desoxycortone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 820 64-85-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • desoxycorticosterone
  • cortexone
  • deoxycorticosterone
  • deoxycortone
  • desoxycortone
A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE
  • Molecular weight: 330.47
  • Formula: C21H30O3
  • CLOGP: 3.44
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -4.30
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O
5 mg P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H02AA03 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Mineralocorticoids
MeSH PA D006728 Hormones
MeSH PA D008901 Mineralocorticoids
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.85 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Mineralocorticoid receptor Nuclear hormone receptor AGONIST IC50 11 IUPHAR CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 7.50 PDSP
5-hydroxytryptamine receptor 2C GPCR Ki 8.70 PDSP
5-hydroxytryptamine receptor 2A GPCR Ki 8.85 PDSP
Corticosteroid-binding globulin Secreted Ki 7.65 CHEMBL
Sex hormone-binding globulin Secreted Kd 7.38 CHEMBL
Glucocorticoid receptor Nuclear hormone receptor AGONIST IC50 7.20 IUPHAR

External reference:

IDSource
4019710 VUID
N0000147802 NUI
D07792 KEGG_DRUG
3256 RXNORM
4019710 VANDF
C0011710 UMLSCUI
CHEBI:16973 CHEBI
1CA PDB_CHEM_ID
CHEMBL1200542 ChEMBL_ID
CHEMBL1498 ChEMBL_ID
DB15972 DRUGBANK_ID
2871 IUPHAR_LIGAND_ID
387 INN_ID
40GP35YQ49 UNII
6166 PUBCHEM_CID
002207 NDDF
1336006 SNOMEDCT_US
56156001 SNOMEDCT_US
75029008 SNOMEDCT_US
D003900 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None