doxorubicin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastics, daunorubicin derivatives 960 23214-92-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • doxorubicin
  • hydroxydaunomycin
  • hydroxydaunorubicin
  • rubidox
  • doxorubicin hydrochloride
  • liposomal doxorubicin
  • hydroxydaunorubicin hydrochloride
  • adriamycin
  • doxorubicin HCl
  • hydroxydaunorubicin HCl
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
  • Molecular weight: 543.53
  • Formula: C27H29NO11
  • CLOGP: 0.26
  • LIPINSKI: 3
  • HAC: 12
  • HDO: 6
  • TPSA: 206.07
  • ALOGS: -2.67
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 3.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.47 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 5 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 15 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.28 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 32 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 7, 1974 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 4780.46 12.98 2671 89369 94996 50418088
Neutropenia 2549.90 12.98 2123 89917 145842 50367242
Acute myeloid leukaemia 1089.33 12.98 537 91503 14537 50498547
Cardiotoxicity 915.78 12.98 378 91662 6649 50506435
Mucosal inflammation 912.44 12.98 680 91360 39462 50473622
Disease progression 843.33 12.98 953 91087 94913 50418171
Myelodysplastic syndrome 802.49 12.98 438 91602 14694 50498390
Thrombocytopenia 796.15 12.98 1067 90973 126606 50386478
Second primary malignancy 781.04 12.98 336 91704 6578 50506506
Haematotoxicity 776.32 12.98 348 91692 7547 50505537
Palmar-plantar erythrodysaesthesia syndrome 707.15 12.98 446 91594 19652 50493432
Malignant neoplasm progression 662.29 12.98 714 91326 67410 50445674
Product use in unapproved indication 640.77 12.98 914 91126 114905 50398179
Bone marrow failure 565.83 12.98 440 91600 27184 50485900
Pancytopenia 547.41 12.98 718 91322 83312 50429772
Cardiomyopathy 496.59 12.98 325 91715 15261 50497823
Diffuse large B-cell lymphoma recurrent 492.69 12.98 162 91878 1433 50511651
Ejection fraction decreased 491.86 12.98 345 91695 18175 50494909
Febrile bone marrow aplasia 468.19 12.98 229 91811 6082 50507002
Off label use 465.34 12.98 1896 90144 472530 50040554
Neoplasm progression 439.81 12.98 389 91651 28768 50484316
Anaemia 402.45 12.98 1187 90853 251269 50261815
Pneumocystis jirovecii pneumonia 368.18 12.98 264 91776 14399 50498685
Joint swelling 368.15 12.98 19 92021 245267 50267817
Metastases to bone 351.94 12.98 279 91761 17716 50495368
Rheumatoid arthritis 342.62 12.98 5 92035 202545 50310539
Ovarian failure 323.78 12.98 108 91932 1003 50512081
Neuropathy peripheral 312.90 12.98 600 91440 96157 50416927
Leukopenia 303.27 12.98 484 91556 67044 50446040
Left ventricular dysfunction 303.12 12.98 206 91834 10300 50502784
Cardiac failure 302.48 12.98 516 91524 75524 50437560
Tumour lysis syndrome 299.93 12.98 180 91860 7241 50505843
Pain 277.98 12.98 390 91650 578513 49934571
Fall 276.55 12.98 132 91908 334800 50178284
Septic shock 273.64 12.98 422 91618 56753 50456331
Abdominal discomfort 265.49 12.98 50 91990 231591 50281493
Pyrexia 261.38 12.98 1371 90669 378832 50134252
Neutrophil count decreased 261.05 12.98 368 91672 45658 50467426
Metastases to lung 250.81 12.98 187 91853 10833 50502251
Myelosuppression 243.99 12.98 200 91840 13317 50499767
Metastases to liver 240.86 12.98 236 91804 19868 50493216
Contraindicated product administered 238.71 12.98 7 92033 148951 50364133
Systemic lupus erythematosus 235.48 12.98 4 92036 140618 50372466
Bone pain 235.02 12.98 355 91685 46874 50466210
Sepsis 234.54 12.98 649 91391 132276 50380808
Neutropenic sepsis 233.97 12.98 199 91841 13948 50499136
Completed suicide 224.04 12.98 3 92037 131886 50381198
Headache 221.90 12.98 363 91677 506172 50006912
Hepatitis B reactivation 221.20 12.98 97 91943 1990 50511094
Diffuse large B-cell lymphoma refractory 221.05 12.98 80 91960 966 50512118
Congestive cardiomyopathy 220.81 12.98 133 91907 5385 50507699
Weight increased 214.10 12.98 52 91988 201839 50311245
Product dose omission issue 212.04 12.98 39 92001 183799 50329285
Peripheral swelling 210.79 12.98 57 91983 205879 50307205
Arthropathy 201.54 12.98 25 92015 157881 50355203
Drug hypersensitivity 199.37 12.98 104 91936 250906 50262178
Staphylococcal bacteraemia 198.91 12.98 119 91921 4758 50508326
Arthralgia 198.04 12.98 308 91732 438394 50074690
Swelling 197.46 12.98 60 91980 200812 50312272
Nasopharyngitis 194.45 12.98 55 91985 192872 50320212
Synovitis 194.24 12.98 7 92033 123858 50389226
Acute promyelocytic leukaemia 192.02 12.98 69 91971 815 50512269
Neutropenic colitis 186.16 12.98 90 91950 2327 50510757
Pruritus 182.47 12.98 149 91891 283419 50229665
Musculoskeletal stiffness 180.53 12.98 14 92026 128467 50384617
Disease recurrence 178.45 12.98 201 91839 19880 50493204
Posterior reversible encephalopathy syndrome 178.36 12.98 175 91865 14753 50498331
Therapeutic product effect decreased 172.48 12.98 22 92018 136028 50377056
Cytopenia 169.29 12.98 135 91905 8640 50504444
Therapy partial responder 168.49 12.98 120 91920 6471 50506613
Sinusitis 162.16 12.98 54 91986 170504 50342580
Ascites 156.73 12.98 254 91786 35607 50477477
Hepatitis B 155.62 12.98 90 91950 3376 50509708
Metastases to lymph nodes 154.95 12.98 117 91923 6907 50506177
Neurotoxicity 154.53 12.98 161 91879 14579 50498505
Wound 144.56 12.98 13 92027 105781 50407303
Dizziness 144.21 12.98 256 91784 346113 50166971
Rash 144.13 12.98 369 91671 437102 50075982
Anti-Muellerian hormone level decreased 142.71 12.98 34 92006 70 50513014
Pleural effusion 141.83 12.98 396 91644 81058 50432026
Injection site pain 135.87 12.98 20 92020 111004 50402080
Drug intolerance 134.90 12.98 120 91920 218984 50294100
Peripheral sensory neuropathy 134.89 12.98 105 91935 6486 50506598
Interstitial lung disease 133.16 12.98 297 91743 52879 50460205
Post transplant lymphoproliferative disorder 129.81 12.98 86 91954 4118 50508966
Insomnia 127.94 12.98 80 91960 174785 50338299
Stomatitis 125.78 12.98 438 91602 100906 50412178
Pneumonitis 124.86 12.98 206 91834 29304 50483780
Drug ineffective 122.97 12.98 931 91109 818402 49694682
Aplasia 122.60 12.98 80 91960 3733 50509351
Multiple organ dysfunction syndrome 118.10 12.98 274 91766 50063 50463021
Contusion 116.69 12.98 30 92010 112153 50400931
Discomfort 114.63 12.98 28 92012 108352 50404732
Progressive multifocal leukoencephalopathy 114.50 12.98 122 91918 11335 50501749
Platelet count decreased 114.48 12.98 423 91617 100303 50412781
B-cell lymphoma recurrent 112.77 12.98 38 92002 365 50512719
Somnolence 109.15 12.98 74 91966 154911 50358173
Urticaria 108.32 12.98 50 91990 129511 50383573
Muscle spasms 107.24 12.98 47 91993 125506 50387578
Feeling abnormal 107.15 12.98 47 91993 125445 50387639
Acute lymphocytic leukaemia recurrent 106.95 12.98 58 91982 1917 50511167
Lymphadenopathy 105.99 12.98 206 91834 33293 50479791
Polyneuropathy 103.65 12.98 119 91921 12012 50501072
Breast cancer recurrent 103.53 12.98 72 91968 3736 50509348
White blood cell count decreased 102.95 12.98 453 91587 116269 50396815
Pain in extremity 101.87 12.98 215 91825 272650 50240434
Overdose 101.20 12.98 28 92012 99699 50413385
Breast cancer metastatic 101.17 12.98 109 91931 10255 50502829
Metastases to central nervous system 100.35 12.98 113 91927 11169 50501915
Hepatic enzyme increased 100.26 12.98 63 91977 137317 50375767
Arthritis 98.62 12.98 19 92021 86702 50426382
Anxiety 98.06 12.98 107 91933 177499 50335585
Haemophagocytic lymphohistiocytosis 97.20 12.98 98 91942 8535 50504549
Small intestinal obstruction 96.31 12.98 132 91908 15936 50497148
Skin toxicity 94.88 12.98 69 91971 3844 50509240
Premature menopause 94.50 12.98 40 92000 750 50512334
Premature delivery 91.90 12.98 159 91881 23504 50489580
Blood pressure increased 91.83 12.98 65 91975 133067 50380017
Pericarditis 87.88 12.98 18 92022 78671 50434413
Injection site erythema 83.98 12.98 17 92023 74919 50438165
Hospitalisation 83.65 12.98 12 92028 67925 50445159
Epstein-Barr virus infection 83.52 12.98 82 91958 6915 50506169
Drug resistance 82.27 12.98 134 91906 18855 50494229
Neoplasm recurrence 81.83 12.98 52 91988 2317 50510767
Confusional state 81.28 12.98 133 91907 185795 50327289
Bacteraemia 81.18 12.98 115 91925 14318 50498766
Malaise 80.94 12.98 325 91715 335207 50177877
Asthma 80.23 12.98 31 92009 89306 50423778
Smooth muscle cell neoplasm 79.01 12.98 35 92005 736 50512348
Respiratory failure 78.95 12.98 352 91688 90829 50422255
Metastases to peritoneum 78.04 12.98 54 91986 2779 50510305
Gene mutation 76.36 12.98 40 92000 1231 50511853
Gait disturbance 75.69 12.98 97 91943 149908 50363176
Depression 75.46 12.98 115 91925 165308 50347776
Metastasis 75.32 12.98 63 91977 4312 50508772
Irritable bowel syndrome 73.96 12.98 5 92035 51436 50461648
Ileus 73.80 12.98 105 91935 13124 50499960
Neutrophil count abnormal 72.78 12.98 49 91991 2410 50510674
Condition aggravated 72.71 12.98 286 91754 296772 50216312
Metastases to breast 72.59 12.98 25 92015 258 50512826
Systemic candida 69.48 12.98 50 91990 2740 50510344
Myeloid leukaemia 68.99 12.98 25 92015 303 50512781
Bone marrow disorder 67.89 12.98 43 91997 1905 50511179
Bronchitis 67.77 12.98 54 91986 104105 50408979
Computerised tomogram thorax abnormal 67.70 12.98 38 92002 1345 50511739
Lymphopenia 67.35 12.98 110 91930 15511 50497573
Acute lymphocytic leukaemia 67.16 12.98 45 91995 2196 50510888
Refractory anaemia with an excess of blasts 67.15 12.98 26 92014 383 50512701
Abdominal pain upper 66.81 12.98 117 91923 159192 50353892
Osteoarthritis 66.42 12.98 21 92019 68585 50444499
Fibromyalgia 65.77 12.98 4 92036 44974 50468110
Blood cholesterol increased 65.14 12.98 11 92029 55204 50457880
Pneumatosis intestinalis 64.88 12.98 43 91997 2060 50511024
Acquired gene mutation 64.17 12.98 31 92009 800 50512284
Pericardial effusion 64.11 12.98 143 91897 25446 50487638
Gastrointestinal toxicity 63.79 12.98 59 91981 4618 50508466
Bronchopulmonary aspergillosis 62.39 12.98 73 91967 7519 50505565
Drug abuse 62.22 12.98 16 92024 59830 50453254
Loss of personal independence in daily activities 61.75 12.98 25 92015 70025 50443059
Leukaemia 61.52 12.98 51 91989 3448 50509636
Cataract 61.50 12.98 7 92033 47293 50465791
Hypogammaglobulinaemia 61.08 12.98 63 91977 5636 50507448
Injection site swelling 60.23 12.98 4 92036 41769 50471315
Wheezing 60.05 12.98 19 92021 62028 50451056
Ventricular hypokinesia 59.77 12.98 53 91987 3927 50509157
Agranulocytosis 58.56 12.98 124 91916 21297 50491787
Impaired healing 58.19 12.98 27 92013 69759 50443325
Injection site pruritus 57.88 12.98 4 92036 40407 50472677
Metastases to skin 57.06 12.98 34 92006 1349 50511735
Cystitis haemorrhagic 56.99 12.98 50 91990 3652 50509432
Pulmonary toxicity 56.94 12.98 60 91980 5502 50507582
Lower respiratory tract infection 56.31 12.98 54 91986 95147 50417937
Helicobacter infection 56.26 12.98 11 92029 49691 50463393
Varicella zoster virus infection 56.10 12.98 42 91998 2447 50510637
Encephalopathy 55.80 12.98 161 91879 33550 50479534
Lymphadenitis 55.79 12.98 43 91997 2617 50510467
Salivary gland cancer 55.26 12.98 18 92022 154 50512930
Stress 54.75 12.98 15 92025 53778 50459306
Capillary leak syndrome 54.36 12.98 37 92003 1853 50511231
Nephropathy toxic 54.33 12.98 70 91970 7959 50505125
Venoocclusive disease 54.26 12.98 37 92003 1859 50511225
Embolism 53.96 12.98 65 91975 6903 50506181
Intestinal perforation 53.84 12.98 80 91960 10399 50502685
Peripheral motor neuropathy 53.43 12.98 33 92007 1398 50511686
Balance disorder 53.39 12.98 31 92009 70559 50442525
Injection site reaction 52.73 12.98 13 92027 50019 50463065
White blood cell count abnormal 52.72 12.98 57 91983 5383 50507701
Pneumocystis jirovecii infection 51.70 12.98 31 92009 1244 50511840
Injection site bruising 51.63 12.98 4 92036 36764 50476320
Drug interaction 51.50 12.98 188 91852 199433 50313651
Venoocclusive liver disease 50.98 12.98 50 91990 4211 50508873
Inappropriate schedule of product administration 50.93 12.98 34 92006 71797 50441287
Atelectasis 50.22 12.98 106 91934 18164 50494920
Alopecia 50.21 12.98 252 91788 244795 50268289
Extravasation 50.13 12.98 36 92004 1966 50511118
Cerebrovascular accident 50.08 12.98 59 91981 94621 50418463
Suicide attempt 49.78 12.98 16 92024 51716 50461368
Memory impairment 49.32 12.98 43 91997 79317 50433767
Diffuse large B-cell lymphoma 49.14 12.98 56 91984 5606 50507478
Injury 49.12 12.98 14 92026 48911 50464173
Mobility decreased 48.87 12.98 44 91996 79904 50433180
Cardiomyopathy acute 48.64 12.98 17 92023 184 50512900
JC virus infection 48.60 12.98 34 92006 1781 50511303
Heart rate decreased 48.47 12.98 5 92035 36492 50476592
Metastases to pleura 48.46 12.98 30 92010 1276 50511808
Thrombotic microangiopathy 47.90 12.98 69 91971 8722 50504362
Tremor 47.60 12.98 85 91955 114818 50398266
5q minus syndrome 47.44 12.98 17 92023 199 50512885
Recurrent cancer 47.25 12.98 33 92007 1724 50511360
Acute hepatitis B 46.97 12.98 19 92021 316 50512768
Perineal infection 46.72 12.98 15 92025 122 50512962
Klebsiella infection 46.00 12.98 61 91979 7133 50505951
Folliculitis 45.86 12.98 8 92032 39217 50473867
Neutropenic infection 45.57 12.98 27 92013 1060 50512024
Nephrolithiasis 45.44 12.98 5 92035 34688 50478396
Cardiac failure acute 45.31 12.98 65 91975 8185 50504899
Suicidal ideation 45.30 12.98 22 92018 55363 50457721
Lymphoma transformation 45.09 12.98 15 92025 138 50512946
Pulmonary embolism 44.96 12.98 328 91712 101376 50411708
Philadelphia chromosome positive 44.70 12.98 19 92021 360 50512724
Fatigue 44.70 12.98 965 91075 706636 49806448
Blood glucose increased 43.90 12.98 39 92001 71285 50441799
Nasal congestion 43.84 12.98 19 92021 51101 50461983
Perineal necrosis 43.69 12.98 14 92026 113 50512971
Hypersensitivity 43.64 12.98 222 91818 214939 50298145
Cutaneous calcification 42.94 12.98 13 92027 85 50512999
Palpitations 42.77 12.98 66 91974 94440 50418644
Ovarian cancer recurrent 42.54 12.98 24 92016 858 50512226
Plasmacytoma 42.42 12.98 35 92005 2350 50510734
Respiratory syncytial virus infection 41.83 12.98 49 91991 5053 50508031
Alveolar soft part sarcoma 41.82 12.98 13 92027 94 50512990
Clonal evolution 41.25 12.98 12 92028 67 50513017
Metastases to spine 41.12 12.98 37 92003 2794 50510290
Myasthenia gravis crisis 41.01 12.98 18 92022 370 50512714
Gastrosplenic fistula 40.80 12.98 11 92029 44 50513040
Joint stiffness 40.65 12.98 4 92036 30304 50482780
Alveolitis 40.57 12.98 35 92005 2499 50510585
Gastrointestinal fungal infection 40.35 12.98 16 92024 252 50512832
Fluid retention 40.10 12.98 21 92019 50628 50462456
Central nervous system lymphoma 39.92 12.98 27 92013 1338 50511746
Pseudomonal sepsis 39.75 12.98 32 92008 2075 50511009
Enterococcal bacteraemia 39.48 12.98 26 92014 1232 50511852
Organising pneumonia 39.39 12.98 46 91994 4728 50508356
Treatment failure 39.31 12.98 124 91916 137513 50375571
Amnesia 39.04 12.98 14 92026 42246 50470838
Heart rate abnormal 38.99 12.98 42 91998 3950 50509134
Blood lactate dehydrogenase increased 38.94 12.98 100 91940 19462 50493622
Premature baby 38.87 12.98 96 91944 18241 50494843
Hypoxia 38.81 12.98 190 91850 50933 50462151
Migraine 38.65 12.98 48 91992 75232 50437852
Ileus paralytic 38.49 12.98 42 91998 4008 50509076
Secondary immunodeficiency 38.37 12.98 25 92015 1163 50511921
Squamous cell carcinoma of the oral cavity 38.35 12.98 16 92024 289 50512795
Myelopathy 38.25 12.98 34 92006 2527 50510557
Device related infection 38.22 12.98 103 91937 20632 50492452
Clostridium bacteraemia 38.10 12.98 14 92026 177 50512907
Adverse drug reaction 38.00 12.98 27 92013 55195 50457889
Primary cardiac lymphoma 37.95 12.98 9 92031 18 50513066
Gastrooesophageal reflux disease 37.93 12.98 50 91990 76378 50436706
Neck pain 37.85 12.98 29 92011 57038 50456046
Intertrigo 37.80 12.98 17 92023 371 50512713
Cardiogenic shock 37.76 12.98 86 91954 15513 50497571
Colony stimulating factor therapy 37.70 12.98 16 92024 302 50512782
Mucosal toxicity 37.51 12.98 16 92024 306 50512778
Chemotherapy 37.49 12.98 26 92014 1343 50511741
Hypoglycaemia 37.13 12.98 26 92014 53555 50459529
Premature labour 36.81 12.98 71 91969 11405 50501679
Bone lesion 36.44 12.98 46 91994 5124 50507960
T-cell type acute leukaemia 36.15 12.98 10 92030 45 50513039
Invasive ductal breast carcinoma 36.02 12.98 49 91991 5872 50507212
Myocardial infarction 35.85 12.98 67 91973 88960 50424124
Humoral immune defect 35.82 12.98 11 92029 76 50513008
Hypertriglyceridaemia 35.79 12.98 47 91993 5444 50507640
Mantle cell lymphoma recurrent 35.73 12.98 12 92028 114 50512970
Cardiac failure chronic 35.70 12.98 38 92002 3525 50509559
Visual impairment 35.61 12.98 43 91997 68232 50444852
Amniotic fluid index decreased 35.59 12.98 8 92032 11 50513073
