desonide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
steroids for topical use, acetal derivatives	3135	638-94-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: desonide budesonide acetonide prednacinolone	A nonfluorinated corticosteroid anti-inflammatory agent used topically for DERMATOSES. Molecular weight: 416.51 Formula: C24H32O6 CLOGP: 2.37 LIPINSKI: 0 HAC: 6 HDO: 2 TPSA: 93.06 ALOGS: -3.85 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

desonide
budesonide acetonide
prednacinolone

A nonfluorinated corticosteroid anti-inflammatory agent used topically for DERMATOSES.

Molecular weight: 416.51
Formula: C24H32O6
CLOGP: 2.37
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 93.06
ALOGS: -3.85
ROTB: 2

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 4, 1972	FDA	PERRIGO NEW YORK

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	1119.94	25.29	280	4808	24096	63459838
Drug ineffective	244.55	25.29	352	4736	1044413	62439521
Chronic sinusitis	226.88	25.29	70	5018	12773	63471161
Paraesthesia oral	195.21	25.29	69	5019	19187	63464747
Procedural pain	187.57	25.29	69	5019	21500	63462434
Dermatitis atopic	154.93	25.29	49	5039	9675	63474259
Psoriasis	125.21	25.29	81	5007	86876	63397058
Vaginal flatulence	102.94	25.29	28	5060	3265	63480669
Dyspepsia	97.50	25.29	74	5014	102122	63381812
Proctitis	93.24	25.29	29	5059	5412	63478522

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Psoriasis	123.44	23.54	57	2234	38755	34915885
Dermatitis atopic	90.81	23.54	27	2264	5320	34949320
Dry skin	39.69	23.54	25	2266	31262	34923378
Drug ineffective	34.32	23.54	85	2206	456666	34497974
Pruritus	32.37	23.54	43	2248	141938	34812702
Product dose omission issue	31.60	23.54	39	2252	119672	34834968
Skin exfoliation	30.05	23.54	20	2271	27412	34927228
Hepatic lesion	27.43	23.54	10	2281	3702	34950938
Ocular hyperaemia	24.86	23.54	13	2278	11439	34943201

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	236.24	22.01	68	5502	11228	79727590
Chronic sinusitis	226.67	22.01	68	5502	12958	79725860
Paraesthesia oral	196.44	22.01	68	5502	20403	79718415
Procedural pain	188.45	22.01	68	5502	23016	79715802
Psoriasis	151.49	22.01	88	5482	89499	79649319
Dermatitis atopic	147.26	22.01	46	5524	10010	79728808
Vaginal flatulence	108.55	22.01	27	5543	2548	79736270
Dyspepsia	100.21	22.01	73	5497	108614	79630204
Therapeutic product effect incomplete	89.24	22.01	76	5494	141569	79597249
Female genital tract fistula	86.06	22.01	27	5543	5948	79732870

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	D07AB08	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, moderately potent (group II)
ATC	D07BB02	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS Corticosteroids, moderately potent, combinations with antiseptics
ATC	S01BA11	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids, plain
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
FDA EPC	N0000175576	Corticosteroid
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
MeSH PA	D000893	Anti-Inflammatory Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Otitis externa	indication	3135009
Atopic dermatitis	indication	24079001	DOID:3310
Crohn's disease	indication	34000006
Contact dermatitis	indication	40275004	DOID:2773
Seborrheic dermatitis	indication	50563003	DOID:8741
Lichen simplex chronicus	indication	53891004
Allergic rhinitis	indication	61582004
Granuloma annulare	indication	65508009	DOID:3777
Pruritus ani	indication	90446007
Asthma	indication	195967001	DOID:2841

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.78	acidic
pKa2	12.78	acidic

Orange Book patent data (new drug applications)

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Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
0.05%	VERDESO	ALMIRALL	N021978	Sept. 19, 2006	RX	AEROSOL, FOAM	TOPICAL	8962000	Aug. 31, 2025	TREATMENT OF ATOPIC DERMATITIS
0.05%	VERDESO	ALMIRALL	N021978	Sept. 19, 2006	RX	AEROSOL, FOAM	TOPICAL	9492384	Aug. 31, 2025	TREATMENT OF ATOPIC DERMATITIS
0.05%	VERDESO	ALMIRALL	N021978	Sept. 19, 2006	RX	AEROSOL, FOAM	TOPICAL	8460641	Aug. 13, 2027	TREATMENT OF ATOPIC DERMATITIS

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Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST				CHEMBL	CHEMBL

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External reference:

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ID	Source
002199	NDDF
1093	MMSL
2889	INN_ID
3254	RXNORM
4018267	VUID
4018267	VANDF
412363005	SNOMEDCT_US
4550	MMSL
52215008	SNOMEDCT_US
5311066	PUBCHEM_CID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
DESONATE	HUMAN PRESCRIPTION DRUG LABEL	1	10922-828	GEL	0.50 mg	TOPICAL	NDA	24 sections
DESONATE	HUMAN PRESCRIPTION DRUG LABEL	1	50222-504	GEL	0.50 mg	TOPICAL	NDA	24 sections
DESONATE	HUMAN PRESCRIPTION DRUG LABEL	1	50419-828	GEL	0.50 mg	TOPICAL	NDA	24 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	0115-1517	LOTION	0.50 mg	TOPICAL	ANDA	17 sections
desonide	HUMAN PRESCRIPTION DRUG LABEL	1	0168-0309	OINTMENT	0.50 mg	TOPICAL	ANDA	17 sections
desonide	HUMAN PRESCRIPTION DRUG LABEL	1	0168-0310	LOTION	0.50 mg	TOPICAL	ANDA	19 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	0472-0803	LOTION	0.50 mg	TOPICAL	ANDA	19 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	0472-0804	CREAM	0.50 mg	TOPICAL	NDA authorized generic	19 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0661	CREAM	0.50 mg	TOPICAL	ANDA	18 sections
Desonide	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0661	CREAM	0.50 mg	TOPICAL	ANDA	18 sections

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