diprafenone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antiarrhythmics, propafenone derivatives | 923 | 81447-80-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 1.20 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 11 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.50 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000889 | Anti-Arrhythmia Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.38 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Beta-1 adrenergic receptor | GPCR | WOMBAT-PK | |||||||
| Sodium channel protein type 5 subunit alpha | Ion channel | WOMBAT-PK | |||||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 86342-43-0 | SECONDARY_CAS_RN |
| C0058420 | UMLSCUI |
| CHEBI:135559 | CHEBI |
| CHEMBL441809 | ChEMBL_ID |
| C047546 | MESH_SUPPLEMENTAL_RECORD_UI |
| C037837 | MESH_SUPPLEMENTAL_RECORD_UI |
| 71249 | PUBCHEM_CID |
| 5257 | INN_ID |
| 1P35MD5C1F | UNII |
Pharmaceutical products:
None