bambuterol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
bronchodilators, phenethylamine derivatives	285	81732-65-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

bambuterol
bambudil
terbutaline bisdimethylcarbamate
(+/-)-Bambuterol
bambuterol hydrochloride
bambuterol HCl

selective inhibitor of butyrylcholinesterase & acetylcholinesterase

Molecular weight: 367.45
Formula: C18H29N3O5
CLOGP: 0.74
LIPINSKI: 0
HAC: 8
HDO: 2
TPSA: 91.34
ALOGS: -2.89
ROTB: 8

Drug dosage:

Dose	Unit	Route
20	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	33 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.71 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	15 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	1.60 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	18 mL/min/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	2.60 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Jan. 1, 1990	YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Acute kidney injury	71.68	58.01	36	274	519368	79224710

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R03CC12	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS FOR SYSTEMIC USE Selective beta-2-adrenoreceptor agonists
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D019141	Respiratory System Agents
CHEBI has role	CHEBI:35522	beta-adrenergic agonists
CHEBI has role	CHEBI:35523	bronchodilator
CHEBI has role	CHEBI:35524	sympathomimetic
CHEBI has role	CHEBI:38462	acetylcholinesterase inhibitors
CHEBI has role	CHEBI:49167	anti-asthmatic drugs
CHEBI has role	CHEBI:50266	Prodrugs
CHEBI has role	CHEBI:66993	tocolytic drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.12	acidic
pKa2	8.92	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN					WOMBAT-PK
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	5.70		DRUG MATRIX
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		Ki	3.25		WOMBAT-PK
Cholinesterase	Enzyme	P06276	CHLE_HUMAN	INHIBITOR	IC50	8.50		IUPHAR
Butyrylcholinesterase; Protein Bche	Enzyme		Q9JKC1_RAT		IC50	8.52		CHEMBL
Acetylcholinesterase	Enzyme		ACES_RAT		IC50	4.52		CHEMBL
Cholinesterase	Enzyme		CHLE_HORSE		IC50	6.92		CHEMBL

External reference:

ID	Source
D07377	KEGG_DRUG
18751	RXNORM
C0052944	UMLSCUI
CHEBI:553827	CHEBI
CHEMBL521589	ChEMBL_ID
DB01408	DRUGBANK_ID
C047766	MESH_SUPPLEMENTAL_RECORD_UI
54766	PUBCHEM_CID
6601	IUPHAR_LIGAND_ID
5304	INN_ID
81732-46-9	SECONDARY_CAS_RN
Y1850G1OVC	UNII
349923005	SNOMEDCT_US
391812009	SNOMEDCT_US
396462008	SNOMEDCT_US
004156	NDDF
004157	NDDF

Pharmaceutical products:

None