Incorrect dose administered 35.57 12.98 22 92018 48392 50464692
Acute myelomonocytic leukaemia 35.33 12.98 13 92027 165 50512919
Hepatitis E 35.21 12.98 24 92016 1205 50511879
Ovarian epithelial cancer recurrent 35.18 12.98 8 92032 12 50513072
Flagellate dermatitis 35.12 12.98 13 92027 168 50512916
Mesenteric abscess 35.09 12.98 11 92029 82 50513002
Lung infiltration 34.85 12.98 76 91964 13317 50499767
Toxic cardiomyopathy 34.83 12.98 12 92028 124 50512960
Blast cells present 34.80 12.98 16 92024 368 50512716
Unintentional medical device removal 34.62 12.98 46 91994 5389 50507695
Enterococcal sepsis 34.41 12.98 24 92016 1251 50511833
Escherichia bacteraemia 34.39 12.98 35 92005 3081 50510003
Plasma cell leukaemia 34.36 12.98 22 92018 993 50512091
Osteomyelitis bacterial 34.05 12.98 13 92027 184 50512900
Haemoglobin abnormal 33.90 12.98 41 91999 4371 50508713
Body dysmorphic disorder 33.65 12.98 14 92026 251 50512833
Ill-defined disorder 33.49 12.98 30 92010 54624 50458460
Loss of consciousness 33.45 12.98 89 91951 104264 50408820
Limb discomfort 33.23 12.98 3 92037 24354 50488730
Musculoskeletal pain 33.05 12.98 50 91990 72127 50440957
Necrotising gastritis 32.95 12.98 10 92030 66 50513018
Hydrothorax 32.86 12.98 19 92021 712 50512372
Large intestinal ulcer perforation 32.82 12.98 10 92030 67 50513017
Metastases to meninges 32.76 12.98 28 92012 1974 50511110
Rhabdomyolysis 32.68 12.98 15 92025 39012 50474072
Localised infection 32.56 12.98 4 92036 25481 50487603
Exposure during pregnancy 32.54 12.98 350 91690 120665 50392419
Infection reactivation 32.45 12.98 21 92019 966 50512118
Mitral valve incompetence 32.42 12.98 87 91953 17384 50495700
Unevaluable event 32.39 12.98 22 92018 46044 50467040
Pyomyositis 32.20 12.98 15 92025 356 50512728
Hepatic failure 32.07 12.98 130 91910 32153 50480931
Colitis 32.01 12.98 147 91893 38382 50474702
Therapeutic response delayed 31.84 12.98 17 92023 544 50512540
Traumatic lung injury 31.77 12.98 24 92016 1417 50511667
Epstein-Barr virus associated lymphoma 31.76 12.98 16 92024 453 50512631
Leukoerythroblastosis 31.66 12.98 13 92027 225 50512859
Amenorrhoea 31.62 12.98 56 91984 8428 50504656
Bicytopenia 31.52 12.98 27 92013 1909 50511175
Pneumonia fungal 31.35 12.98 39 92001 4281 50508803
Respiratory arrest 31.23 12.98 8 92032 30001 50483083
Heart rate increased 31.22 12.98 58 91982 77192 50435892
Blood pressure fluctuation 31.22 12.98 13 92027 35810 50477274
Nail pigmentation 31.04 12.98 12 92028 176 50512908
Illness 30.99 12.98 4 92036 24536 50488548
Vision blurred 30.95 12.98 60 91980 78587 50434497
Hepatic infarction 30.88 12.98 17 92023 579 50512505
Irritability 30.72 12.98 7 92033 28419 50484665
Influenza 30.53 12.98 74 91966 89464 50423620
Cardiac dysfunction 30.33 12.98 25 92015 1676 50511408
Urinary tract infection 30.32 12.98 261 91779 223759 50289325
Cytomegalovirus viraemia 30.22 12.98 40 92000 4669 50508415
Radiation necrosis 30.18 12.98 14 92026 329 50512755
Nasal abscess 30.16 12.98 11 92029 136 50512948
Hypertransaminasaemia 30.13 12.98 35 92005 3576 50509508
Nodular regenerative hyperplasia 29.99 12.98 13 92027 259 50512825
C-reactive protein abnormal 29.75 12.98 7 92033 27802 50485282
Malignant transformation 29.68 12.98 14 92026 342 50512742
Carbohydrate antigen 125 increased 29.61 12.98 29 92011 2438 50510646
Angioedema 29.27 12.98 16 92024 37660 50475424
Emotional distress 29.15 12.98 8 92032 28655 50484429
Blood pressure systolic increased 29.11 12.98 14 92026 35435 50477649
Chronic myeloid leukaemia 29.02 12.98 27 92013 2129 50510955
Hepatotoxicity 28.95 12.98 112 91928 27114 50485970
Gastric disorder 28.67 12.98 9 92031 29539 50483545
Thyroid dermatopathy 28.59 12.98 7 92033 17 50513067
Vena cava thrombosis 28.54 12.98 26 92014 1995 50511089
Periorbital cellulitis 28.54 12.98 16 92024 565 50512519
Acute leukaemia 28.38 12.98 20 92020 1060 50512024
Cytogenetic abnormality 28.27 12.98 15 92025 474 50512610
Chest pain 28.18 12.98 197 91843 176685 50336399
Clostridium difficile infection 28.16 12.98 106 91934 25333 50487751
Blister 28.02 12.98 72 91968 85346 50427738
Quadriplegia 28.00 12.98 24 92016 1699 50511385
Ototoxicity 27.61 12.98 20 92020 1107 50511977
Agitation 27.44 12.98 34 92006 53350 50459734
Swollen tongue 27.28 12.98 9 92031 28621 50484463
T-cell lymphoma 27.24 12.98 16 92024 618 50512466
Left ventricular dilatation 27.23 12.98 14 92026 414 50512670
Leukaemic lymphoma 27.23 12.98 9 92031 81 50513003
Product quality issue 27.21 12.98 11 92029 30847 50482237
Bursitis 27.03 12.98 4 92036 22131 50490953
Systolic dysfunction 27.02 12.98 22 92018 1450 50511634
Hepatocellular injury 26.99 12.98 106 91934 25841 50487243
B-cell lymphoma refractory 26.84 12.98 9 92031 85 50512999
Intussusception 26.84 12.98 14 92026 427 50512657
Clonal haematopoiesis 26.80 12.98 6 92034 8 50513076
Infusion site streaking 26.75 12.98 14 92026 430 50512654
Cerebral venous sinus thrombosis 26.63 12.98 23 92017 1645 50511439
Tissue infiltration 26.54 12.98 15 92025 538 50512546
Enterococcal infection 26.32 12.98 46 91994 6852 50506232
Limb injury 26.31 12.98 3 92037 20247 50492837
Vocal cord paralysis 26.24 12.98 23 92017 1678 50511406
Hyperpyrexia 26.20 12.98 30 92010 3019 50510065
Platelet count abnormal 26.13 12.98 29 92011 2820 50510264
Metastases to the mediastinum 26.00 12.98 14 92026 456 50512628
Computerised tomogram thorax 25.97 12.98 10 92030 145 50512939
Cerebellar stroke 25.90 12.98 11 92029 208 50512876
Blood lactate dehydrogenase abnormal 25.90 12.98 11 92029 208 50512876
Hallucination 25.83 12.98 28 92012 46629 50466455
Clostridium difficile colitis 25.83 12.98 81 91959 17661 50495423
Toxic neuropathy 25.77 12.98 13 92027 369 50512715
Invasive breast carcinoma 25.76 12.98 15 92025 570 50512514
Metastases to soft tissue 25.66 12.98 10 92030 150 50512934
Pulmonary alveolar haemorrhage 25.52 12.98 34 92006 3993 50509091
Listeria sepsis 25.29 12.98 15 92025 590 50512494
Acne 25.22 12.98 3 92037 19592 50493492
Hyperhidrosis 25.22 12.98 81 91959 89345 50423739
Flatulence 25.17 12.98 11 92029 29447 50483637
Rash pruritic 25.09 12.98 30 92010 47816 50465268
Radiation skin injury 25.07 12.98 17 92023 846 50512238
Basal ganglion degeneration 24.97 12.98 13 92027 395 50512689
Leukoencephalopathy 24.94 12.98 33 92007 3850 50509234
Granulomatous liver disease 24.90 12.98 16 92024 727 50512357
Ventricular internal diameter abnormal 24.87 12.98 7 92033 34 50513050
Cytokine release syndrome 24.79 12.98 51 91989 8583 50504501
Osteoporosis 24.77 12.98 27 92013 44852 50468232
Type 2 diabetes mellitus 24.73 12.98 16 92024 34359 50478725
General physical health deterioration 24.72 12.98 380 91660 142054 50371030
Onycholysis 24.70 12.98 20 92020 1308 50511776
Dry mouth 24.68 12.98 40 92000 56138 50456946
Peripheral T-cell lymphoma unspecified 24.68 12.98 10 92030 167 50512917
Treatment noncompliance 24.61 12.98 12 92028 30138 50482946
Road traffic accident 24.39 12.98 7 92033 24345 50488739
Pulse waveform abnormal 24.20 12.98 8 92032 72 50513012
Ankle brachial index decreased 24.10 12.98 8 92032 73 50513011
Abdominal compartment syndrome 24.04 12.98 14 92026 532 50512552
Coronary artery disease 24.01 12.98 12 92028 29714 50483370
International normalised ratio increased 23.77 12.98 26 92014 43126 50469958
Carotid intima-media thickness increased 23.73 12.98 8 92032 77 50513007
Bacterial sepsis 23.67 12.98 31 92009 3581 50509503
Hyperferritinaemia 23.60 12.98 9 92031 127 50512957
Left atrial enlargement 23.58 12.98 11 92029 262 50512822
Mediastinitis 23.55 12.98 10 92030 189 50512895
Chronic obstructive pulmonary disease 23.52 12.98 38 92002 53397 50459687
Primary immunodeficiency syndrome 23.50 12.98 7 92033 43 50513041
Joint range of motion decreased 23.42 12.98 3 92037 18509 50494575
Osteolysis 23.40 12.98 26 92014 2531 50510553
Myeloproliferative neoplasm 23.34 12.98 13 92027 453 50512631
Ear infection 23.32 12.98 9 92031 25961 50487123
Klebsiella bacteraemia 23.26 12.98 19 92021 1258 50511826
Aggression 23.22 12.98 5 92035 21111 50491973
Abortion spontaneous 23.20 12.98 25 92015 41747 50471337
Increased liver stiffness 23.10 12.98 5 92035 5 50513079
Cardio-respiratory arrest 23.10 12.98 39 92001 53853 50459231
Deep vein thrombosis 23.05 12.98 219 91821 73085 50439999
Metastases to chest wall 23.03 12.98 13 92027 465 50512619
Fanconi syndrome 23.03 12.98 18 92022 1118 50511966
Dry eye 23.00 12.98 15 92025 32080 50481004
Abnormal behaviour 23.00 12.98 4 92036 19654 50493430
Disseminated intravascular coagulation 22.93 12.98 76 91964 17059 50496025
Refractory cytopenia with multilineage dysplasia 22.86 12.98 9 92031 139 50512945
Cardiac ventricular thrombosis 22.83 12.98 13 92027 473 50512611
Depressed level of consciousness 22.82 12.98 37 92003 51916 50461168
Rhinovirus infection 22.65 12.98 30 92010 3504 50509580
Swelling face 22.60 12.98 38 92002 52557 50460527
Proteinuria 22.55 12.98 74 91966 16523 50496561
Heart rate irregular 22.52 12.98 4 92036 19356 50493728
Large intestine perforation 22.38 12.98 45 91995 7449 50505635
Sleep disorder 22.28 12.98 44 91996 57239 50455845
Pseudocirrhosis 22.19 12.98 14 92026 616 50512468
Drug reaction with eosinophilia and systemic symptoms 22.18 12.98 12 92028 28412 50484672
Blood magnesium decreased 22.16 12.98 57 91983 11103 50501981
Hypoaesthesia 22.14 12.98 138 91902 127119 50385965
Acute biphenotypic leukaemia 22.12 12.98 7 92033 54 50513030
Crying 22.11 12.98 5 92035 20411 50492673
Joint ankylosis 22.08 12.98 15 92025 749 50512335
Candida infection 22.01 12.98 93 91947 23430 50489654
Sinus polyp 21.98 12.98 11 92029 307 50512777
Anastomotic leak 21.92 12.98 12 92028 404 50512680
Gait inability 21.89 12.98 21 92019 37006 50476078
Uterine enlargement 21.85 12.98 17 92023 1049 50512035
Metastases to pancreas 21.79 12.98 10 92030 229 50512855
Aspergillus infection 21.63 12.98 42 91998 6779 50506305
Non-cirrhotic portal hypertension 21.55 12.98 9 92031 163 50512921
Diabetes mellitus 21.46 12.98 35 92005 48998 50464086
Subdural hygroma 21.44 12.98 10 92030 238 50512846
Combined immunodeficiency 21.43 12.98 8 92032 106 50512978
BRCA2 gene mutation 21.28 12.98 7 92033 62 50513022
Mantle cell lymphoma 21.14 12.98 12 92028 434 50512650
Basal cell carcinoma 21.13 12.98 8 92032 23348 50489736
Nervousness 21.10 12.98 12 92028 27639 50485445
Amputation stump pain 21.01 12.98 6 92034 31 50513053
Dysplasia 21.01 12.98 14 92026 677 50512407
Gastric stenosis 20.89 12.98 7 92033 66 50513018
Acute monocytic leukaemia 20.89 12.98 7 92033 66 50513018
Hip arthroplasty 20.77 12.98 15 92025 30414 50482670
Drug clearance decreased 20.73 12.98 17 92023 1132 50511952
Colitis ulcerative 20.69 12.98 3 92037 16851 50496233
Paraparesis 20.66 12.98 22 92018 2042 50511042
Mucormycosis 20.61 12.98 24 92016 2459 50510625
Bone marrow infiltration 20.60 12.98 12 92028 456 50512628
Restlessness 20.58 12.98 10 92030 25163 50487921
Geotrichum infection 20.56 12.98 12 92028 458 50512626
Epstein-Barr virus associated lymphoproliferative disorder 20.54 12.98 20 92020 1669 50511415
Acute hepatic failure 20.50 12.98 69 91971 15608 50497476
Opsoclonus myoclonus 20.47 12.98 8 92032 121 50512963
Administration site extravasation 20.46 12.98 14 92026 707 50512377
Brain oedema 20.39 12.98 59 91981 12311 50500773
Cerebellar haemangioma 20.35 12.98 7 92033 72 50513012
Vulvovaginal inflammation 20.26 12.98 13 92027 589 50512495
Tumour necrosis 20.24 12.98 14 92026 720 50512364
Pharyngeal inflammation 20.07 12.98 13 92027 599 50512485
Blood pressure decreased 20.02 12.98 45 91995 55864 50457220
Liver function test abnormal 20.02 12.98 31 92009 44308 50468776
Toxic erythema of chemotherapy 20.00 12.98 8 92032 129 50512955
Mucoepidermoid carcinoma 19.98 12.98 6 92034 38 50513046
Duodenal stenosis 19.96 12.98 12 92028 484 50512600
Lip swelling 19.96 12.98 10 92030 24726 50488358
Sciatica 19.89 12.98 7 92033 21375 50491709
Dysaesthesia 19.89 12.98 29 92011 3706 50509378
Therapy interrupted 19.80 12.98 6 92034 20146 50492938
Eye swelling 19.79 12.98 6 92034 20138 50492946
Pulmonary vein stenosis 19.77 12.98 7 92033 79 50513005
Abdominal abscess 19.74 12.98 30 92010 3978 50509106
Respiratory distress 19.46 12.98 108 91932 30381 50482703
Eye pain 19.45 12.98 14 92026 28435 50484649
Red blood cell sedimentation rate increased 19.44 12.98 15 92025 29401 50483683
Acute respiratory distress syndrome 19.42 12.98 83 91957 21016 50492068
Jejunal stenosis 19.35 12.98 6 92034 43 50513041
Transaminases 19.30 12.98 7 92033 85 50512999
Dementia 19.28 12.98 3 92037 15994 50497090
Mood swings 19.21 12.98 3 92037 15951 50497133
Ovarian cancer 19.21 12.98 34 92006 5115 50507969
Prescribed underdose 19.21 12.98 3 92037 15946 50497138
Influenza like illness 19.18 12.98 48 91992 57411 50455673
Vulvovaginitis 19.17 12.98 10 92030 305 50512779
Weight decreased 19.16 12.98 285 91755 220960 50292124
Leukaemia cutis 19.08 12.98 7 92033 88 50512996
PIK3CA-activated mutation 19.00 12.98 14 92026 796 50512288
Pleuroparenchymal fibroelastosis 18.96 12.98 5 92035 18 50513066
Small intestinal perforation 18.92 12.98 17 92023 1281 50511803
Mitral valve disease 18.90 12.98 21 92019 2045 50511039
Peritonitis viral 18.77 12.98 6 92034 48 50513036
Breast neoplasm 18.76 12.98 17 92023 1296 50511788
Atypical haemolytic uraemic syndrome 18.68 12.98 12 92028 545 50512539
Cytomegalovirus chorioretinitis 18.62 12.98 18 92022 1489 50511595
Subileus 18.58 12.98 24 92016 2735 50510349
Panic attack 18.57 12.98 6 92034 19336 50493748
Chronic hepatitis 18.54 12.98 14 92026 826 50512258
Human rhinovirus test positive 18.52 12.98 8 92032 158 50512926
Neonatal lupus erythematosus 18.48 12.98 4 92036 4 50513080
Serotonin syndrome 18.47 12.98 11 92029 24702 50488382
Intervertebral disc protrusion 18.42 12.98 7 92033 20386 50492698
Bradycardia 18.41 12.98 58 91982 64368 50448716
Staphylococcal sepsis 18.39 12.98 40 92000 6996 50506088
Osteosarcoma metastatic 18.35 12.98 5 92035 21 50513063
Paranasal sinus mucosal hypertrophy 18.35 12.98 5 92035 21 50513063
Malignant ascites 18.35 12.98 14 92026 839 50512245
Gallbladder disorder 18.34 12.98 4 92036 16738 50496346
Liver function test increased 18.31 12.98 12 92028 25594 50487490
Tendonitis 18.28 12.98 4 92036 16701 50496383
Atrial fibrillation 18.25 12.98 273 91767 101472 50411612
Enterocutaneous fistula 18.24 12.98 16 92024 1168 50511916
Diarrhoea haemorrhagic 18.23 12.98 42 91998 7633 50505451
Renal disorder 18.20 12.98 14 92026 27491 50485593
Fungal oesophagitis 18.20 12.98 12 92028 570 50512514
Central nervous system enteroviral infection 18.17 12.98 5 92035 22 50513062
Liver abscess 18.16 12.98 23 92017 2570 50510514
Infection 18.12 12.98 427 91613 172527 50340557
Triple negative breast cancer 18.09 12.98 7 92033 103 50512981
Femur fracture 18.08 12.98 25 92015 37439 50475645
Dysstasia 18.07 12.98 5 92035 17814 50495270
Secondary cerebellar degeneration 17.96 12.98 6 92034 56 50513028
Enterocolitis 17.93 12.98 38 92002 6529 50506555
Anaesthesia 17.92 12.98 10 92030 350 50512734
Inflammation 17.88 12.98 49 91991 56863 50456221
Tooth disorder 17.81 12.98 11 92029 24217 50488867
Urethritis 17.67 12.98 9 92031 261 50512823
Inflammatory myofibroblastic tumour 17.64 12.98 5 92035 25 50513059
Product prescribing error 17.64 12.98 8 92032 20953 50492131
Hormone receptor positive breast cancer 17.62 12.98 11 92029 475 50512609
Therapy cessation 17.52 12.98 13 92027 25998 50487086
Head injury 17.52 12.98 11 92029 24009 50489075
Acute pulmonary oedema 17.52 12.98 40 92000 7227 50505857
Drug dependence 17.49 12.98 7 92033 19752 50493332
Injection site rash 17.44 12.98 4 92036 16173 50496911
Hip fracture 17.42 12.98 13 92027 25918 50487166
Lactic acidosis 17.40 12.98 21 92019 33334 50479750
Pneumonia 17.40 12.98 848 91192 377553 50135531
Oesophageal candidiasis 17.38 12.98 32 92008 4962 50508122
Synovial sarcoma 17.33 12.98 5 92035 27 50513057
Artificial menopause 17.33 12.98 5 92035 27 50513057
Nightmare 17.30 12.98 4 92036 16082 50497002
Trichodysplasia spinulosa 17.29 12.98 11 92029 491 50512593
Rhinorrhoea 17.29 12.98 43 91997 51540 50461544
Vomiting 17.28 12.98 1013 91027 459745 50053339
Sarcoidosis 17.28 12.98 32 92008 4985 50508099
Oral fungal infection 17.27 12.98 22 92018 2473 50510611
Primary mediastinal large B-cell lymphoma recurrent 17.25 12.98 6 92034 64 50513020
Sinus disorder 17.24 12.98 6 92034 18452 50494632
Cardiac tamponade 17.17 12.98 29 92011 4203 50508881
Accidental overdose 17.16 12.98 7 92033 19526 50493558
Pneumonia influenzal 17.15 12.98 17 92023 1450 50511634
Seasonal allergy 17.14 12.98 3 92037 14673 50498411
Hyperbilirubinaemia 17.10 12.98 47 91993 9523 50503561
Abdominal neoplasm 17.09 12.98 9 92031 280 50512804
Stem cell transplant 17.09 12.98 18 92022 1650 50511434
