dexloxiglumide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| cholecystokinine antagonists, antiulcer, anxiolytic agents | 834 | 119817-90-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a CCK receptor antagonist; structure given in first source
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
| BA (Bioavailability) | 48 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.18 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 3.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.20 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 0.53 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.19 | acidic |
| pKa2 | 13.75 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cholecystokinin receptor type A | GPCR | IC50 | 6.89 | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| C0533979 | UMLSCUI |
| CHEBI:135747 | CHEBI |
| CHEMBL550781 | ChEMBL_ID |
| DB04856 | DRUGBANK_ID |
| C103490 | MESH_SUPPLEMENTAL_RECORD_UI |
| 889 | IUPHAR_LIGAND_ID |
| 6782 | INN_ID |
| 69DY40RH9B | UNII |
| 65937 | PUBCHEM_CID |
Pharmaceutical products:
None