valproic acid Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
2803 99-66-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • divalproex disodium
  • valproic acid
  • 2-Propylpentanoic acid
  • dipropylacetic acid
  • divalproex sodium
  • depakote
  • epival
  • valdisoval
  • valproate semisodium
  • valproate sodium
  • sodium valproate
  • divalproex
  • propylisopropylacetic acid
  • magnesium valproate
  • valproate calcium
A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
  • Molecular weight: 144.21
  • Formula: C8H16O2
  • CLOGP: 2.76
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -1.79
  • ROTB: 5

Drug dosage:

DoseUnitRoute
1.50 g O
1.50 g P
1.50 g R

Approvals:

DateAgencyCompanyOrphan
Feb. 28, 1978 FDA ABBVIE

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 3573.02 34.02 1402 16393 70638 4550559
Seizure 3453.12 34.02 1243 16552 48994 4572203
Hyperammonaemia 3004.18 34.02 584 17211 1545 4619652
Drug interaction 2541.30 34.02 1067 16728 63441 4557756
Foetal exposure during pregnancy 2290.85 34.02 755 17040 22414 4598783
Completed suicide 2230.35 34.02 865 16930 41580 4579617
Foetal anticonvulsant syndrome 2062.18 34.02 334 17461 97 4621100
Hyperammonaemic encephalopathy 1800.53 34.02 325 17470 466 4620731
Drug ineffective 1689.60 34.02 1156 16639 184905 4436292
Somnolence 1675.87 34.02 711 17084 42949 4578248
Ammonia increased 1608.80 34.02 336 17459 1402 4619795
Overdose 1574.54 34.02 680 17115 42879 4578318
Coma 1211.48 34.02 438 17357 17081 4604116
Tremor 1140.27 34.02 514 17281 35745 4585452
Status epilepticus 1070.87 34.02 296 17499 4667 4616530
Encephalopathy 1062.68 34.02 345 17450 9642 4611555
Dysmorphism 1048.09 34.02 215 17580 801 4620396
Thrombocytopenia 1035.52 34.02 524 17271 47149 4574048
Confusional state 1020.68 34.02 523 17272 48311 4572886
Epilepsy 940.66 34.02 311 17484 9207 4611990
Aggression 928.55 34.02 339 17456 13560 4607637
Neuroleptic malignant syndrome 899.79 34.02 267 17528 5480 4615717
Generalised tonic-clonic seizure 886.78 34.02 302 17493 9808 4611389
Cognitive disorder 822.01 34.02 288 17507 10193 4611004
Parkinsonism 800.53 34.02 215 17580 3018 4618179
Drug level decreased 766.40 34.02 195 17600 2184 4619013
Drug level increased 766.35 34.02 241 17554 6045 4615152
Neutropenia 755.50 34.02 426 17369 47524 4573673
Abnormal behaviour 738.47 34.02 276 17519 11780 4609417
Exposure during pregnancy 728.17 34.02 367 17428 32604 4588593
Depressed level of consciousness 725.53 34.02 290 17505 14864 4606333
Intentional overdose 719.45 34.02 320 17475 21446 4599751
Condition aggravated 704.55 34.02 436 17359 57735 4563462
Drug reaction with eosinophilia and systemic symptoms 687.74 34.02 260 17535 11453 4609744
Agitation 686.96 34.02 320 17475 23880 4597317
Suicide attempt 681.04 34.02 304 17491 20538 4600659
Ataxia 671.43 34.02 210 17585 5167 4616030
Developmental delay 652.94 34.02 148 17647 963 4620234
Sedation 650.97 34.02 224 17571 7493 4613704
Gait disturbance 643.81 34.02 350 17445 36290 4584907
Speech disorder developmental 635.69 34.02 125 17670 352 4620845
Pyrexia 614.24 34.02 509 17286 106635 4514562
Mania 604.25 34.02 191 17604 4867 4616330
Extrapyramidal disorder 538.31 34.02 177 17618 5129 4616068
Weight increased 524.61 34.02 306 17489 36275 4584922
Congenital nose malformation 503.48 34.02 92 17703 146 4621051
Pancreatitis 502.21 34.02 232 17563 16946 4604251
Autism spectrum disorder 501.97 34.02 111 17684 634 4620563
Product substitution issue 483.00 34.02 189 17606 9129 4612068
Blood creatine phosphokinase increased 469.85 34.02 213 17582 14886 4606311
Psychotic disorder 469.65 34.02 193 17602 10602 4610595
Disorientation 469.23 34.02 201 17594 12258 4608939
Hypotension 466.11 34.02 358 17437 67042 4554155
Delirium 461.46 34.02 200 17595 12552 4608645
Fall 459.37 34.02 377 17418 77669 4543528
Metabolic acidosis 446.52 34.02 194 17601 12246 4608951
Vomiting 446.25 34.02 447 17348 119252 4501945
Fanconi syndrome 433.25 34.02 96 17699 554 4620643
Dysarthria 431.83 34.02 189 17606 12143 4609054
Hyponatraemia 427.68 34.02 234 17561 24496 4596701
Mental status changes 424.69 34.02 187 17608 12189 4609008
Stevens-Johnson syndrome 415.41 34.02 166 17629 8473 4612724
Treatment noncompliance 403.89 34.02 179 17616 11848 4609349
Lethargy 400.83 34.02 199 17596 17042 4604155
Leukopenia 393.38 34.02 212 17583 21524 4599673
Petit mal epilepsy 392.42 34.02 103 17692 1312 4619885
Hypospadias 375.30 34.02 90 17705 770 4620427
Hypernatraemia 371.14 34.02 107 17688 1968 4619229
Hepatic failure 369.90 34.02 173 17622 12976 4608221
Speech disorder 368.77 34.02 166 17629 11396 4609801
Atrial septal defect 364.32 34.02 119 17676 3370 4617827
Dyskinesia 360.26 34.02 153 17642 9122 4612075
Altered state of consciousness 355.09 34.02 145 17650 7826 4613371
Brain oedema 348.97 34.02 125 17670 4702 4616495
Muscle rigidity 348.74 34.02 119 17676 3868 4617329
Attention deficit/hyperactivity disorder 345.28 34.02 87 17708 931 4620266
Tachycardia 339.90 34.02 219 17576 30926 4590271
Hypothermia 339.02 34.02 119 17676 4215 4616982
Cardio-respiratory arrest 338.27 34.02 186 17609 19636 4601561
