adiphenine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
analgesics, glafenine derivatives (subgroup of fenamic acid group) 94 64-95-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • adiphenine
  • adiphenin
  • diphacil
  • diphenylacetic acid diethylaminoethyl ester
  • tranzetil
  • trasentin
  • trasentine
  • adiphenine hydrochloride
  • adiphenine HCl
  • Molecular weight: 311.43
  • Formula: C20H25NO2
  • CLOGP: 4.53
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 29.54
  • ALOGS: -4.39
  • ROTB: 9

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.44 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Histamine H1 receptor GPCR IC50 4.77 CHEMBL
Muscarinic acetylcholine receptor GPCR Kd 7.45 CHEMBL

External reference:

IDSource
D02772 KEGG_DRUG
235433 RXNORM
C0001521 UMLSCUI
CHEBI:94680 CHEBI
CHEMBL353846 ChEMBL_ID
DB15795 DRUGBANK_ID
C084829 MESH_SUPPLEMENTAL_RECORD_UI
2031 PUBCHEM_CID
2715 INN_ID
50-42-0 SECONDARY_CAS_RN
YKG6OR043Q UNII
21394008 SNOMEDCT_US
CHEMBL555654 ChEMBL_ID
001756 NDDF
004710 NDDF

Pharmaceutical products:

None