Eye irritation 17.03 12.98 5 92035 17135 50495949
Myasthenic syndrome 17.01 12.98 8 92032 194 50512890
Device dislocation 16.95 12.98 9 92031 21537 50491547
Herpes zoster meningoencephalitis 16.94 12.98 9 92031 285 50512799
Mediastinum neoplasm 16.92 12.98 6 92034 68 50513016
Rectal fissure 16.82 12.98 11 92029 515 50512569
Disorientation 16.81 12.98 24 92016 35460 50477624
Orthopnoea 16.80 12.98 34 92006 5655 50507429
Glaucoma 16.67 12.98 4 92036 15682 50497402
Atrial flutter 16.62 12.98 44 91996 8719 50504365
Metastases to abdominal cavity 16.55 12.98 10 92030 407 50512677
Ventricular remodelling 16.55 12.98 4 92036 9 50513075
Failure to thrive 16.45 12.98 36 92004 6322 50506762
Heavy menstrual bleeding 16.44 12.98 4 92036 15533 50497551
Pleural disorder 16.41 12.98 11 92029 537 50512547
Venous thrombosis limb 16.41 12.98 22 92018 2600 50510484
Toxic encephalopathy 16.33 12.98 33 92007 5482 50507602
Granulocytopenia 16.33 12.98 32 92008 5199 50507885
Poor quality sleep 16.28 12.98 5 92035 16641 50496443
Febrile infection 16.27 12.98 15 92025 1169 50511915
BK virus infection 16.26 12.98 23 92017 2858 50510226
Granulomatous pneumonitis 16.22 12.98 5 92035 35 50513049
Jejunal ulcer perforation 16.22 12.98 5 92035 35 50513049
Enterovirus test positive 16.22 12.98 7 92033 138 50512946
Lung disorder 16.21 12.98 138 91902 44661 50468423
Portal hypertension 16.15 12.98 25 92015 3367 50509717
Haematoma 16.14 12.98 19 92021 30491 50482593
VIth nerve paresis 16.11 12.98 6 92034 79 50513005
Renal tubular disorder 16.10 12.98 21 92019 2416 50510668
Pregnancy 16.10 12.98 18 92022 29559 50483525
Antithrombin III decreased 16.09 12.98 8 92032 220 50512864
Transient ischaemic attack 16.05 12.98 21 92019 32189 50480895
Acute hepatitis C 16.04 12.98 6 92034 80 50513004
Low birth weight baby 16.02 12.98 34 92006 5847 50507237
Kidney infection 16.02 12.98 7 92033 18739 50494345
Movement disorder 16.02 12.98 6 92034 17626 50495458
Aplastic anaemia 15.98 12.98 40 92000 7663 50505421
Fungaemia 15.96 12.98 19 92021 1993 50511091
Lethargy 15.95 12.98 42 91998 49390 50463694
Mucoepidermoid carcinoma of salivary gland 15.93 12.98 3 92037 0 50513084
Maternal exposure during pregnancy 15.92 12.98 200 91840 159578 50353506
Intestinal obstruction 15.88 12.98 92 91948 26291 50486793
Meningitis streptococcal 15.81 12.98 7 92033 147 50512937
Syphilis 15.81 12.98 7 92033 147 50512937
Cholelithiasis 15.79 12.98 28 92012 37945 50475139
Leukoplakia oral 15.72 12.98 7 92033 149 50512935
Cytology abnormal 15.72 12.98 4 92036 12 50513072
Thrombophlebitis 15.72 12.98 27 92013 3966 50509118
Salmonella sepsis 15.70 12.98 8 92032 232 50512852
Neurological decompensation 15.69 12.98 20 92020 2250 50510834
Dermatitis bullous 15.68 12.98 38 92002 7135 50505949
Pleural neoplasm 15.67 12.98 8 92032 233 50512851
Pyloric stenosis 15.65 12.98 9 92031 334 50512750
Blood stem cell transplant failure 15.64 12.98 7 92033 151 50512933
Metastases to retroperitoneum 15.51 12.98 7 92033 154 50512930
Faeces discoloured 15.48 12.98 5 92035 16119 50496965
Acral peeling skin syndrome 15.48 12.98 4 92036 13 50513071
Metastases to ovary 15.48 12.98 9 92031 341 50512743
Hypersensitivity pneumonitis 15.33 12.98 20 92020 2302 50510782
Pulmonary artery stenosis 15.27 12.98 7 92033 160 50512924
Oedema peripheral 15.27 12.98 199 91841 157762 50355322
Pulmonary mass 15.26 12.98 71 91969 18634 50494450
Vessel puncture site bruise 15.22 12.98 9 92031 352 50512732
Tumour marker increased 15.16 12.98 26 92014 3814 50509270
Depressed mood 15.16 12.98 24 92016 33999 50479085
Rash erythematous 15.14 12.98 25 92015 34827 50478257
Laboratory test abnormal 15.12 12.98 12 92028 23196 50489888
Sputum discoloured 15.08 12.98 3 92037 13392 50499692
Listeria encephalitis 14.99 12.98 8 92032 256 50512828
Acute erythroid leukaemia 14.93 12.98 5 92035 47 50513037
Haemorrhage intracranial 14.91 12.98 53 91987 12321 50500763
Carbohydrate antigen 15-3 increased 14.90 12.98 14 92026 1118 50511966
Pulmonary haemorrhage 14.84 12.98 35 92005 6457 50506627
Beta 2 microglobulin decreased 14.84 12.98 4 92036 16 50513068
Necrosis 14.82 12.98 29 92011 4707 50508377
Venous thrombosis 14.78 12.98 28 92012 4438 50508646
Throat irritation 14.77 12.98 20 92020 30219 50482865
Rhabdomyosarcoma 14.77 12.98 6 92034 101 50512983
IIIrd nerve paralysis 14.76 12.98 11 92029 636 50512448
Blood potassium decreased 14.69 12.98 28 92012 36917 50476167
Diabetes mellitus inadequate control 14.68 12.98 3 92037 13142 50499942
Medication error 14.68 12.98 27 92013 36077 50477007
Cerebral haemangioma 14.66 12.98 6 92034 103 50512981
Metastases to vagina 14.64 12.98 4 92036 17 50513067
Necrotising colitis 14.62 12.98 10 92030 505 50512579
Pseudomonas infection 14.61 12.98 44 91996 9386 50503698
Hypoglossal nerve paresis 14.50 12.98 6 92034 106 50512978
Joint effusion 14.49 12.98 3 92037 13018 50500066
B-lymphocyte count abnormal 14.48 12.98 5 92035 52 50513032
Epstein Barr virus positive mucocutaneous ulcer 14.47 12.98 9 92031 386 50512698
Eczema 14.47 12.98 12 92028 22690 50490394
Right ventricular dysfunction 14.45 12.98 16 92024 1552 50511532
Chronic hepatitis B 14.44 12.98 7 92033 182 50512902
Alopecia areata 14.44 12.98 15 92025 1353 50511731
Retroperitoneal mass 14.40 12.98 6 92034 108 50512976
Respiratory tract congestion 14.37 12.98 4 92036 14195 50498889
Hepatic lesion 14.35 12.98 26 92014 3982 50509102
Skin mass 14.35 12.98 30 92010 5105 50507979
Tachycardia induced cardiomyopathy 14.32 12.98 5 92035 54 50513030
Ocular lymphoma 14.32 12.98 5 92035 54 50513030
Photosensitivity reaction 14.31 12.98 3 92037 12908 50500176
Metastases to stomach 14.30 12.98 7 92033 186 50512898
Subclavian vein thrombosis 14.29 12.98 17 92023 1782 50511302
Metastatic neoplasm 14.28 12.98 25 92015 3729 50509355
Diverticulitis 14.23 12.98 24 92016 33158 50479926
Hypokalaemia 14.21 12.98 232 91808 87760 50425324
Encephalitis viral 14.21 12.98 16 92024 1581 50511503
Sneezing 14.13 12.98 4 92036 14040 50499044
Malignant neoplasm of orbit 14.12 12.98 4 92036 20 50513064
Lymphadenopathy mediastinal 14.11 12.98 20 92020 2491 50510593
Dermatitis allergic 14.01 12.98 3 92037 12717 50500367
Chronic myelomonocytic leukaemia 13.95 12.98 8 92032 295 50512789
Vascular compression 13.91 12.98 6 92034 118 50512966
Orthostatic hypotension 13.90 12.98 20 92020 29461 50483623
Obliterative bronchiolitis 13.88 12.98 17 92023 1836 50511248
Chondrosarcoma metastatic 13.86 12.98 3 92037 3 50513081
Lung adenocarcinoma 13.78 12.98 26 92014 4108 50508976
Thrombocytopenic purpura 13.76 12.98 14 92026 1232 50511852
Leukaemia recurrent 13.69 12.98 14 92026 1240 50511844
Feeling hot 13.67 12.98 32 92008 39170 50473914
Hepatic calcification 13.65 12.98 4 92036 23 50513061
Peripheral sensorimotor neuropathy 13.61 12.98 14 92026 1248 50511836
Adverse event 13.51 12.98 38 92002 43725 50469359
Hepatitis C RNA increased 13.51 12.98 6 92034 127 50512957
Restless legs syndrome 13.48 12.98 6 92034 15891 50497193
Upper limb fracture 13.45 12.98 6 92034 15867 50497217
Peritoneal disorder 13.43 12.98 9 92031 439 50512645
Lymphoproliferative disorder 13.42 12.98 21 92019 2856 50510228
Mucosal erosion 13.38 12.98 14 92026 1273 50511811
Hydronephrosis 13.37 12.98 40 92000 8501 50504583
Mediastinal fibrosis 13.37 12.98 4 92036 25 50513059
Lymph node pain 13.31 12.98 14 92026 1281 50511803
Coronary ostial stenosis 13.28 12.98 5 92035 68 50513016
Pneumonia cytomegaloviral 13.25 12.98 17 92023 1924 50511160
Hyperkalaemia 13.24 12.98 44 91996 48045 50465039
Corneal graft rejection 13.23 12.98 4 92036 26 50513058
Spinal cord compression 13.21 12.98 24 92016 3685 50509399
Sinus tachycardia 13.20 12.98 75 91965 21279 50491805
Chemotherapeutic drug level increased 13.17 12.98 6 92034 135 50512949
Cyst 13.17 12.98 3 92037 12184 50500900
Paronychia 13.15 12.98 27 92013 4537 50508547
Tachypnoea 13.15 12.98 57 91983 14520 50498564
Bladder perforation 13.13 12.98 6 92034 136 50512948
Rectal haemorrhage 13.03 12.98 32 92008 38526 50474558
Ventricular asystole 13.02 12.98 5 92035 72 50513012
Postictal state 12.99 12.98 12 92028 938 50512146

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 3347.88 13.36 2480 67928 109760 29394359
Neutropenia 1146.26 13.36 1484 68924 130227 29373892
Product use in unapproved indication 935.73 13.36 1091 69317 85784 29418335
Off label use 815.86 13.36 2032 68376 298768 29205351
Diffuse large B-cell lymphoma recurrent 590.25 13.36 225 70183 2372 29501747
Mucosal inflammation 585.43 13.36 532 69876 31063 29473056
Hepatitis B 554.75 13.36 268 70140 5229 29498890
Second primary malignancy 552.92 13.36 285 70123 6420 29497699
Haematotoxicity 530.18 13.36 277 70131 6422 29497697
Cardiotoxicity 486.91 13.36 234 70174 4510 29499609
Myelosuppression 467.26 13.36 316 70092 11911 29492208
Myelodysplastic syndrome 462.03 13.36 364 70044 17430 29486689
Acute myeloid leukaemia 437.80 13.36 342 70066 16171 29487948
Hepatitis B reactivation 417.73 13.36 187 70221 3042 29501077
Bone marrow failure 403.62 13.36 407 70001 27042 29477077
Disease progression 397.88 13.36 705 69703 81211 29422908
Tumour lysis syndrome 334.75 13.36 272 70136 13612 29490507
Pancytopenia 297.37 13.36 629 69779 82539 29421580
Thrombocytopenia 291.99 13.36 841 69567 133982 29370137
Febrile bone marrow aplasia 264.24 13.36 183 70225 7168 29496951
Pneumocystis jirovecii pneumonia 245.08 13.36 248 70160 16531 29487588
Neutropenic sepsis 233.85 13.36 206 70202 11521 29492598
Leukopenia 232.33 13.36 447 69961 54756 29449363
Neutrophil count decreased 228.19 13.36 388 70020 43179 29460940
Progressive multifocal leukoencephalopathy 221.14 13.36 176 70232 8543 29495576
Cytomegalovirus chorioretinitis 217.22 13.36 120 70288 3118 29501001
Acquired gene mutation 215.91 13.36 89 70319 1169 29502950
Diffuse large B-cell lymphoma refractory 209.91 13.36 80 70328 842 29503277
Therapy partial responder 209.68 13.36 139 70269 5060 29499059
Cytopenia 198.20 13.36 174 70234 9685 29494434
Fall 195.12 13.36 89 70319 177089 29327030
Product dose omission issue 185.38 13.36 11 70397 96372 29407747
Neoplasm progression 183.52 13.36 224 70184 18388 29485731
Pyrexia 173.19 13.36 1223 69185 286399 29217720
Septic shock 161.78 13.36 417 69991 62143 29441976
Posterior reversible encephalopathy syndrome 159.90 13.36 148 70260 8828 29495291
Mantle cell lymphoma recurrent 157.25 13.36 55 70353 443 29503676
B-cell lymphoma recurrent 152.49 13.36 57 70351 566 29503553
Cardiomyopathy 137.78 13.36 173 70235 14614 29489505
Rash 132.75 13.36 154 70254 189665 29314454
Malignant neoplasm progression 132.62 13.36 432 69976 73427 29430692
Neuropathy peripheral 131.66 13.36 420 69988 70607 29433512
Dizziness 131.46 13.36 155 70253 189529 29314590
Sepsis 129.01 13.36 675 69733 142007 29362112
Myocardial infarction 128.33 13.36 51 70357 110245 29393874
Arthralgia 123.92 13.36 91 70317 139526 29364593
Polyneuropathy 122.62 13.36 148 70260 12004 29492115
Lymphadenopathy 120.52 13.36 215 70193 24834 29479285
Anxiety 117.98 13.36 29 70379 85336 29418783
Ejection fraction decreased 110.88 13.36 162 70246 15816 29488303
Diffuse large B-cell lymphoma 110.85 13.36 103 70305 6173 29497946
Cytomegalovirus infection 110.08 13.36 198 70210 23017 29481102
Pain 103.52 13.36 155 70253 171277 29332842
Rhabdomyolysis 100.56 13.36 13 70395 60795 29443324
Muscle spasms 100.51 13.36 17 70391 65065 29439054
Death 100.22 13.36 447 69961 341637 29162482
Disease recurrence 98.55 13.36 153 70255 15761 29488358
Hypogammaglobulinaemia 96.79 13.36 93 70315 5814 29498305
Drug interaction 96.20 13.36 204 70204 197181 29306938
Herpes simplex 95.67 13.36 85 70323 4805 29499314
Neoplasm recurrence 94.91 13.36 59 70349 1918 29502201
White blood cell count decreased 92.92 13.36 419 69989 82943 29421176
Pruritus 92.67 13.36 85 70323 116764 29387355
Sweat gland tumour 91.10 13.36 35 70373 377 29503742
Anaemia 90.47 13.36 800 69608 200151 29303968
Somnolence 90.33 13.36 56 70352 93899 29410220
Weight increased 89.87 13.36 35 70373 76632 29427487
Blood pressure increased 89.35 13.36 32 70376 73771 29430348
Lymphopenia 89.28 13.36 134 70274 13399 29490720
Joint swelling 88.70 13.36 8 70400 49622 29454497
Myalgia 88.08 13.36 33 70375 73986 29430133
Drug resistance 87.54 13.36 172 70236 21368 29482751
Peripheral swelling 87.38 13.36 22 70386 63717 29440402
Feeling abnormal 86.82 13.36 13 70395 54432 29449687
Fatigue 86.23 13.36 425 69983 316396 29187723
Hepatic failure 85.48 13.36 214 70194 31298 29472821
Insomnia 85.19 13.36 53 70355 88708 29415411
Headache 84.61 13.36 180 70228 173827 29330292
Overdose 83.28 13.36 43 70365 79776 29424343
Depression 81.50 13.36 51 70357 85096 29419023
Tremor 80.70 13.36 37 70371 73501 29430618
Venoocclusive liver disease 79.37 13.36 90 70318 6827 29497292
Product use issue 79.22 13.36 286 70122 51158 29452961
Epstein-Barr virus infection 79.05 13.36 88 70320 6541 29497578
Pain in extremity 78.81 13.36 88 70320 110345 29393774
Dyspnoea 78.53 13.36 457 69951 326275 29177844
Malaise 77.66 13.36 165 70243 159437 29344682
Drug hypersensitivity 77.30 13.36 33 70375 68373 29435746
Blood glucose increased 75.91 13.36 23 70385 58961 29445158
Azoospermia 74.10 13.36 30 70378 375 29503744
Confusional state 73.90 13.36 119 70289 127758 29376361
End stage renal disease 73.51 13.36 91 70317 7573 29496546
Left ventricular dysfunction 73.30 13.36 98 70310 8804 29495315
Aspergillus infection 73 13.36 107 70301 10474 29493645
Cytokine release syndrome 71.47 13.36 119 70289 13000 29491119
Anaplastic lymphoma kinase gene mutation 69.88 13.36 21 70387 97 29504022
Cerebrovascular accident 69.64 13.36 49 70359 76862 29427257
Intentional product misuse 69.62 13.36 3 70405 34658 29469461
Candida infection 68.54 13.36 127 70281 15098 29489021
Stomatitis 67.36 13.36 218 70190 36895 29467224
Viral haemorrhagic cystitis 66.25 13.36 36 70372 904 29503215
Myelopathy 65.94 13.36 47 70361 1927 29502192
Aggression 65.51 13.36 5 70403 35536 29468583
Pneumonitis 65.38 13.36 180 70228 27864 29476255
Hospitalisation 64.73 13.36 15 70393 45973 29458146
Neurotoxicity 64.67 13.36 121 70287 14492 29489627
Blood creatine phosphokinase increased 64.12 13.36 10 70398 40634 29463485
Haemophagocytic lymphohistiocytosis 63.65 13.36 100 70308 10404 29493715
Bradycardia 63.21 13.36 39 70369 65590 29438529
Peripheral sensory neuropathy 62.64 13.36 74 70334 5865 29498254
Suicide attempt 62.31 13.36 5 70403 34105 29470014
Chest pain 61.17 13.36 108 70300 111865 29392254
Osteonecrosis 61.15 13.36 113 70295 13406 29490713
Coronary artery disease 61.04 13.36 15 70393 44175 29459944
Rheumatoid arthritis 60.78 13.36 4 70404 32148 29471971
Post transplant lymphoproliferative disorder 60.53 13.36 70 70338 5423 29498696
Venoocclusive disease 59.60 13.36 49 70359 2490 29501629
Hallucination 58.32 13.36 17 70391 44695 29459424
Musculoskeletal stiffness 57.34 13.36 10 70398 37448 29466671
Traumatic lung injury 56.10 13.36 35 70373 1145 29502974
Hypoglycaemia 55.12 13.36 23 70385 48323 29455796
Inappropriate schedule of product administration 54.29 13.36 19 70389 44453 29459666
JC virus infection 53.97 13.36 41 70367 1856 29502263
Multiple organ dysfunction syndrome 53.74 13.36 294 70114 62822 29441297
Escherichia sepsis 53.35 13.36 56 70352 3893 29500226
Salivary gland cancer 52.86 13.36 21 70387 249 29503870
Cystitis haemorrhagic 52.18 13.36 61 70347 4781 29499338
Central nervous system lymphoma 51.43 13.36 28 70380 706 29503413
Strongyloidiasis 50.91 13.36 43 70365 2269 29501850
Malignant transformation 50.75 13.36 29 70379 805 29503314
Bronchopulmonary aspergillosis 50.66 13.36 99 70309 12245 29491874
Nasopharyngitis 50.17 13.36 41 70367 59624 29444495
Chloroma 49.93 13.36 24 70384 462 29503657
B-cell lymphoma refractory 49.71 13.36 17 70391 127 29503992
Back pain 49.48 13.36 106 70302 102178 29401941
Post embolisation syndrome 48.40 13.36 14 70394 55 29504064
Pneumonia klebsiella 47.86 13.36 44 70364 2600 29501519
Chronic obstructive pulmonary disease 47.47 13.36 19 70389 40936 29463183
Refractory cancer 46.62 13.36 16 70392 121 29503998
Intestinal perforation 46.27 13.36 75 70333 8011 29496108
Acute lymphocytic leukaemia 46.11 13.36 43 70365 2588 29501531
Contusion 46.09 13.36 9 70399 31086 29473033
Neutropenic colitis 45.36 13.36 41 70367 2370 29501749
Gene mutation 44.82 13.36 29 70379 1012 29503107
Cardio-respiratory arrest 44.79 13.36 33 70375 50568 29453551
Escherichia infection 44.64 13.36 67 70341 6697 29497422
Hyperhidrosis 44.31 13.36 53 70355 64487 29439632
Incorrect dose administered 44.01 13.36 12 70396 32972 29471147
Infection 43.87 13.36 323 70085 76428 29427691
Nephropathy toxic 43.82 13.36 86 70322 10670 29493449
Memory impairment 43.80 13.36 16 70392 36454 29467665
Gastritis bacterial 43.77 13.36 17 70391 189 29503930
Infection reactivation 43.67 13.36 29 70379 1058 29503061
