clobetasone butyrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3911 25122-57-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • eumovate
  • kindavate
  • clobetasone butyrate
  • 21-Chloro-11-dehydrobetamethasone
  • clobetasone 17-butyrate
  • Molecular weight: 478.99
  • Formula: C26H32ClFO5
  • CLOGP: 4.21
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 77.51
  • ALOGS: -5.44
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Steroid withdrawal syndrome 96.54 39.62 16 1637 529 63486840
Skin weeping 78.07 39.62 14 1639 739 63486630
Skin exfoliation 76.63 39.62 32 1621 43070 63444299
Skin burning sensation 46.43 39.62 16 1637 12718 63474651
Pruritus 45.13 39.62 51 1602 361402 63125967
Eczema 41.18 39.62 19 1634 32272 63455097

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Skin weeping 85.19 37.50 16 2180 1031 79741161
Steroid withdrawal syndrome 84.48 37.50 15 2181 706 79741486
Skin exfoliation 79.79 37.50 36 2160 55064 79687128
Rash 57.95 37.50 75 2121 578283 79163909
Skin burning sensation 56.51 37.50 19 2177 13253 79728939
Eczema 47.66 37.50 23 2173 40795 79701397
Burns second degree 44.36 37.50 11 2185 2617 79739575
Steroid dependence 44.35 37.50 11 2185 2619 79739573
Medication error 44.18 37.50 26 2170 68616 79673576
Pruritus 42.25 37.50 53 2143 394595 79347597
Catarrh 41.25 37.50 10 2186 2168 79740024

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AB01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC S01BA09 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01CA11 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Eczema indication 43116000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST KEGG DRUG KEGG DRUG

External reference:

IDSource
D01273 KEGG_DRUG
C0055896 UMLSCUI
CHEBI:31415 CHEBI
CHEMBL2308885 ChEMBL_ID
C010893 MESH_SUPPLEMENTAL_RECORD_UI
8U0H6XI6EO UNII
71386 PUBCHEM_CID
DB13158 DRUGBANK_ID
108074 RXNORM
003809 NDDF
003810 NDDF
116576003 SNOMEDCT_US
395963000 SNOMEDCT_US
395967004 SNOMEDCT_US
C0360518 UMLSCUI
3155 INN_ID
54063-32-0 SECONDARY_CAS_RN
71387 PUBCHEM_CID
9088 IUPHAR_LIGAND_ID
LT69WY1J6D UNII

Pharmaceutical products:

None