Myoclonus 335.64 34.02 124 17671 5100 4616097
Rhabdomyolysis 332.31 34.02 183 17612 19375 4601822
Drug hypersensitivity 329.82 34.02 295 17500 68105 4553092
Electrocardiogram QT prolonged 327.45 34.02 167 17628 15128 4606069
Alanine aminotransferase increased 325.71 34.02 206 17589 28167 4593030
Electroencephalogram abnormal 325.50 34.02 91 17704 1490 4619707
Irritability 325.41 34.02 159 17636 13140 4608057
Drug resistance 325.25 34.02 137 17658 7999 4613198
Disturbance in attention 325.01 34.02 148 17647 10433 4610764
Skull malformation 324.38 34.02 67 17728 259 4620938
Loss of consciousness 322.20 34.02 223 17572 35459 4585738
Unresponsive to stimuli 322.13 34.02 145 17650 9948 4611249
Anticonvulsant drug level increased 320.82 34.02 78 17717 711 4620486
Maternal drugs affecting foetus 318.31 34.02 111 17684 3854 4617343
Product residue present 315.24 34.02 97 17698 2250 4618947
Aspartate aminotransferase increased 313.88 34.02 192 17603 24746 4596451
Hypotonia 307.88 34.02 106 17689 3540 4617657
Lip disorder 305.26 34.02 66 17729 333 4620864
Suicidal ideation 297.01 34.02 176 17619 21407 4599790
Depression 295.91 34.02 238 17557 47495 4573702
Coordination abnormal 287.59 34.02 101 17694 3581 4617616
Catatonia 286.64 34.02 86 17709 1826 4619371
Multiple-drug resistance 281.65 34.02 68 17727 600 4620597
Pancreatitis acute 281.63 34.02 126 17669 8517 4612680
Drug level below therapeutic 281.30 34.02 77 17718 1161 4620036
Poisoning 277.45 34.02 112 17683 5862 4615335
Platelet count decreased 277.26 34.02 202 17593 34800 4586397
Toxic epidermal necrolysis 276.98 34.02 113 17682 6079 4615118
Hepatotoxicity 273.65 34.02 122 17673 8177 4613020
Abortion spontaneous 272.31 34.02 144 17651 14048 4607149
White blood cell count decreased 271.41 34.02 195 17600 32870 4588327
Asterixis 271.32 34.02 64 17731 506 4620691
Schizophrenia 269.49 34.02 97 17698 3698 4617499
Eosinophilia 267.02 34.02 114 17681 6879 4614318
Pneumonia 265.49 34.02 317 17478 102498 4518699
Acute hepatic failure 262.42 34.02 106 17689 5556 4615641
Spina bifida 258.68 34.02 60 17735 437 4620760
Cardiac arrest 257.46 34.02 191 17604 33816 4587381
Anxiety 257.17 34.02 220 17575 47791 4573406
Craniosynostosis 255.01 34.02 54 17741 242 4620955
Dystonia 248.93 34.02 97 17698 4621 4616576
Rash 248.86 34.02 315 17480 108073 4513124
Alopecia 242.85 34.02 171 17624 27909 4593288
Low set ears 242.49 34.02 49 17746 165 4621032
Memory impairment 241.21 34.02 151 17644 20252 4600945
Pneumonia aspiration 240.24 34.02 117 17678 9589 4611608
Hallucination 235.01 34.02 141 17654 17527 4603670
Off label use 233.49 34.02 334 17461 128779 4492418
Toxic encephalopathy 228.45 34.02 71 17724 1703 4619494
Hypertelorism of orbit 224.87 34.02 47 17748 195 4621002
Congenital anomaly 220.91 34.02 73 17722 2143 4619054
Hepatic enzyme increased 219.85 34.02 136 17659 17855 4603342
Insomnia 215.14 34.02 194 17601 45151 4576046
Respiratory arrest 212.63 34.02 120 17675 13300 4607897
Sudden unexplained death in epilepsy 212.25 34.02 46 17749 235 4620962
Fatigue 209.98 34.02 339 17456 145227 4475970
Bipolar disorder 208.63 34.02 70 17725 2156 4619041
Mental impairment 205.85 34.02 85 17710 4713 4616484
Salivary hypersecretion 204.51 34.02 74 17721 2863 4618334
Balance disorder 204.00 34.02 125 17670 16131 4605066
Intentional self-injury 203.99 34.02 96 17699 7287 4613910
Sleep disorder 203.97 34.02 110 17685 11153 4610044
Hepatitis 203.89 34.02 113 17682 12092 4609105
Pancytopenia 202.54 34.02 146 17649 24707 4596490
Liver function test abnormal 202.53 34.02 120 17675 14572 4606625
Ventricular septal defect 200.29 34.02 69 17726 2306 4618891
Cerebral atrophy 199.66 34.02 63 17732 1590 4619607
Partial seizures 199.44 34.02 64 17731 1708 4619489
Anticonvulsant drug level decreased 197.97 34.02 50 17745 540 4620657
White blood cell count increased 195.69 34.02 119 17676 15148 4606049
Stupor 195.09 34.02 60 17735 1388 4619809
Multiple organ dysfunction syndrome 194.89 34.02 128 17667 18628 4602569
Drug abuse 193.79 34.02 149 17646 27798 4593399
Blood lactic acid increased 193.68 34.02 64 17731 1878 4619319
Drug-induced liver injury 193.10 34.02 97 17698 8494 4612703
Limb malformation 193.01 34.02 45 17750 336 4620861
Myocarditis 192.88 34.02 74 17721 3377 4617820
Meningomyelocele 190.58 34.02 42 17753 235 4620962
Transaminases increased 188.55 34.02 99 17696 9507 4611690
Inappropriate antidiuretic hormone secretion 187.00 34.02 78 17717 4436 4616761
Anticonvulsant drug level below therapeutic 186.36 34.02 43 17752 305 4620892
Neutrophil count decreased 186.31 34.02 111 17684 13612 4607585
Urinary incontinence 185.73 34.02 90 17705 7290 4613907
Delusion 185.42 34.02 78 17717 4532 4616665
Learning disorder 183.75 34.02 39 17756 177 4621020
Mental disorder 180.98 34.02 89 17706 7445 4613752
Myoclonic epilepsy 178.93 34.02 45 17750 477 4620720
Psychomotor hyperactivity 175.60 34.02 73 17722 4116 4617081
Foot deformity 175.33 34.02 64 17731 2539 4618658
Maternal exposure during pregnancy 173.57 34.02 115 17680 16978 4604219
Hepatic function abnormal 173.48 34.02 108 17687 14328 4606869
Restlessness 172.90 34.02 93 17702 9376 4611821
