bufexamac indications/contra

Stem definitionDrug idCAS RN
3047 2438-72-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bufexamac
  • bufexamic acid
  • feximac
  • mofenar
  • parfenal
A benzeneacetamide with anti-inflammatory, analgesic, and antipyretic action. It is administered topically, orally, or rectally.
  • Molecular weight: 223.27
  • Formula: C12H17NO3
  • CLOGP: 1.85
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 58.56
  • ALOGS: -2.98
  • ROTB: 6

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC M01AB17 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
ATC M02AA09 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
CHEBI has role CHEBI:35481 non-narcotic analgesic
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35493 antipyretic
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.5 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histone deacetylase 10 Enzyme INHIBITOR Kd 4.91 IUPHAR
Histone deacetylase 6 Enzyme INHIBITOR Kd 4.97 IUPHAR
Arachidonate 5-lipoxygenase Enzyme IC50 6.89 CHEMBL
M1-family alanyl aminopeptidase Unclassified IC50 4.09 CHEMBL

External reference:

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IDSource
N0000166889 NUI
C0006351 UMLSCUI
7498 IUPHAR_LIGAND_ID
D01271 KEGG_DRUG
4T3C38J78L UNII
2557 INN_ID
2466 PUBCHEM_CID
N0000166889 NDFRT
003713 NDDF
1796 RXNORM
273952005 SNOMEDCT_US
332124001 SNOMEDCT_US
CHEMBL94394 ChEMBL_ID
CHEBI:31317 CHEBI
D002019 MESH_DESCRIPTOR_UI
DB13346 DRUGBANK_ID
A4Z PDB_CHEM_ID

Pharmaceutical products:

None