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-4755 | TABLET | 7.50 mg | ORAL | ANDA | 19 sections |
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-4756 | TABLET | 15 mg | ORAL | ANDA | 19 sections |
| Clorazepate dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63304-552 | TABLET | 3.75 mg | ORAL | ANDA | 16 sections |
| Clorazepate dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63304-553 | TABLET | 7.50 mg | ORAL | ANDA | 16 sections |
| Clorazepate dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63304-554 | TABLET | 15 mg | ORAL | ANDA | 16 sections |
| Clorazepate dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67046-904 | TABLET | 7.50 mg | ORAL | ANDA | 16 sections |
| Clorazepate Dipotassium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67046-906 | TABLET | 7.50 mg | ORAL | ANDA | 20 sections |