Fungal infection 43.64 13.36 99 70309 13586 29490533
Agitation 43.45 13.36 35 70373 51269 29452850
Abnormal behaviour 43.35 13.36 3 70405 23124 29480995
Interstitial lung disease 43.32 13.36 260 70148 57458 29446661
Administration site extravasation 43.28 13.36 22 70386 480 29503639
Lymphoma transformation 43.06 13.36 16 70392 156 29503963
Injection site pain 42.93 13.36 12 70396 32434 29471685
Wheezing 42.69 13.36 13 70395 33227 29470892
Psoriasis 42.49 13.36 12 70396 32215 29471904
Oedema peripheral 42.45 13.36 117 70291 103440 29400679
Lung infiltration 41.86 13.36 89 70319 11690 29492429
Gait disturbance 41.63 13.36 69 70339 73280 29430839
Abdominal discomfort 41.42 13.36 32 70376 47871 29456248
Sleep disorder 40.82 13.36 5 70403 24381 29479738
Loss of consciousness 40.81 13.36 71 70337 73985 29430134
Congenital cardiovascular anomaly 40.79 13.36 16 70392 183 29503936
Cytogenetic abnormality 40.73 13.36 25 70383 794 29503325
Loss of personal independence in daily activities 40.71 13.36 6 70402 25434 29478685
Nephrolithiasis 40.49 13.36 6 70402 25328 29478791
Asthma 40.40 13.36 15 70393 33834 29470285
Peripheral T-cell lymphoma unspecified 40.25 13.36 20 70388 415 29503704
Aplasia 40.19 13.36 49 70359 4014 29500105
Colitis 40.09 13.36 164 70244 31084 29473035
Heart rate decreased 39.58 13.36 6 70402 24906 29479213
Autoimmune neutropenia 39.02 13.36 17 70391 258 29503861
Urticaria 38.47 13.36 44 70364 54616 29449503
Blood stem cell transplant failure 38.04 13.36 19 70389 399 29503720
Diarrhoea 37.94 13.36 561 69847 332137 29171982
Unevaluable event 37.75 13.36 12 70396 29839 29474280
BK virus infection 37.50 13.36 51 70357 4656 29499463
Staphylococcal sepsis 37.50 13.36 72 70336 8790 29495329
Platelet count decreased 36.31 13.36 395 70013 104277 29399842
Retinal haemorrhage 36.19 13.36 49 70359 4455 29499664
Endocarditis noninfective 36.10 13.36 13 70395 115 29504004
Agranulocytosis 35.56 13.36 118 70290 20222 29483897
Osteosarcoma recurrent 34.90 13.36 9 70399 20 29504099
Arthropathy 34.69 13.36 5 70403 21549 29482570
Congestive cardiomyopathy 34.59 13.36 59 70349 6571 29497548
Bacteraemia 34.36 13.36 101 70307 16222 29487897
Injury 34.21 13.36 3 70405 19043 29485076
Balance disorder 34.12 13.36 22 70386 36148 29467971
Transformation to acute myeloid leukaemia 34.02 13.36 21 70387 674 29503445
Chronic myeloid leukaemia 33.82 13.36 32 70376 1962 29502157
Therapy non-responder 33.36 13.36 154 70254 30757 29473362
Device related thrombosis 33.10 13.36 23 70385 905 29503214
Ganglioneuroblastoma 32.97 13.36 9 70399 27 29504092
Pseudomonas infection 32.94 13.36 77 70331 10775 29493344
Autoimmune lymphoproliferative syndrome 32.81 13.36 13 70395 153 29503966
Haemoglobin abnormal 32.70 13.36 39 70369 3122 29500997
Syncope 32.55 13.36 93 70315 81278 29422841
Cardiac failure congestive 32.52 13.36 85 70323 76496 29427623
Cytomegalovirus infection reactivation 32.35 13.36 40 70368 3324 29500795
Epstein-Barr virus associated lymphoma 32.20 13.36 19 70389 561 29503558
Angioedema 32.08 13.36 18 70390 31897 29472222
Hyperkalaemia 31.91 13.36 61 70347 61331 29442788
Hepatic fibrosis 31.81 13.36 39 70369 3213 29500906
Mobility decreased 31.48 13.36 11 70397 25769 29478350
Subdural hygroma 31.43 13.36 15 70393 284 29503835
Glioma 31.34 13.36 15 70393 286 29503833
Cardiac arrest 31.26 13.36 102 70306 85489 29418630
Lymphoma 31.23 13.36 71 70337 9757 29494362
Heart rate increased 31.21 13.36 28 70380 38910 29465209
Acute lymphocytic leukaemia recurrent 31.03 13.36 34 70374 2482 29501637
International normalised ratio increased 30.92 13.36 36 70372 44336 29459783
Vision blurred 30.89 13.36 30 70378 40146 29463973
5q minus syndrome 30.77 13.36 12 70396 135 29503984
Pneumothorax spontaneous 30.71 13.36 16 70392 368 29503751
Respiratory failure 30.71 13.36 360 70048 96771 29407348
Peripheral motor neuropathy 30.71 13.36 28 70380 1637 29502482
Recurrent cancer 30.57 13.36 24 70384 1141 29502978
Mass 30.36 13.36 58 70350 7053 29497066
Hepatosplenic candidiasis 30.28 13.36 13 70395 190 29503929
Chest discomfort 30.26 13.36 39 70369 45944 29458175
Gastrointestinal toxicity 30.19 13.36 31 70377 2100 29502019
Toxic erythema of chemotherapy 30.05 13.36 10 70398 68 29504051
Pneumonia 29.62 13.36 983 69425 319189 29184930
Device related infection 29.40 13.36 93 70315 15543 29488576
Viral load increased 29.38 13.36 30 70378 2019 29502100
Drug withdrawal syndrome 29.34 13.36 4 70404 17980 29486139
Haematochezia 29.16 13.36 27 70381 36956 29467163
Klebsiella infection 29.02 13.36 58 70350 7291 29496828
Blood HIV RNA increased 28.84 13.36 22 70386 1002 29503117
Cardiomyopathy acute 28.83 13.36 8 70400 26 29504093
Metastases to lung 28.66 13.36 60 70348 7795 29496324
Renal tubular disorder 28.57 13.36 43 70365 4309 29499810
Splenic lesion 28.26 13.36 11 70397 123 29503996
Drug clearance decreased 28.25 13.36 25 70383 1405 29502714
Herpes simplex encephalitis 28.16 13.36 14 70394 291 29503828
Metastases to spleen 28.03 13.36 15 70393 365 29503754
Abdominal pain upper 28.01 13.36 65 70343 60928 29443191
Gastric perforation 27.76 13.36 30 70378 2156 29501963
Tidal volume decreased 27.54 13.36 8 70400 32 29504087
Skin toxicity 27.27 13.36 39 70369 3732 29500387
Mucosal toxicity 27.26 13.36 12 70396 187 29503932
Pneumonia fungal 27.02 13.36 49 70359 5728 29498391
Primitive neuroectodermal tumour 26.94 13.36 9 70399 62 29504057
Toxicity to various agents 26.86 13.36 274 70134 173387 29330732
Respiratory arrest 26.80 13.36 14 70394 25819 29478300
Blood cholesterol increased 26.59 13.36 3 70405 15592 29488527
Encephalitis enteroviral 26.58 13.36 11 70397 146 29503973
Road traffic accident 26.51 13.36 3 70405 15558 29488561
Disorientation 26.44 13.36 19 70389 29496 29474623
Ototoxicity 26.32 13.36 25 70383 1540 29502579
Accidental overdose 26.27 13.36 5 70403 17588 29486531
Ill-defined disorder 26.26 13.36 74 70334 11604 29492515
Pulmonary toxicity 26.15 13.36 44 70364 4846 29499273
Secondary immunodeficiency 26.15 13.36 14 70394 341 29503778
Gastrooesophageal reflux disease 26.03 13.36 22 70386 31474 29472645
Hypertriglyceridaemia 26.00 13.36 56 70352 7419 29496700
Haemorrhage 25.94 13.36 42 70366 45030 29459089
Plasmacytoma 25.86 13.36 35 70373 3180 29500939
Hypertension 25.83 13.36 167 70241 116447 29387672
Intestinal atresia 25.78 13.36 9 70399 72 29504047
Metastases to retroperitoneum 25.75 13.36 12 70396 215 29503904
Myelitis transverse 25.58 13.36 20 70388 945 29503174
West Nile viral infection 25.29 13.36 17 70391 633 29503486
Chylothorax 25.22 13.36 17 70391 636 29503483
Biliary-bronchial fistula 25.21 13.36 5 70403 0 29504119
Cardiac dysfunction 25.08 13.36 26 70382 1781 29502338
Peripheral sensorimotor neuropathy 25.06 13.36 23 70385 1356 29502763
Gastrointestinal haemorrhage 24.93 13.36 101 70307 79432 29424687
Product quality issue 24.86 13.36 4 70404 15891 29488228
Hepatic infection fungal 24.73 13.36 11 70397 176 29503943
Refractory anaemia with an excess of blasts 24.68 13.36 14 70394 383 29503736
Cardiac failure 24.67 13.36 293 70115 78994 29425125
Cerebral toxoplasmosis 24.54 13.36 23 70385 1393 29502726
Irritability 24.51 13.36 11 70397 22141 29481978
Mucormycosis 24.44 13.36 44 70364 5114 29499005
Cellulitis gangrenous 24.39 13.36 11 70397 182 29503937
Psychotic disorder 24.32 13.36 9 70399 20345 29483774
Pleural effusion 24.28 13.36 270 70138 71638 29432481
Testicular disorder 24.28 13.36 16 70392 576 29503543
Cardiac disorder 24.11 13.36 32 70376 37231 29466888
Depressed mood 23.88 13.36 5 70403 16443 29487676
Osteosarcoma 23.86 13.36 11 70397 192 29503927
Molluscum contagiosum 23.81 13.36 12 70396 257 29503862
Hypersensitivity 23.79 13.36 57 70351 52846 29451273
Blood pressure decreased 23.79 13.36 45 70363 45432 29458687
Weight decreased 23.78 13.36 237 70171 150668 29353451
Acute lymphocytic leukaemia refractory 23.67 13.36 9 70399 94 29504025
Meningitis cryptococcal 23.54 13.36 27 70381 2073 29502046
Meningitis tuberculous 23.49 13.36 16 70392 609 29503510
Pulmonary sarcoidosis 23.47 13.36 15 70393 512 29503607
Neurofibrosarcoma 23.35 13.36 7 70401 32 29504087
Head injury 23.11 13.36 5 70403 16076 29488043
Metastases to muscle 22.97 13.36 11 70397 210 29503909
Escherichia bacteraemia 22.82 13.36 31 70377 2827 29501292
Unresponsive to stimuli 22.73 13.36 16 70392 25110 29479009
Palmar-plantar erythrodysaesthesia syndrome 22.65 13.36 82 70326 14677 29489442
Drug reaction with eosinophilia and systemic symptoms 22.58 13.36 20 70388 27972 29476147
Lentigo 22.52 13.36 13 70395 368 29503751
Morphoea 22.48 13.36 10 70398 160 29503959
Infusion site discolouration 22.41 13.36 9 70399 110 29504009
Glioblastoma multiforme 22.34 13.36 16 70392 661 29503458
Enterovirus infection 22.34 13.36 16 70392 661 29503458
Haematopoietic stem cell mobilisation 22.31 13.36 10 70398 163 29503956
Pneumocystis jirovecii infection 22.23 13.36 22 70386 1426 29502693
Cutaneous T-cell lymphoma recurrent 22.21 13.36 7 70401 39 29504080
Gait inability 22.16 13.36 8 70400 18367 29485752
Transient ischaemic attack 22.15 13.36 14 70394 23256 29480863
Adverse drug reaction 22.12 13.36 15 70393 24005 29480114
COVID-19 pneumonia 22.06 13.36 61 70347 9461 29494658
Stevens-Johnson syndrome 22.01 13.36 6 70402 16491 29487628
Periorbital infection 21.98 13.36 9 70399 116 29504003
Treatment failure 21.97 13.36 157 70251 36782 29467337
Acute lung injury 21.86 13.36 21 70387 1312 29502807
Faeces discoloured 21.71 13.36 3 70405 13348 29490771
Bacterial infection 21.64 13.36 74 70334 12874 29491245
Clostridium difficile colitis 21.64 13.36 75 70333 13137 29490982
Phlebitis infective 21.64 13.36 9 70399 121 29503998
Blood urea increased 21.60 13.36 21 70387 28091 29476028
Intentional product use issue 21.56 13.36 174 70234 42324 29461795
Positron emission tomogram abnormal 21.38 13.36 9 70399 125 29503994
Sphingomonas paucimobilis infection 21.37 13.36 7 70401 45 29504074
Fluid retention 21.32 13.36 15 70393 23545 29480574
Spindle cell sarcoma 21.31 13.36 9 70399 126 29503993
Oesophageal candidiasis 21.26 13.36 35 70373 3786 29500333
Hepatitis viral 21.22 13.36 14 70394 505 29503614
Streptococcal infection 20.90 13.36 38 70370 4450 29499669
Blood pressure systolic increased 20.89 13.36 7 70401 16838 29487281
Burning sensation 20.89 13.36 6 70402 15932 29488187
Dry skin 20.88 13.36 15 70393 23292 29480827
Suspected product quality issue 20.81 13.36 9 70399 134 29503985
Injection site erythema 20.76 13.36 4 70404 13952 29490167
Disorder of orbit 20.75 13.36 8 70400 87 29504032
Salivary gland neoplasm 20.66 13.36 6 70402 24 29504095
Cancer fatigue 20.62 13.36 7 70401 51 29504068
Oxygen saturation decreased 20.54 13.36 48 70360 44889 29459230
Disseminated cytomegaloviral infection 20.50 13.36 10 70398 199 29503920
Taeniasis 20.50 13.36 7 70401 52 29504067
Herpes zoster 20.42 13.36 132 70276 29920 29474199
Scedosporium infection 20.23 13.36 16 70392 769 29503350
Restlessness 20.17 13.36 14 70394 22131 29481988
Clostridium difficile infection 20.14 13.36 84 70324 16057 29488062
Splenic marginal zone lymphoma 20.09 13.36 6 70402 27 29504092
Acute pulmonary histoplasmosis 19.95 13.36 9 70399 149 29503970
Treatment noncompliance 19.92 13.36 17 70391 24210 29479909
Sarcoma metastatic 19.84 13.36 7 70401 58 29504061
Mucoepidermoid carcinoma of salivary gland 19.75 13.36 5 70403 10 29504109
Marginal zone lymphoma recurrent 19.74 13.36 6 70402 29 29504090
Metastases to bone marrow 19.70 13.36 13 70395 469 29503650
Pulmonary embolism 19.65 13.36 273 70135 76261 29427858
Extravasation 19.60 13.36 22 70386 1650 29502469
Electrocardiogram QT prolonged 19.57 13.36 35 70373 36102 29468017
Plasmablastic lymphoma 19.56 13.36 10 70398 221 29503898
Candida endophthalmitis 19.55 13.36 8 70400 103 29504016
Hepatic amoebiasis 19.53 13.36 7 70401 61 29504058
Hepatitis B DNA increased 19.32 13.36 13 70395 485 29503634
Wrong technique in product usage process 19.32 13.36 28 70380 31400 29472719
Adenocarcinoma gastric 19.28 13.36 18 70390 1085 29503034
Swelling 19.27 13.36 34 70374 35249 29468870
Rash pruritic 19.25 13.36 15 70393 22348 29481771
Bone marrow disorder 19.19 13.36 21 70387 1531 29502588
Hepatitis 19.16 13.36 99 70309 20684 29483435
Labelled drug-drug interaction medication error 19.15 13.36 3 70405 12156 29491963
Sleep apnoea syndrome 19.06 13.36 9 70399 17590 29486529
Toxic cardiomyopathy 18.92 13.36 10 70398 237 29503882
Ileus 18.79 13.36 76 70332 14326 29489793
Nausea 18.75 13.36 535 69873 288720 29215399
Gastric stenosis 18.67 13.36 6 70402 36 29504083
Flushing 18.65 13.36 25 70383 28967 29475152
Laboratory test abnormal 18.65 13.36 10 70398 18175 29485944
Hypoaesthesia 18.63 13.36 65 70343 53402 29450717
Splenic candidiasis 18.42 13.36 7 70401 73 29504046
Swelling face 18.35 13.36 13 70395 20337 29483782
Superior vena cava syndrome 18.34 13.36 13 70395 528 29503591
Surgery 18.34 13.36 3 70405 11776 29492343
Systemic mycosis 18.32 13.36 19 70389 1302 29502817
Venous thrombosis 18.20 13.36 29 70379 3053 29501066
Scleroderma 18.12 13.36 19 70389 1319 29502800
Blood lactate dehydrogenase increased 18.06 13.36 92 70316 19117 29485002
Premature ageing 17.85 13.36 7 70401 80 29504039
Abdominal neoplasm 17.80 13.36 9 70399 194 29503925
Diabetic ketoacidosis 17.75 13.36 8 70400 16065 29488054
Immunosuppression 17.70 13.36 39 70369 5247 29498872
Chronic lymphocytic leukaemia refractory 17.70 13.36 7 70401 82 29504037
Chromosome analysis abnormal 17.65 13.36 8 70400 134 29503985
Total lung capacity decreased 17.61 13.36 13 70395 563 29503556
B precursor type acute leukaemia 17.60 13.36 8 70400 135 29503984
B-cell type acute leukaemia 17.58 13.36 10 70398 275 29503844
Nightmare 17.57 13.36 3 70405 11414 29492705
Lip swelling 17.55 13.36 4 70404 12406 29491713
Cryptococcal fungaemia 17.40 13.36 7 70401 86 29504033
Seizure 17.39 13.36 140 70268 92983 29411136
Dysgeusia 17.35 13.36 17 70391 22657 29481462
Amnesia 17.30 13.36 17 70391 22626 29481493
Helicobacter sepsis 17.21 13.36 5 70403 20 29504099
Facial paresis 17.20 13.36 26 70382 2615 29501504
IIIrd nerve paresis 17.18 13.36 7 70401 89 29504030
Acute hepatic failure 17.16 13.36 65 70343 11887 29492232
Plasma cell myeloma refractory 17.11 13.36 7 70401 90 29504029
Injection site reaction 17.09 13.36 3 70405 11185 29492934
Pneumonia salmonella 17.08 13.36 6 70402 49 29504070
Hot flush 17.06 13.36 7 70401 14863 29489256
Rhabdomyosarcoma recurrent 17.04 13.36 7 70401 91 29504028
Fanconi syndrome 17.00 13.36 20 70388 1578 29502541
Focal nodular hyperplasia 16.98 13.36 8 70400 147 29503972
Abdominal wound dehiscence 16.91 13.36 7 70401 93 29504026
Fusarium infection 16.91 13.36 16 70392 981 29503138
Postural tremor 16.86 13.36 10 70398 298 29503821
Granulocytopenia neonatal 16.83 13.36 5 70403 22 29504097
Visual impairment 16.79 13.36 28 70380 29680 29474439
Cholelithiasis 16.75 13.36 12 70396 18660 29485459
Eczema 16.71 13.36 6 70402 13820 29490299
Small intestinal perforation 16.66 13.36 20 70388 1612 29502507
Lactic acidosis 16.65 13.36 29 70379 30218 29473901
Ichthyosis 16.64 13.36 7 70401 97 29504022
Liver function test abnormal 16.59 13.36 27 70381 28891 29475228
Guillain-Barre syndrome 16.58 13.36 37 70371 5021 29499098
Disturbance in attention 16.46 13.36 16 70392 21408 29482711
Wound evisceration 16.45 13.36 7 70401 100 29504019
Disseminated cryptococcosis 16.44 13.36 17 70391 1161 29502958
Resorption bone increased 16.41 13.36 8 70400 159 29503960
Drug ineffective for unapproved indication 16.21 13.36 72 70336 14142 29489977
Skin exfoliation 16.18 13.36 18 70390 22627 29481492
Respiratory depression 16.12 13.36 6 70402 13517 29490602
Benign prostatic hyperplasia 16.12 13.36 4 70404 11706 29492413
Renal disorder 16.10 13.36 18 70390 22577 29481542
Vertigo 16.03 13.36 17 70391 21844 29482275
Mastitis 16.01 13.36 8 70400 168 29503951
Combined immunodeficiency 16.01 13.36 6 70402 60 29504059
Dementia 16.01 13.36 4 70404 11654 29492465
Metastasis 15.93 13.36 29 70379 3400 29500719
Plasma cell leukaemia 15.88 13.36 14 70394 783 29503336
Therapy responder 15.84 13.36 8 70400 172 29503947
Blindness cortical 15.82 13.36 10 70398 335 29503784
Hallucination, visual 15.78 13.36 8 70400 15007 29489112
Musculoskeletal pain 15.72 13.36 28 70380 28925 29475194
Hepatotoxicity 15.71 13.36 84 70324 17783 29486336
Adrenocortical carcinoma 15.70 13.36 5 70403 29 29504090
Congenital hepatobiliary anomaly 15.70 13.36 5 70403 29 29504090
Depressed level of consciousness 15.67 13.36 41 70367 36901 29467218
Blastic plasmacytoid dendritic cell neoplasia 15.67 13.36 6 70402 64 29504055
Hip fracture 15.62 13.36 3 70405 10489 29493630
Myeloid leukaemia 15.58 13.36 10 70398 344 29503775
Leukonychia 15.48 13.36 4 70404 9 29504110
Bone marrow infiltration 15.46 13.36 7 70401 117 29504002
