dyclonine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
local anaesthetics	974	586-60-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dyclonine dyclonine hydrochloride dyclocaine dyclonin dyclonine HCl	minor descriptor (66-83); on-line & Index Medicus search PROPIOPHENONES (66-83); RN given refers to parent cpd; structure Molecular weight: 289.42 Formula: C18H27NO2 CLOGP: 4.83 LIPINSKI: 0 HAC: 3 HDO: 0 TPSA: 29.54 ALOGS: -3.80 ROTB: 8 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dyclonine
dyclonine hydrochloride
dyclocaine
dyclonin
dyclonine HCl

minor descriptor (66-83); on-line & Index Medicus search PROPIOPHENONES (66-83); RN given refers to parent cpd; structure

Molecular weight: 289.42
Formula: C18H27NO2
CLOGP: 4.83
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 29.54
ALOGS: -3.80
ROTB: 8

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heart rate abnormal	136.77	23.88	34	2876	4913	63481199
Blood magnesium decreased	107.84	23.88	35	2875	13163	63472949
Productive cough	104.38	23.88	53	2857	63155	63422957
Lymphadenitis	92.97	23.88	23	2887	3252	63482860
Muscle twitching	90.51	23.88	34	2876	19634	63466478
Broncholithiasis	85.39	23.88	14	2896	239	63485873
Infection	83.66	23.88	75	2835	229098	63257014
Lymph node calcification	81.59	23.88	14	2896	318	63485794
Soft tissue disorder	81.40	23.88	22	2888	4400	63481712
Clostridium difficile infection	76.71	23.88	34	2876	29888	63456224

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Choroiditis	83.72	32.26	16	898	1199	34954818
Endophthalmitis	77.30	32.26	18	896	3490	34952527
Completed suicide	64.95	32.26	37	877	98131	34857886
Visual acuity reduced	57.79	32.26	20	894	16129	34939888
Condition aggravated	57.34	32.26	44	870	192152	34763865
Intraocular pressure increased	55.30	32.26	15	899	5368	34950649
Eye pain	49.42	32.26	17	897	13445	34942572
Toxicity to various agents	37.21	32.26	35	879	200327	34755690

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heart rate abnormal	129.78	23.99	34	3634	6023	79734697
Muscle twitching	100.14	23.99	39	3629	24725	79715995
Blood magnesium decreased	99.99	23.99	35	3633	16477	79724243
Productive cough	87.52	23.99	53	3615	88278	79652442
Lymphadenitis	84.85	23.99	23	3645	4632	79736088
Completed suicide	82.63	23.99	77	3591	245690	79495030
Broncholithiasis	78.85	23.99	13	3655	229	79740491
Clostridium difficile infection	76.73	23.99	38	3630	42647	79698073
Lymph node calcification	71.85	23.99	13	3655	402	79740318
Choroiditis	67.06	23.99	15	3653	1366	79739354

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	N01BX02	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, LOCAL Other local anesthetics
ATC	R02AD04	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Anesthetics, local
CHEBI has role	CHEBI:48425	topical anesthetic
MeSH PA	D000777	Anesthetics
MeSH PA	D000779	Anesthetics, Local
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID
Skin irritation	indication	367466007
Local anesthesia	indication	386761002
Itching of skin	indication	418363000
Suppression of the Gag Reflex	indication
Prevent Minor Bacterial Skin Infection	indication
Minor Skin Wound Pain	indication
Mouth Irritation	indication
Conduction disorder of the heart	contraindication	44808001
Bleeding hemorrhoids	contraindication	51551000
Decreased respiratory function	contraindication	80954004

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.79	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium channel protein type 10 subunit alpha	Ion channel	Q9Y5Y9	SCNAA_HUMAN	BLOCKER				DRUGBANK	CHEMBL
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		IC50	6.74		CHEMBL

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External reference:

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ID	Source
N8R	PDB_CHEM_ID
001336	NDDF
005055	NDDF
078A24Q30O	UNII
23564005	SNOMEDCT_US
23744	RXNORM
3180	PUBCHEM_CID
370307004	SNOMEDCT_US
4018913	VANDF
4019739	VUID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ambix First Aid	HUMAN OTC DRUG LABEL	2	10038-250	CREAM	0.01 g	TOPICAL	OTC monograph not final	11 sections
Benzethonium chloride and Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	0363-0210	LIQUID	0.23 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride and Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	0363-0210	LIQUID	0.23 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium Chloride and Dyclonine Hydrochloride	HUMAN OTC DRUG LABEL	2	11822-0779	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	11673-629	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	11673-629	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	11822-0128	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	11822-0128	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	30142-150	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections
Benzethonium chloride Plus Dyclonine hydrochloride	HUMAN OTC DRUG LABEL	2	30142-150	LIQUID	0.75 mg	TOPICAL	OTC monograph not final	15 sections

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