efonidipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 992 111011-63-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • efonidipine
  • efonidipine hydrochloride
  • zeria
  • efonidipine HCl
  • Molecular weight: 631.67
  • Formula: C34H38N3O7P
  • CLOGP: 6.54
  • LIPINSKI: 2
  • HAC: 10
  • HDO: 1
  • TPSA: 120.24
  • ALOGS: -6.41
  • ROTB: 11

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:38215 calcium channel blockers

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.96 Basic
pKa2 2.26 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER DRUG LABEL SCIENTIFIC LITERATURE
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel BLOCKER IC50 6.62 SCIENTIFIC LITERATURE
Voltage-dependent T-type calcium channel subunit alpha-1G Ion channel BLOCKER IC50 7 IUPHAR

External reference:

IDSource
D07886 KEGG_DRUG
111011-53-1 SECONDARY_CAS_RN
C0286819 UMLSCUI
CHEBI:135859 CHEBI
CHEMBL2074922 ChEMBL_ID
DB09235 DRUGBANK_ID
C066425 MESH_SUPPLEMENTAL_RECORD_UI
6852 INN_ID
40ZTP2T37Q UNII
119171 PUBCHEM_CID
010907 NDDF
010908 NDDF

Pharmaceutical products:

None