Neoplasm 15.43 13.36 32 70376 4129 29499990
Lymphocytosis 15.42 13.36 21 70387 1919 29502200
Neuroborreliosis 15.42 13.36 5 70403 31 29504088
Mental status changes 15.41 13.36 38 70370 34889 29469230
Dyskinesia 15.40 13.36 15 70393 20046 29484073
Enterococcal infection 15.38 13.36 49 70359 8219 29495900
Erythema 15.37 13.36 111 70297 75495 29428624
Pneumonia mycoplasmal 15.35 13.36 12 70396 567 29503552
Candida sepsis 15.30 13.36 16 70392 1107 29503012
Heart disease congenital 15.27 13.36 17 70391 1263 29502856
Influenza 15.21 13.36 50 70358 41831 29462288
Leukoencephalopathy 15.20 13.36 30 70378 3737 29500382
Diabetes mellitus inadequate control 15.12 13.36 5 70403 12129 29491990
Delusion 15.11 13.36 4 70404 11212 29492907
Pseudomonal sepsis 15.11 13.36 26 70382 2916 29501203
Lewis-Sumner syndrome 15.02 13.36 5 70403 34 29504085
Paternal exposure timing unspecified 15.02 13.36 5 70403 34 29504085
Dehydration 14.98 13.36 188 70220 114560 29389559
Hepatitis C RNA increased 14.97 13.36 9 70399 275 29503844
Leukaemia 14.96 13.36 30 70378 3780 29500339
Neuroblastoma recurrent 14.89 13.36 6 70402 74 29504045
Influenza like illness 14.84 13.36 22 70386 24448 29479671
Coronary artery occlusion 14.79 13.36 3 70405 10091 29494028
Pneumaturia 14.78 13.36 5 70403 36 29504083
Genotoxicity 14.78 13.36 5 70403 36 29504083
Humoral immune defect 14.75 13.36 6 70402 76 29504043
Chemotherapeutic drug level increased 14.68 13.36 8 70400 202 29503917
Spinal cord ischaemia 14.68 13.36 6 70402 77 29504042
Therapeutic product effect decreased 14.66 13.36 30 70378 29421 29474698
Metapneumovirus bronchiolitis 14.65 13.36 4 70404 12 29504107
Peripheral T-cell lymphoma unspecified refractory 14.65 13.36 4 70404 12 29504107
Granulocyte count decreased 14.56 13.36 12 70396 612 29503507
Acute hepatitis B 14.55 13.36 7 70401 135 29503984
Asthenia 14.46 13.36 396 70012 214854 29289265
Plasma cell myeloma recurrent 14.46 13.36 29 70379 3654 29500465
Metastases to meninges 14.37 13.36 16 70392 1189 29502930
Metabolic acidosis 14.36 13.36 44 70364 37618 29466501
Extrapyramidal disorder 14.34 13.36 4 70404 10827 29493292
Neck pain 14.30 13.36 18 70390 21429 29482690
Hepatosplenomegaly 14.28 13.36 29 70379 3688 29500431
Hypersomnia 14.18 13.36 4 70404 10750 29493369
Oligohydramnios 14.17 13.36 9 70399 304 29503815
Cytomegalovirus viraemia 14.16 13.36 40 70368 6280 29497839
Neutrophil count increased 14.13 13.36 71 70337 14671 29489448
Sudden death 14.12 13.36 8 70400 14102 29490017
Cryptosporidiosis infection 14.09 13.36 10 70398 407 29503712
Visual acuity reduced 14.09 13.36 9 70399 14867 29489252
Hypercalcaemia 14.08 13.36 64 70344 12695 29491424
Sinusitis bacterial 14.06 13.36 9 70399 308 29503811
Exophthalmos 14.05 13.36 11 70397 521 29503598
Optic ischaemic neuropathy 14.05 13.36 20 70388 1906 29502213
Respiratory tract infection 14.04 13.36 74 70334 15577 29488542
Stomatitis necrotising 14.02 13.36 6 70402 87 29504032
VIth nerve paresis 14.01 13.36 5 70403 43 29504076
Abdominal mass 14.00 13.36 16 70392 1224 29502895
Embolism 13.87 13.36 42 70366 6854 29497265
Central nervous system enteroviral infection 13.81 13.36 5 70403 45 29504074
Blindness 13.79 13.36 61 70347 11962 29492157
Coxsackie viral infection 13.77 13.36 4 70404 16 29504103
Torulopsis infection 13.77 13.36 4 70404 16 29504103
Coma 13.72 13.36 48 70360 39402 29464717
Swollen tongue 13.71 13.36 6 70402 12260 29491859
Haemoptysis 13.66 13.36 33 70375 30517 29473602
Gingivitis ulcerative 13.62 13.36 5 70403 47 29504072
Stem cell transplant 13.57 13.36 20 70388 1967 29502152
Pneumonia respiratory syncytial viral 13.55 13.36 13 70395 811 29503308
Systemic candida 13.54 13.36 24 70384 2756 29501363
Chronic myelomonocytic leukaemia 13.53 13.36 11 70397 550 29503569
Procedural pneumothorax 13.52 13.36 5 70403 48 29504071
Human polyomavirus infection 13.49 13.36 12 70396 679 29503440
Hip deformity 13.49 13.36 6 70402 96 29504023
Cutaneous T-cell lymphoma 13.45 13.36 16 70392 1277 29502842
Febrile infection 13.44 13.36 20 70388 1984 29502135
Tuberculosis liver 13.43 13.36 5 70403 49 29504070
Subclavian vein thrombosis 13.40 13.36 13 70395 822 29503297

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 7040.98 12.06 4594 134312 183063 64176763
Neutropenia 2884.95 12.06 3037 135869 236587 64123239
Acute myeloid leukaemia 1378.86 12.06 813 138093 26650 64333176
Product use in unapproved indication 1366.85 12.06 1788 137118 174830 64184996
Myelodysplastic syndrome 1205.40 12.06 747 138159 26832 64332994
Mucosal inflammation 1202.34 12.06 1030 137876 61554 64298272
Second primary malignancy 1192.92 12.06 566 138340 11771 64348055
Haematotoxicity 1166.02 12.06 565 138341 12331 64347495
Off label use 1032.94 12.06 3342 135564 629464 63730362
Cardiotoxicity 1007.55 12.06 476 138430 9798 64350028
Bone marrow failure 914.22 12.06 786 138120 47166 64312660
Disease progression 903.14 12.06 1307 137599 140373 64219453
Thrombocytopenia 857.56 12.06 1642 137264 222159 64137667
Pancytopenia 808.86 12.06 1249 137657 142060 64217766
Diffuse large B-cell lymphoma recurrent 802.72 12.06 289 138617 2857 64356969
Hepatitis B 702.07 12.06 340 138566 7405 64352421
Malignant neoplasm progression 670.90 12.06 1008 137898 111863 64247963
Pneumocystis jirovecii pneumonia 605.32 12.06 491 138415 27143 64332683
Febrile bone marrow aplasia 598.44 12.06 346 138560 10909 64348917
Hepatitis B reactivation 594.10 12.06 263 138643 4626 64355200
Myelosuppression 585.44 12.06 453 138453 23377 64336449
Tumour lysis syndrome 567.84 12.06 410 138496 19030 64340796
Cardiomyopathy 560.60 12.06 453 138453 24903 64334923
Interstitial lung disease 519.29 12.06 829 138077 96903 64262923
Neutropenic sepsis 471.02 12.06 395 138511 22877 64336949
Ejection fraction decreased 443.16 12.06 418 138488 28289 64331537
Fall 438.44 12.06 175 138731 416651 63943175
Neoplasm progression 416.79 12.06 477 138429 40487 64319339
Leukopenia 413.10 12.06 764 138142 100478 64259348
Septic shock 409.48 12.06 779 138127 104658 64255168
Joint swelling 375.49 12.06 22 138884 215360 64144466
Pyrexia 373.92 12.06 2263 136643 556381 63803445
Neuropathy peripheral 373.68 12.06 799 138107 116726 64243100
Neutrophil count decreased 368.34 12.06 624 138282 76572 64283254
Sepsis 341.17 12.06 1181 137725 229160 64130666
Pain 336.08 12.06 420 138486 553091 63806735
Therapy partial responder 336.01 12.06 232 138674 10016 64349810
Rheumatoid arthritis 323.80 12.06 6 138900 164288 64195538
Posterior reversible encephalopathy syndrome 318.14 12.06 315 138591 22631 64337195
Anaemia 318.10 12.06 1632 137274 377048 63982778
Arthralgia 315.62 12.06 293 138613 441967 63917859
Palmar-plantar erythrodysaesthesia syndrome 304.01 12.06 342 138564 28477 64331349
Cytopenia 297.46 12.06 255 138651 15216 64344610
Product dose omission issue 288.30 12.06 39 138867 194708 64165118
Peripheral swelling 278.25 12.06 56 138850 209097 64150729
Acquired gene mutation 267.86 12.06 115 138791 1871 64357955
Headache 264.36 12.06 460 138446 529007 63830819
Left ventricular dysfunction 263.79 12.06 248 138658 16706 64343120
Progressive multifocal leukoencephalopathy 255.92 12.06 252 138654 17980 64341846
Diffuse large B-cell lymphoma refractory 252.42 12.06 94 138812 1030 64358796
Dizziness 248.87 12.06 338 138568 429825 63930001
Metastases to bone 246.01 12.06 260 138646 20175 64339651
Drug hypersensitivity 244.57 12.06 103 138803 237712 64122114
Weight increased 241.90 12.06 79 138827 213269 64146557
Pruritus 227.35 12.06 203 138703 312197 64047629
Drug abuse 226.18 12.06 15 138891 132359 64227467
Disease recurrence 218.43 12.06 303 138603 31207 64328619
Cardiac failure 218.13 12.06 704 138202 131669 64228157
Abdominal discomfort 216.61 12.06 62 138844 182260 64177566
Congestive cardiomyopathy 210.14 12.06 176 138730 10168 64349658
Cytomegalovirus chorioretinitis 209.28 12.06 131 138775 4781 64355045
Rash 204.51 12.06 426 138480 458123 63901703
Nasopharyngitis 201.42 12.06 85 138821 195988 64163838
B-cell lymphoma recurrent 199.44 12.06 73 138833 759 64359067
Metastases to lung 192.30 12.06 199 138707 15065 64344761
Musculoskeletal stiffness 191.29 12.06 21 138885 123185 64236641
Synovitis 189.79 12.06 5 138901 99085 64260741
Insomnia 188.89 12.06 95 138811 197741 64162085
White blood cell count decreased 187.24 12.06 754 138152 157083 64202743
Polyneuropathy 181.26 12.06 219 138687 19675 64340151
Anxiety 180.81 12.06 106 138800 202543 64157283
Multiple organ dysfunction syndrome 179.55 12.06 553 138353 100860 64258966
Somnolence 175.45 12.06 111 138795 203534 64156292
Lymphadenopathy 174.99 12.06 340 138566 46346 64313480
Intentional overdose 174.32 12.06 4 138902 89940 64269886
Arthropathy 172.51 12.06 27 138879 120940 64238886
Blood pressure increased 170.60 12.06 79 138827 172473 64187353
Acute promyelocytic leukaemia 169.69 12.06 75 138831 1313 64358513
Overdose 165.75 12.06 68 138838 159498 64200328
Muscle spasms 163.74 12.06 50 138856 140973 64218853
Pain in extremity 163.39 12.06 250 138656 302835 64056991
Haemophagocytic lymphohistiocytosis 162.31 12.06 195 138711 17414 64342412
Swelling 162.07 12.06 71 138835 160147 64199679
Neutropenic colitis 160.35 12.06 108 138798 4473 64355353
Aplasia 157.39 12.06 126 138780 6827 64352999
Injection site pain 156.32 12.06 26 138880 111382 64248444
Feeling abnormal 155.78 12.06 47 138859 133555 64226271
Metastases to liver 153.77 12.06 222 138684 23719 64336107
Pneumonitis 151.43 12.06 335 138571 50030 64309796
Platelet count decreased 148.18 12.06 734 138172 166977 64192849
Contusion 146.39 12.06 33 138873 113932 64245894
Peripheral sensory neuropathy 144.52 12.06 149 138757 11229 64348597
Mantle cell lymphoma recurrent 143.98 12.06 50 138856 440 64359386
Neurotoxicity 143.34 12.06 231 138675 27173 64332653
Drug resistance 141.87 12.06 264 138642 34838 64324988
Pleural effusion 141.67 12.06 594 138312 125965 64233861
Intentional product misuse 140.93 12.06 3 138903 72292 64287534
Malaise 137.01 12.06 419 138487 395828 63963998
Anti-Muellerian hormone level decreased 137.00 12.06 34 138872 70 64359756
Drug interaction 133.06 12.06 372 138534 361711 63998115
Urticaria 132.87 12.06 76 138830 147241 64212585
Myocardial infarction 131.35 12.06 99 138807 165722 64194104
Epstein-Barr virus infection 129.63 12.06 147 138759 12341 64347485
Hepatic failure 127.27 12.06 332 138574 55062 64304764
Stomatitis 127.03 12.06 520 138386 109085 64250741
Confusional state 125.37 12.06 232 138674 260912 64098914
Rhabdomyolysis 125.19 12.06 23 138883 91703 64268123
Gene mutation 124.12 12.06 69 138837 2013 64357813
Psoriasis 119.92 12.06 9 138897 71694 64288132
Fatigue 119.80 12.06 1035 137871 747695 63612131
Depression 119.49 12.06 131 138775 183160 64176666
Post transplant lymphoproliferative disorder 119.45 12.06 124 138782 9420 64350406
Lymphopenia 119.10 12.06 205 138701 25452 64334374
Therapeutic product effect decreased 116.82 12.06 51 138855 115300 64244526
Pemphigus 116.46 12.06 3 138903 60698 64299128
Venoocclusive disease 116.22 12.06 84 138822 3901 64355925
Diffuse large B-cell lymphoma 114.47 12.06 126 138780 10235 64349591
Contraindicated product administered 113.50 12.06 45 138861 107784 64252042
Venoocclusive liver disease 112.74 12.06 123 138783 9892 64349934
Bronchopulmonary aspergillosis 109.69 12.06 168 138738 18917 64340909
Neoplasm recurrence 109.47 12.06 79 138827 3660 64356166
Wound 109.18 12.06 17 138889 76460 64283366
Cytomegalovirus infection 109.08 12.06 245 138661 36954 64322872
Metastases to lymph nodes 108.64 12.06 113 138793 8604 64351222
Asthma 108.30 12.06 35 138871 95190 64264636
Discomfort 104.70 12.06 23 138883 80855 64278971
Hospitalisation 104.50 12.06 18 138888 75189 64284637
Cerebrovascular accident 104.08 12.06 86 138820 137497 64222329
Bone pain 104.08 12.06 280 138626 47292 64312534
Hypogammaglobulinaemia 101.45 12.06 118 138788 10181 64349645
Myelopathy 100.74 12.06 77 138829 3897 64355929
Cystitis haemorrhagic 100.71 12.06 104 138802 7852 64351974
Stress 100.09 12.06 8 138898 60526 64299300
Salivary gland cancer 99.33 12.06 36 138870 363 64359463
Sinusitis 98.79 12.06 101 138805 145827 64213999
Arthritis 98.56 12.06 29 138877 83785 64276041
Acute lymphocytic leukaemia 98.49 12.06 79 138827 4292 64355534
Bacteraemia 98.41 12.06 194 138712 26717 64333109
Intestinal perforation 98.34 12.06 142 138764 15171 64344655
Bradycardia 98.28 12.06 67 138839 118152 64241674
Staphylococcal bacteraemia 97.61 12.06 116 138790 10239 64349587
Hypoglycaemia 97.12 12.06 36 138870 89856 64269970
Injection site erythema 96.08 12.06 18 138888 70782 64289044
Glossodynia 95.55 12.06 13 138893 64683 64295143
Respiratory failure 94.11 12.06 632 138274 160551 64199275
Acute lymphocytic leukaemia recurrent 93.35 12.06 74 138832 3952 64355874
Tremor 93.26 12.06 109 138797 148121 64211705
Wheezing 92.73 12.06 29 138877 80550 64279276
Suicide attempt 92.30 12.06 20 138886 70987 64288839
Abdominal pain upper 91.71 12.06 147 138759 174883 64184943
Bronchitis 91.24 12.06 61 138845 108682 64251144
Herpes simplex 91.13 12.06 113 138793 10423 64349403
Ascites 90.73 12.06 317 138589 61684 64298142
Blood glucose increased 90.72 12.06 49 138857 98024 64261802
Traumatic lung injury 90.22 12.06 58 138848 2218 64357608
Hepatic enzyme increased 89.02 12.06 89 138817 129854 64229972
Aspergillus infection 88.30 12.06 140 138766 16239 64343587
Candida infection 87.76 12.06 203 138703 31216 64328610
Pulmonary toxicity 87.54 12.06 100 138806 8461 64351365
Heart rate decreased 86.43 12.06 9 138897 55058 64304768
Gait disturbance 85.20 12.06 150 138756 172005 64187821
Osteoarthritis 84.05 12.06 17 138889 63319 64296507
Sweat gland tumour 83.87 12.06 34 138872 475 64359351
Agranulocytosis 83.61 12.06 225 138681 38004 64321822
Skin toxicity 83.02 12.06 86 138820 6516 64353310
Inappropriate schedule of product administration 82.63 12.06 48 138858 92238 64267588
Loss of personal independence in daily activities 81.73 12.06 27 138879 72427 64287399
Myeloid leukaemia 81.32 12.06 35 138871 573 64359253
Injury 80.94 12.06 12 138894 55980 64303846
JC virus infection 80.67 12.06 63 138843 3292 64356534
Nephropathy toxic 80.06 12.06 139 138767 17375 64342451
Osteonecrosis 79.51 12.06 183 138723 28046 64331780
Refractory anaemia with an excess of blasts 79.26 12.06 38 138868 808 64359018
Balance disorder 78.99 12.06 41 138865 83885 64275941
Metastasis 78.58 12.06 78 138828 5617 64354209
Smooth muscle cell neoplasm 78.41 12.06 38 138868 828 64358998
Suicidal ideation 78.28 12.06 23 138883 66519 64293307
5q minus syndrome 75.60 12.06 27 138879 260 64359566
Metastases to peritoneum 75.47 12.06 62 138844 3485 64356341
Leukaemia 74.52 12.06 72 138834 5016 64354810
Blood cholesterol increased 74.08 12.06 10 138896 50056 64309770
Malignant transformation 74.06 12.06 40 138866 1101 64358725
Injection site swelling 72.67 12.06 4 138902 41349 64318477
Cytokine release syndrome 72.38 12.06 147 138759 20682 64339144
Mobility decreased 72.21 12.06 48 138858 85792 64274034
Small intestinal obstruction 72.19 12.06 158 138748 23415 64336411
Bone marrow disorder 72.19 12.06 55 138851 2770 64357056
Systemic candida 71.71 12.06 72 138834 5257 64354569
Cardio-respiratory arrest 71.36 12.06 64 138842 98329 64261497
Anaplastic lymphoma kinase gene mutation 70.93 12.06 21 138885 103 64359723
Coronary artery disease 70.89 12.06 21 138885 60412 64299414
Klebsiella infection 70.88 12.06 113 138793 13168 64346658
Plasmacytoma 70.76 12.06 62 138844 3808 64356018
Remission not achieved 69.93 12.06 27 138879 329 64359497
Lung infiltration 69.73 12.06 145 138761 20744 64339082
Heart rate increased 69.41 12.06 66 138840 98609 64261217
Drug intolerance 69.04 12.06 193 138713 187799 64172027
Aggression 68.96 12.06 9 138897 46223 64313603
Injection site pruritus 68.58 12.06 3 138903 37823 64322003
Cytogenetic abnormality 68.55 12.06 37 138869 1017 64358809
Cardiomyopathy acute 68.44 12.06 24 138882 218 64359608
Colitis 68.43 12.06 279 138627 58395 64301431
Chest pain 68.28 12.06 269 138637 235711 64124115
Viral haemorrhagic cystitis 68.13 12.06 43 138863 1592 64358234
Psoriatic arthropathy 68.12 12.06 7 138899 43274 64316552
Chronic myeloid leukaemia 67.68 12.06 57 138849 3317 64356509
Myalgia 67.46 12.06 151 138755 158466 64201360
Respiratory arrest 66.71 12.06 16 138890 52969 64306857
Blood pressure fluctuation 66.63 12.06 15 138891 51856 64307970
Nephrolithiasis 66.39 12.06 8 138898 43675 64316151
Gastrointestinal toxicity 66.34 12.06 69 138837 5253 64354573
Metastases to central nervous system 65.67 12.06 112 138794 13800 64346026
Administration site extravasation 65.61 12.06 36 138870 1023 64358803
Injection site bruising 65.57 12.06 3 138903 36370 64323456
Injection site reaction 65.19 12.06 11 138895 46653 64313173