Rash maculo-papular 170.53 34.02 89 17706 8440 4612757
Serotonin syndrome 170.34 34.02 84 17711 7068 4614129
Pleural effusion 168.96 34.02 130 17665 24268 4596929
Dysphagia 168.04 34.02 132 17663 25399 4595798
Acidosis hyperchloraemic 163.86 34.02 34 17761 135 4621062
Hallucination, auditory 163.07 34.02 71 17724 4490 4616707
Sopor 162.46 34.02 79 17716 6447 4614750
Microcephaly 162.39 34.02 41 17754 442 4620755
Cryptorchism 160.43 34.02 40 17755 408 4620789
Depressed mood 159.07 34.02 86 17709 8758 4612439
Hypocalcaemia 158.95 34.02 83 17712 7878 4613319
Gamma-glutamyltransferase increased 157.90 34.02 93 17702 11161 4610036
Hallucination, visual 157.69 34.02 75 17720 5827 4615370
Tardive dyskinesia 157.29 34.02 63 17732 3226 4617971
Dizziness 156.73 34.02 242 17553 99629 4521568
Metabolic encephalopathy 156.36 34.02 48 17747 1103 4620094
Motor developmental delay 155.25 34.02 32 17763 122 4621075
Agranulocytosis 154.75 34.02 80 17715 7437 4613760
Dementia 154.24 34.02 71 17724 5121 4616076
Hypomania 153.12 34.02 51 17744 1534 4619663
Talipes 152.89 34.02 47 17748 1085 4620112
Cleft palate 152.50 34.02 42 17753 648 4620549
Drug level above therapeutic 151.60 34.02 47 17748 1117 4620080
Therapeutic response decreased 151.02 34.02 99 17696 14352 4606845
Psychomotor retardation 149.56 34.02 46 17749 1064 4620133
Congenital foot malformation 148.38 34.02 32 17763 159 4621038
Nausea 148.00 34.02 327 17468 177006 4444191
Antipsychotic drug level increased 147.99 34.02 48 17747 1326 4619871
Anticonvulsant drug level above therapeutic 147.22 34.02 35 17760 287 4620910
Apathy 144.59 34.02 57 17738 2798 4618399
Decreased appetite 143.72 34.02 173 17622 56224 4564973
Hypothyroidism 140.02 34.02 76 17719 7798 4613399
Leukocytosis 139.42 34.02 75 17720 7559 4613638
Hypertonia 138.42 34.02 55 17740 2757 4618440
Liver injury 138.24 34.02 65 17730 4920 4616277
Coagulopathy 136.58 34.02 69 17726 6111 4615086
Prominent epicanthal folds 136.49 34.02 24 17771 26 4621171
Sepsis 135.50 34.02 147 17648 42692 4578505
Patent ductus arteriosus 134.83 34.02 47 17748 1627 4619570
C-reactive protein increased 134.42 34.02 88 17707 12724 4608473
Motor dysfunction 134.38 34.02 52 17743 2428 4618769
Intellectual disability 133.79 34.02 34 17761 377 4620820
Decreased eye contact 131.69 34.02 26 17769 75 4621122
Blood alkaline phosphatase increased 131.45 34.02 86 17709 12421 4608776
Congenital hand malformation 131.35 34.02 32 17763 294 4620903
Intentional product misuse 131.21 34.02 100 17695 18393 4602804
Gingival hypertrophy 130.52 34.02 39 17756 815 4620382
Acute kidney injury 129.56 34.02 184 17611 70247 4550950
Product use in unapproved indication 129.43 34.02 113 17682 25160 4596037
Congenital oral malformation 128.52 34.02 25 17770 65 4621132
Focal dyscognitive seizures 126.63 34.02 39 17756 906 4620291
Aphasia 126.19 34.02 74 17721 8806 4612391
Selective eating disorder 125.63 34.02 39 17756 931 4620266
Bradyphrenia 125.52 34.02 46 17749 1845 4619352
Premature baby 125.31 34.02 77 17718 9974 4611223
Jaundice 124.37 34.02 83 17712 12391 4608806
Hypotonia neonatal 124.19 34.02 35 17760 590 4620607
Hypoglycaemia 122.86 34.02 96 17699 18313 4602884
Astigmatism 121.96 34.02 30 17765 288 4620909
Respiratory depression 121.62 34.02 60 17735 5050 4616147
Abortion induced 121.61 34.02 56 17739 4041 4617156
Poisoning deliberate 121.03 34.02 47 17748 2215 4618982
Death 120.97 34.02 324 17471 197839 4423358
Language disorder 120.70 34.02 34 17761 572 4620625
Multiple congenital abnormalities 119.76 34.02 33 17762 510 4620687
Hypokinesia 119.33 34.02 51 17744 3080 4618117
Asthenia 118.89 34.02 197 17598 85966 4535231
Amylase increased 117.58 34.02 48 17747 2582 4618615
Bradycardia 115.73 34.02 101 17694 22468 4598729
Aspiration 115.05 34.02 52 17743 3593 4617604
Ear malformation 114.25 34.02 26 17769 172 4621025
Learning disability 113.24 34.02 24 17771 108 4621089
Miosis 113.21 34.02 48 17747 2842 4618355
Hepatic steatosis 113.20 34.02 61 17734 6167 4615030
Affect lability 112.47 34.02 51 17744 3551 4617646
Oppositional defiant disorder 112.36 34.02 23 17772 84 4621113
Nystagmus 111.26 34.02 45 17750 2363 4618834
Movement disorder 110.43 34.02 55 17740 4724 4616473
Respiratory failure 110.02 34.02 112 17683 30214 4590983
Muscular weakness 109.19 34.02 105 17690 26445 4594752
Arnold-Chiari malformation 109.05 34.02 26 17769 216 4620981
Hyperthermia 108.55 34.02 49 17746 3375 4617822
Renal tubular acidosis 108.03 34.02 33 17762 745 4620452
Acute generalised exanthematous pustulosis 107.76 34.02 47 17748 2983 4618214
Therapeutic response unexpected 107.17 34.02 61 17734 6861 4614336
Akathisia 106.95 34.02 49 17746 3494 4617703
Blister 106.20 34.02 73 17722 11436 4609761
Infantile spasms 104.51 34.02 25 17770 211 4620986
Personality disorder 104.10 34.02 31 17764 640 4620557
Coma scale abnormal 103.35 34.02 38 17757 1538 4619659
Polydactyly 102.17 34.02 29 17766 502 4620695
Thinking abnormal 101.98 34.02 47 17748 3397 4617800
Abdominal pain 101.87 34.02 151 17644 59873 4561324
Bradykinesia 101.08 34.02 35 17760 1187 4620010
Atonic seizures 100.92 34.02 24 17771 197 4621000
