amrubicin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antineoplastics, daunorubicin derivatives 202 110267-81-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • SM-5887
  • amrubicin hydrochloride
  • amrubicin HCl
  • amrubicin
Amrubicin is a third-generation anthracycline and potent topoisomerase II inhibitor, for used in the treatment of small-cell lung cancer (SCLC) in Japan.
  • Molecular weight: 483.47
  • Formula: C25H25NO9
  • CLOGP: -0.03
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 5
  • TPSA: 176.61
  • ALOGS: -2.63
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,KDR,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MAPKAPK2,MAPKAPK5,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK,UHMK1,ZAP70 51
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01DB10 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
Anthracyclines and related substances
MeSH PA D000970 Antineoplastic Agents
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:156203 topoisomerase II inhibitor

Related Drugs by ATC class:

L01DB Anthracyclines and related substances 10 drugs
aclarubicindaunorubicindoxorubicinepirubicinidarubicinmitoxantronepirarubicinpixantronevalrubicinzorubicin

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.12 acidic
pKa2 9.39 acidic
pKa3 10.45 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D08854 KEGG_DRUG
110311-30-3 SECONDARY_CAS_RN
C0762659 UMLSCUI
CHEBI:135779 CHEBI
CHEMBL1186894 ChEMBL_ID
CHEMBL481958 ChEMBL_ID
DB06263 DRUGBANK_ID
C055866 MESH_SUPPLEMENTAL_RECORD_UI
6802 INN_ID
93N13LB4Z2 UNII
3035016 PUBCHEM_CID

Pharmaceutical products:

None