Peripheral T-cell lymphoma unspecified 64.84 12.06 30 138876 587 64359239
Irritable bowel syndrome 64.49 12.06 4 138902 37365 64322461
Metastases to breast 64.35 12.06 23 138883 222 64359604
Fibromyalgia 64.24 12.06 3 138903 35728 64324098
Central nervous system lymphoma 63.88 12.06 44 138862 1891 64357935
Musculoskeletal pain 63.74 12.06 49 138857 81245 64278581
Chronic obstructive pulmonary disease 63.53 12.06 37 138869 71011 64288815
Encephalopathy 62.61 12.06 272 138634 58547 64301279
Acute hepatitis B 61.87 12.06 26 138880 400 64359426
Drug reaction with eosinophilia and systemic symptoms 61.51 12.06 20 138886 54197 64305629
End stage renal disease 61.31 12.06 93 138813 10382 64349444
Incorrect dose administered 61.29 12.06 27 138879 60738 64299088
Breast cancer recurrent 61.01 12.06 48 138858 2535 64357291
Hallucination 60.82 12.06 41 138865 72747 64287079
Memory impairment 60.63 12.06 57 138849 85625 64274201
Neutrophil count abnormal 60.32 12.06 50 138856 2846 64356980
Loss of consciousness 60.07 12.06 145 138761 148220 64211606
Pneumonia 59.74 12.06 1602 137304 557974 63801852
Infection reactivation 59.68 12.06 43 138863 1987 64357839
Hyperhidrosis 58.97 12.06 112 138794 124808 64235018
Hypersensitivity 58.71 12.06 221 138685 196231 64163595
Lymphoma transformation 58.64 12.06 21 138885 204 64359622
Mucosal toxicity 58.27 12.06 26 138880 466 64359360
Recurrent cancer 58.01 12.06 45 138861 2328 64357498
International normalised ratio increased 58.00 12.06 51 138855 79116 64280710
Breast cancer metastatic 57.42 12.06 74 138832 7095 64352731
Peripheral motor neuropathy 57.17 12.06 49 138857 2921 64356905
Angioedema 57.00 12.06 31 138875 61790 64298036
Agitation 56.62 12.06 64 138842 88303 64271523
Fluid retention 56.26 12.06 29 138877 59577 64300249
Death 56.22 12.06 718 138188 481987 63877839
Blood creatine phosphokinase increased 56.01 12.06 28 138878 58530 64301296
Premature menopause 55.77 12.06 26 138880 518 64359308
Plasma cell leukaemia 55.28 12.06 37 138869 1516 64358310
Pneumonia fungal 55.08 12.06 81 138825 8796 64351030
Condition aggravated 54.43 12.06 526 138380 371900 63987926
Extravasation 54.28 12.06 49 138857 3131 64356695
Computerised tomogram thorax abnormal 54.01 12.06 40 138866 1929 64357897
BK virus infection 53.95 12.06 73 138833 7339 64352487
Enterococcal bacteraemia 53.75 12.06 44 138862 2461 64357365
Nasal congestion 53.44 12.06 31 138875 59627 64300199
Serotonin syndrome 53.27 12.06 10 138896 39272 64320554
Varicella zoster virus infection 53.18 12.06 53 138853 3835 64355991
Blood pressure systolic increased 53.08 12.06 20 138886 49433 64310393
Post embolisation syndrome 52.93 12.06 15 138891 61 64359765
Metastases to skin 52.67 12.06 35 138871 1417 64358409
Gastrooesophageal reflux disease 52.42 12.06 61 138845 83082 64276744
Neck pain 52.30 12.06 34 138872 61499 64298327
Chloroma 52.23 12.06 27 138879 678 64359148
Pneumocystis jirovecii infection 51.77 12.06 42 138864 2319 64357507
Pneumatosis intestinalis 51.65 12.06 60 138846 5169 64354657
Diarrhoea 50.79 12.06 1178 137728 721526 63638300
Thrombotic microangiopathy 50.28 12.06 111 138795 16544 64343282
Escherichia bacteraemia 50.06 12.06 60 138846 5343 64354483
Palpitations 49.91 12.06 93 138813 104395 64255431
Ileus paralytic 49.66 12.06 75 138831 8340 64351486
Ovarian failure 49.61 12.06 24 138882 521 64359305
Device related infection 49.56 12.06 162 138744 30464 64329362
Drug withdrawal syndrome 49.40 12.06 5 138901 31286 64328540
Abnormal behaviour 49.07 12.06 7 138899 33615 64326211
Toxic cardiomyopathy 48.83 12.06 21 138885 343 64359483
Unevaluable event 48.50 12.06 24 138882 50465 64309361
Pericardial effusion 48.44 12.06 190 138716 39064 64320762
Rash pruritic 48.41 12.06 32 138874 57372 64302454
Dyspnoea 48.12 12.06 1180 137726 717494 63642332
Drug clearance decreased 47.97 12.06 42 138864 2577 64357249
Joint stiffness 47.63 12.06 5 138901 30399 64329427
Toxic erythema of chemotherapy 47.02 12.06 18 138888 214 64359612
Philadelphia chromosome positive 46.78 12.06 24 138882 593 64359233
Gastrosplenic fistula 46.27 12.06 14 138892 75 64359751
Pneumonia klebsiella 46.17 12.06 50 138856 3987 64355839
Road traffic accident 45.82 12.06 6 138900 30739 64329087
Hyperkalaemia 45.71 12.06 93 138813 101036 64258790
Escherichia infection 45.69 12.06 101 138805 15067 64344759
Ventricular hypokinesia 45.50 12.06 69 138837 7700 64352126
Oedema peripheral 45.49 12.06 266 138640 210051 64149775
Pseudomonas infection 45.03 12.06 111 138795 17772 64342054
Enterococcal infection 44.82 12.06 95 138811 13771 64346055
Impaired healing 44.24 12.06 39 138867 60434 64299392
Ileus 44.15 12.06 129 138777 22837 64336989
Blood stem cell transplant failure 44.04 12.06 22 138884 513 64359313
Product prescribing error 43.72 12.06 11 138895 35258 64324568
Sopor 43.70 12.06 6 138900 29655 64330171
Lower respiratory tract infection 43.63 12.06 86 138820 94528 64265298
Product use issue 43.49 12.06 509 138397 151206 64208620
Vision blurred 43.48 12.06 80 138826 90236 64269590
Blister 43.33 12.06 67 138839 80900 64278926
Surgery 43.28 12.06 5 138901 28208 64331618
Toxicity to various agents 43.28 12.06 538 138368 362975 63996851
Blood lactate dehydrogenase increased 43.19 12.06 163 138743 32915 64326911
Acute myelomonocytic leukaemia 43.13 12.06 18 138888 272 64359554
Adverse drug reaction 43.09 12.06 22 138884 45442 64314384
Myelitis 43.00 12.06 36 138870 2078 64357748
Cataract 42.66 12.06 29 138877 51233 64308593
Epstein-Barr virus associated lymphoma 42.58 12.06 26 138880 907 64358919
Accidental overdose 42.51 12.06 10 138896 33547 64326279
Hepatotoxicity 41.91 12.06 184 138722 39778 64320048
White blood cell count abnormal 41.88 12.06 52 138854 4802 64355024
Colony stimulating factor therapy 41.87 12.06 21 138885 494 64359332
Heart rate irregular 41.70 12.06 5 138901 27408 64332418
Infection 41.51 12.06 593 138313 184287 64175539
Treatment noncompliance 41.27 12.06 21 138885 43461 64316365
Swollen tongue 41.26 12.06 12 138894 34942 64324884
Blood pressure decreased 40.92 12.06 77 138829 86122 64273704
Intertrigo 40.91 12.06 22 138884 600 64359226
Flagellate dermatitis 40.79 12.06 16 138890 204 64359622
Perineal necrosis 40.74 12.06 14 138892 119 64359707
Alveolar soft part sarcoma 40.52 12.06 13 138893 87 64359739
Atelectasis 40.38 12.06 140 138766 27126 64332700
Liver function test abnormal 40.30 12.06 41 138865 59360 64300466
C-reactive protein abnormal 40.24 12.06 7 138899 29040 64330786
Clonal evolution 40.23 12.06 16 138890 212 64359614
Staphylococcal sepsis 40.11 12.06 87 138819 12812 64347014
Lymphadenitis 40.04 12.06 45 138861 3740 64356086
Swelling face 39.96 12.06 41 138865 59125 64300701
Lymphoma 39.95 12.06 91 138815 13850 64345976
Refractory cancer 39.70 12.06 16 138890 220 64359606
Emotional distress 39.65 12.06 14 138892 36024 64323802
Amnesia 39.25 12.06 28 138878 48241 64311585
Gastric perforation 39.19 12.06 43 138863 3480 64356346
Withdrawal syndrome 39.13 12.06 3 138903 23489 64336337
Hypoxia 39.10 12.06 324 138582 87825 64272001
Clostridium difficile infection 39.07 12.06 168 138738 35995 64323831
Visual impairment 38.97 12.06 62 138844 74015 64285811
Osteosarcoma metastatic 38.77 12.06 11 138895 45 64359781
Peripheral sensorimotor neuropathy 38.65 12.06 37 138869 2548 64357278
Hepatitis E 38.65 12.06 36 138870 2395 64357431
Endocarditis noninfective 38.54 12.06 15 138891 187 64359639
B-cell lymphoma refractory 38.52 12.06 13 138893 104 64359722
Cutaneous calcification 38.41 12.06 13 138893 105 64359721
Cytomegalovirus viraemia 38.31 12.06 77 138829 10751 64349075
Escherichia sepsis 38.28 12.06 61 138845 7104 64352722
Gastritis bacterial 38.24 12.06 17 138889 302 64359524
Subdural hygroma 38.19 12.06 19 138887 439 64359387
Osteosarcoma recurrent 38.14 12.06 10 138896 28 64359798
Ganglioneuroblastoma 38.14 12.06 10 138896 28 64359798
Gastrointestinal fungal infection 38.10 12.06 18 138888 370 64359456
Gastric stenosis 38.09 12.06 13 138893 108 64359718
West Nile viral infection 37.92 12.06 24 138882 893 64358933
Cytomegalovirus infection reactivation 37.87 12.06 54 138852 5702 64354124
Chemotherapy 37.76 12.06 29 138877 1478 64358348
Electrocardiogram QT prolonged 37.69 12.06 71 138835 79377 64280449
Haematopoietic stem cell mobilisation 37.57 12.06 15 138891 201 64359625
Head injury 37.45 12.06 12 138894 32830 64326996
Sleep disorder 37.43 12.06 44 138862 59665 64300161
Nervousness 37.06 12.06 9 138897 29547 64330279
Ototoxicity 37.02 12.06 37 138869 2686 64357140
Therapy cessation 36.82 12.06 12 138894 32477 64327349
Autoimmune neutropenia 36.82 12.06 18 138888 400 64359426
Transient ischaemic attack 36.75 12.06 25 138881 44157 64315669
Lactic acidosis 36.66 12.06 47 138859 61363 64298463
Restlessness 36.60 12.06 20 138886 39765 64320061
Gait inability 36.57 12.06 23 138883 42345 64317481
Cerebral venous sinus thrombosis 36.52 12.06 31 138875 1824 64358002
Primary cardiac lymphoma 36.44 12.06 9 138897 18 64359808
Metastases to spine 36.31 12.06 42 138864 3601 64356225
Capillary leak syndrome 36.25 12.06 40 138866 3257 64356569
Clostridium difficile colitis 36.25 12.06 135 138771 27088 64332738
Renal tubular disorder 36.24 12.06 54 138852 5933 64353893
Irritability 36.01 12.06 17 138889 36729 64323097
Nail pigmentation 35.90 12.06 16 138890 286 64359540
Weight decreased 35.85 12.06 418 138488 285321 64074505
Mucormycosis 35.84 12.06 60 138846 7281 64352545
Lip swelling 35.79 12.06 12 138894 31895 64327931
Metastases to retroperitoneum 35.69 12.06 17 138889 356 64359470
Hydrothorax 35.53 12.06 26 138880 1231 64358595
Glioma 35.24 12.06 19 138887 521 64359305
Alopecia 35.05 12.06 211 138695 165479 64194347
Depressed level of consciousness 35.03 12.06 77 138829 81359 64278467
Strongyloidiasis 34.86 12.06 38 138868 3052 64356774
Pseudomonal sepsis 34.73 12.06 49 138857 5123 64354703
Blast cells present 34.63 12.06 22 138884 824 64359002
Depressed mood 34.39 12.06 23 138883 40989 64318837
Necrotising gastritis 34.37 12.06 11 138895 73 64359753
Helicobacter infection 34.26 12.06 20 138886 38342 64321484
Amniotic fluid index decreased 34.25 12.06 8 138898 11 64359815
Alveolitis 34.21 12.06 41 138865 3651 64356175
Invasive ductal breast carcinoma 34.20 12.06 48 138858 4994 64354832
Hypertriglyceridaemia 34.19 12.06 75 138831 11130 64348696
Fanconi syndrome 34.04 12.06 34 138872 2467 64357359
Faeces discoloured 33.94 12.06 7 138899 25722 64334104
Labelled drug-drug interaction medication error 33.62 12.06 4 138902 22058 64337768
Haemorrhage 33.34 12.06 76 138830 79275 64280551
Clostridium bacteraemia 33.31 12.06 15 138891 275 64359551
COVID-19 pneumonia 32.97 12.06 94 138812 16410 64343416
Therapy non-responder 32.95 12.06 249 138657 65650 64294176
Organising pneumonia 32.76 12.06 65 138841 8990 64350836
B-cell lymphoma 32.72 12.06 49 138857 5408 64354418
Autoimmune lymphoproliferative syndrome 32.71 12.06 13 138893 172 64359654
Plasma cell myeloma recurrent 32.62 12.06 42 138864 4023 64355803
Bursitis 32.48 12.06 4 138902 21481 64338345
Haematoma 32.44 12.06 31 138875 46219 64313607
Pneumothorax spontaneous 32.30 12.06 23 138883 1043 64358783
Hypoaesthesia 32.20 12.06 172 138734 138936 64220890
Urinary tract infection 32.15 12.06 331 138575 231265 64128561
Squamous cell carcinoma of the oral cavity 31.94 12.06 17 138889 454 64359372
Limb injury 31.83 12.06 6 138900 23499 64336327
Product administration error 31.70 12.06 10 138896 27633 64332193
Influenza 31.70 12.06 120 138786 106411 64253415
Secondary immunodeficiency 31.61 12.06 34 138872 2690 64357136
Hepatitis C RNA increased 31.61 12.06 16 138890 384 64359442
Acute lung injury 31.54 12.06 34 138872 2697 64357129
Unintentional medical device removal 31.50 12.06 54 138852 6680 64353146
Large intestinal ulcer perforation 31.16 12.06 10 138896 67 64359759
Nasal abscess 31.10 12.06 12 138894 146 64359680
Dementia 31.07 12.06 4 138902 20762 64339064
Paraparesis 31.00 12.06 38 138868 3464 64356362
Back pain 30.98 12.06 367 138539 249804 64110022
Lethargy 30.93 12.06 69 138837 72525 64287301
Bone marrow infiltration 30.92 12.06 17 138889 485 64359341
Rhinorrhoea 30.79 12.06 51 138855 59918 64299908
Central nervous system enteroviral infection 30.78 12.06 10 138896 70 64359756
Vocal cord paralysis 30.74 12.06 30 138876 2116 64357710
Abdominal neoplasm 30.73 12.06 16 138890 408 64359418
Viral load increased 30.56 12.06 32 138874 2455 64357371
Hepatosplenic candidiasis 30.33 12.06 17 138889 504 64359322
Influenza like illness 30.28 12.06 54 138852 61648 64298178
Clonal haematopoiesis 30.23 12.06 7 138899 9 64359817
Therapy responder 30.14 12.06 16 138890 425 64359401
Disorientation 30.06 12.06 46 138860 55782 64304044
Hepatitis B DNA increased 29.89 12.06 18 138888 612 64359214
Premature delivery 29.78 12.06 98 138808 18491 64341335
Eosinophilia 29.78 12.06 23 138883 38053 64321773
Mesenteric abscess 29.74 12.06 11 138895 118 64359708
Anastomotic leak 29.63 12.06 21 138885 945 64358881
Ear infection 29.59 12.06 7 138899 23397 64336429
Osteomyelitis bacterial 29.47 12.06 16 138890 445 64359381
Osteosarcoma 29.45 12.06 14 138892 292 64359534
Bone lesion 29.20 12.06 45 138861 5092 64354734
Abortion spontaneous 29.01 12.06 9 138897 25134 64334692
Metastases to bone marrow 28.92 12.06 18 138888 650 64359176
Meningitis cryptococcal 28.84 12.06 34 138872 2975 64356851
Metastases to pleura 28.81 12.06 23 138883 1241 64358585
Leukoerythroblastosis 28.73 12.06 13 138893 241 64359585
VIth nerve paresis 28.72 12.06 11 138895 131 64359695
Dry mouth 28.65 12.06 54 138852 60364 64299462
Unresponsive to stimuli 28.62 12.06 40 138866 50353 64309473
Metastases to spleen 28.08 12.06 16 138890 490 64359336
Cholelithiasis 28.02 12.06 34 138872 45472 64314354
Migraine 28.01 12.06 58 138848 62619 64297207
Left ventricular dilatation 27.99 12.06 20 138886 912 64358914
Ovarian cancer recurrent 27.70 12.06 14 138892 335 64359491
Chemotherapeutic drug level increased 27.58 12.06 14 138892 338 64359488
Perineal infection 27.55 12.06 14 138892 339 64359487
Product quality issue 27.38 12.06 15 138891 29784 64330042
Adrenocortical carcinoma 27.35 12.06 9 138897 66 64359760
Metastases to meninges 27.30 12.06 32 138874 2783 64357043
Respiratory syncytial virus infection 27.30 12.06 53 138853 7215 64352611
Neutropenic infection 27.27 12.06 27 138879 1938 64357888
T-cell type acute leukaemia 27.18 12.06 11 138895 153 64359673
Oesophageal candidiasis 27.16 12.06 56 138850 7961 64351865
Muscle rigidity 27.05 12.06 3 138903 17470 64342356
Mood swings 27.04 12.06 3 138903 17465 64342361
Rhinovirus infection 27.02 12.06 48 138858 6108 64353718
Enterococcal sepsis 26.98 12.06 30 138876 2464 64357362
Chronic myelomonocytic leukaemia 26.90 12.06 18 138888 737 64359089
Nodular regenerative hyperplasia 26.89 12.06 19 138887 851 64358975
Vena cava thrombosis 26.80 12.06 30 138876 2482 64357344
Dry skin 26.74 12.06 43 138863 51118 64308708
Burning sensation 26.66 12.06 41 138865 49623 64310203
Recall phenomenon 26.62 12.06 20 138886 986 64358840
Myasthenia gravis crisis 26.62 12.06 19 138887 865 64358961
Throat irritation 26.56 12.06 19 138887 32692 64327134
Localised infection 26.55 12.06 16 138890 30145 64329681
Extrapyramidal disorder 26.46 12.06 5 138901 19547 64340279
Stem cell transplant 26.43 12.06 35 138871 3446 64356380
Gastric disorder 26.39 12.06 15 138891 29182 64330644
Bacterial sepsis 26.35 12.06 53 138853 7404 64352422
Eye pain 26.16 12.06 18 138888 31607 64328219
Metastases to soft tissue 26.16 12.06 14 138892 378 64359448
Flatulence 26.09 12.06 23 138883 35643 64324183
Intussusception 26.07 12.06 19 138887 894 64358932
Joint range of motion decreased 26.06 12.06 5 138901 19338 64340488
Type 2 diabetes mellitus 26.04 12.06 21 138885 33999 64325827
Photosensitivity reaction 26.02 12.06 4 138902 18169 64341657
Fungal oesophagitis 25.98 12.06 18 138888 781 64359045
Thyroid dermatopathy 25.86 12.06 7 138899 23 64359803
Eczema 25.83 12.06 16 138890 29704 64330122
Mass 25.80 12.06 82 138824 15194 64344632
Diabetes mellitus inadequate control 25.76 12.06 7 138899 21314 64338512
Heart rate abnormal 25.72 12.06 42 138864 4993 64354833
Biliary-bronchial fistula 25.71 12.06 5 138901 0 64359826
Orthostatic hypotension 25.65 12.06 38 138868 46700 64313126
Oxygen saturation decreased 25.65 12.06 131 138775 107045 64252781
Leukaemic lymphoma 25.64 12.06 9 138897 82 64359744
Red blood cell sedimentation rate increased 25.55 12.06 18 138888 31217 64328609
Carotid intima-media thickness increased 25.45 12.06 9 138897 84 64359742
Crying 25.42 12.06 6 138900 20084 64339742
Body dysmorphic disorder 25.38 12.06 12 138894 247 64359579
Pericarditis 25.36 12.06 61 138845 62455 64297371
Therapy interrupted 25.32 12.06 6 138900 20030 64339796
Subclavian vein thrombosis 25.32 12.06 28 138878 2286 64357540
