dexniguldipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 837 120054-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • niguldipine hydrobromide
  • niguldipine fumarate
  • niguldipine hydrochloride
  • niguldipine HCl
  • B859-35
  • B 859-35
  • B8509-035
  • dexniguldipine
  • (+)-Niguldipine
  • (R)-Niguldipine
  • Molecular weight: 609.72
  • Formula: C36H39N3O6
  • CLOGP: 7.85
  • LIPINSKI: 2
  • HAC: 9
  • HDO: 1
  • TPSA: 111.01
  • ALOGS: -6.73
  • ROTB: 12

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 8.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 9.30 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 22 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000959 Antihypertensive Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.38 Basic
pKa2 2.37 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Multidrug resistance protein 1 Transporter Ki 7.43 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 10 CHEMBL
Alpha-2B adrenergic receptor GPCR Ki 6.18 CHEMBL
Alpha-2C adrenergic receptor GPCR Ki 6.35 CHEMBL
Adenosine receptor A3 GPCR Ki 5.72 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 6.77 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 7.25 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 6.05 CHEMBL
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 5.82 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 6.42 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 8.20 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 7.08 CHEMBL
D(2) dopamine receptor GPCR Ki 6.53 CHEMBL
Adenosine receptor A1 GPCR Ki 4.38 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 9.42 CHEMBL
Voltage-gated L-type calcium channel Ion channel Ki 7.22 CHEMBL

External reference:

IDSource
113145-69-0 SECONDARY_CAS_RN
C0208704 UMLSCUI
CHEBI:7572 CHEBI
CHEMBL2051956 ChEMBL_ID
CHEMBL405355 ChEMBL_ID
DB14068 DRUGBANK_ID
C054074 MESH_SUPPLEMENTAL_RECORD_UI
463 IUPHAR_LIGAND_ID
6938 INN_ID
N9DG6ZTC43 UNII
6918097 PUBCHEM_CID

Pharmaceutical products:

None