esflurbiprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory agents, ibuprofen derivatives	5060	51543-39-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

loqoa
esflurbiprofen
TT-063

Molecular weight: 244.27
Formula: C15H13FO2
CLOGP: 3.75
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 37.30
ALOGS: -3.99
ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Sept. 28, 2015	PMDA	Taisho Pharmaceutical Co., Ltd.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M02AA29	MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Osteoarthritis	indication	396275006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.2	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN		IC50	6.04		CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_RAT		IC50	7.52		CHEMBL

External reference:

ID	Source
J5ZZK9P7MX	UNII
D10254	KEGG_DRUG
C2825249	UMLSCUI
CHEBI:42446	CHEBI
CHEMBL435298	ChEMBL_ID
72099	PUBCHEM_CID
DB16159	DRUGBANK_ID
5776	INN_ID
9420	IUPHAR_LIGAND_ID
019240	NDDF
FLP	PDB_CHEM_ID

Pharmaceutical products:

None