aminobutyric acid Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
1262 56-12-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • GABA
  • 4-aminobutanoic acid
  • piperidic acid
  • 4-aminobutyric acid
  • gaballon
  • aminalon
  • aminobutyric acid
  • .GAMMA.-AMINOBUTYRIC ACID
  • gamma-Aminobutyric Acid
The most common inhibitory neurotransmitter in the central nervous system.
  • Molecular weight: 103.12
  • Formula: C4H9NO2
  • CLOGP: -2.77
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 63.32
  • ALOGS: 0.55
  • ROTB: 3

Drug dosage:

DoseUnitRoute
1 g O
1 g P

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 21.42 0 4 3 42441 4596544

Pharmacologic Action:

SourceCodeDescription
ATC N03AG03 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
MeSH PA D018682 GABA Agents
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.87 acidic
pKa2 10.45 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Gamma-aminobutyric acid receptor subunit rho-1 Ion channel EC50 6.57 CHEMBL
Sodium- and chloride-dependent GABA transporter 1 Transporter IC50 5.30 CHEMBL
Sodium- and chloride-dependent GABA transporter 3 Transporter IC50 5.15 CHEMBL
Sodium- and chloride-dependent betaine transporter Transporter IC50 4.44 CHEMBL
Gamma-aminobutyric acid receptor subunit gamma-1 Ion channel IC50 7.48 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-2 Ion channel IC50 7.66 CHEMBL
Sodium- and chloride-dependent GABA transporter 1 Transporter IC50 5.59 CHEMBL
Sodium- and chloride-dependent GABA transporter 2 Unclassified IC50 5.30 CHEMBL
Sodium- and chloride-dependent GABA transporter 1 Transporter IC50 5.14 CHEMBL
Sodium- and chloride-dependent GABA transporter 2 Unclassified IC50 4.56 CHEMBL
Sodium- and chloride-dependent GABA transporter 3 Unclassified IC50 5.09 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-1 Ion channel EC50 5 CHEMBL

External reference:

IDSource
D000613 MESH_DESCRIPTOR_UI
D005680 MESH_DESCRIPTOR_UI
4034308 VUID
N0000191506 NUI
C0016904 UMLSCUI
2ACZ6IPC6I UNII
70582 RXNORM
CHEBI:16865 CHEBI
CHEMBL96 ChEMBL_ID
DB02530 DRUGBANK_ID
119 PUBCHEM_CID
1067 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Gongjinhyang Qi and Jin Eye HUMAN OTC DRUG LABEL 1 53208-500 CREAM 0.02 mL TOPICAL unapproved drug other 10 sections
Theraproxen-90 HUMAN PRESCRIPTION DRUG LABEL 2 68405-018 KIT 100 mg None unapproved drug other 24 sections
Prazolamine HUMAN PRESCRIPTION DRUG LABEL 2 68405-028 KIT 100 mg None unapproved drug other 26 sections
Theratramadol-90 HUMAN PRESCRIPTION DRUG LABEL 2 68405-038 KIT 100 mg None unapproved drug other 21 sections
Therabenzaprine-90 HUMAN PRESCRIPTION DRUG LABEL 2 68405-058 KIT 100 mg None unapproved drug other 22 sections
Therapentin-90 HUMAN PRESCRIPTION DRUG LABEL 2 68405-068 KIT 100 mg None unapproved drug other 22 sections
Therafeldamine HUMAN PRESCRIPTION DRUG LABEL 2 68405-078 KIT 100 mg None unapproved drug other 26 sections
Theraprofen-90 HUMAN PRESCRIPTION DRUG LABEL 2 68405-088 KIT 100 mg None unapproved drug other 22 sections
Theracodophen-325 HUMAN PRESCRIPTION DRUG LABEL 3 68405-098 KIT 100 mg None unapproved drug other 25 sections
Theraproxen-500 HUMAN PRESCRIPTION DRUG LABEL 2 68405-118 KIT 100 mg None unapproved drug other 24 sections
Therabenzaprine-90-5 HUMAN PRESCRIPTION DRUG LABEL 2 68405-158 KIT 100 mg None unapproved drug other 21 sections
Theraproxen HUMAN PRESCRIPTION DRUG LABEL 2 68405-180 KIT 100 mg None unapproved drug other 27 sections
Theraprofen-800 HUMAN PRESCRIPTION DRUG LABEL 2 68405-188 KIT 100 mg None unapproved drug other 23 sections
Theracodophen-650 HUMAN PRESCRIPTION DRUG LABEL 3 68405-198 KIT 100 mg None unapproved drug other 24 sections
Theracodophen-Low-90 HUMAN PRESCRIPTION DRUG LABEL 3 68405-298 KIT 100 mg None unapproved drug other 15 sections
Theratramadol-60 HUMAN PRESCRIPTION DRUG LABEL 2 68405-380 KIT 100 mg None unapproved drug other 24 sections
Theracodeine-300 HUMAN PRESCRIPTION DRUG LABEL 3 68405-398 KIT 100 mg ORAL unapproved drug other 23 sections
Theracodophen-750 HUMAN PRESCRIPTION DRUG LABEL 3 68405-498 KIT 100 mg None unapproved drug other 26 sections
Therabenzaprine-60 HUMAN PRESCRIPTION DRUG LABEL 2 68405-580 KIT 100 mg None unapproved drug other 22 sections
Therapentin-60 HUMAN PRESCRIPTION DRUG LABEL 2 68405-680 KIT 100 mg None unapproved drug other 23 sections
Theraprofen-60 HUMAN PRESCRIPTION DRUG LABEL 2 68405-880 KIT 100 mg None unapproved drug other 23 sections