Diplopia 100.28 34.02 57 17738 6394 4614803
Antipsychotic drug level decreased 99.97 34.02 24 17771 206 4620991
Haemoglobin decreased 99.94 34.02 118 17677 37539 4583658
Drug level changed 98.80 34.02 25 17770 272 4620925
Medication error 97.97 34.02 76 17719 14340 4606857
Syndactyly 97.73 34.02 25 17770 285 4620912
Headache 97.73 34.02 222 17573 122151 4499046
Psychomotor skills impaired 96.20 34.02 31 17764 838 4620359
Coloboma 96.06 34.02 20 17775 81 4621116
Constipation 95.56 34.02 122 17673 42032 4579165
Hepatomegaly 95.54 34.02 46 17749 3669 4617528
Hepatocellular injury 94.61 34.02 59 17736 7841 4613356
Oedema peripheral 94.40 34.02 121 17674 41851 4579346
Congenital hair disorder 93.77 34.02 16 17779 12 4621185
Cerebellar atrophy 93.48 34.02 25 17770 343 4620854
Mood altered 93.34 34.02 51 17744 5298 4615899
Sudden death 93.29 34.02 51 17744 5304 4615893
Treatment failure 92.71 34.02 73 17722 14074 4607123
Neonatal respiratory distress syndrome 92.53 34.02 36 17759 1705 4619492
Anaemia 92.52 34.02 159 17636 71401 4549796
Respiratory distress 92.07 34.02 66 17729 11050 4610147
Persecutory delusion 92.02 34.02 31 17764 966 4620231
Carnitine deficiency 91.40 34.02 18 17777 51 4621146
General physical health deterioration 91.37 34.02 99 17696 28679 4592518
Weight decreased 90.94 34.02 136 17659 54328 4566869
Dyspraxia 89.92 34.02 21 17774 158 4621039
Mydriasis 88.72 34.02 44 17751 3744 4617453
Bone marrow failure 88.40 34.02 68 17727 12670 4608527
Strabismus 87.54 34.02 29 17766 857 4620340
Renal failure 86.40 34.02 115 17680 41254 4579943
Accidental overdose 86.08 34.02 59 17736 9196 4612001
Shock 85.69 34.02 58 17737 8858 4612339
Gaze palsy 85.41 34.02 27 17768 685 4620512
Withdrawal syndrome 84.72 34.02 51 17744 6363 4614834
Necrosis ischaemic 84.55 34.02 20 17775 160 4621037
Tubulointerstitial nephritis 84.32 34.02 50 17745 6069 4615128
Drug ineffective for unapproved indication 84.06 34.02 49 17746 5762 4615435
Paranoia 83.54 34.02 45 17750 4544 4616653
Feeling abnormal 83.51 34.02 106 17689 36299 4584898
Clonus 83.19 34.02 30 17765 1148 4620049
Congenital eyelid malformation 82.99 34.02 16 17779 39 4621158
Affective disorder 82.51 34.02 33 17762 1682 4619515
Drug intolerance 81.93 34.02 82 17713 21664 4599533
Cogwheel rigidity 81.73 34.02 24 17771 471 4620726
Ileus paralytic 81.25 34.02 34 17761 1947 4619250
Hyperreflexia 81.01 34.02 32 17763 1578 4619619
Hypoalbuminaemia 80.76 34.02 39 17756 3131 4618066
Cerebral ventricle dilatation 80.75 34.02 24 17771 492 4620705
Hypophagia 80.72 34.02 53 17742 7695 4613502
Nipple disorder 80.32 34.02 18 17777 110 4621087
Mitochondrial DNA mutation 80.18 34.02 14 17781 14 4621183
Blood bilirubin increased 80.14 34.02 64 17731 12588 4608609
Asocial behaviour 79.60 34.02 16 17779 52 4621145
Logorrhoea 79.48 34.02 28 17767 1000 4620197
Nervous system disorder 79.47 34.02 49 17746 6382 4614815
Fine motor delay 79.41 34.02 17 17778 81 4621116
Bipolar I disorder 79.35 34.02 25 17770 627 4620570
Granulocytopenia 79.03 34.02 38 17757 3022 4618175
Therapy non-responder 78.88 34.02 70 17725 15907 4605290
Heart disease congenital 78.65 34.02 29 17766 1183 4620014
Tachypnoea 77.96 34.02 44 17751 4867 4616330
Drug withdrawal syndrome 77.93 34.02 63 17732 12609 4608588
Pectus excavatum 77.67 34.02 15 17780 37 4621160
Impulsive behaviour 77.24 34.02 27 17768 942 4620255
High arched palate 77.21 34.02 16 17779 63 4621134
Bicuspid aortic valve 77.18 34.02 19 17776 183 4621014
Malaise 76.89 34.02 168 17627 89989 4531208
Amnesia 76.85 34.02 63 17732 12858 4608339
Hyperkinesia 76.81 34.02 23 17772 484 4620713
Death neonatal 76.64 34.02 23 17772 488 4620709
Subileus 76.46 34.02 28 17767 1120 4620077
Alpers' disease 76.08 34.02 12 17783 1 4621196
Dysgraphia 76.07 34.02 26 17769 847 4620350
Antipsychotic drug level above therapeutic 75.99 34.02 22 17773 410 4620787
Pericarditis 75.70 34.02 38 17757 3317 4617880
Brain herniation 75.56 34.02 29 17766 1323 4619874
Lipase increased 75.52 34.02 38 17757 3334 4617863
Hyperlactacidaemia 75.41 34.02 26 17769 870 4620327
Muscle twitching 75.11 34.02 43 17752 4888 4616309
Priapism 75.07 34.02 30 17765 1526 4619671
Oedema 74.89 34.02 73 17722 18678 4602519
Rash erythematous 74.89 34.02 57 17738 10452 4610745
Antipsychotic drug level below therapeutic 74.67 34.02 20 17775 276 4620921
Musculoskeletal stiffness 74.40 34.02 73 17722 18829 4602368
Dysmetria 74.31 34.02 18 17777 161 4621036
Metabolic disorder 74.26 34.02 29 17766 1387 4619810
Dehydration 74.02 34.02 108 17687 42182 4579015
Nose deformity 73.93 34.02 16 17779 81 4621116
Respiratory acidosis 73.88 34.02 30 17765 1591 4619606
Mood swings 72.77 34.02 44 17751 5533 4615664
Otitis media 72.20 34.02 27 17768 1146 4620051
Hyperhidrosis 71.61 34.02 89 17706 29828 4591369
Communication disorder 71.58 34.02 25 17770 870 4620327
Postictal paralysis 70.86 34.02 15 17780 67 4621130
Cyanosis 70.82 34.02 45 17750 6177 4615020
Haemodynamic instability 70.69 34.02 34 17761 2705 4618492
Akinesia 70.50 34.02 23 17772 647 4620550
Incoherent 70.36 34.02 30 17765 1800 4619397
Erythema multiforme 70.20 34.02 39 17756 4184 4617013
