ebrotidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
histamine-H2-receptor antagonists, cimetidine derivatives	979	100981-43-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

FI-3542
ebrotidine
ebrodin
ulsanic

an H2-receptor antagonist and gastric mucosa protector

Molecular weight: 477.41
Formula: C14H17BrN6O2S3
CLOGP: 1.12
LIPINSKI: 0
HAC: 8
HDO: 4
TPSA: 133.32
ALOGS: -4.25
ROTB: 7

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Hosey CM, Chan R, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000897	Anti-Ulcer Agents
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D018494	Histamine Agents
MeSH PA	D006633	Histamine Antagonists
MeSH PA	D006635	Histamine H2 Antagonists
MeSH PA	D018377	Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.63	Basic
pKa2	2.56	Basic
pKa3	0.47	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Histamine H2 receptor	GPCR	P25021	HRH2_HUMAN	ANTAGONIST				SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
C0169307	UMLSCUI
CHEBI:135774	CHEBI
CHEMBL1742471	ChEMBL_ID
C075156	MESH_SUPPLEMENTAL_RECORD_UI
6009	INN_ID
TMZ3IBW2OW	UNII
65869	PUBCHEM_CID
D013392	MESH_DESCRIPTOR_UI
CHEMBL3989780	ChEMBL_ID

Pharmaceutical products:

None