Vertigo 25.21 12.06 56 138850 58955 64300871
Leukoencephalopathy 25.19 12.06 50 138856 6917 64352909
Acute biphenotypic leukaemia 25.18 12.06 10 138896 132 64359694
Lymphocytosis 25.18 12.06 35 138871 3609 64356217
Nightmare 25.16 12.06 7 138899 20986 64338840
Iron deficiency anaemia 24.96 12.06 8 138898 21881 64337945
Amenorrhoea 24.95 12.06 48 138858 6491 64353335
Meningitis tuberculous 24.86 12.06 20 138886 1091 64358735
Adverse event 24.86 12.06 29 138877 39460 64320366
Cardiac dysfunction 24.78 12.06 32 138874 3074 64356752
Tumour necrosis 24.68 12.06 24 138882 1685 64358141
Diabetic ketoacidosis 24.67 12.06 17 138889 29828 64329998
Ovarian epithelial cancer recurrent 24.63 12.06 6 138900 11 64359815
Rectal haemorrhage 24.54 12.06 61 138845 61756 64298070
Venous thrombosis 24.54 12.06 47 138859 6334 64353492
Pyomyositis 24.52 12.06 15 138891 525 64359301
Skin mass 24.51 12.06 50 138856 7056 64352770
Respiratory tract congestion 24.46 12.06 3 138903 16162 64343664
Infusion site streaking 24.44 12.06 14 138892 433 64359393
Cutaneous T-cell lymphoma recurrent 24.39 12.06 8 138898 58 64359768
Hip fracture 24.38 12.06 14 138892 27085 64332741
Glioblastoma multiforme 24.35 12.06 20 138886 1124 64358702
Respiratory depression 24.30 12.06 10 138896 23433 64336393
Computerised tomogram thorax 24.27 12.06 10 138896 146 64359680
Blood urine present 24.17 12.06 5 138901 18335 64341491
Device related thrombosis 24.15 12.06 26 138880 2059 64357767
Blood potassium increased 23.98 12.06 13 138893 25967 64333859
Coma 23.97 12.06 102 138804 87513 64272313
Eye swelling 23.93 12.06 9 138897 22272 64337554
Marginal zone lymphoma recurrent 23.87 12.06 7 138899 33 64359793
Gallbladder disorder 23.82 12.06 4 138902 17026 64342800
Combined immunodeficiency 23.82 12.06 9 138897 103 64359723
B precursor type acute leukaemia 23.75 12.06 12 138894 287 64359539
Haematochezia 23.71 12.06 69 138837 66304 64293522
Intestinal atresia 23.70 12.06 8 138898 64 64359762
T-cell lymphoma 23.57 12.06 20 138886 1176 64358650
Respiratory distress 23.55 12.06 193 138713 52138 64307688
Hypertension 23.39 12.06 405 138501 258856 64100970
Oedema 23.37 12.06 110 138796 91825 64268001
Epstein Barr virus positive mucocutaneous ulcer 23.36 12.06 16 138890 681 64359145
Renal disorder 23.32 12.06 25 138881 35340 64324486
Sarcoidosis 23.31 12.06 45 138861 6101 64353725
Panic attack 23.29 12.06 8 138898 20945 64338881
Sarcoma metastatic 23.28 12.06 8 138898 68 64359758
Kidney infection 23.23 12.06 5 138901 17833 64341993
Poisoning 23.23 12.06 9 138897 21870 64337956
Blood urea increased 23.18 12.06 37 138869 44116 64315710
Retinal haemorrhage 23.12 12.06 50 138856 7348 64352478
Acute respiratory distress syndrome 22.88 12.06 153 138753 38782 64321044
Acute hepatic failure 22.81 12.06 114 138792 25998 64333828
Ankle brachial index decreased 22.78 12.06 8 138898 73 64359753
Gastrointestinal haemorrhage 22.77 12.06 179 138727 132133 64227693
Disorder of orbit 22.72 12.06 9 138897 118 64359708
Listeria sepsis 22.60 12.06 15 138891 606 64359220
Pulse waveform abnormal 22.59 12.06 8 138898 75 64359751
Tooth disorder 22.51 12.06 10 138896 22392 64337434
Abdominal abscess 22.51 12.06 45 138861 6259 64353567
Blood creatinine increased 22.31 12.06 186 138720 135596 64224230
Hyperferritinaemia 22.26 12.06 14 138892 515 64359311
Cerebral haemangioma 22.18 12.06 9 138897 126 64359700
Herpes simplex encephalitis 22.17 12.06 15 138891 626 64359200
Tendonitis 22.11 12.06 8 138898 20274 64339552
Mucosal disorder 22.05 12.06 30 138876 3032 64356794
Disseminated intravascular coagulation 22.04 12.06 132 138774 32216 64327610
Colitis ulcerative 22.03 12.06 11 138895 23017 64336809
Fear 21.91 12.06 8 138898 20163 64339663
Acute monocytic leukaemia 21.91 12.06 13 138893 430 64359396
Refractory cytopenia with multilineage dysplasia 21.88 12.06 11 138895 260 64359566
Pleuroparenchymal fibroelastosis 21.88 12.06 6 138900 21 64359805
Cardiac arrest 21.86 12.06 219 138687 153845 64205981
Blood HIV RNA increased 21.73 12.06 21 138885 1463 64358363
Klebsiella bacteraemia 21.70 12.06 26 138880 2314 64357512
Medication error 21.69 12.06 47 138859 49919 64309907
Lentigo 21.67 12.06 13 138893 439 64359387
Vascular injury 21.62 12.06 18 138888 1031 64358795
Mediastinum neoplasm 21.62 12.06 8 138898 86 64359740
Fungal infection 21.60 12.06 137 138769 34114 64325712
B-cell type acute leukaemia 21.56 12.06 13 138893 443 64359383
Geotrichum infection 21.56 12.06 17 138889 901 64358925
Hallucination, auditory 21.55 12.06 5 138901 16934 64342892
Cellulitis gangrenous 21.54 12.06 11 138895 269 64359557
Hyperpyrexia 21.53 12.06 39 138867 5038 64354788
Feeling hot 21.48 12.06 41 138865 45622 64314204
Dysgeusia 21.48 12.06 43 138863 47004 64312822
Neoplasm 21.38 12.06 47 138859 6984 64352842
Pulmonary embolism 21.36 12.06 438 138468 145918 64213908
Injection site rash 21.36 12.06 4 138902 15738 64344088
Hot flush 21.33 12.06 42 138864 46193 64313633
Fungaemia 21.30 12.06 33 138873 3752 64356074
Rhabdomyosarcoma 21.21 12.06 9 138897 142 64359684
Duodenal stenosis 21.21 12.06 15 138891 673 64359153
Taeniasis 21.19 12.06 7 138899 52 64359774
Gastroenteritis viral 21.14 12.06 8 138898 19721 64340105
Body temperature decreased 21.13 12.06 15 138891 25913 64333913
Leukaemia recurrent 21.13 12.06 27 138879 2567 64357259
Hypersomnia 21.11 12.06 8 138898 19709 64340117
Encephalitis enteroviral 21.10 12.06 9 138897 144 64359682
Respiratory tract infection fungal 20.99 12.06 18 138888 1074 64358752
Vulvovaginal inflammation 20.95 12.06 13 138893 467 64359359
Procedural pain 20.91 12.06 4 138902 15504 64344322
Quadriplegia 20.91 12.06 29 138877 2984 64356842
Rhabdomyosarcoma recurrent 20.91 12.06 8 138898 95 64359731
Mucoepidermoid carcinoma of salivary gland 20.83 12.06 8 138898 96 64359730
Toxic encephalopathy 20.69 12.06 57 138849 9758 64350068
Trichodysplasia spinulosa 20.67 12.06 15 138891 701 64359125
Erythropenia 20.61 12.06 12 138894 383 64359443
Pneumonia cytomegaloviral 20.57 12.06 35 138871 4304 64355522
Delirium 20.54 12.06 78 138828 69116 64290710
Device dislocation 20.44 12.06 10 138896 21168 64338658
Sneezing 20.43 12.06 4 138902 15247 64344579
Metabolic acidosis 20.42 12.06 81 138825 70877 64288949
Transformation to acute myeloid leukaemia 20.34 12.06 16 138890 845 64358981
Immunosuppression 20.31 12.06 60 138846 10686 64349140
Hormone receptor positive breast cancer 20.23 12.06 11 138895 307 64359519
COVID-19 20.21 12.06 222 138684 64918 64294908
Leukonychia 20.17 12.06 6 138900 30 64359796
Myelitis transverse 20.15 12.06 21 138885 1602 64358224
Enterovirus test positive 20.14 12.06 10 138896 230 64359596
Mental status changes 20.13 12.06 66 138840 61096 64298730
Human rhinovirus test positive 20.03 12.06 12 138894 404 64359422
Coronary artery occlusion 20.02 12.06 3 138903 13888 64345938
Therapeutic response delayed 20.00 12.06 16 138890 866 64358960
Metastases to muscle 19.97 12.06 11 138895 315 64359511
Periorbital cellulitis 19.94 12.06 15 138891 741 64359085
Pyloric stenosis 19.90 12.06 12 138894 409 64359417
Ageusia 19.87 12.06 3 138903 13810 64346016
Neuroborreliosis 19.85 12.06 8 138898 110 64359716
Glycosylated haemoglobin increased 19.85 12.06 5 138901 16014 64343812
Dry eye 19.72 12.06 20 138886 28999 64330827
Upper limb fracture 19.70 12.06 4 138902 14862 64344964
Primary immunodeficiency syndrome 19.64 12.06 7 138899 67 64359759
Stevens-Johnson syndrome 19.63 12.06 27 138879 34222 64325604
Sinus disorder 19.60 12.06 6 138900 16902 64342924
Metastases to pelvis 19.59 12.06 13 138893 525 64359301
Sputum discoloured 19.53 12.06 7 138899 17849 64341977
Laboratory test abnormal 19.51 12.06 14 138892 24049 64335777
Uterine enlargement 19.50 12.06 15 138891 766 64359060
Pneumonia aspiration 19.48 12.06 64 138842 59207 64300619
Abdominal mass 19.42 12.06 28 138878 2987 64356839
Cardiogenic shock 19.40 12.06 128 138778 32299 64327527
Blood pressure diastolic decreased 19.39 12.06 12 138894 22289 64337537
Aplastic anaemia 19.35 12.06 70 138836 13850 64345976
Superior vena cava syndrome 19.21 12.06 17 138889 1058 64358768
Cerebellar haemangioma 19.19 12.06 7 138899 72 64359754
Embolism 19.15 12.06 64 138842 12171 64347655
Amputation stump pain 19.12 12.06 6 138900 37 64359789
Jejunal stenosis 19.10 12.06 7 138899 73 64359753
Oral fungal infection 19.09 12.06 28 138878 3033 64356793
Cerebellar stroke 19.09 12.06 12 138894 441 64359385
Folliculitis 19.02 12.06 22 138884 30055 64329771
Sinus polyp 19.02 12.06 12 138894 444 64359382
Hepatic infarction 18.95 12.06 15 138891 799 64359027
Splenic candidiasis 18.94 12.06 7 138899 75 64359751
Sciatica 18.91 12.06 10 138896 20254 64339572
Movement disorder 18.91 12.06 12 138894 21988 64337838
Creatinine renal clearance decreased 18.86 12.06 4 138902 14417 64345409
Transaminases 18.85 12.06 7 138899 76 64359750
Angina unstable 18.83 12.06 5 138901 15462 64344364
Hyperbilirubinaemia 18.82 12.06 93 138813 21112 64338714
Skin laceration 18.77 12.06 15 138891 24402 64335424
Transplant rejection 18.73 12.06 7 138899 17394 64342432
Sleep apnoea syndrome 18.68 12.06 22 138884 29810 64330016
Positron emission tomogram abnormal 18.62 12.06 10 138896 272 64359554
Vulvovaginitis 18.55 12.06 10 138896 274 64359552
Cardiac failure acute 18.48 12.06 77 138829 16267 64343559
Pregnancy 18.46 12.06 11 138895 20854 64338972
Tissue infiltration 18.44 12.06 13 138893 580 64359246
Cutaneous T-cell lymphoma 18.40 12.06 24 138882 2328 64357498
Gastrointestinal inflammation 18.37 12.06 41 138865 6154 64353672
Enterovirus infection 18.36 12.06 19 138887 1438 64358388
Neurofibrosarcoma 18.25 12.06 9 138897 204 64359622
Haemoptysis 18.25 12.06 50 138856 48998 64310828
Dysaesthesia 18.25 12.06 36 138870 4959 64354867
Paranasal sinus mucosal hypertrophy 18.23 12.06 7 138899 84 64359742
Pathogen resistance 18.22 12.06 64 138842 12479 64347347
Bicytopenia 18.21 12.06 30 138876 3592 64356234
Liver function test increased 18.17 12.06 24 138882 30946 64328880
Premature ageing 18.08 12.06 7 138899 86 64359740
Leukaemia cutis 18.05 12.06 8 138898 141 64359685
Pulmonary alveolar haemorrhage 18.05 12.06 54 138852 9684 64350142
Blood glucose decreased 18.04 12.06 14 138892 23109 64336717
Therapeutic response unexpected 18.04 12.06 7 138899 16994 64342832
Radiation skin injury 17.95 12.06 18 138888 1312 64358514
Clostridium test positive 17.95 12.06 32 138874 4083 64355743
Hypersensitivity pneumonitis 17.94 12.06 28 138878 3204 64356622
Osteoporosis 17.92 12.06 40 138866 42040 64317786
Bladder perforation 17.92 12.06 10 138896 294 64359532
Blood loss anaemia 17.87 12.06 4 138902 13888 64345938
Chromosome analysis abnormal 17.82 12.06 9 138897 215 64359611
Hepatosplenomegaly 17.72 12.06 37 138869 5306 64354520
Hepatic amoebiasis 17.72 12.06 7 138899 91 64359735
Thrombocytopenia neonatal 17.71 12.06 5 138901 20 64359806
Basal ganglion degeneration 17.68 12.06 11 138895 397 64359429
Secondary cerebellar degeneration 17.67 12.06 6 138900 49 64359777
Pneumonia salmonella 17.67 12.06 6 138900 49 64359777
Evans syndrome 17.65 12.06 11 138895 398 64359428
Salivary gland neoplasm 17.65 12.06 7 138899 92 64359734
Spindle cell sarcoma 17.63 12.06 9 138897 220 64359606
Disturbance in attention 17.53 12.06 39 138867 41035 64318791
Gastric pneumatosis 17.52 12.06 5 138901 21 64359805
Helicobacter sepsis 17.52 12.06 5 138901 21 64359805
Anger 17.51 12.06 6 138900 15735 64344091
Pulmonary vein stenosis 17.50 12.06 8 138898 152 64359674
Pseudocirrhosis 17.46 12.06 13 138893 632 64359194
Hypertransaminasaemia 17.44 12.06 44 138862 7147 64352679
Candida endophthalmitis 17.36 12.06 8 138898 155 64359671
Papillary thyroid cancer 17.29 12.06 23 138883 2275 64357551
Disseminated cytomegaloviral infection 17.27 12.06 11 138895 414 64359412
Pulmonary hypoplasia 17.26 12.06 6 138900 53 64359773
Splenic necrosis 17.19 12.06 7 138899 99 64359727
Poor venous access 17.18 12.06 3 138903 12414 64347412
Ocular hyperaemia 17.18 12.06 14 138892 22550 64337276
Hernia 17.18 12.06 4 138902 13514 64346312
Acute pulmonary histoplasmosis 17.16 12.06 9 138897 233 64359593
Splenic marginal zone lymphoma 17.15 12.06 5 138901 23 64359803
Frequent bowel movements 17.13 12.06 9 138897 18296 64341530
Toxic neuropathy 17.12 12.06 14 138892 782 64359044
Radiation necrosis 17.10 12.06 10 138896 322 64359504
Pharyngeal inflammation 17.08 12.06 15 138891 924 64358902
Bacterial translocation 17.08 12.06 11 138895 422 64359404
Sphingomonas paucimobilis infection 17.06 12.06 7 138899 101 64359725
Rash erythematous 17.05 12.06 51 138855 48582 64311244
Hypertensive crisis 17.04 12.06 9 138897 18239 64341587
Diverticulitis 17.03 12.06 36 138870 38582 64321244
Dysarthria 16.97 12.06 68 138838 59338 64300488
Synovial sarcoma 16.97 12.06 6 138900 56 64359770
Urinary retention 16.96 12.06 52 138854 49149 64310677
Photophobia 16.94 12.06 8 138898 17285 64342541
Plasma cell myeloma refractory 16.94 12.06 7 138899 103 64359723
Ventricular dysfunction 16.91 12.06 36 138870 5234 64354592
Peritonitis viral 16.87 12.06 6 138900 57 64359769
Hypercholesterolaemia 16.86 12.06 6 138900 15367 64344459
Abdominal wound dehiscence 16.85 12.06 9 138897 242 64359584
Chronic hepatitis 16.82 12.06 17 138889 1251 64358575
Mucosal infection 16.80 12.06 11 138895 434 64359392
Hepatic fibrosis 16.76 12.06 37 138869 5515 64354311
Guillain-Barre syndrome 16.75 12.06 45 138861 7590 64352236
Systolic dysfunction 16.75 12.06 27 138879 3175 64356651
Campylobacter gastroenteritis 16.74 12.06 16 138890 1100 64358726
Blood potassium decreased 16.72 12.06 39 138867 40360 64319466
Miosis 16.71 12.06 4 138902 13262 64346564
Prescribed underdose 16.65 12.06 9 138897 18006 64341820
Rotator cuff syndrome 16.59 12.06 3 138903 12104 64347722
Pulmonary artery stenosis 16.58 12.06 7 138899 109 64359717
Molluscum contagiosum 16.52 12.06 11 138895 447 64359379
Squamous cell carcinoma of head and neck 16.46 12.06 9 138897 254 64359572
Gingivitis ulcerative 16.46 12.06 9 138897 254 64359572
Streptococcal infection 16.33 12.06 44 138862 7435 64352391
Dyskinesia 16.32 12.06 38 138868 39350 64320476
Humoral immune defect 16.30 12.06 7 138899 114 64359712
Candida pneumonia 16.28 12.06 11 138895 458 64359368
Blood pressure diastolic abnormal 16.23 12.06 3 138903 11914 64347912
Ecchymosis 16.21 12.06 5 138901 14017 64345809
Granulomatous pneumonitis 16.17 12.06 6 138900 65 64359761
Suspected product quality issue 16.11 12.06 9 138897 265 64359561
Pneumaturia 16.05 12.06 5 138901 30 64359796
Spinal stenosis 16.05 12.06 5 138901 13926 64345900
Opsoclonus myoclonus 16.04 12.06 8 138898 186 64359640
Human polyomavirus infection 16.03 12.06 15 138891 1004 64358822
Chronic lymphocytic leukaemia refractory 16.02 12.06 7 138899 119 64359707
Cerebral aspergillosis 16.01 12.06 19 138887 1674 64358152
Metastases to abdominal wall 15.97 12.06 7 138899 120 64359706
Mucoepidermoid carcinoma 15.93 12.06 6 138900 68 64359758
Epstein-Barr virus associated lymphoproliferative disorder 15.91 12.06 26 138880 3093 64356733
Haemoglobin abnormal 15.90 12.06 38 138868 5966 64353860
Wound evisceration 15.87 12.06 7 138899 122 64359704
Grip strength decreased 15.86 12.06 3 138903 11721 64348105
Tidal volume decreased 15.85 12.06 6 138900 69 64359757
Blood calcium decreased 15.83 12.06 19 138887 25535 64334291
Splenic lesion 15.83 12.06 10 138896 371 64359455
Myeloproliferative neoplasm 15.77 12.06 14 138892 875 64358951
Bone marrow necrosis 15.77 12.06 8 138898 193 64359633
Pneumoperitoneum 15.77 12.06 24 138882 2687 64357139
Femur fracture 15.75 12.06 31 138875 34104 64325722
Respiratory rate increased 15.75 12.06 10 138896 18321 64341505
Lung adenocarcinoma 15.73 12.06 41 138865 6792 64353034
Extramedullary haemopoiesis 15.71 12.06 7 138899 125 64359701
BRCA2 gene mutation 15.70 12.06 6 138900 71 64359755
Primary mediastinal large B-cell lymphoma recurrent 15.70 12.06 6 138900 71 64359755
Ichthyosis 15.66 12.06 7 138899 126 64359700
Hepatic infection fungal 15.66 12.06 8 138898 196 64359630
Metastases to abdominal cavity 15.62 12.06 11 138895 490 64359336
Hepatitis viral 15.55 12.06 14 138892 891 64358935
Right ventricular failure 15.52 12.06 14 138892 21457 64338369
Rectal fissure 15.50 12.06 13 138893 752 64359074
Fusarium infection 15.49 12.06 18 138888 1551 64358275
Lymphadenopathy mediastinal 15.46 12.06 29 138877 3847 64355979
Platelet count abnormal 15.46 12.06 30 138876 4082 64355744
Joint ankylosis 15.44 12.06 13 138893 756 64359070
Drug level decreased 15.44 12.06 3 138903 11500 64348326
Omental infarction 15.43 12.06 3 138903 0 64359826
Meningoencephalitis viral 15.40 12.06 10 138896 389 64359437
Poor quality sleep 15.39 12.06 11 138895 18940 64340886
Glaucoma 15.36 12.06 8 138898 16340 64343486
Sinus congestion 15.35 12.06 7 138899 15432 64344394
