triamcinolone indications/contra

Stem definitionDrug idCAS RN
steroids not used as glucocorticosteroids 2725 124-94-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triamcinolone
  • triamcinlon
  • triamcinolon
  • rodinolone
A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
  • Molecular weight: 394.44
  • Formula: C21H27FO6
  • CLOGP: 0.71
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 115.06
  • ALOGS: -2.67
  • ROTB: 2

Drug dosage:

DoseUnitRoute
7.50 mg O
7.50 mg P
0.22 mg N

Approvals:

DateAgencyCompanyOrphan
Dec. 3, 1957 FDA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cushing's syndrome 630.29 52.63 96 939 1050 3383774
Drug interaction 335.81 52.63 111 924 46701 3338123
Ocular hypertension 266.96 52.63 39 996 303 3384521
Adrenal insufficiency 237.01 52.63 45 990 1876 3382948
Adrenal suppression 234.42 52.63 34 1001 249 3384575
Visual acuity reduced 226.19 52.63 57 978 8957 3375867
Retinal artery occlusion 164.14 52.63 28 1007 625 3384199
Intraocular pressure increased 161.52 52.63 34 1001 2388 3382436
Retinal pigment epithelial tear 159.55 52.63 25 1010 321 3384503
Retinal detachment 159.37 52.63 33 1002 2138 3382686
Cushingoid 148.33 52.63 26 1009 683 3384141
Spinal cord infarction 138.06 52.63 20 1015 144 3384680
Mycotic endophthalmitis 130.66 52.63 16 1019 21 3384803
Chorioretinal disorder 117.74 52.63 16 1019 67 3384757
Secondary adrenocortical insufficiency 117.22 52.63 18 1017 200 3384624
Glaucoma 114.08 52.63 26 1009 2630 3382194
Cataract 110.91 52.63 31 1004 7145 3377679
Endophthalmitis 99.31 52.63 21 1014 1498 3383326
Human antichimeric antibody positive 98.30 52.63 12 1023 15 3384809
Product use issue 97.93 52.63 34 1001 15967 3368857
Cytomegalovirus chorioretinitis 97.72 52.63 17 1018 425 3384399
Eye infection toxoplasmal 97.71 52.63 14 1021 92 3384732
Drug ineffective 95.00 52.63 61 974 116029 3268795
Chorioretinopathy 94.83 52.63 17 1018 507 3384317
Body height below normal 85.97 52.63 13 1022 129 3384695
Necrotising retinitis 77.97 52.63 12 1023 135 3384689
Retinal haemorrhage 74.74 52.63 18 1017 2302 3382522
Non-infectious endophthalmitis 73.12 52.63 11 1024 105 3384719
Bone density decreased 72.44 52.63 16 1019 1397 3383427
Obesity 70.73 52.63 17 1018 2155 3382669

Pharmacologic Action:

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SourceCodeDescription
ATC A01AC01 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Corticosteroids for local oral treatment
ATC C05AA12 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AB09 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC D07XB02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, moderately potent, other combinations
ATC H02AB08 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD11 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R03BA06 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Glucocorticoids
ATC S01BA05 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC D07BB03 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, moderately potent, combinations with antiseptics
ATC D07CB01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, moderately potent, combinations with antibiotics
ATC S02CA04 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA EPC N0000175576 Corticosteroid
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
MeSH PA D000305 Adrenal Cortex Hormones
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D006730 Hormones, Hormone Substitutes, and Hormone Antagonists
CHEBI has role CHEBI:50857 anti-allergic agent
CHEBI has role CHEBI:35472 anti-inflammatory drug