Pallor 69.66 34.02 48 17747 7544 4613653
Blood lactate dehydrogenase increased 69.60 34.02 48 17747 7555 4613642
Drug level fluctuating 69.54 34.02 19 17776 284 4620913
Neurodevelopmental disorder 69.39 34.02 16 17779 113 4621084
Acidosis 69.37 34.02 36 17759 3370 4617827
Pleurothotonus 69.34 34.02 21 17774 460 4620737
Incontinence 69.26 34.02 33 17762 2571 4618626
Pericardial effusion 69.17 34.02 49 17746 8049 4613148
Developmental hip dysplasia 68.67 34.02 20 17775 381 4620816
Osteopenia 68.43 34.02 33 17762 2641 4618556
Liver disorder 67.89 34.02 59 17736 13039 4608158
Acute respiratory distress syndrome 67.76 34.02 47 17748 7466 4613731
Stillbirth 67.60 34.02 30 17765 1984 4619213
Product use issue 67.30 34.02 79 17716 24957 4596240
Diabetes mellitus 66.92 34.02 63 17732 15438 4605759
Therapeutic product effect incomplete 66.87 34.02 66 17729 17142 4604055
Hypersomnia 66.62 34.02 38 17757 4289 4616908
Hypoglycaemia neonatal 66.57 34.02 22 17773 645 4620552
Sinus bradycardia 66.44 34.02 38 17757 4311 4616886
Congenital nail disorder 66.42 34.02 14 17781 61 4621136
Pruritus 66.18 34.02 139 17656 72433 4548764
Hepatic encephalopathy 66.13 34.02 38 17757 4349 4616848
Sinus tachycardia 65.80 34.02 43 17752 6191 4615006
Anaemia macrocytic 65.46 34.02 23 17772 815 4620382
Congenital musculoskeletal anomaly 65.43 34.02 17 17778 207 4620990
Hyperacusis 64.80 34.02 21 17774 578 4620619
Anger 64.79 34.02 41 17754 5588 4615609
Homicidal ideation 64.61 34.02 25 17770 1166 4620031
Schizoaffective disorder 64.23 34.02 20 17775 482 4620715
Neurological decompensation 64.13 34.02 23 17772 866 4620331
Oxygen saturation decreased 64.06 34.02 59 17736 14062 4607135
Gastrointestinal sounds abnormal 63.88 34.02 24 17771 1032 4620165
Staring 63.67 34.02 22 17773 741 4620456
Crying 63.19 34.02 42 17753 6221 4614976
Emotional disorder 62.95 34.02 34 17761 3451 4617746
Blood pressure decreased 62.87 34.02 65 17730 17835 4603362
Propofol infusion syndrome 62.81 34.02 18 17777 323 4620874
Heart rate increased 62.74 34.02 66 17729 18476 4602721
Hyperpyrexia 62.73 34.02 25 17770 1262 4619935
Agitation neonatal 62.07 34.02 19 17776 432 4620765
Head deformity 61.59 34.02 14 17781 92 4621105
Euphoric mood 61.36 34.02 28 17767 1977 4619220
Carnitine decreased 61.20 34.02 12 17783 33 4621164
Disease recurrence 61.20 34.02 44 17751 7397 4613800
Caesarean section 60.85 34.02 38 17757 5060 4616137
Diarrhoea 60.82 34.02 213 17582 149972 4471225
Enuresis 60.22 34.02 22 17773 874 4620323
Anomaly of external ear congenital 60.06 34.02 15 17780 154 4621043
Intestinal ischaemia 59.98 34.02 29 17766 2334 4618863
Resting tremor 59.93 34.02 16 17779 218 4620979
Abdominal distension 59.03 34.02 63 17732 17926 4603271
Dextrocardia 58.79 34.02 13 17782 74 4621123
Visual impairment 58.37 34.02 65 17730 19395 4601802
Lymphadenopathy 58.32 34.02 49 17746 10343 4610854
Glycosuria 58.25 34.02 19 17776 534 4620663
Lactic acidosis 58.25 34.02 52 17743 11904 4609293
Arrhythmia 58.07 34.02 55 17740 13577 4607620
Bruxism 58.05 34.02 23 17772 1143 4620054
Congenital cystic kidney disease 57.31 34.02 16 17779 260 4620937
Septic shock 57.30 34.02 60 17735 16706 4604491
Apnoea 57.11 34.02 31 17764 3177 4618020
Physical assault 56.61 34.02 19 17776 585 4620612
Eosinophil count increased 56.35 34.02 29 17766 2667 4618530
Pancreatitis necrotising 56.25 34.02 20 17775 734 4620463
Face oedema 56.03 34.02 40 17755 6650 4614547
Hypoxia 56.01 34.02 53 17742 13068 4608129
Vasoplegia syndrome 55.98 34.02 17 17778 376 4620821
Anion gap increased 55.94 34.02 19 17776 607 4620590
Congenital cardiovascular anomaly 55.63 34.02 16 17779 291 4620906
Congenital eye disorder 55.41 34.02 13 17782 100 4621097
Orthostatic hypotension 55.05 34.02 40 17755 6834 4614363
Foetal death 54.93 34.02 28 17767 2524 4618673
International normalised ratio increased 54.87 34.02 59 17736 16929 4604268
Haemodialysis 54.76 34.02 35 17760 4852 4616345
Differential white blood cell count abnormal 54.56 34.02 20 17775 802 4620395
Poor sucking reflex 54.54 34.02 14 17781 162 4621035
Cholestasis 54.33 34.02 42 17753 7878 4613319
Tonic convulsion 54.30 34.02 18 17777 533 4620664
Sydenham's chorea 54.28 34.02 10 17785 17 4621180
Depressive symptom 54.20 34.02 21 17774 983 4620214
Psychiatric symptom 53.96 34.02 25 17770 1828 4619369
Lower respiratory tract infection 53.74 34.02 46 17749 9957 4611240
Lymphocyte count increased 53.35 34.02 21 17774 1026 4620171
Gene mutation 53.16 34.02 17 17778 448 4620749
Congenital hearing disorder 52.94 34.02 11 17784 44 4621153
Posture abnormal 52.84 34.02 20 17775 878 4620319
Clinodactyly 52.39 34.02 12 17783 82 4621115
Sleep apnoea syndrome 52.27 34.02 33 17762 4478 4616719
Abdominal tenderness 52.20 34.02 24 17771 1724 4619473
Camptodactyly congenital 51.97 34.02 10 17785 24 4621173
Mobility decreased 51.96 34.02 51 17744 13154 4608043
Proteinuria 51.75 34.02 38 17757 6598 4614599
Ligament laxity 51.69 34.02 10 17785 25 4621172
Loss of personal independence in daily activities 51.32 34.02 41 17754 8064 4613133
Conductive deafness 50.73 34.02 12 17783 96 4621101