Adenocarcinoma gastric 15.25 12.06 18 138888 1577 64358249
Acanthosis 15.24 12.06 10 138896 396 64359430
Morphoea 15.24 12.06 10 138896 396 64359430
Joint effusion 15.23 12.06 5 138901 13468 64346358
Scedosporium infection 15.17 12.06 16 138890 1238 64358588
Adenovirus infection 15.16 12.06 42 138864 7213 64352613
Mydriasis 15.13 12.06 7 138899 15305 64344521
Cancer fatigue 15.12 12.06 6 138900 79 64359747
Scar 15.09 12.06 5 138901 13393 64346433
Fracture 15.09 12.06 11 138895 18744 64341082
Metapneumovirus bronchiolitis 15.05 12.06 4 138902 12 64359814
Failure to thrive 15.04 12.06 53 138853 10351 64349475
Acute lymphocytic leukaemia refractory 15.04 12.06 7 138899 139 64359687
Right ventricular dysfunction 14.98 12.06 21 138885 2182 64357644
Inflammation 14.96 12.06 81 138825 65219 64294607
Product storage error 14.95 12.06 5 138901 13313 64346513
Torulopsis infection 14.92 12.06 5 138901 39 64359787
Scrotal abscess 14.91 12.06 10 138896 411 64359415
Azoospermia 14.90 12.06 7 138899 142 64359684
Chromaturia 14.89 12.06 16 138890 22595 64337231
Metastases to eye 14.88 12.06 8 138898 218 64359608
Angioimmunoblastic T-cell lymphoma 14.87 12.06 10 138896 413 64359413
Chest discomfort 14.87 12.06 169 138737 115937 64243889
Necrosis 14.85 12.06 45 138861 8126 64351700
Lewis-Sumner syndrome 14.81 12.06 5 138901 40 64359786
Mood altered 14.74 12.06 8 138898 15971 64343855
Pulmonary sarcoidosis 14.70 12.06 15 138891 1116 64358710
Abdominal distension 14.65 12.06 134 138772 95860 64263966
Sudden death 14.65 12.06 13 138893 20083 64339743
Ventricular internal diameter abnormal 14.64 12.06 7 138899 148 64359678
Oligohydramnios 14.54 12.06 25 138881 3099 64356727
Deafness 14.54 12.06 78 138828 18281 64341545
Triple negative breast cancer 14.54 12.06 6 138900 88 64359738
Heavy menstrual bleeding 14.52 12.06 4 138902 12073 64347753
Atypical haemolytic uraemic syndrome 14.52 12.06 12 138894 680 64359146
Pleural neoplasm 14.46 12.06 8 138898 231 64359595
Deafness bilateral 14.46 12.06 19 138887 1857 64357969
Secretion discharge 14.32 12.06 4 138902 11960 64347866
Performance status decreased 14.26 12.06 34 138872 5330 64354496
Respiratory tract infection 14.25 12.06 133 138773 37274 64322552
Large intestine polyp 14.19 12.06 3 138903 10834 64348992
Lymph node pain 14.17 12.06 16 138890 1336 64358490
Beta 2 microglobulin decreased 14.17 12.06 4 138902 16 64359810
Noctiphobia 14.17 12.06 4 138902 16 64359810
Cryptococcal fungaemia 14.14 12.06 7 138899 160 64359666
Head discomfort 14.08 12.06 4 138902 11830 64347996
Osteopenia 14.02 12.06 8 138898 15532 64344294
Metastases to vagina 13.98 12.06 4 138902 17 64359809
Synovial sarcoma metastatic 13.98 12.06 4 138902 17 64359809
Delusion 13.93 12.06 11 138895 18003 64341823
Pneumonitis chemical 13.91 12.06 9 138897 348 64359478
Enterocolitis 13.89 12.06 57 138849 11961 64347865
Disseminated cryptococcosis 13.86 12.06 17 138889 1550 64358276
Device issue 13.86 12.06 17 138889 22631 64337195
Metastatic neoplasm 13.86 12.06 30 138876 4412 64355414
Hypothalamo-pituitary disorder 13.85 12.06 14 138892 1030 64358796
Invasive breast carcinoma 13.84 12.06 10 138896 464 64359362
Small intestinal perforation 13.83 12.06 22 138884 2558 64357268
Musculoskeletal discomfort 13.82 12.06 9 138897 16268 64343558
Restless legs syndrome 13.82 12.06 10 138896 17106 64342720
Osteolysis 13.80 12.06 23 138883 2780 64357046
Deep vein thrombosis 13.80 12.06 310 138596 104872 64254954
Metastases to ovary 13.78 12.06 8 138898 254 64359572
Hyperviscosity syndrome 13.77 12.06 9 138897 354 64359472
Peripheral coldness 13.75 12.06 6 138900 13578 64346248
Encephalitis viral 13.74 12.06 21 138885 2359 64357467
Granulomatous liver disease 13.74 12.06 15 138891 1207 64358619
Rib fracture 13.73 12.06 19 138887 24019 64335807
Dyspepsia 13.65 12.06 109 138797 80203 64279623
Melaena 13.65 12.06 64 138842 53484 64306342
Acute leukaemia 13.60 12.06 17 138889 1581 64358245
Streptococcal bacteraemia 13.57 12.06 24 138882 3043 64356783
Metastases to pancreas 13.53 12.06 10 138896 481 64359345
Klebsiella sepsis 13.51 12.06 22 138884 2610 64357216
Impaired work ability 13.50 12.06 8 138898 15211 64344615
Muscular weakness 13.46 12.06 193 138713 127145 64232681
Malignant neoplasm of orbit 13.45 12.06 4 138902 20 64359806
Vascular compression 13.39 12.06 8 138898 268 64359558
Hypoglossal nerve paresis 13.37 12.06 6 138900 109 64359717
Herpes simplex reactivation 13.37 12.06 8 138898 269 64359557
Endothelial dysfunction 13.36 12.06 7 138899 181 64359645
Increased liver stiffness 13.36 12.06 3 138903 3 64359823
Eating disorder 13.33 12.06 10 138896 16795 64343031
Dermatitis allergic 13.32 12.06 8 138898 15101 64344725
Hyperlipidaemia 13.28 12.06 18 138888 22958 64336868
Herpes zoster 13.25 12.06 242 138664 78945 64280881
Rash macular 13.25 12.06 19 138887 23666 64336160
Hypophagia 13.25 12.06 137 138769 39450 64320376
Metastases to uterus 13.25 12.06 5 138901 57 64359769
Urethritis 13.22 12.06 10 138896 498 64359328
Extravasation blood 13.21 12.06 9 138897 380 64359446
Anaphylactic reaction 13.20 12.06 90 138816 68574 64291252
Cyanosis 13.17 12.06 17 138889 22138 64337688
Adenoviral haemorrhagic cystitis 13.17 12.06 10 138896 501 64359325
Eye irritation 13.15 12.06 9 138897 15847 64343979
Hypercalcaemia 13.14 12.06 114 138792 31302 64328524
Mediastinal fibrosis 13.13 12.06 4 138902 22 64359804
Cryptosporidiosis infection 13.12 12.06 11 138895 636 64359190
Post procedural complication 13.10 12.06 16 138890 21337 64338489
H1N1 influenza 13.09 12.06 20 138886 2246 64357580
Lymphoedema 13.08 12.06 49 138857 9856 64349970
Non-cirrhotic portal hypertension 13.08 12.06 9 138897 386 64359440
Hip deformity 13.08 12.06 7 138899 189 64359637
Pseudomonal bacteraemia 13.07 12.06 20 138886 2249 64357577
Blood culture positive 13.07 12.06 42 138864 7826 64352000
Mediastinal mass 13.07 12.06 10 138896 507 64359319
Mitral valve incompetence 13.04 12.06 97 138809 25441 64334385
Systemic inflammatory response syndrome 13.00 12.06 50 138856 10185 64349641
Facial paresis 12.99 12.06 31 138875 4861 64354965
Intervertebral disc degeneration 12.96 12.06 6 138900 13114 64346712
PIK3CA-activated mutation 12.93 12.06 10 138896 515 64359311
Empyema 12.89 12.06 26 138880 3639 64356187
Blood triglycerides increased 12.82 12.06 13 138893 18853 64340973
Stomatitis necrotising 12.82 12.06 7 138899 197 64359629
Dystonia 12.82 12.06 13 138893 18852 64340974
Metastases to the mediastinum 12.78 12.06 10 138896 524 64359302
Mantle cell lymphoma 12.75 12.06 14 138892 1134 64358692
Tuberculosis liver 12.73 12.06 5 138901 64 64359762
Systemic mycosis 12.72 12.06 20 138886 2303 64357523
Infected neoplasm 12.70 12.06 8 138898 295 64359531
Dysplasia 12.69 12.06 14 138892 1140 64358686
Minimal residual disease 12.64 12.06 9 138897 408 64359418
Angina pectoris 12.63 12.06 52 138854 45029 64314797
Wrist fracture 12.63 12.06 3 138903 9998 64349828
Blindness 12.62 12.06 86 138820 21933 64337893
Anaesthesia 12.60 12.06 9 138897 410 64359416
Procedural pneumothorax 12.59 12.06 5 138901 66 64359760
Drug eruption 12.59 12.06 38 138868 36098 64323728
Obstructive airways disorder 12.58 12.06 19 138887 23166 64336660
Listeria encephalitis 12.56 12.06 8 138898 301 64359525
Splenic infarction 12.54 12.06 24 138882 3233 64356593
Bone density decreased 12.54 12.06 3 138903 9949 64349877
Paraplegia 12.52 12.06 29 138877 4461 64355365
Vessel puncture site bruise 12.51 12.06 9 138897 415 64359411
Tooth fracture 12.49 12.06 3 138903 9924 64349902
Liver abscess 12.48 12.06 32 138874 5248 64354578
T-cell lymphoma recurrent 12.46 12.06 5 138901 68 64359758
Neutrophilic dermatosis 12.44 12.06 10 138896 545 64359281
Large intestine perforation 12.44 12.06 57 138849 12547 64347279
Cardiac failure congestive 12.41 12.06 202 138704 130378 64229448
Vaginal haemorrhage 12.40 12.06 14 138892 19330 64340496
Paresis 12.35 12.06 25 138881 3507 64356319
Diabetes mellitus 12.35 12.06 88 138818 66386 64293440
Tenosynovitis 12.34 12.06 5 138901 11828 64347998
Oral candidiasis 12.33 12.06 89 138817 23123 64336703
Ear pain 12.33 12.06 22 138884 25114 64334712
Acute hepatitis C 12.32 12.06 7 138899 213 64359613
Product intolerance 12.31 12.06 4 138902 28 64359798
Ligament sprain 12.31 12.06 4 138902 10848 64348978
Adult T-cell lymphoma/leukaemia 12.30 12.06 8 138898 312 64359514
Central nervous system infection 12.30 12.06 14 138892 1180 64358646
Feeling cold 12.28 12.06 20 138886 23658 64336168
B-lymphocyte count abnormal 12.26 12.06 5 138901 71 64359755
Mental disorder 12.22 12.06 24 138882 26421 64333405
Adenocarcinoma of appendix 12.20 12.06 5 138901 72 64359754
Incorrect product administration duration 12.18 12.06 3 138903 9755 64350071
Seasonal allergy 12.16 12.06 5 138901 11721 64348105
Gout 12.15 12.06 17 138889 21396 64338430
Extraskeletal myxoid chondrosarcoma 12.15 12.06 3 138903 6 64359820
Acute myocardial infarction 12.14 12.06 94 138812 69624 64290202
Parkinsonism 12.13 12.06 8 138898 14365 64345461
Malignant ascites 12.12 12.06 13 138893 1025 64358801
Device use error 12.10 12.06 36 138870 6435 64353391
Cancer in remission 12.08 12.06 4 138902 30 64359796
Selective mutism 12.07 12.06 5 138901 74 64359752
Hip arthroplasty 12.07 12.06 17 138889 21334 64338492

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01DB01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
Anthracyclines and related substances
FDA CS M0028312 Anthracyclines
FDA MoA N0000000176 Topoisomerase Inhibitors
FDA EPC N0000175414 Anthracycline Topoisomerase Inhibitor
MeSH PA D000903 Antibiotics, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
CHEBI has role CHEBI:76971 Escherichia coli metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Acute lymphoid leukemia indication 91857003 DOID:9952
Acute myeloid leukemia, disease indication 91861009
Kaposi's sarcoma indication 109385007
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Multiple myeloma indication 109989006 DOID:9538
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Burkitt's lymphoma indication 118617000
Small cell carcinoma of lung indication 254632001 DOID:5409
Carcinoma of breast indication 254838004 DOID:3459
Nephroblastoma indication 302849000 DOID:2154
Osteosarcoma of bone indication 307576001 DOID:3376
Follicular non-Hodgkin's lymphoma indication 308121000
Malignant tumor of lung indication 363358000
Malignant tumor of ovary indication 363443007 DOID:2394
Malignant tumor of thyroid gland indication 363478007 DOID:1781
Kaposi's sarcoma associated with AIDS indication 420524008
Neuroblastoma indication 432328008 DOID:769
Carcinoma of female breast indication 447782002
Soft or Connective Tissue Sarcoma indication
Invasive Bladder Malignancy indication
Metastatic Breast Carcinoma indication
Metastatic Gastric Cancer indication
Carcinoid syndrome off-label use 35868009
Ewing's sarcoma off-label use 76909002 DOID:3369
Chronic lymphoid leukemia, disease off-label use 92814006
Malignant neoplasm of liver off-label use 93870000 DOID:3571
Endometrial carcinoma off-label use 254878006 DOID:2871
Malignant tumor of head and/or neck off-label use 255056009
Primary cutaneous T-cell lymphoma off-label use 400122007
Adenocarcinoma of pancreas off-label use 700423003 DOID:4074
Pancreatic Neuroendocrine Tumor off-label use 717919005
Mycosis contraindication 3218000 DOID:1564
Bundle branch block contraindication 6374002
Hyperbilirubinemia contraindication 14783006 DOID:2741
Viral disease contraindication 34014006 DOID:934
Hyperuricemia contraindication 35885006 DOID:1920
Conduction disorder of the heart contraindication 44808001
Myocarditis contraindication 50920009 DOID:820
Heart disease contraindication 56265001 DOID:114
Hepatic failure contraindication 59927004
Heart failure contraindication 84114007 DOID:6000
Leukopenia contraindication 84828003 DOID:615
Cardiomyopathy contraindication 85898001 DOID:0050700
Bacterial infectious disease contraindication 87628006
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Atrioventricular block contraindication 233917008 DOID:0050820
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Breastfeeding (mother) contraindication 413712001
Myocardial infarction in recovery phase contraindication 418044006
Asymptomatic left ventricular systolic dysfunction contraindication 698592004
Protozoal Infection contraindication
Severe Cardiac Disease contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.85 acidic
pKa2 9.21 acidic
pKa3 9.92 acidic
pKa4 11.11 acidic
pKa5 8.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA topoisomerase 2-alpha Enzyme INHIBITOR IC50 6 CHEMBL CHEMBL
Multidrug resistance protein 1 Transporter IC50 4.01 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 5.43 DRUG MATRIX
Canalicular multispecific organic anion transporter 1 Transporter WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 6 Transporter WOMBAT-PK
Caspase-1 Enzyme IC50 4.91 DRUG MATRIX
Tyrosine-protein kinase Lck Kinase IC50 4.50 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.29 DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2 Kinase IC50 5.61 DRUG MATRIX
72 kDa type IV collagenase Enzyme IC50 5.96 CHEMBL
DNA topoisomerase 1 Enzyme IC50 4.70 CHEMBL
Telomerase reverse transcriptase Enzyme IC50 4.14 CHEMBL
DNA topoisomerase 2-beta Enzyme IC50 5.46 CHEMBL
Aurora kinase A Kinase IC50 7.40 CHEMBL
CDGSH iron-sulfur domain-containing protein 1 Unclassified Ki 5.46 CHEMBL
Ribonuclease pancreatic Enzyme IC50 4.60 CHEMBL
Arachidonate 15-lipoxygenase Enzyme IC50 4.87 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 4.81 DRUG MATRIX
Integrase Enzyme IC50 6.05 CHEMBL
Reverse transcriptase/RNaseH Enzyme IC50 4.28 CHEMBL
Reverse transcriptase Enzyme IC50 4.28 CHEMBL
Type-2 restriction enzyme HindIII Unclassified IC50 4.02 CHEMBL
Type-2 restriction enzyme ScaI Unclassified IC50 4.60 CHEMBL
ORF 73 Unclassified AC50 5.84 CHEMBL
UDP-galactopyranose mutase Enzyme AC50 4.49 CHEMBL
5-hydroxytryptamine receptor 4 GPCR Ki 5.68 DRUG MATRIX
DNA Enzyme IC50 5.52 CHEMBL

External reference:

IDSource
4019737 VUID
N0000147829 NUI
D01275 KEGG_DRUG
25316-40-9 SECONDARY_CAS_RN
4018106 VANDF
4019737 VANDF
C0013089 UMLSCUI
CHEBI:28748 CHEBI
DM2 PDB_CHEM_ID
CHEMBL53463 ChEMBL_ID
CHEMBL359744 ChEMBL_ID
D004317 MESH_DESCRIPTOR_UI
DB00997 DRUGBANK_ID
C506643 MESH_SUPPLEMENTAL_RECORD_UI
7069 IUPHAR_LIGAND_ID
3005 INN_ID
80168379AG UNII
31703 PUBCHEM_CID
142433 RXNORM
3368 MMSL
4639 MMSL
47543 MMSL
47549 MMSL
d00218 MMSL
d04004 MMSL
002659 NDDF
004818 NDDF
372817009 SNOMEDCT_US
428681007 SNOMEDCT_US
68444001 SNOMEDCT_US
90875009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3030 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3031 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3032 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3033 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-3034 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 34 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4004 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4015 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4026 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0069-4037 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 33 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9084 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9085 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9086 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9087 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9088 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9089 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9090 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9091 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9092 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Doxorubicin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9093 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2 mg INTRAVENOUS ANDA 27 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9275 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9277 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9369 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9370 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9371 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9372 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9546 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9547 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9548 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
Adriamycin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9549 INJECTION, SOLUTION 2 mg INTRAVENOUS ANDA 26 sections
DOXIL HUMAN PRESCRIPTION DRUG LABEL 1 0338-0063 INJECTION, SUSPENSION, LIPOSOMAL 2 mg INTRAVENOUS NDA 26 sections