isoetarine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| bronchodilators, phenethylamine derivatives | 1491 | 530-08-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Adrenergic beta-2 agonist used as bronchodilator for emphysema, bronchitis and asthma.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 40 | mg | O |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 23, 1979 | FDA | ROXANE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R03AC07 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Selective beta-2-adrenoreceptor agonists |
| ATC | R03CC06 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS FOR SYSTEMIC USE Selective beta-2-adrenoreceptor agonists |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D000322 | Adrenergic Agonists |
| MeSH PA | D058666 | Adrenergic beta-2 Receptor Agonists |
| MeSH PA | D000318 | Adrenergic beta-Agonists |
| MeSH PA | D018927 | Anti-Asthmatic Agents |
| MeSH PA | D001993 | Bronchodilator Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D019141 | Respiratory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.76 | acidic |
| pKa2 | 13.15 | acidic |
| pKa3 | 13.89 | acidic |
| pKa4 | 9.14 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Beta-2 adrenergic receptor | GPCR | AGONIST | Kd | 6 | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019792 | VUID |
| N0000147881 | NUI |
| D02093 | KEGG_DRUG |
| 79490-84-9 | SECONDARY_CAS_RN |
| 7279-75-6 | SECONDARY_CAS_RN |
| 4018239 | VANDF |
| 4018240 | VANDF |
| 4019792 | VANDF |
| C0022176 | UMLSCUI |
| CHEBI:6005 | CHEBI |
| CHEMBL1201213 | ChEMBL_ID |
| CHEMBL1201153 | ChEMBL_ID |
| 7205 | IUPHAR_LIGAND_ID |
| 2576-92-3 | SECONDARY_CAS_RN |
| 3762 | PUBCHEM_CID |
| DB00221 | DRUGBANK_ID |
| 102397 | RXNORM |
| 2951 | MMSL |
| 4924 | MMSL |
| 4925 | MMSL |
| 7493 | MMSL |
| d00751 | MMSL |
| 001783 | NDDF |
| 001784 | NDDF |
| 001785 | NDDF |
| 386181008 | SNOMEDCT_US |
| 387369005 | SNOMEDCT_US |
| 66004009 | SNOMEDCT_US |
| 81860007 | SNOMEDCT_US |
| D007528 | MESH_DESCRIPTOR_UI |
| CHEMBL1200920 | ChEMBL_ID |
| 1384 | INN_ID |
| YV0SN3276Q | UNII |
Pharmaceutical products:
None