Procalcitonin increased 50.58 34.02 15 17780 305 4620892
Snoring 50.56 34.02 20 17775 990 4620207
Ileus 50.39 34.02 34 17761 5162 4616035
Systemic inflammatory response syndrome 50.38 34.02 24 17771 1869 4619328
Micrognathia 50.35 34.02 14 17781 224 4620973
Product dispensing error 50.34 34.02 36 17759 6001 4615196
Cardiac murmur 50.20 34.02 28 17767 3027 4618170
Neutrophil count increased 50.05 34.02 33 17762 4822 4616375
Disturbance in social behaviour 49.95 34.02 16 17779 424 4620773
Polycystic ovaries 49.89 34.02 14 17781 232 4620965
Electrocardiogram abnormal 49.81 34.02 27 17768 2759 4618438
Inguinal hernia 49.45 34.02 22 17773 1463 4619734
Asphyxia 49.43 34.02 25 17770 2217 4618980
Apraxia 49.38 34.02 17 17778 566 4620631
Faecaloma 49.34 34.02 23 17772 1705 4619492
Intra-abdominal pressure increased 49.18 34.02 10 17785 35 4621162
Foetal growth restriction 49.06 34.02 26 17769 2540 4618657
Adverse drug reaction 49.03 34.02 52 17743 14687 4606510
Contusion 48.83 34.02 59 17736 19199 4601998
Small for dates baby 48.81 34.02 24 17771 2003 4619194
Nasal septum disorder 48.43 34.02 11 17784 72 4621125
Renal hypoplasia 48.43 34.02 11 17784 72 4621125
Vanishing bile duct syndrome 47.80 34.02 15 17780 371 4620826
Lennox-Gastaut syndrome 47.74 34.02 10 17785 42 4621155
Unevaluable event 47.64 34.02 54 17741 16422 4604775
Hypotelorism of orbit 47.57 34.02 9 17786 19 4621178
Drug eruption 47.45 34.02 36 17759 6567 4614630
Myopia 47.40 34.02 17 17778 640 4620557
Hypertension 47.09 34.02 98 17697 50700 4570497
Hypokalaemia 46.79 34.02 57 17738 18703 4602494
Myoglobinuria 46.78 34.02 14 17781 294 4620903
Idiosyncratic drug reaction 46.77 34.02 15 17780 399 4620798
Postural tremor 46.61 34.02 11 17784 87 4621110
Distractibility 46.29 34.02 13 17782 216 4620981
Kidney malformation 45.97 34.02 12 17783 149 4621048
Hyperglycinaemia 45.82 34.02 8 17787 8 4621189
Nikolsky's sign 45.53 34.02 13 17782 230 4620967
Drop attacks 45.21 34.02 14 17781 331 4620866
Adverse event 45.07 34.02 52 17743 16120 4605077
Dermatitis exfoliative 45.04 34.02 26 17769 3000 4618197
Hypoacusis 44.46 34.02 34 17761 6275 4614922
Vascular parkinsonism 44.44 34.02 8 17787 11 4621186
Haemangioma 44.26 34.02 17 17778 777 4620420
Homicide 44.26 34.02 15 17780 476 4620721
Areflexia 43.86 34.02 19 17776 1185 4620012
Obsessive-compulsive disorder 43.85 34.02 21 17774 1654 4619543
Cardiometabolic syndrome 43.85 34.02 16 17779 633 4620564
Craniofacial deformity 43.70 34.02 10 17785 68 4621129
Prothrombin time shortened 43.36 34.02 16 17779 654 4620543
Blood albumin decreased 43.28 34.02 27 17768 3587 4617610
Microstomia 43.27 34.02 8 17787 14 4621183
Retinal coloboma 43.27 34.02 8 17787 14 4621183
Basilar artery occlusion 43.08 34.02 10 17785 73 4621124
Drug withdrawal convulsions 43.06 34.02 16 17779 667 4620530
Congenital hydrocephalus 43.04 34.02 12 17783 194 4621003
Drug withdrawal syndrome neonatal 42.96 34.02 21 17774 1731 4619466
Anisometropia 42.92 34.02 8 17787 15 4621182
Illiteracy 42.92 34.02 8 17787 15 4621182
Meningocele 42.73 34.02 10 17785 76 4621121
Hyperprolactinaemia 42.66 34.02 18 17777 1052 4620145
Refusal of treatment by patient 42.59 34.02 24 17771 2646 4618551
Poor quality sleep 42.56 34.02 26 17769 3329 4617868
Limbic encephalitis 42.50 34.02 10 17785 78 4621119
Infection 42.36 34.02 77 17718 36065 4585132
Neural tube defect 42.18 34.02 11 17784 136 4621061
Psychiatric decompensation 42.09 34.02 15 17780 554 4620643
Irregular sleep phase 42.02 34.02 9 17786 43 4621154
Neurotoxicity 41.91 34.02 31 17764 5442 4615755
Educational problem 41.68 34.02 13 17782 315 4620882
Head injury 41.68 34.02 35 17760 7380 4613817
Joint dislocation 41.67 34.02 22 17773 2132 4619065
Anal incontinence 41.61 34.02 25 17770 3106 4618091
Growth retardation 41.60 34.02 17 17778 916 4620281
Intracranial pressure increased 41.51 34.02 21 17774 1863 4619334
Petechiae 41.20 34.02 27 17768 3904 4617293
Labelled drug-drug interaction medication error 41.19 34.02 25 17770 3163 4618034
Panic attack 40.77 34.02 32 17763 6135 4615062
Incorrect dose administered 40.60 34.02 54 17741 19331 4601866
Therapeutic product cross-reactivity 40.50 34.02 16 17779 789 4620408
Polydipsia 40.41 34.02 19 17776 1436 4619761
Wrist deformity 40.28 34.02 11 17784 164 4621033
Febrile convulsion 40.25 34.02 13 17782 354 4620843
Cardiomegaly 39.94 34.02 29 17766 4948 4616249
Choreoathetosis 39.94 34.02 13 17782 363 4620834
Plagiocephaly 39.91 34.02 11 17784 170 4621027
Terminal insomnia 39.44 34.02 12 17783 267 4620930
Hyporeflexia 39.30 34.02 16 17779 854 4620343
Coma hepatic 39.24 34.02 13 17782 384 4620813
Mutism 39.24 34.02 14 17781 519 4620678
Trismus 39.21 34.02 19 17776 1536 4619661
Prothrombin time prolonged 39.17 34.02 25 17770 3456 4617741
Skin lesion 39.16 34.02 34 17761 7499 4613698
C-reactive protein decreased 39.16 34.02 11 17784 183 4621014
Pupillary reflex impaired 39.02 34.02 16 17779 870 4620327
Pneumatosis 38.94 34.02 11 17784 187 4621010
Slow response to stimuli 38.74 34.02 13 17782 400 4620797
Wrong patient received product 38.71 34.02 14 17781 540 4620657
Deafness 38.71 34.02 29 17766 5190 4616007
