dipivefrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| sympathomimetic, phenethyl derivatives | 922 | 52365-63-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
used in treatment of both primary & open angle glaucoma; RN given refers to (+-)-isomer
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.18 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 2, 1980 | FDA | ALLERGAN |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | S01EA02 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Sympathomimetics in glaucoma therapy |
| FDA CS | M0003647 | Catecholamines |
| FDA MoA | N0000000122 | Adrenergic Agonists |
| FDA MoA | N0000000209 | Adrenergic alpha-Agonists |
| FDA MoA | N0000000245 | Adrenergic beta-Agonists |
| FDA EPC | N0000175552 | alpha-Adrenergic Agonist |
| FDA EPC | N0000175555 | beta-Adrenergic Agonist |
| FDA EPC | N0000175570 | Catecholamine |
| CHEBI has role | CHEBI:35524 | sympathomimetic |
| CHEBI has role | CHEBI:37886 | adrenergic agonists |
| CHEBI has role | CHEBI:39456 | antiglaucoma agent |
| CHEBI has role | CHEBI:50266 | Prodrugs |
| CHEBI has role | CHEBI:66981 | ophthalmology drugs |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D000322 | Adrenergic Agonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D000316 | Adrenergic alpha-Agonists |
| MeSH PA | D000318 | Adrenergic beta-Agonists |
| MeSH PA | D018927 | Anti-Asthmatic Agents |
| MeSH PA | D001993 | Bronchodilator Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D009184 | Mydriatics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D019141 | Respiratory System Agents |
| MeSH PA | D013566 | Sympathomimetics |
| MeSH PA | D014662 | Vasoconstrictor Agents |
| FDA EPC | N0000175883 | Adrenergic Receptor Agonist |
| CHEBI has role | CHEBI:24621 | hormones |
| CHEBI has role | CHEBI:35522 | beta-adrenergic agonists |
| CHEBI has role | CHEBI:35523 | bronchodilator |
| CHEBI has role | CHEBI:35569 | alpha-adrenergic agonists |
| CHEBI has role | CHEBI:35620 | vasodilator agents |
| CHEBI has role | CHEBI:50513 | mydriatics |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Open-angle glaucoma | indication | 84494001 | DOID:1067 |
| Aphakia | contraindication | 24010005 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.72 | acidic |
| pKa2 | 8.84 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | GPCR | AGONIST | WOMBAT-PK | CHEMBL | |||||
| Alpha-2B adrenergic receptor | GPCR | AGONIST | WOMBAT-PK | CHEMBL | |||||
| Alpha-2C adrenergic receptor | GPCR | AGONIST | WOMBAT-PK | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019152 | VUID |
| N0000147397 | NUI |
| D01017 | KEGG_DRUG |
| 64019-93-8 | SECONDARY_CAS_RN |
| 203156 | RXNORM |
| 4018034 | VANDF |
| 4019152 | VANDF |
| 4019728 | VANDF |
| CHEBI:4646 | CHEBI |
| CHEBI:28918 | CHEBI |
| CHEMBL1201262 | ChEMBL_ID |
| CHEMBL1200833 | ChEMBL_ID |
| DB00449 | DRUGBANK_ID |
| C015173 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7166 | IUPHAR_LIGAND_ID |
| 3105 | PUBCHEM_CID |
| 2447 | MMSL |
| 3451 | MMSL |
| 4618 | MMSL |
| 4663 | MMSL |
| d00699 | MMSL |
| 001774 | NDDF |
| 001788 | NDDF |
| 004978 | NDDF |
| 37013008 | SNOMEDCT_US |
| 372830005 | SNOMEDCT_US |
| 387362001 | SNOMEDCT_US |
| 65502005 | SNOMEDCT_US |
| 73647000 | SNOMEDCT_US |
| C0058415 | UMLSCUI |
| C0014563 | UMLSCUI |
| DB00668 | DRUGBANK_ID |
| 4429 | INN_ID |
| 2142 | INN_ID |
| D004837 | MESH_DESCRIPTOR_UI |
| 5816 | PUBCHEM_CID |
| 5QTH9UHV0K | UNII |
Pharmaceutical products:
None