progabide Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
gabamimetic agents 2278 62666-20-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • progabide
  • halogabide
  • gabrene
  • gabren
GABA agonist; structure
  • Molecular weight: 334.78
  • Formula: C17H16ClFN2O2
  • CLOGP: 2.90
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 75.68
  • ALOGS: -4.68
  • ROTB: 6

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1985 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AG05 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000927 Anticonvulsants
MeSH PA D000928 Antidepressive Agents
MeSH PA D000978 Antiparkinson Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018682 GABA Agents
MeSH PA D018755 GABA Agonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.28 acidic
pKa2 13.0 acidic
pKa3 3.38 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel Ki 4.40 WOMBAT-PK
GABA-A receptor; anion channel Ion channel Ki 4.40 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 4.85 CHEMBL

External reference:

IDSource
C0072076 UMLSCUI
D05621 KEGG_DRUG
38C836J57Z UNII
4656 INN_ID
34568 RXNORM
005334 NDDF
CHEMBL287631 ChEMBL_ID
C017985 MESH_SUPPLEMENTAL_RECORD_UI
DB00837 DRUGBANK_ID
CHEBI:135422 CHEBI
44115 PUBCHEM_CID

Pharmaceutical products:

None