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001 DOID:4724
Lichen planus indication 4776004 DOID:9201
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:13404
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001 DOID:9008
Keloid scar indication 33659008
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Candidiasis of skin indication 49883006
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Necrobiosis lipoidica diabeticorum indication 56391002
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Alopecia areata indication 68225006 DOID:986
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Sympathetic uveitis indication 75315001 DOID:12029
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Autoimmune disease indication 85828009
Congenital hypoplastic anemia indication 88854002 DOID:1342
Pruritus ani indication 90446007
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Subacute bursitis indication 109298000
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009 DOID:8651
Non-Hodgkin's lymphoma indication 118601006 DOID:8675
Mycosis fungoides indication 118618005 DOID:8691
Uveitis indication 128473001 DOID:13141
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Follicular non-Hodgkin's lymphoma indication 308121000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000 DOID:13774
Adrenal cortical hypofunction indication 386584007 DOID:10493
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Asthma management indication 406162001
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Giant cell arteritis indication 414341000 DOID:13375
Synovitis indication 416209007 DOID:2703
Aphthous ulcer of mouth indication 426965005 DOID:9663
Post traumatic osteoarthritis indication 699262001
Erythroblastic Anemia indication
Chronic Non-Allergic Rhinitis indication
Diagnostic Test for Cushing's Syndrome indication
Vitrectomy Adjunct to Enhance Visualization indication
Gingival Disorders indication
Systemic Dermatomyositis indication
Transfusion Reaction Urticaria indication
Synovitis due to Osteoarthritis indication
Allergic Rhinitis Prevention indication
Cystic Aponeurosis Tumor indication
Severe Ocular Inflammation indication
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Epistaxis contraindication 12441001
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Disease caused by parasite contraindication 17322007
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Glaucoma contraindication 23986001 DOID:1686
Acute tuberculosis contraindication 25629007
Fungal infection of eye contraindication 31194008
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Herpes zoster keratoconjunctivitis contraindication 42448002
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004 DOID:9280
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Candidiasis of mouth contraindication 79740000 DOID:14262
Perforation of nasal septum contraindication 80142000
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Bacterial infectious disease contraindication 87628006 DOID:104
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Operation on nose contraindication 88733004
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002 DOID:1826
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Disease of liver contraindication 235856003 DOID:409
Telangiectasia disorder contraindication 247479008 DOID:1272
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Oral infection contraindication 275393007
Varicella-zoster virus infection contraindication 309465005
Viral eye infection contraindication 312132001
Osteopenia contraindication 312894000
Skin irritation contraindication 367466007
Herpes zoster keratitis contraindication 397573005
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006 DOID:2733
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Nasal Septal Ulcers contraindication
Untreated Fungal Infection contraindication
Nasal Candidiasis contraindication
Uncontrolled Bacterial Infections contraindication
Arginosuccinate Lyase Deficiency contraindication
Oropharyngeal Candidiasis contraindication
Periodontal Infections contraindication
Ornithine Carbamyltransferase Deficiency contraindication
Nasal Trauma contraindication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
West syndrome off-label use 28055006 DOID:2481
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Eczema off-label use 43116000 DOID:2723
Respiratory distress syndrome in the newborn off-label use 46775006 DOID:12716
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007 DOID:1156
Polymyalgia rheumatica off-label use 65323003 DOID:853
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006 DOID:8506
Hepatic necrosis off-label use 87248009
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Severe chronic obstructive pulmonary disease off-label use 313299006
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Neonatal Bronchopulmonary Dysplasia off-label use
Hypercalcemia associated with Sarcoidosis off-label use

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.2 acidic
pKa2 11.84 acidic
pKa3 13.18 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Ki 7.59 DRUG MATRIX CHEMBL
Progesterone receptor Nuclear hormone receptor WOMBAT-PK
Annexin A1 Cytosolic other WOMBAT-PK

External reference:

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IDSource
2870 IUPHAR_LIGAND_ID
4017599 VUID
N0000145980 NUI
C0040864 UMLSCUI
D00385 KEGG_DRUG
1ZK20VI6TY UNII
755 INN_ID
DB00620 DRUGBANK_ID
4017599 VANDF
N0000005981 NDFRT
N0000145980 NDFRT
4582 MMSL
10759 RXNORM
116594009 SNOMEDCT_US
5613 MMSL
d00620 MMSL
002188 NDDF
6028009 SNOMEDCT_US
CHEMBL1451 ChEMBL_ID
31307 PUBCHEM_CID
D014221 MESH_DESCRIPTOR_UI
CHEBI:9667 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
TRIAMCINOLONE ACETONIDE HUMAN PRESCRIPTION DRUG LABEL 1 67877-470 CREAM 0.25 mg TOPICAL ANDA 10 sections
TRIAMCINOLONE ACETONIDE HUMAN PRESCRIPTION DRUG LABEL 1 67877-471 CREAM 1 mg TOPICAL ANDA 10 sections
TRIAMCINOLONE ACETONIDE HUMAN PRESCRIPTION DRUG LABEL 1 67877-472 CREAM 5 mg TOPICAL ANDA 10 sections