Eye movement disorder 38.68 34.02 21 17774 2153 4619044
Cerebellar hypoplasia 38.62 34.02 9 17786 67 4621130
Joint instability 38.55 34.02 12 17783 289 4620908
Blood osmolarity increased 38.54 34.02 10 17785 121 4621076
Blood sodium decreased 38.49 34.02 30 17765 5692 4615505
Joint contracture 38.25 34.02 13 17782 416 4620781
Vascular encephalopathy 38.10 34.02 10 17785 127 4621070
Fanconi syndrome acquired 38.08 34.02 15 17780 734 4620463
Haematocrit decreased 37.80 34.02 36 17759 8946 4612251
Central nervous system lesion 37.78 34.02 24 17771 3291 4617906
Blood creatinine increased 37.66 34.02 62 17733 26838 4594359
Hypermetropia 37.50 34.02 11 17784 215 4620982
Pancreatic pseudocyst 37.39 34.02 12 17783 320 4620877
Therapeutic product effect decreased 37.39 34.02 51 17744 18702 4602495
Gait inability 37.34 34.02 37 17758 9648 4611549
Transient aphasia 37.26 34.02 7 17788 14 4621183
Increased appetite 37.23 34.02 22 17773 2651 4618546
Normochromic normocytic anaemia 37.23 34.02 18 17777 1448 4619749
Blood prolactin increased 37.04 34.02 19 17776 1735 4619462
Hydrocephalus 36.96 34.02 20 17775 2037 4619160
Developmental regression 36.93 34.02 7 17788 15 4621182
Ovarian granulosa-theca cell tumour 36.93 34.02 7 17788 15 4621182
Blood glucose increased 36.91 34.02 58 17737 24146 4597051
Dyspnoea 36.90 34.02 173 17622 138812 4482385
Hepatic necrosis 36.82 34.02 20 17775 2052 4619145
Sluggishness 36.74 34.02 19 17776 1765 4619432
Vitamin D decreased 36.71 34.02 18 17777 1493 4619704
Hypersensitivity 36.63 34.02 75 17720 38346 4582851
Porphyria acute 36.62 34.02 10 17785 149 4621048
Conjunctival hyperaemia 36.61 34.02 17 17778 1249 4619948
Erectile dysfunction 36.49 34.02 27 17768 4742 4616455
Hypertransaminasaemia 36.43 34.02 17 17778 1263 4619934
Activated partial thromboplastin time prolonged 36.37 34.02 22 17773 2767 4618430
Feeling of despair 36.36 34.02 14 17781 644 4620553
Blood pH decreased 36.34 34.02 16 17779 1038 4620159
Use of accessory respiratory muscles 36.32 34.02 10 17785 154 4621043
Delusional disorder, unspecified type 36.32 34.02 11 17784 241 4620956
Renal tubular disorder 36.30 34.02 18 17777 1530 4619667
Product quality issue 36.11 34.02 52 17743 20047 4601150
Gastrointestinal malformation 36.07 34.02 9 17786 92 4621105
Hypoventilation 36.06 34.02 17 17778 1293 4619904
Major depression 35.97 34.02 19 17776 1843 4619354
Vision blurred 35.85 34.02 58 17737 24745 4596452
Gingival bleeding 35.84 34.02 24 17771 3597 4617600
Hypophosphataemia 35.79 34.02 22 17773 2847 4618350
Failure to thrive 35.64 34.02 20 17775 2187 4619010
Atelectasis 35.59 34.02 25 17770 4050 4617147
Automatism 35.47 34.02 9 17786 99 4621098
Respiratory rate increased 35.42 34.02 22 17773 2901 4618296
Disseminated intravascular coagulation 35.40 34.02 32 17763 7441 4613756
Dermatitis bullous 35.25 34.02 22 17773 2925 4618272
Synostosis 35.14 34.02 8 17787 53 4621144
Red blood cell sedimentation rate increased 35.07 34.02 23 17772 3330 4617867
Stereotypy 35.06 34.02 11 17784 272 4620925
Bilirubin conjugated increased 35.05 34.02 16 17779 1130 4620067
Obstructive airways disorder 35.03 34.02 21 17774 2599 4618598
Subarachnoid haemorrhage 34.92 34.02 25 17770 4173 4617024
Hepatitis cholestatic 34.89 34.02 21 17774 2617 4618580
Lipids 34.88 34.02 6 17789 5 4621192
Conversion disorder 34.80 34.02 13 17782 550 4620647
Bladder sphincter atony 34.76 34.02 8 17787 56 4621141
Platelet count increased 34.59 34.02 25 17770 4235 4616962
Nervousness 34.26 34.02 32 17763 7760 4613437
Limb hypoplasia congenital 34.16 34.02 8 17787 61 4621136
Dysphoria 34.15 34.02 21 17774 2720 4618477
Cerebral disorder 34.08 34.02 16 17779 1205 4619992
Hypoxic-ischaemic encephalopathy 34.03 34.02 18 17777 1751 4619446

Pharmacologic Action:

SourceCodeDescription
ATC N03AG01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
CHEBI has role CHEBI:51374 GABA agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35471 psychotropic drug
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:35477 antimanic drug
FDA EPC N0000175753 Anti-epileptic Agent
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
FDA EPC N0000175751 Mood Stabilizer
MeSH PA D000927 Anticonvulsants
MeSH PA D018692 Antimanic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018682 GABA Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Absence seizure indication 79631006
Epilepsy indication 84757009 DOID:1826
Bipolar affective disorder, current episode manic indication 191618007
Epilepsy characterized by intractable complex partial seizures indication 442481002
Migraine Prevention indication
Bipolar disorder off-label use 13746004 DOID:3312
Mixed bipolar I disorder off-label use 16506000 DOID:3312
Myoclonic seizure off-label use 37356005
Bipolar disorder in remission off-label use 85248005
Seizure disorder off-label use 128613002
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Tonic-clonic epilepsy off-label use 352818000 DOID:7725
Simple partial seizure off-label use 117891000119100
Rapid Cycling Bipolar Affective Disorder off-label use
Suicidal thoughts contraindication 6471006
Hyperammonemia contraindication 9360008
