ambroxol indications/contra

Stem definitionDrug idCAS RN
mucolytic, bromhexine derivatives 147 18683-91-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ambroxol hydrochloride
  • ambroxol
  • ambroxils
  • lasolvan
  • ambroxol HCl
A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.
  • Molecular weight: 378.11
  • Formula: C13H18Br2N2O
  • CLOGP: 2.33
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 58.28
  • ALOGS: -4.31
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.12 g O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1978 YEAR INTRODUCED

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Stevens-Johnson syndrome 83.99 61.42 16 96 6756 3378991

Pharmacologic Action:

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SourceCodeDescription
ATC R05CB06 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS
Mucolytics
MeSH PA D005100 Expectorants
MeSH PA D019141 Respiratory System Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Sore throat symptom indication 267102003

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.75 Basic
pKa2 0.27 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter Ki 5.74 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6.25 DRUG MATRIX
Sodium channel protein type 10 subunit alpha Ion channel WOMBAT-PK
Glucosylceramidase Enzyme IC50 5.39 CHEMBL

External reference:

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IDSource
C1367795 UMLSCUI
D01479 KEGG_DRUG
200168S0CL UNII
3692 INN_ID
625 RXNORM
N0000166542 NDFRT
004176 NDDF
698024002 SNOMEDCT_US
703353005 SNOMEDCT_US
CHEMBL153479 ChEMBL_ID
2132 PUBCHEM_CID
23828-92-4 SECONDARY_CAS_RN
DB06742 DRUGBANK_ID
D000551 MESH_DESCRIPTOR_UI
CHEBI:135590 CHEBI

Pharmaceutical products:

None