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aldosterone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| corticosteroids, except prednisolone derivatives | 111 | 52-39-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 0.947 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 21.232 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 7.211 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 3.715 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 56.690 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 62.560 | % | High | 1 |
| herg | hERG pIC50 | 4.129 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 1.774 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 8.453 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 45.690 | % | High | 1 |
| kinase-safety-class | ACVR2B,CDK5,EIF2AK3,GRK2,ITK,PDK1,PDK2,PDK4,PRKDC | 9 | |||
| kinase-selectivity-class | EIF2AK3,GRK2,MAP2K6 | 3 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 6.457 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 20.417 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 55.110 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 10.471 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 55.900 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 12.531 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 88.260 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 30.190 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 928.966 | uM | High | 1 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | H02AA01 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CORTICOSTEROIDS FOR SYSTEMIC USE CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN Mineralocorticoids |
| CHEBI has role | CHEBI:75771 | mouse metabolite |
| CHEBI has role | CHEBI:77746 | human metabolite |
Related Drugs by ATC class:
H02AA Mineralocorticoids 2 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.58 | acidic |
| pKa2 | 13.29 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Mineralocorticoid receptor | Nuclear hormone receptor | EC50 | 8.42 | CHEMBL | |||||
| Corticosteroid-binding globulin | Secreted | Ki | 6.28 | CHEMBL | |||||
| Sex hormone-binding globulin | Secreted | Kd | 5.32 | CHEMBL | |||||
| 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Kinase | EC50 | 8.89 | CHEMBL | |||||
| Mineralocorticoid receptor | Transcription factor | IC50 | 7.37 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167497 | NUI |
| D10528 | KEGG_DRUG |
| 1312358 | RXNORM |
| C0002006 | UMLSCUI |
| CHEBI:27584 | CHEBI |
| AS4 | PDB_CHEM_ID |
| CHEMBL273453 | ChEMBL_ID |
| DB04630 | DRUGBANK_ID |
| D000450 | MESH_DESCRIPTOR_UI |
| 5839 | PUBCHEM_CID |
| 2872 | IUPHAR_LIGAND_ID |
| 483 | INN_ID |
| 4964P6T9RB | UNII |
| 002206 | NDDF |
| 22474002 | SNOMEDCT_US |
| 42605004 | SNOMEDCT_US |
| 4964P6T9RB | INXIGHT DRUGS |
Pharmaceutical products:
None