Arginase deficiency contraindication 23501004 DOID:9278
Depressive disorder contraindication 35489007
Congenital hyperammonemia, type I contraindication 62522004
Kidney disease contraindication 90708001 DOID:557
Organic mental disorder contraindication 111479008
Hypoalbuminemia contraindication 119247004
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Acute pancreatitis contraindication 197456007 DOID:2913
Chronic pancreatitis contraindication 235494005
Disease of liver contraindication 235856003 DOID:409
Poisoning by sodium valproate contraindication 241754000
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Hypothermia contraindication 386689009
Citrullinemia contraindication 398680004 DOID:9273
Porphyria contraindication 418470004
Ornithine Carbamyltransferase Deficiency contraindication
Arginosuccinate Lyase Deficiency contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.97 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Succinate-semialdehyde dehydrogenase, mitochondrial Enzyme INHIBITOR CHEMBL CHEMBL
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.30 CHEMBL
Histone deacetylase 2 Enzyme IC50 4.21 CHEMBL
UDP-glucuronosyltransferase 1-5 Enzyme WOMBAT-PK
Histone deacetylase 1 Enzyme INHIBITOR IC50 6.40 IUPHAR
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.05 CHEMBL
Alcohol dehydrogenase [NADP(+)] Enzyme IC50 4.30 CHEMBL
Aldose reductase Enzyme IC50 4.24 CHEMBL
Aldose reductase Enzyme IC50 4.25 CHEMBL
Aldose reductase-related protein 1 Unclassified IC50 4.25 CHEMBL

External reference:

IDSource
4022507 VUID
N0000147028 NUI
C0042291 UMLSCUI
D00304 KEGG_DRUG
56CCK4F86G UNII
33433-82-8 SECONDARY_CAS_RN
3300 INN_ID
387080000 SNOMEDCT_US
13965000 SNOMEDCT_US
4018723 VANDF
4022507 VANDF
3118 MMSL
11118 RXNORM
5662 MMSL
d00083 MMSL
17039 MMSL
001622 NDDF
3121 PUBCHEM_CID
CHEBI:39867 CHEBI
CHEMBL433 ChEMBL_ID
CHEMBL109 ChEMBL_ID
DB00313 DRUGBANK_ID
D014635 MESH_DESCRIPTOR_UI
CHEMBL2105613 ChEMBL_ID
CHEMBL2315212 ChEMBL_ID
7009 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-3826 TABLET, EXTENDED RELEASE 250 mg ORAL NDA 20 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6114 CAPSULE 125 mg ORAL NDA 20 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6212 TABLET, DELAYED RELEASE 125 mg ORAL NDA 20 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6214 TABLET, DELAYED RELEASE 250 mg ORAL NDA 20 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-6215 TABLET, DELAYED RELEASE 500 mg ORAL NDA 20 sections
Depakote HUMAN PRESCRIPTION DRUG LABEL 1 0074-7126 TABLET, EXTENDED RELEASE 500 mg ORAL NDA 20 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-0675 SOLUTION 250 mg ORAL ANDA 21 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-1350 SOLUTION 500 mg ORAL ANDA 21 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0121-4675 SOLUTION 250 mg ORAL ANDA 21 sections
Valproate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9637 INJECTION 100 mg INTRAVENOUS ANDA 18 sections
Valproate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9785 INJECTION 500 mg INTRAVENOUS ANDA 19 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-0472 TABLET, FILM COATED, EXTENDED RELEASE 250 mg ORAL ANDA 20 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-0473 TABLET, FILM COATED, EXTENDED RELEASE 500 mg ORAL ANDA 20 sections
VALPROIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0527-5250 SOLUTION 250 mg ORAL ANDA 20 sections
Valproic HUMAN PRESCRIPTION DRUG LABEL 1 0591-4012 CAPSULE, LIQUID FILLED 250 mg ORAL ANDA 20 sections
Valproic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-1325 CAPSULE 250 mg ORAL ANDA 15 sections
Divalproex sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-1393 CAPSULE 125 mg ORAL ANDA 19 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7531 TABLET, DELAYED RELEASE 125 mg ORAL ANDA 20 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7532 TABLET, DELAYED RELEASE 250 mg ORAL ANDA 20 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7533 TABLET, DELAYED RELEASE 500 mg ORAL ANDA 20 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7554 TABLET, FILM COATED, EXTENDED RELEASE 250 mg ORAL ANDA 20 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7555 TABLET, FILM COATED, EXTENDED RELEASE 500 mg ORAL ANDA 20 sections
Valproic HUMAN PRESCRIPTION DRUG LABEL 1 0615-7840 CAPSULE, LIQUID FILLED 250 mg ORAL ANDA 18 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7848 TABLET, DELAYED RELEASE 125 mg ORAL ANDA 21 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7849 TABLET, DELAYED RELEASE 250 mg ORAL ANDA 20 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7850 TABLET, DELAYED RELEASE 500 mg ORAL ANDA 20 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7949 TABLET, DELAYED RELEASE 250 mg ORAL ANDA 20 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7950 TABLET, DELAYED RELEASE 500 mg ORAL ANDA 20 sections
Divalproex Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7956 TABLET, DELAYED RELEASE 125 mg ORAL ANDA 20 sections
Valproic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0615-8205 CAPSULE, LIQUID FILLED 250 mg ORAL ANDA 19 sections