niflumic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anti-inflammatory, anilinonicotinic acid derivatives | 1925 | 4394-00-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.75 | g | O |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Aspirin-exacerbated respiratory disease | 69.17 | 53.47 | 9 | 96 | 1198 | 79743085 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | M01AX02 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Other antiinflammatory and antirheumatic agents, non-steroids |
| ATC | M02AA17 | MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D016861 | Cyclooxygenase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.74 | acidic |
| pKa2 | 5.54 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | IC50 | 6.04 | DRUG MATRIX | |||||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 5.97 | DRUG MATRIX | |||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Enzyme | IC50 | 4.77 | CHEMBL | |||||
| Transthyretin | Secreted | Kd | 6.59 | CHEMBL | |||||
| Chloride channel protein ClC-Ka | Ion channel | ACTIVATOR | EC50 | 5 | IUPHAR | ||||
| Potassium channel subfamily T member 2 | Ion channel | ACTIVATOR | EC50 | 8.68 | IUPHAR | ||||
| G-protein coupled receptor 35 | GPCR | Ki | 5.44 | CHEMBL | |||||
| Chloride channel protein ClC-Kb | Ion channel | ACTIVATOR | EC50 | 5 | IUPHAR | ||||
| Transcriptional enhancer factor TEF-3 | Transcription factor | Kd | 4.55 | CHEMBL | |||||
| Transcription factor SOX-18 | Unclassified | IC50 | 4.30 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167326 | NUI |
| D08275 | KEGG_DRUG |
| C0028067 | UMLSCUI |
| CHEBI:34888 | CHEBI |
| NFL | PDB_CHEM_ID |
| CHEMBL63323 | ChEMBL_ID |
| DB04552 | DRUGBANK_ID |
| D009544 | MESH_DESCRIPTOR_UI |
| 4488 | PUBCHEM_CID |
| 2439 | IUPHAR_LIGAND_ID |
| 2194 | INN_ID |
| 4U5MP5IUD8 | UNII |
| 7418 | RXNORM |
| 005830 | NDDF |
Pharmaceutical products:
None