fentiazac Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibufenac derivatives 1165 18046-21-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fentiazac calcium
  • fentiazac
  • donorest
  • flogene
  • Molecular weight: 329.80
  • Formula: C17H12ClNO2S
  • CLOGP: 4.37
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 50.19
  • ALOGS: -5.38
  • ROTB: 4

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AB10 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
ATC M02AA14 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.57 acidic
pKa2 0.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin D2 receptor 2 GPCR IC50 6.26 CHEMBL

External reference:

IDSource
D01975 KEGG_DRUG
0YHF6E6NLS UNII
3710 INN_ID
005946 NDDF
85721-24-0 SECONDARY_CAS_RN
CHEMBL589092 ChEMBL_ID
CHEBI:94523 CHEBI
28871 PUBCHEM_CID
DB13217 DRUGBANK_ID
C006124 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None