valpromide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2804 2430-27-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • valpromide
  • 2-propylpentamide
  • dipropylacetamide
  • Molecular weight: 143.23
  • Formula: C8H17NO
  • CLOGP: 1.84
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 43.09
  • ALOGS: -1.61
  • ROTB: 5

Drug dosage:

DoseUnitRoute
1.50 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 68 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Poisoning deliberate 126.52 56.72 31 1081 11187 63476723
Coma 119.20 56.72 44 1068 64320 63423590
Suicide attempt 68.19 56.72 29 1083 60889 63427021
Bradycardia 66.23 56.72 30 1082 73197 63414713
Alkalosis hypochloraemic 63.33 56.72 9 1103 158 63487752
Toxicity to various agents 60.72 56.72 43 1069 247207 63240703

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Meningioma 87.22 61.36 16 608 1420 34954887

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Poisoning deliberate 143.61 52.73 40 1717 18788 79723843
Coma 102.41 52.73 48 1709 100601 79642030
Hypothermia 69.51 52.73 24 1733 22722 79719909
Suicide attempt 64.60 52.73 33 1724 82899 79659732
Hypometabolism 55.02 52.73 8 1749 130 79742501
Toxicity to various agents 54.53 52.73 56 1701 421484 79321147

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AG02 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.58 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02766 KEGG_DRUG
1116-24-1 SECONDARY_CAS_RN
C0058426 UMLSCUI
VPR PDB_CHEM_ID
CHEMBL93836 ChEMBL_ID
DB04165 DRUGBANK_ID
71113 PUBCHEM_CID
4365 INN_ID
C004651 MESH_SUPPLEMENTAL_RECORD_UI
RUA6CWU76G UNII
23420 RXNORM
005370 NDDF
698808002 SNOMEDCT_US

Pharmaceutical products:

None