docarpamine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
dopaminergic agents dopamine derivatives used as cardiac stimulant/antihypertensives/diuretics 938 74639-40-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • docarpamine
  • tanadopa
a dopamine prodrug; RN given refers to (S)-isomer; structure given in first source
  • Molecular weight: 470.54
  • Formula: C21H30N2O8S
  • CLOGP: 0.05
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 2
  • TPSA: 129.26
  • ALOGS: -4.94
  • ROTB: 16

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
FDA CS M0003647 Catecholamines
FDA EPC N0000175570 Catecholamine
MeSH PA D015259 Dopamine Agents
MeSH PA D018491 Dopamine Agonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D020011 Protective Agents
MeSH PA D013566 Sympathomimetics
CHEBI has role CHEBI:35522 beta-adrenergic receptor agonist
CHEBI has role CHEBI:35524 sympathomimetic
CHEBI has role CHEBI:38147 cardiotonic drugs
CHEBI has role CHEBI:48560 dopamine agents
CHEBI has role CHEBI:75771 Mus musculus metabolite
CHEBI has role CHEBI:76971 E.coli metabolites
CHEBI has role CHEBI:77746 H. sapiens metabolites

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.85 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01903 KEGG_DRUG
4019733 VANDF
C0075755 UMLSCUI
CHEBI:31513 CHEBI
CHEBI:18243 CHEBI
CHEMBL2106351 ChEMBL_ID
C052143 MESH_SUPPLEMENTAL_RECORD_UI
6258 INN_ID
2417 INN_ID
RPQ57D8S72 UNII
71137 PUBCHEM_CID
681 PUBCHEM_CID
DB00988 DRUGBANK_ID
3628 RXNORM
6641 MMSL
d00216 MMSL
004721 NDDF
008206 NDDF
412383006 SNOMEDCT_US
59187003 SNOMEDCT_US
D004298 MESH_DESCRIPTOR_UI
C0013030 UMLSCUI

Pharmaceutical products:

None