bufexamac 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibufenac derivatives 3047 2438-72-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bufexamac
  • bufexamic acid
  • feximac
  • mofenar
  • parfenal
A benzeneacetamide with anti-inflammatory, analgesic, and antipyretic action. It is administered topically, orally, or rectally.
  • Molecular weight: 223.27
  • Formula: C12H17NO3
  • CLOGP: 1.85
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 58.56
  • ALOGS: -2.98
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AB17 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
ATC M02AA09 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35493 anti-pyretic

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.5 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histone deacetylase 6 Enzyme INHIBITOR Kd 4.97 IUPHAR
Histone deacetylase 10 Enzyme INHIBITOR Kd 4.91 IUPHAR
Arachidonate 5-lipoxygenase Enzyme IC50 6.89 CHEMBL
M1-family alanyl aminopeptidase Enzyme IC50 4.09 CHEMBL

External reference:

IDSource
N0000166889 NUI
D01271 KEGG_DRUG
C0006351 UMLSCUI
CHEBI:31317 CHEBI
A4Z PDB_CHEM_ID
CHEMBL94394 ChEMBL_ID
DB13346 DRUGBANK_ID
D002019 MESH_DESCRIPTOR_UI
2466 PUBCHEM_CID
7498 IUPHAR_LIGAND_ID
2557 INN_ID
4T3C38J78L UNII
1796 RXNORM
003713 NDDF
273952005 SNOMEDCT_US
332124001 SNOMEDCT_US

Pharmaceutical products:

None