aceclofenac indications/contra

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibufenac derivatives 43 89796-99-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aceclofenac
  • aceclofar
  • hifenac
  • Molecular weight: 354.18
  • Formula: C16H13Cl2NO4
  • CLOGP: 4.59
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.63
  • ALOGS: -5.25
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.20 g O

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC M01AB16 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
ATC M02AA25 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35481 non-narcotic analgesic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatoid arthritis indication 69896004 DOID:7148
Backache indication 161891005
Osteoarthritis indication 396275006 DOID:381
Adhesive capsulitis of shoulder indication 399114005 DOID:14188

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.37 acidic
pKa2 1.38 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR DRUG LABEL SCIENTIFIC LITERATURE
Mitogen-activated protein kinase 1 Kinase IC50 5.23 DRUG MATRIX
Transthyretin Secreted Kd 5.92 CHEMBL
Aldose reductase Enzyme IC50 5.89 DRUG MATRIX

External reference:

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IDSource
C0050403 UMLSCUI
D01545 KEGG_DRUG
391703003 SNOMEDCT_US
16689 RXNORM
329923004 SNOMEDCT_US
005957 NDDF
CHEMBL93645 ChEMBL_ID
71771 PUBCHEM_CID
C056498 MESH_SUPPLEMENTAL_RECORD_UI
DB06736 DRUGBANK_ID
RPK779R03H UNII
5608 INN_ID
CHEBI:31159 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Clanza HUMAN PRESCRIPTION DRUG LABEL 1 65697-450 TABLET, FILM COATED 200 mg ORAL Export only 15 sections