efonidipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| calcium channel blockers, nifedipine derivatives | 992 | 111011-63-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002121 | Calcium Channel Blockers |
| MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004232 | Diuretics |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D045283 | Natriuretic Agents |
| CHEBI has role | CHEBI:35620 | vasodilator agents |
| CHEBI has role | CHEBI:35674 | antihypertensive drugs |
| CHEBI has role | CHEBI:38215 | calcium channel blockers |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.96 | Basic |
| pKa2 | 2.26 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Voltage-gated L-type calcium channel | Ion channel | BLOCKER | DRUG LABEL | SCIENTIFIC LITERATURE | |||||
| Voltage-dependent T-type calcium channel subunit alpha-1H | Ion channel | BLOCKER | IC50 | 6.62 | SCIENTIFIC LITERATURE | ||||
| Voltage-dependent T-type calcium channel subunit alpha-1G | Ion channel | BLOCKER | IC50 | 7 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| D07886 | KEGG_DRUG |
| C0286819 | UMLSCUI |
| CHEBI:135859 | CHEBI |
| CHEMBL2074922 | ChEMBL_ID |
| DB09235 | DRUGBANK_ID |
| C066425 | MESH_SUPPLEMENTAL_RECORD_UI |
| 12565 | IUPHAR_LIGAND_ID |
| 6852 | INN_ID |
| 111011-53-1 | SECONDARY_CAS_RN |
| 40ZTP2T37Q | UNII |
| 119171 | PUBCHEM_CID |
| 010907 | NDDF |
| 010908 | NDDF |
Pharmaceutical products:
None