adiphenine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
analgesics, glafenine derivatives (subgroup of fenamic acid group)	94	64-95-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

adiphenine
adiphenin
diphacil
diphenylacetic acid diethylaminoethyl ester
tranzetil
trasentin
trasentine
adiphenine hydrochloride
adiphenine HCl

Molecular weight: 311.43
Formula: C20H25NO2
CLOGP: 4.53
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 29.54
ALOGS: -4.39
ROTB: 9

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.44	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Histamine H1 receptor	GPCR		HRH1_RAT		IC50	4.77		CHEMBL
Muscarinic acetylcholine receptor	GPCR		ACM1_RAT ACM3_RAT ACM4_RAT ACM5_RAT ACM2_RAT		Kd	7.45		CHEMBL

External reference:

ID	Source
D02772	KEGG_DRUG
235433	RXNORM
C0001521	UMLSCUI
CHEBI:94680	CHEBI
CHEMBL353846	ChEMBL_ID
DB15795	DRUGBANK_ID
C084829	MESH_SUPPLEMENTAL_RECORD_UI
2031	PUBCHEM_CID
2715	INN_ID
50-42-0	SECONDARY_CAS_RN
YKG6OR043Q	UNII
21394008	SNOMEDCT_US
CHEMBL555654	ChEMBL_ID
001756	NDDF
004710	NDDF

Pharmaceutical products:

None