dexniguldipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
calcium channel blockers, nifedipine derivatives	837	120054-86-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

niguldipine hydrobromide
niguldipine fumarate
niguldipine hydrochloride
niguldipine HCl
B859-35
B 859-35
B8509-035
dexniguldipine
(+)-Niguldipine
(R)-Niguldipine

Molecular weight: 609.72
Formula: C36H39N3O6
CLOGP: 7.85
LIPINSKI: 2
HAC: 9
HDO: 1
TPSA: 111.01
ALOGS: -6.73
ROTB: 12

Drug dosage:

None

ADMET properties:

Property	Value	Reference
Vd (Volume of distribution)	8.40 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	9.30 mL/min/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	22 hours	Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D002121	Calcium Channel Blockers
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D049990	Membrane Transport Modulators

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.38	Basic
pKa2	2.37	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Voltage-gated L-type calcium channel	Ion channel	Q01668 Q13936	CAC1D_HUMAN CAC1C_HUMAN	BLOCKER				SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		Ki	7.43		WOMBAT-PK
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	10		CHEMBL
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	6.18		CHEMBL
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	6.35		CHEMBL
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN		Ki	5.72		CHEMBL
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	6.77		CHEMBL
Alpha-1B adrenergic receptor	GPCR	P35368	ADA1B_HUMAN		Ki	7.25		CHEMBL
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	6.05		CHEMBL
Voltage-dependent T-type calcium channel subunit alpha-1H	Ion channel	O95180	CAC1H_HUMAN		Ki	5.82		WOMBAT-PK
Alpha-1B adrenergic receptor	GPCR		ADA1B_RAT		Ki	6.42		CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		Ki	8.20		CHEMBL
Alpha-1D adrenergic receptor	GPCR		ADA1D_RAT		Ki	7.08		CHEMBL
D(2) dopamine receptor	GPCR		DRD2_RAT		Ki	6.53		CHEMBL
Adenosine receptor A1	GPCR		AA1R_RAT		Ki	4.38		CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_BOVIN		Ki	9.42		CHEMBL
Voltage-gated L-type calcium channel	Ion channel		CAC1C_RAT CAC1D_RAT CAC1S_RAT		Ki	7.22		CHEMBL

External reference:

ID	Source
113145-69-0	SECONDARY_CAS_RN
C0208704	UMLSCUI
CHEBI:7572	CHEBI
CHEMBL2051956	ChEMBL_ID
CHEMBL405355	ChEMBL_ID
DB14068	DRUGBANK_ID
C054074	MESH_SUPPLEMENTAL_RECORD_UI
463	IUPHAR_LIGAND_ID
6938	INN_ID
N9DG6ZTC43	UNII
6918097	PUBCHEM_CID

Pharmaceutical products:

None